1st-pass analysis of Novartis DECAMP2 Bronchial Brushings RNA-seq data

Preprocessing

Based off of prior QC (“20201025_DECAMP2_Novartis_QC_Bronch.Rmd”), we have identified several poor quality samples. We will remove these samples prior to any downstream analysis.

# Load library:
library(plyr)
library(SummarizedExperiment)
library(readxl)
library(dplyr)
library(ggplot2)
library(pheatmap)
library("RColorBrewer")
library(DESeq2)
library(knitr)
library(kableExtra)
library(enrichR)
library(biomaRt)
library(affy)
library(limma)

set.seed("12345")

# Load data:
se <- readRDS("/restricted/projectnb/pulmseq/Novartis/processing/work/28/da9dcb4ebb5f902c53fff1bc1ebdc2/Novartis_Gene_Expression.rds")
colnames(se) <- gsub(pattern = "_.*", "", colnames(se))

# Load annotation:

# Matches sample ID to kitnumber + Has batch info
annotManifest <- read_excel("/restricted/projectnb/pulmseq/Novartis/annotation/Novartis_RNASeq_run_manifest.xlsx")

# Matches sample ID to sample type/RIN (received from Jack, 8/24/20)
annotSampleEM0 <- read_excel("/restricted/projectnb/camplab/home/ykoga07/DECAMP/Novartis/Data/Annotation/RNA_data_for_Yusuke_08_24_20.xlsx", sheet = "EM0", skip = 2)

annotSampleEM5 <- read_excel("/restricted/projectnb/camplab/home/ykoga07/DECAMP/Novartis/Data/Annotation/RNA_data_for_Yusuke_08_24_20.xlsx", sheet = "EM5", skip = 2)

annotSampleEM6 <- read_excel("/restricted/projectnb/camplab/home/ykoga07/DECAMP/Novartis/Data/Annotation/RNA_data_for_Yusuke_08_24_20.xlsx", sheet = "EM6", skip = 2)

annotSampleEM8 <- read_excel("/restricted/projectnb/camplab/home/ykoga07/DECAMP/Novartis/Data/Annotation/RNA_data_for_Yusuke_08_24_20.xlsx", sheet = "EM8", skip = 3)

annotSampleEM15 <- read_excel("/restricted/projectnb/camplab/home/ykoga07/DECAMP/Novartis/Data/Annotation/RNA_data_for_Yusuke_08_24_20.xlsx", sheet = "EM15", skip = 3)

annotSampleEM16 <- read_excel("/restricted/projectnb/camplab/home/ykoga07/DECAMP/Novartis/Data/Annotation/RNA_data_for_Yusuke_08_24_20.xlsx", sheet = "EM16", skip = 3)

annotSampleN1 <- read_excel("/restricted/projectnb/camplab/home/ykoga07/DECAMP/Novartis/Data/Annotation/RNA_data_for_Yusuke_08_24_20.xlsx", sheet = "N1", skip = 3)

annotSampleN2 <- read_excel("/restricted/projectnb/camplab/home/ykoga07/DECAMP/Novartis/Data/Annotation/RNA_data_for_Yusuke_08_24_20.xlsx", sheet = "N2", skip = 3)

# Combine Jack's sample-based annotation file into one dataframe
annotSampleEM0 <- annotSampleEM0[, c(
  "RNA Sample ID", "DECAMP #",
  "Sample ID", "Kit Number", "Original Sample Type",
  "Isolation Date", "RIN", "DV200 (%)"
)]
colnames(annotSampleEM0) <- c(
  "RNA Sample ID", "DECAMP #",
  "Sample ID", "Kit Number", "Sample Type",
  "Isolation Date", "RIN", "DV200 (%)"
)

annotSampleEM5 <- annotSampleEM5[, c(
  "RNA Sample ID", "DECAMP #",
  "Patient ID", "Patient ID", "Sample Type",
  "Isolation Date", "RIN", "DV200 (%)"
)]
colnames(annotSampleEM5) <- c(
  "RNA Sample ID", "DECAMP #",
  "Sample ID", "Kit Number", "Sample Type",
  "Isolation Date", "RIN", "DV200 (%)"
)

annotSampleEM6 <- annotSampleEM6[, c(
  "RNA Sample ID", "DECAMP #",
  "Sample ID", "Kit Number", "Sample Type",
  "Isolation Date", "RIN", "DV200 (%)"
)]
colnames(annotSampleEM6) <- c(
  "RNA Sample ID", "DECAMP #",
  "Sample ID", "Kit Number", "Sample Type",
  "Isolation Date", "RIN", "DV200 (%)"
)

annotSampleEM8 <- annotSampleEM8[, c(
  "RNA Sample ID", "DECAMP #",
  "Sample ID", "Original Sample ID", "Sample Type",
  "Isolation Date", "RIN", "DV200 (%)"
)]
colnames(annotSampleEM8) <- c(
  "RNA Sample ID", "DECAMP #",
  "Sample ID", "Kit Number", "Sample Type",
  "Isolation Date", "RIN", "DV200 (%)"
)

annotSampleEM15 <- annotSampleEM15[, c(
  "RNA Sample ID", "DECAMP #",
  "Sample ID", "Kit Number", "Sample Type",
  "Isolation Date", "RIN", "DV200 (%)"
)]
colnames(annotSampleEM15) <- c(
  "RNA Sample ID", "DECAMP #",
  "Sample ID", "Kit Number", "Sample Type",
  "Isolation Date", "RIN", "DV200 (%)"
)

annotSampleEM16 <- annotSampleEM16[, c(
  "RNA Sample ID", "DECAMP #",
  "Sample ID", "Kit Number", "Sample Type",
  "Isolation Date", "RIN", "DV200 (%)"
)]
colnames(annotSampleEM16) <- c(
  "RNA Sample ID", "DECAMP #",
  "Sample ID", "Kit Number", "Sample Type",
  "Isolation Date", "RIN", "DV200 (%)"
)

annotSampleN1 <- annotSampleN1[, c(
  "RNA Sample ID", "DECAMP #",
  "Sample ID", "Kit Number", "Sample Type",
  "Isolation Date", "RIN", "DV200 (%)"
)]
colnames(annotSampleN1) <- c(
  "RNA Sample ID", "DECAMP #",
  "Sample ID", "Kit Number", "Sample Type",
  "Isolation Date", "RIN", "DV200 (%)"
)

annotSampleN2 <- annotSampleN2[, c(
  "RNA Sample ID", "DECAMP #",
  "Sample ID", "Kit Number", "Sample Type",
  "Isolation Date", "RIN", "DV200 (%)"
)]
colnames(annotSampleN2) <- c(
  "RNA Sample ID", "DECAMP #",
  "Sample ID", "Kit Number", "Sample Type",
  "Isolation Date", "RIN", "DV200 (%)"
)

allAnnotSamples <- ls()[grep("annotSample", ls())]
annotSample <- as.data.frame(matrix(ncol = 8))
colnames(annotSample) <- c(
  "RNA Sample ID", "DECAMP #",
  "Sample ID", "Kit Number", "Sample Type",
  "Isolation Date", "RIN", "DV200 (%)"
)
# Combine
for (x in allAnnotSamples) {
  annotSamples <- get(x)
  annotSamples$`Isolation Date` <- as.character(annotSamples$`Isolation Date`)
  annotSample <- rbind(annotSample, annotSamples)
}
annotSample <- annotSample[-which(is.na(annotSample$`RNA Sample ID`)), ]
annotSample <- annotSample[-which(is.na(annotSample$`Sample Type`)), ]

annotSample <- annotSample[-which(duplicated(annotSample$`RNA Sample ID`)), ]

# Save which samples had wrong rRNA peak when checking RIN
wrongRRNA.ix <- grep(pattern = "rong rRNA peak", annotSample$RIN)
annotSample$wrongRNAPeak <- 0
annotSample$wrongRNAPeak[wrongRRNA.ix] <- 1

# Edit RIN section to convert into numeric vector
annotSample$RIN <- gsub(pattern = "(wrong rRNA peak)", replacement = "", annotSample$RIN, fixed = TRUE)
annotSample$RIN <- gsub(pattern = "(wrong RNA peak)", replacement = "", annotSample$RIN, fixed = TRUE)
annotSample$RIN <- gsub(pattern = "(wrong rRNA peaks)", replacement = "", annotSample$RIN, fixed = TRUE)
annotSample$RIN <- gsub(pattern = "(Wrong rRNA peak)", replacement = "", annotSample$RIN, fixed = TRUE)
annotSample$RIN <- gsub(pattern = "(Wrong rRNA peaks)", replacement = "", annotSample$RIN, fixed = TRUE)
annotSample$RIN <- gsub(pattern = "\\/NA", replacement = "", annotSample$RIN)
annotSample$RIN <- gsub(pattern = ".*\\/", replacement = "", annotSample$RIN)
annotSample$RIN <- as.numeric(annotSample$RIN)
# There is a "29", probably 2.9, will ask Jack
annotSample$RIN[annotSample$RIN == 29] <- 2.9

# Consolidate nasal/bronch terms
annotSample$`Sample Type` <- gsub(pattern = ".*Bronch.*", replacement = "Bronchial Brushings", annotSample$`Sample Type`)
annotSample$`Sample Type` <- gsub(pattern = ".*Nasal.*", replacement = "Nasal Brushings", annotSample$`Sample Type`)

annotManifest <- filter(annotManifest, Run == "Run 1")
annotSample <- annotSample[annotSample$`RNA Sample ID` %in% annotManifest$Sample, ]
annotSample <- annotSample[match(annotSample$`RNA Sample ID`, annotManifest$Sample), ]

# Removing duplicate column
annotManifest$`Kit Number` <- NULL

annot <- cbind(annotManifest, annotSample)

# Clinical info:

# Matches kitnumber to randID, "Novartis_datadump"
annotDataDump2 <- read_excel("/restricted/projectnb/decamp/annotation/20200920/FullDECAMP2_DataDump_20200920.xlsx", sheet = "_D2CASEMAP", )

# randID to demographics info, "Novartis_datadump"
annotDataDump3 <- read_excel("/restricted/projectnb/decamp/annotation/20200920/FullDECAMP2_DataDump_20200920.xlsx", sheet = "_D2DEMO")

# randID to age/smoking info, "Novartis_datadump"
annotDataDump4 <- read_excel("/restricted/projectnb/decamp/annotation/20200920/FullDECAMP2_DataDump_20200920.xlsx", sheet = "_D2ELIGCHECK")

# randID to FEV/FVC, "Novartis_datadump"
annotDataDump5 <- read_excel("/restricted/projectnb/decamp/annotation/20200920/FullDECAMP2_DataDump_20200920.xlsx", sheet = "_D2PFT")
annotDataDump5 <- filter(annotDataDump5, timepoint == "Baseline Visit")

# Combine annotation info
annotA <- merge(merge(annotDataDump2, annotDataDump3, by.x = "randID", by.y = "randID"), annotDataDump4, by.x = "randID", by.y = "randID")
annotA <- merge(annotA, annotDataDump5, by.x = "randID", by.y = "randID")

# Removing patient "4796-053" as "Pacific Islander" for time being
annotA <- annotA[!(duplicated(annotA$randID)), ]

annot <- merge(annot, annotA, by.x = "Kit Number", by.y = "kitnumber", all.x = TRUE)

annotBronch <- annot[annot$`Sample Type` == "Bronchial Brushings", ]
annotNasal <- annot[annot$`Sample Type` == "Nasal Brushings", ]

uniquePatients <- length(unique(annot$`Kit Number`))

numBronch <- length(unique(annotBronch$Sample))
numNasal <- length(unique(annotNasal$Sample))

bothBronchNasal <- length(intersect(annotBronch$`Kit Number`, annotNasal$`Kit Number`))

#Steiling signature genes
steilingGenes <- read_excel("/restricted/projectnb/camplab/home/ykoga07/DECAMP/Novartis/Analysis/1stPass/Steiling_2013_Genelist.xlsx", sheet = "GeneList", col_names = FALSE)

There are 280 samples and 201 unique patients in the dataset. 80 are nasal samples. There are 79 patients that have both bronchial and nasal samples.

# Samples flagged by Novartis as poor quality:
# flaggedByNovartis <- c(
#   "EM15-14", "EM15-31", "EM15-64", "EM15-85", "EM16-194", "EM16-195",
#   "EM16-228", "EM5-100", "EM8-112", "EM8-130", "EM8-158", "EM8-171",
#   "EM8-26", "EM8-55", "EM8-66", "N1-115", "N1-119", "N1-125",
#   "N1-139", "N1-25", "N1-40", "N1-55", "N1-63", "N1-64",
#   "N1-67", "N1-81", "N1-83", "N1-84", "N1-94", "N2-10",
#   "N2-15", "N2-18", "N2-30", "N2-31", "N2-22", "N2-28"
# )

poorQuality <- read.table("/restricted/projectnb/camplab/home/ykoga07/DECAMP/Novartis/Analysis/QC/20201026_PoorQuality_Bronch.txt")

seBronch <- se[, which(colnames(se) %in% annotBronch$`RNA Sample ID`)]
orig.num.samples <- ncol(seBronch) 

#Remove:
seBronch <- seBronch[,!colnames(seBronch) %in% poorQuality$x]
filt.num.samples <- ncol(seBronch) 

annotBronch <- annotBronch[annotBronch$`RNA Sample ID` %in% colnames(se), ]

# reorder
annotBronch <- annotBronch[match(colnames(seBronch), annotBronch$`RNA Sample ID`), ]

coldataBronch <- colData(seBronch)
annotBronch$TIN <- colData(seBronch)$RSeQC_TIN_mean

Originally, there were 200 samples. Upon filtering, we will use 173 samples for downstream analysis.

counts <- assay(seBronch)
rownames(counts) <- rowRanges(seBronch)$external_gene_id

counts <- apply(counts, 1:2, function(x) {
  return(as.integer(x))
})

# arglist <- list(x=annotBronch$FEV_RS_PER,y=annotBronch$FEV_FVC)
# statusfxn <- function(x,y) {
#   if (x < 80 && y < 0.7) {
#     return("COPD")
#   } else {
#     return("NO_COPD")
#   }
# }
# copd.status <- sapply(arglist, statusfxn, x = x, y = y)

copd.status <- c()
for(x in 1:nrow(annotBronch)){
  if(annotBronch[x, "FEV_RS_PER"] < 80 && 
     annotBronch[x, "FEV_FVC"] < 0.7){
        copd.status <- c(copd.status, "COPD")
  }else{
       copd.status <- c(copd.status, "NO_COPD")
     }
}

annotBronch$COPD_status <- as.factor(copd.status)

annotBronch$GRPB_SMK_STS <- gsub(" ", "_", annotBronch$GRPB_SMK_STS)

no.smk.status.ix <- which(is.na(annotBronch$GRPB_SMK_STS))

counts <- counts[, -no.smk.status.ix]
annotBronch <- annotBronch[-no.smk.status.ix, ]

2 samples were removed due to lack of smoker status.

Clinical annotation

General annotation data of patients were compared between those of which samples of FEV1 predicted < 80 (COPD) and FEV1 predicted > 80 (NO COPD).

#Rename race
annotBronch$RACE_CAT_TXT <- gsub("Unknown","Not Reported",annotBronch$RACE_CAT_TXT)
annotBronch$RACE_CAT_TXT <- gsub("Black or Afr. American",
                                 "Black/African American",annotBronch$RACE_CAT_TXT)
annotBronch$RACE_CAT_TXT <- gsub("Native Hawaiian or Other Pacific Islander",
                                 "Pacific Islander",annotBronch$RACE_CAT_TXT)
annotBronch$RACE_CAT_TXT <- gsub("American Indian or Alaska Native",
                                 "Native American",annotBronch$RACE_CAT_TXT)
annotBronch$RACE_CAT_TXT <- as.factor(annotBronch$RACE_CAT_TXT)

annotBronch_COPD <- annotBronch[annotBronch$COPD_status == "COPD", ]

annotBronch_NO_COPD <- annotBronch[annotBronch$COPD_status == "NO_COPD", ]

lab <- c(
  rep("Retained", length(annotBronch_COPD$GRPB_SMK_STS)),
  rep("Removed", length(annotBronch_NO_COPD$GRPB_SMK_STS))
)
# AGE
mean.age <- mean(annotBronch_COPD$AGE)
sd.age <- sd(annotBronch_COPD$AGE)

age <- paste0(signif(mean.age, 3), " +/- ", signif(sd.age, 3))

mean.age.rm <- mean(annotBronch_NO_COPD$AGE)
sd.age.rm <- sd(annotBronch_NO_COPD$AGE)

age.rm <- paste0(signif(mean.age.rm, 3), " +/- ", signif(sd.age.rm, 3))

age.pvalue <- signif(wilcox.test(annotBronch_COPD$AGE, annotBronch_NO_COPD$AGE)$p.value, 3)

demo.table <- c(age, age.rm, age.pvalue)

# Gender
gstatus <- c(annotBronch_COPD$PERSON_GENDER, annotBronch_NO_COPD$PERSON_GENDER)

male.ct <- sum(annotBronch_COPD$PERSON_GENDER == "Male Gender")
male.pct <- signif(male.ct / length(annotBronch_COPD$PERSON_GENDER), 3) * 100
male <- paste0("Male: ", male.ct, "(", male.pct, "%)")

male.ct.rm <- sum(annotBronch_NO_COPD$PERSON_GENDER == "Male Gender")
male.pct.rm <- signif(male.ct.rm / length(annotBronch_NO_COPD$PERSON_GENDER), 3) * 100
male.rm <- paste0("Male: ", male.ct.rm, "(", male.pct.rm, "%)")

gender.pvalue <- signif(chisq.test(table(lab, gstatus))$p.value, 3)

demo.table <- rbind(demo.table, c(male, male.rm, gender.pvalue))

# FEV1 predicted
mean.fev1p <- mean(annotBronch_COPD$FEV_RS_PER)
sd.fev1p <- sd(annotBronch_COPD$FEV_RS_PER)

fev1p <- paste0(signif(mean.fev1p, 3), " +/- ", signif(sd.fev1p, 3))

mean.fev1p.rm <- mean(annotBronch_NO_COPD$FEV_RS_PER)
sd.fev1p.rm <- sd(annotBronch_NO_COPD$FEV_RS_PER)

fev1p.rm <- paste0(signif(mean.fev1p.rm, 3), " +/- ", signif(sd.fev1p.rm, 3))

fev1p.pvalue <- signif(wilcox.test(annotBronch_COPD$FEV_RS_PER, annotBronch_NO_COPD$FEV_RS_PER)$p.value, 3)

demo.table <- rbind(demo.table, c(fev1p, fev1p.rm, fev1p.pvalue))

# FEVFVC
mean.fevfvc <- mean(annotBronch_COPD$FEV_FVC)
sd.fevfvc <- sd(annotBronch_COPD$FEV_FVC)

fevfvc <- paste0(signif(mean.fevfvc, 3), " +/- ", signif(sd.fevfvc, 3))

mean.fevfvc.rm <- mean(annotBronch_NO_COPD$FEV_FVC)
sd.fevfvc.rm <- sd(annotBronch_NO_COPD$FEV_FVC)

fevfvc.rm <- paste0(signif(mean.fevfvc.rm, 3), " +/- ", signif(sd.fevfvc.rm, 3))

fevfvc.pvalue <- signif(wilcox.test(annotBronch_COPD$FEV_FVC, annotBronch_NO_COPD$FEV_FVC)$p.value, 3)

demo.table <- rbind(demo.table, c(fevfvc, fevfvc.rm, fevfvc.pvalue))

# TIN
mean.tin <- mean(annotBronch_COPD$TIN)
sd.tin <- sd(annotBronch_COPD$TIN)

tin <- paste0(signif(mean.tin, 3), " +/- ", signif(sd.tin, 3))

mean.tin.rm <- mean(annotBronch_NO_COPD$TIN)
sd.tin.rm <- sd(annotBronch_NO_COPD$TIN)

tin.rm <- paste0(signif(mean.tin.rm, 3), " +/- ", signif(sd.tin.rm, 3))

tin.pvalue <- signif(wilcox.test(annotBronch_COPD$TIN, annotBronch_NO_COPD$TIN)$p.value, 3)

demo.table <- rbind(demo.table, c(tin, tin.rm, tin.pvalue))

# Smoking Status
smk <- c(annotBronch_COPD$GRPB_SMK_STS, annotBronch_NO_COPD$GRPB_SMK_STS)

annotBronch_COPD$GRPB_SMK_STS <- gsub(" ", "_", annotBronch_COPD$GRPB_SMK_STS)
annotBronch_NO_COPD$GRPB_SMK_STS <- gsub(" ", "_", annotBronch_NO_COPD$GRPB_SMK_STS)

smkstatus.na <- sum(is.na(annotBronch_COPD$GRPB_SMK_STS == "Current_Smoker"))

smkstatus.ct <- sum(annotBronch_COPD[!is.na(annotBronch_COPD$GRPB_SMK_STS), ]$GRPB_SMK_STS == "Current_Smoker")
smkstatus.pct <- signif(smkstatus.ct / nrow(annotBronch_COPD[!is.na(annotBronch_COPD$GRPB_SMK_STS), ]), 3) * 100
smkstatus <- paste0("Current: ", smkstatus.ct, "(", smkstatus.pct, "%)")

smkstatus.ct.rm <- sum(annotBronch_NO_COPD$GRPB_SMK_STS == "Current_Smoker")
smkstatus.pct.rm <- signif(smkstatus.ct.rm / length(annotBronch_NO_COPD$GRPB_SMK_STS), 3) * 100
smkstatus.rm <- paste0("Current: ", smkstatus.ct.rm, "(", smkstatus.pct.rm, "%)")

smkstatus.pvalue <- signif(chisq.test(table(lab, smk))$p.value, 3)

demo.table <- rbind(demo.table, c(smkstatus, smkstatus.rm, smkstatus.pvalue))

rownames(demo.table) <- c("Age", "Gender", "FEV1 Predicted(%)" , "FEV1/FVC", "TIN", "Smoking Status")
colnames(demo.table) <- c("COPD", "NO COPD", "p-value")

copd.race.table <- as.data.frame(table(annotBronch_COPD$RACE_CAT_TXT))
rownames(copd.race.table) <- copd.race.table$Var1
copd.race.table$Var1 <- NULL

nocopd.race.table <- as.data.frame(table(annotBronch_NO_COPD$RACE_CAT_TXT))
rownames(nocopd.race.table) <- nocopd.race.table$Var1
nocopd.race.table$Var1 <- NULL

race.table <- cbind(copd.race.table, nocopd.race.table)
race.table <- race.table[c(6, 2, 1, 5, 3, 4),]
colnames(race.table) <- c("COPD", "NO COPD")
race.table$`p-value` <- c(signif(chisq.test(race.table)$p.value, 3),
                        rep("", nrow(race.table) - 1))

blank <- as.data.frame(matrix("", ncol = 3))
colnames(blank) <- c("COPD", "NO COPD", "p-value")
rownames(blank) <- "Race"

race.table <- rbind(blank,race.table)

demo.table <- rbind(demo.table, race.table)

demo.table %>%
  knitr::kable(
    format = "html", align = rep("c", ncol(demo.table) + 1),
    row.names = TRUE
  ) %>%
  add_indent(c(8:13)) %>%
  kableExtra::kable_styling()

	COPD	NO COPD	p-value
Age	63.4 +/- 5.72	63.3 +/- 6.6	0.804
Gender	Male: 71(78%)	Male: 67(83.8%)	0.452
FEV1 Predicted(%)	60.5 +/- 12.4	86.5 +/- 13.5	1.37e-22
FEV1/FVC	0.563 +/- 0.1	0.717 +/- 0.067	2.04e-21
TIN	70.5 +/- 1.23	70.4 +/- 1.44	0.903
Smoking Status	Current: 34(37.4%)	Current: 28(35%)	0.872
Race
White	69	61	0.518
Black or African American	17	11
Asian	2	2
Pacific Islander	2	1
Native American	0	1
Not Reported	1	4

Differential Expression

Using COPD as continuous variable

Differential expression was conducted using the DESeq2 package to compare patients with low FEV1pred values (< 80) and high values. The FEV1 predicted values are used as a proxy for COPD status. Expected counts outputted from the RSEM algorithm was taken for DESeq2.

Model used: ~Smoking status + Age + TIN + FEV1 predicted

dds <- DESeqDataSetFromMatrix(
  countData = counts,
  colData = annotBronch,
  design = ~GRPB_SMK_STS + AGE + TIN + FEV_RS_PER
)

dds$GRPB_SMK_STS <- relevel(dds$GRPB_SMK_STS, ref = "Former_Smoker")

keep <- rowSums(counts(dds)) >= 10
dds <- dds[keep, ]
dds <- DESeq(dds)
res <- results(dds)

res$nLogPVal <- -log10(res$padj)

resOrdered <- res[order(res$pvalue), ]
resOrdered <- as.data.frame(resOrdered)

#For pre-ranked GSEA
resOrderLFC <- res[order(res$log2FoldChange), ]
resOrderLFC <- resOrderLFC[,2, drop = F]
resOrderLFC$Gene <- rownames(resOrderLFC)
resOrderLFC <- resOrderLFC[,c(2,1)]
#write.table(resOrderLFC, "20201104_GSEA_Rankedlist_FEVPred_Bronch.rnk", sep = "\t", col.names = T, row.names = F)

resSig <- resOrdered[resOrdered$padj < 0.05,]
resSig <- resSig[!is.na(resSig$padj),]

resSig <- resSig[order(resSig$log2FoldChange), ]
numSig <- nrow(resSig)

resSigUp <- resSig[head(order(resSig$log2FoldChange, decreasing = T), 50),]
resSigDown <- resSig[head(order(resSig$log2FoldChange, decreasing = F), 50),]
resSig2 <- rbind(resSigDown, resSigUp)
# numUp <- nrow(resSig[resSig$log2FoldChange > 0.5, ])
# numDown <- nrow(resSig[resSig$log2FoldChange < -0.5, ])

resSig3 <- resSig[abs(resSig$log2FoldChange) > 0.01,]

A total of 1234 genes were passed the adjusted p-value < 0.05 threshold.

Volcano plot

g <- ggplot(resOrdered, aes(x = log2FoldChange, y = nLogPVal)) +
  geom_point(size = 0.75) +
  ggplot2::theme_bw() +
  ggplot2::theme(
    panel.grid.major = ggplot2::element_blank(),
    panel.grid.minor = ggplot2::element_blank(),
    axis.text = ggplot2::element_text(size = 14),
    axis.title = ggplot2::element_text(size = 14)
  ) +
  ggplot2::theme(legend.title = ggplot2::element_text(size = 15), legend.text = ggplot2::element_text(size = 13)) +
  ggplot2::guides(
    colour =
      ggplot2::guide_legend(override.aes = list(size = 2))
  )
if(nrow(resSig2) > 0){
g <- g +
  geom_point(data = resSig2, aes(x = log2FoldChange, y = nLogPVal), color = "Red")+
  ggplot2::labs(y = "-log10(Adjusted p-value)") +
  ggplot2::ggtitle(label = "COPD status") +
  ggplot2::theme(plot.title = ggplot2::element_text(
    hjust = 0.5,
    size = 18
  )) + geom_line(y = 1.3)
}

g

The red dots show the top 50 most up/down regulated genes which pass the adjusted p-value threshold.

Heatmap

All genes, FDR < 0.05

counts.z <- t(scale(t(counts)))
counts.z.trim <- counts.z

counts.z.trim[counts.z.trim < -2] <- -2
counts.z.trim[counts.z.trim > 2] <- 2

counts.z.trim <- counts.z.trim[rownames(counts.z.trim) %in% rownames(resSig),]

COPD_status <- annotBronch$COPD_status
Smoker_status <- annotBronch$GRPB_SMK_STS

annotation_col <- data.frame(COPD_status, Smoker_status)
rownames(annotation_col) <- colnames(counts.z.trim)
callback <- function(hc, mat) {
  sv <- svd(t(mat))$v[, 1]
  dend <- reorder(as.dendrogram(hc), wts = sv)
  as.hclust(dend)
}

out <- pheatmap(counts.z.trim,
  color = colorRampPalette(rev(brewer.pal(n = 7, name = "RdYlBu")))(100),
  annotation_col = annotation_col,
  legend = T,
  show_rownames = F,
  show_colnames = F,
  fontsize_row = 9,
  cluster_rows = TRUE,
  cluster_cols = TRUE
)

out

FDR < 0.05, Log2 Fold change > 0.01

474 genes total:

counts.z <- t(scale(t(counts)))
counts.z.trim <- counts.z

counts.z.trim[counts.z.trim < -2] <- -2
counts.z.trim[counts.z.trim > 2] <- 2

counts.z.trim <- counts.z.trim[rownames(counts.z.trim) %in% rownames(resSig3),]

COPD_status <- annotBronch$COPD_status
Smoker_status <- annotBronch$GRPB_SMK_STS

annotation_col <- data.frame(COPD_status, Smoker_status)
rownames(annotation_col) <- colnames(counts.z.trim)
callback <- function(hc, mat) {
  sv <- svd(t(mat))$v[, 1]
  dend <- reorder(as.dendrogram(hc), wts = sv)
  as.hclust(dend)
}

out <- pheatmap(counts.z.trim,
  color = colorRampPalette(rev(brewer.pal(n = 7, name = "RdYlBu")))(100),
  annotation_col = annotation_col,
  legend = T,
  show_rownames = F,
  show_colnames = F,
  fontsize_row = 9,
  cluster_rows = TRUE,
  cluster_cols = TRUE
)

out

Top 50 up/downreg genes, FDR < 0.05

counts.z <- t(scale(t(counts)))
counts.z.trim <- counts.z

counts.z.trim[counts.z.trim < -2] <- -2
counts.z.trim[counts.z.trim > 2] <- 2

counts.z.trim <- counts.z.trim[rownames(counts.z.trim) %in% rownames(resSig2),]

COPD_status <- annotBronch$COPD_status
Smoker_status <- annotBronch$GRPB_SMK_STS

annotation_col <- data.frame(COPD_status, Smoker_status)
rownames(annotation_col) <- colnames(counts.z.trim)
callback <- function(hc, mat) {
  sv <- svd(t(mat))$v[, 1]
  dend <- reorder(as.dendrogram(hc), wts = sv)
  as.hclust(dend)
}

out <- pheatmap(counts.z.trim,
  color = colorRampPalette(rev(brewer.pal(n = 7, name = "RdYlBu")))(100),
  annotation_col = annotation_col,
  legend = T,
  show_rownames = F,
  show_colnames = F,
  fontsize_row = 9,
  cluster_rows = TRUE,
  cluster_cols = TRUE
)

out

Tables

Top 50 most upregulated in higher FEV1 predicted, passing adjusted p-val threshold

resSigUp <- resSig[head(order(resSig$log2FoldChange, decreasing = T), 50),]
resSigUp <- resSigUp[,c(2,5,6)]
colnames(resSigUp) <- c("Log2FC", "P-value", "Adj. P-value")
resSigUp %>%
  knitr::kable(
    format = "html", align = rep("c", ncol(resSig) + 1),
    row.names = TRUE
  ) %>%
  kableExtra::kable_styling() %>%
  kableExtra::scroll_box(height = "300px")

	Log2FC	P-value	Adj. P-value
PRSS27	0.0379322	0.0000002	0.0002730
COL4A3	0.0365198	0.0000034	0.0016830
WSCD2	0.0289860	0.0005595	0.0230708
HOPX	0.0273427	0.0000001	0.0001944
ANXA9	0.0269131	0.0000076	0.0023858
TRBV20-1	0.0267765	0.0002577	0.0153139
GPM6A	0.0267225	0.0001038	0.0095784
KRT4	0.0253379	0.0000648	0.0074744
LGI3	0.0250411	0.0001393	0.0109865
SFTPD	0.0249287	0.0000008	0.0007153
VGLL1	0.0249255	0.0005055	0.0218765
SOGA3	0.0242900	0.0005414	0.0228082
LRCH2	0.0241826	0.0002670	0.0156622
LYPD2	0.0241066	0.0002184	0.0140391
RP11-493K19.3	0.0237056	0.0000286	0.0049170
CYP4F22	0.0234669	0.0017149	0.0410806
WNK4	0.0233429	0.0009922	0.0312846
GCOM1	0.0229288	0.0000214	0.0040991
KCNAB1	0.0226309	0.0018498	0.0423868
CCR6	0.0223424	0.0014622	0.0378144
COL11A2	0.0215869	0.0004802	0.0211319
SCUBE1	0.0214229	0.0000167	0.0035708
GPR25	0.0211229	0.0011971	0.0341430
RP1-214M20.2	0.0211051	0.0002003	0.0134020
GRIK1	0.0208795	0.0001860	0.0128619
KLRC3	0.0206905	0.0004250	0.0199691
CNFN	0.0206484	0.0002364	0.0146705
FRMPD4	0.0205462	0.0004602	0.0206864
MC4R	0.0202437	0.0017792	0.0417944
GABBR2	0.0201894	0.0001731	0.0121874
TGM3	0.0198160	0.0000482	0.0062098
TTN	0.0195382	0.0001459	0.0112596
ABCG2	0.0193495	0.0004597	0.0206864
TRGV9	0.0192770	0.0008214	0.0278741
LINC01140	0.0189824	0.0000563	0.0069139
RP1-302D9.3	0.0188891	0.0011866	0.0340451
NDRG4	0.0186677	0.0000000	0.0000894
DMRT1	0.0184242	0.0014015	0.0372039
CLCA4	0.0182427	0.0006618	0.0250146
PNMAL1	0.0182427	0.0000489	0.0062591
IL23R	0.0182318	0.0010009	0.0313901
ISLR	0.0179292	0.0000413	0.0057640
TRGC1	0.0177230	0.0002066	0.0136422
LYPD1	0.0176844	0.0001246	0.0103622
HTR2B	0.0176811	0.0001100	0.0097128
RP4-635E18.6	0.0176241	0.0001005	0.0095321
CTSW	0.0176167	0.0012864	0.0356947
JAM2	0.0174415	0.0026048	0.0499456
SVOP	0.0170479	0.0023990	0.0474275
EEF1A1P13	0.0169299	0.0000057	0.0019819

Top 50 most downregulated in higher FEV1 predicted, passing adjusted p-val threshold

resSigDown <- resSig[head(order(resSig$log2FoldChange, decreasing = F), 50),]
resSigDown <- resSigDown[,c(2,5,6)]
colnames(resSigDown) <- c("Log2FC", "P-value", "Adj. P-value")
resSigDown %>%
  knitr::kable(
    format = "html", align = rep("c", ncol(resSig) + 1),
    row.names = TRUE
  ) %>%
  kableExtra::kable_styling() %>%
  kableExtra::scroll_box(height = "300px")

	Log2FC	P-value	Adj. P-value
BPIFB6	-0.0484129	0.0000008	0.0007153
Z82214.3	-0.0475271	0.0000042	0.0017656
APOB	-0.0452260	0.0000000	0.0000520
MUC6	-0.0375644	0.0000454	0.0060877
SLC13A5	-0.0362348	0.0000002	0.0003003
BPIFB2	-0.0360447	0.0000040	0.0017584
GAPDHP24	-0.0357892	0.0000656	0.0074744
TPO	-0.0346712	0.0000002	0.0002730
CDH15	-0.0340649	0.0000050	0.0019048
ARHGAP40	-0.0339831	0.0000001	0.0002175
ADAMTS2	-0.0331682	0.0002798	0.0160567
REG4	-0.0330795	0.0001281	0.0104900
CACNA1E	-0.0317633	0.0000000	0.0000148
CREG2	-0.0313896	0.0005600	0.0230708
U3.80	-0.0312975	0.0001503	0.0113298
PIRT	-0.0310768	0.0014278	0.0373721
RP11-481N16.1	-0.0307317	0.0005510	0.0229493
CYP17A1	-0.0307271	0.0002142	0.0138803
AKR1B15	-0.0307221	0.0018493	0.0423868
PTHLH	-0.0304859	0.0000000	0.0000894
RP11-157E16.1	-0.0304788	0.0002690	0.0157058
RP11-16E12.2	-0.0300302	0.0000032	0.0016404
SEMA6B	-0.0297027	0.0000248	0.0046511
IL19	-0.0293362	0.0000041	0.0017584
CHRM1	-0.0291805	0.0003002	0.0164826
ZDHHC4P1	-0.0289177	0.0000001	0.0001944
CCL2	-0.0284188	0.0016311	0.0402878
RP11-167N4.2	-0.0282905	0.0000959	0.0093885
SLC25A48	-0.0276517	0.0001416	0.0110567
ALOX15B	-0.0271650	0.0006381	0.0246279
ANO7	-0.0265786	0.0000001	0.0002251
IL17REL	-0.0265489	0.0000328	0.0050852
CUX2	-0.0260713	0.0000006	0.0006226
AL133373.1	-0.0259011	0.0000002	0.0003003
FBN2	-0.0256705	0.0000000	0.0000145
RP11-395B7.2	-0.0256592	0.0000197	0.0039108
CTD-2530H12.7	-0.0248494	0.0000021	0.0014090
STXBP5L	-0.0245286	0.0008426	0.0282699
NTRK2	-0.0244881	0.0000192	0.0038664
LINC00632	-0.0235877	0.0000469	0.0061483
DUSP5P1	-0.0235702	0.0000309	0.0049938
SNTG2	-0.0235254	0.0000199	0.0039108
CCL24	-0.0235165	0.0016407	0.0403513
RP11-115D19.1	-0.0234537	0.0009154	0.0299849
ZNF467	-0.0233902	0.0000002	0.0003003
AZGP1	-0.0233431	0.0000005	0.0005460
RPS20P1	-0.0232315	0.0000031	0.0016404
BCAS2P2	-0.0231343	0.0000151	0.0034200
ASB11	-0.0228571	0.0005534	0.0229795
B3GNT6	-0.0228472	0.0008057	0.0276069

Using COPD as categorical variable

Differential expression was conducted using the DESeq2 package to compare patients with low FEV1pred values (< 80) and high values, where all samples with low FEV1pred is considered to be COPD. Expected counts outputted from the RSEM algorithm was taken for DESeq2.

Model used: ~Smoking status + Age + TIN + COPD status

dds <- DESeqDataSetFromMatrix(
  countData = counts,
  colData = annotBronch,
  design = ~GRPB_SMK_STS + AGE + TIN + COPD_status
)

dds$GRPB_SMK_STS <- relevel(dds$GRPB_SMK_STS, ref = "Former_Smoker")
dds$COPD_status <- relevel(dds$COPD_status, ref = "NO_COPD")

keep <- rowSums(counts(dds)) >= 10
dds <- dds[keep, ]
dds <- DESeq(dds)
res <- results(dds)

res$nLogPVal <- -log10(res$padj)

resOrdered <- res[order(res$pvalue), ]
resOrdered <- as.data.frame(resOrdered)

#For pre-ranked GSEA
resOrderLFC <- res[order(res$log2FoldChange, decreasing = FALSE), ]
resOrderLFC <- resOrderLFC[,2, drop = F]
resOrderLFC$SAMPLE <- rownames(resOrderLFC)
resOrderLFC <- resOrderLFC[,c(2,1)]

write.table(resOrderLFC, "20201104_GSEA_Rankedlist_COPDstatus_Bronch.rnk", sep = "\t", col.names = T, row.names = F)

resSig <- resOrdered %>%
  filter(padj < 0.05) %>%
  filter(abs(log2FoldChange) > 0.5)
numSig <- nrow(resSig)
numUp <- nrow(resSig[resSig$log2FoldChange > 0.5, ])
numDown <- nrow(resSig[resSig$log2FoldChange < -0.5, ])

A total of 619(419 Upregulated, 200 Downregulated) genes were differentially expressed (padj < 0.05, abs(log2FC) > 0.5).

Corresponding microarray analysis

# steilingMicroarray <- readRDS("/restricted/projectnb/camplab/home/ykoga07/DECAMP/Novartis/Data/STEILING_bronch.RDS")
# 
# arrayPheno <- Biobase::pData(steilingMicroarray)
# arrayPheno$fev1_fvc_ratio <- arrayPheno$fev1_fvc_ratio/100
# 
# design <- model.matrix(~smoking_status+age+copd, data = arrayPheno)
# # design <- model.matrix(~percent_fev1+fev1_fvc_ratio+smoking_status+age+copd, data = arrayPheno)
# # design <- model.matrix(~percent_fev1+fev1_fvc_ratio+smoking_status+age+copd, data = arrayPheno)
# 
# fit <- lmFit(steilingMicroarray, design)  # fit each probeset to model
# efit <- eBayes(fit)        # empirical Bayes adjustment
# de.res <- topTable(efit, coef=2, number = 100000)
# 
# de.res$GeneName <- gsub("_at","",rownames(de.res))
# de.res$nLogPVal <- -log(de.res$adj.P.Val)
# eset.ranklist <- de.res[,c(9,3)]
# eset.ranklist <- eset.ranklist[order(eset.ranklist$logFC, decreasing = FALSE),]
# eset.ranklist <- read.table("/restricted/projectnb/camplab/home/ykoga07/DECAMP/Novartis/Analysis/1stPass/100525_lam_copdcovars_tval.rnk", header = F)
# 
# mart <- useMart(biomart = "ensembl", dataset = "hsapiens_gene_ensembl")
# 
# BM <- getBM(filters= "hgnc_symbol", attributes= c("ensembl_gene_id","hgnc_symbol"),values=eset.ranklist$V1,mart= mart)
# 
# BM <- BM[BM$ensembl_gene_id %in% rownames(assay(seBronch)),]
# BM <- BM[!duplicated(BM$hgnc_symbol),]
# mergeBM <- merge(eset.ranklist, BM, by.x = "V1", by.y = "hgnc_symbol")
# mergeBM <- mergeBM[,c(3,2)]
# mergeBM <- mergeBM[order(mergeBM$V2, decreasing = F),]
# mergeBM <- mergeBM[!duplicated(mergeBM$ensembl_gene_id),]
# 
# resSig2 <- resSig[rownames(resSig) %in% mergeBM$ensembl_gene_id,]
# resSig2Up <- resSig2[resSig2$log2FoldChange>0.5,]
# resSig2Down <- resSig2[resSig2$log2FoldChange < -0.5,]
# write.table(x = rownames(resSig2Up), file = "/restricted/projectnb/camplab/home/ykoga07/DECAMP/Novartis/Analysis/1stPass/20201125_DECAMP_Bronch_geneList_Up.grp", col.names = F, row.names = F)
# write.table(x = rownames(resSig2Down), file = "/restricted/projectnb/camplab/home/ykoga07/DECAMP/Novartis/Analysis/1stPass/20201125_DECAMP_Bronch_geneList_Down.grp", col.names = F, row.names = F)
# write.table(mergeBM, "20201125_GSEA_Rankedlist_COPDstatus_Bronch_FromSteilingMicroarray.rnk", sep = "\t", col.names = F, row.names = F)

Volcano plot

ggplot(resOrdered, aes(x = log2FoldChange, y = nLogPVal)) +
  geom_point(size = 0.75) +
  ggplot2::theme_bw() +
  ggplot2::theme(
    panel.grid.major = ggplot2::element_blank(),
    panel.grid.minor = ggplot2::element_blank(),
    axis.text = ggplot2::element_text(size = 14),
    axis.title = ggplot2::element_text(size = 14)
  ) +
  ggplot2::theme(legend.title = ggplot2::element_text(size = 15), legend.text = ggplot2::element_text(size = 13)) +
  ggplot2::guides(
    colour =
      ggplot2::guide_legend(override.aes = list(size = 2))
  ) +
  geom_point(data = resSig, aes(x = log2FoldChange, y = nLogPVal), color = "Red")+
  ggplot2::labs(y = "-log10(Adjusted p-value)") +
  ggplot2::ggtitle(label = "COPD status") +
  ggplot2::theme(plot.title = ggplot2::element_text(
    hjust = 0.5,
    size = 18
  ))

Heatmap

counts.z <- t(scale(t(counts)))
counts.z.trim <- counts.z

counts.z.trim[counts.z.trim < -2] <- -2
counts.z.trim[counts.z.trim > 2] <- 2

counts.z.trim <- counts.z.trim[rownames(counts.z.trim) %in% rownames(resSig),]

COPD_status <- annotBronch$COPD_status
Smoker_status <- annotBronch$GRPB_SMK_STS

annotation_col <- data.frame(COPD_status, Smoker_status)
rownames(annotation_col) <- colnames(counts.z.trim)
callback <- function(hc, mat) {
  sv <- svd(t(mat))$v[, 1]
  dend <- reorder(as.dendrogram(hc), wts = sv)
  as.hclust(dend)
}

out <- pheatmap(counts.z.trim,
  color = colorRampPalette(rev(brewer.pal(n = 7, name = "RdYlBu")))(100),
  annotation_col = annotation_col,
  legend = T,
  show_rownames = F,
  show_colnames = F,
  fontsize_row = 9,
  cluster_rows = TRUE,
  cluster_cols = TRUE
)

out

Violin Plots

dots <- T
boxplot <- F
violin <- T

df <- data.frame(
  x = annotBronch$`Sample Type`,
  y = counts["CEACAM5",]
)

p <- ggplot2::ggplot(df) +
  ggplot2::aes_string(
    x = "x",
    y = "y"
  )
if (dots == TRUE) {
  p <- p + ggplot2::geom_jitter(
    color = "blue",
    width = 0.2,
    height = 0,
    size = 1,
    alpha = 1
  )
}
if (boxplot == TRUE) {
  p <- p + ggplot2::geom_boxplot(
    width = 0.5,
    alpha = 0
  )
}
if (violin == TRUE) {
  p <- p + ggplot2::geom_violin(
    trim = TRUE,
    scale = "width",
    size = 1,
    fill = "grey",
    alpha = 0.75
  )
}

p <- p + ggplot2::theme_bw() +
  ggplot2::theme(
    panel.grid.major = ggplot2::element_blank(),
    panel.grid.minor = ggplot2::element_blank(),
    axis.text = ggplot2::element_text(size = 14),
    axis.title = ggplot2::element_text(size = 10)
  ) + ggplot2::theme(axis.text.x = ggplot2::element_text(size = 15)) +
  ggplot2::ylab("Counts") +
  ggplot2::theme(
    axis.title.y = element_text(size = 15),
    axis.title.x = ggplot2::element_blank()
  )

p <- p + ggplot2::ggtitle(label = "Gene: CEACAM5") +
  ggplot2::theme(plot.title = ggplot2::element_text(
    hjust = 0.5,
    size = 18
  ))

p

Tables

Differentially expressed in COPD patients

resSigDown <- resSig[resSig$log2FoldChange < -0.5, ]
resSigDown <- resSigDown[order(resSigDown$log2FoldChange, decreasing = F),]
resSigDown <- resSigDown[,c(2,5,6)]
colnames(resSigDown) <- c("Log2FC", "P-value", "Adj. P-value")
resSigDown %>%
  knitr::kable(
    format = "html", align = rep("c", ncol(resSig) + 1),
    row.names = TRUE
  ) %>%
  kableExtra::kable_styling() %>%
  kableExtra::scroll_box(height = "300px")

	Log2FC	P-value	Adj. P-value
HCG22	-2.3864692	0.0015128	0.0201796
SLURP1	-1.7935469	0.0003667	0.0086078
TRBV4-2	-1.7882811	0.0000122	0.0011873
IGHG4	-1.6651710	0.0014029	0.0193048
PRSS27	-1.6101254	0.0000000	0.0000010
OPN1SW	-1.5957304	0.0010852	0.0166257
FENDRR	-1.3582936	0.0005712	0.0111520
HOPX	-1.2004463	0.0000000	0.0000003
ANXA9	-1.1863015	0.0000000	0.0000225
SOGA3	-1.1492763	0.0000050	0.0007196
RP11-64C1.1	-1.1236122	0.0002747	0.0073143
TRAV4	-1.1165131	0.0006128	0.0116053
DOK5	-1.0939985	0.0000523	0.0028516
TMEM145	-1.0712583	0.0002076	0.0062665
ZNF728	-1.0521973	0.0043615	0.0382570
KISS1	-1.0231259	0.0000045	0.0006861
CNFN	-1.0093486	0.0000004	0.0001590
TRAV21	-1.0008325	0.0011965	0.0176970
TGM3	-0.9997551	0.0000000	0.0000090
ABCG2	-0.9948421	0.0000004	0.0001513
RP11-250H24.4	-0.9759165	0.0024518	0.0268393
DIRAS2	-0.9724012	0.0000026	0.0005001
WSCD2	-0.9716562	0.0015092	0.0201796
SLC4A10	-0.9445816	0.0003535	0.0084306
CYP4F22	-0.9350872	0.0005134	0.0105094
GABRD	-0.9303349	0.0008577	0.0144304
PCOLCE2	-0.9291663	0.0030267	0.0304347
RP11-377G16.2	-0.9270751	0.0020774	0.0243381
GCOM1	-0.9066369	0.0000031	0.0005595
ALOX12	-0.8962265	0.0000466	0.0026593
RP1-214M20.2	-0.8847713	0.0000144	0.0012903
TM4SF19.1	-0.8822887	0.0060362	0.0462842
SFTPD	-0.8781367	0.0000018	0.0003930
SPARCL1	-0.8767599	0.0000007	0.0002323
RP11-875H7.5	-0.8634227	0.0009141	0.0149692
GPM6A	-0.8609836	0.0006162	0.0116407
TRGV4	-0.8596803	0.0017601	0.0219497
TRBV20-1	-0.8572522	0.0013399	0.0187906
FABP3	-0.8390524	0.0065172	0.0485614
LRCH2	-0.8287418	0.0005165	0.0105484
RP11-493K19.3	-0.8224368	0.0000654	0.0032312
LYPD1	-0.8221815	0.0000005	0.0001722
GRIK1	-0.8071296	0.0000590	0.0030600
OR51E2	-0.8057666	0.0007976	0.0136894
GRID1	-0.8056541	0.0000616	0.0031605
HHIP	-0.7990500	0.0000452	0.0026455
C21orf88	-0.7950731	0.0017756	0.0220915
CTD-2626G11.2	-0.7946462	0.0000249	0.0017812
HLA-DQB2	-0.7889908	0.0002631	0.0071085
A2ML1	-0.7834005	0.0044364	0.0386373
CYS1	-0.7766507	0.0000205	0.0015617
ZNF835	-0.7660486	0.0003671	0.0086078
RP1-302D9.3	-0.7657790	0.0002659	0.0071756
RP11-215H22.1	-0.7632948	0.0002108	0.0062863
KIF12	-0.7590129	0.0006999	0.0125690
MC4R	-0.7565352	0.0012489	0.0181279
CRTAM	-0.7532744	0.0001553	0.0053904
ZNF385B	-0.7483271	0.0022363	0.0253666
FLT4	-0.7464879	0.0052498	0.0425079
AC002456.2	-0.7454221	0.0008882	0.0147313
GPC3	-0.7431350	0.0000008	0.0002460
GABBR2	-0.7405785	0.0001379	0.0050188
TMPRSS11A	-0.7390167	0.0051653	0.0422233
TBX4	-0.7351109	0.0006565	0.0120741
SCGB3A1	-0.7348552	0.0005690	0.0111492
SCGB1A1	-0.7342287	0.0056071	0.0442569
TMPRSS11E	-0.7332024	0.0006886	0.0124607
CTXN3	-0.7328341	0.0041174	0.0368094
TMPRSS11F	-0.7327097	0.0067088	0.0493200
RP11-73M7.6	-0.7302310	0.0025263	0.0272698
KCNJ1	-0.7226517	0.0008292	0.0140521
CAMK2N1	-0.7168096	0.0000114	0.0011414
CD52	-0.7147869	0.0009119	0.0149692
ISLR	-0.7081926	0.0000080	0.0009471
NPPC	-0.7066265	0.0000816	0.0036453
SLC6A13	-0.7023833	0.0002920	0.0076297
MFAP4	-0.6926880	0.0014551	0.0197597
SLC5A7	-0.6912281	0.0001584	0.0054604
C2orf72	-0.6864001	0.0037487	0.0347841
RPL32P1	-0.6757923	0.0021953	0.0250980
KRT4	-0.6741877	0.0040932	0.0367187
JAM2	-0.6728379	0.0012574	0.0182066
SCUBE1	-0.6722157	0.0002405	0.0068286
CTSW	-0.6650400	0.0008849	0.0147150
STAC	-0.6637347	0.0012836	0.0183927
AC068831.3	-0.6612633	0.0040383	0.0363660
BPI	-0.6593759	0.0002061	0.0062665
DUSP26	-0.6587218	0.0002169	0.0063910
EMP1	-0.6578094	0.0007782	0.0135407
FEZF2	-0.6554235	0.0029164	0.0297500
C6orf229	-0.6545682	0.0061458	0.0467481
PLA2G1B	-0.6545144	0.0028344	0.0292210
CLEC4F	-0.6535467	0.0003011	0.0077735
ACOXL	-0.6446535	0.0000925	0.0039035
KCNA3	-0.6443652	0.0002871	0.0075340
RP11-307C19.1	-0.6438555	0.0035422	0.0335697
ST6GAL2	-0.6418108	0.0000024	0.0004794
RP4-785G19.5	-0.6416908	0.0021960	0.0250980
CTC-260E6.6	-0.6414205	0.0013201	0.0186358
TRAC	-0.6399490	0.0001824	0.0059236
P4HA3	-0.6391167	0.0001123	0.0044235
EEF1A1P13	-0.6388126	0.0000029	0.0005433
MEIOB	-0.6382258	0.0046355	0.0396591
MYZAP	-0.6282005	0.0022378	0.0253718
CLCA4	-0.6257042	0.0014691	0.0198866
ADAMTSL1	-0.6256839	0.0000280	0.0019072
GPR174	-0.6240299	0.0001287	0.0048256
JAKMIP2	-0.6153699	0.0004362	0.0095129
DLC1	-0.6152811	0.0024294	0.0267082
SMTNL2	-0.6109394	0.0022274	0.0253102
DMRT1	-0.6096933	0.0034794	0.0331327
CYP2W1	-0.6084916	0.0004378	0.0095225
SYT13	-0.6082086	0.0001410	0.0050749
GPR124	-0.6075574	0.0005623	0.0110796
RP11-284N8.3	-0.6071607	0.0007323	0.0129842
RP11-239E10.2	-0.6071463	0.0000102	0.0010914
SLC7A14	-0.6069894	0.0033177	0.0321168
BEX1	-0.6049220	0.0006089	0.0115753
TSPAN18	-0.6046893	0.0037386	0.0347536
CPB2-AS1	-0.5960951	0.0022490	0.0254654
CD207	-0.5914865	0.0007423	0.0130941
LEPR	-0.5863591	0.0009848	0.0156428
KCNJ6	-0.5856257	0.0003463	0.0083552
FCRL6	-0.5850643	0.0061356	0.0467069
KCNK3	-0.5835709	0.0004749	0.0100396
CX3CR1	-0.5829135	0.0007260	0.0128821
FRRS1L	-0.5827754	0.0047766	0.0403116
KRT17P2	-0.5813198	0.0041036	0.0367523
ADH1B	-0.5805016	0.0000050	0.0007196
ITM2A	-0.5803643	0.0001585	0.0054604
ZNF114	-0.5789884	0.0008611	0.0144786
CDH7	-0.5785158	0.0021593	0.0248669
RAMP2	-0.5784359	0.0000124	0.0011976
KIAA0408	-0.5783474	0.0008939	0.0147609
AC007347.1	-0.5748353	0.0001597	0.0054860
CCL5	-0.5740615	0.0016482	0.0212110
NPBWR1	-0.5722081	0.0042003	0.0372118
RP4-635E18.6	-0.5721799	0.0005734	0.0111693
PEG10	-0.5712589	0.0000176	0.0014563
CNGA1	-0.5691645	0.0002345	0.0067324
TRGC2	-0.5684042	0.0020908	0.0244379
DDC	-0.5649902	0.0008754	0.0146235
SKAP1	-0.5636253	0.0000010	0.0002639
SEC14L3	-0.5633833	0.0046436	0.0396887
PPFIA2	-0.5622687	0.0005713	0.0111520
NDRG4	-0.5620810	0.0000066	0.0008342
QPRT	-0.5580279	0.0000128	0.0012152
TSPAN7	-0.5579895	0.0002001	0.0061642
HLA-DOA	-0.5576637	0.0043708	0.0382805
APOBEC3H	-0.5544878	0.0002150	0.0063758
AC020571.3	-0.5543959	0.0048194	0.0405436
UBE2QL1	-0.5516127	0.0000493	0.0027462
MYOZ1	-0.5512993	0.0001388	0.0050445
RUNX1T1	-0.5498136	0.0001105	0.0043950
LINC01140	-0.5451518	0.0017522	0.0219488
IFIT1	-0.5442635	0.0000943	0.0039184
CSTF3-AS1	-0.5435079	0.0002272	0.0065993
PADI3	-0.5398219	0.0015904	0.0207453
LGR5	-0.5377769	0.0044125	0.0385223
CH25H	-0.5372711	0.0000388	0.0024265
AP001347.6	-0.5361103	0.0002610	0.0070739
OASL	-0.5355939	0.0056885	0.0447076
SNCG	-0.5345337	0.0001499	0.0052986
CTD-2135D7.2	-0.5325317	0.0049373	0.0411311
ROBO2	-0.5306888	0.0000302	0.0020068
ADH1C	-0.5276992	0.0000063	0.0008142
RP11-389K14.3	-0.5272550	0.0019921	0.0237275
SCG5	-0.5272260	0.0023872	0.0264362
EMID1	-0.5267117	0.0001908	0.0060443
CYP2F1	-0.5218862	0.0000223	0.0016607
LINC00996	-0.5195705	0.0015679	0.0205904
APOBEC2	-0.5192123	0.0049521	0.0412149
KCNA4	-0.5187887	0.0012753	0.0183303
RP11-568A7.2	-0.5180328	0.0004542	0.0097729
RP4-564M11.2	-0.5179555	0.0024962	0.0270719
AC027601.1	-0.5166162	0.0029202	0.0297500
AC226118.1	-0.5162691	0.0004802	0.0101065
AC005082.12	-0.5158740	0.0009718	0.0155756
HLF	-0.5155131	0.0000016	0.0003844
NAP1L3	-0.5151662	0.0001883	0.0060014
LRP1B	-0.5137005	0.0009156	0.0149731
SLC38A4	-0.5134971	0.0003171	0.0080114
UBASH3A	-0.5124762	0.0007353	0.0130195
FBN1	-0.5118322	0.0000458	0.0026455
CPED1	-0.5102563	0.0014392	0.0196211
CYP2A13	-0.5098383	0.0020638	0.0242722
FAM89A	-0.5095007	0.0051090	0.0419715
GJA1	-0.5094236	0.0000179	0.0014607
FGF18	-0.5087330	0.0043583	0.0382518
PROS1	-0.5079921	0.0010033	0.0157922
TRBC2	-0.5054618	0.0022070	0.0251986
DCX	-0.5051410	0.0044268	0.0385848
SMOC2	-0.5050210	0.0000904	0.0038788
FGF9	-0.5049568	0.0000228	0.0016888
CNKSR2	-0.5044825	0.0000795	0.0036006
VSTM4	-0.5034349	0.0003624	0.0085426
KLRK1	-0.5032737	0.0017614	0.0219497
ECM2	-0.5032527	0.0000352	0.0022391
CD8B	-0.5011585	0.0038495	0.0353345
KIAA1462	-0.5010617	0.0020661	0.0242722

# write.table(resSigDown, "20201112_Up_in_COPD_Bronch.txt", sep = "\t", quote=F)

Differentially expressed in non-COPD patients

resSigUp <- resSig[resSig$log2FoldChange > 0.5, ]
resSigUp <- resSigUp[order(resSigUp$log2FoldChange, decreasing = T),]
resSigUp <- resSigUp[,c(2,5,6)]
colnames(resSigUp) <- c("Log2FC", "P-value", "Adj. P-value")
resSigUp %>%
  knitr::kable(
    format = "html", align = rep("c", ncol(resSig) + 1),
    row.names = TRUE
  ) %>%
  kableExtra::kable_styling() %>%
  kableExtra::scroll_box(height = "300px")

	Log2FC	P-value	Adj. P-value
STC1	2.2802176	0.0000000	0.0000010
SLC6A10P	2.1910697	0.0002990	0.0077433
Z82214.3	1.8690658	0.0000007	0.0002348
BPIFB6	1.8233056	0.0000004	0.0001674
CTD-3118D7.1	1.7859920	0.0000187	0.0014889
MUC3A	1.7289481	0.0000056	0.0007643
APOB	1.6658811	0.0000000	0.0000118
PAX6	1.6033870	0.0004596	0.0098152
MUC6	1.5711397	0.0000025	0.0004803
TPO	1.5209755	0.0000000	0.0000006
DPCR1	1.4355268	0.0003097	0.0079349
ARHGAP40	1.4010723	0.0000000	0.0000020
PCDH15	1.3451918	0.0024073	0.0265214
BPIFB2	1.3307664	0.0000035	0.0005948
IL17REL	1.3159170	0.0000000	0.0000094
CACNA1E	1.3158698	0.0000000	0.0000000
GRM7-AS1	1.3097725	0.0007791	0.0135428
RP11-167N4.2	1.3036335	0.0000007	0.0002298
SLC13A5	1.3022798	0.0000004	0.0001513
ALOX15B	1.2553555	0.0000121	0.0011855
REG4	1.2536849	0.0000646	0.0032187
CREG2	1.2522371	0.0001457	0.0051982
EDN2	1.2235233	0.0028463	0.0292864
C8orf22	1.2221970	0.0027706	0.0288886
SNTG2	1.2159686	0.0000000	0.0000011
BMP8A	1.2121615	0.0003433	0.0083281
RP11-139K4.2	1.2103870	0.0000380	0.0023818
CSF3	1.2078871	0.0001984	0.0061280
RP11-138A9.2	1.2018027	0.0004080	0.0092355
RP11-157E16.1	1.1889221	0.0000788	0.0035892
ANO7	1.1720775	0.0000000	0.0000003
PIRT	1.1661742	0.0009810	0.0156338
CHRM1	1.1586391	0.0000700	0.0033416
RP11-481N16.1	1.1430760	0.0004337	0.0094744
SLC25A48	1.1391164	0.0000179	0.0014607
RP11-567M16.2	1.1180493	0.0003396	0.0082711
AL133373.1	1.1147990	0.0000000	0.0000011
C1orf95	1.1137259	0.0000011	0.0002981
FAM189A1	1.1130344	0.0059601	0.0459847
HKDC1	1.1095670	0.0000003	0.0001342
GAPDHP24	1.1079986	0.0007809	0.0135542
PXDN	1.1079226	0.0000000	0.0000010
ZDHHC4P1	1.1075640	0.0000000	0.0000147
CDH15	1.1048649	0.0000497	0.0027612
PTHLH	1.0995579	0.0000000	0.0000261
RP11-89K21.1	1.0968992	0.0012437	0.0180929
LIPG	1.0812755	0.0000066	0.0008342
NTRK2	1.0642048	0.0000002	0.0000909
SIX3	1.0582863	0.0000797	0.0036006
RP11-779P15.2	1.0565586	0.0014002	0.0192783
PMS2P10	1.0392064	0.0028860	0.0295173
IL19	1.0178270	0.0000120	0.0011728
RP11-439L8.3	1.0156225	0.0000199	0.0015513
AC012501.2	1.0101285	0.0036346	0.0341523
B3GNT6	1.0066858	0.0000423	0.0025675
RP11-139K4.4	1.0000498	0.0000007	0.0002298
RP11-333O1.1	0.9979751	0.0049601	0.0412358
AQP7P1	0.9953444	0.0004687	0.0099612
SLCO1B7	0.9935182	0.0018572	0.0226495
AL354898.1	0.9930726	0.0043948	0.0384051
RP11-687D19.1	0.9878544	0.0007001	0.0125690
LEFTY1	0.9865289	0.0011539	0.0173171
STXBP5L	0.9817248	0.0002391	0.0068094
MICD	0.9804493	0.0000369	0.0023211
RP11-507B12.1	0.9629970	0.0021586	0.0248669
FLNC	0.9619265	0.0000049	0.0007152
CGREF1	0.9614465	0.0002335	0.0067105
GOLGA6B	0.9595250	0.0005255	0.0106222
SLCO1B3	0.9548557	0.0000436	0.0025946
DUSP5P1	0.9477895	0.0000039	0.0006309
GOLGA7B.1	0.9423668	0.0029528	0.0299979
RP11-16E12.2	0.9416867	0.0001018	0.0041658
FEZF1	0.9287649	0.0063670	0.0479009
FKBP5	0.9227220	0.0000001	0.0000508
NPM1P43	0.9211773	0.0005307	0.0106798
RP11-460N11.3	0.9182599	0.0015595	0.0205364
ZNF467	0.9166568	0.0000000	0.0000168
RP11-395B7.2	0.9164471	0.0000334	0.0021484
CTD-2509G16.3	0.9162443	0.0004330	0.0094744
U3.80	0.9097359	0.0030444	0.0305769
RP11-115D19.1	0.9084628	0.0004273	0.0093990
SSPO	0.9080064	0.0000000	0.0000132
RP11-439L8.4	0.9058979	0.0000470	0.0026637
RP11-139K4.1	0.8914952	0.0000001	0.0000379
CDSN	0.8871000	0.0026822	0.0282420
CYP17A1	0.8842914	0.0037402	0.0347536
EPS8L3	0.8830837	0.0009908	0.0156741
SLC6A1	0.8814102	0.0050176	0.0415311
AC015987.2	0.8711021	0.0004431	0.0095905
FBN2	0.8683692	0.0000000	0.0000168
LINC00342	0.8683322	0.0000044	0.0006793
RP1-37C10.3	0.8666098	0.0023047	0.0258569
RPL21P112	0.8656450	0.0022159	0.0252246
FAM177B	0.8630706	0.0000044	0.0006793
RP11-838N2.8	0.8565901	0.0006507	0.0120028
IDI2-AS1	0.8553067	0.0010945	0.0167282
COMP	0.8533607	0.0020652	0.0242722
C1QTNF1	0.8525928	0.0009821	0.0156338
AZGP1	0.8478495	0.0000006	0.0002136
RP11-803D5.4	0.8453177	0.0000236	0.0017277
EEF1DP5	0.8400569	0.0006702	0.0122548
AHSG	0.8369773	0.0048318	0.0406150
AC098592.7	0.8330522	0.0001233	0.0047183
RP5-914M6.1	0.8324801	0.0004806	0.0101065
YAP1P1	0.8279149	0.0032406	0.0317538
MTND4P12	0.8259292	0.0002818	0.0074391
CTB-102L5.8	0.8249917	0.0032962	0.0319930
ITGA10	0.8216204	0.0000006	0.0001949
FIGN	0.8176383	0.0000005	0.0001701
RP11-10H3.1	0.8162534	0.0031539	0.0312348
LRRC31	0.8142625	0.0000077	0.0009200
RP11-386M24.5	0.8137338	0.0034447	0.0328752
AC144450.2	0.8112034	0.0000000	0.0000071
RP11-527N22.1	0.8083172	0.0011072	0.0168221
FAM157B	0.8075813	0.0024752	0.0269577
CUX2	0.8075334	0.0000302	0.0020068
RP11-194N12.2	0.8062291	0.0013692	0.0190958
RN7SKP151	0.8049246	0.0001865	0.0059830
WNT16	0.7989340	0.0007900	0.0135948
RP11-80I15.1	0.7961854	0.0000128	0.0012152
ASNSP3	0.7943701	0.0000018	0.0003930
SEMA6B	0.7933276	0.0023853	0.0264362
TDGF1P4	0.7871098	0.0050168	0.0415311
BCAS2P2	0.7851954	0.0000628	0.0031821
SLC17A9	0.7810516	0.0000018	0.0003930
RPLP0P2	0.7810449	0.0004219	0.0093284
ENTPD2	0.7809707	0.0000000	0.0000020
WDR72	0.7799025	0.0000022	0.0004537
GOLGA6L10	0.7788106	0.0032463	0.0317728
RNU5E-6P	0.7765796	0.0005455	0.0108481
RP11-508M8.1	0.7727333	0.0050119	0.0415311
AQP7P3	0.7713275	0.0001727	0.0057324
RP11-893F2.9	0.7663894	0.0005455	0.0108481
GOLGA7B	0.7663690	0.0001983	0.0061280
U3.7	0.7658721	0.0024289	0.0267082
MUC5AC	0.7652430	0.0001773	0.0058281
GPR153	0.7650752	0.0000055	0.0007643
LDLRAD2	0.7645421	0.0000000	0.0000168
DAAM2	0.7630483	0.0000828	0.0036453
AC124944.4	0.7617858	0.0056907	0.0447113
LINC00632	0.7602183	0.0004096	0.0092459
LA16c-425C2.1	0.7582489	0.0000827	0.0036453
CTD-2530H12.7	0.7573317	0.0001009	0.0041363
CTD-2267D19.6	0.7553498	0.0001489	0.0052847
CTD-3193O13.1	0.7541919	0.0000709	0.0033736
CCL24	0.7527081	0.0061780	0.0468771
F5	0.7490325	0.0000011	0.0002858
RP11-2E11.5	0.7475000	0.0058795	0.0455949
RN7SL105P	0.7472610	0.0004983	0.0103240
AZGP1P1	0.7417958	0.0044137	0.0385223
RP4-713A8.1	0.7396379	0.0008328	0.0140956
C2CD4A	0.7374139	0.0000440	0.0026061
AC073218.2	0.7307830	0.0011322	0.0171098
PTGS2	0.7289908	0.0001296	0.0048450
RP11-5L12.1	0.7274469	0.0048803	0.0408152
DOC2B	0.7263661	0.0006268	0.0117429
AC020907.1	0.7245049	0.0007369	0.0130391
ZBTB16	0.7241821	0.0009144	0.0149692
AC138035.1	0.7223241	0.0015351	0.0203407
DHRSX-IT1	0.7172868	0.0001475	0.0052562
PHACTR3	0.7168333	0.0027491	0.0287316
NANOGP7	0.7152823	0.0000585	0.0030453
ELMOD1	0.7129683	0.0000658	0.0032312
SERHL2	0.7126315	0.0000061	0.0007998
RP11-589C21.6	0.7122100	0.0001930	0.0060647
BRINP1	0.7089327	0.0044142	0.0385223
AC006003.3	0.7085877	0.0011863	0.0176073
RP11-259O2.1	0.7085502	0.0014797	0.0199352
NEAT1	0.7069154	0.0000003	0.0001512
KCNN2	0.7055893	0.0035739	0.0337575
RPS20P1	0.7052842	0.0001361	0.0049878
CYP3A5	0.7025365	0.0002024	0.0062135
CPNE4	0.6971037	0.0001367	0.0049968
RP13-726E6.3	0.6968872	0.0036570	0.0342778
RN7SL739P	0.6968854	0.0013355	0.0187499
PTPRH	0.6967019	0.0002416	0.0068441
DNAJC12	0.6965788	0.0000185	0.0014859
RP11-386M24.6	0.6947778	0.0003637	0.0085553
AC108066.1	0.6927396	0.0046537	0.0397125
TNNI3	0.6895294	0.0000024	0.0004780
REP15	0.6863976	0.0000160	0.0013776
RP11-430B1.1	0.6826777	0.0020739	0.0243187
AP000695.6	0.6807910	0.0022200	0.0252484
Metazoa_SRP.12	0.6768366	0.0002958	0.0076932
ADRA2A	0.6753578	0.0001356	0.0049763
TMC7	0.6732001	0.0000001	0.0000729
ENTPD8	0.6707694	0.0000173	0.0014488
RP11-221J22.2	0.6689997	0.0005659	0.0111150
FDPSP3	0.6672645	0.0000805	0.0036201
AF131215.6	0.6663677	0.0030051	0.0303008
TFF1	0.6656251	0.0025258	0.0272698
CTD-2589M5.4	0.6655705	0.0002820	0.0074391
RP11-10J21.4	0.6623944	0.0064718	0.0483631
RP11-480G7.1	0.6612726	0.0000525	0.0028516
RP4-609E1.2	0.6612028	0.0018409	0.0225540
CTC-548K16.6	0.6606675	0.0000891	0.0038393
RN7SL57P	0.6600234	0.0000669	0.0032721
RP11-77H9.5	0.6588525	0.0001544	0.0053875
FAM157C	0.6576799	0.0000098	0.0010757
RP3-363L9.1	0.6566384	0.0007351	0.0130195
RP11-47G11.2	0.6554680	0.0003918	0.0089710
RP11-74C1.2	0.6540906	0.0000186	0.0014882
JAKMIP3	0.6540259	0.0012947	0.0184917
RP11-120K24.4	0.6534771	0.0000032	0.0005713
RP11-435B5.5	0.6517619	0.0020961	0.0244481
CTD-2047H16.2	0.6473474	0.0002744	0.0073122
CEACAM5	0.6468732	0.0031817	0.0313801
AP000889.3	0.6445893	0.0048654	0.0407301
SPDEF	0.6439825	0.0000319	0.0020723
RP5-981O7.2	0.6436388	0.0000003	0.0001390
AC078852.2	0.6426335	0.0022135	0.0252246
MUC1	0.6426249	0.0000000	0.0000043
AC007036.4	0.6424753	0.0000354	0.0022431
RP11-18F14.4	0.6418176	0.0011714	0.0174781
SLC26A2	0.6402932	0.0000001	0.0000508
THBS1	0.6378750	0.0000419	0.0025579
CATSPERB	0.6363337	0.0000000	0.0000135
SULT1C2	0.6336007	0.0010821	0.0166011
CTB-193M12.3	0.6329112	0.0002520	0.0069591
RP11-496D24.2	0.6324266	0.0028561	0.0293635
AC092168.2	0.6323481	0.0001051	0.0042738
RP11-297K8.2	0.6299306	0.0009634	0.0154737
PNCK	0.6294998	0.0004467	0.0096363
RP11-1191J2.2	0.6282962	0.0029801	0.0301316
AC008132.13	0.6267860	0.0008807	0.0146735
AC112518.3	0.6239440	0.0000113	0.0011414
RN7SKP95	0.6213521	0.0013808	0.0191326
RP11-864J10.2	0.6212002	0.0016983	0.0214305
GS1-122H1.3	0.6194692	0.0028910	0.0295551
CHCHD4P2	0.6188037	0.0003137	0.0079707
KCP	0.6187811	0.0024825	0.0270084
ADM2	0.6179245	0.0000016	0.0003661
VN1R51P	0.6168663	0.0005712	0.0111520
SLC25A18	0.6168032	0.0036173	0.0340919
RN7SKP24	0.6162040	0.0000692	0.0033167
RP11-447H19.3	0.6160178	0.0045266	0.0390912
UNC5A	0.6151160	0.0059948	0.0461162
CTC-244M17.1	0.6149821	0.0000424	0.0025675
SERPINB4	0.6147896	0.0006177	0.0116526
NID2	0.6133132	0.0052442	0.0425079
CTD-2589H19.6	0.6127672	0.0026819	0.0282420
ADORA3	0.6125718	0.0004376	0.0095225
TMEM211	0.6123906	0.0000039	0.0006283
RP11-168F9.2	0.6078583	0.0044876	0.0389508
PRSS16	0.6077625	0.0000000	0.0000236
AL627309.1	0.6074216	0.0011047	0.0168054
NARF-IT1	0.6071972	0.0000040	0.0006422
RP11-1036E20.9	0.6062101	0.0000001	0.0000502
RP11-380J14.1	0.6057669	0.0000212	0.0016032
RP11-458F8.2	0.6055018	0.0033041	0.0320429
RP11-324E6.6	0.6049054	0.0053533	0.0429934
RPS4XP22	0.6033927	0.0007829	0.0135542
RP11-797A18.4	0.6032046	0.0000004	0.0001627
AC016559.1	0.6028178	0.0015340	0.0203407
IRAK3	0.6021432	0.0000000	0.0000251
SHROOM1	0.6003467	0.0000014	0.0003441
RP11-3K24.1	0.5998078	0.0013500	0.0189014
TCN1	0.5989780	0.0019457	0.0233376
MYLK3	0.5987669	0.0001154	0.0045048
RP11-164H5.1	0.5984192	0.0003574	0.0084713
RP11-49O14.3	0.5980525	0.0000104	0.0011029
HK2P1	0.5974026	0.0040816	0.0366273
AC138517.1	0.5959937	0.0040339	0.0363522
RP11-112L18.1	0.5952027	0.0020410	0.0241032
ATP5A1P3	0.5946478	0.0000096	0.0010602
ANKRD36C	0.5933542	0.0004807	0.0101065
CTD-2547H18.1	0.5928804	0.0010601	0.0163950
PLEKHD1	0.5911511	0.0003312	0.0081736
RP11-359B20.1	0.5908479	0.0001330	0.0049102
RPL7L1P2	0.5905607	0.0000305	0.0020171
PYCR1	0.5900049	0.0000047	0.0007035
LBX2	0.5895572	0.0003346	0.0082269
AC005077.14	0.5888899	0.0000005	0.0001878
RP11-131K5.1	0.5877011	0.0012684	0.0182802
DQX1	0.5870439	0.0000000	0.0000168
CTB-11I22.2	0.5844118	0.0004153	0.0092943
AC110619.1	0.5820199	0.0002023	0.0062135
LAP3P1	0.5799572	0.0000106	0.0011099
AC144450.1	0.5798538	0.0010304	0.0160632
GS1-122H1.1	0.5794545	0.0032951	0.0319930
RN7SKP239	0.5790295	0.0003293	0.0081676
ADAMDEC1	0.5787993	0.0028423	0.0292803
RP11-195B21.3	0.5758041	0.0010020	0.0157841
RP11-27M24.2	0.5755681	0.0056420	0.0444645
AP001468.1	0.5747175	0.0065673	0.0488126
CXCL2	0.5733062	0.0053491	0.0429866
CCDC144NL	0.5717484	0.0055756	0.0441309
RP11-100J16.4	0.5713423	0.0028455	0.0292864
RP11-381G8.1	0.5713423	0.0028455	0.0292864
AC097468.4	0.5709202	0.0011236	0.0170010
PRKXP1	0.5706856	0.0039136	0.0356553
CTHRC1	0.5698637	0.0065886	0.0488952
RP11-486O13.4	0.5694970	0.0027173	0.0284954
RP11-353J17.3	0.5691443	0.0002440	0.0068717
ITPKB-IT1	0.5680758	0.0023671	0.0262924
RP11-332H18.3	0.5664058	0.0003317	0.0081736
RP5-1041C10.3	0.5660460	0.0000057	0.0007752
CPE	0.5652087	0.0001208	0.0046461
ABO	0.5647148	0.0000169	0.0014221
BACE2-IT1	0.5637973	0.0022528	0.0254731
RP11-554D13.1	0.5629611	0.0060048	0.0461318
PSORS1C1	0.5608379	0.0051067	0.0419715
RP3-342P20.2	0.5603868	0.0000796	0.0036006
JPH2	0.5601865	0.0012032	0.0177501
AF131215.4	0.5587864	0.0000001	0.0000536
PLAT	0.5580129	0.0012985	0.0185031
MSLN	0.5576314	0.0000032	0.0005681
NDUFB8P2	0.5574481	0.0021651	0.0249220
GPR37	0.5561644	0.0003205	0.0080581
RP11-534P19.1	0.5545697	0.0046406	0.0396764
AC017060.1	0.5533333	0.0005884	0.0113528
AC009061.1	0.5531123	0.0004010	0.0091407
RPS16P5	0.5518405	0.0000625	0.0031779
CTD-2201E18.5	0.5511306	0.0022534	0.0254731
RP11-555K12.2	0.5511138	0.0066352	0.0490284
CHAD	0.5510209	0.0000543	0.0029294
BHLHA15	0.5503049	0.0010218	0.0159781
AC114737.3	0.5494690	0.0007919	0.0136089
C1orf64	0.5492243	0.0046336	0.0396561
AC091171.1	0.5492018	0.0004867	0.0101666
STEAP3-AS1	0.5467683	0.0013243	0.0186633
PDCL3P6	0.5466952	0.0041412	0.0369561
AC015987.1	0.5464583	0.0007862	0.0135833
RP13-870H17.3	0.5459774	0.0009544	0.0153929
CTD-2547L24.4	0.5459735	0.0063446	0.0477885
RP11-680G24.4	0.5449092	0.0040439	0.0363866
FTLP14	0.5435340	0.0012977	0.0185015
CTA-331F8.1	0.5412948	0.0017231	0.0216636
RP11-317F20.2	0.5395444	0.0003681	0.0086214
RP1-168P16.1	0.5394518	0.0027531	0.0287532
LCN2	0.5391316	0.0015233	0.0202679
RP11-99A1.2	0.5390547	0.0000056	0.0007711
BTNL9	0.5387906	0.0011193	0.0169565
RP11-214O1.3	0.5385319	0.0003153	0.0079869
XBP1P1	0.5381186	0.0003394	0.0082711
RP11-21A7A.3	0.5374270	0.0020428	0.0241081
RP11-982M15.8	0.5353255	0.0022764	0.0256514
RTEL1-TNFRSF6B	0.5348836	0.0000468	0.0026593
RP11-241J12.3	0.5344845	0.0012507	0.0181433
IL1R2	0.5343087	0.0022972	0.0258175
CTD-2555A7.2	0.5332711	0.0052197	0.0424117
HCG20	0.5328531	0.0045142	0.0390235
RP11-327F22.6	0.5318638	0.0063726	0.0479036
RP11-34P13.13	0.5315750	0.0000275	0.0018786
CYP1B1-AS1	0.5315748	0.0016838	0.0213630
RP11-318K15.2	0.5314635	0.0006216	0.0116919
AC026806.2	0.5310165	0.0000008	0.0002426
RP11-1396O13.2	0.5301164	0.0016456	0.0212110
RP11-449P15.1	0.5300198	0.0005871	0.0113420
NKX3-1	0.5288490	0.0020963	0.0244481
HSD11B2	0.5277233	0.0001276	0.0047993
KLF7-IT1	0.5277020	0.0000275	0.0018786
RP11-206L10.3	0.5274511	0.0000180	0.0014607
ALDH1L2	0.5271217	0.0003375	0.0082498
RP11-68I3.11	0.5252756	0.0000564	0.0029806
AC139426.2	0.5245291	0.0001720	0.0057243
RP11-356M20.3	0.5233429	0.0004226	0.0093351
PDPK2	0.5219127	0.0000106	0.0011099
RP11-384C4.6	0.5215964	0.0000887	0.0038302
CTD-3222D19.5	0.5213488	0.0042189	0.0373421
GRM8	0.5205974	0.0022475	0.0254600
RP11-158M2.5	0.5205745	0.0055090	0.0437515
LINC01002	0.5194631	0.0011715	0.0174781
OMP	0.5187381	0.0046976	0.0399109
RP11-553A21.3	0.5182660	0.0055072	0.0437513
RP11-443F16.1	0.5181958	0.0020657	0.0242722
AP000347.4	0.5180575	0.0013345	0.0187456
RP11-231C14.4	0.5180177	0.0000414	0.0025355
CTB-181H17.1	0.5175276	0.0001863	0.0059830
AC000089.3	0.5168444	0.0000009	0.0002534
CTD-2619J13.8	0.5165587	0.0051089	0.0419715
RP11-453A12.1	0.5162805	0.0027785	0.0289363
RP11-422N16.3	0.5149038	0.0000462	0.0026553
RP11-458F8.4	0.5148342	0.0015087	0.0201796
HMSD	0.5148289	0.0018162	0.0223798
CTB-131B5.2	0.5146960	0.0001450	0.0051884
RP11-305L7.5	0.5146866	0.0033579	0.0323840
GJA6P	0.5146277	0.0002493	0.0069157
SYT8	0.5140831	0.0000748	0.0035025
FOXA3	0.5140588	0.0001090	0.0043815
AC010525.7	0.5138022	0.0001906	0.0060443
RAB43	0.5137079	0.0000003	0.0001463
RP1-308E4.1	0.5136772	0.0065726	0.0488182
LINC00930	0.5129701	0.0016766	0.0213349
FUT6	0.5123183	0.0000002	0.0000781
RP11-404P21.5	0.5120947	0.0021083	0.0245224
RP11-392E22.12	0.5120726	0.0000154	0.0013398
RABGAP1L-IT1	0.5120653	0.0000086	0.0009878
SLC25A47P1	0.5119896	0.0000164	0.0013934
RP11-281P23.2	0.5117555	0.0016227	0.0210554
NEK6	0.5112889	0.0000001	0.0000388
RP11-1082L8.1	0.5106343	0.0047585	0.0402320
AC019117.2	0.5103779	0.0007883	0.0135935
CTB-11I22.1	0.5102449	0.0062128	0.0470565
RP11-392E22.5	0.5101933	0.0004160	0.0092992
RP11-305O4.2	0.5101464	0.0003069	0.0079015
RP11-982M15.6	0.5099017	0.0028238	0.0291830
AC138035.2	0.5098157	0.0007431	0.0130941
AK4P4	0.5090954	0.0049702	0.0412850
RP1-313L4.3	0.5090926	0.0060696	0.0464247
RN7SL23P	0.5087898	0.0010104	0.0158478
RP11-365D23.4	0.5074868	0.0016455	0.0212110
ARMC12	0.5071957	0.0029788	0.0301316
ATP10B	0.5065195	0.0026248	0.0279122
SLC16A14	0.5055594	0.0000393	0.0024466
RP11-16E23.3	0.5046668	0.0001399	0.0050487
ANKRD18A.1	0.5043259	0.0000334	0.0021484
TFCP2L1	0.5041815	0.0001626	0.0055436
CDC42EP5	0.5038609	0.0000471	0.0026642
RP11-163G10.2	0.5033655	0.0001262	0.0047751
PKHD1L1	0.5028688	0.0028809	0.0294831
PPIAP10	0.5027406	0.0004188	0.0093152
CTC-251D13.1	0.5026642	0.0009107	0.0149607
SEMA3B	0.5020373	0.0000131	0.0012259
RP1-5O6.4	0.5019920	0.0002717	0.0072760
ANO1	0.5011846	0.0007084	0.0126646
FBXO36-IT1	0.5010788	0.0003155	0.0079869
RPL19P12	0.5007875	0.0002096	0.0062863
AC005831.1	0.5003057	0.0000062	0.0008023

# write.table(resSigUp, "20201112_Down_in_COPD_Bronch.txt", sep = "\t", quote=F)

Checking for overlap between COPD signature

Differentially expressed genes were checked for overlap with the 98 genes from the COPD signature from Steiling et al, 2013

#Preprocessing. Run ahead of time and comment out when knitting Rmd
names(steilingGenes) <- "Names"
steilingSignature <- steilingGenes$Names
steilingUp <- head(steilingSignature,54)

#create mart object, this is for homo sapiens

mart <- useMart(biomart = "ensembl", dataset = "hsapiens_gene_ensembl")

upBM <- getBM(filters= "hgnc_symbol", attributes= c("ensembl_gene_id","hgnc_symbol"),values=steilingUp,mart= mart)

upBM <- upBM[upBM$ensembl_gene_id %in% rownames(assay(seBronch)),]
# write.table(upBM$ensembl_gene_id, "20201102_SteilingUp_Genelist.grp", sep = "\t", quote = F, col.names = F, row.names = F)
steilingDown <- tail(steilingSignature,44)

downBM <- getBM(filters= "hgnc_symbol", attributes= c("ensembl_gene_id","hgnc_symbol"),values=steilingDown,mart= mart)
downBM <- downBM[-32,]
# write.table(downBM$ensembl_gene_id, "20201102_SteilingDown_Genelist.grp", sep = "\t", quote = F, col.names = F, row.names = F)

#Send to GSEA 11/3/2020


#Check for overlap:
upoverlap <- sum(downBM$hgnc_symbol %in% rownames(resSigUp))
upoverlapgenes <- downBM$hgnc_symbol[downBM$hgnc_symbol %in% rownames(resSigUp)]
downoverlap <- sum(upBM$hgnc_symbol %in% rownames(resSigDown))
downoverlapgenes <- upBM$hgnc_symbol[upBM$hgnc_symbol %in% rownames(resSigDown)]

Overall, of the 54 genes associated with increase of COPD status, 0 were differentially expressed in patients considered to be of COPD status. These are: . Of the 44 genes associated with decrease of COPD status, 0 were differentially expressed in patients considered to be of COPD status. These are: .

Overlap with microarray

resSigUp <- read.table("20201112_Down_in_COPD_Bronch.txt", sep = "\t")
rownames(resSigUp)

##   [1] "STC1"           "SLC6A10P"       "Z82214.3"       "BPIFB6"        
##   [5] "CTD-3118D7.1"   "MUC3A"          "APOB"           "PAX6"          
##   [9] "MUC6"           "TPO"            "DPCR1"          "ARHGAP40"      
##  [13] "PCDH15"         "BPIFB2"         "IL17REL"        "CACNA1E"       
##  [17] "GRM7-AS1"       "RP11-167N4.2"   "SLC13A5"        "ALOX15B"       
##  [21] "REG4"           "CREG2"          "EDN2"           "C8orf22"       
##  [25] "SNTG2"          "BMP8A"          "RP11-139K4.2"   "CSF3"          
##  [29] "RP11-138A9.2"   "RP11-157E16.1"  "ANO7"           "PIRT"          
##  [33] "CHRM1"          "RP11-481N16.1"  "SLC25A48"       "RP11-567M16.2" 
##  [37] "AL133373.1"     "C1orf95"        "FAM189A1"       "HKDC1"         
##  [41] "GAPDHP24"       "PXDN"           "ZDHHC4P1"       "CDH15"         
##  [45] "PTHLH"          "RP11-89K21.1"   "LIPG"           "NTRK2"         
##  [49] "SIX3"           "RP11-779P15.2"  "PMS2P10"        "IL19"          
##  [53] "RP11-439L8.3"   "AC012501.2"     "B3GNT6"         "RP11-139K4.4"  
##  [57] "RP11-333O1.1"   "AQP7P1"         "SLCO1B7"        "AL354898.1"    
##  [61] "RP11-687D19.1"  "LEFTY1"         "STXBP5L"        "MICD"          
##  [65] "RP11-507B12.1"  "FLNC"           "CGREF1"         "GOLGA6B"       
##  [69] "SLCO1B3"        "DUSP5P1"        "GOLGA7B.1"      "RP11-16E12.2"  
##  [73] "FEZF1"          "FKBP5"          "NPM1P43"        "RP11-460N11.3" 
##  [77] "ZNF467"         "RP11-395B7.2"   "CTD-2509G16.3"  "U3.80"         
##  [81] "RP11-115D19.1"  "SSPO"           "RP11-439L8.4"   "RP11-139K4.1"  
##  [85] "CDSN"           "CYP17A1"        "EPS8L3"         "SLC6A1"        
##  [89] "AC015987.2"     "FBN2"           "LINC00342"      "RP1-37C10.3"   
##  [93] "RPL21P112"      "FAM177B"        "RP11-838N2.8"   "IDI2-AS1"      
##  [97] "COMP"           "C1QTNF1"        "AZGP1"          "RP11-803D5.4"  
## [101] "EEF1DP5"        "AHSG"           "AC098592.7"     "RP5-914M6.1"   
## [105] "YAP1P1"         "MTND4P12"       "CTB-102L5.8"    "ITGA10"        
## [109] "FIGN"           "RP11-10H3.1"    "LRRC31"         "RP11-386M24.5" 
## [113] "AC144450.2"     "RP11-527N22.1"  "FAM157B"        "CUX2"          
## [117] "RP11-194N12.2"  "RN7SKP151"      "WNT16"          "RP11-80I15.1"  
## [121] "ASNSP3"         "SEMA6B"         "TDGF1P4"        "BCAS2P2"       
## [125] "SLC17A9"        "RPLP0P2"        "ENTPD2"         "WDR72"         
## [129] "GOLGA6L10"      "RNU5E-6P"       "RP11-508M8.1"   "AQP7P3"        
## [133] "RP11-893F2.9"   "GOLGA7B"        "U3.7"           "MUC5AC"        
## [137] "GPR153"         "LDLRAD2"        "DAAM2"          "AC124944.4"    
## [141] "LINC00632"      "LA16c-425C2.1"  "CTD-2530H12.7"  "CTD-2267D19.6" 
## [145] "CTD-3193O13.1"  "CCL24"          "F5"             "RP11-2E11.5"   
## [149] "RN7SL105P"      "AZGP1P1"        "RP4-713A8.1"    "C2CD4A"        
## [153] "AC073218.2"     "PTGS2"          "RP11-5L12.1"    "DOC2B"         
## [157] "AC020907.1"     "ZBTB16"         "AC138035.1"     "DHRSX-IT1"     
## [161] "PHACTR3"        "NANOGP7"        "ELMOD1"         "SERHL2"        
## [165] "RP11-589C21.6"  "BRINP1"         "AC006003.3"     "RP11-259O2.1"  
## [169] "NEAT1"          "KCNN2"          "RPS20P1"        "CYP3A5"        
## [173] "CPNE4"          "RP13-726E6.3"   "RN7SL739P"      "PTPRH"         
## [177] "DNAJC12"        "RP11-386M24.6"  "AC108066.1"     "TNNI3"         
## [181] "REP15"          "RP11-430B1.1"   "AP000695.6"     "Metazoa_SRP.12"
## [185] "ADRA2A"         "TMC7"           "ENTPD8"         "RP11-221J22.2" 
## [189] "FDPSP3"         "AF131215.6"     "TFF1"           "CTD-2589M5.4"  
## [193] "RP11-10J21.4"   "RP11-480G7.1"   "RP4-609E1.2"    "CTC-548K16.6"  
## [197] "RN7SL57P"       "RP11-77H9.5"    "FAM157C"        "RP3-363L9.1"   
## [201] "RP11-47G11.2"   "RP11-74C1.2"    "JAKMIP3"        "RP11-120K24.4" 
## [205] "RP11-435B5.5"   "CTD-2047H16.2"  "CEACAM5"        "AP000889.3"    
## [209] "SPDEF"          "RP5-981O7.2"    "AC078852.2"     "MUC1"          
## [213] "AC007036.4"     "RP11-18F14.4"   "SLC26A2"        "THBS1"         
## [217] "CATSPERB"       "SULT1C2"        "CTB-193M12.3"   "RP11-496D24.2" 
## [221] "AC092168.2"     "RP11-297K8.2"   "PNCK"           "RP11-1191J2.2" 
## [225] "AC008132.13"    "AC112518.3"     "RN7SKP95"       "RP11-864J10.2" 
## [229] "GS1-122H1.3"    "CHCHD4P2"       "KCP"            "ADM2"          
## [233] "VN1R51P"        "SLC25A18"       "RN7SKP24"       "RP11-447H19.3" 
## [237] "UNC5A"          "CTC-244M17.1"   "SERPINB4"       "NID2"          
## [241] "CTD-2589H19.6"  "ADORA3"         "TMEM211"        "RP11-168F9.2"  
## [245] "PRSS16"         "AL627309.1"     "NARF-IT1"       "RP11-1036E20.9"
## [249] "RP11-380J14.1"  "RP11-458F8.2"   "RP11-324E6.6"   "RPS4XP22"      
## [253] "RP11-797A18.4"  "AC016559.1"     "IRAK3"          "SHROOM1"       
## [257] "RP11-3K24.1"    "TCN1"           "MYLK3"          "RP11-164H5.1"  
## [261] "RP11-49O14.3"   "HK2P1"          "AC138517.1"     "RP11-112L18.1" 
## [265] "ATP5A1P3"       "ANKRD36C"       "CTD-2547H18.1"  "PLEKHD1"       
## [269] "RP11-359B20.1"  "RPL7L1P2"       "PYCR1"          "LBX2"          
## [273] "AC005077.14"    "RP11-131K5.1"   "DQX1"           "CTB-11I22.2"   
## [277] "AC110619.1"     "LAP3P1"         "AC144450.1"     "GS1-122H1.1"   
## [281] "RN7SKP239"      "ADAMDEC1"       "RP11-195B21.3"  "RP11-27M24.2"  
## [285] "AP001468.1"     "CXCL2"          "CCDC144NL"      "RP11-100J16.4" 
## [289] "RP11-381G8.1"   "AC097468.4"     "PRKXP1"         "CTHRC1"        
## [293] "RP11-486O13.4"  "RP11-353J17.3"  "ITPKB-IT1"      "RP11-332H18.3" 
## [297] "RP5-1041C10.3"  "CPE"            "ABO"            "BACE2-IT1"     
## [301] "RP11-554D13.1"  "PSORS1C1"       "RP3-342P20.2"   "JPH2"          
## [305] "AF131215.4"     "PLAT"           "MSLN"           "NDUFB8P2"      
## [309] "GPR37"          "RP11-534P19.1"  "AC017060.1"     "AC009061.1"    
## [313] "RPS16P5"        "CTD-2201E18.5"  "RP11-555K12.2"  "CHAD"          
## [317] "BHLHA15"        "AC114737.3"     "C1orf64"        "AC091171.1"    
## [321] "STEAP3-AS1"     "PDCL3P6"        "AC015987.1"     "RP13-870H17.3" 
## [325] "CTD-2547L24.4"  "RP11-680G24.4"  "FTLP14"         "CTA-331F8.1"   
## [329] "RP11-317F20.2"  "RP1-168P16.1"   "LCN2"           "RP11-99A1.2"   
## [333] "BTNL9"          "RP11-214O1.3"   "XBP1P1"         "RP11-21A7A.3"  
## [337] "RP11-982M15.8"  "RTEL1-TNFRSF6B" "RP11-241J12.3"  "IL1R2"         
## [341] "CTD-2555A7.2"   "HCG20"          "RP11-327F22.6"  "RP11-34P13.13" 
## [345] "CYP1B1-AS1"     "RP11-318K15.2"  "AC026806.2"     "RP11-1396O13.2"
## [349] "RP11-449P15.1"  "NKX3-1"         "HSD11B2"        "KLF7-IT1"      
## [353] "RP11-206L10.3"  "ALDH1L2"        "RP11-68I3.11"   "AC139426.2"    
## [357] "RP11-356M20.3"  "PDPK2"          "RP11-384C4.6"   "CTD-3222D19.5" 
## [361] "GRM8"           "RP11-158M2.5"   "LINC01002"      "OMP"           
## [365] "RP11-553A21.3"  "RP11-443F16.1"  "AP000347.4"     "RP11-231C14.4" 
## [369] "CTB-181H17.1"   "AC000089.3"     "CTD-2619J13.8"  "RP11-453A12.1" 
## [373] "RP11-422N16.3"  "RP11-458F8.4"   "HMSD"           "CTB-131B5.2"   
## [377] "RP11-305L7.5"   "GJA6P"          "SYT8"           "FOXA3"         
## [381] "AC010525.7"     "RAB43"          "RP1-308E4.1"    "LINC00930"     
## [385] "FUT6"           "RP11-404P21.5"  "RP11-392E22.12" "RABGAP1L-IT1"  
## [389] "SLC25A47P1"     "RP11-281P23.2"  "NEK6"           "RP11-1082L8.1" 
## [393] "AC019117.2"     "CTB-11I22.1"    "RP11-392E22.5"  "RP11-305O4.2"  
## [397] "RP11-982M15.6"  "AC138035.2"     "AK4P4"          "RP1-313L4.3"   
## [401] "RN7SL23P"       "RP11-365D23.4"  "ARMC12"         "ATP10B"        
## [405] "SLC16A14"       "RP11-16E23.3"   "ANKRD18A.1"     "TFCP2L1"       
## [409] "CDC42EP5"       "RP11-163G10.2"  "PKHD1L1"        "PPIAP10"       
## [413] "CTC-251D13.1"   "SEMA3B"         "RP1-5O6.4"      "ANO1"          
## [417] "FBXO36-IT1"     "RPL19P12"       "AC005831.1"

GSEA, comparison with COPD signature

Gene set enrichment analysis was conducted using genes associated with COPD status from Steiling et al, 2013. The preranked version of GSEA was performed on normalized counts generated from DESeq2. The rank was generated in ascending order of log2 fold change values outputted from DESeq2.

Model used: ~Smoking status + Age + TIN + COPD status

Upregulated Genes in COPD

54 Genes associated with increase in COPD status were used for GSEA.

GSEA <- c(0.685,2.17,0.0,0.0, 0.0)
GSEA <- as.data.frame(as.matrix(GSEA))
rownames(GSEA) <- c("Enrichment Score",
                    "Normalized Enrichment Score",
                    "Nominal p-value",
                    "FDR q-value",
                    "FWER q-value")
colnames(GSEA) <- c("Upregulated in current smokers")

GSEA %>%
  knitr::kable(
    format = "html", align = rep("c", ncol(GSEA) + 1),
    row.names = TRUE
  ) %>%
  kableExtra::kable_styling() %>%
  kableExtra::scroll_box(height = "200px")

	Upregulated in current smokers
Enrichment Score	0.685
Normalized Enrichment Score	2.170
Nominal p-value	0.000
FDR q-value	0.000
FWER q-value	0.000

gsea_details1 <- read.csv("/restricted/projectnb/camplab/home/ykoga07/DECAMP/Novartis/Analysis/1stPass/GSEA_Increase_in_COPD_PreRank_Bronch.csv", row.names = 1)
colnames(gsea_details1) <- gsub("\\.", "_", colnames(gsea_details1)) 

gsea_details1 <- merge(upBM, gsea_details1, by.x = "ensembl_gene_id", by.y = "ENSEMBL_GENEID")
gsea_details1 <- gsea_details1[order(gsea_details1$RANK_IN_GENE_LIST),]

gsea_details1 %>%
  knitr::kable(
    format = "html", align = rep("c", ncol(gsea_details1) + 1),
    row.names = FALSE
  ) %>%
  kableExtra::kable_styling() %>%
  kableExtra::scroll_box(height = "300px")

ensembl_gene_id	hgnc_symbol	RANK_IN_GENE_LIST	RANK_METRIC_SCORE	RUNNING_ES	CORE_ENRICHMENT
ENSG00000111700	SLCO1B3	301	0.788	0.0416	Yes
ENSG00000105388	CEACAM5	369	0.746	0.0871	Yes
ENSG00000134827	TCN1	596	0.646	0.1218	Yes
ENSG00000155850	SLC26A2	672	0.621	0.1592	Yes
ENSG00000073756	PTGS2	936	0.553	0.1870	Yes
ENSG00000133962	CATSPERB	960	0.548	0.2211	Yes
ENSG00000140297	GCNT3	1089	0.531	0.2512	Yes
ENSG00000137440	FGFBP1	1132	0.525	0.2834	Yes
ENSG00000128683	GAD1	1197	0.516	0.3143	Yes
ENSG00000090376	IRAK3	1228	0.510	0.3459	Yes
ENSG00000180438	TPRXL	1312	0.498	0.3751	Yes
ENSG00000169116	PARM1	1343	0.494	0.4056	Yes
ENSG00000115590	IL1R2	1475	0.476	0.4322	Yes
ENSG00000118322	ATP10B	1505	0.473	0.4614	Yes
ENSG00000156535	CD109	1550	0.468	0.4899	Yes
ENSG00000171124	FUT3	1597	0.462	0.5179	Yes
ENSG00000188761	BCL2L15	1729	0.448	0.5427	Yes
ENSG00000114638	UPK1B	1838	0.438	0.5675	Yes
ENSG00000113657	DPYSL3	2472	0.391	0.5748	Yes
ENSG00000176907	TCIM	2502	0.389	0.5987	Yes
ENSG00000144452	ABCA12	2769	0.374	0.6150	Yes
ENSG00000148346	LCN2	2818	0.371	0.6372	Yes
ENSG00000116711	PLA2G4A	2933	0.365	0.6572	Yes
ENSG00000145113	MUC4	3391	0.343	0.6663	Yes
ENSG00000173702	MUC13	3485	0.339	0.6853	Yes
ENSG00000029153	ARNTL2	4272	0.304	0.6828	No
ENSG00000256870	SLC5A8	4939	0.281	0.6822	No
ENSG00000135976	ANKRD36	6183	0.239	0.6631	No
ENSG00000102359	SRPX2	6599	0.227	0.6660	No
ENSG00000244734	HBB	7359	0.207	0.6581	No
ENSG00000108242	CYP2C18	7378	0.207	0.6707	No
ENSG00000147697	GSDMC	9417	0.156	0.6243	No
ENSG00000136231	IGF2BP3	11562	0.116	0.5724	No
ENSG00000156689	GLYATL2	11654	0.115	0.5772	No
ENSG00000148965	SAA4	14316	0.074	0.5083	No
ENSG00000173432	SAA1	14899	0.066	0.4963	No
ENSG00000168412	MTNR1A	16245	0.050	0.4623	No
ENSG00000091137	SLC26A4	17027	0.041	0.4433	No
ENSG00000094755	GABRP	17043	0.040	0.4454	No
ENSG00000243649	CFB	17228	0.038	0.4428	No
ENSG00000134339	SAA2	19266	0.016	0.3875	No
ENSG00000242515	UGT1A10	19307	0.016	0.3874	No
ENSG00000166920	C15orf48	19523	0.014	0.3823	No
ENSG00000131203	IDO1	23639	-0.030	0.2704	No
ENSG00000261857	MIA	24366	-0.038	0.2528	No
ENSG00000197641	SERPINB13	25959	-0.058	0.2125	No
ENSG00000163606	CD200R1	26407	-0.064	0.2042	No
ENSG00000204616	TRIM31	27454	-0.080	0.1803	No
ENSG00000138166	DUSP5	29914	-0.130	0.1206	No
ENSG00000134762	DSC3	30044	-0.133	0.1254	No
ENSG00000123358	NR4A1	30792	-0.154	0.1146	No
ENSG00000170345	FOS	31541	-0.179	0.1052	No
ENSG00000041982	TNC	31618	-0.182	0.1147	No
ENSG00000153802	TMPRSS11D	32061	-0.200	0.1152	No

Downregulated Genes in COPD

44 Genes associated with decrease in COPD status were used for GSEA.

GSEA <- c(0.612,2.11,0.0,0.0, 0.0)
GSEA <- as.data.frame(as.matrix(GSEA))
rownames(GSEA) <- c("Enrichment Score",
                    "Normalized Enrichment Score",
                    "Nominal p-value",
                    "FDR q-value",
                    "FWER q-value")
colnames(GSEA) <- c("Downregulated in current smokers")

GSEA %>%
  knitr::kable(
    format = "html", align = rep("c", ncol(GSEA) + 1),
    row.names = TRUE
  ) %>%
  kableExtra::kable_styling() %>%
  kableExtra::scroll_box(height = "200px")

	Downregulated in current smokers
Enrichment Score	0.612
Normalized Enrichment Score	2.110
Nominal p-value	0.000
FDR q-value	0.000
FWER q-value	0.000

gsea_details2 <- read.csv("/restricted/projectnb/camplab/home/ykoga07/DECAMP/Novartis/Analysis/1stPass/GSEA_Decrease_in_COPD_PreRank_Bronch.csv", row.names = 1)
colnames(gsea_details2) <- gsub("\\.", "_", colnames(gsea_details2)) 

gsea_details2 <- merge(downBM, gsea_details2, by.x = "ensembl_gene_id", by.y = "ENSEMBL_GENEID")
gsea_details2 <- gsea_details2[order(gsea_details2$RANK_IN_GENE_LIST),]

gsea_details2 %>%
  knitr::kable(
    format = "html", align = rep("c", ncol(gsea_details2) + 1),
    row.names = FALSE
  ) %>%
  kableExtra::kable_styling() %>%
  kableExtra::scroll_box(height = "300px")

ensembl_gene_id	hgnc_symbol	RANK_IN_GENE_LIST	RANK_METRIC_SCORE	RUNNING_ES	CORE_ENRICHMENT
ENSG00000039537	C6	2751	0.375	-0.0328	No
ENSG00000177300	CLDN22	6204	0.239	-0.1007	No
ENSG00000185689	C6orf201	6451	0.232	-0.0807	No
ENSG00000166396	SERPINB7	7644	0.200	-0.0906	No
ENSG00000106772	PRUNE2	9489	0.155	-0.1237	No
ENSG00000113448	PDE4D	14795	0.067	-0.2626	No
ENSG00000164265	SCGB3A2	17090	0.040	-0.3214	No
ENSG00000170381	SEMA3E	19154	0.017	-0.3764	No
ENSG00000173376	NDNF	20197	0.007	-0.4044	No
ENSG00000048540	LMO3	20319	0.005	-0.4071	No
ENSG00000170509	HSD17B13	20415	0.004	-0.4093	No
ENSG00000154864	PIEZO2	21873	-0.011	-0.4483	No
ENSG00000186417	GLDN	24474	-0.040	-0.5156	No
ENSG00000173988	LRRC63	26469	-0.065	-0.5632	No
ENSG00000133124	IRS4	27358	-0.078	-0.5786	No
ENSG00000145147	SLIT2	28551	-0.099	-0.6001	Yes
ENSG00000167315	ACAA2	28815	-0.105	-0.5953	Yes
ENSG00000012223	LTF	29206	-0.113	-0.5931	Yes
ENSG00000069122	ADGRF5	29524	-0.121	-0.5880	Yes
ENSG00000149201	CCDC81	29703	-0.125	-0.5785	Yes
ENSG00000147231	RADX	30041	-0.133	-0.5725	Yes
ENSG00000136205	TNS3	30319	-0.141	-0.5640	Yes
ENSG00000198721	ECI2	30579	-0.148	-0.5541	Yes
ENSG00000147570	DNAJC5B	31533	-0.179	-0.5403	Yes
ENSG00000161298	ZNF382	31621	-0.182	-0.5217	Yes
ENSG00000134775	FHOD3	32120	-0.203	-0.5121	Yes
ENSG00000122420	PTGFR	32302	-0.211	-0.4927	Yes
ENSG00000156076	WIF1	32466	-0.220	-0.4719	Yes
ENSG00000081479	LRP2	32750	-0.234	-0.4527	Yes
ENSG00000156284	CLDN8	32791	-0.237	-0.4265	Yes
ENSG00000103647	CORO2B	32820	-0.238	-0.3998	Yes
ENSG00000134443	GRP	32921	-0.243	-0.3746	Yes
ENSG00000197584	KCNMB2	33108	-0.254	-0.3505	Yes
ENSG00000163285	GABRG1	33335	-0.267	-0.3259	Yes
ENSG00000166148	AVPR1A	33537	-0.282	-0.2990	Yes
ENSG00000206538	VGLL3	33600	-0.286	-0.2677	Yes
ENSG00000127990	SGCE	34198	-0.332	-0.2459	Yes
ENSG00000038295	TLL1	34371	-0.349	-0.2104	Yes
ENSG00000242265	PEG10	35044	-0.432	-0.1792	Yes
ENSG00000079819	EPB41L2	35057	-0.434	-0.1295	Yes
ENSG00000113389	NPR3	35084	-0.436	-0.0799	Yes
ENSG00000096006	CRISP3	35302	-0.469	-0.0318	Yes
ENSG00000111341	MGP	35448	-0.497	0.0215	Yes

EnrichR, upregulated genes

## Uploading data to Enrichr... Done.
##   Querying GO_Molecular_Function_2015... Done.
##   Querying GO_Cellular_Component_2015... Done.
##   Querying GO_Biological_Process_2015... Done.
## Parsing results... Done.

GO_Biological_Process_2015

go_biological %>%
  knitr::kable(
    format = "html", align = rep("c", ncol(go_biological) + 1),
    row.names = TRUE
  ) %>%
  kableExtra::kable_styling() %>%
  kableExtra::scroll_box(height = "300px")

	Term	Overlap	P.value	Adjusted.P.value	Old.P.value	Old.Adjusted.P.value	Odds.Ratio	Combined.Score	Genes
1	positive regulation of phosphatidylinositol 3-kinase signaling (GO:0014068)	5/51	0.0041953	1	0	0	4.6796762	25.6156174	NTRK2;CSF3;ADORA3;WNT16;NKX3-1
2	O-glycan processing (GO:0016266)	5/56	0.0062667	1	0	0	4.2618479	21.6182668	MUC1;B3GNT6;MUC3A;MUC5AC;MUC6
3	regulation of phosphatidylinositol 3-kinase signaling (GO:0014066)	5/66	0.0123812	1	0	0	3.6161134	15.8804244	NTRK2;CSF3;ADORA3;WNT16;NKX3-1
4	glucocorticoid biosynthetic process (GO:0006704)	2/10	0.0176287	1	0	0	9.5465394	38.5510798	HSD11B2;CYP17A1
5	positive regulation of steroid hormone secretion (GO:2000833)	2/11	0.0212509	1	0	0	8.6786722	33.4246616	C1QTNF1;NKX3-1
6	digestive system process (GO:0022600)	4/51	0.0218884	1	0	0	3.7437409	14.3078149	CHRM1;TFF1;ADRA2A;MUC6
7	regulation of smooth muscle contraction (GO:0006940)	4/51	0.0218884	1	0	0	3.7437409	14.3078149	EDN2;TNNI3;PTGS2;ADRA2A
8	negative regulation of hydrogen peroxide-induced cell death (GO:1903206)	2/12	0.0251521	1	0	0	7.9554495	29.2984249	GPR37;PYCR1
9	negative regulation of insulin secretion (GO:0046676)	3/31	0.0265911	1	0	0	4.6192932	16.7549945	BMP8A;ADRA2A;STXBP5L
10	negative regulation of response to reactive oxygen species (GO:1901032)	2/13	0.0293193	1	0	0	7.3434918	25.9189276	GPR37;PYCR1
11	maintenance of gastrointestinal epithelium (GO:0030277)	2/13	0.0293193	1	0	0	7.3434918	25.9189276	TFF1;MUC6
12	regulation of hydrogen peroxide-induced cell death (GO:1903205)	2/13	0.0293193	1	0	0	7.3434918	25.9189276	GPR37;PYCR1
13	lipoxygenase pathway (GO:0019372)	2/13	0.0293193	1	0	0	7.3434918	25.9189276	PTGS2;ALOX15B
14	positive regulation of cell fate commitment (GO:0010455)	2/13	0.0293193	1	0	0	7.3434918	25.9189276	PAX6;SPDEF
15	positive regulation of transforming growth factor beta production (GO:0071636)	2/13	0.0293193	1	0	0	7.3434918	25.9189276	PTGS2;THBS1
16	protein O-linked glycosylation (GO:0006493)	5/83	0.0302483	1	0	0	2.8754637	10.0592761	MUC1;B3GNT6;MUC3A;MUC5AC;MUC6
17	female pregnancy (GO:0007565)	5/85	0.0330527	1	0	0	2.8078057	9.5736393	HSD11B2;MUC1;TFCP2L1;ADRA2A;PTHLH
18	prostaglandin biosynthetic process (GO:0001516)	2/14	0.0337395	1	0	0	6.8189567	23.1100332	EDN2;PTGS2
19	negative regulation of smooth muscle contraction (GO:0045986)	2/14	0.0337395	1	0	0	6.8189567	23.1100332	PTGS2;ADRA2A
20	cartilage development involved in endochondral bone morphogenesis (GO:0060351)	2/14	0.0337395	1	0	0	6.8189567	23.1100332	COMP;THBS1
21	prostanoid biosynthetic process (GO:0046457)	2/14	0.0337395	1	0	0	6.8189567	23.1100332	EDN2;PTGS2
22	ossification (GO:0001503)	6/116	0.0353823	1	0	0	2.4689326	8.2500448	SLC26A2;AHSG;BMP8A;STC1;PTHLH;CTHRC1
23	negative regulation of peptide hormone secretion (GO:0090278)	3/35	0.0364310	1	0	0	4.0913740	13.5520062	BMP8A;ADRA2A;STXBP5L
24	ovulation (GO:0030728)	2/15	0.0384004	1	0	0	6.3643596	20.7458237	PTGS2;CYP17A1
25	positive regulation of macrophage derived foam cell differentiation (GO:0010744)	2/15	0.0384004	1	0	0	6.3643596	20.7458237	APOB;ALOX15B
26	negative regulation of interleukin-12 production (GO:0032695)	2/15	0.0384004	1	0	0	6.3643596	20.7458237	IRAK3;THBS1
27	negative regulation of peptide secretion (GO:0002792)	3/36	0.0391442	1	0	0	3.9777247	12.8898316	BMP8A;ADRA2A;STXBP5L
28	epithelial cell maturation (GO:0002070)	2/16	0.0432900	1	0	0	5.9665871	18.7340875	SIX3;TFCP2L1
29	negative regulation of anoikis (GO:2000811)	2/16	0.0432900	1	0	0	5.9665871	18.7340875	NTRK2;CEACAM5
30	glucocorticoid metabolic process (GO:0008211)	2/16	0.0432900	1	0	0	5.9665871	18.7340875	HSD11B2;CYP17A1
31	negative regulation of calcium ion transport (GO:0051926)	3/38	0.0448688	1	0	0	3.7683708	11.6970666	STC1;PTGS2;ADRA2A
32	regulation of steroid hormone secretion (GO:2000831)	2/17	0.0483968	1	0	0	5.6156114	17.0058776	C1QTNF1;NKX3-1
33	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	2/17	0.0483968	1	0	0	5.6156114	17.0058776	SULT1C2;SLC26A2
34	3’-phosphoadenosine 5’-phosphosulfate metabolic process (GO:0050427)	2/17	0.0483968	1	0	0	5.6156114	17.0058776	SULT1C2;SLC26A2
35	epithelial structure maintenance (GO:0010669)	2/17	0.0483968	1	0	0	5.6156114	17.0058776	TFF1;MUC6
36	decidualization (GO:0046697)	2/18	0.0537095	1	0	0	5.3036330	15.5086983	STC1;PTGS2
37	inner ear receptor stereocilium organization (GO:0060122)	2/18	0.0537095	1	0	0	5.3036330	15.5086983	PCDH15;CTHRC1
38	positive regulation of synaptic transmission, glutamatergic (GO:0051968)	2/18	0.0537095	1	0	0	5.3036330	15.5086983	NTRK2;PTGS2
39	regulation of cAMP biosynthetic process (GO:0030817)	5/98	0.0551609	1	0	0	2.4353417	7.0564042	NTRK2;ADORA3;GRM8;ADRA2A;PTHLH
40	positive regulation of lipid transport (GO:0032370)	3/44	0.0643482	1	0	0	3.2545021	8.9285531	C1QTNF1;LIPG;NKX3-1
41	glandular epithelial cell differentiation (GO:0002067)	2/20	0.0649099	1	0	0	4.7732697	13.0537266	PAX6;SPDEF
42	regulation of anoikis (GO:2000209)	2/20	0.0649099	1	0	0	4.7732697	13.0537266	NTRK2;CEACAM5
43	negative regulation of muscle contraction (GO:0045932)	2/20	0.0649099	1	0	0	4.7732697	13.0537266	PTGS2;ADRA2A
44	hydrogen peroxide catabolic process (GO:0042744)	2/20	0.0649099	1	0	0	4.7732697	13.0537266	TPO;PXDN
45	cellular response to interleukin-1 (GO:0071347)	3/45	0.0679171	1	0	0	3.1821798	8.5583702	IRAK3;MYLK3;NKX3-1
46	response to vitamin D (GO:0033280)	2/21	0.0707769	1	0	0	4.5459711	12.0387430	STC1;PTGS2
47	cartilage development (GO:0051216)	4/75	0.0724979	1	0	0	2.5457438	6.6805349	COMP;ZBTB16;BMP8A;THBS1
48	regulation of synaptic transmission, glutamatergic (GO:0051966)	3/47	0.0753177	1	0	0	3.0467679	7.8790655	NTRK2;GRM8;PTGS2
49	regulation of transforming growth factor beta production (GO:0071634)	2/22	0.0768087	1	0	0	4.3393361	11.1366327	PTGS2;THBS1
50	carbohydrate homeostasis (GO:0033500)	6/143	0.0806388	1	0	0	2.0027705	5.0425256	HKDC1;PAX6;BHLHA15;ADRA2A;FOXA3;STXBP5L
51	glucose homeostasis (GO:0042593)	6/143	0.0806388	1	0	0	2.0027705	5.0425256	HKDC1;PAX6;BHLHA15;ADRA2A;FOXA3;STXBP5L
52	positive regulation of leukocyte migration (GO:0002687)	4/78	0.0811389	1	0	0	2.4478306	6.1479535	CCL24;EDN2;ADORA3;THBS1
53	regulation of response to reactive oxygen species (GO:1901031)	2/23	0.0829959	1	0	0	4.1506693	10.3308677	GPR37;PYCR1
54	protein-lipid complex remodeling (GO:0034368)	2/23	0.0829959	1	0	0	4.1506693	10.3308677	LIPG;APOB
55	plasma lipoprotein particle remodeling (GO:0034369)	2/23	0.0829959	1	0	0	4.1506693	10.3308677	LIPG;APOB
56	endocrine process (GO:0050886)	2/23	0.0829959	1	0	0	4.1506693	10.3308677	HSD11B2;EDN2
57	macromolecular complex remodeling (GO:0034367)	2/23	0.0829959	1	0	0	4.1506693	10.3308677	LIPG;APOB
58	regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)	2/23	0.0829959	1	0	0	4.1506693	10.3308677	HSD11B2;EDN2
59	prostaglandin metabolic process (GO:0006693)	2/23	0.0829959	1	0	0	4.1506693	10.3308677	EDN2;PTGS2
60	prostanoid metabolic process (GO:0006692)	2/23	0.0829959	1	0	0	4.1506693	10.3308677	EDN2;PTGS2
61	positive regulation of blood vessel endothelial cell migration (GO:0043536)	2/23	0.0829959	1	0	0	4.1506693	10.3308677	PTGS2;THBS1
62	regulation of systemic arterial blood pressure by hormone (GO:0001990)	2/23	0.0829959	1	0	0	4.1506693	10.3308677	HSD11B2;EDN2
63	regulation of cAMP metabolic process (GO:0030814)	5/113	0.0891193	1	0	0	2.1120662	5.1065095	NTRK2;ADORA3;GRM8;ADRA2A;PTHLH
64	unsaturated fatty acid biosynthetic process (GO:0006636)	3/51	0.0911233	1	0	0	2.8078057	6.7262158	EDN2;PTGS2;ALOX15B
65	regulation of muscle contraction (GO:0006937)	5/114	0.0916980	1	0	0	2.0935393	5.0019998	EDN2;STC1;TNNI3;PTGS2;ADRA2A
66	regulation of vasoconstriction (GO:0019229)	3/52	0.0952738	1	0	0	2.7538094	6.4742078	EDN2;PTGS2;ADRA2A
67	columnar/cuboidal epithelial cell development (GO:0002066)	2/25	0.0958000	1	0	0	3.8186158	8.9565341	PAX6;SPDEF
68	positive regulation of smooth muscle contraction (GO:0045987)	2/25	0.0958000	1	0	0	3.8186158	8.9565341	EDN2;PTGS2
69	response to testosterone (GO:0033574)	2/25	0.0958000	1	0	0	3.8186158	8.9565341	THBS1;NKX3-1
70	regulation of lipid transport (GO:0032368)	4/83	0.0966088	1	0	0	2.3003709	5.3761630	C1QTNF1;LIPG;THBS1;NKX3-1
71	regulation of cyclic nucleotide biosynthetic process (GO:0030802)	5/116	0.0969693	1	0	0	2.0574438	4.8007583	NTRK2;ADORA3;GRM8;ADRA2A;PTHLH
72	keratinocyte differentiation (GO:0030216)	3/54	0.1038009	1	0	0	2.6518165	6.0071090	CDSN;PAX6;WNT16
73	regulation of purine nucleotide biosynthetic process (GO:1900371)	5/119	0.1051573	1	0	0	2.0055755	4.5171533	NTRK2;ADORA3;GRM8;ADRA2A;PTHLH
74	regulation of nucleotide biosynthetic process (GO:0030808)	5/119	0.1051573	1	0	0	2.0055755	4.5171533	NTRK2;ADORA3;GRM8;ADRA2A;PTHLH
75	multi-multicellular organism process (GO:0044706)	5/121	0.1107996	1	0	0	1.9724255	4.3394001	HSD11B2;MUC1;TFCP2L1;ADRA2A;PTHLH
76	adenylate cyclase-modulating G-protein coupled receptor signaling pathway (GO:0007188)	5/122	0.1136747	1	0	0	1.9562581	4.2537152	GPR37;ADM2;GRM8;ADRA2A;PTHLH
77	negative regulation of oxidative stress-induced cell death (GO:1903202)	2/28	0.1159532	1	0	0	3.4094783	7.3459547	GPR37;PYCR1
78	regulation of neuroblast proliferation (GO:1902692)	2/28	0.1159532	1	0	0	3.4094783	7.3459547	SIX3;PAX6
79	regulation of macrophage derived foam cell differentiation (GO:0010743)	2/28	0.1159532	1	0	0	3.4094783	7.3459547	APOB;ALOX15B
80	negative regulation of hormone secretion (GO:0046888)	3/57	0.1171287	1	0	0	2.5122472	5.3874682	BMP8A;ADRA2A;STXBP5L
81	positive regulation of actin filament polymerization (GO:0030838)	3/57	0.1171287	1	0	0	2.5122472	5.3874682	CCL24;CSF3;CDC42EP5
82	negative regulation of response to oxidative stress (GO:1902883)	2/29	0.1228915	1	0	0	3.2919101	6.9013369	GPR37;PYCR1
83	negative regulation of cellular response to oxidative stress (GO:1900408)	2/29	0.1228915	1	0	0	3.2919101	6.9013369	GPR37;PYCR1
84	regulation of systemic arterial blood pressure (GO:0003073)	2/29	0.1228915	1	0	0	3.2919101	6.9013369	HSD11B2;EDN2
85	pituitary gland development (GO:0021983)	2/29	0.1228915	1	0	0	3.2919101	6.9013369	SIX3;PAX6
86	lens development in camera-type eye (GO:0002088)	2/30	0.1299275	1	0	0	3.1821798	6.4941249	SIX3;PAX6
87	regulation of membrane lipid distribution (GO:0097035)	2/30	0.1299275	1	0	0	3.1821798	6.4941249	ATP10B;ANO7
88	regulation of cell fate commitment (GO:0010453)	2/30	0.1299275	1	0	0	3.1821798	6.4941249	PAX6;SPDEF
89	negative regulation of ion transport (GO:0043271)	4/94	0.1349839	1	0	0	2.0311786	4.0676380	STC1;PTGS2;THBS1;ADRA2A
90	negative regulation of endothelial cell migration (GO:0010596)	2/31	0.1370541	1	0	0	3.0795288	6.1201917	STC1;THBS1
91	positive regulation of muscle contraction (GO:0045933)	2/31	0.1370541	1	0	0	3.0795288	6.1201917	EDN2;PTGS2
92	plasma lipoprotein particle organization (GO:0071827)	2/31	0.1370541	1	0	0	3.0795288	6.1201917	LIPG;APOB
93	positive regulation of response to wounding (GO:1903036)	5/130	0.1379232	1	0	0	1.8358730	3.6369716	CCL24;ADORA3;PTGS2;THBS1;ADRA2A
94	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway (GO:0007193)	3/62	0.1406464	1	0	0	2.3096466	4.5303865	GPR37;GRM8;ADRA2A
95	regulation of adenylate cyclase activity (GO:0045761)	3/62	0.1406464	1	0	0	2.3096466	4.5303865	NTRK2;ADORA3;ADRA2A
96	eye photoreceptor cell development (GO:0042462)	2/32	0.1442646	1	0	0	2.9832936	5.7759738	NTRK2;PAX6
97	activation of adenylate cyclase activity (GO:0007190)	2/32	0.1442646	1	0	0	2.9832936	5.7759738	NTRK2;ADORA3
98	negative regulation of cytokine-mediated signaling pathway (GO:0001960)	2/32	0.1442646	1	0	0	2.9832936	5.7759738	PXDN;IRAK3
99	negative regulation of cAMP biosynthetic process (GO:0030818)	2/32	0.1442646	1	0	0	2.9832936	5.7759738	GRM8;ADRA2A
100	response to purine-containing compound (GO:0014074)	5/132	0.1443166	1	0	0	1.8080567	3.4999387	STC1;PLAT;SLC6A1;PTGS2;CYP17A1
101	regulation of cyclic nucleotide metabolic process (GO:0030799)	5/133	0.1475605	1	0	0	1.7944623	3.4337340	NTRK2;ADORA3;GRM8;ADRA2A;PTHLH
102	negative regulation of cyclic nucleotide biosynthetic process (GO:0030803)	2/33	0.1515521	1	0	0	2.8928907	5.4583800	GRM8;ADRA2A
103	hydrogen peroxide metabolic process (GO:0042743)	2/33	0.1515521	1	0	0	2.8928907	5.4583800	TPO;PXDN
104	protein-lipid complex subunit organization (GO:0071825)	2/33	0.1515521	1	0	0	2.8928907	5.4583800	LIPG;APOB
105	positive regulation of cAMP biosynthetic process (GO:0030819)	3/65	0.1554543	1	0	0	2.2030475	4.1007610	NTRK2;ADORA3;PTHLH
106	bone trabecula formation (GO:0060346)	1/8	0.1558373	1	0	0	5.9665871	11.0915436	FBN2
107	negative regulation of calcium ion-dependent exocytosis (GO:0045955)	1/8	0.1558373	1	0	0	5.9665871	11.0915436	ADRA2A
108	short-term memory (GO:0007614)	1/8	0.1558373	1	0	0	5.9665871	11.0915436	CUX2
109	energy homeostasis (GO:0097009)	1/8	0.1558373	1	0	0	5.9665871	11.0915436	EDN2
110	positive regulation of heat generation (GO:0031652)	1/8	0.1558373	1	0	0	5.9665871	11.0915436	PTGS2
111	nucleoside diphosphate catabolic process (GO:0009134)	1/8	0.1558373	1	0	0	5.9665871	11.0915436	ENTPD2
112	positive regulation of fibroblast migration (GO:0010763)	1/8	0.1558373	1	0	0	5.9665871	11.0915436	THBS1
113	regulation of dendritic cell antigen processing and presentation (GO:0002604)	1/8	0.1558373	1	0	0	5.9665871	11.0915436	THBS1
114	proline biosynthetic process (GO:0006561)	1/8	0.1558373	1	0	0	5.9665871	11.0915436	PYCR1
115	regulation of fever generation (GO:0031620)	1/8	0.1558373	1	0	0	5.9665871	11.0915436	PTGS2
116	regulation of sarcomere organization (GO:0060297)	1/8	0.1558373	1	0	0	5.9665871	11.0915436	MYLK3
117	C4-dicarboxylate transport (GO:0015740)	1/8	0.1558373	1	0	0	5.9665871	11.0915436	SLC13A5
118	cornea development in camera-type eye (GO:0061303)	1/8	0.1558373	1	0	0	5.9665871	11.0915436	PAX6
119	very-low-density lipoprotein particle assembly (GO:0034379)	1/8	0.1558373	1	0	0	5.9665871	11.0915436	APOB
120	sequestering of extracellular ligand from receptor (GO:0035581)	1/8	0.1558373	1	0	0	5.9665871	11.0915436	FBN2
121	artery smooth muscle contraction (GO:0014824)	1/8	0.1558373	1	0	0	5.9665871	11.0915436	EDN2
122	response to methylmercury (GO:0051597)	1/8	0.1558373	1	0	0	5.9665871	11.0915436	CYP17A1
123	regulation of transforming growth factor beta1 production (GO:0032908)	1/8	0.1558373	1	0	0	5.9665871	11.0915436	THBS1
124	neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)	1/8	0.1558373	1	0	0	5.9665871	11.0915436	TNNI3
125	positive regulation of vesicle fusion (GO:0031340)	1/8	0.1558373	1	0	0	5.9665871	11.0915436	DOC2B
126	skin morphogenesis (GO:0043589)	1/8	0.1558373	1	0	0	5.9665871	11.0915436	CDSN
127	chondrocyte proliferation (GO:0035988)	1/8	0.1558373	1	0	0	5.9665871	11.0915436	STC1
128	positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)	1/8	0.1558373	1	0	0	5.9665871	11.0915436	JPH2
129	negative regulation of fatty acid transport (GO:2000192)	1/8	0.1558373	1	0	0	5.9665871	11.0915436	THBS1
130	righting reflex (GO:0060013)	1/8	0.1558373	1	0	0	5.9665871	11.0915436	PCDH15
131	positive regulation of chemokine secretion (GO:0090197)	1/8	0.1558373	1	0	0	5.9665871	11.0915436	ALOX15B
132	receptor recycling (GO:0001881)	1/8	0.1558373	1	0	0	5.9665871	11.0915436	REP15
133	cellular response to ATP (GO:0071318)	1/8	0.1558373	1	0	0	5.9665871	11.0915436	PTGS2
134	histamine secretion (GO:0001821)	1/8	0.1558373	1	0	0	5.9665871	11.0915436	ADORA3
135	intestinal epithelial cell development (GO:0060576)	1/8	0.1558373	1	0	0	5.9665871	11.0915436	SPDEF
136	positive regulation of dendritic spine morphogenesis (GO:0061003)	1/8	0.1558373	1	0	0	5.9665871	11.0915436	CUX2
137	negative regulation of norepinephrine secretion (GO:0010700)	1/8	0.1558373	1	0	0	5.9665871	11.0915436	ADRA2A
138	low-density lipoprotein particle clearance (GO:0034383)	1/8	0.1558373	1	0	0	5.9665871	11.0915436	APOB
139	negative regulation of synaptic transmission, GABAergic (GO:0032229)	1/8	0.1558373	1	0	0	5.9665871	11.0915436	SLC6A1
140	photoreceptor cell development (GO:0042461)	2/34	0.1589105	1	0	0	2.8078057	5.1647173	NTRK2;PAX6
141	regulation of calcium ion-dependent exocytosis (GO:0017158)	2/34	0.1589105	1	0	0	2.8078057	5.1647173	DOC2B;ADRA2A
142	positive regulation of angiogenesis (GO:0045766)	4/101	0.1621454	1	0	0	1.8904038	3.4391397	CCL24;ADM2;PTGS2;THBS1
143	negative regulation of purine nucleotide biosynthetic process (GO:1900372)	2/35	0.1663335	1	0	0	2.7275827	4.8926297	GRM8;ADRA2A
144	nucleoside bisphosphate metabolic process (GO:0033865)	2/35	0.1663335	1	0	0	2.7275827	4.8926297	SULT1C2;SLC26A2
145	regulation of endocrine process (GO:0044060)	2/35	0.1663335	1	0	0	2.7275827	4.8926297	C1QTNF1;NKX3-1
146	ribonucleoside bisphosphate metabolic process (GO:0033875)	2/35	0.1663335	1	0	0	2.7275827	4.8926297	SULT1C2;SLC26A2
147	purine nucleoside bisphosphate metabolic process (GO:0034032)	2/35	0.1663335	1	0	0	2.7275827	4.8926297	SULT1C2;SLC26A2
148	negative regulation of nucleotide biosynthetic process (GO:0030809)	2/35	0.1663335	1	0	0	2.7275827	4.8926297	GRM8;ADRA2A
149	multi-organism reproductive process (GO:0044703)	5/140	0.1711062	1	0	0	1.7047392	3.0096678	HSD11B2;MUC1;TFCP2L1;ADRA2A;PTHLH
150	gamma-aminobutyric acid transport (GO:0015812)	1/9	0.1735296	1	0	0	5.3036330	9.2888214	SLC6A1
151	positive regulation of tolerance induction (GO:0002645)	1/9	0.1735296	1	0	0	5.3036330	9.2888214	IRAK3
152	fucose catabolic process (GO:0019317)	1/9	0.1735296	1	0	0	5.3036330	9.2888214	FUT6
153	alkaloid metabolic process (GO:0009820)	1/9	0.1735296	1	0	0	5.3036330	9.2888214	CYP3A5
154	L-fucose metabolic process (GO:0042354)	1/9	0.1735296	1	0	0	5.3036330	9.2888214	FUT6
155	positive regulation of hormone biosynthetic process (GO:0046886)	1/9	0.1735296	1	0	0	5.3036330	9.2888214	CYP17A1
156	positive regulation of osteoblast proliferation (GO:0033690)	1/9	0.1735296	1	0	0	5.3036330	9.2888214	CTHRC1
157	mitochondrial calcium ion transport (GO:0006851)	1/9	0.1735296	1	0	0	5.3036330	9.2888214	BHLHA15
158	tonic smooth muscle contraction (GO:0014820)	1/9	0.1735296	1	0	0	5.3036330	9.2888214	EDN2
159	artery development (GO:0060840)	1/9	0.1735296	1	0	0	5.3036330	9.2888214	NKX3-1
160	endocardial cushion development (GO:0003197)	1/9	0.1735296	1	0	0	5.3036330	9.2888214	THBS1
161	adenosine receptor signaling pathway (GO:0001973)	1/9	0.1735296	1	0	0	5.3036330	9.2888214	ADORA3
162	L-fucose catabolic process (GO:0042355)	1/9	0.1735296	1	0	0	5.3036330	9.2888214	FUT6
163	positive regulation of amino acid transport (GO:0051957)	1/9	0.1735296	1	0	0	5.3036330	9.2888214	SLC6A1
164	eosinophil chemotaxis (GO:0048245)	1/9	0.1735296	1	0	0	5.3036330	9.2888214	CCL24
165	regulation of chemokine secretion (GO:0090196)	1/9	0.1735296	1	0	0	5.3036330	9.2888214	ALOX15B
166	glucose 6-phosphate metabolic process (GO:0051156)	1/9	0.1735296	1	0	0	5.3036330	9.2888214	HKDC1
167	negative regulation of homotypic cell-cell adhesion (GO:0034111)	1/9	0.1735296	1	0	0	5.3036330	9.2888214	C1QTNF1
168	positive regulation of mast cell degranulation (GO:0043306)	1/9	0.1735296	1	0	0	5.3036330	9.2888214	ADORA3
169	positive regulation of mast cell activation involved in immune response (GO:0033008)	1/9	0.1735296	1	0	0	5.3036330	9.2888214	ADORA3
170	retinal rod cell development (GO:0046548)	1/9	0.1735296	1	0	0	5.3036330	9.2888214	NTRK2
171	positive regulation of transcription factor import into nucleus (GO:0042993)	2/36	0.1738152	1	0	0	2.6518165	4.6400487	CSF3;PTGS2
172	negative regulation of cAMP metabolic process (GO:0030815)	2/36	0.1738152	1	0	0	2.6518165	4.6400487	GRM8;ADRA2A
173	negative regulation of response to cytokine stimulus (GO:0060761)	2/36	0.1738152	1	0	0	2.6518165	4.6400487	PXDN;IRAK3
174	positive regulation of protein polymerization (GO:0032273)	3/69	0.1759027	1	0	0	2.0753346	3.6065664	CCL24;CSF3;CDC42EP5
175	negative regulation of cyclic nucleotide metabolic process (GO:0030800)	2/37	0.1813500	1	0	0	2.5801458	4.4051511	GRM8;ADRA2A
176	positive regulation of adenylate cyclase activity (GO:0045762)	2/37	0.1813500	1	0	0	2.5801458	4.4051511	NTRK2;ADORA3
177	regulation of muscle system process (GO:0090257)	5/144	0.1851754	1	0	0	1.6573853	2.7951006	EDN2;STC1;TNNI3;PTGS2;ADRA2A
178	response to interleukin-1 (GO:0070555)	3/71	0.1863944	1	0	0	2.0168745	3.3881279	IRAK3;MYLK3;NKX3-1
179	regulation of wound healing (GO:0061041)	4/107	0.1868587	1	0	0	1.7843999	2.9931571	C1QTNF1;PLAT;THBS1;ADRA2A
180	positive regulation of fat cell differentiation (GO:0045600)	2/38	0.1889323	1	0	0	2.5122472	4.1863248	ZBTB16;PTGS2
181	lung alveolus development (GO:0048286)	2/38	0.1889323	1	0	0	2.5122472	4.1863248	EDN2;PTHLH
182	phospholipid scrambling (GO:0017121)	1/10	0.1908519	1	0	0	4.7732697	7.9057641	ANO7
183	regulation of heat generation (GO:0031650)	1/10	0.1908519	1	0	0	4.7732697	7.9057641	PTGS2
184	nucleoside diphosphate biosynthetic process (GO:0009133)	1/10	0.1908519	1	0	0	4.7732697	7.9057641	ENTPD8
185	regulation of uterine smooth muscle contraction (GO:0070472)	1/10	0.1908519	1	0	0	4.7732697	7.9057641	ADRA2A
186	regulation of macrophage chemotaxis (GO:0010758)	1/10	0.1908519	1	0	0	4.7732697	7.9057641	THBS1
187	auditory receptor cell stereocilium organization (GO:0060088)	1/10	0.1908519	1	0	0	4.7732697	7.9057641	PCDH15
188	positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)	1/10	0.1908519	1	0	0	4.7732697	7.9057641	THBS1
189	surfactant homeostasis (GO:0043129)	1/10	0.1908519	1	0	0	4.7732697	7.9057641	PTHLH
190	positive regulation of pseudopodium assembly (GO:0031274)	1/10	0.1908519	1	0	0	4.7732697	7.9057641	CDC42EP5
191	coenzyme catabolic process (GO:0009109)	1/10	0.1908519	1	0	0	4.7732697	7.9057641	ALDH1L2
192	heart contraction (GO:0060047)	1/10	0.1908519	1	0	0	4.7732697	7.9057641	TNNI3
193	cardiac left ventricle morphogenesis (GO:0003214)	1/10	0.1908519	1	0	0	4.7732697	7.9057641	CPE
194	eosinophil migration (GO:0072677)	1/10	0.1908519	1	0	0	4.7732697	7.9057641	CCL24
195	regulation of plasminogen activation (GO:0010755)	1/10	0.1908519	1	0	0	4.7732697	7.9057641	THBS1
196	long-chain fatty acid biosynthetic process (GO:0042759)	1/10	0.1908519	1	0	0	4.7732697	7.9057641	ALOX15B
197	negative regulation of transcription by competitive promoter binding (GO:0010944)	1/10	0.1908519	1	0	0	4.7732697	7.9057641	MUC1
198	positive regulation of macrophage activation (GO:0043032)	1/10	0.1908519	1	0	0	4.7732697	7.9057641	THBS1
199	positive regulation of keratinocyte differentiation (GO:0045618)	1/10	0.1908519	1	0	0	4.7732697	7.9057641	ALOX15B
200	mitochondrion distribution (GO:0048311)	1/10	0.1908519	1	0	0	4.7732697	7.9057641	BHLHA15
201	regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)	1/10	0.1908519	1	0	0	4.7732697	7.9057641	NKX3-1
202	phospholipid homeostasis (GO:0055091)	1/10	0.1908519	1	0	0	4.7732697	7.9057641	LIPG
203	response to insecticide (GO:0017085)	1/10	0.1908519	1	0	0	4.7732697	7.9057641	CYP17A1
204	histamine transport (GO:0051608)	1/10	0.1908519	1	0	0	4.7732697	7.9057641	ADORA3
205	negative regulation of fibrinolysis (GO:0051918)	1/10	0.1908519	1	0	0	4.7732697	7.9057641	THBS1
206	peripheral nervous system neuron development (GO:0048935)	1/10	0.1908519	1	0	0	4.7732697	7.9057641	NTRK2
207	heart process (GO:0003015)	1/10	0.1908519	1	0	0	4.7732697	7.9057641	TNNI3
208	positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:0036003)	1/10	0.1908519	1	0	0	4.7732697	7.9057641	MUC1
209	regulation of mononuclear cell migration (GO:0071675)	1/10	0.1908519	1	0	0	4.7732697	7.9057641	THBS1
210	positive regulation of blood circulation (GO:1903524)	3/72	0.1917005	1	0	0	1.9888624	3.2852446	EDN2;PTGS2;ADRA2A
211	negative regulation of purine nucleotide metabolic process (GO:1900543)	3/72	0.1917005	1	0	0	1.9888624	3.2852446	GRM8;TNNI3;ADRA2A
212	positive regulation of cAMP metabolic process (GO:0030816)	3/72	0.1917005	1	0	0	1.9888624	3.2852446	NTRK2;ADORA3;PTHLH
213	nucleoside diphosphate metabolic process (GO:0009132)	2/39	0.1965568	1	0	0	2.4478306	3.9821398	ENTPD2;ENTPD8
214	embryo implantation (GO:0007566)	2/39	0.1965568	1	0	0	2.4478306	3.9821398	STC1;PTGS2
215	regulation of oxidative stress-induced cell death (GO:1903201)	2/39	0.1965568	1	0	0	2.4478306	3.9821398	GPR37;PYCR1
216	regulation of cyclase activity (GO:0031279)	3/73	0.1970443	1	0	0	1.9616177	3.1863084	NTRK2;ADORA3;ADRA2A
217	regulation of leukocyte migration (GO:0002685)	4/110	0.1996464	1	0	0	1.7357344	2.7966286	CCL24;EDN2;ADORA3;THBS1
218	response to tumor necrosis factor (GO:0034612)	4/111	0.2039667	1	0	0	1.7200972	2.7346080	APOB;PTGS2;THBS1;NKX3-1
219	bone development (GO:0060348)	2/40	0.2042185	1	0	0	2.3866348	3.7913235	CHAD;STC1
220	anterior/posterior pattern specification (GO:0009952)	5/150	0.2070286	1	0	0	1.5910899	2.5058047	ZBTB16;SIX3;PAX6;FEZF1;NKX3-1
221	regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)	1/11	0.2078120	1	0	0	4.3393361	6.8176239	ALOX15B
222	proline metabolic process (GO:0006560)	1/11	0.2078120	1	0	0	4.3393361	6.8176239	PYCR1
223	regulation of pseudopodium assembly (GO:0031272)	1/11	0.2078120	1	0	0	4.3393361	6.8176239	CDC42EP5
224	positive regulation of endothelial cell apoptotic process (GO:2000353)	1/11	0.2078120	1	0	0	4.3393361	6.8176239	THBS1
225	low-density lipoprotein particle remodeling (GO:0034374)	1/11	0.2078120	1	0	0	4.3393361	6.8176239	APOB
226	regulation of cardiac muscle cell contraction (GO:0086004)	1/11	0.2078120	1	0	0	4.3393361	6.8176239	STC1
227	dopamine biosynthetic process (GO:0042416)	1/11	0.2078120	1	0	0	4.3393361	6.8176239	GPR37
228	mitotic cell cycle arrest (GO:0071850)	1/11	0.2078120	1	0	0	4.3393361	6.8176239	NKX3-1
229	response to lead ion (GO:0010288)	1/11	0.2078120	1	0	0	4.3393361	6.8176239	SLC6A1
230	replicative senescence (GO:0090399)	1/11	0.2078120	1	0	0	4.3393361	6.8176239	WNT16
231	pinocytosis (GO:0006907)	1/11	0.2078120	1	0	0	4.3393361	6.8176239	AHSG
232	oxidative demethylation (GO:0070989)	1/11	0.2078120	1	0	0	4.3393361	6.8176239	CYP3A5
233	positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)	1/11	0.2078120	1	0	0	4.3393361	6.8176239	ADRA2A
234	basement membrane organization (GO:0071711)	1/11	0.2078120	1	0	0	4.3393361	6.8176239	NID2
235	cellular response to prostaglandin stimulus (GO:0071379)	1/11	0.2078120	1	0	0	4.3393361	6.8176239	APOB
236	regulation of energy homeostasis (GO:2000505)	1/11	0.2078120	1	0	0	4.3393361	6.8176239	BMP8A
237	negative regulation of focal adhesion assembly (GO:0051895)	1/11	0.2078120	1	0	0	4.3393361	6.8176239	THBS1
238	regulation of timing of cell differentiation (GO:0048505)	1/11	0.2078120	1	0	0	4.3393361	6.8176239	PAX6
239	negative regulation of adherens junction organization (GO:1903392)	1/11	0.2078120	1	0	0	4.3393361	6.8176239	THBS1
240	negative regulation of cell junction assembly (GO:1901889)	1/11	0.2078120	1	0	0	4.3393361	6.8176239	THBS1
241	response to peptidoglycan (GO:0032494)	1/11	0.2078120	1	0	0	4.3393361	6.8176239	IRAK3
242	negative regulation of myotube differentiation (GO:0010832)	1/11	0.2078120	1	0	0	4.3393361	6.8176239	CEACAM5
243	regulation of lipoprotein metabolic process (GO:0050746)	1/11	0.2078120	1	0	0	4.3393361	6.8176239	LIPG
244	protein heterotrimerization (GO:0070208)	1/11	0.2078120	1	0	0	4.3393361	6.8176239	C1QTNF1
245	negative regulation of nucleotide metabolic process (GO:0045980)	3/75	0.2078374	1	0	0	1.9093079	2.9995211	GRM8;TNNI3;ADRA2A
246	regulation of exocytosis (GO:0017157)	4/112	0.2083144	1	0	0	1.7047392	2.6742360	ADORA3;DOC2B;ADRA2A;STXBP5L
247	regulation of hormone secretion (GO:0046883)	7/230	0.2090308	1	0	0	1.4527343	2.2739268	C1QTNF1;BMP8A;DOC2B;CACNA1E;ADRA2A;STXBP5L;NKX3-1
248	regulation of chondrocyte differentiation (GO:0032330)	2/41	0.2119125	1	0	0	2.3284242	3.6127403	ZBTB16;PTHLH
249	positive regulation of wound healing (GO:0090303)	2/41	0.2119125	1	0	0	2.3284242	3.6127403	THBS1;ADRA2A
250	epidermal cell differentiation (GO:0009913)	3/76	0.2132832	1	0	0	1.8841854	2.9113198	CDSN;PAX6;WNT16
251	regulation of protein kinase B signaling (GO:0051896)	4/114	0.2170882	1	0	0	1.6748315	2.5582241	NTRK2;CSF3;C1QTNF1;THBS1
252	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger (GO:0007187)	5/153	0.2182608	1	0	0	1.5598921	2.3742563	GPR37;ADM2;GRM8;ADRA2A;PTHLH
253	regulation of lyase activity (GO:0051339)	3/77	0.2187594	1	0	0	1.8597155	2.8263638	NTRK2;ADORA3;ADRA2A
254	fatty acid derivative biosynthetic process (GO:1901570)	2/42	0.2196341	1	0	0	2.2729856	3.4453738	EDN2;PTGS2
255	negative regulation of epithelial cell migration (GO:0010633)	2/42	0.2196341	1	0	0	2.2729856	3.4453738	STC1;THBS1
256	icosanoid biosynthetic process (GO:0046456)	2/42	0.2196341	1	0	0	2.2729856	3.4453738	EDN2;PTGS2
257	sterol transport (GO:0015918)	2/42	0.2196341	1	0	0	2.2729856	3.4453738	LIPG;APOB
258	cholesterol transport (GO:0030301)	2/42	0.2196341	1	0	0	2.2729856	3.4453738	LIPG;APOB
259	positive regulation of protein kinase B signaling (GO:0051897)	3/78	0.2242642	1	0	0	1.8358730	2.7445025	CSF3;C1QTNF1;THBS1
260	axis specification (GO:0009798)	3/78	0.2242642	1	0	0	1.8358730	2.7445025	SIX3;STC1;PAX6
261	extracellular fibril organization (GO:0043206)	1/12	0.2244175	1	0	0	3.9777247	5.9437046	MUC5AC
262	regulation of tolerance induction (GO:0002643)	1/12	0.2244175	1	0	0	3.9777247	5.9437046	IRAK3
263	positive regulation of myeloid leukocyte mediated immunity (GO:0002888)	1/12	0.2244175	1	0	0	3.9777247	5.9437046	ADORA3
264	positive regulation of hormone metabolic process (GO:0032352)	1/12	0.2244175	1	0	0	3.9777247	5.9437046	CYP17A1
265	response to manganese ion (GO:0010042)	1/12	0.2244175	1	0	0	3.9777247	5.9437046	PTGS2
266	lens fiber cell differentiation (GO:0070306)	1/12	0.2244175	1	0	0	3.9777247	5.9437046	SIX3
267	positive regulation of cellular amine metabolic process (GO:0033240)	1/12	0.2244175	1	0	0	3.9777247	5.9437046	GPR37
268	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:1902166)	1/12	0.2244175	1	0	0	3.9777247	5.9437046	MUC1
269	regulation of corticosteroid hormone secretion (GO:2000846)	1/12	0.2244175	1	0	0	3.9777247	5.9437046	C1QTNF1
270	G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)	1/12	0.2244175	1	0	0	3.9777247	5.9437046	CHRM1
271	positive regulation of actin cytoskeleton reorganization (GO:2000251)	1/12	0.2244175	1	0	0	3.9777247	5.9437046	CSF3
272	amino acid import (GO:0043090)	1/12	0.2244175	1	0	0	3.9777247	5.9437046	SLC6A1
273	astrocyte differentiation (GO:0048708)	1/12	0.2244175	1	0	0	3.9777247	5.9437046	PAX6
274	regulation of development, heterochronic (GO:0040034)	1/12	0.2244175	1	0	0	3.9777247	5.9437046	PAX6
275	nonmotile primary cilium assembly (GO:0035058)	1/12	0.2244175	1	0	0	3.9777247	5.9437046	PCDH15
276	regulation of platelet aggregation (GO:0090330)	1/12	0.2244175	1	0	0	3.9777247	5.9437046	C1QTNF1
277	startle response (GO:0001964)	1/12	0.2244175	1	0	0	3.9777247	5.9437046	PCDH15
278	regulation of macrophage cytokine production (GO:0010935)	1/12	0.2244175	1	0	0	3.9777247	5.9437046	IRAK3
279	negative regulation of catecholamine secretion (GO:0033604)	1/12	0.2244175	1	0	0	3.9777247	5.9437046	ADRA2A
280	chemical homeostasis within a tissue (GO:0048875)	1/12	0.2244175	1	0	0	3.9777247	5.9437046	PTHLH
281	interleukin-1-mediated signaling pathway (GO:0070498)	1/12	0.2244175	1	0	0	3.9777247	5.9437046	IRAK3
282	endothelial cell morphogenesis (GO:0001886)	1/12	0.2244175	1	0	0	3.9777247	5.9437046	STC1
283	regulation of cholesterol biosynthetic process (GO:0045540)	1/12	0.2244175	1	0	0	3.9777247	5.9437046	APOB
284	iron coordination entity transport (GO:1901678)	1/12	0.2244175	1	0	0	3.9777247	5.9437046	LCN2
285	positive regulation of leukocyte degranulation (GO:0043302)	1/12	0.2244175	1	0	0	3.9777247	5.9437046	ADORA3
286	positive regulation of mast cell activation (GO:0033005)	1/12	0.2244175	1	0	0	3.9777247	5.9437046	ADORA3
287	determination of adult lifespan (GO:0008340)	1/12	0.2244175	1	0	0	3.9777247	5.9437046	TFCP2L1
288	regulation of receptor binding (GO:1900120)	1/12	0.2244175	1	0	0	3.9777247	5.9437046	NKX3-1
289	linoleic acid metabolic process (GO:0043651)	1/12	0.2244175	1	0	0	3.9777247	5.9437046	ALOX15B
290	mesonephros development (GO:0001823)	1/12	0.2244175	1	0	0	3.9777247	5.9437046	ZBTB16
291	negative regulation of blood coagulation (GO:0030195)	2/43	0.2273788	1	0	0	2.2201254	3.2883123	C1QTNF1;PLAT
292	regulation of organic acid transport (GO:0032890)	2/43	0.2273788	1	0	0	2.2201254	3.2883123	SLC6A1;THBS1
293	negative regulation of hemostasis (GO:1900047)	2/43	0.2273788	1	0	0	2.2201254	3.2883123	C1QTNF1;PLAT
294	regulation of blood coagulation (GO:0030193)	3/79	0.2297959	1	0	0	1.8126341	2.6655940	C1QTNF1;PLAT;THBS1
295	calcium-mediated signaling (GO:0019722)	3/79	0.2297959	1	0	0	1.8126341	2.6655940	NTRK2;EDN2;BHLHA15
296	regulation of hemostasis (GO:1900046)	3/79	0.2297959	1	0	0	1.8126341	2.6655940	C1QTNF1;PLAT;THBS1
297	response to organophosphorus (GO:0046683)	4/118	0.2349238	1	0	0	1.6180575	2.3437466	STC1;PLAT;PTGS2;CYP17A1
298	hormone biosynthetic process (GO:0042446)	2/44	0.2351421	1	0	0	2.1696680	3.1407358	TPO;CYP17A1
299	connective tissue development (GO:0061448)	2/44	0.2351421	1	0	0	2.1696680	3.1407358	COMP;THBS1
300	Leydig cell differentiation (GO:0033327)	1/13	0.2406756	1	0	0	3.6717459	5.2296866	CYP17A1
301	drug catabolic process (GO:0042737)	1/13	0.2406756	1	0	0	3.6717459	5.2296866	CYP3A5
302	thyroid hormone generation (GO:0006590)	1/13	0.2406756	1	0	0	3.6717459	5.2296866	TPO
303	chronic inflammatory response (GO:0002544)	1/13	0.2406756	1	0	0	3.6717459	5.2296866	THBS1
304	establishment of tissue polarity (GO:0007164)	1/13	0.2406756	1	0	0	3.6717459	5.2296866	CTHRC1
305	positive regulation of systemic arterial blood pressure (GO:0003084)	1/13	0.2406756	1	0	0	3.6717459	5.2296866	HSD11B2
306	sulfation (GO:0051923)	1/13	0.2406756	1	0	0	3.6717459	5.2296866	SULT1C2
307	phagocytosis, engulfment (GO:0006911)	1/13	0.2406756	1	0	0	3.6717459	5.2296866	THBS1
308	response to auditory stimulus (GO:0010996)	1/13	0.2406756	1	0	0	3.6717459	5.2296866	NTRK2
309	establishment of planar polarity (GO:0001736)	1/13	0.2406756	1	0	0	3.6717459	5.2296866	CTHRC1
310	positive regulation of fatty acid biosynthetic process (GO:0045723)	1/13	0.2406756	1	0	0	3.6717459	5.2296866	PTGS2
311	calcium-mediated signaling using intracellular calcium source (GO:0035584)	1/13	0.2406756	1	0	0	3.6717459	5.2296866	NTRK2
312	lipoprotein transport (GO:0042953)	1/13	0.2406756	1	0	0	3.6717459	5.2296866	APOB
313	cellular response to antibiotic (GO:0071236)	1/13	0.2406756	1	0	0	3.6717459	5.2296866	CYP17A1
314	lung secretory cell differentiation (GO:0061140)	1/13	0.2406756	1	0	0	3.6717459	5.2296866	SPDEF
315	keratinocyte proliferation (GO:0043616)	1/13	0.2406756	1	0	0	3.6717459	5.2296866	WNT16
316	regulation of cholesterol storage (GO:0010885)	1/13	0.2406756	1	0	0	3.6717459	5.2296866	APOB
317	sulfate transmembrane transport (GO:1902358)	1/13	0.2406756	1	0	0	3.6717459	5.2296866	SLC26A2
318	regulation of lipoprotein particle clearance (GO:0010984)	1/13	0.2406756	1	0	0	3.6717459	5.2296866	LIPG
319	negative regulation of cell fate commitment (GO:0010454)	1/13	0.2406756	1	0	0	3.6717459	5.2296866	SPDEF
320	vascular smooth muscle contraction (GO:0014829)	1/13	0.2406756	1	0	0	3.6717459	5.2296866	EDN2
321	sodium-independent organic anion transport (GO:0043252)	1/13	0.2406756	1	0	0	3.6717459	5.2296866	SLCO1B3
322	branching involved in prostate gland morphogenesis (GO:0060442)	1/13	0.2406756	1	0	0	3.6717459	5.2296866	NKX3-1
323	phenol-containing compound metabolic process (GO:0018958)	3/81	0.2409331	1	0	0	1.7678777	2.5161070	TPO;GPR37;CYP17A1
324	response to hypoxia (GO:0001666)	7/241	0.2426279	1	0	0	1.3864269	1.9634941	HSD11B2;MUC1;STC1;PLAT;PTGS2;THBS1;NKX3-1
325	regulation of interleukin-12 production (GO:0032655)	2/45	0.2429200	1	0	0	2.1214532	3.0019049	IRAK3;THBS1
326	negative regulation of ion transmembrane transport (GO:0034766)	2/45	0.2429200	1	0	0	2.1214532	3.0019049	THBS1;ADRA2A
327	regulation of cellular response to oxidative stress (GO:1900407)	2/45	0.2429200	1	0	0	2.1214532	3.0019049	GPR37;PYCR1
328	regulation of blood vessel endothelial cell migration (GO:0043535)	2/45	0.2429200	1	0	0	2.1214532	3.0019049	PTGS2;THBS1
329	positive regulation of cyclic nucleotide biosynthetic process (GO:0030804)	3/82	0.2465352	1	0	0	1.7463182	2.4452827	NTRK2;ADORA3;PTHLH
330	positive regulation of ossification (GO:0045778)	3/83	0.2521575	1	0	0	1.7252782	2.3769184	FBN2;ZBTB16;CTHRC1
331	response to decreased oxygen levels (GO:0036293)	7/245	0.2552533	1	0	0	1.3637913	1.8622555	HSD11B2;MUC1;STC1;PLAT;PTGS2;THBS1;NKX3-1
332	progesterone metabolic process (GO:0042448)	1/14	0.2565938	1	0	0	3.4094783	4.6377803	CYP17A1
333	adrenergic receptor signaling pathway (GO:0071875)	1/14	0.2565938	1	0	0	3.4094783	4.6377803	ADRA2A
334	cell proliferation in forebrain (GO:0021846)	1/14	0.2565938	1	0	0	3.4094783	4.6377803	SIX3
335	regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:1902165)	1/14	0.2565938	1	0	0	3.4094783	4.6377803	MUC1
336	inositol phosphate-mediated signaling (GO:0048016)	1/14	0.2565938	1	0	0	3.4094783	4.6377803	EDN2
337	response to magnesium ion (GO:0032026)	1/14	0.2565938	1	0	0	3.4094783	4.6377803	THBS1
338	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	1/14	0.2565938	1	0	0	3.4094783	4.6377803	GRM8
339	high-density lipoprotein particle remodeling (GO:0034375)	1/14	0.2565938	1	0	0	3.4094783	4.6377803	LIPG
340	gland morphogenesis (GO:0022612)	1/14	0.2565938	1	0	0	3.4094783	4.6377803	PAX6
341	negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)	1/14	0.2565938	1	0	0	3.4094783	4.6377803	THBS1
342	purine ribonucleoside diphosphate metabolic process (GO:0009179)	1/14	0.2565938	1	0	0	3.4094783	4.6377803	ENTPD2
343	purine nucleoside diphosphate metabolic process (GO:0009135)	1/14	0.2565938	1	0	0	3.4094783	4.6377803	ENTPD2
344	macrophage chemotaxis (GO:0048246)	1/14	0.2565938	1	0	0	3.4094783	4.6377803	EDN2
345	dorsal/ventral axis specification (GO:0009950)	1/14	0.2565938	1	0	0	3.4094783	4.6377803	PAX6
346	regulation of steroid hormone biosynthetic process (GO:0090030)	1/14	0.2565938	1	0	0	3.4094783	4.6377803	CYP17A1
347	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator (GO:0006978)	1/14	0.2565938	1	0	0	3.4094783	4.6377803	MUC1
348	fibril organization (GO:0097435)	1/14	0.2565938	1	0	0	3.4094783	4.6377803	MUC5AC
349	regulation of fibrinolysis (GO:0051917)	1/14	0.2565938	1	0	0	3.4094783	4.6377803	THBS1
350	positive regulation of steroid biosynthetic process (GO:0010893)	1/14	0.2565938	1	0	0	3.4094783	4.6377803	CYP17A1
351	regulation of actin filament-based movement (GO:1903115)	1/14	0.2565938	1	0	0	3.4094783	4.6377803	STC1
352	reactive oxygen species metabolic process (GO:0072593)	3/84	0.2577982	1	0	0	1.7047392	2.3109072	TPO;PXDN;IL19
353	positive regulation of purine nucleotide biosynthetic process (GO:1900373)	3/84	0.2577982	1	0	0	1.7047392	2.3109072	NTRK2;ADORA3;PTHLH
354	positive regulation of nucleotide biosynthetic process (GO:0030810)	3/84	0.2577982	1	0	0	1.7047392	2.3109072	NTRK2;ADORA3;PTHLH
355	adenylate cyclase-activating G-protein coupled receptor signaling pathway (GO:0007189)	2/47	0.2585036	1	0	0	2.0311786	2.7478708	ADM2;PTHLH
356	negative regulation of coagulation (GO:0050819)	2/47	0.2585036	1	0	0	2.0311786	2.7478708	C1QTNF1;PLAT
357	negative regulation of synaptic transmission (GO:0050805)	2/47	0.2585036	1	0	0	2.0311786	2.7478708	SLC6A1;PTGS2
358	positive regulation of cyclase activity (GO:0031281)	2/47	0.2585036	1	0	0	2.0311786	2.7478708	NTRK2;ADORA3
359	regulation of coagulation (GO:0050818)	3/85	0.2634558	1	0	0	1.6846834	2.2471480	C1QTNF1;PLAT;THBS1
360	regulation of anion transport (GO:0044070)	3/85	0.2634558	1	0	0	1.6846834	2.2471480	STC1;SLC6A1;THBS1
361	regulation of calcium ion transmembrane transport (GO:1903169)	2/48	0.2663018	1	0	0	1.9888624	2.6315136	JPH2;ADRA2A
362	regulation of calcium ion transmembrane transporter activity (GO:1901019)	2/48	0.2663018	1	0	0	1.9888624	2.6315136	JPH2;ADRA2A
363	positive regulation of intrinsic apoptotic signaling pathway (GO:2001244)	2/48	0.2663018	1	0	0	1.9888624	2.6315136	IL19;NKX3-1
364	Rho protein signal transduction (GO:0007266)	2/48	0.2663018	1	0	0	1.9888624	2.6315136	CDC42EP5;ADRA2A
365	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	1/15	0.2721791	1	0	0	3.1821798	4.1409551	DOC2B
366	androgen biosynthetic process (GO:0006702)	1/15	0.2721791	1	0	0	3.1821798	4.1409551	CYP17A1
367	embryonic camera-type eye morphogenesis (GO:0048596)	1/15	0.2721791	1	0	0	3.1821798	4.1409551	PAX6
368	glandular epithelial cell development (GO:0002068)	1/15	0.2721791	1	0	0	3.1821798	4.1409551	PAX6
369	granulocyte differentiation (GO:0030851)	1/15	0.2721791	1	0	0	3.1821798	4.1409551	CSF3
370	sulfate transport (GO:0008272)	1/15	0.2721791	1	0	0	3.1821798	4.1409551	SLC26A2
371	regulation of norepinephrine secretion (GO:0014061)	1/15	0.2721791	1	0	0	3.1821798	4.1409551	ADRA2A
372	positive regulation of cholesterol transport (GO:0032376)	1/15	0.2721791	1	0	0	3.1821798	4.1409551	LIPG
373	regulation of cell migration involved in sprouting angiogenesis (GO:0090049)	1/15	0.2721791	1	0	0	3.1821798	4.1409551	PTGS2
374	regulation of dopamine metabolic process (GO:0042053)	1/15	0.2721791	1	0	0	3.1821798	4.1409551	GPR37
375	positive regulation of epidermal cell differentiation (GO:0045606)	1/15	0.2721791	1	0	0	3.1821798	4.1409551	ALOX15B
376	cyclooxygenase pathway (GO:0019371)	1/15	0.2721791	1	0	0	3.1821798	4.1409551	PTGS2
377	acrosome reaction (GO:0007340)	1/15	0.2721791	1	0	0	3.1821798	4.1409551	SYT8
378	pharyngeal system development (GO:0060037)	1/15	0.2721791	1	0	0	3.1821798	4.1409551	NKX3-1
379	DNA damage response, signal transduction resulting in transcription (GO:0042772)	1/15	0.2721791	1	0	0	3.1821798	4.1409551	MUC1
380	positive regulation of membrane protein ectodomain proteolysis (GO:0051044)	1/15	0.2721791	1	0	0	3.1821798	4.1409551	ADRA2A
381	response to food (GO:0032094)	1/15	0.2721791	1	0	0	3.1821798	4.1409551	HSD11B2
382	negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)	1/15	0.2721791	1	0	0	3.1821798	4.1409551	MUC1
383	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	1/15	0.2721791	1	0	0	3.1821798	4.1409551	PCDH15
384	hair cycle (GO:0042633)	1/15	0.2721791	1	0	0	3.1821798	4.1409551	PTGS2
385	positive regulation of sterol transport (GO:0032373)	1/15	0.2721791	1	0	0	3.1821798	4.1409551	LIPG
386	extracellular negative regulation of signal transduction (GO:1900116)	1/15	0.2721791	1	0	0	3.1821798	4.1409551	FBN2
387	extracellular regulation of signal transduction (GO:1900115)	1/15	0.2721791	1	0	0	3.1821798	4.1409551	FBN2
388	negative regulation of chondrocyte differentiation (GO:0032331)	1/15	0.2721791	1	0	0	3.1821798	4.1409551	PTHLH
389	molting cycle (GO:0042303)	1/15	0.2721791	1	0	0	3.1821798	4.1409551	PTGS2
390	renal system process involved in regulation of blood volume (GO:0001977)	1/15	0.2721791	1	0	0	3.1821798	4.1409551	HSD11B2
391	dicarboxylic acid catabolic process (GO:0043649)	1/15	0.2721791	1	0	0	3.1821798	4.1409551	ALDH1L2
392	negative regulation of platelet activation (GO:0010544)	1/15	0.2721791	1	0	0	3.1821798	4.1409551	C1QTNF1
393	regulation of catecholamine metabolic process (GO:0042069)	1/15	0.2721791	1	0	0	3.1821798	4.1409551	GPR37
394	regulation of response to oxidative stress (GO:1902882)	2/49	0.2740994	1	0	0	1.9482733	2.5215808	GPR37;PYCR1
395	cellular glucose homeostasis (GO:0001678)	2/49	0.2740994	1	0	0	1.9482733	2.5215808	HKDC1;FOXA3
396	positive regulation of exocytosis (GO:0045921)	2/49	0.2740994	1	0	0	1.9482733	2.5215808	ADORA3;DOC2B
397	fatty acid derivative metabolic process (GO:1901568)	3/88	0.2805142	1	0	0	1.6272510	2.0684488	EDN2;PTGS2;ALOX15B
398	positive regulation of inflammatory response (GO:0050729)	3/88	0.2805142	1	0	0	1.6272510	2.0684488	CCL24;ADORA3;PTGS2
399	icosanoid metabolic process (GO:0006690)	3/88	0.2805142	1	0	0	1.6272510	2.0684488	EDN2;PTGS2;ALOX15B
400	regulation of insulin secretion (GO:0050796)	5/169	0.2809033	1	0	0	1.4122100	1.7931463	BMP8A;DOC2B;CACNA1E;ADRA2A;STXBP5L
401	determination of left/right symmetry (GO:0007368)	2/50	0.2818931	1	0	0	1.9093079	2.4176177	LEFTY1;DAAM2
402	negative regulation of wound healing (GO:0061045)	2/50	0.2818931	1	0	0	1.9093079	2.4176177	C1QTNF1;PLAT
403	response to fatty acid (GO:0070542)	2/50	0.2818931	1	0	0	1.9093079	2.4176177	PTGS2;APOB
404	positive regulation of lyase activity (GO:0051349)	2/50	0.2818931	1	0	0	1.9093079	2.4176177	NTRK2;ADORA3
405	tissue homeostasis (GO:0001894)	4/129	0.2855315	1	0	0	1.4800836	1.8551413	AZGP1;TFF1;PTHLH;MUC6
406	cellular response to tumor necrosis factor (GO:0071356)	3/89	0.2862238	1	0	0	1.6089673	2.0127878	APOB;THBS1;NKX3-1
407	fucosylation (GO:0036065)	1/16	0.2874383	1	0	0	2.9832936	3.7194122	FUT6
408	cardiac myofibril assembly (GO:0055003)	1/16	0.2874383	1	0	0	2.9832936	3.7194122	MYLK3
409	negative regulation of bone mineralization (GO:0030502)	1/16	0.2874383	1	0	0	2.9832936	3.7194122	AHSG
410	regulation of tumor necrosis factor biosynthetic process (GO:0042534)	1/16	0.2874383	1	0	0	2.9832936	3.7194122	THBS1
411	positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)	1/16	0.2874383	1	0	0	2.9832936	3.7194122	THBS1
412	thyroid hormone metabolic process (GO:0042403)	1/16	0.2874383	1	0	0	2.9832936	3.7194122	TPO
413	positive regulation of calcium ion import (GO:0090280)	1/16	0.2874383	1	0	0	2.9832936	3.7194122	STC1
414	regulation of cellular senescence (GO:2000772)	1/16	0.2874383	1	0	0	2.9832936	3.7194122	NEK6
415	fucose metabolic process (GO:0006004)	1/16	0.2874383	1	0	0	2.9832936	3.7194122	FUT6
416	plasma lipoprotein particle assembly (GO:0034377)	1/16	0.2874383	1	0	0	2.9832936	3.7194122	APOB
417	reverse cholesterol transport (GO:0043691)	1/16	0.2874383	1	0	0	2.9832936	3.7194122	LIPG
418	behavioral response to pain (GO:0048266)	1/16	0.2874383	1	0	0	2.9832936	3.7194122	THBS1
419	phasic smooth muscle contraction (GO:0014821)	1/16	0.2874383	1	0	0	2.9832936	3.7194122	EDN2
420	columnar/cuboidal epithelial cell differentiation (GO:0002065)	2/51	0.2896796	1	0	0	1.8718705	2.3192094	PAX6;SPDEF
421	regulation of potassium ion transport (GO:0043266)	2/51	0.2896796	1	0	0	1.8718705	2.3192094	KCNN2;ADRA2A
422	negative regulation of transmembrane transport (GO:0034763)	2/51	0.2896796	1	0	0	1.8718705	2.3192094	THBS1;ADRA2A
423	circulatory system process (GO:0003013)	4/130	0.2902174	1	0	0	1.4686984	1.8169632	EDN2;TNNI3;MYLK3;F5
424	response to glucocorticoid (GO:0051384)	4/130	0.2902174	1	0	0	1.4686984	1.8169632	HSD11B2;STC1;PLAT;PTGS2
425	response to cAMP (GO:0051591)	3/90	0.2919426	1	0	0	1.5910899	1.9589468	STC1;PLAT;CYP17A1
426	memory (GO:0007613)	3/90	0.2919426	1	0	0	1.5910899	1.9589468	NTRK2;CUX2;PTGS2
427	positive regulation of epithelial cell differentiation (GO:0030858)	2/52	0.2974559	1	0	0	1.8358730	2.2259765	PAX6;ALOX15B
428	phospholipase C-activating G-protein coupled receptor signaling pathway (GO:0007200)	2/52	0.2974559	1	0	0	1.8358730	2.2259765	CHRM1;ADRA2A
429	positive regulation of lipid biosynthetic process (GO:0046889)	2/52	0.2974559	1	0	0	1.8358730	2.2259765	PTGS2;CYP17A1
430	positive regulation of hormone secretion (GO:0046887)	3/91	0.2976692	1	0	0	1.5736054	1.9068519	C1QTNF1;DOC2B;NKX3-1
431	positive regulation of cyclic nucleotide metabolic process (GO:0030801)	3/91	0.2976692	1	0	0	1.5736054	1.9068519	NTRK2;ADORA3;PTHLH
432	response to oxygen levels (GO:0070482)	7/259	0.3008117	1	0	0	1.2900729	1.5497270	HSD11B2;MUC1;STC1;PLAT;PTGS2;THBS1;NKX3-1
433	cellular modified amino acid catabolic process (GO:0042219)	1/17	0.3023784	1	0	0	2.8078057	3.3583490	ALDH1L2
434	positive regulation of regulated secretory pathway (GO:1903307)	1/17	0.3023784	1	0	0	2.8078057	3.3583490	ADORA3
435	G-protein coupled purinergic receptor signaling pathway (GO:0035588)	1/17	0.3023784	1	0	0	2.8078057	3.3583490	ADORA3
436	azole transport (GO:0045117)	1/17	0.3023784	1	0	0	2.8078057	3.3583490	ADORA3
437	ribonucleoside bisphosphate biosynthetic process (GO:0034030)	1/17	0.3023784	1	0	0	2.8078057	3.3583490	SLC26A2
438	negative regulation of organic acid transport (GO:0032891)	1/17	0.3023784	1	0	0	2.8078057	3.3583490	THBS1
439	cofactor catabolic process (GO:0051187)	1/17	0.3023784	1	0	0	2.8078057	3.3583490	ALDH1L2
440	purine nucleoside bisphosphate biosynthetic process (GO:0034033)	1/17	0.3023784	1	0	0	2.8078057	3.3583490	SLC26A2
441	bone remodeling (GO:0046849)	1/17	0.3023784	1	0	0	2.8078057	3.3583490	WNT16
442	nucleoside bisphosphate biosynthetic process (GO:0033866)	1/17	0.3023784	1	0	0	2.8078057	3.3583490	SLC26A2
443	regulation of cell fate specification (GO:0042659)	1/17	0.3023784	1	0	0	2.8078057	3.3583490	PAX6
444	regulation of vesicle fusion (GO:0031338)	1/17	0.3023784	1	0	0	2.8078057	3.3583490	DOC2B
445	ribonucleoside diphosphate metabolic process (GO:0009185)	1/17	0.3023784	1	0	0	2.8078057	3.3583490	ENTPD2
446	muscle cell migration (GO:0014812)	1/17	0.3023784	1	0	0	2.8078057	3.3583490	PLAT
447	sex differentiation (GO:0007548)	1/17	0.3023784	1	0	0	2.8078057	3.3583490	CYP17A1
448	regulation of endothelial cell migration (GO:0010594)	3/92	0.3034021	1	0	0	1.5565010	1.8564331	STC1;PTGS2;THBS1
449	regulation of blood pressure (GO:0008217)	4/133	0.3043351	1	0	0	1.4355698	1.7077909	HSD11B2;EDN2;ADM2;PTGS2
450	determination of bilateral symmetry (GO:0009855)	2/53	0.3052188	1	0	0	1.8012338	2.1375715	LEFTY1;DAAM2
451	regulation of steroid biosynthetic process (GO:0050810)	2/53	0.3052188	1	0	0	1.8012338	2.1375715	APOB;CYP17A1
452	positive regulation of protein binding (GO:0032092)	2/53	0.3052188	1	0	0	1.8012338	2.1375715	CSF3;CTHRC1
453	granulocyte chemotaxis (GO:0071621)	2/53	0.3052188	1	0	0	1.8012338	2.1375715	CCL24;EDN2
454	regulation of cartilage development (GO:0061035)	2/54	0.3129657	1	0	0	1.7678777	2.0536758	ZBTB16;PTHLH
455	specification of symmetry (GO:0009799)	2/54	0.3129657	1	0	0	1.7678777	2.0536758	LEFTY1;DAAM2
456	gland development (GO:0048732)	6/220	0.3146673	1	0	0	1.3018008	1.5051934	SIX3;PAX6;TFCP2L1;ALOX15B;CYP17A1;NKX3-1
457	cellular response to toxic substance (GO:0097237)	1/18	0.3170060	1	0	0	2.6518165	3.0464985	CYP17A1
458	tetrahydrofolate metabolic process (GO:0046653)	1/18	0.3170060	1	0	0	2.6518165	3.0464985	ALDH1L2
459	negative regulation of calcium ion transmembrane transport (GO:1903170)	1/18	0.3170060	1	0	0	2.6518165	3.0464985	ADRA2A
460	cytokine biosynthetic process (GO:0042089)	1/18	0.3170060	1	0	0	2.6518165	3.0464985	IL19
461	catechol-containing compound biosynthetic process (GO:0009713)	1/18	0.3170060	1	0	0	2.6518165	3.0464985	GPR37
462	negative regulation of cytokine production involved in immune response (GO:0002719)	1/18	0.3170060	1	0	0	2.6518165	3.0464985	IRAK3
463	catecholamine biosynthetic process (GO:0042423)	1/18	0.3170060	1	0	0	2.6518165	3.0464985	GPR37
464	fibrinolysis (GO:0042730)	1/18	0.3170060	1	0	0	2.6518165	3.0464985	PLAT
465	olfactory bulb development (GO:0021772)	1/18	0.3170060	1	0	0	2.6518165	3.0464985	FEZF1
466	telencephalon development (GO:0021537)	1/18	0.3170060	1	0	0	2.6518165	3.0464985	SIX3
467	regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902253)	1/18	0.3170060	1	0	0	2.6518165	3.0464985	MUC1
468	positive regulation of excitatory postsynaptic membrane potential (GO:2000463)	1/18	0.3170060	1	0	0	2.6518165	3.0464985	CUX2
469	cellular response to gonadotropin stimulus (GO:0071371)	1/18	0.3170060	1	0	0	2.6518165	3.0464985	CYP17A1
470	negative regulation of calcium ion transmembrane transporter activity (GO:1901020)	1/18	0.3170060	1	0	0	2.6518165	3.0464985	ADRA2A
471	phospholipid translocation (GO:0045332)	1/18	0.3170060	1	0	0	2.6518165	3.0464985	ATP10B
472	virion assembly (GO:0019068)	1/18	0.3170060	1	0	0	2.6518165	3.0464985	RAB43
473	regulation of antigen processing and presentation (GO:0002577)	1/18	0.3170060	1	0	0	2.6518165	3.0464985	THBS1
474	hindbrain development (GO:0030902)	1/18	0.3170060	1	0	0	2.6518165	3.0464985	PAX6
475	glutamate secretion (GO:0014047)	1/18	0.3170060	1	0	0	2.6518165	3.0464985	NTRK2
476	protein-lipid complex assembly (GO:0065005)	1/18	0.3170060	1	0	0	2.6518165	3.0464985	APOB
477	positive regulation of dendritic spine development (GO:0060999)	1/18	0.3170060	1	0	0	2.6518165	3.0464985	CUX2
478	lipid translocation (GO:0034204)	1/18	0.3170060	1	0	0	2.6518165	3.0464985	ATP10B
479	regulation of mast cell degranulation (GO:0043304)	1/18	0.3170060	1	0	0	2.6518165	3.0464985	ADORA3
480	positive regulation of chondrocyte differentiation (GO:0032332)	1/18	0.3170060	1	0	0	2.6518165	3.0464985	ZBTB16
481	negative regulation of biomineral tissue development (GO:0070168)	1/18	0.3170060	1	0	0	2.6518165	3.0464985	AHSG
482	positive regulation of lipid storage (GO:0010884)	1/18	0.3170060	1	0	0	2.6518165	3.0464985	APOB
483	regulation of synaptic transmission, dopaminergic (GO:0032225)	1/18	0.3170060	1	0	0	2.6518165	3.0464985	PTGS2
484	regulation of Rac GTPase activity (GO:0032314)	1/18	0.3170060	1	0	0	2.6518165	3.0464985	NTRK2
485	protein glycosylation (GO:0006486)	7/264	0.3174937	1	0	0	1.2656397	1.4520649	FUT6;MUC1;B3GNT6;MUC3A;ABO;MUC5AC;MUC6
486	macromolecule glycosylation (GO:0043413)	7/264	0.3174937	1	0	0	1.2656397	1.4520649	FUT6;MUC1;B3GNT6;MUC3A;ABO;MUC5AC;MUC6
487	positive regulation of endothelial cell migration (GO:0010595)	2/55	0.3206937	1	0	0	1.7357344	1.9739967	PTGS2;THBS1
488	arachidonic acid metabolic process (GO:0019369)	2/55	0.3206937	1	0	0	1.7357344	1.9739967	PTGS2;ALOX15B
489	granulocyte migration (GO:0097530)	2/55	0.3206937	1	0	0	1.7357344	1.9739967	CCL24;EDN2
490	positive regulation of leukocyte chemotaxis (GO:0002690)	2/56	0.3284002	1	0	0	1.7047392	1.8982650	EDN2;THBS1
491	positive regulation of neuroblast proliferation (GO:0002052)	1/19	0.3313276	1	0	0	2.5122472	2.7751481	PAX6
492	reflex (GO:0060004)	1/19	0.3313276	1	0	0	2.5122472	2.7751481	PCDH15
493	regulation of fibroblast migration (GO:0010762)	1/19	0.3313276	1	0	0	2.5122472	2.7751481	THBS1
494	cardiac epithelial to mesenchymal transition (GO:0060317)	1/19	0.3313276	1	0	0	2.5122472	2.7751481	WNT16
495	osteoblast development (GO:0002076)	1/19	0.3313276	1	0	0	2.5122472	2.7751481	PTHLH
496	appendage development (GO:0048736)	1/19	0.3313276	1	0	0	2.5122472	2.7751481	COMP
497	positive regulation of calcium ion transmembrane transporter activity (GO:1901021)	1/19	0.3313276	1	0	0	2.5122472	2.7751481	JPH2
498	triglyceride catabolic process (GO:0019433)	1/19	0.3313276	1	0	0	2.5122472	2.7751481	APOB
499	limb development (GO:0060173)	1/19	0.3313276	1	0	0	2.5122472	2.7751481	COMP
500	regulation of membrane protein ectodomain proteolysis (GO:0051043)	1/19	0.3313276	1	0	0	2.5122472	2.7751481	ADRA2A
501	positive regulation of heart rate (GO:0010460)	1/19	0.3313276	1	0	0	2.5122472	2.7751481	EDN2
502	intestinal absorption (GO:0050892)	1/19	0.3313276	1	0	0	2.5122472	2.7751481	ADRA2A
503	glutamine family amino acid biosynthetic process (GO:0009084)	1/19	0.3313276	1	0	0	2.5122472	2.7751481	PYCR1
504	positive regulation of histone acetylation (GO:0035066)	1/19	0.3313276	1	0	0	2.5122472	2.7751481	MUC1
505	regulation of mast cell activation involved in immune response (GO:0033006)	1/19	0.3313276	1	0	0	2.5122472	2.7751481	ADORA3
506	membrane invagination (GO:0010324)	1/19	0.3313276	1	0	0	2.5122472	2.7751481	THBS1
507	response to carbohydrate (GO:0009743)	4/139	0.3327663	1	0	0	1.3736028	1.5113956	APOB;SLC6A1;PTGS2;THBS1
508	Golgi organization (GO:0007030)	2/57	0.3360828	1	0	0	1.6748315	1.8262323	RAB43;BHLHA15
509	neurotransmitter secretion (GO:0007269)	2/57	0.3360828	1	0	0	1.6748315	1.8262323	DOC2B;SLC6A1
510	dicarboxylic acid transport (GO:0006835)	2/57	0.3360828	1	0	0	1.6748315	1.8262323	NTRK2;SLC13A5
511	response to corticosteroid (GO:0031960)	4/140	0.3375210	1	0	0	1.3637913	1.4812513	HSD11B2;STC1;PLAT;PTGS2
512	cell cycle arrest (GO:0007050)	4/140	0.3375210	1	0	0	1.3637913	1.4812513	CGREF1;BRINP1;THBS1;NKX3-1
513	cellular response to hypoxia (GO:0071456)	3/99	0.3435957	1	0	0	1.4464454	1.5452227	STC1;PTGS2;NKX3-1
514	negative regulation of lipid catabolic process (GO:0050995)	1/20	0.3453496	1	0	0	2.3866348	2.5374656	ADRA2A
515	regulation of osteoblast proliferation (GO:0033688)	1/20	0.3453496	1	0	0	2.3866348	2.5374656	CTHRC1
516	regulation of transcription involved in cell fate commitment (GO:0060850)	1/20	0.3453496	1	0	0	2.3866348	2.5374656	PAX6
517	renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)	1/20	0.3453496	1	0	0	2.3866348	2.5374656	HSD11B2
518	positive regulation of organelle assembly (GO:1902117)	1/20	0.3453496	1	0	0	2.3866348	2.5374656	MYLK3
519	neuromuscular synaptic transmission (GO:0007274)	1/20	0.3453496	1	0	0	2.3866348	2.5374656	CHRM1
520	positive regulation of epidermal growth factor receptor signaling pathway (GO:0045742)	1/20	0.3453496	1	0	0	2.3866348	2.5374656	ADRA2A
521	negative regulation of cartilage development (GO:0061037)	1/20	0.3453496	1	0	0	2.3866348	2.5374656	PTHLH
522	acidic amino acid transport (GO:0015800)	1/20	0.3453496	1	0	0	2.3866348	2.5374656	SLC6A1
523	regulation of amino acid transport (GO:0051955)	1/20	0.3453496	1	0	0	2.3866348	2.5374656	SLC6A1
524	cobalamin metabolic process (GO:0009235)	1/20	0.3453496	1	0	0	2.3866348	2.5374656	TCN1
525	regulation of cholesterol metabolic process (GO:0090181)	1/20	0.3453496	1	0	0	2.3866348	2.5374656	APOB
526	negative regulation of striated muscle cell differentiation (GO:0051154)	1/20	0.3453496	1	0	0	2.3866348	2.5374656	CEACAM5
527	response to prostaglandin (GO:0034694)	1/20	0.3453496	1	0	0	2.3866348	2.5374656	APOB
528	plasma lipoprotein particle clearance (GO:0034381)	1/20	0.3453496	1	0	0	2.3866348	2.5374656	APOB
529	activation of protein kinase B activity (GO:0032148)	1/20	0.3453496	1	0	0	2.3866348	2.5374656	ADRA2A
530	regulation of homotypic cell-cell adhesion (GO:0034110)	1/20	0.3453496	1	0	0	2.3866348	2.5374656	C1QTNF1
531	negative regulation of blood vessel endothelial cell migration (GO:0043537)	1/20	0.3453496	1	0	0	2.3866348	2.5374656	THBS1
532	positive regulation of cytoskeleton organization (GO:0051495)	4/142	0.3470374	1	0	0	1.3445830	1.4230026	CCL24;CSF3;CDC42EP5;MYLK3
533	glycosylation (GO:0070085)	7/273	0.3478975	1	0	0	1.2239153	1.2922679	FUT6;MUC1;B3GNT6;MUC3A;ABO;MUC5AC;MUC6
534	positive regulation of secretion (GO:0051047)	7/273	0.3478975	1	0	0	1.2239153	1.2922679	C1QTNF1;ADORA3;DOC2B;SLC6A1;ALOX15B;STXBP5L;NKX3-1
535	response to estradiol (GO:0032355)	3/100	0.3493311	1	0	0	1.4319809	1.5060645	TFF1;SLC6A1;PTGS2
536	unsaturated fatty acid metabolic process (GO:0033559)	3/100	0.3493311	1	0	0	1.4319809	1.5060645	EDN2;PTGS2;ALOX15B
537	positive regulation of ion transport (GO:0043270)	5/186	0.3506516	1	0	0	1.2831370	1.3446791	JPH2;CHRM1;STC1;SLC6A1;ADRA2A
538	positive regulation of osteoblast differentiation (GO:0045669)	2/59	0.3513668	1	0	0	1.6180575	1.6923662	FBN2;CTHRC1
539	acute inflammatory response (GO:0002526)	2/59	0.3513668	1	0	0	1.6180575	1.6923662	AHSG;ADRA2A
540	cellular response to decreased oxygen levels (GO:0036294)	3/101	0.3550613	1	0	0	1.4178029	1.4680850	STC1;PTGS2;NKX3-1
541	regulation of peptide transport (GO:0090087)	6/231	0.3553968	1	0	0	1.2398103	1.2826091	BMP8A;DOC2B;PTGS2;CACNA1E;ADRA2A;STXBP5L
542	regulation of amine transport (GO:0051952)	2/60	0.3589637	1	0	0	1.5910899	1.6301255	SLC6A1;ADRA2A
543	negative regulation of production of molecular mediator of immune response (GO:0002701)	1/21	0.3590782	1	0	0	2.2729856	2.3280260	IRAK3
544	positive regulation of T cell mediated cytotoxicity (GO:0001916)	1/21	0.3590782	1	0	0	2.2729856	2.3280260	AZGP1
545	neutral lipid catabolic process (GO:0046461)	1/21	0.3590782	1	0	0	2.2729856	2.3280260	APOB
546	positive regulation of peptidyl-lysine acetylation (GO:2000758)	1/21	0.3590782	1	0	0	2.2729856	2.3280260	MUC1
547	acylglycerol catabolic process (GO:0046464)	1/21	0.3590782	1	0	0	2.2729856	2.3280260	APOB
548	regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)	1/21	0.3590782	1	0	0	2.2729856	2.3280260	NKX3-1
549	negative regulation of exocytosis (GO:0045920)	1/21	0.3590782	1	0	0	2.2729856	2.3280260	ADRA2A
550	embryonic eye morphogenesis (GO:0048048)	1/21	0.3590782	1	0	0	2.2729856	2.3280260	PAX6
551	C21-steroid hormone metabolic process (GO:0008207)	1/21	0.3590782	1	0	0	2.2729856	2.3280260	CYP17A1
552	regulation of dendritic spine morphogenesis (GO:0061001)	1/21	0.3590782	1	0	0	2.2729856	2.3280260	CUX2
553	mechanoreceptor differentiation (GO:0042490)	1/21	0.3590782	1	0	0	2.2729856	2.3280260	NTRK2
554	positive regulation of dendrite morphogenesis (GO:0050775)	1/21	0.3590782	1	0	0	2.2729856	2.3280260	CUX2
555	positive regulation of ERBB signaling pathway (GO:1901186)	1/21	0.3590782	1	0	0	2.2729856	2.3280260	ADRA2A
556	positive regulation of protein acetylation (GO:1901985)	1/21	0.3590782	1	0	0	2.2729856	2.3280260	MUC1
557	regulation of peptide hormone secretion (GO:0090276)	5/189	0.3631093	1	0	0	1.2627698	1.2792506	BMP8A;DOC2B;CACNA1E;ADRA2A;STXBP5L
558	glial cell differentiation (GO:0010001)	2/61	0.3665279	1	0	0	1.5650065	1.5707667	NTRK2;PAX6
559	sensory perception of smell (GO:0007608)	2/61	0.3665279	1	0	0	1.5650065	1.5707667	OMP;GRM8
560	cholesterol homeostasis (GO:0042632)	2/61	0.3665279	1	0	0	1.5650065	1.5707667	LIPG;APOB
561	response to steroid hormone (GO:0048545)	9/369	0.3691084	1	0	0	1.1642121	1.1603295	HSD11B2;STC1;TFF1;PLAT;SLC6A1;PTGS2;THBS1;CYP17A1;NKX3-1
562	regulation of actin filament polymerization (GO:0030833)	3/104	0.3722086	1	0	0	1.3769047	1.3607960	CCL24;CSF3;CDC42EP5
563	Wnt signaling pathway, planar cell polarity pathway (GO:0060071)	1/22	0.3725196	1	0	0	2.1696680	2.1424725	CTHRC1
564	cochlea morphogenesis (GO:0090103)	1/22	0.3725196	1	0	0	2.1696680	2.1424725	CTHRC1
565	regulation of hormone biosynthetic process (GO:0046885)	1/22	0.3725196	1	0	0	2.1696680	2.1424725	CYP17A1
566	myofibril assembly (GO:0030239)	1/22	0.3725196	1	0	0	2.1696680	2.1424725	MYLK3
567	negative regulation of toll-like receptor signaling pathway (GO:0034122)	1/22	0.3725196	1	0	0	2.1696680	2.1424725	IRAK3
568	negative regulation of amine transport (GO:0051953)	1/22	0.3725196	1	0	0	2.1696680	2.1424725	ADRA2A
569	cytokine metabolic process (GO:0042107)	1/22	0.3725196	1	0	0	2.1696680	2.1424725	IL19
570	mitochondrion localization (GO:0051646)	1/22	0.3725196	1	0	0	2.1696680	2.1424725	BHLHA15
571	signal transduction involved in regulation of gene expression (GO:0023019)	1/22	0.3725196	1	0	0	2.1696680	2.1424725	PAX6
572	apoptotic process involved in development (GO:1902742)	1/22	0.3725196	1	0	0	2.1696680	2.1424725	SIX3
573	cellular response to hydrogen peroxide (GO:0070301)	2/62	0.3740573	1	0	0	1.5397644	1.5141217	TPO;PXDN
574	sterol homeostasis (GO:0055092)	2/62	0.3740573	1	0	0	1.5397644	1.5141217	LIPG;APOB
575	cellular response to retinoic acid (GO:0071300)	2/62	0.3740573	1	0	0	1.5397644	1.5141217	MUC1;BRINP1
576	regulation of peptide secretion (GO:0002791)	5/192	0.3755773	1	0	0	1.2430390	1.2172969	BMP8A;DOC2B;CACNA1E;ADRA2A;STXBP5L
577	cellular response to oxidative stress (GO:0034599)	4/148	0.3755906	1	0	0	1.2900729	1.2633110	TPO;PXDN;PYCR1;WNT16
578	response to transition metal nanoparticle (GO:1990267)	3/106	0.3835932	1	0	0	1.3509254	1.2944199	TFF1;PTGS2;CYP17A1
579	response to ATP (GO:0033198)	1/23	0.3856798	1	0	0	2.0753346	1.9772706	PTGS2
580	oligodendrocyte differentiation (GO:0048709)	1/23	0.3856798	1	0	0	2.0753346	1.9772706	NTRK2
581	cell aggregation (GO:0098743)	1/23	0.3856798	1	0	0	2.0753346	1.9772706	CHAD
582	regulation of establishment of planar polarity (GO:0090175)	1/23	0.3856798	1	0	0	2.0753346	1.9772706	CTHRC1
583	regulation of keratinocyte differentiation (GO:0045616)	1/23	0.3856798	1	0	0	2.0753346	1.9772706	ALOX15B
584	benzene-containing compound metabolic process (GO:0042537)	1/23	0.3856798	1	0	0	2.0753346	1.9772706	CYP17A1
585	positive regulation vascular endothelial growth factor production (GO:0010575)	1/23	0.3856798	1	0	0	2.0753346	1.9772706	PTGS2
586	positive regulation of potassium ion transport (GO:0043268)	1/23	0.3856798	1	0	0	2.0753346	1.9772706	ADRA2A
587	positive regulation of transforming growth factor beta receptor signaling pathway (GO:0030511)	1/23	0.3856798	1	0	0	2.0753346	1.9772706	THBS1
588	positive regulation of NF-kappaB import into nucleus (GO:0042346)	1/23	0.3856798	1	0	0	2.0753346	1.9772706	PTGS2
589	cholesterol efflux (GO:0033344)	1/23	0.3856798	1	0	0	2.0753346	1.9772706	APOB
590	positive regulation of organic acid transport (GO:0032892)	1/23	0.3856798	1	0	0	2.0753346	1.9772706	SLC6A1
591	positive regulation of amine transport (GO:0051954)	1/23	0.3856798	1	0	0	2.0753346	1.9772706	SLC6A1
592	multicellular organism reproduction (GO:0032504)	1/23	0.3856798	1	0	0	2.0753346	1.9772706	CATSPERB
593	regulation of macrophage activation (GO:0043030)	1/23	0.3856798	1	0	0	2.0753346	1.9772706	THBS1
594	regulation of fatty acid transport (GO:2000191)	1/23	0.3856798	1	0	0	2.0753346	1.9772706	THBS1
595	positive regulation of steroid metabolic process (GO:0045940)	1/23	0.3856798	1	0	0	2.0753346	1.9772706	CYP17A1
596	cartilage condensation (GO:0001502)	1/23	0.3856798	1	0	0	2.0753346	1.9772706	CHAD
597	steroid metabolic process (GO:0008202)	6/240	0.3890023	1	0	0	1.1933174	1.1266944	HSD11B2;SLCO1B3;TFCP2L1;APOB;CYP3A5;CYP17A1
598	central nervous system development (GO:0007417)	3/108	0.3949304	1	0	0	1.3259082	1.2318294	SNTG2;ZBTB16;PAX6
599	inorganic anion transmembrane transport (GO:0098661)	3/108	0.3949304	1	0	0	1.3259082	1.2318294	ANO1;SLC26A2;ANO7
600	steroid biosynthetic process (GO:0006694)	3/108	0.3949304	1	0	0	1.3259082	1.2318294	HSD11B2;TFCP2L1;CYP17A1
601	regulation of neural precursor cell proliferation (GO:2000177)	2/65	0.3964187	1	0	0	1.4686984	1.3589636	SIX3;PAX6
602	trabecula formation (GO:0060343)	1/24	0.3985646	1	0	0	1.9888624	1.8295261	FBN2
603	regulation of cell aging (GO:0090342)	1/24	0.3985646	1	0	0	1.9888624	1.8295261	NEK6
604	regulation of epidermal growth factor-activated receptor activity (GO:0007176)	1/24	0.3985646	1	0	0	1.9888624	1.8295261	ADRA2A
605	phospholipid catabolic process (GO:0009395)	1/24	0.3985646	1	0	0	1.9888624	1.8295261	LIPG
606	embryonic hemopoiesis (GO:0035162)	1/24	0.3985646	1	0	0	1.9888624	1.8295261	TPO
607	regulation of actin cytoskeleton reorganization (GO:2000249)	1/24	0.3985646	1	0	0	1.9888624	1.8295261	CSF3
608	adrenal gland development (GO:0030325)	1/24	0.3985646	1	0	0	1.9888624	1.8295261	CYP17A1
609	negative regulation of adenylate cyclase activity (GO:0007194)	1/24	0.3985646	1	0	0	1.9888624	1.8295261	ADRA2A
610	positive regulation of blood coagulation (GO:0030194)	1/24	0.3985646	1	0	0	1.9888624	1.8295261	THBS1
611	sprouting angiogenesis (GO:0002040)	1/24	0.3985646	1	0	0	1.9888624	1.8295261	THBS1
612	bile acid and bile salt transport (GO:0015721)	1/24	0.3985646	1	0	0	1.9888624	1.8295261	SLCO1B3
613	endoderm development (GO:0007492)	1/24	0.3985646	1	0	0	1.9888624	1.8295261	PTHLH
614	cardiac ventricle morphogenesis (GO:0003208)	1/24	0.3985646	1	0	0	1.9888624	1.8295261	CPE
615	carbohydrate phosphorylation (GO:0046835)	1/24	0.3985646	1	0	0	1.9888624	1.8295261	HKDC1
616	protein import into nucleus, translocation (GO:0000060)	1/24	0.3985646	1	0	0	1.9888624	1.8295261	SIX3
617	positive regulation of hemostasis (GO:1900048)	1/24	0.3985646	1	0	0	1.9888624	1.8295261	THBS1
618	response to molecule of bacterial origin (GO:0002237)	6/243	0.4002119	1	0	0	1.1785851	1.0793025	CSF3;IRAK3;APOB;PTGS2;CXCL2;CYP17A1
619	cellular response to oxygen levels (GO:0071453)	3/109	0.4005788	1	0	0	1.3137440	1.2018719	STC1;PTGS2;NKX3-1
620	regulation of bone mineralization (GO:0030500)	2/66	0.4037913	1	0	0	1.4464454	1.3117193	FBN2;AHSG
621	dorsal/ventral pattern formation (GO:0009953)	2/66	0.4037913	1	0	0	1.4464454	1.3117193	SIX3;PAX6
622	multicellular organismal response to stress (GO:0033555)	2/66	0.4037913	1	0	0	1.4464454	1.3117193	THBS1;ADRA2A
623	digestion (GO:0007586)	2/66	0.4037913	1	0	0	1.4464454	1.3117193	ADM2;TFF1
624	negative regulation of epithelial cell proliferation (GO:0050680)	3/110	0.4062124	1	0	0	1.3018008	1.1727652	PAX6;THBS1;NKX3-1
625	vasculogenesis (GO:0001570)	2/67	0.4111207	1	0	0	1.4248566	1.2665099	NTRK2;TNNI3
626	regulation of myeloid leukocyte mediated immunity (GO:0002886)	1/25	0.4111798	1	0	0	1.9093079	1.6968492	ADORA3
627	negative regulation of signal transduction by p53 class mediator (GO:1901797)	1/25	0.4111798	1	0	0	1.9093079	1.6968492	MUC1
628	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage (GO:1902230)	1/25	0.4111798	1	0	0	1.9093079	1.6968492	MUC1
629	regulation of excretion (GO:0044062)	1/25	0.4111798	1	0	0	1.9093079	1.6968492	STC1
630	regulation of T cell mediated cytotoxicity (GO:0001914)	1/25	0.4111798	1	0	0	1.9093079	1.6968492	AZGP1
631	purinergic receptor signaling pathway (GO:0035587)	1/25	0.4111798	1	0	0	1.9093079	1.6968492	ADORA3
632	folic acid-containing compound metabolic process (GO:0006760)	1/25	0.4111798	1	0	0	1.9093079	1.6968492	ALDH1L2
633	negative regulation of cyclase activity (GO:0031280)	1/25	0.4111798	1	0	0	1.9093079	1.6968492	ADRA2A
634	response to iron ion (GO:0010039)	1/25	0.4111798	1	0	0	1.9093079	1.6968492	TFF1
635	positive regulation of cartilage development (GO:0061036)	1/25	0.4111798	1	0	0	1.9093079	1.6968492	ZBTB16
636	positive regulation of calcium-mediated signaling (GO:0050850)	1/25	0.4111798	1	0	0	1.9093079	1.6968492	ADORA3
637	regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)	1/25	0.4111798	1	0	0	1.9093079	1.6968492	JPH2
638	pancreas development (GO:0031016)	1/25	0.4111798	1	0	0	1.9093079	1.6968492	MSLN
639	negative regulation of cell-matrix adhesion (GO:0001953)	1/25	0.4111798	1	0	0	1.9093079	1.6968492	THBS1
640	regulation of leukocyte degranulation (GO:0043300)	1/25	0.4111798	1	0	0	1.9093079	1.6968492	ADORA3
641	positive regulation of synapse assembly (GO:0051965)	1/25	0.4111798	1	0	0	1.9093079	1.6968492	CUX2
642	response to lithium ion (GO:0010226)	1/25	0.4111798	1	0	0	1.9093079	1.6968492	PTGS2
643	detection of mechanical stimulus involved in sensory perception (GO:0050974)	1/25	0.4111798	1	0	0	1.9093079	1.6968492	PCDH15
644	fatty acid biosynthetic process (GO:0006633)	3/111	0.4118303	1	0	0	1.2900729	1.1444802	EDN2;PTGS2;ALOX15B
645	response to retinoic acid (GO:0032526)	3/111	0.4118303	1	0	0	1.2900729	1.1444802	MUC1;BRINP1;CYP17A1
646	positive regulation of response to external stimulus (GO:0032103)	5/201	0.4129169	1	0	0	1.1873805	1.0502486	CCL24;EDN2;ADORA3;PTGS2;THBS1
647	xenobiotic metabolic process (GO:0006805)	4/156	0.4134666	1	0	0	1.2239153	1.0809356	SULT1C2;SLC26A2;CYP3A5;CYP17A1
648	positive regulation of secretion by cell (GO:1903532)	6/247	0.4151390	1	0	0	1.1594987	1.0193640	C1QTNF1;ADORA3;DOC2B;ALOX15B;STXBP5L;NKX3-1
649	regulation of leukocyte chemotaxis (GO:0002688)	2/68	0.4184056	1	0	0	1.4039028	1.2232262	EDN2;THBS1
650	regulation of lipid biosynthetic process (GO:0046890)	3/113	0.4230156	1	0	0	1.2672397	1.0902650	APOB;PTGS2;CYP17A1
651	positive regulation of acute inflammatory response (GO:0002675)	1/26	0.4235310	1	0	0	1.8358730	1.5772510	PTGS2
652	positive regulation of coagulation (GO:0050820)	1/26	0.4235310	1	0	0	1.8358730	1.5772510	THBS1
653	regulation of the force of heart contraction (GO:0002026)	1/26	0.4235310	1	0	0	1.8358730	1.5772510	EDN2
654	positive regulation of heart contraction (GO:0045823)	1/26	0.4235310	1	0	0	1.8358730	1.5772510	EDN2
655	negative regulation of insulin receptor signaling pathway (GO:0046627)	1/26	0.4235310	1	0	0	1.8358730	1.5772510	AHSG
656	stem cell division (GO:0017145)	1/26	0.4235310	1	0	0	1.8358730	1.5772510	ZBTB16
657	macrophage activation (GO:0042116)	1/26	0.4235310	1	0	0	1.8358730	1.5772510	EDN2
658	positive regulation of vasoconstriction (GO:0045907)	1/26	0.4235310	1	0	0	1.8358730	1.5772510	PTGS2
659	positive regulation of vasodilation (GO:0045909)	1/26	0.4235310	1	0	0	1.8358730	1.5772510	ADRA2A
660	regulation of calcium ion import (GO:0090279)	1/26	0.4235310	1	0	0	1.8358730	1.5772510	STC1
661	positive regulation of cation channel activity (GO:2001259)	1/26	0.4235310	1	0	0	1.8358730	1.5772510	JPH2
662	positive regulation of membrane potential (GO:0045838)	1/26	0.4235310	1	0	0	1.8358730	1.5772510	CUX2
663	prostate gland epithelium morphogenesis (GO:0060740)	1/26	0.4235310	1	0	0	1.8358730	1.5772510	NKX3-1
664	negative regulation of lyase activity (GO:0051350)	1/26	0.4235310	1	0	0	1.8358730	1.5772510	ADRA2A
665	positive regulation of epidermis development (GO:0045684)	1/26	0.4235310	1	0	0	1.8358730	1.5772510	ALOX15B
666	regulation of blood circulation (GO:1903522)	5/204	0.4253023	1	0	0	1.1699190	1.0002283	EDN2;ADORA3;STC1;PTGS2;ADRA2A
667	positive regulation of muscle cell differentiation (GO:0051149)	2/70	0.4328361	1	0	0	1.3637913	1.1420335	CDH15;MYLK3
668	negative regulation of cell adhesion (GO:0007162)	3/115	0.4341277	1	0	0	1.2452008	1.0390162	ADAMDEC1;C1QTNF1;THBS1
669	learning (GO:0007612)	3/115	0.4341277	1	0	0	1.2452008	1.0390162	NTRK2;SLC6A1;PTGS2
670	regulation of vascular permeability (GO:0043114)	1/27	0.4356237	1	0	0	1.7678777	1.4690648	MYLK3
671	temperature homeostasis (GO:0001659)	1/27	0.4356237	1	0	0	1.7678777	1.4690648	EDN2
672	cardiac chamber morphogenesis (GO:0003206)	1/27	0.4356237	1	0	0	1.7678777	1.4690648	CPE
673	negative regulation of lipid transport (GO:0032369)	1/27	0.4356237	1	0	0	1.7678777	1.4690648	THBS1
674	regulation of vascular endothelial growth factor production (GO:0010574)	1/27	0.4356237	1	0	0	1.7678777	1.4690648	PTGS2
675	negative regulation of endothelial cell proliferation (GO:0001937)	1/27	0.4356237	1	0	0	1.7678777	1.4690648	THBS1
676	sarcomere organization (GO:0045214)	1/27	0.4356237	1	0	0	1.7678777	1.4690648	MYLK3
677	cellular response to fatty acid (GO:0071398)	1/27	0.4356237	1	0	0	1.7678777	1.4690648	APOB
678	response to gonadotropin (GO:0034698)	1/27	0.4356237	1	0	0	1.7678777	1.4690648	CYP17A1
679	developmental induction (GO:0031128)	1/27	0.4356237	1	0	0	1.7678777	1.4690648	SIX3
680	regulation of mast cell activation (GO:0033003)	1/27	0.4356237	1	0	0	1.7678777	1.4690648	ADORA3
681	regulation of platelet activation (GO:0010543)	1/27	0.4356237	1	0	0	1.7678777	1.4690648	C1QTNF1
682	neuron migration (GO:0001764)	3/116	0.4396542	1	0	0	1.2344663	1.0144433	NTRK2;PAX6;FEZF1
683	skeletal system development (GO:0001501)	4/162	0.4415524	1	0	0	1.1785851	0.9634445	COMP;AHSG;ZBTB16;PTHLH
684	regulation of response to wounding (GO:1903034)	8/347	0.4421392	1	0	0	1.1004656	0.8981235	CCL24;C1QTNF1;AHSG;ADORA3;PLAT;PTGS2;THBS1;ADRA2A
685	positive regulation of ion transmembrane transport (GO:0034767)	2/72	0.4470730	1	0	0	1.3259082	1.0674003	JPH2;STC1
686	regulation of biomineral tissue development (GO:0070167)	2/72	0.4470730	1	0	0	1.3259082	1.0674003	FBN2;AHSG
687	fear response (GO:0042596)	1/28	0.4474633	1	0	0	1.7047392	1.3708842	ADRA2A
688	long-term memory (GO:0007616)	1/28	0.4474633	1	0	0	1.7047392	1.3708842	NTRK2
689	glycerolipid catabolic process (GO:0046503)	1/28	0.4474633	1	0	0	1.7047392	1.3708842	APOB
690	dopamine metabolic process (GO:0042417)	1/28	0.4474633	1	0	0	1.7047392	1.3708842	GPR37
691	positive regulation of fatty acid metabolic process (GO:0045923)	1/28	0.4474633	1	0	0	1.7047392	1.3708842	PTGS2
692	cell-cell signaling involved in cell fate commitment (GO:0045168)	1/28	0.4474633	1	0	0	1.7047392	1.3708842	SIX3
693	cellular senescence (GO:0090398)	1/28	0.4474633	1	0	0	1.7047392	1.3708842	WNT16
694	negative regulation of innate immune response (GO:0045824)	1/28	0.4474633	1	0	0	1.7047392	1.3708842	IRAK3
695	negative regulation of cellular response to insulin stimulus (GO:1900077)	1/28	0.4474633	1	0	0	1.7047392	1.3708842	AHSG
696	epithelial cell differentiation (GO:0030855)	7/303	0.4503696	1	0	0	1.1027356	0.8796375	MUC1;CDSN;SIX3;PAX6;WNT16;PTHLH;SPDEF
697	cell maturation (GO:0048469)	3/118	0.4506445	1	0	0	1.2135431	0.9672867	SIX3;BHLHA15;TFCP2L1
698	post-translational protein modification (GO:0043687)	5/211	0.4539912	1	0	0	1.1311066	0.8932095	MUC1;B3GNT6;MUC3A;MUC5AC;MUC6
699	regulation of transcription factor import into nucleus (GO:0042990)	2/73	0.4541161	1	0	0	1.3077451	1.0323371	CSF3;PTGS2
700	epithelial cell proliferation (GO:0050673)	2/73	0.4541161	1	0	0	1.3077451	1.0323371	WNT16;NKX3-1
701	cellular response to heat (GO:0034605)	1/29	0.4590552	1	0	0	1.6459551	1.2815157	THBS1
702	regulation of fibroblast growth factor receptor signaling pathway (GO:0040036)	1/29	0.4590552	1	0	0	1.6459551	1.2815157	THBS1
703	lung epithelial cell differentiation (GO:0060487)	1/29	0.4590552	1	0	0	1.6459551	1.2815157	SPDEF
704	vitamin transport (GO:0051180)	1/29	0.4590552	1	0	0	1.6459551	1.2815157	TCN1
705	regulation of fatty acid biosynthetic process (GO:0042304)	1/29	0.4590552	1	0	0	1.6459551	1.2815157	PTGS2
706	non-canonical Wnt signaling pathway (GO:0035567)	1/29	0.4590552	1	0	0	1.6459551	1.2815157	CTHRC1
707	blood vessel morphogenesis (GO:0048514)	2/74	0.4611076	1	0	0	1.2900729	0.9986763	APOB;THBS1
708	regulation of synaptic plasticity (GO:0048167)	3/120	0.4615461	1	0	0	1.1933174	0.9226411	NTRK2;PLAT;PTGS2
709	response to vitamin (GO:0033273)	2/75	0.4680465	1	0	0	1.2728719	0.9663487	STC1;PTGS2
710	platelet-derived growth factor receptor signaling pathway (GO:0048008)	1/30	0.4704044	1	0	0	1.5910899	1.1999403	PLAT
711	positive regulation of multicellular organismal metabolic process (GO:0044253)	1/30	0.4704044	1	0	0	1.5910899	1.1999403	BMP8A
712	regulation of hormone metabolic process (GO:0032350)	1/30	0.4704044	1	0	0	1.5910899	1.1999403	CYP17A1
713	embryonic hindlimb morphogenesis (GO:0035116)	1/30	0.4704044	1	0	0	1.5910899	1.1999403	ZBTB16
714	central nervous system neuron development (GO:0021954)	1/30	0.4704044	1	0	0	1.5910899	1.1999403	NTRK2
715	long-term synaptic potentiation (GO:0060291)	1/30	0.4704044	1	0	0	1.5910899	1.1999403	NTRK2
716	regulation of regulated secretory pathway (GO:1903305)	1/30	0.4704044	1	0	0	1.5910899	1.1999403	ADORA3
717	positive regulation of receptor activity (GO:2000273)	1/30	0.4704044	1	0	0	1.5910899	1.1999403	ADRA2A
718	circadian behavior (GO:0048512)	1/30	0.4704044	1	0	0	1.5910899	1.1999403	SIX3
719	regulation of granulocyte chemotaxis (GO:0071622)	1/30	0.4704044	1	0	0	1.5910899	1.1999403	THBS1
720	endochondral ossification (GO:0001958)	1/30	0.4704044	1	0	0	1.5910899	1.1999403	PTHLH
721	lung cell differentiation (GO:0060479)	1/30	0.4704044	1	0	0	1.5910899	1.1999403	SPDEF
722	vasoconstriction (GO:0042310)	1/30	0.4704044	1	0	0	1.5910899	1.1999403	EDN2
723	photoreceptor cell maintenance (GO:0045494)	1/30	0.4704044	1	0	0	1.5910899	1.1999403	PCDH15
724	replacement ossification (GO:0036075)	1/30	0.4704044	1	0	0	1.5910899	1.1999403	PTHLH
725	regulation of muscle cell differentiation (GO:0051147)	3/122	0.4723536	1	0	0	1.1737548	0.8803484	CEACAM5;CDH15;MYLK3
726	positive regulation of protein complex assembly (GO:0031334)	3/122	0.4723536	1	0	0	1.1737548	0.8803484	CCL24;CSF3;CDC42EP5
727	regulation of actin polymerization or depolymerization (GO:0008064)	3/122	0.4723536	1	0	0	1.1737548	0.8803484	CCL24;CSF3;CDC42EP5
728	myeloid leukocyte migration (GO:0097529)	2/76	0.4749320	1	0	0	1.2561236	0.9352892	CCL24;EDN2
729	regulation of actin filament length (GO:0030832)	3/123	0.4777203	1	0	0	1.1642121	0.8600382	CCL24;CSF3;CDC42EP5
730	regulation of endothelial cell apoptotic process (GO:2000351)	1/31	0.4815161	1	0	0	1.5397644	1.1252839	THBS1
731	phenol-containing compound biosynthetic process (GO:0046189)	1/31	0.4815161	1	0	0	1.5397644	1.1252839	GPR37
732	cellular response to glucocorticoid stimulus (GO:0071385)	1/31	0.4815161	1	0	0	1.5397644	1.1252839	STC1
733	protein kinase B signaling (GO:0043491)	1/31	0.4815161	1	0	0	1.5397644	1.1252839	NKX3-1
734	regulation of mitochondrial membrane potential (GO:0051881)	1/31	0.4815161	1	0	0	1.5397644	1.1252839	PYCR1
735	positive regulation of blood pressure (GO:0045777)	1/31	0.4815161	1	0	0	1.5397644	1.1252839	HSD11B2
736	negative regulation of interleukin-6 production (GO:0032715)	1/31	0.4815161	1	0	0	1.5397644	1.1252839	IRAK3
737	peptide cross-linking (GO:0018149)	1/31	0.4815161	1	0	0	1.5397644	1.1252839	THBS1
738	regulation of steroid metabolic process (GO:0019218)	2/77	0.4817632	1	0	0	1.2398103	0.9054366	APOB;CYP17A1
739	positive regulation of transmembrane transport (GO:0034764)	2/77	0.4817632	1	0	0	1.2398103	0.9054366	JPH2;STC1
740	regulation of calcium ion transport (GO:0051924)	4/171	0.4828810	1	0	0	1.1165543	0.8128349	JPH2;STC1;PTGS2;ADRA2A
741	signal release (GO:0023061)	3/124	0.4830616	1	0	0	1.1548233	0.8402623	ADORA3;DOC2B;SLC6A1
742	anion transmembrane transport (GO:0098656)	4/172	0.4874009	1	0	0	1.1100627	0.7977670	ANO1;SLC26A2;ANO7;SLC13A5
743	positive regulation of leukocyte mediated immunity (GO:0002705)	2/78	0.4885395	1	0	0	1.2239153	0.8767333	AZGP1;ADORA3
744	regulation of tumor necrosis factor production (GO:0032680)	2/78	0.4885395	1	0	0	1.2239153	0.8767333	IRAK3;THBS1
745	cellular response to lipid (GO:0071396)	7/315	0.4907568	1	0	0	1.0607266	0.7550323	CSF3;MUC1;BRINP1;STC1;APOB;CYP17A1;NKX3-1
746	regulation of ossification (GO:0030278)	4/173	0.4919047	1	0	0	1.1036462	0.7830041	FBN2;AHSG;ZBTB16;CTHRC1
747	pteridine-containing compound metabolic process (GO:0042558)	1/32	0.4923952	1	0	0	1.4916468	1.0567925	ALDH1L2
748	regulation of intrinsic apoptotic signaling pathway in response to DNA damage (GO:1902229)	1/32	0.4923952	1	0	0	1.4916468	1.0567925	MUC1
749	reproduction (GO:0000003)	1/32	0.4923952	1	0	0	1.4916468	1.0567925	CATSPERB
750	positive regulation of protein tyrosine kinase activity (GO:0061098)	1/32	0.4923952	1	0	0	1.4916468	1.0567925	ADRA2A
751	positive regulation of nitric oxide biosynthetic process (GO:0045429)	1/32	0.4923952	1	0	0	1.4916468	1.0567925	PTGS2
752	rhythmic behavior (GO:0007622)	1/32	0.4923952	1	0	0	1.4916468	1.0567925	SIX3
753	regulation of potassium ion transmembrane transport (GO:1901379)	1/32	0.4923952	1	0	0	1.4916468	1.0567925	KCNN2
754	brown fat cell differentiation (GO:0050873)	1/32	0.4923952	1	0	0	1.4916468	1.0567925	PTGS2
755	calcium ion import (GO:0070509)	1/32	0.4923952	1	0	0	1.4916468	1.0567925	CACNA1E
756	response to pain (GO:0048265)	1/32	0.4923952	1	0	0	1.4916468	1.0567925	THBS1
757	negative regulation of purine nucleotide catabolic process (GO:0033122)	1/32	0.4923952	1	0	0	1.4916468	1.0567925	TNNI3
758	androgen metabolic process (GO:0008209)	1/32	0.4923952	1	0	0	1.4916468	1.0567925	CYP17A1
759	one-carbon metabolic process (GO:0006730)	1/32	0.4923952	1	0	0	1.4916468	1.0567925	ALDH1L2
760	sulfur compound transport (GO:0072348)	1/32	0.4923952	1	0	0	1.4916468	1.0567925	SLC26A2
761	regulation of synaptic transmission, GABAergic (GO:0032228)	1/32	0.4923952	1	0	0	1.4916468	1.0567925	SLC6A1
762	regulation of intrinsic apoptotic signaling pathway (GO:2001242)	3/126	0.4936654	1	0	0	1.1364928	0.8022473	MUC1;IL19;NKX3-1
763	eye development (GO:0001654)	2/79	0.4952601	1	0	0	1.2084227	0.8491250	SIX3;PAX6
764	positive regulation of epithelial cell migration (GO:0010634)	2/79	0.4952601	1	0	0	1.2084227	0.8491250	PTGS2;THBS1
765	regulation of protein polymerization (GO:0032271)	3/127	0.4989268	1	0	0	1.1275440	0.7839768	CCL24;CSF3;CDC42EP5
766	inorganic anion transport (GO:0015698)	3/127	0.4989268	1	0	0	1.1275440	0.7839768	ANO1;SLC26A2;ANO7
767	positive regulation of protein import into nucleus (GO:0042307)	2/80	0.5019244	1	0	0	1.1933174	0.8225606	CSF3;PTGS2
768	regulation of tumor necrosis factor superfamily cytokine production (GO:1903555)	2/80	0.5019244	1	0	0	1.1933174	0.8225606	IRAK3;THBS1
769	positive regulation of reproductive process (GO:2000243)	1/33	0.5030465	1	0	0	1.4464454	0.9938131	PLAT
770	calcium ion-dependent exocytosis (GO:0017156)	1/33	0.5030465	1	0	0	1.4464454	0.9938131	SYT8
771	negative regulation of nucleotide catabolic process (GO:0030812)	1/33	0.5030465	1	0	0	1.4464454	0.9938131	TNNI3
772	peptide hormone processing (GO:0016486)	1/33	0.5030465	1	0	0	1.4464454	0.9938131	CPE
773	cellular response to corticosteroid stimulus (GO:0071384)	1/33	0.5030465	1	0	0	1.4464454	0.9938131	STC1
774	regulation of insulin secretion involved in cellular response to glucose stimulus (GO:0061178)	1/33	0.5030465	1	0	0	1.4464454	0.9938131	ADRA2A
775	response to progesterone (GO:0032570)	1/33	0.5030465	1	0	0	1.4464454	0.9938131	THBS1
776	transferrin transport (GO:0033572)	1/33	0.5030465	1	0	0	1.4464454	0.9938131	REP15
777	regulation of protein binding (GO:0043393)	3/128	0.5041604	1	0	0	1.1187351	0.7661777	CSF3;NKX3-1;CTHRC1
778	response to mechanical stimulus (GO:0009612)	4/176	0.5053159	1	0	0	1.0848340	0.7404767	NTRK2;PCDH15;PTGS2;THBS1
779	secretion by cell (GO:0032940)	9/415	0.5053996	1	0	0	1.0351669	0.7064041	NTRK2;SLC17A9;ADORA3;DOC2B;SLC6A1;SYT8;THBS1;F5;STXBP5L
780	platelet degranulation (GO:0002576)	2/81	0.5085318	1	0	0	1.1785851	0.7969918	THBS1;F5
781	regulation of epithelial cell migration (GO:0010632)	3/129	0.5093659	1	0	0	1.1100627	0.7488358	STC1;PTGS2;THBS1
782	negative regulation of reproductive process (GO:2000242)	1/34	0.5134749	1	0	0	1.4039028	0.9357774	NKX3-1
783	response to cocaine (GO:0042220)	1/34	0.5134749	1	0	0	1.4039028	0.9357774	SLC6A1
784	regulation of cholesterol transport (GO:0032374)	1/34	0.5134749	1	0	0	1.4039028	0.9357774	LIPG
785	regulation of sterol transport (GO:0032371)	1/34	0.5134749	1	0	0	1.4039028	0.9357774	LIPG
786	negative regulation of tumor necrosis factor production (GO:0032720)	1/34	0.5134749	1	0	0	1.4039028	0.9357774	IRAK3
787	positive regulation of T cell mediated immunity (GO:0002711)	1/34	0.5134749	1	0	0	1.4039028	0.9357774	AZGP1
788	neuron fate commitment (GO:0048663)	1/34	0.5134749	1	0	0	1.4039028	0.9357774	PAX6
789	neuromuscular junction development (GO:0007528)	1/34	0.5134749	1	0	0	1.4039028	0.9357774	NTRK2
790	G2 DNA damage checkpoint (GO:0031572)	1/34	0.5134749	1	0	0	1.4039028	0.9357774	NEK6
791	regulation of dendritic spine development (GO:0060998)	1/34	0.5134749	1	0	0	1.4039028	0.9357774	CUX2
792	positive regulation of bone mineralization (GO:0030501)	1/34	0.5134749	1	0	0	1.4039028	0.9357774	FBN2
793	response to alcohol (GO:0097305)	6/274	0.5139041	1	0	0	1.0452415	0.6958368	STC1;TFF1;SLC6A1;PTGS2;THBS1;NKX3-1
794	regulation of system process (GO:0044057)	8/371	0.5170404	1	0	0	1.0292765	0.6789460	C1QTNF1;EDN2;ADORA3;STC1;TNNI3;PTGS2;ADRA2A;NKX3-1
795	cognition (GO:0050890)	5/227	0.5178823	1	0	0	1.0513810	0.6918163	NTRK2;CUX2;CHRM1;SLC6A1;PTGS2
796	regulation of angiogenesis (GO:0045765)	4/179	0.5185687	1	0	0	1.0666524	0.7004524	CCL24;ADM2;PTGS2;THBS1
797	positive regulation of intracellular protein transport (GO:0090316)	3/131	0.5196902	1	0	0	1.0931152	0.7154685	CSF3;CHRM1;PTGS2
798	response to lipopolysaccharide (GO:0032496)	5/228	0.5217758	1	0	0	1.0467697	0.6809418	CSF3;IRAK3;APOB;PTGS2;CYP17A1
799	ferric iron transport (GO:0015682)	1/35	0.5236849	1	0	0	1.3637913	0.8821891	REP15
800	drug metabolic process (GO:0017144)	1/35	0.5236849	1	0	0	1.3637913	0.8821891	CYP3A5
801	positive regulation of neural precursor cell proliferation (GO:2000179)	1/35	0.5236849	1	0	0	1.3637913	0.8821891	PAX6
802	metanephros development (GO:0001656)	1/35	0.5236849	1	0	0	1.3637913	0.8821891	NKX3-1
803	negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)	1/35	0.5236849	1	0	0	1.3637913	0.8821891	IRAK3
804	negative regulation of ion transmembrane transporter activity (GO:0032413)	1/35	0.5236849	1	0	0	1.3637913	0.8821891	ADRA2A
805	positive regulation of phagocytosis (GO:0050766)	1/35	0.5236849	1	0	0	1.3637913	0.8821891	AHSG
806	positive regulation of alpha-beta T cell differentiation (GO:0046638)	1/35	0.5236849	1	0	0	1.3637913	0.8821891	ZBTB16
807	negative regulation of nucleoside metabolic process (GO:0045978)	1/35	0.5236849	1	0	0	1.3637913	0.8821891	TNNI3
808	glycoprotein biosynthetic process (GO:0009101)	1/35	0.5236849	1	0	0	1.3637913	0.8821891	B3GNT6
809	cAMP metabolic process (GO:0046058)	1/35	0.5236849	1	0	0	1.3637913	0.8821891	PTHLH
810	trivalent inorganic cation transport (GO:0072512)	1/35	0.5236849	1	0	0	1.3637913	0.8821891	REP15
811	hexose catabolic process (GO:0019320)	1/35	0.5236849	1	0	0	1.3637913	0.8821891	FUT6
812	protein trimerization (GO:0070206)	1/35	0.5236849	1	0	0	1.3637913	0.8821891	C1QTNF1
813	positive regulation of protein localization to nucleus (GO:1900182)	2/84	0.5280072	1	0	0	1.1364928	0.7258159	CSF3;PTGS2
814	chloride transmembrane transport (GO:1902476)	2/84	0.5280072	1	0	0	1.1364928	0.7258159	ANO1;ANO7
815	negative regulation of peptidase activity (GO:0010466)	5/230	0.5295221	1	0	0	1.0376673	0.6597285	SERPINB4;AHSG;HMSD;SSPO;THBS1
816	positive regulation of protein transport (GO:0051222)	5/231	0.5333744	1	0	0	1.0331753	0.6493833	CSF3;CHRM1;PTGS2;ALOX15B;STXBP5L
817	regulation of cell-substrate junction assembly (GO:0090109)	1/36	0.5336812	1	0	0	1.3259082	0.8326130	THBS1
818	detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)	1/36	0.5336812	1	0	0	1.3259082	0.8326130	AZGP1
819	regulation of insulin receptor signaling pathway (GO:0046626)	1/36	0.5336812	1	0	0	1.3259082	0.8326130	AHSG
820	regulation of histone acetylation (GO:0035065)	1/36	0.5336812	1	0	0	1.3259082	0.8326130	MUC1
821	regulation of focal adhesion assembly (GO:0051893)	1/36	0.5336812	1	0	0	1.3259082	0.8326130	THBS1
822	regulation of catecholamine secretion (GO:0050433)	1/36	0.5336812	1	0	0	1.3259082	0.8326130	ADRA2A
823	synaptic transmission, glutamatergic (GO:0035249)	1/36	0.5336812	1	0	0	1.3259082	0.8326130	PLAT
824	positive regulation of biomineral tissue development (GO:0070169)	1/36	0.5336812	1	0	0	1.3259082	0.8326130	FBN2
825	positive regulation of synaptic transmission (GO:0050806)	2/85	0.5343819	1	0	0	1.1231223	0.7037984	NTRK2;PTGS2
826	blood vessel development (GO:0001568)	2/85	0.5343819	1	0	0	1.1231223	0.7037984	PAX6;NKX3-1
827	regulation of striated muscle cell differentiation (GO:0051153)	2/85	0.5343819	1	0	0	1.1231223	0.7037984	CEACAM5;MYLK3
828	second-messenger-mediated signaling (GO:0019932)	3/134	0.5349533	1	0	0	1.0686425	0.6685170	NTRK2;EDN2;BHLHA15
829	positive regulation of cell migration (GO:0030335)	6/280	0.5350561	1	0	0	1.0228435	0.6396697	CCL24;EDN2;ADORA3;PTGS2;THBS1;ADRA2A
830	negative regulation of secretion by cell (GO:1903531)	3/135	0.5399797	1	0	0	1.0607266	0.6536449	BMP8A;ADRA2A;STXBP5L
831	regulation of reproductive process (GO:2000241)	2/86	0.5406975	1	0	0	1.1100627	0.6825724	PLAT;NKX3-1
832	embryonic limb morphogenesis (GO:0030326)	2/86	0.5406975	1	0	0	1.1100627	0.6825724	FBN2;ZBTB16
833	regulation of stem cell proliferation (GO:0072091)	2/86	0.5406975	1	0	0	1.1100627	0.6825724	SIX3;PAX6
834	long-chain fatty acid metabolic process (GO:0001676)	2/86	0.5406975	1	0	0	1.1100627	0.6825724	PTGS2;ALOX15B
835	vascular process in circulatory system (GO:0003018)	2/86	0.5406975	1	0	0	1.1100627	0.6825724	EDN2;MYLK3
836	embryonic appendage morphogenesis (GO:0035113)	2/86	0.5406975	1	0	0	1.1100627	0.6825724	FBN2;ZBTB16
837	exocytosis (GO:0006887)	5/233	0.5410362	1	0	0	1.0243068	0.6292000	SLC17A9;SYT8;THBS1;F5;STXBP5L
838	mitotic nuclear envelope disassembly (GO:0007077)	1/37	0.5434681	1	0	0	1.2900729	0.7866661	NEK6
839	regulation of epidermal cell differentiation (GO:0045604)	1/37	0.5434681	1	0	0	1.2900729	0.7866661	ALOX15B
840	positive regulation of leukocyte mediated cytotoxicity (GO:0001912)	1/37	0.5434681	1	0	0	1.2900729	0.7866661	AZGP1
841	regulation of toll-like receptor signaling pathway (GO:0034121)	1/37	0.5434681	1	0	0	1.2900729	0.7866661	IRAK3
842	regulation of adherens junction organization (GO:1903391)	1/37	0.5434681	1	0	0	1.2900729	0.7866661	THBS1
843	feeding behavior (GO:0007631)	2/87	0.5469535	1	0	0	1.0973034	0.6621035	NTRK2;ADM2
844	regulation of fat cell differentiation (GO:0045598)	2/87	0.5469535	1	0	0	1.0973034	0.6621035	ZBTB16;PTGS2
845	dicarboxylic acid metabolic process (GO:0043648)	2/87	0.5469535	1	0	0	1.0973034	0.6621035	ALDH1L2;CYP17A1
846	adult walking behavior (GO:0007628)	1/38	0.5530502	1	0	0	1.2561236	0.7440102	PCDH15
847	epithelial cell morphogenesis (GO:0003382)	1/38	0.5530502	1	0	0	1.2561236	0.7440102	STC1
848	muscle filament sliding (GO:0030049)	1/38	0.5530502	1	0	0	1.2561236	0.7440102	TNNI3
849	protein kinase C-activating G-protein coupled receptor signaling pathway (GO:0007205)	1/38	0.5530502	1	0	0	1.2561236	0.7440102	CHRM1
850	membrane depolarization during action potential (GO:0086010)	1/38	0.5530502	1	0	0	1.2561236	0.7440102	CACNA1E
851	hindlimb morphogenesis (GO:0035137)	1/38	0.5530502	1	0	0	1.2561236	0.7440102	ZBTB16
852	anion homeostasis (GO:0055081)	1/38	0.5530502	1	0	0	1.2561236	0.7440102	LIPG
853	regulation of calcium-mediated signaling (GO:0050848)	1/38	0.5530502	1	0	0	1.2561236	0.7440102	ADORA3
854	regulation of lipid storage (GO:0010883)	1/38	0.5530502	1	0	0	1.2561236	0.7440102	APOB
855	ventricular cardiac muscle tissue morphogenesis (GO:0055010)	1/38	0.5530502	1	0	0	1.2561236	0.7440102	TNNI3
856	positive regulation of oxidoreductase activity (GO:0051353)	1/38	0.5530502	1	0	0	1.2561236	0.7440102	EDN2
857	actin-myosin filament sliding (GO:0033275)	1/38	0.5530502	1	0	0	1.2561236	0.7440102	TNNI3
858	positive regulation of reactive oxygen species metabolic process (GO:2000379)	1/38	0.5530502	1	0	0	1.2561236	0.7440102	THBS1
859	regulation of endothelial cell proliferation (GO:0001936)	2/88	0.5531498	1	0	0	1.0848340	0.6423590	CCL24;THBS1
860	pattern specification process (GO:0007389)	8/385	0.5591631	1	0	0	0.9918482	0.5765754	LEFTY1;DAAM2;ZBTB16;SIX3;STC1;PAX6;FEZF1;NKX3-1
861	positive regulation of cell motility (GO:2000147)	6/287	0.5592308	1	0	0	0.9978961	0.5799703	CCL24;EDN2;ADORA3;PTGS2;THBS1;ADRA2A
862	cellular response to reactive oxygen species (GO:0034614)	2/89	0.5592860	1	0	0	1.0726449	0.6233079	TPO;PXDN
863	regulation of dendrite development (GO:0050773)	2/89	0.5592860	1	0	0	1.0726449	0.6233079	NTRK2;CUX2
864	heart morphogenesis (GO:0003007)	1/39	0.5624316	1	0	0	1.2239153	0.7043459	LEFTY1
865	regulation of multicellular organismal metabolic process (GO:0044246)	1/39	0.5624316	1	0	0	1.2239153	0.7043459	BMP8A
866	retina homeostasis (GO:0001895)	1/39	0.5624316	1	0	0	1.2239153	0.7043459	AZGP1
867	bile acid metabolic process (GO:0008206)	1/39	0.5624316	1	0	0	1.2239153	0.7043459	SLCO1B3
868	positive regulation of dendrite development (GO:1900006)	1/39	0.5624316	1	0	0	1.2239153	0.7043459	CUX2
869	endocrine pancreas development (GO:0031018)	1/39	0.5624316	1	0	0	1.2239153	0.7043459	FOXA3
870	positive regulation of striated muscle cell differentiation (GO:0051155)	1/39	0.5624316	1	0	0	1.2239153	0.7043459	MYLK3
871	phagosome maturation (GO:0090382)	1/39	0.5624316	1	0	0	1.2239153	0.7043459	RAB43
872	membrane disassembly (GO:0030397)	1/39	0.5624316	1	0	0	1.2239153	0.7043459	NEK6
873	hippocampus development (GO:0021766)	1/39	0.5624316	1	0	0	1.2239153	0.7043459	CYP17A1
874	regulation of NF-kappaB import into nucleus (GO:0042345)	1/39	0.5624316	1	0	0	1.2239153	0.7043459	PTGS2
875	detection of mechanical stimulus (GO:0050982)	1/39	0.5624316	1	0	0	1.2239153	0.7043459	PCDH15
876	acute-phase response (GO:0006953)	1/39	0.5624316	1	0	0	1.2239153	0.7043459	AHSG
877	nuclear envelope disassembly (GO:0051081)	1/39	0.5624316	1	0	0	1.2239153	0.7043459	NEK6
878	bone mineralization (GO:0030282)	1/39	0.5624316	1	0	0	1.2239153	0.7043459	PTGS2
879	negative regulation of blood pressure (GO:0045776)	1/39	0.5624316	1	0	0	1.2239153	0.7043459	ADM2
880	regulation of vasodilation (GO:0042312)	1/39	0.5624316	1	0	0	1.2239153	0.7043459	ADRA2A
881	spindle assembly (GO:0051225)	1/39	0.5624316	1	0	0	1.2239153	0.7043459	NEK6
882	neurogenesis (GO:0022008)	1/39	0.5624316	1	0	0	1.2239153	0.7043459	OMP
883	regulation of heart contraction (GO:0008016)	3/140	0.5646363	1	0	0	1.0228435	0.5846303	EDN2;ADORA3;STC1
884	positive regulation of chemotaxis (GO:0050921)	2/90	0.5653620	1	0	0	1.0607266	0.6049208	EDN2;THBS1
885	regulation of neurotransmitter levels (GO:0001505)	2/90	0.5653620	1	0	0	1.0607266	0.6049208	DOC2B;SLC6A1
886	positive regulation of calcium ion transport (GO:0051928)	2/91	0.5713775	1	0	0	1.0490703	0.5871700	JPH2;STC1
887	regulation of peptidyl-lysine acetylation (GO:2000756)	1/40	0.5716165	1	0	0	1.1933174	0.6674069	MUC1
888	monosaccharide catabolic process (GO:0046365)	1/40	0.5716165	1	0	0	1.1933174	0.6674069	FUT6
889	forelimb morphogenesis (GO:0035136)	1/40	0.5716165	1	0	0	1.1933174	0.6674069	ZBTB16
890	blood circulation (GO:0008015)	1/40	0.5716165	1	0	0	1.1933174	0.6674069	F5
891	outflow tract morphogenesis (GO:0003151)	1/40	0.5716165	1	0	0	1.1933174	0.6674069	THBS1
892	glutamate receptor signaling pathway (GO:0007215)	1/40	0.5716165	1	0	0	1.1933174	0.6674069	GRM8
893	response to nutrient levels (GO:0031667)	6/291	0.5727788	1	0	0	0.9841793	0.5484395	HSD11B2;LIPG;STC1;PTGS2;FOXA3;CYP17A1
894	chloride transport (GO:0006821)	2/92	0.5773325	1	0	0	1.0376673	0.5700289	ANO1;ANO7
895	negative regulation of cell-cell adhesion (GO:0022408)	1/41	0.5806091	1	0	0	1.1642121	0.6329560	C1QTNF1
896	regulation of transcription from RNA polymerase II promoter in response to stress (GO:0043618)	1/41	0.5806091	1	0	0	1.1642121	0.6329560	MUC1
897	positive regulation of chemokine production (GO:0032722)	1/41	0.5806091	1	0	0	1.1642121	0.6329560	ALOX15B
898	cardiac muscle contraction (GO:0060048)	1/41	0.5806091	1	0	0	1.1642121	0.6329560	TNNI3
899	regulation of alcohol biosynthetic process (GO:1902930)	1/41	0.5806091	1	0	0	1.1642121	0.6329560	APOB
900	somitogenesis (GO:0001756)	1/41	0.5806091	1	0	0	1.1642121	0.6329560	NKX3-1
901	protein peptidyl-prolyl isomerization (GO:0000413)	1/41	0.5806091	1	0	0	1.1642121	0.6329560	FKBP5
902	response to exogenous dsRNA (GO:0043330)	1/41	0.5806091	1	0	0	1.1642121	0.6329560	IRAK3
903	regulation of synapse assembly (GO:0051963)	1/41	0.5806091	1	0	0	1.1642121	0.6329560	CUX2
904	negative regulation of muscle cell differentiation (GO:0051148)	1/41	0.5806091	1	0	0	1.1642121	0.6329560	CEACAM5
905	positive regulation of binding (GO:0051099)	2/93	0.5832269	1	0	0	1.0265096	0.5534724	CSF3;CTHRC1
906	regulation of synaptic transmission (GO:0050804)	5/245	0.5857120	1	0	0	0.9741367	0.5210921	NTRK2;GRM8;PLAT;SLC6A1;PTGS2
907	visual perception (GO:0007601)	4/195	0.5862086	1	0	0	0.9791322	0.5229346	GRM8;SIX3;PCDH15;PAX6
908	positive regulation of nucleocytoplasmic transport (GO:0046824)	2/94	0.5890605	1	0	0	1.0155893	0.5374767	CSF3;PTGS2
909	negative regulation of cell-substrate adhesion (GO:0010812)	1/42	0.5894134	1	0	0	1.1364928	0.6007814	THBS1
910	regulation of ATPase activity (GO:0043462)	1/42	0.5894134	1	0	0	1.1364928	0.6007814	TNNI3
911	calcium ion transport into cytosol (GO:0060402)	1/42	0.5894134	1	0	0	1.1364928	0.6007814	JPH2
912	positive regulation of cell killing (GO:0031343)	1/42	0.5894134	1	0	0	1.1364928	0.6007814	AZGP1
913	negative regulation of response to DNA damage stimulus (GO:2001021)	1/42	0.5894134	1	0	0	1.1364928	0.6007814	MUC1
914	regulation of ATP catabolic process (GO:1903289)	1/42	0.5894134	1	0	0	1.1364928	0.6007814	TNNI3
915	regulation of alpha-beta T cell differentiation (GO:0046637)	1/42	0.5894134	1	0	0	1.1364928	0.6007814	ZBTB16
916	regulation of protein acetylation (GO:1901983)	1/42	0.5894134	1	0	0	1.1364928	0.6007814	MUC1
917	androgen receptor signaling pathway (GO:0030521)	1/42	0.5894134	1	0	0	1.1364928	0.6007814	NKX3-1
918	positive regulation of cellular component movement (GO:0051272)	6/296	0.5894219	1	0	0	0.9675547	0.5114620	CCL24;EDN2;ADORA3;PTGS2;THBS1;ADRA2A
919	regionalization (GO:0003002)	5/247	0.5929271	1	0	0	0.9662489	0.5050426	ZBTB16;SIX3;PAX6;FEZF1;NKX3-1
920	regulation of vasculature development (GO:1901342)	4/197	0.5942693	1	0	0	0.9691918	0.5043894	CCL24;ADM2;PTGS2;THBS1
921	response to hydrogen peroxide (GO:0042542)	2/95	0.5948333	1	0	0	1.0048989	0.5220190	TPO;PXDN
922	hemopoiesis (GO:0030097)	2/95	0.5948333	1	0	0	1.0048989	0.5220190	TPO;ZBTB16
923	regulation of cytokine-mediated signaling pathway (GO:0001959)	2/95	0.5948333	1	0	0	1.0048989	0.5220190	PXDN;IRAK3
924	cellular response to acid chemical (GO:0071229)	3/147	0.5977683	1	0	0	0.9741367	0.5012440	MUC1;BRINP1;APOB
925	detection of chemical stimulus involved in sensory perception of taste (GO:0050912)	1/43	0.5980332	1	0	0	1.1100627	0.5706932	AZGP1
926	cerebral cortex development (GO:0021987)	1/43	0.5980332	1	0	0	1.1100627	0.5706932	NTRK2
927	cellular response to cAMP (GO:0071320)	1/43	0.5980332	1	0	0	1.1100627	0.5706932	STC1
928	catecholamine metabolic process (GO:0006584)	1/43	0.5980332	1	0	0	1.1100627	0.5706932	GPR37
929	cytosolic calcium ion transport (GO:0060401)	1/43	0.5980332	1	0	0	1.1100627	0.5706932	JPH2
930	negative regulation of transporter activity (GO:0032410)	1/43	0.5980332	1	0	0	1.1100627	0.5706932	ADRA2A
931	catechol-containing compound metabolic process (GO:0009712)	1/43	0.5980332	1	0	0	1.1100627	0.5706932	GPR37
932	regulation of cardiac muscle contraction (GO:0055117)	1/43	0.5980332	1	0	0	1.1100627	0.5706932	STC1
933	sperm motility (GO:0030317)	1/43	0.5980332	1	0	0	1.1100627	0.5706932	APOB
934	learning or memory (GO:0007611)	4/198	0.5982647	1	0	0	0.9642969	0.4953806	NTRK2;CUX2;SLC6A1;PTGS2
935	sensory perception of light stimulus (GO:0050953)	4/198	0.5982647	1	0	0	0.9642969	0.4953806	GRM8;SIX3;PCDH15;PAX6
936	positive regulation of cellular component biogenesis (GO:0044089)	5/249	0.6000726	1	0	0	0.9584879	0.4895042	CCL24;CSF3;CUX2;CDC42EP5;MYLK3
937	lipid homeostasis (GO:0055088)	2/96	0.6005453	1	0	0	0.9944312	0.5070776	LIPG;APOB
938	regulation of metal ion transport (GO:0010959)	5/250	0.6036188	1	0	0	0.9546539	0.4819212	JPH2;STC1;KCNN2;PTGS2;ADRA2A
939	negative regulation of extrinsic apoptotic signaling pathway (GO:2001237)	2/97	0.6061965	1	0	0	0.9841793	0.4926321	IL19;THBS1
940	glycolytic process (GO:0006096)	1/44	0.6064726	1	0	0	1.0848340	0.5425209	HKDC1
941	regulation of mitotic metaphase/anaphase transition (GO:0030071)	1/44	0.6064726	1	0	0	1.0848340	0.5425209	NEK6
942	regulation of lipid catabolic process (GO:0050994)	1/44	0.6064726	1	0	0	1.0848340	0.5425209	ADRA2A
943	positive regulation of tumor necrosis factor production (GO:0032760)	1/44	0.6064726	1	0	0	1.0848340	0.5425209	THBS1
944	lipoprotein metabolic process (GO:0042157)	1/44	0.6064726	1	0	0	1.0848340	0.5425209	APOB
945	regulation of signal transduction by p53 class mediator (GO:1901796)	1/44	0.6064726	1	0	0	1.0848340	0.5425209	MUC1
946	regulation of nitric oxide biosynthetic process (GO:0045428)	1/44	0.6064726	1	0	0	1.0848340	0.5425209	PTGS2
947	regulation of leukocyte mediated cytotoxicity (GO:0001910)	1/44	0.6064726	1	0	0	1.0848340	0.5425209	AZGP1
948	segmentation (GO:0035282)	1/44	0.6064726	1	0	0	1.0848340	0.5425209	NKX3-1
949	cell fate determination (GO:0001709)	1/44	0.6064726	1	0	0	1.0848340	0.5425209	PAX6
950	protein transmembrane transport (GO:0071806)	1/44	0.6064726	1	0	0	1.0848340	0.5425209	AZGP1
951	multicellular organismal homeostasis (GO:0048871)	1/44	0.6064726	1	0	0	1.0848340	0.5425209	EDN2
952	neutrophil chemotaxis (GO:0030593)	1/44	0.6064726	1	0	0	1.0848340	0.5425209	EDN2
953	negative regulation of proteolysis (GO:0045861)	6/302	0.6089415	1	0	0	0.9483317	0.4704039	SERPINB4;AHSG;HMSD;SSPO;PLAT;THBS1
954	protein processing (GO:0016485)	4/201	0.6101088	1	0	0	0.9499044	0.4693648	CPE;PLAT;PTHLH;NKX3-1
955	actin filament bundle assembly (GO:0051017)	1/45	0.6147351	1	0	0	1.0607266	0.5161112	SHROOM1
956	eye morphogenesis (GO:0048592)	1/45	0.6147351	1	0	0	1.0607266	0.5161112	PAX6
957	regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902041)	1/45	0.6147351	1	0	0	1.0607266	0.5161112	THBS1
958	regulation of metaphase/anaphase transition of cell cycle (GO:1902099)	1/45	0.6147351	1	0	0	1.0607266	0.5161112	NEK6
959	response to antibiotic (GO:0046677)	1/45	0.6147351	1	0	0	1.0607266	0.5161112	CYP17A1
960	positive regulation of ion transmembrane transporter activity (GO:0032414)	1/45	0.6147351	1	0	0	1.0607266	0.5161112	JPH2
961	neutrophil migration (GO:1990266)	1/45	0.6147351	1	0	0	1.0607266	0.5161112	EDN2
962	regulation of cellular response to insulin stimulus (GO:1900076)	1/45	0.6147351	1	0	0	1.0607266	0.5161112	AHSG
963	actin filament bundle organization (GO:0061572)	1/45	0.6147351	1	0	0	1.0607266	0.5161112	SHROOM1
964	positive regulation of locomotion (GO:0040017)	6/304	0.6153339	1	0	0	0.9420927	0.4574711	CCL24;EDN2;ADORA3;PTGS2;THBS1;ADRA2A
965	neurotransmitter transport (GO:0006836)	2/99	0.6173166	1	0	0	0.9642969	0.4651511	DOC2B;SLC6A1
966	positive regulation of cytosolic calcium ion concentration (GO:0007204)	3/152	0.6204039	1	0	0	0.9420927	0.4497405	JPH2;C1QTNF1;EDN2
967	negative regulation of secretion (GO:0051048)	3/152	0.6204039	1	0	0	0.9420927	0.4497405	BMP8A;ADRA2A;STXBP5L
968	cell morphogenesis (GO:0000902)	4/204	0.6217366	1	0	0	0.9359352	0.4447927	STC1;TFCP2L1;SHROOM1;WNT16
969	cell-matrix adhesion (GO:0007160)	2/100	0.6227857	1	0	0	0.9546539	0.4520791	ITGA10;NID2
970	sensory perception of chemical stimulus (GO:0007606)	2/100	0.6227857	1	0	0	0.9546539	0.4520791	OMP;GRM8
971	response to calcium ion (GO:0051592)	2/100	0.6227857	1	0	0	0.9546539	0.4520791	SLC6A1;THBS1
972	leukocyte chemotaxis (GO:0030595)	2/100	0.6227857	1	0	0	0.9546539	0.4520791	CCL24;EDN2
973	fertilization (GO:0009566)	2/100	0.6227857	1	0	0	0.9546539	0.4520791	CATSPERB;APOB
974	regulation of T cell mediated immunity (GO:0002709)	1/46	0.6228246	1	0	0	1.0376673	0.4913255	AZGP1
975	regulation of DNA-templated transcription in response to stress (GO:0043620)	1/46	0.6228246	1	0	0	1.0376673	0.4913255	MUC1
976	positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)	1/46	0.6228246	1	0	0	1.0376673	0.4913255	THBS1
977	actin-mediated cell contraction (GO:0070252)	1/46	0.6228246	1	0	0	1.0376673	0.4913255	TNNI3
978	artery morphogenesis (GO:0048844)	1/46	0.6228246	1	0	0	1.0376673	0.4913255	APOB
979	positive regulation of smooth muscle cell proliferation (GO:0048661)	1/46	0.6228246	1	0	0	1.0376673	0.4913255	PTGS2
980	positive regulation of Rac GTPase activity (GO:0032855)	1/46	0.6228246	1	0	0	1.0376673	0.4913255	CCL24
981	platelet activation (GO:0030168)	4/205	0.6255638	1	0	0	0.9313697	0.4369073	ENTPD2;THBS1;ADRA2A;F5
982	regulation of actin filament-based process (GO:0032970)	5/257	0.6279339	1	0	0	0.9286517	0.4321205	CCL24;CSF3;CDC42EP5;STC1;MYLK3
983	transition metal ion transport (GO:0000041)	2/101	0.6281942	1	0	0	0.9452019	0.4394299	TCN1;REP15
984	regulation of response to cytokine stimulus (GO:0060759)	2/101	0.6281942	1	0	0	0.9452019	0.4394299	PXDN;IRAK3
985	limb morphogenesis (GO:0035108)	2/101	0.6281942	1	0	0	0.9452019	0.4394299	FBN2;ZBTB16
986	appendage morphogenesis (GO:0035107)	2/101	0.6281942	1	0	0	0.9452019	0.4394299	FBN2;ZBTB16
987	extracellular matrix organization (GO:0030198)	7/359	0.6287802	1	0	0	0.9307211	0.4318299	COMP;FBN2;ITGA10;PXDN;NID2;THBS1;MUC5AC
988	developmental maturation (GO:0021700)	3/154	0.6292124	1	0	0	0.9298577	0.4307904	SIX3;BHLHA15;TFCP2L1
989	chaperone-mediated protein folding (GO:0061077)	1/47	0.6307446	1	0	0	1.0155893	0.4680387	FKBP5
990	neural precursor cell proliferation (GO:0061351)	1/47	0.6307446	1	0	0	1.0155893	0.4680387	SIX3
991	smooth muscle contraction (GO:0006939)	1/47	0.6307446	1	0	0	1.0155893	0.4680387	EDN2
992	cellular response to UV (GO:0034644)	1/47	0.6307446	1	0	0	1.0155893	0.4680387	PTGS2
993	acid secretion (GO:0046717)	1/47	0.6307446	1	0	0	1.0155893	0.4680387	NTRK2
994	extracellular structure organization (GO:0043062)	7/360	0.6316703	1	0	0	0.9281358	0.4263742	COMP;FBN2;ITGA10;PXDN;NID2;THBS1;MUC5AC
995	organic hydroxy compound transport (GO:0015850)	2/102	0.6335424	1	0	0	0.9359352	0.4271873	LIPG;APOB
996	zymogen activation (GO:0031638)	2/102	0.6335424	1	0	0	0.9359352	0.4271873	PLAT;NKX3-1
997	cell chemotaxis (GO:0060326)	3/155	0.6335636	1	0	0	0.9238586	0.4216444	CCL24;EDN2;CXCL2
998	anatomical structure homeostasis (GO:0060249)	4/208	0.6368974	1	0	0	0.9179365	0.4141241	AZGP1;TFF1;PTHLH;MUC6
999	regulation of cardiac muscle tissue development (GO:0055024)	1/48	0.6384987	1	0	0	0.9944312	0.4461373	JPH2
1000	sperm-egg recognition (GO:0035036)	1/48	0.6384987	1	0	0	0.9944312	0.4461373	CATSPERB
1001	positive regulation of alpha-beta T cell activation (GO:0046635)	1/48	0.6384987	1	0	0	0.9944312	0.4461373	ZBTB16
1002	phospholipid transport (GO:0015914)	1/48	0.6384987	1	0	0	0.9944312	0.4461373	ATP10B
1003	phagocytosis (GO:0006909)	1/48	0.6384987	1	0	0	0.9944312	0.4461373	ELMOD1
1004	regulation of transforming growth factor beta receptor signaling pathway (GO:0017015)	2/103	0.6388304	1	0	0	0.9268485	0.4153359	FBN2;THBS1
1005	sensory organ development (GO:0007423)	2/103	0.6388304	1	0	0	0.9268485	0.4153359	SIX3;PAX6
1006	positive regulation of lipid metabolic process (GO:0045834)	2/103	0.6388304	1	0	0	0.9268485	0.4153359	PTGS2;CYP17A1
1007	cellular calcium ion homeostasis (GO:0006874)	5/261	0.6414181	1	0	0	0.9144195	0.4060697	JPH2;C1QTNF1;EDN2;STC1;TNNI3
1008	response to extracellular stimulus (GO:0009991)	6/313	0.6433621	1	0	0	0.9150038	0.4035602	HSD11B2;LIPG;STC1;PTGS2;FOXA3;CYP17A1
1009	monocarboxylic acid transport (GO:0015718)	2/104	0.6440582	1	0	0	0.9179365	0.4038609	SLCO1B3;SLC6A1
1010	negative regulation of cellular response to growth factor stimulus (GO:0090288)	2/104	0.6440582	1	0	0	0.9179365	0.4038609	FBN2;THBS1
1011	cellular response to drug (GO:0035690)	1/49	0.6460903	1	0	0	0.9741367	0.4255184	NKX3-1
1012	regulation of cytokine production involved in immune response (GO:0002718)	1/49	0.6460903	1	0	0	0.9741367	0.4255184	IRAK3
1013	response to dsRNA (GO:0043331)	1/49	0.6460903	1	0	0	0.9741367	0.4255184	IRAK3
1014	regulation of ion transmembrane transport (GO:0034765)	6/314	0.6463999	1	0	0	0.9120897	0.3979785	JPH2;STC1;KCNN2;CACNA1E;THBS1;ADRA2A
1015	hormone metabolic process (GO:0042445)	3/158	0.6464036	1	0	0	0.9063170	0.3954544	TPO;CPE;CYP17A1
1016	response to ketone (GO:1901654)	2/105	0.6492262	1	0	0	0.9091942	0.3927483	THBS1;NKX3-1
1017	negative regulation of protein processing (GO:0010955)	6/316	0.6524286	1	0	0	0.9063170	0.3870459	SERPINB4;AHSG;HMSD;SSPO;PLAT;THBS1
1018	negative regulation of protein maturation (GO:1903318)	6/316	0.6524286	1	0	0	0.9063170	0.3870459	SERPINB4;AHSG;HMSD;SSPO;PLAT;THBS1
1019	cardiac muscle tissue morphogenesis (GO:0055008)	1/50	0.6535229	1	0	0	0.9546539	0.4060885	TNNI3
1020	epithelial to mesenchymal transition (GO:0001837)	1/50	0.6535229	1	0	0	0.9546539	0.4060885	WNT16
1021	sensory perception of pain (GO:0019233)	1/50	0.6535229	1	0	0	0.9546539	0.4060885	PTGS2
1022	negative regulation of protein binding (GO:0032091)	1/50	0.6535229	1	0	0	0.9546539	0.4060885	NKX3-1
1023	regulation of cell killing (GO:0031341)	1/50	0.6535229	1	0	0	0.9546539	0.4060885	AZGP1
1024	regulation of cell junction assembly (GO:1901888)	1/50	0.6535229	1	0	0	0.9546539	0.4060885	THBS1
1025	regulation of osteoblast differentiation (GO:0045667)	2/106	0.6543346	1	0	0	0.9006169	0.3819845	FBN2;CTHRC1
1026	membrane depolarization (GO:0051899)	2/106	0.6543346	1	0	0	0.9006169	0.3819845	CUX2;CACNA1E
1027	positive regulation of protein secretion (GO:0050714)	2/106	0.6543346	1	0	0	0.9006169	0.3819845	ALOX15B;STXBP5L
1028	epithelial cell development (GO:0002064)	2/107	0.6593834	1	0	0	0.8921999	0.3715567	PAX6;SPDEF
1029	positive regulation of behavior (GO:0048520)	2/107	0.6593834	1	0	0	0.8921999	0.3715567	EDN2;THBS1
1030	response to inorganic substance (GO:0010035)	7/370	0.6598612	1	0	0	0.9030510	0.3754215	TPO;PXDN;TFF1;APOB;SLC6A1;PTGS2;THBS1
1031	positive regulation of insulin secretion (GO:0032024)	1/51	0.6607998	1	0	0	0.9359352	0.3877621	DOC2B
1032	regulation of neurotransmitter secretion (GO:0046928)	1/51	0.6607998	1	0	0	0.9359352	0.3877621	NTRK2
1033	positive regulation of axonogenesis (GO:0050772)	1/51	0.6607998	1	0	0	0.9359352	0.3877621	NTRK2
1034	response to nutrient (GO:0007584)	3/163	0.6670891	1	0	0	0.8785159	0.3556511	LIPG;STC1;PTGS2
1035	demethylation (GO:0070988)	1/52	0.6679242	1	0	0	0.9179365	0.3704614	CYP3A5
1036	positive regulation of transporter activity (GO:0032411)	1/52	0.6679242	1	0	0	0.9179365	0.3704614	JPH2
1037	regulation of excitatory postsynaptic membrane potential (GO:0060079)	1/52	0.6679242	1	0	0	0.9179365	0.3704614	CUX2
1038	regulation of phagocytosis (GO:0050764)	1/52	0.6679242	1	0	0	0.9179365	0.3704614	AHSG
1039	nuclear envelope organization (GO:0006998)	1/52	0.6679242	1	0	0	0.9179365	0.3704614	NEK6
1040	regulation of epithelial cell differentiation (GO:0030856)	2/109	0.6693038	1	0	0	0.8758293	0.3516605	PAX6;ALOX15B
1041	positive regulation of intracellular transport (GO:0032388)	4/217	0.6695431	1	0	0	0.8798654	0.3529666	CSF3;CHRM1;ADORA3;PTGS2
1042	positive regulation of neuron differentiation (GO:0045666)	4/217	0.6695431	1	0	0	0.8798654	0.3529666	NTRK2;CUX2;BRINP1;FEZF1
1043	cellular divalent inorganic cation homeostasis (GO:0072503)	5/271	0.6737754	1	0	0	0.8806771	0.3477428	JPH2;C1QTNF1;EDN2;STC1;TNNI3
1044	cellular response to lipopolysaccharide (GO:0071222)	2/110	0.6741759	1	0	0	0.8678672	0.3421690	CSF3;CYP17A1
1045	regulation of protein tyrosine kinase activity (GO:0061097)	1/53	0.6748993	1	0	0	0.9006169	0.3541152	ADRA2A
1046	regulation of epidermis development (GO:0045682)	1/53	0.6748993	1	0	0	0.9006169	0.3541152	ALOX15B
1047	regulation of cellular component size (GO:0032535)	3/165	0.6751126	1	0	0	0.8678672	0.3409640	CCL24;CSF3;CDC42EP5
1048	inflammatory response (GO:0006954)	7/376	0.6761377	1	0	0	0.8886406	0.3477771	CCL24;AHSG;ADORA3;PTGS2;CXCL2;THBS1;ADRA2A
1049	response to hexose (GO:0009746)	2/111	0.6789896	1	0	0	0.8600486	0.3329674	PTGS2;THBS1
1050	response to estrogen (GO:0043627)	3/166	0.6790707	1	0	0	0.8626391	0.3338672	TFF1;SLC6A1;PTGS2
1051	negative regulation of cell migration (GO:0030336)	3/166	0.6790707	1	0	0	0.8626391	0.3338672	STC1;ALOX15B;THBS1
1052	regulation of striated muscle contraction (GO:0006942)	1/54	0.6817282	1	0	0	0.8839388	0.3386584	STC1
1053	monocarboxylic acid biosynthetic process (GO:0072330)	3/167	0.6829931	1	0	0	0.8574736	0.3269295	EDN2;PTGS2;ALOX15B
1054	response to wounding (GO:0009611)	3/167	0.6829931	1	0	0	0.8574736	0.3269295	ADORA3;PLAT;PAX6
1055	calcium ion homeostasis (GO:0055074)	5/274	0.6830977	1	0	0	0.8710346	0.3319664	JPH2;C1QTNF1;EDN2;STC1;TNNI3
1056	regulation of cell shape (GO:0008360)	2/112	0.6837452	1	0	0	0.8523696	0.3240453	CCL24;CDC42EP5
1057	regulation of transmembrane transport (GO:0034762)	6/327	0.6844458	1	0	0	0.8758293	0.3320670	JPH2;STC1;KCNN2;CACNA1E;THBS1;ADRA2A
1058	response to acid chemical (GO:0001101)	5/275	0.6861652	1	0	0	0.8678672	0.3268708	MUC1;BRINP1;APOB;PTGS2;CYP17A1
1059	negative regulation of endopeptidase activity (GO:0010951)	4/222	0.6867877	1	0	0	0.8600486	0.3231461	SERPINB4;AHSG;HMSD;THBS1
1060	protein maturation (GO:0051604)	4/222	0.6867877	1	0	0	0.8600486	0.3231461	CPE;PLAT;PTHLH;NKX3-1
1061	positive regulation of apoptotic signaling pathway (GO:2001235)	3/168	0.6868797	1	0	0	0.8523696	0.3201467	IL19;THBS1;NKX3-1
1062	peptidyl-proline modification (GO:0018208)	1/55	0.6884140	1	0	0	0.8678672	0.3240311	FKBP5
1063	positive regulation of histone modification (GO:0031058)	1/55	0.6884140	1	0	0	0.8678672	0.3240311	MUC1
1064	embryonic digit morphogenesis (GO:0042733)	1/55	0.6884140	1	0	0	0.8678672	0.3240311	ZBTB16
1065	mesenchyme development (GO:0060485)	1/55	0.6884140	1	0	0	0.8678672	0.3240311	THBS1
1066	JNK cascade (GO:0007254)	1/55	0.6884140	1	0	0	0.8678672	0.3240311	CDC42EP5
1067	DNA duplex unwinding (GO:0032508)	1/55	0.6884140	1	0	0	0.8678672	0.3240311	RTEL1-TNFRSF6B
1068	single-organism carbohydrate catabolic process (GO:0044724)	2/113	0.6884430	1	0	0	0.8448265	0.3153930	FUT6;HKDC1
1069	carboxylic acid transport (GO:0046942)	4/224	0.6935057	1	0	0	0.8523696	0.3119638	NTRK2;SLCO1B3;SLC6A1;SLC13A5
1070	negative regulation of cell motility (GO:2000146)	3/170	0.6945459	1	0	0	0.8423417	0.3070311	STC1;ALOX15B;THBS1
1071	protein autophosphorylation (GO:0046777)	3/170	0.6945459	1	0	0	0.8423417	0.3070311	NTRK2;NEK6;IRAK3
1072	regulation of dendrite morphogenesis (GO:0048814)	1/56	0.6949597	1	0	0	0.8523696	0.3101785	CUX2
1073	positive regulation of chromatin modification (GO:1903310)	1/56	0.6949597	1	0	0	0.8523696	0.3101785	MUC1
1074	iron ion transport (GO:0006826)	1/56	0.6949597	1	0	0	0.8523696	0.3101785	REP15
1075	regulation of chemokine production (GO:0032642)	1/56	0.6949597	1	0	0	0.8523696	0.3101785	ALOX15B
1076	muscle tissue morphogenesis (GO:0060415)	1/56	0.6949597	1	0	0	0.8523696	0.3101785	TNNI3
1077	negative regulation of protein complex disassembly (GO:0043242)	1/56	0.6949597	1	0	0	0.8523696	0.3101785	IRAK3
1078	organic acid transport (GO:0015849)	4/226	0.7001206	1	0	0	0.8448265	0.3011829	NTRK2;SLCO1B3;SLC6A1;SLC13A5
1079	DNA geometric change (GO:0032392)	1/57	0.7013682	1	0	0	0.8374157	0.2970500	RTEL1-TNFRSF6B
1080	positive regulation of response to DNA damage stimulus (GO:2001022)	1/57	0.7013682	1	0	0	0.8374157	0.2970500	NKX3-1
1081	positive regulation of extrinsic apoptotic signaling pathway (GO:2001238)	1/57	0.7013682	1	0	0	0.8374157	0.2970500	THBS1
1082	homotypic cell-cell adhesion (GO:0034109)	1/57	0.7013682	1	0	0	0.8374157	0.2970500	CEACAM5
1083	actomyosin structure organization (GO:0031032)	1/57	0.7013682	1	0	0	0.8374157	0.2970500	MYLK3
1084	cell-cell recognition (GO:0009988)	1/57	0.7013682	1	0	0	0.8374157	0.2970500	CATSPERB
1085	regulation of myotube differentiation (GO:0010830)	1/57	0.7013682	1	0	0	0.8374157	0.2970500	CEACAM5
1086	response to monosaccharide (GO:0034284)	2/116	0.7021932	1	0	0	0.8229775	0.2909610	PTGS2;THBS1
1087	cellular response to molecule of bacterial origin (GO:0071219)	2/116	0.7021932	1	0	0	0.8229775	0.2909610	CSF3;CYP17A1
1088	embryonic pattern specification (GO:0009880)	1/58	0.7076424	1	0	0	0.8229775	0.2845991	ZBTB16
1089	regulation of postsynaptic membrane potential (GO:0060078)	1/58	0.7076424	1	0	0	0.8229775	0.2845991	CUX2
1090	neuron-neuron synaptic transmission (GO:0007270)	1/58	0.7076424	1	0	0	0.8229775	0.2845991	PLAT
1091	cyclic nucleotide metabolic process (GO:0009187)	1/58	0.7076424	1	0	0	0.8229775	0.2845991	PTHLH
1092	retina development in camera-type eye (GO:0060041)	1/58	0.7076424	1	0	0	0.8229775	0.2845991	PAX6
1093	regulation of hormone levels (GO:0010817)	4/229	0.7098499	1	0	0	0.8337589	0.2857306	TPO;ADORA3;CPE;CYP17A1
1094	positive regulation of neurogenesis (GO:0050769)	5/283	0.7099804	1	0	0	0.8433339	0.2888570	NTRK2;CUX2;BRINP1;PAX6;FEZF1
1095	anion transport (GO:0006820)	8/443	0.7134001	1	0	0	0.8619900	0.2911051	NTRK2;ANO1;SLC26A2;SLCO1B3;ATP10B;ANO7;SLC6A1;SLC13A5
1096	cellular ketone metabolic process (GO:0042180)	1/59	0.7137851	1	0	0	0.8090288	0.2727830	CYP17A1
1097	steroid hormone mediated signaling pathway (GO:0043401)	1/59	0.7137851	1	0	0	0.8090288	0.2727830	NKX3-1
1098	positive regulation of cytokine biosynthetic process (GO:0042108)	1/59	0.7137851	1	0	0	0.8090288	0.2727830	THBS1
1099	tetrapyrrole metabolic process (GO:0033013)	1/59	0.7137851	1	0	0	0.8090288	0.2727830	TCN1
1100	sterol metabolic process (GO:0016125)	2/119	0.7154359	1	0	0	0.8022302	0.2686374	APOB;CYP17A1
1101	cytosolic calcium ion homeostasis (GO:0051480)	3/176	0.7166933	1	0	0	0.8136255	0.2710246	JPH2;C1QTNF1;EDN2
1102	regulation of anatomical structure size (GO:0090066)	4/232	0.7193477	1	0	0	0.8229775	0.2710974	CCL24;CSF3;EDN2;CDC42EP5
1103	positive regulation of organelle organization (GO:0010638)	6/340	0.7197285	1	0	0	0.8423417	0.2770304	CCL24;CSF3;MUC1;CDC42EP5;DOC2B;MYLK3
1104	regulation of leukocyte mediated immunity (GO:0002703)	2/120	0.7197391	1	0	0	0.7955449	0.2616281	AZGP1;ADORA3
1105	epidermis development (GO:0008544)	2/120	0.7197391	1	0	0	0.7955449	0.2616281	CDSN;PTHLH
1106	regulation of chemotaxis (GO:0050920)	2/120	0.7197391	1	0	0	0.7955449	0.2616281	EDN2;THBS1
1107	carbohydrate catabolic process (GO:0016052)	2/120	0.7197391	1	0	0	0.7955449	0.2616281	FUT6;HKDC1
1108	single fertilization (GO:0007338)	1/60	0.7197990	1	0	0	0.7955449	0.2615619	CATSPERB
1109	neuron development (GO:0048666)	2/121	0.7239875	1	0	0	0.7889702	0.2548225	NTRK2;PAX6
1110	actin filament-based movement (GO:0030048)	1/61	0.7256868	1	0	0	0.7825032	0.2508993	TNNI3
1111	cell fate specification (GO:0001708)	1/61	0.7256868	1	0	0	0.7825032	0.2508993	PAX6
1112	secretion by tissue (GO:0032941)	1/61	0.7256868	1	0	0	0.7825032	0.2508993	CHRM1
1113	kidney development (GO:0001822)	2/122	0.7281814	1	0	0	0.7825032	0.2482140	ZBTB16;NKX3-1
1114	response to oxidative stress (GO:0006979)	5/290	0.7297575	1	0	0	0.8229775	0.2592733	TPO;PXDN;PYCR1;PTGS2;WNT16
1115	cell aging (GO:0007569)	1/62	0.7314513	1	0	0	0.7698822	0.2407612	WNT16
1116	negative regulation of G-protein coupled receptor protein signaling pathway (GO:0045744)	1/62	0.7314513	1	0	0	0.7698822	0.2407612	ADRA2A
1117	stem cell differentiation (GO:0048863)	1/62	0.7314513	1	0	0	0.7698822	0.2407612	SIX3
1118	regulation of cation channel activity (GO:2001257)	1/62	0.7314513	1	0	0	0.7698822	0.2407612	JPH2
1119	positive regulation of cell morphogenesis involved in differentiation (GO:0010770)	2/123	0.7323212	1	0	0	0.7761414	0.2417960	NTRK2;CUX2
1120	cellular response to steroid hormone stimulus (GO:0071383)	2/123	0.7323212	1	0	0	0.7761414	0.2417960	STC1;NKX3-1
1121	divalent inorganic cation homeostasis (GO:0072507)	5/291	0.7325019	1	0	0	0.8201494	0.2553038	JPH2;C1QTNF1;EDN2;STC1;TNNI3
1122	regulation of response to DNA damage stimulus (GO:2001020)	2/124	0.7364074	1	0	0	0.7698822	0.2355622	MUC1;NKX3-1
1123	positive regulation of endothelial cell proliferation (GO:0001938)	1/63	0.7370948	1	0	0	0.7576619	0.2311162	CCL24
1124	positive regulation of T cell differentiation (GO:0045582)	1/63	0.7370948	1	0	0	0.7576619	0.2311162	ZBTB16
1125	regulation of alpha-beta T cell activation (GO:0046634)	1/63	0.7370948	1	0	0	0.7576619	0.2311162	ZBTB16
1126	regulation of blood vessel size (GO:0050880)	1/63	0.7370948	1	0	0	0.7576619	0.2311162	EDN2
1127	regulation of neurotransmitter transport (GO:0051588)	1/63	0.7370948	1	0	0	0.7576619	0.2311162	NTRK2
1128	divalent inorganic cation transport (GO:0072511)	4/238	0.7376519	1	0	0	0.8022302	0.2441052	JPH2;TCN1;BHLHA15;CACNA1E
1129	negative regulation of cellular component movement (GO:0051271)	3/183	0.7409391	1	0	0	0.7825032	0.2346233	STC1;ALOX15B;THBS1
1130	negative regulation of angiogenesis (GO:0016525)	1/64	0.7426200	1	0	0	0.7458234	0.2219352	THBS1
1131	regulation of tube size (GO:0035150)	1/64	0.7426200	1	0	0	0.7458234	0.2219352	EDN2
1132	regulation of synapse organization (GO:0050807)	1/64	0.7426200	1	0	0	0.7458234	0.2219352	CUX2
1133	positive regulation of stem cell proliferation (GO:2000648)	1/64	0.7426200	1	0	0	0.7458234	0.2219352	PAX6
1134	regulation of actin cytoskeleton organization (GO:0032956)	4/240	0.7435496	1	0	0	0.7955449	0.2357357	CCL24;CSF3;CDC42EP5;MYLK3
1135	negative regulation of sequence-specific DNA binding transcription factor activity (GO:0043433)	2/126	0.7444207	1	0	0	0.7576619	0.2236231	IRAK3;PTHLH
1136	negative regulation of Wnt signaling pathway (GO:0030178)	2/126	0.7444207	1	0	0	0.7576619	0.2236231	SIX3;CTHRC1
1137	glutamine family amino acid metabolic process (GO:0009064)	1/65	0.7480294	1	0	0	0.7343492	0.2131911	PYCR1
1138	negative regulation of ossification (GO:0030279)	1/65	0.7480294	1	0	0	0.7343492	0.2131911	AHSG
1139	negative regulation of NF-kappaB transcription factor activity (GO:0032088)	1/65	0.7480294	1	0	0	0.7343492	0.2131911	IRAK3
1140	negative regulation of lipid metabolic process (GO:0045833)	1/65	0.7480294	1	0	0	0.7343492	0.2131911	ADRA2A
1141	positive regulation of peptide hormone secretion (GO:0090277)	1/65	0.7480294	1	0	0	0.7343492	0.2131911	DOC2B
1142	circadian rhythm (GO:0007623)	2/127	0.7483486	1	0	0	0.7516960	0.2179064	NTRK2;SIX3
1143	calcium ion transmembrane transport (GO:0070588)	2/128	0.7522246	1	0	0	0.7458234	0.2123511	JPH2;CACNA1E
1144	amino acid transport (GO:0006865)	2/128	0.7522246	1	0	0	0.7458234	0.2123511	NTRK2;SLC6A1
1145	regulation of acute inflammatory response (GO:0002673)	1/66	0.7533254	1	0	0	0.7232227	0.2048586	PTGS2
1146	positive regulation of translation (GO:0045727)	1/66	0.7533254	1	0	0	0.7232227	0.2048586	THBS1
1147	negative regulation of blood vessel morphogenesis (GO:2000181)	1/66	0.7533254	1	0	0	0.7232227	0.2048586	THBS1
1148	response to ammonium ion (GO:0060359)	1/66	0.7533254	1	0	0	0.7232227	0.2048586	SLC6A1
1149	negative regulation of apoptotic signaling pathway (GO:2001234)	3/187	0.7540389	1	0	0	0.7657652	0.2161841	MUC1;IL19;THBS1
1150	negative regulation of hydrolase activity (GO:0051346)	6/354	0.7545712	1	0	0	0.8090288	0.2278271	SERPINB4;AHSG;HMSD;SSPO;TNNI3;THBS1
1151	regulation of lipid metabolic process (GO:0019216)	4/245	0.7578527	1	0	0	0.7793093	0.2160761	APOB;PTGS2;ADRA2A;CYP17A1
1152	positive regulation of peptide secretion (GO:0002793)	1/67	0.7585103	1	0	0	0.7124283	0.1969144	DOC2B
1153	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:0006977)	1/67	0.7585103	1	0	0	0.7124283	0.1969144	MUC1
1154	cellular response to mechanical stimulus (GO:0071260)	1/67	0.7585103	1	0	0	0.7124283	0.1969144	PTGS2
1155	regulation of inflammatory response (GO:0050727)	4/247	0.7633989	1	0	0	0.7729991	0.2086901	CCL24;AHSG;ADORA3;PTGS2
1156	negative regulation of catabolic process (GO:0009895)	3/190	0.7635108	1	0	0	0.7536742	0.2033624	IRAK3;TNNI3;ADRA2A
1157	cellular lipid catabolic process (GO:0044242)	2/131	0.7635456	1	0	0	0.7287435	0.1966022	LIPG;APOB
1158	cytokine production (GO:0001816)	1/68	0.7635865	1	0	0	0.7019514	0.1893366	PTGS2
1159	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	1/68	0.7635865	1	0	0	0.7019514	0.1893366	MUC1
1160	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	1/68	0.7635865	1	0	0	0.7019514	0.1893366	MUC1
1161	positive regulation of cell development (GO:0010720)	6/358	0.7639254	1	0	0	0.7999893	0.2154252	NTRK2;CUX2;BRINP1;PAX6;FEZF1;MYLK3
1162	cellular response to biotic stimulus (GO:0071216)	2/132	0.7672185	1	0	0	0.7232227	0.1916422	CSF3;CYP17A1
1163	positive regulation of lymphocyte mediated immunity (GO:0002708)	1/69	0.7685562	1	0	0	0.6917782	0.1821048	AZGP1
1164	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process (GO:0043154)	1/69	0.7685562	1	0	0	0.6917782	0.1821048	THBS1
1165	alpha-amino acid biosynthetic process (GO:1901607)	1/69	0.7685562	1	0	0	0.6917782	0.1821048	PYCR1
1166	positive regulation of cytokine secretion (GO:0050715)	1/69	0.7685562	1	0	0	0.6917782	0.1821048	ALOX15B
1167	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	1/69	0.7685562	1	0	0	0.6917782	0.1821048	MUC1
1168	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	1/69	0.7685562	1	0	0	0.6917782	0.1821048	MUC1
1169	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	1/69	0.7685562	1	0	0	0.6917782	0.1821048	MUC1
1170	negative regulation of myeloid cell differentiation (GO:0045638)	1/69	0.7685562	1	0	0	0.6917782	0.1821048	ZBTB16
1171	adherens junction organization (GO:0034332)	1/69	0.7685562	1	0	0	0.6917782	0.1821048	CDH15
1172	negative regulation of transport (GO:0051051)	6/361	0.7707671	1	0	0	0.7933412	0.2065615	BMP8A;STC1;PTGS2;THBS1;ADRA2A;STXBP5L
1173	activation of MAPK activity (GO:0000187)	2/133	0.7708418	1	0	0	0.7177849	0.1868194	THBS1;ADRA2A
1174	positive regulation of immune effector process (GO:0002699)	2/133	0.7708418	1	0	0	0.7177849	0.1868194	AZGP1;ADORA3
1175	regulation of vesicle-mediated transport (GO:0060627)	5/306	0.7712574	1	0	0	0.7799460	0.2025778	AHSG;ADORA3;DOC2B;ADRA2A;STXBP5L
1176	lipid transport (GO:0006869)	3/193	0.7726851	1	0	0	0.7419590	0.1913392	LIPG;ATP10B;APOB
1177	single-organism behavior (GO:0044708)	6/362	0.7730146	1	0	0	0.7911497	0.2036873	NTRK2;CUX2;PCDH15;SLC6A1;PTGS2;THBS1
1178	hormone secretion (GO:0046879)	1/70	0.7734217	1	0	0	0.6818957	0.1752000	ADORA3
1179	negative regulation of vasculature development (GO:1901343)	1/70	0.7734217	1	0	0	0.6818957	0.1752000	THBS1
1180	response to heat (GO:0009408)	1/70	0.7734217	1	0	0	0.6818957	0.1752000	THBS1
1181	cellular response to cytokine stimulus (GO:0071345)	8/471	0.7736317	1	0	0	0.8107464	0.2080856	CSF3;EDN2;IL1R2;IRAK3;APOB;THBS1;MYLK3;NKX3-1
1182	cell fate commitment (GO:0045165)	2/134	0.7744158	1	0	0	0.7124283	0.1821297	PAX6;WNT16
1183	pyruvate metabolic process (GO:0006090)	1/71	0.7781852	1	0	0	0.6722915	0.1686045	HKDC1
1184	tissue remodeling (GO:0048771)	1/71	0.7781852	1	0	0	0.6722915	0.1686045	WNT16
1185	signal transduction involved in DNA damage checkpoint (GO:0072422)	1/71	0.7781852	1	0	0	0.6722915	0.1686045	MUC1
1186	striated muscle contraction (GO:0006941)	1/71	0.7781852	1	0	0	0.6722915	0.1686045	TNNI3
1187	negative regulation of cysteine-type endopeptidase activity (GO:2000117)	1/71	0.7781852	1	0	0	0.6722915	0.1686045	THBS1
1188	signal transduction involved in DNA integrity checkpoint (GO:0072401)	1/71	0.7781852	1	0	0	0.6722915	0.1686045	MUC1
1189	regulation of epidermal growth factor receptor signaling pathway (GO:0042058)	1/71	0.7781852	1	0	0	0.6722915	0.1686045	ADRA2A
1190	receptor metabolic process (GO:0043112)	1/71	0.7781852	1	0	0	0.6722915	0.1686045	REP15
1191	organophosphate ester transport (GO:0015748)	1/71	0.7781852	1	0	0	0.6722915	0.1686045	ATP10B
1192	positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains (GO:0002824)	1/71	0.7781852	1	0	0	0.6722915	0.1686045	AZGP1
1193	renal system process (GO:0003014)	1/71	0.7781852	1	0	0	0.6722915	0.1686045	HSD11B2
1194	body fluid secretion (GO:0007589)	1/71	0.7781852	1	0	0	0.6722915	0.1686045	CHRM1
1195	biomineral tissue development (GO:0031214)	1/71	0.7781852	1	0	0	0.6722915	0.1686045	PTGS2
1196	positive regulation of cell projection organization (GO:0031346)	3/195	0.7786383	1	0	0	0.7343492	0.1837405	NTRK2;CUX2;CDC42EP5
1197	smoothened signaling pathway (GO:0007224)	1/72	0.7828487	1	0	0	0.6629541	0.1623016	PAX6
1198	regulation of fatty acid metabolic process (GO:0019217)	1/72	0.7828487	1	0	0	0.6629541	0.1623016	PTGS2
1199	regulation of heart rate (GO:0002027)	1/72	0.7828487	1	0	0	0.6629541	0.1623016	EDN2
1200	positive regulation of chromosome organization (GO:2001252)	1/72	0.7828487	1	0	0	0.6629541	0.1623016	MUC1
1201	signal transduction involved in cell cycle checkpoint (GO:0072395)	1/72	0.7828487	1	0	0	0.6629541	0.1623016	MUC1
1202	response to metal ion (GO:0010038)	4/255	0.7846000	1	0	0	0.7487482	0.1816322	TFF1;SLC6A1;PTGS2;THBS1
1203	regulation of ion transmembrane transporter activity (GO:0032412)	2/137	0.7848476	1	0	0	0.6968277	0.1688175	JPH2;ADRA2A
1204	positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway (GO:0090100)	1/73	0.7874144	1	0	0	0.6538726	0.1562759	THBS1
1205	negative regulation of transforming growth factor beta receptor signaling pathway (GO:0030512)	1/73	0.7874144	1	0	0	0.6538726	0.1562759	FBN2
1206	intracellular steroid hormone receptor signaling pathway (GO:0030518)	1/73	0.7874144	1	0	0	0.6538726	0.1562759	NKX3-1
1207	positive regulation of nervous system development (GO:0051962)	5/313	0.7878191	1	0	0	0.7625031	0.1818469	NTRK2;CUX2;BRINP1;PAX6;FEZF1
1208	negative regulation of response to wounding (GO:1903035)	2/138	0.7882296	1	0	0	0.6917782	0.1646196	C1QTNF1;PLAT
1209	positive regulation of peptidyl-tyrosine phosphorylation (GO:0050731)	2/139	0.7915648	1	0	0	0.6868014	0.1605354	CSF3;ADRA2A
1210	positive regulation of adaptive immune response (GO:0002821)	1/74	0.7918844	1	0	0	0.6450364	0.1505127	AZGP1
1211	negative regulation of MAP kinase activity (GO:0043407)	1/74	0.7918844	1	0	0	0.6450364	0.1505127	IRAK3
1212	cellular response to starvation (GO:0009267)	1/74	0.7918844	1	0	0	0.6450364	0.1505127	FOXA3
1213	regulation of ERBB signaling pathway (GO:1901184)	1/74	0.7918844	1	0	0	0.6450364	0.1505127	ADRA2A
1214	spindle organization (GO:0007051)	1/74	0.7918844	1	0	0	0.6450364	0.1505127	NEK6
1215	regulation of epithelial cell proliferation (GO:0050678)	4/258	0.7921515	1	0	0	0.7400418	0.1724317	CCL24;PAX6;THBS1;NKX3-1
1216	regulation of peptidase activity (GO:0052547)	6/372	0.7945911	1	0	0	0.7698822	0.1770172	SERPINB4;AHSG;HMSD;SSPO;THBS1;NKX3-1
1217	cell-substrate adhesion (GO:0031589)	2/140	0.7948536	1	0	0	0.6818957	0.1565614	ITGA10;NID2
1218	glycoprotein metabolic process (GO:0009100)	1/75	0.7962606	1	0	0	0.6364360	0.1449984	B3GNT6
1219	hormone transport (GO:0009914)	1/75	0.7962606	1	0	0	0.6364360	0.1449984	ADORA3
1220	negative regulation of intrinsic apoptotic signaling pathway (GO:2001243)	1/75	0.7962606	1	0	0	0.6364360	0.1449984	MUC1
1221	wound healing (GO:0042060)	1/75	0.7962606	1	0	0	0.6364360	0.1449984	PLAT
1222	positive regulation of lymphocyte differentiation (GO:0045621)	1/75	0.7962606	1	0	0	0.6364360	0.1449984	ZBTB16
1223	regulation of transmembrane transporter activity (GO:0022898)	2/141	0.7980965	1	0	0	0.6770595	0.1526943	JPH2;ADRA2A
1224	response to reactive oxygen species (GO:0000302)	2/141	0.7980965	1	0	0	0.6770595	0.1526943	TPO;PXDN
1225	negative regulation of cell cycle (GO:0045786)	7/430	0.7998336	1	0	0	0.7770439	0.1735540	CGREF1;MUC1;BRINP1;PTGS2;ALOX15B;THBS1;NKX3-1
1226	homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)	2/142	0.8012940	1	0	0	0.6722915	0.1489309	PCDH15;CDH15
1227	response to toxic substance (GO:0009636)	2/142	0.8012940	1	0	0	0.6722915	0.1489309	SLC6A1;CYP17A1
1228	negative regulation of locomotion (GO:0040013)	3/204	0.8038593	1	0	0	0.7019514	0.1532577	STC1;ALOX15B;THBS1
1229	regulation of protein import into nucleus (GO:0042306)	2/143	0.8044466	1	0	0	0.6675902	0.1452681	CSF3;PTGS2
1230	DNA damage checkpoint (GO:0000077)	1/77	0.8047394	1	0	0	0.6199052	0.1346662	NEK6
1231	regulation of smooth muscle cell proliferation (GO:0048660)	1/77	0.8047394	1	0	0	0.6199052	0.1346662	PTGS2
1232	regulation of oxidoreductase activity (GO:0051341)	1/77	0.8047394	1	0	0	0.6199052	0.1346662	EDN2
1233	positive regulation of neuron projection development (GO:0010976)	2/144	0.8075547	1	0	0	0.6629541	0.1417028	NTRK2;CUX2
1234	positive regulation of peptidyl-serine phosphorylation (GO:0033138)	1/78	0.8088459	1	0	0	0.6119577	0.1298249	CSF3
1235	regulation of cell-matrix adhesion (GO:0001952)	1/78	0.8088459	1	0	0	0.6119577	0.1298249	THBS1
1236	regulation of membrane potential (GO:0042391)	4/266	0.8112544	1	0	0	0.7177849	0.1501416	ANO1;CUX2;PYCR1;CACNA1E
1237	regulation of production of molecular mediator of immune response (GO:0002700)	1/79	0.8128663	1	0	0	0.6042114	0.1251858	IRAK3
1238	multicellular organism growth (GO:0035264)	1/79	0.8128663	1	0	0	0.6042114	0.1251858	PCDH15
1239	developmental growth involved in morphogenesis (GO:0060560)	1/79	0.8128663	1	0	0	0.6042114	0.1251858	PTHLH
1240	cytokinesis (GO:0000910)	1/79	0.8128663	1	0	0	0.6042114	0.1251858	NEK6
1241	neuromuscular process (GO:0050905)	1/79	0.8128663	1	0	0	0.6042114	0.1251858	PCDH15
1242	behavior (GO:0007610)	8/494	0.8158309	1	0	0	0.7729991	0.1573426	NTRK2;CUX2;ADM2;SIX3;PCDH15;SLC6A1;PTGS2;THBS1
1243	negative regulation of neuron differentiation (GO:0045665)	2/147	0.8166169	1	0	0	0.6494244	0.1315638	SIX3;PAX6
1244	cell morphogenesis involved in differentiation (GO:0000904)	2/147	0.8166169	1	0	0	0.6494244	0.1315638	STC1;WNT16
1245	regulation of organelle assembly (GO:1902115)	1/80	0.8168022	1	0	0	0.5966587	0.1207388	MYLK3
1246	regulation of protein complex disassembly (GO:0043244)	1/80	0.8168022	1	0	0	0.5966587	0.1207388	IRAK3
1247	Ras protein signal transduction (GO:0007265)	2/148	0.8195518	1	0	0	0.6450364	0.1283607	CDC42EP5;ADRA2A
1248	organic anion transport (GO:0015711)	5/328	0.8201587	1	0	0	0.7276326	0.1442585	NTRK2;SLCO1B3;ATP10B;SLC6A1;SLC13A5
1249	retinoid metabolic process (GO:0001523)	1/81	0.8206556	1	0	0	0.5892926	0.1164747	APOB
1250	negative regulation of immune effector process (GO:0002698)	1/81	0.8206556	1	0	0	0.5892926	0.1164747	IRAK3
1251	protein heterooligomerization (GO:0051291)	1/81	0.8206556	1	0	0	0.5892926	0.1164747	C1QTNF1
1252	regulation of reactive oxygen species metabolic process (GO:2000377)	1/81	0.8206556	1	0	0	0.5892926	0.1164747	THBS1
1253	regulation of cellular amine metabolic process (GO:0033238)	1/82	0.8244281	1	0	0	0.5821061	0.1123845	GPR37
1254	male gonad development (GO:0008584)	1/82	0.8244281	1	0	0	0.5821061	0.1123845	NKX3-1
1255	MyD88-dependent toll-like receptor signaling pathway (GO:0002755)	1/82	0.8244281	1	0	0	0.5821061	0.1123845	IRAK3
1256	organic acid biosynthetic process (GO:0016053)	4/272	0.8246228	1	0	0	0.7019514	0.1353567	EDN2;PYCR1;PTGS2;ALOX15B
1257	carboxylic acid biosynthetic process (GO:0046394)	4/272	0.8246228	1	0	0	0.7019514	0.1353567	EDN2;PYCR1;PTGS2;ALOX15B
1258	positive regulation of defense response (GO:0031349)	4/272	0.8246228	1	0	0	0.7019514	0.1353567	CCL24;ADORA3;IRAK3;PTGS2
1259	actin filament organization (GO:0007015)	2/150	0.8252959	1	0	0	0.6364360	0.1222042	PCDH15;SHROOM1
1260	regulation of organ morphogenesis (GO:2000027)	2/150	0.8252959	1	0	0	0.6364360	0.1222042	CHAD;CTHRC1
1261	activation of cysteine-type endopeptidase activity involved in apoptotic process (GO:0006919)	1/83	0.8281214	1	0	0	0.5750927	0.1084599	NKX3-1
1262	myeloid leukocyte differentiation (GO:0002573)	1/83	0.8281214	1	0	0	0.5750927	0.1084599	CSF3
1263	calcium ion transport (GO:0006816)	3/215	0.8313669	1	0	0	0.6660376	0.1230065	JPH2;BHLHA15;CACNA1E
1264	integrin-mediated signaling pathway (GO:0007229)	1/84	0.8317373	1	0	0	0.5682464	0.1046930	ITGA10
1265	peptidyl-serine phosphorylation (GO:0018105)	1/84	0.8317373	1	0	0	0.5682464	0.1046930	NEK6
1266	regulation of interleukin-6 production (GO:0032675)	1/84	0.8317373	1	0	0	0.5682464	0.1046930	IRAK3
1267	post-embryonic development (GO:0009791)	1/84	0.8317373	1	0	0	0.5682464	0.1046930	APOB
1268	regulation of transporter activity (GO:0032409)	2/153	0.8336044	1	0	0	0.6239568	0.1135578	JPH2;ADRA2A
1269	nucleoside monophosphate biosynthetic process (GO:0009124)	1/85	0.8352772	1	0	0	0.5615611	0.1010763	ENTPD8
1270	positive regulation of cell cycle arrest (GO:0071158)	1/85	0.8352772	1	0	0	0.5615611	0.1010763	MUC1
1271	cellular response to light stimulus (GO:0071482)	1/85	0.8352772	1	0	0	0.5615611	0.1010763	PTGS2
1272	myeloid cell differentiation (GO:0030099)	2/154	0.8362938	1	0	0	0.6199052	0.1108237	CSF3;ZBTB16
1273	positive regulation of MAPK cascade (GO:0043410)	6/395	0.8382122	1	0	0	0.7250536	0.1279603	NTRK2;C1QTNF1;GPR37;WNT16;THBS1;ADRA2A
1274	regulation of binding (GO:0051098)	3/218	0.8382708	1	0	0	0.6568720	0.1158815	CSF3;NKX3-1;CTHRC1
1275	cellular chemical homeostasis (GO:0055082)	7/452	0.8385671	1	0	0	0.7392232	0.1301482	JPH2;C1QTNF1;EDN2;HKDC1;STC1;TNNI3;FOXA3
1276	cell-type specific apoptotic process (GO:0097285)	1/86	0.8387428	1	0	0	0.5550314	0.0976029	SIX3
1277	myeloid leukocyte activation (GO:0002274)	1/86	0.8387428	1	0	0	0.5550314	0.0976029	EDN2
1278	DNA integrity checkpoint (GO:0031570)	1/86	0.8387428	1	0	0	0.5550314	0.0976029	NEK6
1279	negative regulation of homeostatic process (GO:0032845)	1/86	0.8387428	1	0	0	0.5550314	0.0976029	ADRA2A
1280	negative regulation of neuron death (GO:1901215)	2/155	0.8389439	1	0	0	0.6159058	0.1081601	NTRK2;CSF3
1281	multicellular organismal development (GO:0007275)	7/453	0.8401763	1	0	0	0.7375913	0.1284468	CSF3;CATSPERB;PAX6;WNT16;C8ORF22;SPDEF;NKX3-1
1282	negative regulation of mitotic cell cycle (GO:0045930)	3/219	0.8405173	1	0	0	0.6538726	0.1136023	MUC1;BRINP1;NKX3-1
1283	regulation of intracellular protein transport (GO:0033157)	3/219	0.8405173	1	0	0	0.6538726	0.1136023	CSF3;CHRM1;PTGS2
1284	regulation of protein localization to nucleus (GO:1900180)	2/156	0.8415551	1	0	0	0.6119577	0.1055650	CSF3;PTGS2
1285	triglyceride metabolic process (GO:0006641)	1/87	0.8421357	1	0	0	0.5486517	0.0942661	APOB
1286	regulation of receptor activity (GO:0010469)	1/87	0.8421357	1	0	0	0.5486517	0.0942661	ADRA2A
1287	diterpenoid metabolic process (GO:0016101)	1/87	0.8421357	1	0	0	0.5486517	0.0942661	APOB
1288	activation of cysteine-type endopeptidase activity (GO:0097202)	1/88	0.8454574	1	0	0	0.5424170	0.0910596	NKX3-1
1289	adult locomotory behavior (GO:0008344)	1/88	0.8454574	1	0	0	0.5424170	0.0910596	PCDH15
1290	sensory perception (GO:0007600)	7/457	0.8464860	1	0	0	0.7311354	0.1218522	OMP;SIX3;GRM8;PCDH15;PAX6;PTGS2;ADRA2A
1291	energy reserve metabolic process (GO:0006112)	2/158	0.8466628	1	0	0	0.6042114	0.1005726	CACNA1E;ADRA2A
1292	phototransduction, visible light (GO:0007603)	1/89	0.8487093	1	0	0	0.5363224	0.0879775	APOB
1293	chromosome segregation (GO:0007059)	1/89	0.8487093	1	0	0	0.5363224	0.0879775	NEK6
1294	RNA phosphodiester bond hydrolysis (GO:0090501)	1/89	0.8487093	1	0	0	0.5363224	0.0879775	AZGP1
1295	stress-activated MAPK cascade (GO:0051403)	1/89	0.8487093	1	0	0	0.5363224	0.0879775	CDC42EP5
1296	cell junction assembly (GO:0034329)	2/160	0.8516207	1	0	0	0.5966587	0.0958317	CDH15;FLNC
1297	water-soluble vitamin metabolic process (GO:0006767)	1/90	0.8518930	1	0	0	0.5303633	0.0850142	TCN1
1298	positive regulation of endocytosis (GO:0045807)	1/90	0.8518930	1	0	0	0.5303633	0.0850142	AHSG
1299	regulation of cellular response to stress (GO:0080135)	6/404	0.8531191	1	0	0	0.7089014	0.1126133	MUC1;GPR37;NEK6;PYCR1;WNT16;NKX3-1
1300	regulation of extrinsic apoptotic signaling pathway (GO:2001236)	2/161	0.8540446	1	0	0	0.5929528	0.0935513	IL19;THBS1
1301	regulation of protein secretion (GO:0050708)	2/161	0.8540446	1	0	0	0.5929528	0.0935513	ALOX15B;STXBP5L
1302	regulation of neuron differentiation (GO:0045664)	6/405	0.8547041	1	0	0	0.7071511	0.1110227	NTRK2;CUX2;BRINP1;SIX3;PAX6;FEZF1
1303	negative regulation of canonical Wnt signaling pathway (GO:0090090)	1/91	0.8550098	1	0	0	0.5245351	0.0821644	CTHRC1
1304	stress-activated protein kinase signaling cascade (GO:0031098)	1/91	0.8550098	1	0	0	0.5245351	0.0821644	CDC42EP5
1305	DNA damage response, signal transduction by p53 class mediator (GO:0030330)	1/91	0.8550098	1	0	0	0.5245351	0.0821644	MUC1
1306	leukocyte migration (GO:0050900)	3/226	0.8555008	1	0	0	0.6336199	0.0988879	CCL24;EDN2;APOB
1307	iron ion homeostasis (GO:0055072)	1/92	0.8580612	1	0	0	0.5188337	0.0794230	LCN2
1308	alpha-amino acid catabolic process (GO:1901606)	1/92	0.8580612	1	0	0	0.5188337	0.0794230	ALDH1L2
1309	acylglycerol metabolic process (GO:0006639)	1/93	0.8610486	1	0	0	0.5132548	0.0767852	APOB
1310	hormone-mediated signaling pathway (GO:0009755)	1/93	0.8610486	1	0	0	0.5132548	0.0767852	NKX3-1
1311	regulation of cytokine biosynthetic process (GO:0042035)	1/93	0.8610486	1	0	0	0.5132548	0.0767852	THBS1
1312	positive regulation of cell-substrate adhesion (GO:0010811)	1/93	0.8610486	1	0	0	0.5132548	0.0767852	THBS1
1313	regulation of glucose metabolic process (GO:0010906)	1/94	0.8639732	1	0	0	0.5077946	0.0742465	C1QTNF1
1314	regulation of cell-cell adhesion (GO:0022407)	1/94	0.8639732	1	0	0	0.5077946	0.0742465	C1QTNF1
1315	neutral lipid metabolic process (GO:0006638)	1/94	0.8639732	1	0	0	0.5077946	0.0742465	APOB
1316	regulation of behavior (GO:0050795)	2/166	0.8656311	1	0	0	0.5750927	0.0829838	EDN2;THBS1
1317	regulation of endopeptidase activity (GO:0052548)	5/354	0.8667283	1	0	0	0.6741906	0.0964293	SERPINB4;AHSG;HMSD;THBS1;NKX3-1
1318	response to drug (GO:0042493)	5/354	0.8667283	1	0	0	0.6741906	0.0964293	HSD11B2;PTGS2;THBS1;CYP17A1;NKX3-1
1319	regulation of lymphocyte mediated immunity (GO:0002706)	1/95	0.8668363	1	0	0	0.5024494	0.0718026	AZGP1
1320	purine nucleoside biosynthetic process (GO:0042451)	1/95	0.8668363	1	0	0	0.5024494	0.0718026	SLC26A2
1321	negative regulation of binding (GO:0051100)	1/95	0.8668363	1	0	0	0.5024494	0.0718026	NKX3-1
1322	cellular hormone metabolic process (GO:0034754)	1/95	0.8668363	1	0	0	0.5024494	0.0718026	CYP17A1
1323	purine ribonucleoside biosynthetic process (GO:0046129)	1/95	0.8668363	1	0	0	0.5024494	0.0718026	SLC26A2
1324	regulation of protein targeting (GO:1903533)	2/167	0.8678449	1	0	0	0.5716491	0.0810269	CSF3;PTGS2
1325	heart development (GO:0007507)	2/167	0.8678449	1	0	0	0.5716491	0.0810269	TNNI3;NKX3-1
1326	fat cell differentiation (GO:0045444)	1/96	0.8696394	1	0	0	0.4972156	0.0694494	PTGS2
1327	positive regulation of I-kappaB kinase/NF-kappaB signaling (GO:0043123)	2/168	0.8700252	1	0	0	0.5682464	0.0791187	NEK6;PTGS2
1328	divalent metal ion transport (GO:0070838)	3/234	0.8711076	1	0	0	0.6119577	0.0844439	JPH2;BHLHA15;CACNA1E
1329	peptidyl-serine modification (GO:0018209)	1/97	0.8723836	1	0	0	0.4920897	0.0671831	NEK6
1330	regulation of histone modification (GO:0031056)	1/97	0.8723836	1	0	0	0.4920897	0.0671831	MUC1
1331	terpenoid metabolic process (GO:0006721)	1/97	0.8723836	1	0	0	0.4920897	0.0671831	APOB
1332	negative regulation of protein catabolic process (GO:0042177)	1/97	0.8723836	1	0	0	0.4920897	0.0671831	IRAK3
1333	regulation of T cell differentiation (GO:0045580)	1/97	0.8723836	1	0	0	0.4920897	0.0671831	ZBTB16
1334	angiogenesis (GO:0001525)	3/236	0.8747695	1	0	0	0.6067716	0.0811829	ADM2;PTGS2;THBS1
1335	regulation of peptidyl-serine phosphorylation (GO:0033135)	1/98	0.8750701	1	0	0	0.4870683	0.0649999	CSF3
1336	cellular metal ion homeostasis (GO:0006875)	5/361	0.8773846	1	0	0	0.6611177	0.0864807	JPH2;C1QTNF1;EDN2;STC1;TNNI3
1337	cellular response to nutrient levels (GO:0031669)	1/99	0.8777003	1	0	0	0.4821485	0.0628963	FOXA3
1338	negative regulation of G1/S transition of mitotic cell cycle (GO:2000134)	1/99	0.8777003	1	0	0	0.4821485	0.0628963	MUC1
1339	negative regulation of cell cycle G1/S phase transition (GO:1902807)	1/99	0.8777003	1	0	0	0.4821485	0.0628963	MUC1
1340	DNA conformation change (GO:0071103)	1/99	0.8777003	1	0	0	0.4821485	0.0628963	RTEL1-TNFRSF6B
1341	metal ion homeostasis (GO:0055065)	6/422	0.8795660	1	0	0	0.6786639	0.0870906	JPH2;C1QTNF1;EDN2;LCN2;STC1;TNNI3
1342	actin filament-based process (GO:0030029)	4/303	0.8817532	1	0	0	0.6301346	0.0792981	DAAM2;TNNI3;MYLK3;ADRA2A
1343	regulation of Rho GTPase activity (GO:0032319)	2/174	0.8824274	1	0	0	0.5486517	0.0686247	CCL24;NTRK2
1344	protein localization to nucleus (GO:0034504)	1/101	0.8827960	1	0	0	0.4726010	0.0589150	ZBTB16
1345	detection of external stimulus (GO:0009581)	2/175	0.8843850	1	0	0	0.5455165	0.0670237	PCDH15;APOB
1346	hematopoietic or lymphoid organ development (GO:0048534)	2/175	0.8843850	1	0	0	0.5455165	0.0670237	TPO;ZBTB16
1347	regulation of chromatin modification (GO:1903308)	1/102	0.8852638	1	0	0	0.4679676	0.0570310	MUC1
1348	peptidyl-tyrosine dephosphorylation (GO:0035335)	1/102	0.8852638	1	0	0	0.4679676	0.0570310	PTPRH
1349	neuron projection guidance (GO:0097485)	5/367	0.8859348	1	0	0	0.6503092	0.0787602	UNC5A;ITGA10;SEMA3B;PAX6;FEZF1
1350	axon guidance (GO:0007411)	5/367	0.8859348	1	0	0	0.6503092	0.0787602	UNC5A;ITGA10;SEMA3B;PAX6;FEZF1
1351	regulation of cellular response to growth factor stimulus (GO:0090287)	2/176	0.8863125	1	0	0	0.5424170	0.0654620	FBN2;THBS1
1352	positive regulation of mitotic cell cycle (GO:0045931)	1/103	0.8876798	1	0	0	0.4634242	0.0552143	NKX3-1
1353	regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains (GO:0002822)	1/103	0.8876798	1	0	0	0.4634242	0.0552143	AZGP1
1354	negative regulation of immune response (GO:0050777)	1/103	0.8876798	1	0	0	0.4634242	0.0552143	IRAK3
1355	regulation of protein complex assembly (GO:0043254)	3/244	0.8885121	1	0	0	0.5868774	0.0693730	CCL24;CSF3;CDC42EP5
1356	detection of visible light (GO:0009584)	1/104	0.8900451	1	0	0	0.4589682	0.0534621	APOB
1357	antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)	1/104	0.8900451	1	0	0	0.4589682	0.0534621	AZGP1
1358	detection of abiotic stimulus (GO:0009582)	2/178	0.8900786	1	0	0	0.5363224	0.0624523	PCDH15;APOB
1359	regulation of nucleocytoplasmic transport (GO:0046822)	2/178	0.8900786	1	0	0	0.5363224	0.0624523	CSF3;PTGS2
1360	regulation of cell cycle arrest (GO:0071156)	1/105	0.8923606	1	0	0	0.4545971	0.0517718	MUC1
1361	response to starvation (GO:0042594)	1/106	0.8946275	1	0	0	0.4503085	0.0501409	FOXA3
1362	cellular amino acid biosynthetic process (GO:0008652)	1/106	0.8946275	1	0	0	0.4503085	0.0501409	PYCR1
1363	signal transduction in response to DNA damage (GO:0042770)	1/106	0.8946275	1	0	0	0.4503085	0.0501409	MUC1
1364	regulation of cytokine secretion (GO:0050707)	1/106	0.8946275	1	0	0	0.4503085	0.0501409	ALOX15B
1365	cell growth (GO:0016049)	1/106	0.8946275	1	0	0	0.4503085	0.0501409	LEFTY1
1366	response to glucose (GO:0009749)	1/106	0.8946275	1	0	0	0.4503085	0.0501409	THBS1
1367	synaptic transmission (GO:0007268)	6/434	0.8948836	1	0	0	0.6598990	0.0732894	CHRM1;OMP;KCNN2;PLAT;SLC6A1;CACNA1E
1368	negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway (GO:0090101)	1/107	0.8968468	1	0	0	0.4461000	0.0485670	FBN2
1369	cholesterol metabolic process (GO:0008203)	1/107	0.8968468	1	0	0	0.4461000	0.0485670	APOB
1370	regulation of chromatin organization (GO:1902275)	1/107	0.8968468	1	0	0	0.4461000	0.0485670	MUC1
1371	positive regulation of JNK cascade (GO:0046330)	1/107	0.8968468	1	0	0	0.4461000	0.0485670	WNT16
1372	maintenance of protein location (GO:0045185)	1/108	0.8990194	1	0	0	0.4419694	0.0470479	FBN2
1373	phototransduction (GO:0007602)	1/109	0.9011464	1	0	0	0.4379147	0.0455814	APOB
1374	cell recognition (GO:0008037)	1/109	0.9011464	1	0	0	0.4379147	0.0455814	CATSPERB
1375	regulation of protein transport (GO:0051223)	5/379	0.9015132	1	0	0	0.6297190	0.0652896	CSF3;CHRM1;PTGS2;ALOX15B;STXBP5L
1376	actin cytoskeleton organization (GO:0030036)	3/253	0.9023500	1	0	0	0.5660004	0.0581582	DAAM2;MYLK3;ADRA2A
1377	negative regulation of cytokine production (GO:0001818)	2/185	0.9023675	1	0	0	0.5160292	0.0530134	IRAK3;THBS1
1378	cellular response to external stimulus (GO:0071496)	2/185	0.9023675	1	0	0	0.5160292	0.0530134	PTGS2;FOXA3
1379	ribonucleoside biosynthetic process (GO:0042455)	1/110	0.9032287	1	0	0	0.4339336	0.0441655	SLC26A2
1380	regulation of cysteine-type endopeptidase activity involved in apoptotic process (GO:0043281)	2/186	0.9040148	1	0	0	0.5132548	0.0517923	THBS1;NKX3-1
1381	cellular component assembly involved in morphogenesis (GO:0010927)	2/186	0.9040148	1	0	0	0.5132548	0.0517923	PCDH15;MYLK3
1382	regulation of transmembrane receptor protein serine/threonine kinase signaling pathway (GO:0090092)	2/186	0.9040148	1	0	0	0.5132548	0.0517923	FBN2;THBS1
1383	response to alkaloid (GO:0043279)	1/111	0.9052673	1	0	0	0.4300243	0.0427982	SLC6A1
1384	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process (GO:0043280)	1/111	0.9052673	1	0	0	0.4300243	0.0427982	NKX3-1
1385	synapse organization (GO:0050808)	1/111	0.9052673	1	0	0	0.4300243	0.0427982	NTRK2
1386	mitochondrial transport (GO:0006839)	1/111	0.9052673	1	0	0	0.4300243	0.0427982	BHLHA15
1387	hexose metabolic process (GO:0019318)	2/187	0.9056361	1	0	0	0.5105101	0.0506006	FUT6;HKDC1
1388	regulation of mitosis (GO:0007088)	1/112	0.9072629	1	0	0	0.4261848	0.0414776	NEK6
1389	regulation of striated muscle tissue development (GO:0016202)	1/112	0.9072629	1	0	0	0.4261848	0.0414776	JPH2
1390	gonad development (GO:0008406)	1/112	0.9072629	1	0	0	0.4261848	0.0414776	NKX3-1
1391	regulation of adaptive immune response (GO:0002819)	1/112	0.9072629	1	0	0	0.4261848	0.0414776	AZGP1
1392	cell junction organization (GO:0034330)	2/189	0.9088024	1	0	0	0.5051079	0.0483022	CDH15;FLNC
1393	regulation of peptidyl-tyrosine phosphorylation (GO:0050730)	2/189	0.9088024	1	0	0	0.5051079	0.0483022	CSF3;ADRA2A
1394	peptide metabolic process (GO:0006518)	1/113	0.9092167	1	0	0	0.4224132	0.0402018	CPE
1395	regulation of muscle tissue development (GO:1901861)	1/113	0.9092167	1	0	0	0.4224132	0.0402018	JPH2
1396	cell-cell adhesion via plasma-membrane adhesion molecules (GO:0098742)	2/190	0.9103481	1	0	0	0.5024494	0.0471942	PCDH15;CDH15
1397	regulation of muscle organ development (GO:0048634)	1/114	0.9111294	1	0	0	0.4187079	0.0389693	JPH2
1398	neuropeptide signaling pathway (GO:0007218)	1/114	0.9111294	1	0	0	0.4187079	0.0389693	CPE
1399	isoprenoid metabolic process (GO:0006720)	1/114	0.9111294	1	0	0	0.4187079	0.0389693	APOB
1400	regulation of axonogenesis (GO:0050770)	1/114	0.9111294	1	0	0	0.4187079	0.0389693	NTRK2
1401	cell-cell adhesion (GO:0098609)	2/191	0.9118692	1	0	0	0.4998188	0.0461126	PCDH15;CDH15
1402	regulation of protein catabolic process (GO:0042176)	3/260	0.9120218	1	0	0	0.5507619	0.0507204	NEK6;IRAK3;ADRA2A
1403	cellular cation homeostasis (GO:0030003)	5/389	0.9130524	1	0	0	0.6135308	0.0558080	JPH2;C1QTNF1;EDN2;STC1;TNNI3
1404	negative regulation of neurogenesis (GO:0050768)	2/192	0.9133661	1	0	0	0.4972156	0.0450569	SIX3;PAX6
1405	positive regulation of cytokine production (GO:0001819)	4/327	0.9141706	1	0	0	0.5838862	0.0523968	PTGS2;ALOX15B;THBS1;ADRA2A
1406	positive regulation of leukocyte activation (GO:0002696)	3/262	0.9146211	1	0	0	0.5465576	0.0487777	ADORA3;ZBTB16;THBS1
1407	extracellular matrix disassembly (GO:0022617)	1/116	0.9148349	1	0	0	0.4114888	0.0366273	FBN2
1408	regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032434)	1/116	0.9148349	1	0	0	0.4114888	0.0366273	NEK6
1409	taxis (GO:0042330)	3/263	0.9158945	1	0	0	0.5444794	0.0478348	CCL24;EDN2;CXCL2
1410	chemotaxis (GO:0006935)	3/263	0.9158945	1	0	0	0.5444794	0.0478348	CCL24;EDN2;CXCL2
1411	growth (GO:0040007)	4/329	0.9164779	1	0	0	0.5803367	0.0506154	LEFTY1;PCDH15;BMP8A;PTHLH
1412	cellular amino acid catabolic process (GO:0009063)	1/117	0.9166295	1	0	0	0.4079718	0.0355147	ALDH1L2
1413	response to UV (GO:0009411)	1/117	0.9166295	1	0	0	0.4079718	0.0355147	PTGS2
1414	regulation of immune effector process (GO:0002697)	3/264	0.9171505	1	0	0	0.5424170	0.0469102	AZGP1;ADORA3;IRAK3
1415	regulation of cell cycle phase transition (GO:1901987)	3/264	0.9171505	1	0	0	0.5424170	0.0469102	MUC1;NEK6;SIX3
1416	muscle contraction (GO:0006936)	2/195	0.9177153	1	0	0	0.4895661	0.0420381	EDN2;TNNI3
1417	cilium assembly (GO:0042384)	1/118	0.9183864	1	0	0	0.4045144	0.0344392	PCDH15
1418	negative regulation of protein serine/threonine kinase activity (GO:0071901)	1/118	0.9183864	1	0	0	0.4045144	0.0344392	IRAK3
1419	positive regulation of leukocyte differentiation (GO:1902107)	1/118	0.9183864	1	0	0	0.4045144	0.0344392	ZBTB16
1420	positive regulation of stress-activated MAPK cascade (GO:0032874)	1/118	0.9183864	1	0	0	0.4045144	0.0344392	WNT16
1421	embryonic organ development (GO:0048568)	1/119	0.9201063	1	0	0	0.4011151	0.0333993	TPO
1422	cellular response to extracellular stimulus (GO:0031668)	1/119	0.9201063	1	0	0	0.4011151	0.0333993	FOXA3
1423	positive regulation of stress-activated protein kinase signaling cascade (GO:0070304)	1/119	0.9201063	1	0	0	0.4011151	0.0333993	WNT16
1424	nucleoside biosynthetic process (GO:0009163)	1/119	0.9201063	1	0	0	0.4011151	0.0333993	SLC26A2
1425	positive regulation of cysteine-type endopeptidase activity (GO:2001056)	1/119	0.9201063	1	0	0	0.4011151	0.0333993	NKX3-1
1426	muscle cell differentiation (GO:0042692)	1/119	0.9201063	1	0	0	0.4011151	0.0333993	CDH15
1427	regulation of cysteine-type endopeptidase activity (GO:2000116)	2/197	0.9204999	1	0	0	0.4845959	0.0401431	THBS1;NKX3-1
1428	positive regulation of MAP kinase activity (GO:0043406)	2/197	0.9204999	1	0	0	0.4845959	0.0401431	THBS1;ADRA2A
1429	positive regulation of cell division (GO:0051781)	1/120	0.9217900	1	0	0	0.3977725	0.0323937	NKX3-1
1430	regulation of cell projection assembly (GO:0060491)	1/120	0.9217900	1	0	0	0.3977725	0.0323937	CDC42EP5
1431	negative regulation of defense response (GO:0031348)	1/120	0.9217900	1	0	0	0.3977725	0.0323937	IRAK3
1432	glycosyl compound biosynthetic process (GO:1901659)	1/120	0.9217900	1	0	0	0.3977725	0.0323937	SLC26A2
1433	transition metal ion homeostasis (GO:0055076)	1/120	0.9217900	1	0	0	0.3977725	0.0323937	LCN2
1434	energy derivation by oxidation of organic compounds (GO:0015980)	2/198	0.9218588	1	0	0	0.4821485	0.0392291	CACNA1E;ADRA2A
1435	cellular modified amino acid metabolic process (GO:0006575)	2/199	0.9231959	1	0	0	0.4797256	0.0383367	TPO;ALDH1L2
1436	embryonic organ morphogenesis (GO:0048562)	1/121	0.9234384	1	0	0	0.3944851	0.0314212	PAX6
1437	detection of light stimulus (GO:0009583)	1/121	0.9234384	1	0	0	0.3944851	0.0314212	APOB
1438	plasma membrane organization (GO:0007009)	1/121	0.9234384	1	0	0	0.3944851	0.0314212	ANO7
1439	response to temperature stimulus (GO:0009266)	1/122	0.9250521	1	0	0	0.3912516	0.0304806	THBS1
1440	vitamin metabolic process (GO:0006766)	1/122	0.9250521	1	0	0	0.3912516	0.0304806	TCN1
1441	toll-like receptor signaling pathway (GO:0002224)	1/122	0.9250521	1	0	0	0.3912516	0.0304806	IRAK3
1442	cellular ion homeostasis (GO:0006873)	5/402	0.9262719	1	0	0	0.5936903	0.0454692	JPH2;C1QTNF1;EDN2;STC1;TNNI3
1443	positive regulation of cell activation (GO:0050867)	3/272	0.9266000	1	0	0	0.5264636	0.0401341	ADORA3;ZBTB16;THBS1
1444	positive regulation of multi-organism process (GO:0043902)	1/123	0.9266318	1	0	0	0.3880707	0.0295706	PLAT
1445	cation homeostasis (GO:0055080)	6/465	0.9269710	1	0	0	0.6159058	0.0467060	JPH2;C1QTNF1;EDN2;LCN2;STC1;TNNI3
1446	embryonic morphogenesis (GO:0048598)	5/403	0.9272110	1	0	0	0.5922171	0.0447563	FBN2;ZBTB16;SIX3;PAX6;CTHRC1
1447	regulation of MAP kinase activity (GO:0043405)	3/273	0.9277092	1	0	0	0.5245351	0.0393595	IRAK3;THBS1;ADRA2A
1448	regulation of lymphocyte differentiation (GO:0045619)	1/124	0.9281784	1	0	0	0.3849411	0.0286902	ZBTB16
1449	sensory perception of sound (GO:0007605)	1/124	0.9281784	1	0	0	0.3849411	0.0286902	PCDH15
1450	aging (GO:0007568)	2/204	0.9295640	1	0	0	0.4679676	0.0341802	NTRK2;WNT16
1451	cilium organization (GO:0044782)	1/125	0.9296924	1	0	0	0.3818616	0.0278383	PCDH15
1452	cytokine-mediated signaling pathway (GO:0019221)	4/342	0.9301713	1	0	0	0.5582772	0.0404117	CSF3;EDN2;IL1R2;IRAK3
1453	purine ribonucleotide biosynthetic process (GO:0009152)	1/126	0.9311745	1	0	0	0.3788309	0.0270139	SLC26A2
1454	positive regulation of NF-kappaB transcription factor activity (GO:0051092)	1/126	0.9311745	1	0	0	0.3788309	0.0270139	IRAK3
1455	cellular response to radiation (GO:0071478)	1/126	0.9311745	1	0	0	0.3788309	0.0270139	PTGS2
1456	nervous system development (GO:0007399)	3/277	0.9319940	1	0	0	0.5169606	0.0364090	SEMA6B;CHRM1;APOB
1457	response to ionizing radiation (GO:0010212)	1/127	0.9326255	1	0	0	0.3758480	0.0262160	CYP17A1
1458	sensory perception of mechanical stimulus (GO:0050954)	1/127	0.9326255	1	0	0	0.3758480	0.0262160	PCDH15
1459	coagulation (GO:0050817)	6/472	0.9328994	1	0	0	0.6067716	0.0421451	ITGA10;PLAT;APOB;THBS1;ADRA2A;F5
1460	blood coagulation (GO:0007596)	6/472	0.9328994	1	0	0	0.6067716	0.0421451	ITGA10;PLAT;APOB;THBS1;ADRA2A;F5
1461	organelle assembly (GO:0070925)	3/278	0.9330281	1	0	0	0.5151010	0.0357068	NEK6;PCDH15;MYLK3
1462	positive regulation of endopeptidase activity (GO:0010950)	1/128	0.9340460	1	0	0	0.3729117	0.0254436	NKX3-1
1463	fatty acid metabolic process (GO:0006631)	3/280	0.9350530	1	0	0	0.5114218	0.0343430	EDN2;PTGS2;ALOX15B
1464	nucleoside phosphate biosynthetic process (GO:1901293)	2/209	0.9354316	1	0	0	0.4567722	0.0304883	SLC26A2;ENTPD8
1465	cellular potassium ion transport (GO:0071804)	1/129	0.9354366	1	0	0	0.3700209	0.0246959	KCNN2
1466	potassium ion transmembrane transport (GO:0071805)	1/129	0.9354366	1	0	0	0.3700209	0.0246959	KCNN2
1467	regulation of G1/S transition of mitotic cell cycle (GO:2000045)	1/129	0.9354366	1	0	0	0.3700209	0.0246959	MUC1
1468	organelle localization (GO:0051640)	1/129	0.9354366	1	0	0	0.3700209	0.0246959	BHLHA15
1469	positive regulation of protein catabolic process (GO:0045732)	1/130	0.9367979	1	0	0	0.3671746	0.0239720	ADRA2A
1470	negative regulation of MAPK cascade (GO:0043409)	1/130	0.9367979	1	0	0	0.3671746	0.0239720	IRAK3
1471	positive regulation of homeostatic process (GO:0032846)	1/130	0.9367979	1	0	0	0.3671746	0.0239720	PTGS2
1472	regulation of cytoskeleton organization (GO:0051493)	4/350	0.9375583	1	0	0	0.5455165	0.0351729	CCL24;CSF3;CDC42EP5;MYLK3
1473	hemostasis (GO:0007599)	6/478	0.9376387	1	0	0	0.5991552	0.0385800	ITGA10;PLAT;APOB;THBS1;ADRA2A;F5
1474	negative regulation of nervous system development (GO:0051961)	2/211	0.9376466	1	0	0	0.4524426	0.0291292	SIX3;PAX6
1475	cell division (GO:0051301)	1/131	0.9381306	1	0	0	0.3643717	0.0232710	ZBTB16
1476	regulation of cell cycle G1/S phase transition (GO:1902806)	1/131	0.9381306	1	0	0	0.3643717	0.0232710	MUC1
1477	signal transduction by p53 class mediator (GO:0072331)	1/132	0.9394353	1	0	0	0.3616113	0.0225922	MUC1
1478	purine nucleotide biosynthetic process (GO:0006164)	1/132	0.9394353	1	0	0	0.3616113	0.0225922	SLC26A2
1479	regulation of I-kappaB kinase/NF-kappaB signaling (GO:0043122)	2/213	0.9397895	1	0	0	0.4481943	0.0278326	NEK6;PTGS2
1480	alpha-amino acid metabolic process (GO:1901605)	2/213	0.9397895	1	0	0	0.4481943	0.0278326	PYCR1;ALDH1L2
1481	negative regulation of neuron apoptotic process (GO:0043524)	1/133	0.9407125	1	0	0	0.3588925	0.0219347	NTRK2
1482	regulation of Wnt signaling pathway (GO:0030111)	2/214	0.9408346	1	0	0	0.4461000	0.0272067	SIX3;CTHRC1
1483	negative regulation of response to external stimulus (GO:0032102)	2/215	0.9418624	1	0	0	0.4440251	0.0265954	C1QTNF1;PLAT
1484	transforming growth factor beta receptor signaling pathway (GO:0007179)	1/134	0.9419629	1	0	0	0.3562142	0.0212978	LEFTY1
1485	amine metabolic process (GO:0009308)	1/134	0.9419629	1	0	0	0.3562142	0.0212978	SULT1C2
1486	regulation of apoptotic signaling pathway (GO:2001233)	4/356	0.9426257	1	0	0	0.5363224	0.0316892	MUC1;IL19;THBS1;NKX3-1
1487	response to unfolded protein (GO:0006986)	1/135	0.9431869	1	0	0	0.3535755	0.0206809	THBS1
1488	regulation of proteasomal protein catabolic process (GO:0061136)	1/135	0.9431869	1	0	0	0.3535755	0.0206809	NEK6
1489	negative regulation of cell activation (GO:0050866)	1/135	0.9431869	1	0	0	0.3535755	0.0206809	C1QTNF1
1490	cellular response to organic cyclic compound (GO:0071407)	3/291	0.9452165	1	0	0	0.4920897	0.0277250	STC1;PTGS2;NKX3-1
1491	regulation of cellular carbohydrate metabolic process (GO:0010675)	1/137	0.9455582	1	0	0	0.3484138	0.0195041	C1QTNF1
1492	regulation of G-protein coupled receptor protein signaling pathway (GO:0008277)	1/137	0.9455582	1	0	0	0.3484138	0.0195041	ADRA2A
1493	regulation of nuclear division (GO:0051783)	1/138	0.9467066	1	0	0	0.3458891	0.0189430	NEK6
1494	lipid biosynthetic process (GO:0008610)	6/491	0.9469014	1	0	0	0.5832916	0.0318246	HSD11B2;EDN2;TFCP2L1;PTGS2;ALOX15B;CYP17A1
1495	negative regulation of growth (GO:0045926)	2/221	0.9476823	1	0	0	0.4319701	0.0232123	CGREF1;ALOX15B
1496	monosaccharide metabolic process (GO:0005996)	2/221	0.9476823	1	0	0	0.4319701	0.0232123	FUT6;HKDC1
1497	positive regulation of peptidase activity (GO:0010952)	1/139	0.9478308	1	0	0	0.3434007	0.0183992	NKX3-1
1498	neuron differentiation (GO:0030182)	2/222	0.9485967	1	0	0	0.4300243	0.0226931	NTRK2;WNT16
1499	ribonucleotide biosynthetic process (GO:0009260)	1/140	0.9489314	1	0	0	0.3409478	0.0178721	SLC26A2
1500	adult behavior (GO:0030534)	1/141	0.9500087	1	0	0	0.3385298	0.0173612	PCDH15
1501	sodium ion transport (GO:0006814)	1/141	0.9500087	1	0	0	0.3385298	0.0173612	SLC13A5
1502	branching morphogenesis of an epithelial tube (GO:0048754)	1/141	0.9500087	1	0	0	0.3385298	0.0173612	NKX3-1
1503	pattern recognition receptor signaling pathway (GO:0002221)	1/142	0.9510635	1	0	0	0.3361458	0.0168659	IRAK3
1504	regulation of neuron death (GO:1901214)	2/225	0.9512495	1	0	0	0.4242906	0.0212056	NTRK2;CSF3
1505	response to topologically incorrect protein (GO:0035966)	1/143	0.9520960	1	0	0	0.3337951	0.0163858	THBS1
1506	ribose phosphate biosynthetic process (GO:0046390)	1/144	0.9531067	1	0	0	0.3314771	0.0159203	SLC26A2
1507	positive regulation of epithelial cell proliferation (GO:0050679)	1/144	0.9531067	1	0	0	0.3314771	0.0159203	CCL24
1508	innate immune response-activating signal transduction (GO:0002758)	1/144	0.9531067	1	0	0	0.3314771	0.0159203	IRAK3
1509	positive regulation of proteolysis (GO:0045862)	2/228	0.9537715	1	0	0	0.4187079	0.0198179	ADRA2A;NKX3-1
1510	regulation of carbohydrate metabolic process (GO:0006109)	1/145	0.9540962	1	0	0	0.3291910	0.0154689	C1QTNF1
1511	sulfur compound biosynthetic process (GO:0044272)	1/145	0.9540962	1	0	0	0.3291910	0.0154689	SLC26A2
1512	response to endoplasmic reticulum stress (GO:0034976)	1/145	0.9540962	1	0	0	0.3291910	0.0154689	THBS1
1513	negative regulation of cellular catabolic process (GO:0031330)	1/145	0.9540962	1	0	0	0.3291910	0.0154689	TNNI3
1514	purine-containing compound biosynthetic process (GO:0072522)	1/146	0.9550649	1	0	0	0.3269363	0.0150312	SLC26A2
1515	protein homooligomerization (GO:0051260)	2/230	0.9553831	1	0	0	0.4150669	0.0189449	C1QTNF1;SLC6A1
1516	regulation of establishment of protein localization (GO:0070201)	5/442	0.9564577	1	0	0	0.5399626	0.0240385	CSF3;CHRM1;PTGS2;ALOX15B;STXBP5L
1517	lipid catabolic process (GO:0016042)	2/232	0.9569409	1	0	0	0.4114888	0.0181111	LIPG;APOB
1518	regulation of proteolysis involved in cellular protein catabolic process (GO:1903050)	1/148	0.9569415	1	0	0	0.3225182	0.0141950	NEK6
1519	regulation of JNK cascade (GO:0046328)	1/148	0.9569415	1	0	0	0.3225182	0.0141950	WNT16
1520	regulation of cell-substrate adhesion (GO:0010810)	1/149	0.9578502	1	0	0	0.3203537	0.0137957	THBS1
1521	positive regulation of Rho GTPase activity (GO:0032321)	1/149	0.9578502	1	0	0	0.3203537	0.0137957	CCL24
1522	regulation of cell division (GO:0051302)	2/234	0.9584467	1	0	0	0.4079718	0.0173149	NEK6;NKX3-1
1523	Wnt signaling pathway (GO:0016055)	2/234	0.9584467	1	0	0	0.4079718	0.0173149	WNT16;CTHRC1
1524	negative regulation of cell growth (GO:0030308)	1/150	0.9587398	1	0	0	0.3182180	0.0134083	CGREF1
1525	single organismal cell-cell adhesion (GO:0016337)	2/235	0.9591806	1	0	0	0.4062357	0.0169302	CDSN;CEACAM5
1526	potassium ion transport (GO:0006813)	1/151	0.9596107	1	0	0	0.3161106	0.0130325	KCNN2
1527	activation of innate immune response (GO:0002218)	1/151	0.9596107	1	0	0	0.3161106	0.0130325	IRAK3
1528	negative regulation of immune system process (GO:0002683)	3/311	0.9600120	1	0	0	0.4604440	0.0187905	ZBTB16;IRAK3;THBS1
1529	peptidyl-tyrosine phosphorylation (GO:0018108)	1/152	0.9604633	1	0	0	0.3140309	0.0126679	NTRK2
1530	regulation of canonical Wnt signaling pathway (GO:0060828)	1/152	0.9604633	1	0	0	0.3140309	0.0126679	CTHRC1
1531	maintenance of location (GO:0051235)	1/152	0.9604633	1	0	0	0.3140309	0.0126679	FBN2
1532	receptor-mediated endocytosis (GO:0006898)	1/152	0.9604633	1	0	0	0.3140309	0.0126679	APOB
1533	muscle system process (GO:0003012)	2/237	0.9606113	1	0	0	0.4028076	0.0161870	EDN2;TNNI3
1534	regulation of homeostatic process (GO:0032844)	3/314	0.9618780	1	0	0	0.4560449	0.0177254	BMP8A;PTGS2;ADRA2A
1535	negative regulation of cell development (GO:0010721)	2/239	0.9619939	1	0	0	0.3994368	0.0154771	SIX3;PAX6
1536	peptidyl-tyrosine modification (GO:0018212)	1/154	0.9621149	1	0	0	0.3099526	0.0119708	NTRK2
1537	positive regulation of protein processing (GO:0010954)	2/240	0.9626676	1	0	0	0.3977725	0.0151341	ADRA2A;NKX3-1
1538	positive regulation of protein maturation (GO:1903319)	2/240	0.9626676	1	0	0	0.3977725	0.0151341	ADRA2A;NKX3-1
1539	mitotic nuclear division (GO:0007067)	2/240	0.9626676	1	0	0	0.3977725	0.0151341	NEK6;FIGN
1540	regulation of cellular protein catabolic process (GO:1903362)	1/155	0.9629147	1	0	0	0.3079529	0.0116377	NEK6
1541	cell cycle checkpoint (GO:0000075)	1/156	0.9636976	1	0	0	0.3059788	0.0113144	NEK6
1542	regulation of myeloid cell differentiation (GO:0045637)	1/156	0.9636976	1	0	0	0.3059788	0.0113144	ZBTB16
1543	negative regulation of phosphorus metabolic process (GO:0010563)	5/458	0.9649916	1	0	0	0.5210993	0.0185698	AHSG;GRM8;TNNI3;IRAK3;ADRA2A
1544	negative regulation of phosphate metabolic process (GO:0045936)	5/458	0.9649916	1	0	0	0.5210993	0.0185698	AHSG;GRM8;TNNI3;IRAK3;ADRA2A
1545	regulation of mitotic cell cycle (GO:0007346)	4/391	0.9654132	1	0	0	0.4883140	0.0171882	MUC1;BRINP1;NEK6;NKX3-1
1546	cellular response to hormone stimulus (GO:0032870)	5/462	0.9668704	1	0	0	0.5165876	0.0174043	STC1;APOB;ADRA2A;NKX3-1;CYP17A1
1547	small molecule biosynthetic process (GO:0044283)	4/394	0.9669123	1	0	0	0.4845959	0.0163054	EDN2;PYCR1;PTGS2;ALOX15B
1548	regulation of intracellular transport (GO:0032386)	4/394	0.9669123	1	0	0	0.4845959	0.0163054	CSF3;CHRM1;ADORA3;PTGS2
1549	endocytosis (GO:0006897)	3/323	0.9669972	1	0	0	0.4433377	0.0148783	AHSG;ELMOD1;APOB
1550	protein dephosphorylation (GO:0006470)	1/161	0.9673719	1	0	0	0.2964764	0.0098348	PTPRH
1551	cell-cell junction organization (GO:0045216)	1/161	0.9673719	1	0	0	0.2964764	0.0098348	CDH15
1552	regulation of cell morphogenesis involved in differentiation (GO:0010769)	2/248	0.9676601	1	0	0	0.3849411	0.0126547	NTRK2;CUX2
1553	morphogenesis of a branching epithelium (GO:0061138)	1/162	0.9680609	1	0	0	0.2946463	0.0095643	NKX3-1
1554	glycosaminoglycan metabolic process (GO:0030203)	1/162	0.9680609	1	0	0	0.2946463	0.0095643	SLC26A2
1555	developmental growth (GO:0048589)	1/163	0.9687355	1	0	0	0.2928386	0.0093016	PTHLH
1556	response to virus (GO:0009615)	2/250	0.9688041	1	0	0	0.3818616	0.0121023	IRAK3;APOB
1557	regulation of mitotic cell cycle phase transition (GO:1901990)	2/251	0.9693615	1	0	0	0.3803402	0.0118353	MUC1;NEK6
1558	rhythmic process (GO:0048511)	2/252	0.9699092	1	0	0	0.3788309	0.0115744	NTRK2;SIX3
1559	activation of protein kinase activity (GO:0032147)	2/252	0.9699092	1	0	0	0.3788309	0.0115744	THBS1;ADRA2A
1560	cellular carbohydrate metabolic process (GO:0044262)	1/165	0.9700422	1	0	0	0.2892891	0.0087989	HKDC1
1561	regulation of endocytosis (GO:0030100)	1/165	0.9700422	1	0	0	0.2892891	0.0087989	AHSG
1562	response to transforming growth factor beta (GO:0071559)	1/166	0.9706750	1	0	0	0.2875464	0.0085584	LEFTY1
1563	cellular response to transforming growth factor beta stimulus (GO:0071560)	1/166	0.9706750	1	0	0	0.2875464	0.0085584	LEFTY1
1564	organic hydroxy compound biosynthetic process (GO:1901617)	1/166	0.9706750	1	0	0	0.2875464	0.0085584	GPR37
1565	monocarboxylic acid metabolic process (GO:0032787)	5/473	0.9715686	1	0	0	0.5045740	0.0145536	EDN2;HKDC1;SLCO1B3;PTGS2;ALOX15B
1566	organ morphogenesis (GO:0009887)	4/405	0.9719072	1	0	0	0.4714340	0.0134335	COMP;LEFTY1;CDSN;PAX6
1567	epithelium development (GO:0060429)	2/256	0.9720074	1	0	0	0.3729117	0.0105877	CDSN;PTHLH
1568	positive regulation of protein serine/threonine kinase activity (GO:0071902)	2/257	0.9725095	1	0	0	0.3714607	0.0103546	THBS1;ADRA2A
1569	organic hydroxy compound metabolic process (GO:1901615)	5/476	0.9727386	1	0	0	0.5013939	0.0138585	TPO;GPR37;SLCO1B3;APOB;CYP17A1
1570	MAPK cascade (GO:0000165)	1/170	0.9730755	1	0	0	0.2807806	0.0076635	CDC42EP5
1571	morphogenesis of a branching structure (GO:0001763)	1/170	0.9730755	1	0	0	0.2807806	0.0076635	NKX3-1
1572	regulation of stress-activated MAPK cascade (GO:0032872)	1/170	0.9730755	1	0	0	0.2807806	0.0076635	WNT16
1573	regulation of cell morphogenesis (GO:0022604)	4/408	0.9731419	1	0	0	0.4679676	0.0127406	CCL24;NTRK2;CUX2;CDC42EP5
1574	regulation of cell adhesion (GO:0030155)	3/336	0.9732599	1	0	0	0.4261848	0.0115514	ADAMDEC1;C1QTNF1;THBS1
1575	single organism cell adhesion (GO:0098602)	2/259	0.9734878	1	0	0	0.3685923	0.0099041	CDSN;CEACAM5
1576	aminoglycan metabolic process (GO:0006022)	1/171	0.9736444	1	0	0	0.2791386	0.0074556	SLC26A2
1577	regulation of stress-activated protein kinase signaling cascade (GO:0070302)	1/171	0.9736444	1	0	0	0.2791386	0.0074556	WNT16
1578	positive regulation of cell adhesion (GO:0045785)	1/171	0.9736444	1	0	0	0.2791386	0.0074556	THBS1
1579	regulation of chromosome organization (GO:0033044)	1/172	0.9742013	1	0	0	0.2775157	0.0072535	MUC1
1580	regulation of cytokine production (GO:0001817)	5/482	0.9749458	1	0	0	0.4951525	0.0125637	IRAK3;PTGS2;ALOX15B;THBS1;ADRA2A
1581	reproductive structure development (GO:0048608)	2/265	0.9762254	1	0	0	0.3602468	0.0086682	ALOX15B;NKX3-1
1582	cellular amide metabolic process (GO:0043603)	1/177	0.9768143	1	0	0	0.2696763	0.0063262	CPE
1583	negative regulation of intracellular signal transduction (GO:1902532)	3/345	0.9769175	1	0	0	0.4150669	0.0096931	MUC1;IRAK3;THBS1
1584	regulation of cellular ketone metabolic process (GO:0010565)	1/178	0.9773044	1	0	0	0.2681612	0.0061562	PTGS2
1585	regulation of cell activation (GO:0050865)	4/420	0.9775904	1	0	0	0.4545971	0.0103032	C1QTNF1;ADORA3;ZBTB16;THBS1
1586	mitochondrion organization (GO:0007005)	1/179	0.9777841	1	0	0	0.2666631	0.0059910	BHLHA15
1587	protein catabolic process (GO:0030163)	2/269	0.9778966	1	0	0	0.3548899	0.0079323	PRSS16;APOB
1588	multicellular organismal reproductive process (GO:0048609)	5/491	0.9779472	1	0	0	0.4860763	0.0108393	CATSPERB;PTGS2;APOB;FOXA3;CYP17A1
1589	locomotory behavior (GO:0007626)	1/183	0.9796038	1	0	0	0.2608344	0.0053750	PCDH15
1590	spermatogenesis (GO:0007283)	3/353	0.9797652	1	0	0	0.4056603	0.0082927	CATSPERB;APOB;FOXA3
1591	male gamete generation (GO:0048232)	3/354	0.9800967	1	0	0	0.4045144	0.0081324	CATSPERB;APOB;FOXA3
1592	regulation of neuron projection development (GO:0010975)	2/275	0.9801922	1	0	0	0.3471469	0.0069452	NTRK2;CUX2
1593	antigen processing and presentation of peptide antigen (GO:0048002)	1/185	0.9804571	1	0	0	0.2580146	0.0050923	AZGP1
1594	DNA replication (GO:0006260)	1/186	0.9808703	1	0	0	0.2566274	0.0049568	ADRA2A
1595	intracellular receptor signaling pathway (GO:0030522)	1/186	0.9808703	1	0	0	0.2566274	0.0049568	NKX3-1
1596	positive regulation of cell cycle (GO:0045787)	2/278	0.9812518	1	0	0	0.3434007	0.0064993	MUC1;NKX3-1
1597	brain development (GO:0007420)	1/187	0.9812747	1	0	0	0.2552551	0.0048250	SIX3
1598	tissue morphogenesis (GO:0048729)	3/358	0.9813716	1	0	0	0.3999947	0.0075215	PCDH15;TNNI3;NKX3-1
1599	regulation of neuron apoptotic process (GO:0043523)	1/188	0.9816707	1	0	0	0.2538973	0.0046969	NTRK2
1600	positive regulation of growth (GO:0045927)	1/189	0.9820583	1	0	0	0.2525540	0.0045724	TFCP2L1
1601	positive regulation of T cell activation (GO:0050870)	1/189	0.9820583	1	0	0	0.2525540	0.0045724	ZBTB16
1602	negative regulation of protein kinase activity (GO:0006469)	1/189	0.9820583	1	0	0	0.2525540	0.0045724	IRAK3
1603	positive regulation of innate immune response (GO:0045089)	1/190	0.9824377	1	0	0	0.2512247	0.0044513	IRAK3
1604	cellular component morphogenesis (GO:0032989)	4/437	0.9827203	1	0	0	0.4369126	0.0076157	STC1;TFCP2L1;SHROOM1;WNT16
1605	response to peptide hormone (GO:0043434)	3/364	0.9831391	1	0	0	0.3934013	0.0066897	HSD11B2;TFF1;PLAT
1606	negative regulation of mitotic cell cycle phase transition (GO:1901991)	1/192	0.9831727	1	0	0	0.2486078	0.0042190	MUC1
1607	small GTPase mediated signal transduction (GO:0007264)	4/439	0.9832450	1	0	0	0.4349221	0.0073489	RAB43;ARHGAP40;CDC42EP5;ADRA2A
1608	transmembrane receptor protein serine/threonine kinase signaling pathway (GO:0007178)	1/196	0.9845518	1	0	0	0.2435342	0.0037915	LEFTY1
1609	coenzyme metabolic process (GO:0006732)	1/196	0.9845518	1	0	0	0.2435342	0.0037915	ALDH1L2
1610	carboxylic acid catabolic process (GO:0046395)	1/200	0.9858182	1	0	0	0.2386635	0.0034089	ALDH1L2
1611	organic acid catabolic process (GO:0016054)	1/200	0.9858182	1	0	0	0.2386635	0.0034089	ALDH1L2
1612	negative regulation of cell cycle phase transition (GO:1901988)	1/200	0.9858182	1	0	0	0.2386635	0.0034089	MUC1
1613	generation of precursor metabolites and energy (GO:0006091)	3/375	0.9859716	1	0	0	0.3818616	0.0053948	HKDC1;CACNA1E;ADRA2A
1614	negative regulation of kinase activity (GO:0033673)	1/202	0.9864119	1	0	0	0.2363005	0.0032329	IRAK3
1615	signal transduction by phosphorylation (GO:0023014)	1/202	0.9864119	1	0	0	0.2363005	0.0032329	CDC42EP5
1616	morphogenesis of an epithelium (GO:0002009)	2/296	0.9865454	1	0	0	0.3225182	0.0043688	PCDH15;NKX3-1
1617	nuclear division (GO:0000280)	2/298	0.9870350	1	0	0	0.3203537	0.0041806	NEK6;FIGN
1618	response to peptide (GO:1901652)	3/384	0.9879443	1	0	0	0.3729117	0.0045230	HSD11B2;TFF1;PLAT
1619	nucleotide biosynthetic process (GO:0009165)	1/208	0.9880485	1	0	0	0.2294841	0.0027592	SLC26A2
1620	regulation of leukocyte differentiation (GO:1902105)	1/210	0.9885491	1	0	0	0.2272986	0.0026178	ZBTB16
1621	nitrogen compound transport (GO:0071705)	4/464	0.9886529	1	0	0	0.4114888	0.0046959	NTRK2;TCN1;ADORA3;SLC6A1
1622	regulation of leukocyte activation (GO:0002694)	3/390	0.9891084	1	0	0	0.3671746	0.0040210	ADORA3;ZBTB16;THBS1
1623	gamete generation (GO:0007276)	3/390	0.9891084	1	0	0	0.3671746	0.0040210	CATSPERB;APOB;FOXA3
1624	cell projection assembly (GO:0030031)	1/213	0.9892610	1	0	0	0.2240972	0.0024196	PCDH15
1625	regulation of cell projection organization (GO:0031344)	3/391	0.9892916	1	0	0	0.3662355	0.0039429	NTRK2;CUX2;CDC42EP5
1626	positive regulation of sequence-specific DNA binding transcription factor activity (GO:0051091)	1/214	0.9894884	1	0	0	0.2230500	0.0023570	IRAK3
1627	transcription from RNA polymerase II promoter (GO:0006366)	4/470	0.9896779	1	0	0	0.4062357	0.0042150	SIX3;PAX6;SPDEF;NKX3-1
1628	sulfur compound metabolic process (GO:0006790)	2/314	0.9903742	1	0	0	0.3040299	0.0029407	SULT1C2;SLC26A2
1629	positive regulation of cell cycle process (GO:0090068)	1/220	0.9907551	1	0	0	0.2169668	0.0020152	MUC1
1630	protein folding (GO:0006457)	1/221	0.9909508	1	0	0	0.2159851	0.0019634	FKBP5
1631	in utero embryonic development (GO:0001701)	1/222	0.9911425	1	0	0	0.2150121	0.0019130	APOB
1632	antigen processing and presentation (GO:0019882)	1/225	0.9916935	1	0	0	0.2121453	0.0017696	AZGP1
1633	response to light stimulus (GO:0009416)	2/322	0.9917129	1	0	0	0.2964764	0.0024672	APOB;PTGS2
1634	chordate embryonic development (GO:0043009)	1/226	0.9918694	1	0	0	0.2112066	0.0017243	APOB
1635	negative regulation of phosphorylation (GO:0042326)	2/325	0.9921666	1	0	0	0.2937397	0.0023101	AHSG;IRAK3
1636	organelle fission (GO:0048285)	2/325	0.9921666	1	0	0	0.2937397	0.0023101	NEK6;FIGN
1637	cellular process involved in reproduction in multicellular organism (GO:0022412)	1/228	0.9922102	1	0	0	0.2093539	0.0016372	ZBTB16
1638	embryo development ending in birth or egg hatching (GO:0009792)	1/230	0.9925368	1	0	0	0.2075335	0.0015547	APOB
1639	nucleic acid phosphodiester bond hydrolysis (GO:0090305)	1/230	0.9925368	1	0	0	0.2075335	0.0015547	AZGP1
1640	cellular response to abiotic stimulus (GO:0071214)	1/232	0.9928497	1	0	0	0.2057444	0.0014764	PTGS2
1641	regulation of protein serine/threonine kinase activity (GO:0071900)	3/416	0.9930174	1	0	0	0.3442262	0.0024120	IRAK3;THBS1;ADRA2A
1642	cellular amino acid metabolic process (GO:0006520)	3/421	0.9935946	1	0	0	0.3401380	0.0021857	TPO;PYCR1;ALDH1L2
1643	regulation of sequence-specific DNA binding transcription factor activity (GO:0051090)	2/338	0.9938674	1	0	0	0.2824420	0.0017374	IRAK3;PTHLH
1644	alcohol metabolic process (GO:0006066)	2/340	0.9940947	1	0	0	0.2807806	0.0016630	APOB;CYP17A1
1645	GTP catabolic process (GO:0006184)	1/243	0.9943507	1	0	0	0.1964309	0.0011129	RAB43
1646	positive regulation of lymphocyte activation (GO:0051251)	1/243	0.9943507	1	0	0	0.1964309	0.0011129	ZBTB16
1647	microtubule cytoskeleton organization (GO:0000226)	1/245	0.9945876	1	0	0	0.1948273	0.0010573	NEK6
1648	guanosine-containing compound catabolic process (GO:1901069)	1/246	0.9947024	1	0	0	0.1940354	0.0010307	RAB43
1649	response to insulin (GO:0032868)	1/246	0.9947024	1	0	0	0.1940354	0.0010307	HSD11B2
1650	regulation of Ras GTPase activity (GO:0032318)	2/349	0.9950197	1	0	0	0.2735398	0.0013657	CCL24;NTRK2
1651	cellular component disassembly (GO:0022411)	2/350	0.9951133	1	0	0	0.2727583	0.0013362	FBN2;NEK6
1652	leukocyte differentiation (GO:0002521)	1/251	0.9952406	1	0	0	0.1901701	0.0009072	CSF3
1653	inorganic cation transmembrane transport (GO:0098662)	3/440	0.9953955	1	0	0	0.3254502	0.0015020	JPH2;KCNN2;CACNA1E
1654	regulation of innate immune response (GO:0045088)	1/254	0.9955370	1	0	0	0.1879240	0.0008406	IRAK3
1655	negative regulation of cell cycle process (GO:0010948)	1/254	0.9955370	1	0	0	0.1879240	0.0008406	MUC1
1656	response to radiation (GO:0009314)	3/442	0.9955537	1	0	0	0.3239776	0.0014437	PTGS2;APOB;CYP17A1
1657	cofactor metabolic process (GO:0051186)	1/255	0.9956317	1	0	0	0.1871870	0.0008195	ALDH1L2
1658	regulation of small GTPase mediated signal transduction (GO:0051056)	1/256	0.9957243	1	0	0	0.1864558	0.0007989	ARHGAP40
1659	GTP metabolic process (GO:0046039)	1/258	0.9959038	1	0	0	0.1850105	0.0007594	RAB43
1660	regulation of T cell activation (GO:0050863)	1/259	0.9959906	1	0	0	0.1842961	0.0007404	ZBTB16
1661	negative regulation of protein phosphorylation (GO:0001933)	1/260	0.9960757	1	0	0	0.1835873	0.0007219	IRAK3
1662	small molecule catabolic process (GO:0044282)	1/261	0.9961589	1	0	0	0.1828839	0.0007038	ALDH1L2
1663	protein oligomerization (GO:0051259)	2/366	0.9963958	1	0	0	0.2608344	0.0009418	C1QTNF1;SLC6A1
1664	regulation of translation (GO:0006417)	1/264	0.9963982	1	0	0	0.1808057	0.0006524	THBS1
1665	positive regulation of protein kinase activity (GO:0045860)	3/456	0.9965219	1	0	0	0.3140309	0.0010941	THBS1;ADRA2A;NKX3-1
1666	methylation (GO:0032259)	1/269	0.9967644	1	0	0	0.1774450	0.0005751	ALDH1L2
1667	guanosine-containing compound metabolic process (GO:1901068)	1/269	0.9967644	1	0	0	0.1774450	0.0005751	RAB43
1668	carbohydrate derivative biosynthetic process (GO:1901137)	2/377	0.9970793	1	0	0	0.2532239	0.0007407	SLC26A2;B3GNT6
1669	neurotrophin TRK receptor signaling pathway (GO:0048011)	1/274	0.9970934	1	0	0	0.1742069	0.0005071	NTRK2
1670	embryo development (GO:0009790)	1/276	0.9972154	1	0	0	0.1729446	0.0004822	APOB
1671	protein localization to membrane (GO:0072657)	1/276	0.9972154	1	0	0	0.1729446	0.0004822	CPE
1672	neurotrophin signaling pathway (GO:0038179)	1/278	0.9973324	1	0	0	0.1717003	0.0004586	NTRK2
1673	dephosphorylation (GO:0016311)	1/278	0.9973324	1	0	0	0.1717003	0.0004586	PTPRH
1674	monovalent inorganic cation transport (GO:0015672)	2/384	0.9974461	1	0	0	0.2486078	0.0006357	KCNN2;SLC13A5
1675	negative regulation of transferase activity (GO:0051348)	1/284	0.9976546	1	0	0	0.1680729	0.0003947	IRAK3
1676	positive regulation of kinase activity (GO:0033674)	3/480	0.9977258	1	0	0	0.2983294	0.0006792	THBS1;ADRA2A;NKX3-1
1677	regulation of cell cycle process (GO:0010564)	3/481	0.9977659	1	0	0	0.2977091	0.0006658	MUC1;NEK6;SIX3
1678	positive regulation of GTPase activity (GO:0043547)	3/482	0.9978054	1	0	0	0.2970915	0.0006527	CCL24;ARHGAP40;ELMOD1
1679	positive regulation of GTP catabolic process (GO:0033126)	3/483	0.9978441	1	0	0	0.2964764	0.0006399	CCL24;ARHGAP40;ELMOD1
1680	phospholipid metabolic process (GO:0006644)	1/288	0.9978475	1	0	0	0.1657385	0.0003571	LIPG
1681	protein localization to organelle (GO:0033365)	2/396	0.9979723	1	0	0	0.2410742	0.0004893	ZBTB16;PAX6
1682	positive regulation of Ras GTPase activity (GO:0032320)	1/292	0.9980245	1	0	0	0.1634681	0.0003233	CCL24
1683	glycerolipid metabolic process (GO:0046486)	1/296	0.9981870	1	0	0	0.1612591	0.0002926	APOB
1684	cellular response to organonitrogen compound (GO:0071417)	2/411	0.9984821	1	0	0	0.2322759	0.0003528	STC1;PTGS2
1685	regulation of multi-organism process (GO:0043900)	1/306	0.9985371	1	0	0	0.1559892	0.0002284	PLAT
1686	nucleoside monophosphate metabolic process (GO:0009123)	2/427	0.9988868	1	0	0	0.2235724	0.0002490	RTEL1-TNFRSF6B;ENTPD8
1687	regulation of cell growth (GO:0001558)	1/322	0.9989623	1	0	0	0.1482382	0.0001539	CGREF1
1688	organophosphate biosynthetic process (GO:0090407)	2/436	0.9990655	1	0	0	0.2189573	0.0002047	SLC26A2;ENTPD8
1689	ATP catabolic process (GO:0006200)	1/327	0.9990679	1	0	0	0.1459716	0.0001361	RTEL1-TNFRSF6B
1690	cellular response to nitrogen compound (GO:1901699)	2/438	0.9991012	1	0	0	0.2179575	0.0001960	STC1;PTGS2
1691	purine ribonucleoside monophosphate catabolic process (GO:0009169)	1/332	0.9991627	1	0	0	0.1437732	0.0001204	RTEL1-TNFRSF6B
1692	ribonucleoside monophosphate catabolic process (GO:0009158)	1/332	0.9991627	1	0	0	0.1437732	0.0001204	RTEL1-TNFRSF6B
1693	purine nucleoside monophosphate catabolic process (GO:0009128)	1/333	0.9991805	1	0	0	0.1433414	0.0001175	RTEL1-TNFRSF6B
1694	nucleoside monophosphate catabolic process (GO:0009125)	1/335	0.9992149	1	0	0	0.1424857	0.0001119	RTEL1-TNFRSF6B
1695	regulation of lymphocyte activation (GO:0051249)	1/344	0.9993527	1	0	0	0.1387578	0.0000898	ZBTB16
1696	response to other organism (GO:0051707)	2/462	0.9994372	1	0	0	0.2066351	0.0001163	IRAK3;APOB
1697	negative regulation of cellular component organization (GO:0051129)	2/474	0.9995549	1	0	0	0.2014038	0.0000897	IRAK3;THBS1
1698	leukocyte activation (GO:0045321)	1/373	0.9996522	1	0	0	0.1279697	0.0000445	EDN2
1699	ATP metabolic process (GO:0046034)	1/377	0.9996807	1	0	0	0.1266119	0.0000404	RTEL1-TNFRSF6B
1700	single-organism cellular localization (GO:1902580)	2/496	0.9997107	1	0	0	0.1924706	0.0000557	CPE;BHLHA15
1701	purine ribonucleoside monophosphate metabolic process (GO:0009167)	1/402	0.9998126	1	0	0	0.1187381	0.0000223	RTEL1-TNFRSF6B
1702	purine nucleoside monophosphate metabolic process (GO:0009126)	1/403	0.9998165	1	0	0	0.1184434	0.0000217	RTEL1-TNFRSF6B
1703	mitotic cell cycle (GO:0000278)	1/404	0.9998204	1	0	0	0.1181502	0.0000212	NEK6
1704	negative regulation of protein modification process (GO:0031400)	1/407	0.9998314	1	0	0	0.1172794	0.0000198	IRAK3
1705	ribonucleoside monophosphate metabolic process (GO:0009161)	1/416	0.9998607	1	0	0	0.1147421	0.0000160	RTEL1-TNFRSF6B
1706	microtubule-based process (GO:0007017)	1/437	0.9999103	1	0	0	0.1092281	0.0000098	NEK6
1707	posttranscriptional regulation of gene expression (GO:0010608)	1/438	0.9999122	1	0	0	0.1089788	0.0000096	THBS1
1708	immune response-activating signal transduction (GO:0002757)	1/440	0.9999158	1	0	0	0.1084834	0.0000091	IRAK3
1709	detection of chemical stimulus involved in sensory perception (GO:0050907)	1/465	0.9999496	1	0	0	0.1026510	0.0000052	AZGP1
1710	chromatin modification (GO:0016568)	1/475	0.9999588	1	0	0	0.1004899	0.0000041	FOXA3
1711	activation of immune response (GO:0002253)	1/487	0.9999674	1	0	0	0.0980138	0.0000032	IRAK3
1712	detection of chemical stimulus (GO:0009593)	1/499	0.9999741	1	0	0	0.0956567	0.0000025	AZGP1

GO_Cellular_Component_2015

go_cellular %>%
  knitr::kable(
    format = "html", align = rep("c", ncol(go_cellular) + 1),
    row.names = TRUE
  ) %>%
  kableExtra::kable_styling() %>%
  kableExtra::scroll_box(height = "300px")

	Term	Overlap	P.value	Adjusted.P.value	Old.P.value	Old.Adjusted.P.value	Odds.Ratio	Combined.Score	Genes
1	fibril (GO:0043205)	2/13	0.0293193	1	0	0	7.3434918	25.9189276	FBN2;MUC5AC
2	extracellular space (GO:0005615)	32/1120	0.0469779	1	0	0	1.3637913	4.1705816	CSF3;PCDH15;STC1;PLAT;MSLN;CXCL2;THBS1;PTHLH;COMP;TPO;MUC1;C1QTNF1;LIPG;APOB;CTHRC1;SERPINB4;CCL24;LEFTY1;EDN2;AHSG;BMP8A;IL19;WNT16;F5;AZGP1;TCN1;PXDN;HMSD;LCN2;SSPO;TFF1;PKHD1L1
3	Golgi lumen (GO:0005796)	4/86	0.1065052	1	0	0	2.2201254	4.9721080	MUC1;MUC3A;MUC5AC;MUC6
4	troponin complex (GO:0005861)	1/8	0.1558373	1	0	0	5.9665871	11.0915436	TNNI3
5	fibrinogen complex (GO:0005577)	1/8	0.1558373	1	0	0	5.9665871	11.0915436	THBS1
6	asymmetric synapse (GO:0032279)	1/8	0.1558373	1	0	0	5.9665871	11.0915436	CHRM1
7	microfibril (GO:0001527)	1/9	0.1735296	1	0	0	5.3036330	9.2888214	FBN2
8	CatSper complex (GO:0036128)	1/9	0.1735296	1	0	0	5.3036330	9.2888214	CATSPERB
9	voltage-gated calcium channel complex (GO:0005891)	2/38	0.1889323	1	0	0	2.5122472	4.1863248	CATSPERB;CACNA1E
10	junctional sarcoplasmic reticulum membrane (GO:0014701)	1/10	0.1908519	1	0	0	4.7732697	7.9057641	JPH2
11	vesicle lumen (GO:0031983)	3/76	0.2132832	1	0	0	1.8841854	2.9113198	APOB;THBS1;F5
12	cytoplasmic membrane-bounded vesicle lumen (GO:0060205)	3/76	0.2132832	1	0	0	1.8841854	2.9113198	APOB;THBS1;F5
13	endosome lumen (GO:0031904)	1/12	0.2244175	1	0	0	3.9777247	5.9437046	APOB
14	chylomicron (GO:0042627)	1/13	0.2406756	1	0	0	3.6717459	5.2296866	APOB
15	MHC class I protein complex (GO:0042612)	1/13	0.2406756	1	0	0	3.6717459	5.2296866	AZGP1
16	platelet alpha granule (GO:0031091)	1/13	0.2406756	1	0	0	3.6717459	5.2296866	THBS1
17	Golgi cisterna membrane (GO:0032580)	1/14	0.2565938	1	0	0	3.4094783	4.6377803	FUT6
18	low-density lipoprotein particle (GO:0034362)	1/14	0.2565938	1	0	0	3.4094783	4.6377803	APOB
19	smooth endoplasmic reticulum (GO:0005790)	1/14	0.2565938	1	0	0	3.4094783	4.6377803	KCNN2
20	platelet alpha granule lumen (GO:0031093)	2/48	0.2663018	1	0	0	1.9888624	2.6315136	THBS1;F5
21	extracellular matrix part (GO:0044420)	4/127	0.2761944	1	0	0	1.5033920	1.9343398	FBN2;ENTPD2;NID2;MUC5AC
22	basal lamina (GO:0005605)	1/16	0.2874383	1	0	0	2.9832936	3.7194122	ENTPD2
23	endocytic vesicle lumen (GO:0071682)	1/16	0.2874383	1	0	0	2.9832936	3.7194122	APOB
24	extracellular matrix (GO:0031012)	9/348	0.3076000	1	0	0	1.2344663	1.4553804	COMP;FBN2;PXDN;CHAD;PLAT;WNT16;NID2;THBS1;CTHRC1
25	neuronal postsynaptic density (GO:0097481)	1/18	0.3170060	1	0	0	2.6518165	3.0464985	NTRK2
26	mast cell granule (GO:0042629)	1/18	0.3170060	1	0	0	2.6518165	3.0464985	ADORA3
27	desmosome (GO:0030057)	1/19	0.3313276	1	0	0	2.5122472	2.7751481	CDSN
28	excitatory synapse (GO:0060076)	1/19	0.3313276	1	0	0	2.5122472	2.7751481	NTRK2
29	stereocilium (GO:0032420)	1/19	0.3313276	1	0	0	2.5122472	2.7751481	PCDH15
30	calcium channel complex (GO:0034704)	2/57	0.3360828	1	0	0	1.6748315	1.8262323	CATSPERB;CACNA1E
31	very-low-density lipoprotein particle (GO:0034361)	1/20	0.3453496	1	0	0	2.3866348	2.5374656	APOB
32	triglyceride-rich lipoprotein particle (GO:0034385)	1/20	0.3453496	1	0	0	2.3866348	2.5374656	APOB
33	costamere (GO:0043034)	1/21	0.3590782	1	0	0	2.2729856	2.3280260	FLNC
34	secretory granule lumen (GO:0034774)	2/62	0.3740573	1	0	0	1.5397644	1.5141217	THBS1;F5
35	proteinaceous extracellular matrix (GO:0005578)	6/239	0.3852649	1	0	0	1.1983104	1.1429775	COMP;FBN2;PXDN;CHAD;WNT16;CTHRC1
36	cornified envelope (GO:0001533)	1/23	0.3856798	1	0	0	2.0753346	1.9772706	CDSN
37	sarcoplasmic reticulum membrane (GO:0033017)	1/23	0.3856798	1	0	0	2.0753346	1.9772706	JPH2
38	synapse (GO:0045202)	6/243	0.4002119	1	0	0	1.1785851	1.0793025	NTRK2;CHRM1;PCDH15;PLAT;CDH15;ADRA2A
39	presynaptic active zone (GO:0048786)	1/25	0.4111798	1	0	0	1.9093079	1.6968492	NTRK2
40	myosin II complex (GO:0016460)	1/25	0.4111798	1	0	0	1.9093079	1.6968492	SHROOM1
41	dendritic spine (GO:0043197)	2/71	0.4399794	1	0	0	1.3445830	1.1039396	NTRK2;KCNN2
42	MHC protein complex (GO:0042611)	1/29	0.4590552	1	0	0	1.6459551	1.2815157	AZGP1
43	neuron spine (GO:0044309)	2/74	0.4611076	1	0	0	1.2900729	0.9986763	NTRK2;KCNN2
44	contractile fiber part (GO:0044449)	4/167	0.4646495	1	0	0	1.1432981	0.8763060	JPH2;KCNN2;TNNI3;FLNC
45	clathrin-coated endocytic vesicle membrane (GO:0030669)	1/31	0.4815161	1	0	0	1.5397644	1.1252839	APOB
46	integrin complex (GO:0008305)	1/31	0.4815161	1	0	0	1.5397644	1.1252839	ITGA10
47	sarcomere (GO:0030017)	1/31	0.4815161	1	0	0	1.5397644	1.1252839	TNNI3
48	protein complex involved in cell adhesion (GO:0098636)	1/31	0.4815161	1	0	0	1.5397644	1.1252839	ITGA10
49	photoreceptor outer segment (GO:0001750)	1/34	0.5134749	1	0	0	1.4039028	0.9357774	PCDH15
50	axon terminus (GO:0043679)	1/34	0.5134749	1	0	0	1.4039028	0.9357774	CHRM1
51	SNARE complex (GO:0031201)	1/35	0.5236849	1	0	0	1.3637913	0.8821891	DOC2B
52	T-tubule (GO:0030315)	1/36	0.5336812	1	0	0	1.3259082	0.8326130	KCNN2
53	synaptic vesicle (GO:0008021)	2/86	0.5406975	1	0	0	1.1100627	0.6825724	DOC2B;SYT8
54	Z disc (GO:0030018)	2/87	0.5469535	1	0	0	1.0973034	0.6621035	JPH2;KCNN2
55	plasma lipoprotein particle (GO:0034358)	1/38	0.5530502	1	0	0	1.2561236	0.7440102	APOB
56	basolateral plasma membrane (GO:0016323)	3/138	0.5548702	1	0	0	1.0376673	0.6112080	CEACAM5;SLC13A5;ADRA2A
57	terminal bouton (GO:0043195)	1/39	0.5624316	1	0	0	1.2239153	0.7043459	NTRK2
58	collagen trimer (GO:0005581)	2/91	0.5713775	1	0	0	1.0490703	0.5871700	C1QTNF1;CTHRC1
59	protein-lipid complex (GO:0032994)	1/40	0.5716165	1	0	0	1.1933174	0.6674069	APOB
60	sarcoplasmic reticulum (GO:0016529)	1/40	0.5716165	1	0	0	1.1933174	0.6674069	THBS1
61	presynaptic membrane (GO:0042734)	1/44	0.6064726	1	0	0	1.0848340	0.5425209	GRM8
62	phagocytic vesicle (GO:0045335)	1/44	0.6064726	1	0	0	1.0848340	0.5425209	RAB43
63	neuron projection terminus (GO:0044306)	1/44	0.6064726	1	0	0	1.0848340	0.5425209	CHRM1
64	postsynaptic density (GO:0014069)	2/98	0.6117869	1	0	0	0.9741367	0.4786628	NTRK2;CHRM1
65	neuromuscular junction (GO:0031594)	1/47	0.6307446	1	0	0	1.0155893	0.4680387	CDH15
66	clathrin-coated vesicle membrane (GO:0030665)	1/48	0.6384987	1	0	0	0.9944312	0.4461373	APOB
67	chloride channel complex (GO:0034707)	1/50	0.6535229	1	0	0	0.9546539	0.4060885	ANO1
68	axon (GO:0030424)	3/161	0.6589222	1	0	0	0.8894291	0.3710251	OMP;SLC6A1;CYP17A1
69	secretory granule membrane (GO:0030667)	1/54	0.6817282	1	0	0	0.8839388	0.3386584	CPE
70	plasma membrane raft (GO:0044853)	1/58	0.7076424	1	0	0	0.8229775	0.2845991	CDH15
71	caveola (GO:0005901)	1/58	0.7076424	1	0	0	0.8229775	0.2845991	CDH15
72	recycling endosome (GO:0055037)	1/60	0.7197990	1	0	0	0.7955449	0.2615619	REP15
73	plasma membrane region (GO:0098590)	7/395	0.7243853	1	0	0	0.8458959	0.2727438	ANO1;MUC1;CEACAM5;STC1;CDH15;SLC13A5;ADRA2A
74	microvillus (GO:0005902)	1/61	0.7256868	1	0	0	0.7825032	0.2508993	PCDH15
75	sarcolemma (GO:0042383)	1/63	0.7370948	1	0	0	0.7576619	0.2311162	FLNC
76	myosin complex (GO:0016459)	1/64	0.7426200	1	0	0	0.7458234	0.2219352	SHROOM1
77	nuclear matrix (GO:0016363)	1/64	0.7426200	1	0	0	0.7458234	0.2219352	FIGN
78	extracellular region (GO:0005576)	30/1585	0.7466204	1	0	0	0.9034580	0.2639889	FBN2;ADAMDEC1;CSF3;PLAT;NID2;CXCL2;THBS1;ABO;PTHLH;COMP;LIPG;CREG2;APOB;MUC6;SERPINB4;CGREF1;EDN2;AHSG;IL1R2;REG4;IL19;WNT16;MUC3A;F5;AZGP1;TCN1;ADM2;BPIFB6;LCN2;KCP
79	coated vesicle membrane (GO:0030662)	1/66	0.7533254	1	0	0	0.7232227	0.2048586	APOB
80	nonmotile primary cilium (GO:0031513)	1/67	0.7585103	1	0	0	0.7124283	0.1969144	PCDH15
81	PML body (GO:0016605)	1/68	0.7635865	1	0	0	0.7019514	0.1893366	ZBTB16
82	axon part (GO:0033267)	2/133	0.7708418	1	0	0	0.7177849	0.1868194	NTRK2;CHRM1
83	transcriptional repressor complex (GO:0017053)	1/70	0.7734217	1	0	0	0.6818957	0.1752000	ZBTB16
84	apical plasma membrane (GO:0016324)	3/201	0.7957327	1	0	0	0.7124283	0.1627841	ANO1;MUC1;STC1
85	basement membrane (GO:0005604)	1/77	0.8047394	1	0	0	0.6199052	0.1346662	NID2
86	cell surface (GO:0009986)	7/437	0.8128618	1	0	0	0.7645970	0.1584201	NTRK2;MUC1;PLAT;SLC6A1;MSLN;NID2;THBS1
87	cation channel complex (GO:0034703)	2/147	0.8166169	1	0	0	0.6494244	0.1315638	CATSPERB;CACNA1E
88	neuronal cell body (GO:0043025)	4/270	0.8202560	1	0	0	0.7071511	0.1401141	NTRK2;OMP;KCNN2;CYP17A1
89	receptor complex (GO:0043235)	4/272	0.8246228	1	0	0	0.7019514	0.1353567	NTRK2;GPR37;ITGA10;ADRA2A
90	anchored component of membrane (GO:0031225)	2/150	0.8252959	1	0	0	0.6364360	0.1222042	CEACAM5;MSLN
91	nuclear speck (GO:0016607)	1/84	0.8317373	1	0	0	0.5682464	0.1046930	ZBTB16
92	apical part of cell (GO:0045177)	1/87	0.8421357	1	0	0	0.5486517	0.0942661	PLAT
93	synaptic membrane (GO:0097060)	3/228	0.8595501	1	0	0	0.6280618	0.0950547	NTRK2;CHRM1;GRM8
94	endocytic vesicle membrane (GO:0030666)	1/94	0.8639732	1	0	0	0.5077946	0.0742465	APOB
95	endocytic vesicle (GO:0030139)	1/96	0.8696394	1	0	0	0.4972156	0.0694494	RAB43
96	primary cilium (GO:0072372)	1/99	0.8777003	1	0	0	0.4821485	0.0628963	PCDH15
97	growth cone (GO:0030426)	1/99	0.8777003	1	0	0	0.4821485	0.0628963	NTRK2
98	endosome membrane (GO:0010008)	2/175	0.8843850	1	0	0	0.5455165	0.0670237	REP15;APOB
99	site of polarized growth (GO:0030427)	1/102	0.8852638	1	0	0	0.4679676	0.0570310	NTRK2
100	secretory granule (GO:0030141)	2/176	0.8863125	1	0	0	0.5424170	0.0654620	PLAT;THBS1
101	nuclear chromatin (GO:0000790)	2/177	0.8882102	1	0	0	0.5393525	0.0639385	MUC1;PAX6
102	cell body (GO:0044297)	4/315	0.8991009	1	0	0	0.6061295	0.0644679	NTRK2;OMP;KCNN2;CYP17A1
103	peroxisome (GO:0005777)	1/109	0.9011464	1	0	0	0.4379147	0.0455814	SERHL2
104	ion channel complex (GO:0034702)	3/258	0.9093509	1	0	0	0.5550314	0.0527414	ANO1;CATSPERB;CACNA1E
105	endoplasmic reticulum membrane (GO:0005789)	6/449	0.9116705	1	0	0	0.6378534	0.0589866	JPH2;PTGS2;APOB;CYP3A5;FKBP5;CYP17A1
106	external side of plasma membrane (GO:0009897)	2/191	0.9118692	1	0	0	0.4998188	0.0461126	ANO1;THBS1
107	extrinsic component of membrane (GO:0019898)	1/115	0.9130018	1	0	0	0.4150669	0.0377783	ALOX15B
108	actin cytoskeleton (GO:0015629)	2/193	0.9148392	1	0	0	0.4946393	0.0440263	APOB;MYLK3
109	postsynaptic membrane (GO:0045211)	2/195	0.9177153	1	0	0	0.4895661	0.0420381	NTRK2;CHRM1
110	synapse part (GO:0044456)	5/395	0.9193926	1	0	0	0.6042114	0.0507791	NTRK2;CHRM1;GRM8;DOC2B;SYT8
111	endosomal part (GO:0044440)	2/200	0.9245113	1	0	0	0.4773270	0.0374654	REP15;APOB
112	microbody (GO:0042579)	1/123	0.9266318	1	0	0	0.3880707	0.0295706	SERHL2
113	transmembrane transporter complex (GO:1902495)	3/286	0.9407943	1	0	0	0.5006926	0.0305576	ANO1;CATSPERB;CACNA1E
114	transporter complex (GO:1990351)	3/291	0.9452165	1	0	0	0.4920897	0.0277250	ANO1;CATSPERB;CACNA1E
115	cytoplasmic membrane-bounded vesicle (GO:0016023)	6/492	0.9475602	1	0	0	0.5821061	0.0313550	RAB43;SERHL2;PLAT;DOC2B;SYT8;THBS1
116	cytoplasmic vesicle part (GO:0044433)	4/363	0.9480627	1	0	0	0.5259801	0.0280530	CPE;APOB;THBS1;F5
117	early endosome (GO:0005769)	1/141	0.9500087	1	0	0	0.3385298	0.0173612	APOB
118	cytoplasmic vesicle membrane (GO:0030659)	2/229	0.9545841	1	0	0	0.4168794	0.0193764	CPE;APOB
119	side of membrane (GO:0098552)	2/235	0.9591806	1	0	0	0.4062357	0.0169302	ANO1;THBS1
120	endoplasmic reticulum lumen (GO:0005788)	1/154	0.9621149	1	0	0	0.3099526	0.0119708	APOB
121	cilium (GO:0005929)	2/243	0.9646208	1	0	0	0.3928617	0.0141510	CATSPERB;PCDH15
122	blood microparticle (GO:0072562)	1/161	0.9673719	1	0	0	0.2964764	0.0098348	AHSG
123	vesicle membrane (GO:0012506)	2/249	0.9682370	1	0	0	0.3833952	0.0123754	CPE;APOB
124	lysosome (GO:0005764)	2/261	0.9744325	1	0	0	0.3657678	0.0094734	ADORA3;PRSS16
125	lytic vacuole (GO:0000323)	2/261	0.9744325	1	0	0	0.3657678	0.0094734	ADORA3;PRSS16
126	Golgi apparatus (GO:0005794)	11/865	0.9750118	1	0	0	0.6070054	0.0153607	RAB43;GOLGA7B;FUT6;GOLGA6B;CREG2;CPE;MSLN;APOB;ABO;JAKMIP3;PTHLH
127	ubiquitin ligase complex (GO:0000151)	1/183	0.9796038	1	0	0	0.2608344	0.0053750	GPR37
128	integral component of plasma membrane (GO:0005887)	14/1066	0.9798480	1	0	0	0.6268834	0.0127620	NTRK2;SLC26A2;GPR37;CHRM1;SLC6A1;PTPRH;ADRA2A;TPO;MUC1;C1QTNF1;ADORA3;CEACAM5;SLCO1B3;GRM8
129	microtubule (GO:0005874)	3/360	0.9819795	1	0	0	0.3977725	0.0072334	NEK6;FIGN;SHROOM1
130	chromatin (GO:0000785)	2/289	0.9846866	1	0	0	0.3303301	0.0050976	MUC1;PAX6
131	vacuole (GO:0005773)	2/293	0.9857773	1	0	0	0.3258205	0.0046673	ADORA3;PRSS16
132	membrane raft (GO:0045121)	1/200	0.9858182	1	0	0	0.2386635	0.0034089	CDH15
133	mitochondrial matrix (GO:0005759)	1/208	0.9880485	1	0	0	0.2294841	0.0027592	PYCR1
134	nuclear body (GO:0016604)	1/210	0.9885491	1	0	0	0.2272986	0.0026178	ZBTB16
135	Golgi membrane (GO:0000139)	2/308	0.9892340	1	0	0	0.3099526	0.0033550	FUT6;B3GNT6
136	nuclear chromosome part (GO:0044454)	2/327	0.9924554	1	0	0	0.2919431	0.0022109	MUC1;PAX6
137	dendrite (GO:0030425)	1/236	0.9934367	1	0	0	0.2022572	0.0013318	CHRM1
138	mitochondrial inner membrane (GO:0005743)	2/341	0.9942053	1	0	0	0.2799572	0.0016270	SLC25A48;SLC25A18
139	organelle inner membrane (GO:0019866)	2/360	0.9959591	1	0	0	0.2651816	0.0010737	SLC25A48;SLC25A18
140	anchoring junction (GO:0070161)	2/419	0.9986999	1	0	0	0.2278410	0.0002964	CDSN;FLNC
141	cell-cell junction (GO:0005911)	1/335	0.9992149	1	0	0	0.1424857	0.0001119	CDSN
142	mitochondrial membrane (GO:0031966)	2/457	0.9993794	1	0	0	0.2088958	0.0001297	SLC25A48;SLC25A18
143	focal adhesion (GO:0005925)	1/352	0.9994547	1	0	0	0.1356043	0.0000740	FLNC
144	cell-substrate adherens junction (GO:0005924)	1/358	0.9995205	1	0	0	0.1333316	0.0000639	FLNC
145	cell-substrate junction (GO:0030055)	1/362	0.9995599	1	0	0	0.1318583	0.0000580	FLNC
146	adherens junction (GO:0005912)	1/405	0.9998241	1	0	0	0.1178585	0.0000207	FLNC
147	perinuclear region of cytoplasm (GO:0048471)	1/411	0.9998451	1	0	0	0.1161379	0.0000180	REP15
148	intracellular (GO:0005622)	4/730	0.9998728	1	0	0	0.2615490	0.0000333	ARHGAP40;ANO7;ALOX15B;NKX3-1
149	extracellular vesicular exosome (GO:0070062)	31/2717	0.9999737	1	0	0	0.5446130	0.0000143	SLC26A2;CPNE4;SEMA3B;PCDH15;PLAT;ALDH1L2;NID2;THBS1;RAB43;COMP;FUT6;SULT1C2;MUC1;CUX2;APOB;SERPINB4;ENTPD2;CDSN;AHSG;ALOX15B;MUC5AC;ANO1;AZGP1;BPIFB2;CEACAM5;PXDN;LCN2;CPE;CDH15;FKBP5;AQP7P3
150	cytosol (GO:0005829)	12/2529	0.9999945	1	0	0	0.2264897	0.0000012	SULT1C2;NTRK2;ARHGAP40;ZBTB16;NEK6;HKDC1;TNNI3;FLNC;PKHD1L1;APOB;ALOX15B;MYLK3
151	nucleolus (GO:0005730)	3/1653	0.9999951	1	0	0	0.0866292	0.0000004	PHACTR3;PTHLH;FKBP5
152	mitochondrion (GO:0005739)	5/1269	0.9999954	1	0	0	0.1880721	0.0000009	TPO;PYCR1;SERHL2;ALDH1L2;CYP17A1

GO_Molecular_Function_2015

go_molecular %>%
  knitr::kable(
    format = "html", align = rep("c", ncol(go_molecular) + 1),
    row.names = TRUE
  ) %>%
  kableExtra::kable_styling() %>%
  kableExtra::scroll_box(height = "300px")

	Term	Overlap	P.value	Adjusted.P.value	Old.P.value	Old.Adjusted.P.value	Odds.Ratio	Combined.Score	Genes
1	extracellular matrix structural constituent (GO:0005201)	6/68	0.0029878	1	0	0	4.2117085	24.4835709	COMP;FBN2;PXDN;MUC3A;MUC5AC;MUC6
2	collagen binding (GO:0005518)	5/62	0.0095910	1	0	0	3.8494110	17.8879540	COMP;C1QTNF1;ITGA10;NID2;THBS1
3	intracellular calcium activated chloride channel activity (GO:0005229)	2/12	0.0251521	1	0	0	7.9554495	29.2984249	ANO1;ANO7
4	nucleoside-diphosphatase activity (GO:0017110)	2/13	0.0293193	1	0	0	7.3434918	25.9189276	ENTPD2;ENTPD8
5	ion gated channel activity (GO:0022839)	3/40	0.0509843	1	0	0	3.5799523	10.6547898	ANO1;KCNN2;ANO7
6	peroxidase activity (GO:0004601)	3/42	0.0574810	1	0	0	3.4094783	9.7384978	TPO;PXDN;PTGS2
7	oxidoreductase activity, acting on peroxide as acceptor (GO:0016684)	3/42	0.0574810	1	0	0	3.4094783	9.7384978	TPO;PXDN;PTGS2
8	oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor (GO:0016646)	2/19	0.0592174	1	0	0	5.0244944	14.2019371	PYCR1;ALDH1L2
9	phosphatidylserine binding (GO:0001786)	2/23	0.0829959	1	0	0	4.1506693	10.3308677	JPH2;THBS1
10	tetrapyrrole binding (GO:0046906)	6/146	0.0870458	1	0	0	1.9616177	4.7889376	TPO;TCN1;PXDN;PTGS2;CYP3A5;CYP17A1
11	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen (GO:0016702)	2/25	0.0958000	1	0	0	3.8186158	8.9565341	PTGS2;ALOX15B
12	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen (GO:0016701)	2/26	0.1023997	1	0	0	3.6717459	8.3674372	PTGS2;ALOX15B
13	calmodulin-dependent protein kinase activity (GO:0004683)	2/26	0.1023997	1	0	0	3.6717459	8.3674372	PNCK;MYLK3
14	proteoglycan binding (GO:0043394)	2/27	0.1091201	1	0	0	3.5357553	7.8327816	COMP;THBS1
15	oxidoreductase activity, acting on the CH-NH group of donors (GO:0016645)	2/28	0.1159532	1	0	0	3.4094783	7.3459547	PYCR1;ALDH1L2
16	organic acid:sodium symporter activity (GO:0005343)	2/28	0.1159532	1	0	0	3.4094783	7.3459547	SLC6A1;SLC13A5
17	calcium activated cation channel activity (GO:0005227)	2/29	0.1228915	1	0	0	3.2919101	6.9013369	ANO1;KCNN2
18	GPI anchor binding (GO:0034235)	1/8	0.1558373	1	0	0	5.9665871	11.0915436	CEACAM5
19	alpha-(1->3)-fucosyltransferase activity (GO:0046920)	1/8	0.1558373	1	0	0	5.9665871	11.0915436	FUT6
20	phospholipid scramblase activity (GO:0017128)	1/8	0.1558373	1	0	0	5.9665871	11.0915436	ANO7
21	AT DNA binding (GO:0003680)	1/8	0.1558373	1	0	0	5.9665871	11.0915436	PAX6
22	transcription corepressor binding (GO:0001222)	1/8	0.1558373	1	0	0	5.9665871	11.0915436	SIX3
23	phosphatidylinositol-5-phosphate binding (GO:0010314)	1/8	0.1558373	1	0	0	5.9665871	11.0915436	JPH2
24	hydroxymethyl-, formyl- and related transferase activity (GO:0016742)	1/8	0.1558373	1	0	0	5.9665871	11.0915436	ALDH1L2
25	ion channel inhibitor activity (GO:0008200)	2/34	0.1589105	1	0	0	2.8078057	5.1647173	ANKRD36C;TNNI3
26	galactosyltransferase activity (GO:0008378)	2/34	0.1589105	1	0	0	2.8078057	5.1647173	B3GNT6;ABO
27	heme binding (GO:0020037)	5/137	0.1608405	1	0	0	1.7420692	3.1833567	TPO;PXDN;PTGS2;CYP3A5;CYP17A1
28	channel inhibitor activity (GO:0016248)	2/35	0.1663335	1	0	0	2.7275827	4.8926297	ANKRD36C;TNNI3
29	heparin binding (GO:0008201)	5/140	0.1711062	1	0	0	1.7047392	3.0096678	COMP;REG4;LIPG;APOB;THBS1
30	neurotrophin binding (GO:0043121)	1/9	0.1735296	1	0	0	5.3036330	9.2888214	NTRK2
31	aldehyde-lyase activity (GO:0016832)	1/9	0.1735296	1	0	0	5.3036330	9.2888214	CYP17A1
32	protein binding involved in cell adhesion (GO:0098631)	1/9	0.1735296	1	0	0	5.3036330	9.2888214	ITGA10
33	adrenergic receptor activity (GO:0004935)	1/9	0.1735296	1	0	0	5.3036330	9.2888214	ADRA2A
34	cobalamin binding (GO:0031419)	1/9	0.1735296	1	0	0	5.3036330	9.2888214	TCN1
35	frizzled binding (GO:0005109)	2/36	0.1738152	1	0	0	2.6518165	4.6400487	WNT16;CTHRC1
36	antioxidant activity (GO:0016209)	3/70	0.1811279	1	0	0	2.0456870	3.4951626	TPO;PXDN;PTGS2
37	oxygen binding (GO:0019825)	2/37	0.1813500	1	0	0	2.5801458	4.4051511	CYP3A5;CYP17A1
38	transcription cofactor binding (GO:0001221)	1/10	0.1908519	1	0	0	4.7732697	7.9057641	SIX3
39	sodium:amino acid symporter activity (GO:0005283)	1/10	0.1908519	1	0	0	4.7732697	7.9057641	SLC6A1
40	GTP-Rho binding (GO:0017049)	1/10	0.1908519	1	0	0	4.7732697	7.9057641	CDC42EP5
41	sodium:dicarboxylate symporter activity (GO:0017153)	1/10	0.1908519	1	0	0	4.7732697	7.9057641	SLC13A5
42	semaphorin receptor binding (GO:0030215)	1/10	0.1908519	1	0	0	4.7732697	7.9057641	SEMA6B
43	RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity (GO:0000983)	1/10	0.1908519	1	0	0	4.7732697	7.9057641	NKX3-1
44	high voltage-gated calcium channel activity (GO:0008331)	1/10	0.1908519	1	0	0	4.7732697	7.9057641	CACNA1E
45	calcium channel inhibitor activity (GO:0019855)	1/11	0.2078120	1	0	0	4.3393361	6.8176239	TNNI3
46	receptor antagonist activity (GO:0048019)	1/11	0.2078120	1	0	0	4.3393361	6.8176239	PXDN
47	cholesterol transporter activity (GO:0017127)	1/11	0.2078120	1	0	0	4.3393361	6.8176239	APOB
48	secondary active sulfate transmembrane transporter activity (GO:0008271)	1/11	0.2078120	1	0	0	4.3393361	6.8176239	SLC26A2
49	phospholipid transporter activity (GO:0005548)	2/41	0.2119125	1	0	0	2.3284242	3.6127403	ATP10B;ANO7
50	G-protein coupled amine receptor activity (GO:0008227)	2/41	0.2119125	1	0	0	2.3284242	3.6127403	CHRM1;ADRA2A
51	thioesterase binding (GO:0031996)	1/12	0.2244175	1	0	0	3.9777247	5.9437046	ADRA2A
52	cation:amino acid symporter activity (GO:0005416)	1/12	0.2244175	1	0	0	3.9777247	5.9437046	SLC6A1
53	co-SMAD binding (GO:0070410)	1/12	0.2244175	1	0	0	3.9777247	5.9437046	PAX6
54	sterol transporter activity (GO:0015248)	1/12	0.2244175	1	0	0	3.9777247	5.9437046	APOB
55	receptor inhibitor activity (GO:0030547)	1/12	0.2244175	1	0	0	3.9777247	5.9437046	PXDN
56	low-density lipoprotein particle receptor binding (GO:0050750)	1/13	0.2406756	1	0	0	3.6717459	5.2296866	APOB
57	phosphatidylinositol-3,5-bisphosphate binding (GO:0080025)	1/13	0.2406756	1	0	0	3.6717459	5.2296866	JPH2
58	neurexin family protein binding (GO:0042043)	1/13	0.2406756	1	0	0	3.6717459	5.2296866	CPE
59	glycoprotein binding (GO:0001948)	3/81	0.2409331	1	0	0	1.7678777	2.5161070	COMP;AZGP1;THBS1
60	hormone activity (GO:0005179)	4/122	0.2530952	1	0	0	1.5650065	2.1503028	EDN2;ADM2;STC1;PTHLH
61	catecholamine binding (GO:1901338)	1/14	0.2565938	1	0	0	3.4094783	4.6377803	ADRA2A
62	sulfate transmembrane transporter activity (GO:0015116)	1/14	0.2565938	1	0	0	3.4094783	4.6377803	SLC26A2
63	fucosyltransferase activity (GO:0008417)	1/14	0.2565938	1	0	0	3.4094783	4.6377803	FUT6
64	phosphatidylinositol-4-phosphate binding (GO:0070273)	1/14	0.2565938	1	0	0	3.4094783	4.6377803	JPH2
65	chemokine activity (GO:0008009)	2/47	0.2585036	1	0	0	2.0311786	2.7478708	CCL24;CXCL2
66	anion:cation symporter activity (GO:0015296)	2/48	0.2663018	1	0	0	1.9888624	2.6315136	SLC6A1;SLC13A5
67	low-density lipoprotein particle binding (GO:0030169)	1/15	0.2721791	1	0	0	3.1821798	4.1409551	THBS1
68	protein transmembrane transporter activity (GO:0008320)	1/15	0.2721791	1	0	0	3.1821798	4.1409551	AZGP1
69	FMN binding (GO:0010181)	1/15	0.2721791	1	0	0	3.1821798	4.1409551	CREG2
70	phospholipid-translocating ATPase activity (GO:0004012)	1/15	0.2721791	1	0	0	3.1821798	4.1409551	ATP10B
71	lipid transporter activity (GO:0005319)	3/87	0.2748154	1	0	0	1.6459551	2.1260073	ATP10B;ANO7;APOB
72	solute:sodium symporter activity (GO:0015370)	2/50	0.2818931	1	0	0	1.9093079	2.4176177	SLC6A1;SLC13A5
73	transforming growth factor beta binding (GO:0050431)	1/16	0.2874383	1	0	0	2.9832936	3.7194122	THBS1
74	steroid hydroxylase activity (GO:0008395)	1/16	0.2874383	1	0	0	2.9832936	3.7194122	CYP17A1
75	calcium-release channel activity (GO:0015278)	1/16	0.2874383	1	0	0	2.9832936	3.7194122	JPH2
76	triglyceride lipase activity (GO:0004806)	1/16	0.2874383	1	0	0	2.9832936	3.7194122	LIPG
77	cytokine activity (GO:0005125)	6/213	0.2891544	1	0	0	1.3445830	1.6683513	CCL24;LEFTY1;CSF3;BMP8A;IL19;CXCL2
78	symporter activity (GO:0015293)	4/130	0.2902174	1	0	0	1.4686984	1.8169632	SLC25A18;SLC6A1;SLC13A5;SLC16A14
79	macromolecule transmembrane transporter activity (GO:0022884)	1/17	0.3023784	1	0	0	2.8078057	3.3583490	AZGP1
80	FK506 binding (GO:0005528)	1/17	0.3023784	1	0	0	2.8078057	3.3583490	FKBP5
81	macrolide binding (GO:0005527)	1/17	0.3023784	1	0	0	2.8078057	3.3583490	FKBP5
82	calcium-activated potassium channel activity (GO:0015269)	1/17	0.3023784	1	0	0	2.8078057	3.3583490	KCNN2
83	heparan sulfate proteoglycan binding (GO:0043395)	1/17	0.3023784	1	0	0	2.8078057	3.3583490	COMP
84	peptide hormone receptor binding (GO:0051428)	1/17	0.3023784	1	0	0	2.8078057	3.3583490	PTHLH
85	modified amino acid binding (GO:0072341)	2/53	0.3052188	1	0	0	1.8012338	2.1375715	JPH2;THBS1
86	transmembrane receptor protein phosphatase activity (GO:0019198)	1/18	0.3170060	1	0	0	2.6518165	3.0464985	PTPRH
87	transmembrane receptor protein tyrosine phosphatase activity (GO:0005001)	1/18	0.3170060	1	0	0	2.6518165	3.0464985	PTPRH
88	HMG box domain binding (GO:0071837)	1/18	0.3170060	1	0	0	2.6518165	3.0464985	PAX6
89	pattern binding (GO:0001871)	1/18	0.3170060	1	0	0	2.6518165	3.0464985	REG4
90	cysteine-type endopeptidase activator activity involved in apoptotic process (GO:0008656)	1/18	0.3170060	1	0	0	2.6518165	3.0464985	NKX3-1
91	acetylcholine receptor activity (GO:0015464)	1/18	0.3170060	1	0	0	2.6518165	3.0464985	CHRM1
92	lipoprotein particle receptor binding (GO:0070325)	1/18	0.3170060	1	0	0	2.6518165	3.0464985	APOB
93	polysaccharide binding (GO:0030247)	1/18	0.3170060	1	0	0	2.6518165	3.0464985	REG4
94	calcium-dependent protein binding (GO:0048306)	2/56	0.3284002	1	0	0	1.7047392	1.8982650	TNNI3;SYT8
95	histone acetyltransferase binding (GO:0035035)	1/19	0.3313276	1	0	0	2.5122472	2.7751481	PAX6
96	adrenergic receptor binding (GO:0031690)	1/19	0.3313276	1	0	0	2.5122472	2.7751481	ADRA2A
97	neurotransmitter:sodium symporter activity (GO:0005328)	1/19	0.3313276	1	0	0	2.5122472	2.7751481	SLC6A1
98	chemokine receptor binding (GO:0042379)	2/57	0.3360828	1	0	0	1.6748315	1.8262323	CCL24;CXCL2
99	carbohydrate kinase activity (GO:0019200)	1/20	0.3453496	1	0	0	2.3866348	2.5374656	HKDC1
100	fibroblast growth factor binding (GO:0017134)	1/20	0.3453496	1	0	0	2.3866348	2.5374656	THBS1
101	UDP-galactosyltransferase activity (GO:0035250)	1/20	0.3453496	1	0	0	2.3866348	2.5374656	ABO
102	alpha-actinin binding (GO:0051393)	1/20	0.3453496	1	0	0	2.3866348	2.5374656	KCNN2
103	ankyrin binding (GO:0030506)	1/21	0.3590782	1	0	0	2.2729856	2.3280260	FLNC
104	aromatase activity (GO:0070330)	1/21	0.3590782	1	0	0	2.2729856	2.3280260	CYP3A5
105	peptidase activator activity involved in apoptotic process (GO:0016505)	1/21	0.3590782	1	0	0	2.2729856	2.3280260	NKX3-1
106	glycosaminoglycan binding (GO:0005539)	5/190	0.3672648	1	0	0	1.2561236	1.2582240	COMP;REG4;LIPG;APOB;THBS1
107	secondary active transmembrane transporter activity (GO:0015291)	5/191	0.3714210	1	0	0	1.2495470	1.2375754	SLC26A2;SLC25A18;SLC6A1;SLC13A5;SLC16A14
108	phosphatidylinositol-3-phosphate binding (GO:0032266)	1/22	0.3725196	1	0	0	2.1696680	2.1424725	JPH2
109	transforming growth factor beta receptor binding (GO:0005160)	1/22	0.3725196	1	0	0	2.1696680	2.1424725	LEFTY1
110	R-SMAD binding (GO:0070412)	1/22	0.3725196	1	0	0	2.1696680	2.1424725	PAX6
111	Hsp70 protein binding (GO:0030544)	1/22	0.3725196	1	0	0	2.1696680	2.1424725	GPR37
112	heat shock protein binding (GO:0031072)	2/63	0.3815500	1	0	0	1.5153237	1.4600346	GPR37;FKBP5
113	glycolipid binding (GO:0051861)	1/23	0.3856798	1	0	0	2.0753346	1.9772706	CEACAM5
114	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription (GO:0001205)	1/23	0.3856798	1	0	0	2.0753346	1.9772706	SIX3
115	purinergic receptor activity (GO:0035586)	1/23	0.3856798	1	0	0	2.0753346	1.9772706	ADORA3
116	metallocarboxypeptidase activity (GO:0004181)	1/24	0.3985646	1	0	0	1.9888624	1.8295261	CPE
117	lipoprotein particle binding (GO:0071813)	1/24	0.3985646	1	0	0	1.9888624	1.8295261	THBS1
118	protein-lipid complex binding (GO:0071814)	1/24	0.3985646	1	0	0	1.9888624	1.8295261	THBS1
119	neurotransmitter transporter activity (GO:0005326)	1/24	0.3985646	1	0	0	1.9888624	1.8295261	SLC6A1
120	dicarboxylic acid transmembrane transporter activity (GO:0005310)	1/24	0.3985646	1	0	0	1.9888624	1.8295261	SLC13A5
121	anion transmembrane transporter activity (GO:0008509)	6/245	0.4076792	1	0	0	1.1689640	1.0488818	ANO1;SLC26A2;SLCO1B3;ANO7;SLC6A1;SLC13A5
122	Rho GTPase binding (GO:0017048)	2/67	0.4111207	1	0	0	1.4248566	1.2665099	DAAM2;CDC42EP5
123	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen (GO:0016712)	1/25	0.4111798	1	0	0	1.9093079	1.6968492	CYP3A5
124	steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor (GO:0033764)	1/25	0.4111798	1	0	0	1.9093079	1.6968492	HSD11B2
125	actinin binding (GO:0042805)	1/25	0.4111798	1	0	0	1.9093079	1.6968492	KCNN2
126	sulfur compound transmembrane transporter activity (GO:1901682)	1/26	0.4235310	1	0	0	1.8358730	1.5772510	SLC26A2
127	fibronectin binding (GO:0001968)	1/26	0.4235310	1	0	0	1.8358730	1.5772510	THBS1
128	sulfur compound binding (GO:1901681)	5/206	0.4335324	1	0	0	1.1585606	0.9683119	COMP;REG4;LIPG;APOB;THBS1
129	glutamate receptor activity (GO:0008066)	1/27	0.4356237	1	0	0	1.7678777	1.4690648	GRM8
130	Wnt-protein binding (GO:0017147)	1/27	0.4356237	1	0	0	1.7678777	1.4690648	CTHRC1
131	peptidase regulator activity (GO:0061134)	5/209	0.4458296	1	0	0	1.1419305	0.9224727	SERPINB4;AHSG;HMSD;SSPO;NKX3-1
132	growth factor activity (GO:0008083)	4/163	0.4461966	1	0	0	1.1713545	0.9452780	CSF3;LEFTY1;BMP8A;TFF1
133	chloride channel activity (GO:0005254)	2/72	0.4470730	1	0	0	1.3259082	1.0674003	ANO1;ANO7
134	phosphatidylinositol phospholipase C activity (GO:0004435)	1/28	0.4474633	1	0	0	1.7047392	1.3708842	CHRM1
135	steroid dehydrogenase activity (GO:0016229)	1/28	0.4474633	1	0	0	1.7047392	1.3708842	HSD11B2
136	estrogen receptor binding (GO:0030331)	1/28	0.4474633	1	0	0	1.7047392	1.3708842	NKX3-1
137	inorganic anion transmembrane transporter activity (GO:0015103)	3/119	0.4561068	1	0	0	1.2033453	0.9446602	ANO1;SLC26A2;ANO7
138	kinesin binding (GO:0019894)	1/29	0.4590552	1	0	0	1.6459551	1.2815157	NEK6
139	phospholipase C activity (GO:0004629)	1/30	0.4704044	1	0	0	1.5910899	1.1999403	CHRM1
140	monocarboxylic acid transmembrane transporter activity (GO:0008028)	1/30	0.4704044	1	0	0	1.5910899	1.1999403	SLC6A1
141	phosphatidylinositol-3,4,5-trisphosphate binding (GO:0005547)	1/30	0.4704044	1	0	0	1.5910899	1.1999403	JPH2
142	laminin binding (GO:0043236)	1/30	0.4704044	1	0	0	1.5910899	1.1999403	THBS1
143	growth factor binding (GO:0019838)	3/123	0.4777203	1	0	0	1.1642121	0.8600382	NTRK2;PXDN;THBS1
144	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor (GO:0016620)	1/31	0.4815161	1	0	0	1.5397644	1.1252839	ALDH1L2
145	ephrin receptor binding (GO:0046875)	1/31	0.4815161	1	0	0	1.5397644	1.1252839	NTRK2
146	calcium channel regulator activity (GO:0005246)	1/31	0.4815161	1	0	0	1.5397644	1.1252839	TNNI3
147	iron ion binding (GO:0005506)	4/172	0.4874009	1	0	0	1.1100627	0.7977670	LCN2;ALOX15B;CYP3A5;CYP17A1
148	cytokine binding (GO:0019955)	2/78	0.4885395	1	0	0	1.2239153	0.8767333	PXDN;THBS1
149	peptidase inhibitor activity (GO:0030414)	4/173	0.4919047	1	0	0	1.1036462	0.7830041	SERPINB4;AHSG;HMSD;SSPO
150	anion channel activity (GO:0005253)	2/80	0.5019244	1	0	0	1.1933174	0.8225606	ANO1;ANO7
151	organic anion transmembrane transporter activity (GO:0008514)	3/130	0.5145426	1	0	0	1.1015238	0.7319371	SLCO1B3;SLC6A1;SLC13A5
152	solute:cation symporter activity (GO:0015294)	2/82	0.5150817	1	0	0	1.1642121	0.7723730	SLC6A1;SLC13A5
153	cytokine receptor binding (GO:0005126)	5/228	0.5217758	1	0	0	1.0467697	0.6809418	CCL24;LEFTY1;CSF3;PXDN;CXCL2
154	peptide antigen binding (GO:0042605)	1/35	0.5236849	1	0	0	1.3637913	0.8821891	AZGP1
155	acetylgalactosaminyltransferase activity (GO:0008376)	1/35	0.5236849	1	0	0	1.3637913	0.8821891	ABO
156	G-protein coupled receptor binding (GO:0001664)	5/229	0.5256558	1	0	0	1.0421986	0.6702470	CCL24;WNT16;CXCL2;ADRA2A;CTHRC1
157	ATP-dependent DNA helicase activity (GO:0004003)	1/36	0.5336812	1	0	0	1.3259082	0.8326130	RTEL1-TNFRSF6B
158	protein phosphatase inhibitor activity (GO:0004864)	1/36	0.5336812	1	0	0	1.3259082	0.8326130	PHACTR3
159	calcium-dependent phospholipid binding (GO:0005544)	1/36	0.5336812	1	0	0	1.3259082	0.8326130	DOC2B
160	chloride transmembrane transporter activity (GO:0015108)	2/86	0.5406975	1	0	0	1.1100627	0.6825724	ANO1;ANO7
161	peptidase activator activity (GO:0016504)	1/37	0.5434681	1	0	0	1.2900729	0.7866661	NKX3-1
162	dioxygenase activity (GO:0051213)	2/87	0.5469535	1	0	0	1.0973034	0.6621035	PTGS2;ALOX15B
163	RNA polymerase II regulatory region sequence-specific DNA binding (GO:0000977)	6/284	0.5489403	1	0	0	1.0084373	0.6048260	MUC1;CUX2;SIX3;PAX6;BHLHA15;FEZF1
164	phosphatase inhibitor activity (GO:0019212)	1/38	0.5530502	1	0	0	1.2561236	0.7440102	PHACTR3
165	metalloexopeptidase activity (GO:0008235)	1/39	0.5624316	1	0	0	1.2239153	0.7043459	CPE
166	cysteine-type endopeptidase regulator activity involved in apoptotic process (GO:0043028)	1/39	0.5624316	1	0	0	1.2239153	0.7043459	NKX3-1
167	RNA polymerase II regulatory region DNA binding (GO:0001012)	6/288	0.5626366	1	0	0	0.9944312	0.5719185	MUC1;CUX2;SIX3;PAX6;BHLHA15;FEZF1
168	phospholipase activity (GO:0004620)	2/90	0.5653620	1	0	0	1.0607266	0.6049208	CHRM1;LIPG
169	transcription regulatory region sequence-specific DNA binding (GO:0000976)	7/340	0.5715885	1	0	0	0.9827320	0.5496773	MUC1;CUX2;SIX3;PAX6;BHLHA15;FEZF1;NKX3-1
170	protein self-association (GO:0043621)	1/40	0.5716165	1	0	0	1.1933174	0.6674069	NKX3-1
171	carboxypeptidase activity (GO:0004180)	1/40	0.5716165	1	0	0	1.1933174	0.6674069	CPE
172	peptidyl-prolyl cis-trans isomerase activity (GO:0003755)	1/41	0.5806091	1	0	0	1.1642121	0.6329560	FKBP5
173	phosphatidylinositol-4,5-bisphosphate binding (GO:0005546)	1/41	0.5806091	1	0	0	1.1642121	0.6329560	JPH2
174	drug binding (GO:0008144)	2/93	0.5832269	1	0	0	1.0265096	0.5534724	CHRM1;FKBP5
175	oxidoreductase activity, acting on the aldehyde or oxo group of donors (GO:0016903)	1/42	0.5894134	1	0	0	1.1364928	0.6007814	ALDH1L2
176	receptor regulator activity (GO:0030545)	1/42	0.5894134	1	0	0	1.1364928	0.6007814	PXDN
177	RNA polymerase II core promoter sequence-specific DNA binding (GO:0000979)	1/43	0.5980332	1	0	0	1.1100627	0.5706932	PAX6
178	cis-trans isomerase activity (GO:0016859)	1/43	0.5980332	1	0	0	1.1100627	0.5706932	FKBP5
179	acetylglucosaminyltransferase activity (GO:0008375)	1/44	0.6064726	1	0	0	1.0848340	0.5425209	B3GNT6
180	syntaxin binding (GO:0019905)	1/44	0.6064726	1	0	0	1.0848340	0.5425209	STXBP5L
181	voltage-gated calcium channel activity (GO:0005245)	1/44	0.6064726	1	0	0	1.0848340	0.5425209	CACNA1E
182	actin filament binding (GO:0051015)	2/98	0.6117869	1	0	0	0.9741367	0.4786628	SHROOM1;FLNC
183	serine-type endopeptidase inhibitor activity (GO:0004867)	2/98	0.6117869	1	0	0	0.9741367	0.4786628	SERPINB4;HMSD
184	monooxygenase activity (GO:0004497)	2/99	0.6173166	1	0	0	0.9642969	0.4651511	CYP3A5;CYP17A1
185	active transmembrane transporter activity (GO:0022804)	6/307	0.6248122	1	0	0	0.9328866	0.4387404	SLC26A2;SLC25A18;ATP10B;SLC6A1;SLC13A5;SLC16A14
186	carboxylic acid transmembrane transporter activity (GO:0046943)	2/101	0.6281942	1	0	0	0.9452019	0.4394299	SLC6A1;SLC13A5
187	channel regulator activity (GO:0016247)	2/102	0.6335424	1	0	0	0.9359352	0.4271873	ANKRD36C;TNNI3
188	organic acid transmembrane transporter activity (GO:0005342)	2/104	0.6440582	1	0	0	0.9179365	0.4038609	SLC6A1;SLC13A5
189	protein kinase activator activity (GO:0030295)	1/49	0.6460903	1	0	0	0.9741367	0.4255184	NKX3-1
190	cysteine-type endopeptidase inhibitor activity (GO:0004869)	1/49	0.6460903	1	0	0	0.9741367	0.4255184	AHSG
191	lipase activity (GO:0016298)	2/105	0.6492262	1	0	0	0.9091942	0.3927483	CHRM1;LIPG
192	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity (GO:0004879)	1/50	0.6535229	1	0	0	0.9546539	0.4060885	NKX3-1
193	NAD binding (GO:0051287)	1/50	0.6535229	1	0	0	0.9546539	0.4060885	HSD11B2
194	direct ligand regulated sequence-specific DNA binding transcription factor activity (GO:0098531)	1/50	0.6535229	1	0	0	0.9546539	0.4060885	NKX3-1
195	amino acid binding (GO:0016597)	2/107	0.6593834	1	0	0	0.8921999	0.3715567	JPH2;THBS1
196	DNA helicase activity (GO:0003678)	1/51	0.6607998	1	0	0	0.9359352	0.3877621	RTEL1-TNFRSF6B
197	extracellular matrix binding (GO:0050840)	1/51	0.6607998	1	0	0	0.9359352	0.3877621	THBS1
198	carbon-carbon lyase activity (GO:0016830)	1/51	0.6607998	1	0	0	0.9359352	0.3877621	CYP17A1
199	calcium channel activity (GO:0005262)	2/108	0.6643731	1	0	0	0.8839388	0.3614526	JPH2;CACNA1E
200	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen (GO:0016705)	3/163	0.6670891	1	0	0	0.8785159	0.3556511	PTGS2;CYP3A5;CYP17A1
201	sulfotransferase activity (GO:0008146)	1/52	0.6679242	1	0	0	0.9179365	0.3704614	SULT1C2
202	double-stranded DNA binding (GO:0003690)	2/109	0.6693038	1	0	0	0.8758293	0.3516605	ZBTB16;PAX6
203	copper ion binding (GO:0005507)	1/53	0.6748993	1	0	0	0.9006169	0.3541152	F5
204	core promoter binding (GO:0001047)	2/111	0.6789896	1	0	0	0.8600486	0.3329674	PAX6;NKX3-1
205	endopeptidase inhibitor activity (GO:0004866)	3/166	0.6790707	1	0	0	0.8626391	0.3338672	SERPINB4;AHSG;HMSD
206	RNA polymerase II core promoter proximal region sequence-specific DNA binding (GO:0000978)	3/167	0.6829931	1	0	0	0.8574736	0.3269295	MUC1;PAX6;FEZF1
207	kinase activator activity (GO:0019209)	1/55	0.6884140	1	0	0	0.8678672	0.3240311	NKX3-1
208	RNA polymerase II distal enhancer sequence-specific DNA binding (GO:0000980)	1/56	0.6949597	1	0	0	0.8523696	0.3101785	SIX3
209	phosphatidylinositol bisphosphate binding (GO:1902936)	1/56	0.6949597	1	0	0	0.8523696	0.3101785	JPH2
210	p53 binding (GO:0002039)	1/56	0.6949597	1	0	0	0.8523696	0.3101785	MUC1
211	endopeptidase regulator activity (GO:0061135)	3/171	0.6983256	1	0	0	0.8374157	0.3006907	SERPINB4;AHSG;HMSD
212	steroid hormone receptor activity (GO:0003707)	1/57	0.7013682	1	0	0	0.8374157	0.2970500	NKX3-1
213	kinase inhibitor activity (GO:0019210)	1/57	0.7013682	1	0	0	0.8374157	0.2970500	AHSG
214	SNARE binding (GO:0000149)	1/59	0.7137851	1	0	0	0.8090288	0.2727830	STXBP5L
215	core promoter proximal region sequence-specific DNA binding (GO:0000987)	3/176	0.7166933	1	0	0	0.8136255	0.2710246	MUC1;PAX6;FEZF1
216	core promoter proximal region DNA binding (GO:0001159)	3/178	0.7237942	1	0	0	0.8044837	0.2600478	MUC1;PAX6;FEZF1
217	transferase activity, transferring sulfur-containing groups (GO:0016782)	1/64	0.7426200	1	0	0	0.7458234	0.2219352	SULT1C2
218	phospholipid binding (GO:0005543)	5/296	0.7459211	1	0	0	0.8062956	0.2363538	JPH2;CEACAM5;DOC2B;APOB;THBS1
219	transmembrane receptor protein tyrosine kinase activity (GO:0004714)	1/65	0.7480294	1	0	0	0.7343492	0.2131911	NTRK2
220	protein phosphatase regulator activity (GO:0019888)	1/65	0.7480294	1	0	0	0.7343492	0.2131911	PHACTR3
221	cation-transporting ATPase activity (GO:0019829)	1/65	0.7480294	1	0	0	0.7343492	0.2131911	ATP10B
222	calcium ion transmembrane transporter activity (GO:0015085)	2/127	0.7483486	1	0	0	0.7516960	0.2179064	JPH2;CACNA1E
223	sodium ion transmembrane transporter activity (GO:0015081)	2/128	0.7522246	1	0	0	0.7458234	0.2123511	SLC6A1;SLC13A5
224	amino acid transmembrane transporter activity (GO:0015171)	1/66	0.7533254	1	0	0	0.7232227	0.2048586	SLC6A1
225	ATPase activity, coupled to transmembrane movement of ions (GO:0042625)	1/67	0.7585103	1	0	0	0.7124283	0.1969144	ATP10B
226	steroid hormone receptor binding (GO:0035258)	1/67	0.7585103	1	0	0	0.7124283	0.1969144	NKX3-1
227	magnesium ion binding (GO:0000287)	3/190	0.7635108	1	0	0	0.7536742	0.2033624	NEK6;ATP10B;IRAK3
228	SMAD binding (GO:0046332)	1/68	0.7635865	1	0	0	0.7019514	0.1893366	PAX6
229	UDP-glycosyltransferase activity (GO:0008194)	2/132	0.7672185	1	0	0	0.7232227	0.1916422	B3GNT6;ABO
230	enhancer sequence-specific DNA binding (GO:0001158)	1/70	0.7734217	1	0	0	0.6818957	0.1752000	SIX3
231	transferase activity, transferring hexosyl groups (GO:0016758)	3/194	0.7756778	1	0	0	0.7381345	0.1874994	FUT6;B3GNT6;ABO
232	core promoter sequence-specific DNA binding (GO:0001046)	1/71	0.7781852	1	0	0	0.6722915	0.1686045	PAX6
233	neurotransmitter receptor activity (GO:0030594)	1/74	0.7918844	1	0	0	0.6450364	0.1505127	CHRM1
234	phosphatase regulator activity (GO:0019208)	1/75	0.7962606	1	0	0	0.6364360	0.1449984	PHACTR3
235	histone deacetylase binding (GO:0042826)	1/75	0.7962606	1	0	0	0.6364360	0.1449984	NKX3-1
236	kinase regulator activity (GO:0019207)	2/141	0.7980965	1	0	0	0.6770595	0.1526943	AHSG;NKX3-1
237	RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription (GO:0001228)	3/202	0.7984723	1	0	0	0.7089014	0.1595418	SIX3;PAX6;BHLHA15
238	protease binding (GO:0002020)	1/77	0.8047394	1	0	0	0.6199052	0.1346662	COMP
239	gated channel activity (GO:0022836)	5/323	0.8098460	1	0	0	0.7388962	0.1558415	ANO1;JPH2;KCNN2;ANO7;CACNA1E
240	DNA-dependent ATPase activity (GO:0008094)	1/80	0.8168022	1	0	0	0.5966587	0.1207388	RTEL1-TNFRSF6B
241	vitamin binding (GO:0019842)	1/80	0.8168022	1	0	0	0.5966587	0.1207388	TCN1
242	protein transporter activity (GO:0008565)	1/81	0.8206556	1	0	0	0.5892926	0.1164747	AZGP1
243	actin binding (GO:0003779)	6/386	0.8221131	1	0	0	0.7419590	0.1453330	SNTG2;DAAM2;PHACTR3;TNNI3;FLNC;SHROOM1
244	transmembrane receptor protein kinase activity (GO:0019199)	1/82	0.8244281	1	0	0	0.5821061	0.1123845	NTRK2
245	steroid binding (GO:0005496)	1/82	0.8244281	1	0	0	0.5821061	0.1123845	HSD11B2
246	helicase activity (GO:0004386)	2/150	0.8252959	1	0	0	0.6364360	0.1222042	RTEL1-TNFRSF6B;DQX1
247	enhancer binding (GO:0035326)	1/83	0.8281214	1	0	0	0.5750927	0.1084599	SIX3
248	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity (GO:0003705)	1/84	0.8317373	1	0	0	0.5682464	0.1046930	SIX3
249	cytokine receptor activity (GO:0004896)	1/85	0.8352772	1	0	0	0.5615611	0.1010763	IL1R2
250	enzyme inhibitor activity (GO:0004857)	5/336	0.8357199	1	0	0	0.7103080	0.1274731	SERPINB4;AHSG;HMSD;PHACTR3;SSPO
251	divalent inorganic cation transmembrane transporter activity (GO:0072509)	2/154	0.8362938	1	0	0	0.6199052	0.1108237	JPH2;CACNA1E
252	ribonuclease activity (GO:0004540)	1/86	0.8387428	1	0	0	0.5550314	0.0976029	AZGP1
253	purine NTP-dependent helicase activity (GO:0070035)	1/89	0.8487093	1	0	0	0.5363224	0.0879775	RTEL1-TNFRSF6B
254	ATP-dependent helicase activity (GO:0008026)	1/89	0.8487093	1	0	0	0.5363224	0.0879775	RTEL1-TNFRSF6B
255	cation channel activity (GO:0005261)	4/285	0.8509126	1	0	0	0.6699326	0.1081579	ANO1;JPH2;KCNN2;CACNA1E
256	hormone receptor binding (GO:0051427)	2/160	0.8516207	1	0	0	0.5966587	0.0958317	PTHLH;NKX3-1
257	phosphoric diester hydrolase activity (GO:0008081)	1/90	0.8518930	1	0	0	0.5303633	0.0850142	CHRM1
258	phosphatidylinositol phosphate binding (GO:1901981)	1/91	0.8550098	1	0	0	0.5245351	0.0821644	JPH2
259	protein C-terminus binding (GO:0008022)	2/162	0.8564324	1	0	0	0.5892926	0.0913285	ZBTB16;FIGN
260	calcium ion binding (GO:0005509)	11/698	0.8691675	1	0	0	0.7522345	0.1054778	COMP;FBN2;CGREF1;TPO;REG4;PCDH15;CDH15;ALOX15B;CACNA1E;NID2;THBS1
261	PDZ domain binding (GO:0030165)	1/96	0.8696394	1	0	0	0.4972156	0.0694494	SNTG2
262	cell adhesion molecule binding (GO:0050839)	2/168	0.8700252	1	0	0	0.5682464	0.0791187	CPE;THBS1
263	calmodulin binding (GO:0005516)	2/170	0.8742870	1	0	0	0.5615611	0.0754438	PNCK;KCNN2
264	peptide binding (GO:0042277)	2/172	0.8784200	1	0	0	0.5550314	0.0719490	AZGP1;GPR37
265	protein homodimerization activity (GO:0042803)	10/653	0.8812457	1	0	0	0.7309755	0.0924090	NTRK2;ANO1;CDSN;ZBTB16;CEACAM5;KCNN2;IRAK3;BHLHA15;PTGS2;ADRA2A
266	integrin binding (GO:0005178)	1/102	0.8852638	1	0	0	0.4679676	0.0570310	THBS1
267	protein tyrosine phosphatase activity (GO:0004725)	1/103	0.8876798	1	0	0	0.4634242	0.0552143	PTPRH
268	amide binding (GO:0033218)	2/177	0.8882102	1	0	0	0.5393525	0.0639385	AZGP1;GPR37
269	ATPase activity, coupled to transmembrane movement of substances (GO:0042626)	1/104	0.8900451	1	0	0	0.4589682	0.0534621	ATP10B
270	phosphatidylinositol binding (GO:0035091)	2/178	0.8900786	1	0	0	0.5363224	0.0624523	JPH2;CEACAM5
271	ATPase activity, coupled to movement of substances (GO:0043492)	1/105	0.8923606	1	0	0	0.4545971	0.0517718	ATP10B
272	metalloendopeptidase activity (GO:0004222)	1/106	0.8946275	1	0	0	0.4503085	0.0501409	ADAMDEC1
273	small conjugating protein ligase binding (GO:0044389)	2/182	0.8972662	1	0	0	0.5245351	0.0568610	GPR37;PAX6
274	ubiquitin protein ligase binding (GO:0031625)	2/182	0.8972662	1	0	0	0.5245351	0.0568610	GPR37;PAX6
275	hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances (GO:0016820)	1/108	0.8990194	1	0	0	0.4419694	0.0470479	ATP10B
276	primary active transmembrane transporter activity (GO:0015399)	1/111	0.9052673	1	0	0	0.4300243	0.0427982	ATP10B
277	P-P-bond-hydrolysis-driven transmembrane transporter activity (GO:0015405)	1/111	0.9052673	1	0	0	0.4300243	0.0427982	ATP10B
278	exopeptidase activity (GO:0008238)	1/111	0.9052673	1	0	0	0.4300243	0.0427982	CPE
279	carboxylic ester hydrolase activity (GO:0052689)	1/111	0.9052673	1	0	0	0.4300243	0.0427982	LIPG
280	metallopeptidase activity (GO:0008237)	2/188	0.9072319	1	0	0	0.5077946	0.0494375	ADAMDEC1;CPE
281	serine-type peptidase activity (GO:0008236)	2/188	0.9072319	1	0	0	0.5077946	0.0494375	PRSS16;PLAT
282	coenzyme binding (GO:0050662)	2/188	0.9072319	1	0	0	0.5077946	0.0494375	HSD11B2;CREG2
283	serine hydrolase activity (GO:0017171)	2/191	0.9118692	1	0	0	0.4998188	0.0461126	PRSS16;PLAT
284	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor (GO:0016616)	1/115	0.9130018	1	0	0	0.4150669	0.0377783	HSD11B2
285	Ras GTPase binding (GO:0017016)	2/193	0.9148392	1	0	0	0.4946393	0.0440263	DAAM2;CDC42EP5
286	potassium channel activity (GO:0005267)	1/118	0.9183864	1	0	0	0.4045144	0.0344392	KCNN2
287	ion channel activity (GO:0005216)	5/396	0.9204088	1	0	0	0.6026856	0.0499851	ANO1;JPH2;KCNN2;ANO7;CACNA1E
288	sequence-specific DNA binding RNA polymerase II transcription factor activity (GO:0000981)	5/397	0.9214137	1	0	0	0.6011675	0.0492032	SIX3;PAX6;BHLHA15;SPDEF;NKX3-1
289	G-protein coupled peptide receptor activity (GO:0008528)	1/121	0.9234384	1	0	0	0.3944851	0.0314212	GPR37
290	growth factor receptor binding (GO:0070851)	1/121	0.9234384	1	0	0	0.3944851	0.0314212	CSF3
291	protein kinase regulator activity (GO:0019887)	1/121	0.9234384	1	0	0	0.3944851	0.0314212	NKX3-1
292	metal ion transmembrane transporter activity (GO:0046873)	5/400	0.9243615	1	0	0	0.5966587	0.0469284	JPH2;KCNN2;SLC6A1;SLC13A5;CACNA1E
293	carboxylic acid binding (GO:0031406)	2/200	0.9245113	1	0	0	0.4773270	0.0374654	JPH2;THBS1
294	organic acid binding (GO:0043177)	2/201	0.9258056	1	0	0	0.4749522	0.0366145	JPH2;THBS1
295	peptide receptor activity (GO:0001653)	1/123	0.9266318	1	0	0	0.3880707	0.0295706	GPR37
296	substrate-specific channel activity (GO:0022838)	5/406	0.9299649	1	0	0	0.5878411	0.0426822	ANO1;JPH2;KCNN2;ANO7;CACNA1E
297	transferase activity, transferring glycosyl groups (GO:0016757)	3/280	0.9350530	1	0	0	0.5114218	0.0343430	FUT6;B3GNT6;ABO
298	small GTPase binding (GO:0031267)	2/209	0.9354316	1	0	0	0.4567722	0.0304883	DAAM2;CDC42EP5
299	oxidoreductase activity, acting on CH-OH group of donors (GO:0016614)	1/131	0.9381306	1	0	0	0.3643717	0.0232710	HSD11B2
300	potassium ion transmembrane transporter activity (GO:0015079)	1/138	0.9467066	1	0	0	0.3458891	0.0189430	KCNN2
301	channel activity (GO:0015267)	5/427	0.9467779	1	0	0	0.5589309	0.0305683	ANO1;JPH2;KCNN2;ANO7;CACNA1E
302	passive transmembrane transporter activity (GO:0022803)	5/427	0.9467779	1	0	0	0.5589309	0.0305683	ANO1;JPH2;KCNN2;ANO7;CACNA1E
303	GTPase binding (GO:0051020)	2/221	0.9476823	1	0	0	0.4319701	0.0232123	DAAM2;CDC42EP5
304	nuclear hormone receptor binding (GO:0035257)	1/139	0.9478308	1	0	0	0.3434007	0.0183992	NKX3-1
305	protein tyrosine kinase activity (GO:0004713)	1/142	0.9510635	1	0	0	0.3361458	0.0168659	NTRK2
306	ligand-gated ion channel activity (GO:0015276)	1/145	0.9540962	1	0	0	0.3291910	0.0154689	JPH2
307	ligand-gated channel activity (GO:0022834)	1/145	0.9540962	1	0	0	0.3291910	0.0154689	JPH2
308	voltage-gated cation channel activity (GO:0022843)	1/149	0.9578502	1	0	0	0.3203537	0.0137957	CACNA1E
309	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription (GO:0001077)	1/151	0.9596107	1	0	0	0.3161106	0.0130325	PAX6
310	protein serine/threonine kinase activity (GO:0004674)	5/449	0.9604014	1	0	0	0.5315445	0.0214765	PNCK;PDPK2;NEK6;IRAK3;MYLK3
311	structure-specific DNA binding (GO:0043566)	2/241	0.9633299	1	0	0	0.3961220	0.0147989	ZBTB16;PAX6
312	isomerase activity (GO:0016853)	1/159	0.9659489	1	0	0	0.3002056	0.0104004	FKBP5
313	serine-type endopeptidase activity (GO:0004252)	1/167	0.9712944	1	0	0	0.2858245	0.0083248	PLAT
314	microtubule binding (GO:0008017)	1/171	0.9736444	1	0	0	0.2791386	0.0074556	JAKMIP3
315	phosphoprotein phosphatase activity (GO:0004721)	1/172	0.9742013	1	0	0	0.2775157	0.0072535	PTPRH
316	monovalent inorganic cation transmembrane transporter activity (GO:0015077)	3/343	0.9761482	1	0	0	0.4174871	0.0100785	KCNN2;SLC6A1;SLC13A5
317	GTPase activator activity (GO:0005096)	2/265	0.9762254	1	0	0	0.3602468	0.0086682	ARHGAP40;ELMOD1
318	cofactor binding (GO:0048037)	2/266	0.9766543	1	0	0	0.3588925	0.0084780	HSD11B2;CREG2
319	kinase binding (GO:0019900)	5/487	0.9766571	1	0	0	0.4900688	0.0115752	NEK6;PAX6;TNNI3;ADRA2A;JAKMIP3
320	lyase activity (GO:0016829)	1/177	0.9768143	1	0	0	0.2696763	0.0063262	CYP17A1
321	ATPase activity, coupled (GO:0042623)	2/272	0.9790748	1	0	0	0.3509757	0.0074222	RTEL1-TNFRSF6B;ATP10B
322	inorganic cation transmembrane transporter activity (GO:0022890)	5/497	0.9797583	1	0	0	0.4802082	0.0098200	JPH2;KCNN2;SLC6A1;SLC13A5;CACNA1E
323	voltage-gated channel activity (GO:0022832)	1/189	0.9820583	1	0	0	0.2525540	0.0045724	CACNA1E
324	voltage-gated ion channel activity (GO:0005244)	1/189	0.9820583	1	0	0	0.2525540	0.0045724	CACNA1E
325	protein kinase binding (GO:0019901)	4/437	0.9827203	1	0	0	0.4369126	0.0076157	NEK6;PAX6;TNNI3;ADRA2A
326	nuclease activity (GO:0004518)	1/195	0.9842180	1	0	0	0.2447831	0.0038940	AZGP1
327	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity (GO:0000982)	1/204	0.9869809	1	0	0	0.2339838	0.0030663	PAX6
328	transcription corepressor activity (GO:0003714)	1/208	0.9880485	1	0	0	0.2294841	0.0027592	TFCP2L1
329	methyltransferase activity (GO:0008168)	1/210	0.9885491	1	0	0	0.2272986	0.0026178	ALDH1L2
330	transcription factor binding (GO:0008134)	4/464	0.9886529	1	0	0	0.4114888	0.0046959	SIX3;PAX6;FOXA3;NKX3-1
331	antigen binding (GO:0003823)	1/212	0.9890288	1	0	0	0.2251542	0.0024839	AZGP1
332	GTPase regulator activity (GO:0030695)	2/310	0.9896280	1	0	0	0.3079529	0.0032108	ARHGAP40;ELMOD1
333	transferase activity, transferring one-carbon groups (GO:0016741)	1/218	0.9903507	1	0	0	0.2189573	0.0021230	ALDH1L2
334	GTPase activity (GO:0003924)	1/224	0.9915137	1	0	0	0.2130924	0.0018161	RAB43
335	protein heterodimerization activity (GO:0046982)	3/408	0.9919877	1	0	0	0.3509757	0.0028234	ANO1;IRAK3;ADRA2A
336	nucleoside-triphosphatase regulator activity (GO:0060589)	2/330	0.9928693	1	0	0	0.2892891	0.0020702	ARHGAP40;ELMOD1
337	tubulin binding (GO:0015631)	1/241	0.9941033	1	0	0	0.1980610	0.0011714	JAKMIP3
338	enzyme activator activity (GO:0008047)	3/446	0.9958542	1	0	0	0.3210720	0.0013339	ARHGAP40;ELMOD1;NKX3-1
339	phosphoric ester hydrolase activity (GO:0042578)	2/360	0.9959591	1	0	0	0.2651816	0.0010737	CHRM1;PTPRH
340	phosphatase activity (GO:0016791)	1/266	0.9965494	1	0	0	0.1794462	0.0006203	PTPRH
341	carbohydrate binding (GO:0030246)	1/278	0.9973324	1	0	0	0.1717003	0.0004586	REG4
342	ubiquitin-protein transferase activity (GO:0004842)	1/279	0.9973890	1	0	0	0.1710849	0.0004473	PAX6
343	ATPase activity (GO:0016887)	2/395	0.9979329	1	0	0	0.2416845	0.0005001	RTEL1-TNFRSF6B;ATP10B
344	transcription coactivator activity (GO:0003713)	1/291	0.9979816	1	0	0	0.1640299	0.0003314	SIX3
345	endopeptidase activity (GO:0004175)	2/411	0.9984821	1	0	0	0.2322759	0.0003528	ADAMDEC1;PLAT
346	GTP binding (GO:0005525)	1/385	0.9997308	1	0	0	0.1239810	0.0000334	RAB43
347	guanyl ribonucleotide binding (GO:0032561)	1/405	0.9998241	1	0	0	0.1178585	0.0000207	RAB43
348	guanyl nucleotide binding (GO:0019001)	1/406	0.9998278	1	0	0	0.1175682	0.0000202	RAB43
349	chromatin binding (GO:0003682)	1/420	0.9998719	1	0	0	0.1136493	0.0000146	PAX6
350	ATP binding (GO:0005524)	13/1494	0.9999555	1	0	0	0.4153448	0.0000185	NTRK2;RTEL1-TNFRSF6B;ENTPD2;PNCK;PDPK2;DQX1;NEK6;ATP10B;ENTPD8;FIGN;IRAK3;MYLK3;HKDC1
351	zinc ion binding (GO:0008270)	2/1256	0.9999954	1	0	0	0.0760075	0.0000003	ADAMDEC1;CPE

EnrichR, downregulated genes

## Uploading data to Enrichr... Done.
##   Querying GO_Molecular_Function_2015... Done.
##   Querying GO_Cellular_Component_2015... Done.
##   Querying GO_Biological_Process_2015... Done.
## Parsing results... Done.

GO_Biological_Process_2015

go_biological %>%
  knitr::kable(
    format = "html", align = rep("c", ncol(go_biological) + 1),
    row.names = TRUE
  ) %>%
  kableExtra::kable_styling() %>%
  kableExtra::scroll_box(height = "300px")

	Term	Overlap	P.value	Adjusted.P.value	Old.P.value	Old.Adjusted.P.value	Odds.Ratio	Combined.Score	Genes
1	synaptic transmission (GO:0007268)	14/434	0.0001261	0.6546647	0	0	3.2258065	28.9629235	GABBR2;KCNJ6;GRID1;SLC6A13;KCNA3;KCNA4;GRIK1;SLC5A7;NPBWR1;SNCG;ANXA9;GABRD;KCNJ1;KCNK3
2	macrophage chemotaxis (GO:0048246)	3/14	0.0003306	0.8581617	0	0	21.4285714	171.7433537	CX3CR1;CCL5;SFTPD
3	negative regulation of viral genome replication (GO:0045071)	4/40	0.0006691	1.0000000	0	0	10.0000000	73.0963454	APOBEC3H;CCL5;IFIT1;OASL
4	sprouting angiogenesis (GO:0002040)	3/24	0.0017077	1.0000000	0	0	12.5000000	79.6578471	RAMP2;FLT4;GPR124
5	cellular potassium ion transport (GO:0071804)	6/129	0.0019065	1.0000000	0	0	4.6511628	29.1279537	KCNJ6;CNGA1;KCNA3;KCNA4;KCNJ1;KCNK3
6	potassium ion transmembrane transport (GO:0071805)	6/129	0.0019065	1.0000000	0	0	4.6511628	29.1279537	KCNJ6;CNGA1;KCNA3;KCNA4;KCNJ1;KCNK3
7	positive regulation of vasodilation (GO:0045909)	3/26	0.0021617	1.0000000	0	0	11.5384615	70.8100816	NPPC;GJA1;ALOX12
8	regulation of viral genome replication (GO:0045069)	4/57	0.0025341	1.0000000	0	0	7.0175439	41.9501817	APOBEC3H;CCL5;IFIT1;OASL
9	cytidine deamination (GO:0009972)	2/9	0.0034202	1.0000000	0	0	22.2222222	126.1788209	APOBEC2;APOBEC3H
10	cytidine metabolic process (GO:0046087)	2/9	0.0034202	1.0000000	0	0	22.2222222	126.1788209	APOBEC2;APOBEC3H
11	cytidine catabolic process (GO:0006216)	2/9	0.0034202	1.0000000	0	0	22.2222222	126.1788209	APOBEC2;APOBEC3H
12	potassium ion transport (GO:0006813)	6/151	0.0041682	1.0000000	0	0	3.9735099	21.7758854	KCNJ6;CNGA1;KCNA3;KCNA4;KCNJ1;KCNK3
13	pyrimidine ribonucleoside catabolic process (GO:0046133)	2/10	0.0042472	1.0000000	0	0	20.0000000	109.2297554	APOBEC2;APOBEC3H
14	ethanol oxidation (GO:0006069)	2/11	0.0051570	1.0000000	0	0	18.1818182	95.7708415	ADH1C;ADH1B
15	positive regulation of blood circulation (GO:1903524)	4/72	0.0058778	1.0000000	0	0	5.5555556	28.5365281	NPPC;GJA1;OR51E2;ALOX12
16	male sex determination (GO:0030238)	2/12	0.0061479	1.0000000	0	0	16.6666667	84.8608119	FGF9;DMRT1
17	negative regulation of viral process (GO:0048525)	4/75	0.0067856	1.0000000	0	0	5.3333333	26.6290906	APOBEC3H;CCL5;IFIT1;OASL
18	regulation of vasodilation (GO:0042312)	3/39	0.0069091	1.0000000	0	0	7.6923077	38.2686129	NPPC;GJA1;ALOX12
19	myeloid leukocyte migration (GO:0097529)	4/76	0.0071076	1.0000000	0	0	5.2631579	26.0346606	CX3CR1;PLA2G1B;CCL5;SFTPD
20	ethanol metabolic process (GO:0006067)	2/14	0.0083660	1.0000000	0	0	14.2857143	68.3368024	ADH1C;ADH1B
21	regulation of cellular response to growth factor stimulus (GO:0090287)	6/176	0.0086499	1.0000000	0	0	3.4090909	16.1939003	FGF9;HHIP;PEG10;FGF18;FBN1;GPR124
22	positive regulation of protein dephosphorylation (GO:0035307)	2/16	0.0108884	1.0000000	0	0	12.5000000	56.5006873	DLC1;DUSP26
23	adult heart development (GO:0007512)	2/16	0.0108884	1.0000000	0	0	12.5000000	56.5006873	GJA1;SCUBE1
24	positive regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030949)	2/16	0.0108884	1.0000000	0	0	12.5000000	56.5006873	FGF9;FGF18
25	negative regulation of multi-organism process (GO:0043901)	5/133	0.0109104	1.0000000	0	0	3.7593985	16.9851219	NPPC;APOBEC3H;CCL5;IFIT1;OASL
26	positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)	2/18	0.0137022	1.0000000	0	0	11.1111111	47.6688727	KLRK1;CRTAM
27	regulation of antigen processing and presentation (GO:0002577)	2/18	0.0137022	1.0000000	0	0	11.1111111	47.6688727	HLA-DOA;HLA-DQB2
28	positive regulation of viral genome replication (GO:0045070)	2/18	0.0137022	1.0000000	0	0	11.1111111	47.6688727	CCL5;IFIT1
29	negative regulation of meiotic cell cycle (GO:0051447)	2/18	0.0137022	1.0000000	0	0	11.1111111	47.6688727	NPPC;DMRT1
30	positive regulation of natural killer cell mediated immunity (GO:0002717)	2/19	0.0152144	1.0000000	0	0	10.5263158	44.0579974	KLRK1;CRTAM
31	monovalent inorganic cation transport (GO:0015672)	9/384	0.0154664	1.0000000	0	0	2.3437500	9.7712881	SLC5A7;KCNJ6;KCNA3;SLC4A10;CNGA1;KCNA4;KCNJ1;KCNK3;SLC38A4
32	regulation of T cell activation (GO:0050863)	7/259	0.0156398	1.0000000	0	0	2.7027027	11.2376588	KLRK1;CCL5;SFTPD;TRAC;SCGB1A1;HLA-DOA;HLA-DQB2
33	regulation of protein dephosphorylation (GO:0035304)	2/20	0.0167949	1.0000000	0	0	10.0000000	40.8668071	DLC1;DUSP26
34	regulation of homotypic cell-cell adhesion (GO:0034110)	2/20	0.0167949	1.0000000	0	0	10.0000000	40.8668071	CCL5;ALOX12
35	positive regulation of endothelial cell migration (GO:0010595)	3/55	0.0176581	1.0000000	0	0	5.4545455	22.0176155	FLT4;ALOX12;GPR124
36	leukocyte chemotaxis (GO:0030595)	4/100	0.0180733	1.0000000	0	0	4.0000000	16.0532734	CX3CR1;PLA2G1B;CCL5;SFTPD
37	sex determination (GO:0007530)	2/22	0.0201544	1.0000000	0	0	9.0909091	35.4939443	DMRT1;FGF9
38	pyrimidine nucleoside catabolic process (GO:0046135)	2/22	0.0201544	1.0000000	0	0	9.0909091	35.4939443	APOBEC2;APOBEC3H
39	regulation of tissue remodeling (GO:0034103)	3/58	0.0203229	1.0000000	0	0	5.1724138	20.1517517	MC4R;GJA1;FLT4
40	xenobiotic metabolic process (GO:0006805)	5/156	0.0204245	1.0000000	0	0	3.2051282	12.4712148	CYP2W1;ADH1C;CYP2A13;ADH1B;CYP2F1
41	central nervous system development (GO:0007417)	4/108	0.0232396	1.0000000	0	0	3.7037037	13.9329471	ROBO2;DCX;GRIK1;GPR124
42	ionotropic glutamate receptor signaling pathway (GO:0035235)	2/24	0.0237689	1.0000000	0	0	8.3333333	31.1614659	GRID1;GRIK1
43	regulation of natural killer cell mediated immunity (GO:0002715)	2/24	0.0237689	1.0000000	0	0	8.3333333	31.1614659	KLRK1;CRTAM
44	regulation of natural killer cell mediated cytotoxicity (GO:0042269)	2/24	0.0237689	1.0000000	0	0	8.3333333	31.1614659	KLRK1;CRTAM
45	regulation of smoothened signaling pathway (GO:0008589)	3/63	0.0252289	1.0000000	0	0	4.7619048	17.5226913	FGF9;HHIP;GPC3
46	positive regulation of smoothened signaling pathway (GO:0045880)	2/25	0.0256683	1.0000000	0	0	8.0000000	29.2999902	FGF9;GPC3
47	cellular response to vascular endothelial growth factor stimulus (GO:0035924)	2/25	0.0256683	1.0000000	0	0	8.0000000	29.2999902	RAMP2;FLT4
48	regulation of cell activation (GO:0050865)	9/420	0.0258303	1.0000000	0	0	2.1428571	7.8347273	KLRK1;CCL5;SFTPD;TRAC;SCGB1A1;ALOX12;BPI;HLA-DOA;HLA-DQB2
49	regulation of behavior (GO:0050795)	5/166	0.0258581	1.0000000	0	0	3.0120482	11.0094280	ROBO2;MC4R;GJA1;CCL5;GPR124
50	leukocyte migration (GO:0050900)	6/226	0.0263877	1.0000000	0	0	2.6548673	9.6500647	CX3CR1;PLA2G1B;PROS1;CCL5;SFTPD;JAM2
51	heart development (GO:0007507)	5/167	0.0264476	1.0000000	0	0	2.9940120	10.8760212	GJA1;RAMP2;SCUBE1;HOPX;FBN1
52	regulation of cAMP metabolic process (GO:0030814)	4/113	0.0268800	1.0000000	0	0	3.5398230	12.8013173	MC4R;NPPC;GABBR2;RAMP2
53	positive regulation of cell adhesion (GO:0045785)	5/171	0.0288909	1.0000000	0	0	2.9239766	10.3632401	SMOC2;ECM2;CCL5;ALOX12;DUSP26
54	neuron migration (GO:0001764)	4/116	0.0292190	1.0000000	0	0	3.4482759	12.1825356	GPM6A;GJA1;DCX;FEZF2
55	regulation of cyclic nucleotide biosynthetic process (GO:0030802)	4/116	0.0292190	1.0000000	0	0	3.4482759	12.1825356	MC4R;NPPC;GABBR2;RAMP2
56	angiogenesis (GO:0001525)	6/236	0.0316653	1.0000000	0	0	2.5423729	8.7776301	RAMP2;FGF9;FLT4;FGF18;TBX4;GPR124
57	regulation of purine nucleotide biosynthetic process (GO:1900371)	4/119	0.0316752	1.0000000	0	0	3.3613445	11.6041026	MC4R;NPPC;GABBR2;RAMP2
58	regulation of nucleotide biosynthetic process (GO:0030808)	4/119	0.0316752	1.0000000	0	0	3.3613445	11.6041026	MC4R;NPPC;GABBR2;RAMP2
59	negative regulation of smoothened signaling pathway (GO:0045879)	2/28	0.0317181	1.0000000	0	0	7.1428571	24.6490560	HHIP;GPC3
60	regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947)	2/28	0.0317181	1.0000000	0	0	7.1428571	24.6490560	FGF9;FGF18
61	adherens junction organization (GO:0034332)	3/69	0.0318810	1.0000000	0	0	4.3478261	14.9814966	RAMP2;DLC1;CDH7
62	regulation of cardiac muscle cell proliferation (GO:0060043)	2/29	0.0338475	1.0000000	0	0	6.8965517	23.3509763	GJA1;FGF9
63	anion transport (GO:0006820)	9/443	0.0345974	1.0000000	0	0	2.0316027	6.8342631	GJA1;FABP3;PLA2G1B;SLC6A13;SLC7A14;SLC4A10;GABRD;CLCA4;SLC38A4
64	adherens junction assembly (GO:0034333)	2/31	0.0382674	1.0000000	0	0	6.4516129	21.0526212	RAMP2;DLC1
65	T cell costimulation (GO:0031295)	3/76	0.0406839	1.0000000	0	0	3.9473684	12.6391704	KLRK1;TRAC;HLA-DQB2
66	regulation of smooth muscle cell proliferation (GO:0048660)	3/77	0.0420316	1.0000000	0	0	3.8961039	12.3480501	NPPC;CCL5;ALOX12
67	lymphocyte costimulation (GO:0031294)	3/77	0.0420316	1.0000000	0	0	3.8961039	12.3480501	KLRK1;TRAC;HLA-DQB2
68	regulation of leukocyte activation (GO:0002694)	8/390	0.0428832	1.0000000	0	0	2.0512821	6.4600523	KLRK1;CCL5;SFTPD;TRAC;SCGB1A1;BPI;HLA-DOA;HLA-DQB2
69	neuron recognition (GO:0008038)	2/33	0.0428940	1.0000000	0	0	6.0606061	19.0849967	ROBO2;FEZF2
70	cyclic purine nucleotide metabolic process (GO:0052652)	2/33	0.0428940	1.0000000	0	0	6.0606061	19.0849967	NPPC;RAMP2
71	regulation of cyclic nucleotide metabolic process (GO:0030799)	4/133	0.0447024	1.0000000	0	0	3.0075188	9.3465489	MC4R;NPPC;GABBR2;RAMP2
72	positive regulation of epithelial cell migration (GO:0010634)	3/79	0.0447938	1.0000000	0	0	3.7974684	11.7937443	FLT4;ALOX12;GPR124
73	regulation of membrane depolarization (GO:0003254)	2/34	0.0452816	1.0000000	0	0	5.8823529	18.2050300	GJA1;ALOX12
74	cyclic nucleotide biosynthetic process (GO:0009190)	2/34	0.0452816	1.0000000	0	0	5.8823529	18.2050300	NPPC;RAMP2
75	negative regulation of cell activation (GO:0050866)	4/135	0.0467746	1.0000000	0	0	2.9629630	9.0738214	SFTPD;SCGB1A1;ALOX12;BPI
76	organic anion transport (GO:0015711)	7/328	0.0473149	1.0000000	0	0	2.1341463	6.5111316	GJA1;FABP3;PLA2G1B;SLC6A13;SLC7A14;SLC4A10;SLC38A4
77	defense response to other organism (GO:0098542)	7/328	0.0473149	1.0000000	0	0	2.1341463	6.5111316	APOBEC3H;PLA2G1B;CD207;SFTPD;BPI;IFIT1;OASL
78	pyrimidine-containing compound catabolic process (GO:0072529)	2/35	0.0477172	1.0000000	0	0	5.7142857	17.3855107	APOBEC2;APOBEC3H
79	regulation of cardiac muscle tissue growth (GO:0055021)	2/35	0.0477172	1.0000000	0	0	5.7142857	17.3855107	GJA1;FGF9
80	regulation of endocrine process (GO:0044060)	2/35	0.0477172	1.0000000	0	0	5.7142857	17.3855107	KISS1;OR51E2
81	lung development (GO:0030324)	3/82	0.0491020	1.0000000	0	0	3.6585366	11.0263036	FGF18;GPC3;TBX4
82	positive regulation of cyclic nucleotide biosynthetic process (GO:0030804)	3/82	0.0491020	1.0000000	0	0	3.6585366	11.0263036	MC4R;NPPC;RAMP2
83	synaptic transmission, glutamatergic (GO:0035249)	2/36	0.0501995	1.0000000	0	0	5.5555556	16.6208344	GRID1;GRIK1
84	chemokine-mediated signaling pathway (GO:0070098)	2/36	0.0501995	1.0000000	0	0	5.5555556	16.6208344	CX3CR1;CCL5
85	positive regulation of purine nucleotide biosynthetic process (GO:1900373)	3/84	0.0520826	1.0000000	0	0	3.5714286	10.5532996	MC4R;NPPC;RAMP2
86	post-embryonic development (GO:0009791)	3/84	0.0520826	1.0000000	0	0	3.5714286	10.5532996	NPPC;SCUBE1;KCNJ1
87	positive regulation of nucleotide biosynthetic process (GO:0030810)	3/84	0.0520826	1.0000000	0	0	3.5714286	10.5532996	MC4R;NPPC;RAMP2
88	positive regulation of dephosphorylation (GO:0035306)	2/37	0.0527275	1.0000000	0	0	5.4054054	15.9060490	DLC1;DUSP26
89	leukotriene metabolic process (GO:0006691)	2/37	0.0527275	1.0000000	0	0	5.4054054	15.9060490	PLA2G1B;ALOX12
90	positive regulation of leukocyte mediated cytotoxicity (GO:0001912)	2/37	0.0527275	1.0000000	0	0	5.4054054	15.9060490	KLRK1;CRTAM
91	pyrimidine ribonucleoside metabolic process (GO:0046131)	2/37	0.0527275	1.0000000	0	0	5.4054054	15.9060490	APOBEC2;APOBEC3H
92	sodium ion transport (GO:0006814)	4/141	0.0533069	1.0000000	0	0	2.8368794	8.3168492	SLC5A7;SLC4A10;KCNJ1;SLC38A4
93	regulation of blood circulation (GO:1903522)	5/204	0.0544706	1.0000000	0	0	2.4509804	7.1325851	NPPC;GJA1;OR51E2;ALOX12;HOPX
94	embryonic limb morphogenesis (GO:0030326)	3/86	0.0551489	1.0000000	0	0	3.4883721	10.1083208	FGF9;GPC3;TBX4
95	positive regulation of Wnt signaling pathway (GO:0030177)	3/86	0.0551489	1.0000000	0	0	3.4883721	10.1083208	FGF9;GPC3;LGR5
96	embryonic appendage morphogenesis (GO:0035113)	3/86	0.0551489	1.0000000	0	0	3.4883721	10.1083208	FGF9;GPC3;TBX4
97	regulation of meiotic cell cycle (GO:0051445)	2/38	0.0552999	1.0000000	0	0	5.2631579	15.2367633	NPPC;DMRT1
98	lung alveolus development (GO:0048286)	2/38	0.0552999	1.0000000	0	0	5.2631579	15.2367633	SFTPD;HOPX
99	long-chain fatty acid transport (GO:0015909)	2/38	0.0552999	1.0000000	0	0	5.2631579	15.2367633	FABP3;PLA2G1B
100	regulation of multicellular organismal metabolic process (GO:0044246)	2/39	0.0579156	1.0000000	0	0	5.1282051	14.6090715	MC4R;MFAP4
101	regulation of lymphocyte activation (GO:0051249)	7/344	0.0581823	1.0000000	0	0	2.0348837	5.7875623	KLRK1;CCL5;SFTPD;TRAC;SCGB1A1;HLA-DOA;HLA-DQB2
102	cellular response to interferon-gamma (GO:0071346)	3/88	0.0582996	1.0000000	0	0	3.4090909	9.6891797	CCL5;HLA-DQB2;OASL
103	phototransduction, visible light (GO:0007603)	3/89	0.0599063	1.0000000	0	0	3.3707865	9.4886736	OPN1SW;CNGA1;GPC3
104	defense response to virus (GO:0051607)	4/147	0.0603096	1.0000000	0	0	2.7210884	7.6415355	APOBEC3H;CD207;IFIT1;OASL
105	telencephalon cell migration (GO:0022029)	2/40	0.0605735	1.0000000	0	0	5.0000000	14.0194887	CX3CR1;FEZF2
106	regulation of bone remodeling (GO:0046850)	2/40	0.0605735	1.0000000	0	0	5.0000000	14.0194887	MC4R;GJA1
107	glutamate receptor signaling pathway (GO:0007215)	2/40	0.0605735	1.0000000	0	0	5.0000000	14.0194887	GRID1;GRIK1
108	positive regulation of cyclic nucleotide metabolic process (GO:0030801)	3/91	0.0631816	1.0000000	0	0	3.2967033	9.1046463	MC4R;NPPC;RAMP2
109	chondrocyte differentiation (GO:0002062)	2/41	0.0632725	1.0000000	0	0	4.8780488	13.4648969	NPPC;FGF9
110	primary alcohol metabolic process (GO:0034308)	2/41	0.0632725	1.0000000	0	0	4.8780488	13.4648969	ADH1C;ADH1B
111	negative regulation of behavior (GO:0048521)	2/41	0.0632725	1.0000000	0	0	4.8780488	13.4648969	ROBO2;MC4R
112	regulation of heart growth (GO:0060420)	2/41	0.0632725	1.0000000	0	0	4.8780488	13.4648969	GJA1;FGF9
113	chloride transport (GO:0006821)	3/92	0.0648498	1.0000000	0	0	3.2608696	8.9207002	SLC4A10;GABRD;CLCA4
114	regulation of endothelial cell migration (GO:0010594)	3/92	0.0648498	1.0000000	0	0	3.2608696	8.9207002	FLT4;ALOX12;GPR124
115	response to drug (GO:0042493)	7/354	0.0656994	1.0000000	0	0	1.9774011	5.3838006	NPPC;FABP3;DDC;SCGB1A1;SNCG;KCNK3;ABCG2
116	icosanoid biosynthetic process (GO:0046456)	2/42	0.0660116	1.0000000	0	0	4.7619048	12.9424984	PLA2G1B;ALOX12
117	negative regulation of T cell proliferation (GO:0042130)	2/42	0.0660116	1.0000000	0	0	4.7619048	12.9424984	SFTPD;SCGB1A1
118	fatty acid derivative biosynthetic process (GO:1901570)	2/42	0.0660116	1.0000000	0	0	4.7619048	12.9424984	PLA2G1B;ALOX12
119	positive regulation of cell killing (GO:0031343)	2/42	0.0660116	1.0000000	0	0	4.7619048	12.9424984	KLRK1;CRTAM
120	regulation of viral process (GO:0050792)	4/152	0.0665001	1.0000000	0	0	2.6315789	7.1330304	APOBEC3H;CCL5;IFIT1;OASL
121	forebrain cell migration (GO:0021885)	2/43	0.0687896	1.0000000	0	0	4.6511628	12.4497769	CX3CR1;FEZF2
122	negative regulation of blood coagulation (GO:0030195)	2/43	0.0687896	1.0000000	0	0	4.6511628	12.4497769	PROS1;ALOX12
123	negative regulation of hemostasis (GO:1900047)	2/43	0.0687896	1.0000000	0	0	4.6511628	12.4497769	PROS1;ALOX12
124	cell chemotaxis (GO:0060326)	4/155	0.0703673	1.0000000	0	0	2.5806452	6.8491008	CX3CR1;PLA2G1B;CCL5;SFTPD
125	regulation of leukocyte mediated cytotoxicity (GO:0001910)	2/44	0.0716056	1.0000000	0	0	4.5454545	11.9844629	KLRK1;CRTAM
126	carboxylic acid transport (GO:0046942)	5/224	0.0747953	1.0000000	0	0	2.2321429	5.7879457	FABP3;PLA2G1B;SLC6A13;SLC7A14;SLC38A4
127	regulation of cAMP biosynthetic process (GO:0030817)	3/98	0.0752775	1.0000000	0	0	3.0612245	7.9180831	MC4R;GABBR2;RAMP2
128	protein oligomerization (GO:0051259)	7/366	0.0754631	1.0000000	0	0	1.9125683	4.9422889	GJA1;SCUBE1;CCL5;QPRT;KCNA3;KCNA4;TGM3
129	organic acid transport (GO:0015849)	5/226	0.0770271	1.0000000	0	0	2.2123894	5.6716780	FABP3;PLA2G1B;SLC6A13;SLC7A14;SLC38A4
130	cell junction assembly (GO:0034329)	4/160	0.0770636	1.0000000	0	0	2.5000000	6.4078112	GJA1;RAMP2;DLC1;CDH7
131	T cell receptor signaling pathway (GO:0050852)	3/99	0.0770836	1.0000000	0	0	3.0303030	7.7662575	TRAC;SKAP1;HLA-DQB2
132	positive regulation of male gonad development (GO:2000020)	1/8	0.0772681	1.0000000	0	0	12.5000000	32.0059307	DMRT1
133	activated T cell proliferation (GO:0050798)	1/8	0.0772681	1.0000000	0	0	12.5000000	32.0059307	CRTAM
134	purine ribonucleotide transport (GO:0015868)	1/8	0.0772681	1.0000000	0	0	12.5000000	32.0059307	GJA1
135	endothelium development (GO:0003158)	1/8	0.0772681	1.0000000	0	0	12.5000000	32.0059307	GJA1
136	negative regulation of cytosolic calcium ion concentration (GO:0051481)	1/8	0.0772681	1.0000000	0	0	12.5000000	32.0059307	KCNK3
137	regulation of vascular endothelial growth factor signaling pathway (GO:1900746)	1/8	0.0772681	1.0000000	0	0	12.5000000	32.0059307	GPR124
138	sequestering of extracellular ligand from receptor (GO:0035581)	1/8	0.0772681	1.0000000	0	0	12.5000000	32.0059307	FBN1
139	embryonic process involved in female pregnancy (GO:0060136)	1/8	0.0772681	1.0000000	0	0	12.5000000	32.0059307	ABCG2
140	cell proliferation involved in metanephros development (GO:0072203)	1/8	0.0772681	1.0000000	0	0	12.5000000	32.0059307	GPC3
141	regulation of chemokine-mediated signaling pathway (GO:0070099)	1/8	0.0772681	1.0000000	0	0	12.5000000	32.0059307	CCL5
142	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	1/8	0.0772681	1.0000000	0	0	12.5000000	32.0059307	HLA-DOA
143	regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)	1/8	0.0772681	1.0000000	0	0	12.5000000	32.0059307	GJA1
144	adenine nucleotide transport (GO:0051503)	1/8	0.0772681	1.0000000	0	0	12.5000000	32.0059307	GJA1
145	substrate-independent telencephalic tangential migration (GO:0021826)	1/8	0.0772681	1.0000000	0	0	12.5000000	32.0059307	FEZF2
146	positive regulation of protein kinase C signaling (GO:0090037)	1/8	0.0772681	1.0000000	0	0	12.5000000	32.0059307	FLT4
147	regulation of meiosis I (GO:0060631)	1/8	0.0772681	1.0000000	0	0	12.5000000	32.0059307	DMRT1
148	positive regulation of growth hormone secretion (GO:0060124)	1/8	0.0772681	1.0000000	0	0	12.5000000	32.0059307	KISS1
149	regulation of activation of Janus kinase activity (GO:0010533)	1/8	0.0772681	1.0000000	0	0	12.5000000	32.0059307	CCL5
150	cellular response to exogenous dsRNA (GO:0071360)	1/8	0.0772681	1.0000000	0	0	12.5000000	32.0059307	IFIT1
151	response to xenobiotic stimulus (GO:0009410)	1/8	0.0772681	1.0000000	0	0	12.5000000	32.0059307	SCGB1A1
152	citrulline biosynthetic process (GO:0019240)	1/8	0.0772681	1.0000000	0	0	12.5000000	32.0059307	PADI3
153	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	1/8	0.0772681	1.0000000	0	0	12.5000000	32.0059307	FEZF2
154	gap junction assembly (GO:0016264)	1/8	0.0772681	1.0000000	0	0	12.5000000	32.0059307	GJA1
155	positive regulation of immune response to tumor cell (GO:0002839)	1/8	0.0772681	1.0000000	0	0	12.5000000	32.0059307	CRTAM
156	regulation of response to tumor cell (GO:0002834)	1/8	0.0772681	1.0000000	0	0	12.5000000	32.0059307	CRTAM
157	regulation of immune response to tumor cell (GO:0002837)	1/8	0.0772681	1.0000000	0	0	12.5000000	32.0059307	CRTAM
158	positive regulation of response to tumor cell (GO:0002836)	1/8	0.0772681	1.0000000	0	0	12.5000000	32.0059307	CRTAM
159	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091)	1/8	0.0772681	1.0000000	0	0	12.5000000	32.0059307	APOBEC3H
160	positive regulation of muscle organ development (GO:0048636)	2/46	0.0773472	1.0000000	0	0	4.3478261	11.1280460	GJA1;FGF9
161	positive regulation of striated muscle tissue development (GO:0045844)	2/46	0.0773472	1.0000000	0	0	4.3478261	11.1280460	GJA1;FGF9
162	positive regulation of smooth muscle cell proliferation (GO:0048661)	2/46	0.0773472	1.0000000	0	0	4.3478261	11.1280460	CCL5;ALOX12
163	amino acid transmembrane transport (GO:0003333)	2/46	0.0773472	1.0000000	0	0	4.3478261	11.1280460	SLC7A14;SLC38A4
164	cell-cell junction organization (GO:0045216)	4/161	0.0784400	1.0000000	0	0	2.4844720	6.3240267	GJA1;RAMP2;DLC1;CDH7
165	negative regulation of coagulation (GO:0050819)	2/47	0.0802709	1.0000000	0	0	4.2553191	10.7333979	PROS1;ALOX12
166	keratinization (GO:0031424)	2/47	0.0802709	1.0000000	0	0	4.2553191	10.7333979	CNFN;TGM3
167	positive regulation of muscle tissue development (GO:1901863)	2/47	0.0802709	1.0000000	0	0	4.2553191	10.7333979	GJA1;FGF9
168	positive regulation of angiogenesis (GO:0045766)	3/101	0.0807525	1.0000000	0	0	2.9702970	7.4743550	CX3CR1;RAMP2;ALOX12
169	limb morphogenesis (GO:0035108)	3/101	0.0807525	1.0000000	0	0	2.9702970	7.4743550	FGF9;GPC3;TBX4
170	appendage morphogenesis (GO:0035107)	3/101	0.0807525	1.0000000	0	0	2.9702970	7.4743550	FGF9;GPC3;TBX4
171	regulation of cardiac muscle tissue development (GO:0055024)	2/48	0.0832284	1.0000000	0	0	4.1666667	10.3590263	GJA1;FGF9
172	stem cell proliferation (GO:0072089)	2/48	0.0832284	1.0000000	0	0	4.1666667	10.3590263	HHIP;GPC3
173	fatty acid transport (GO:0015908)	2/49	0.0862189	1.0000000	0	0	4.0816327	10.0035323	FABP3;PLA2G1B
174	monocarboxylic acid transport (GO:0015718)	3/104	0.0863951	1.0000000	0	0	2.8846154	7.0639147	FABP3;PLA2G1B;SLC6A13
175	detection of visible light (GO:0009584)	3/104	0.0863951	1.0000000	0	0	2.8846154	7.0639147	OPN1SW;CNGA1;GPC3
176	negative regulation of cellular response to growth factor stimulus (GO:0090288)	3/104	0.0863951	1.0000000	0	0	2.8846154	7.0639147	PEG10;FBN1;GPR124
177	gamma-aminobutyric acid transport (GO:0015812)	1/9	0.0864991	1.0000000	0	0	11.1111111	27.1957962	SLC6A13
178	regulation of chronic inflammatory response (GO:0002676)	1/9	0.0864991	1.0000000	0	0	11.1111111	27.1957962	CCL5
179	heme transport (GO:0015886)	1/9	0.0864991	1.0000000	0	0	11.1111111	27.1957962	ABCG2
180	regulation of gonadotropin secretion (GO:0032276)	1/9	0.0864991	1.0000000	0	0	11.1111111	27.1957962	KISS1
181	alkaloid metabolic process (GO:0009820)	1/9	0.0864991	1.0000000	0	0	11.1111111	27.1957962	DDC
182	lymph vessel development (GO:0001945)	1/9	0.0864991	1.0000000	0	0	11.1111111	27.1957962	FLT4
183	regulation of helicase activity (GO:0051095)	1/9	0.0864991	1.0000000	0	0	11.1111111	27.1957962	IFIT1
184	regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)	1/9	0.0864991	1.0000000	0	0	11.1111111	27.1957962	GPR124
185	negative regulation of homotypic cell-cell adhesion (GO:0034111)	1/9	0.0864991	1.0000000	0	0	11.1111111	27.1957962	ALOX12
186	regulation of phospholipase A2 activity (GO:0032429)	1/9	0.0864991	1.0000000	0	0	11.1111111	27.1957962	PLA2G1B
187	atrial cardiac muscle cell action potential (GO:0086014)	1/9	0.0864991	1.0000000	0	0	11.1111111	27.1957962	GJA1
188	DNA deamination (GO:0045006)	1/9	0.0864991	1.0000000	0	0	11.1111111	27.1957962	APOBEC3H
189	response to pheromone (GO:0019236)	1/9	0.0864991	1.0000000	0	0	11.1111111	27.1957962	TMEM145
190	opioid receptor signaling pathway (GO:0038003)	1/9	0.0864991	1.0000000	0	0	11.1111111	27.1957962	NPBWR1
191	positive regulation of amino acid transport (GO:0051957)	1/9	0.0864991	1.0000000	0	0	11.1111111	27.1957962	GRIK1
192	eosinophil chemotaxis (GO:0048245)	1/9	0.0864991	1.0000000	0	0	11.1111111	27.1957962	CCL5
193	regulation of multi-organism process (GO:0043900)	6/306	0.0874918	1.0000000	0	0	1.9607843	4.7768817	NPPC;CD8B;APOBEC3H;CCL5;IFIT1;OASL
194	response to fatty acid (GO:0070542)	2/50	0.0892415	1.0000000	0	0	4.0000000	9.6656385	FABP3;OR51E2
195	negative regulation of wound healing (GO:0061045)	2/50	0.0892415	1.0000000	0	0	4.0000000	9.6656385	PROS1;ALOX12
196	regulation of cell killing (GO:0031341)	2/50	0.0892415	1.0000000	0	0	4.0000000	9.6656385	KLRK1;CRTAM
197	positive regulation of protein secretion (GO:0050714)	3/106	0.0902475	1.0000000	0	0	2.8301887	6.8071667	PLA2G1B;CRTAM;OR51E2
198	cell growth (GO:0016049)	3/106	0.0902475	1.0000000	0	0	2.8301887	6.8071667	NDRG4;DCX;EMP1
199	regulation of wound healing (GO:0061041)	3/107	0.0922004	1.0000000	0	0	2.8037383	6.6835268	PROS1;ALOX12;HOPX
200	regulation of response to biotic stimulus (GO:0002831)	3/107	0.0922004	1.0000000	0	0	2.8037383	6.6835268	CD8B;CRTAM;IFIT1
201	unsaturated fatty acid biosynthetic process (GO:0006636)	2/51	0.0922950	1.0000000	0	0	3.9215686	9.3441758	PLA2G1B;ALOX12
202	negative regulation of immune system process (GO:0002683)	6/311	0.0927754	1.0000000	0	0	1.9292605	4.5869588	SFTPD;SCGB1A1;BPI;UBASH3A;IFIT1;HLA-DOA
203	response to other organism (GO:0051707)	8/462	0.0932984	1.0000000	0	0	1.7316017	4.1072776	APOBEC3H;PLA2G1B;CCL5;CD207;SFTPD;BPI;IFIT1;OASL
204	response to interferon-gamma (GO:0034341)	3/108	0.0941707	1.0000000	0	0	2.7777778	6.5629070	CCL5;HLA-DQB2;OASL
205	anion transmembrane transport (GO:0098656)	4/172	0.0943786	1.0000000	0	0	2.3255814	5.4893965	SLC7A14;GABRD;CLCA4;SLC38A4
206	nitrogen compound transport (GO:0071705)	8/464	0.0950459	1.0000000	0	0	1.7241379	4.0575780	MC4R;SLC5A7;GJA1;DDC;SLC6A13;SLC7A14;ABCG2;SLC38A4
207	negative regulation of stress fiber assembly (GO:0051497)	1/10	0.0956382	1.0000000	0	0	10.0000000	23.4718325	DLC1
208	regulation of glomerular filtration (GO:0003093)	1/10	0.0956382	1.0000000	0	0	10.0000000	23.4718325	GJA1
209	regulation of T cell chemotaxis (GO:0010819)	1/10	0.0956382	1.0000000	0	0	10.0000000	23.4718325	CCL5
210	regulation of macrophage chemotaxis (GO:0010758)	1/10	0.0956382	1.0000000	0	0	10.0000000	23.4718325	CCL5
211	positive regulation of T cell chemotaxis (GO:0010820)	1/10	0.0956382	1.0000000	0	0	10.0000000	23.4718325	CCL5
212	cardiovascular system development (GO:0072358)	1/10	0.0956382	1.0000000	0	0	10.0000000	23.4718325	KCNJ1
213	surfactant homeostasis (GO:0043129)	1/10	0.0956382	1.0000000	0	0	10.0000000	23.4718325	SFTPD
214	aggressive behavior (GO:0002118)	1/10	0.0956382	1.0000000	0	0	10.0000000	23.4718325	SNCG
215	negative regulation of cardiac muscle tissue growth (GO:0055022)	1/10	0.0956382	1.0000000	0	0	10.0000000	23.4718325	GJA1
216	purine nucleotide transport (GO:0015865)	1/10	0.0956382	1.0000000	0	0	10.0000000	23.4718325	GJA1
217	positive regulation of endothelial cell differentiation (GO:0045603)	1/10	0.0956382	1.0000000	0	0	10.0000000	23.4718325	ALOX12
218	regulation of tight junction assembly (GO:2000810)	1/10	0.0956382	1.0000000	0	0	10.0000000	23.4718325	GJA1
219	negative regulation of gluconeogenesis (GO:0045721)	1/10	0.0956382	1.0000000	0	0	10.0000000	23.4718325	LEPR
220	phospholipid homeostasis (GO:0055091)	1/10	0.0956382	1.0000000	0	0	10.0000000	23.4718325	FABP3
221	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	1/10	0.0956382	1.0000000	0	0	10.0000000	23.4718325	GRIK1
222	response to insecticide (GO:0017085)	1/10	0.0956382	1.0000000	0	0	10.0000000	23.4718325	DDC
223	positive regulation of vasculogenesis (GO:2001214)	1/10	0.0956382	1.0000000	0	0	10.0000000	23.4718325	RAMP2
224	regulation of male gonad development (GO:2000018)	1/10	0.0956382	1.0000000	0	0	10.0000000	23.4718325	DMRT1
225	eosinophil migration (GO:0072677)	1/10	0.0956382	1.0000000	0	0	10.0000000	23.4718325	CCL5
226	positive regulation of monocyte chemotaxis (GO:0090026)	1/10	0.0956382	1.0000000	0	0	10.0000000	23.4718325	CCL5
227	regulation of mononuclear cell migration (GO:0071675)	1/10	0.0956382	1.0000000	0	0	10.0000000	23.4718325	CCL5
228	regulation of phospholipid biosynthetic process (GO:0071071)	1/10	0.0956382	1.0000000	0	0	10.0000000	23.4718325	FABP3
229	negative regulation of heart growth (GO:0061117)	1/10	0.0956382	1.0000000	0	0	10.0000000	23.4718325	GJA1
230	lymphangiogenesis (GO:0001946)	1/10	0.0956382	1.0000000	0	0	10.0000000	23.4718325	FLT4
231	resolution of meiotic recombination intermediates (GO:0000712)	1/10	0.0956382	1.0000000	0	0	10.0000000	23.4718325	MEIOB
232	long-chain fatty acid biosynthetic process (GO:0042759)	1/10	0.0956382	1.0000000	0	0	10.0000000	23.4718325	ALOX12
233	regulation of ion transmembrane transport (GO:0034765)	6/314	0.0960269	1.0000000	0	0	1.9108280	4.4773126	GJA1;KCNJ6;KCNA3;KCNA4;KCNJ1;KCNK3
234	phototransduction (GO:0007602)	3/109	0.0961583	1.0000000	0	0	2.7522936	6.4452104	OPN1SW;CNGA1;GPC3
235	cell recognition (GO:0008037)	3/109	0.0961583	1.0000000	0	0	2.7522936	6.4452104	ROBO2;CRTAM;FEZF2
236	regulation of symbiosis, encompassing mutualism through parasitism (GO:0043903)	4/174	0.0974299	1.0000000	0	0	2.2988506	5.3531543	APOBEC3H;CCL5;IFIT1;OASL
237	negative regulation of lymphocyte proliferation (GO:0050672)	2/53	0.0984918	1.0000000	0	0	3.7735849	8.7463472	SFTPD;SCGB1A1
238	negative regulation of mononuclear cell proliferation (GO:0032945)	2/53	0.0984918	1.0000000	0	0	3.7735849	8.7463472	SFTPD;SCGB1A1
239	granulocyte chemotaxis (GO:0071621)	2/53	0.0984918	1.0000000	0	0	3.7735849	8.7463472	PLA2G1B;CCL5
240	fatty acid biosynthetic process (GO:0006633)	3/111	0.1001846	1.0000000	0	0	2.7027027	6.2182191	CH25H;PLA2G1B;ALOX12
241	cytosolic calcium ion homeostasis (GO:0051480)	4/176	0.1005270	1.0000000	0	0	2.2727273	5.2212019	KISS1;CD52;GJA1;KCNK3
242	response to insulin (GO:0032868)	5/246	0.1012805	1.0000000	0	0	2.0325203	4.6541895	MC4R;FABP3;FGF9;PLA2G1B;FGF18
243	pyrimidine nucleoside metabolic process (GO:0006213)	2/54	0.1016332	1.0000000	0	0	3.7037037	8.4680937	APOBEC2;APOBEC3H
244	negative regulation of vascular permeability (GO:0043116)	1/11	0.1046863	1.0000000	0	0	9.0909091	20.5162457	RAMP2
245	negative regulation of meiosis (GO:0045835)	1/11	0.1046863	1.0000000	0	0	9.0909091	20.5162457	DMRT1
246	regulation of timing of cell differentiation (GO:0048505)	1/11	0.1046863	1.0000000	0	0	9.0909091	20.5162457	FGF9
247	receptor guanylyl cyclase signaling pathway (GO:0007168)	1/11	0.1046863	1.0000000	0	0	9.0909091	20.5162457	NPPC
248	negative regulation of Rho protein signal transduction (GO:0035024)	1/11	0.1046863	1.0000000	0	0	9.0909091	20.5162457	DLC1
249	dopamine biosynthetic process (GO:0042416)	1/11	0.1046863	1.0000000	0	0	9.0909091	20.5162457	DDC
250	nephron epithelium morphogenesis (GO:0072088)	1/11	0.1046863	1.0000000	0	0	9.0909091	20.5162457	GPC3
251	nephron tubule morphogenesis (GO:0072078)	1/11	0.1046863	1.0000000	0	0	9.0909091	20.5162457	GPC3
252	regulation of growth hormone secretion (GO:0060123)	1/11	0.1046863	1.0000000	0	0	9.0909091	20.5162457	KISS1
253	lung-associated mesenchyme development (GO:0060484)	1/11	0.1046863	1.0000000	0	0	9.0909091	20.5162457	FGF9
254	regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)	1/11	0.1046863	1.0000000	0	0	9.0909091	20.5162457	GPC3
255	germ cell migration (GO:0008354)	1/11	0.1046863	1.0000000	0	0	9.0909091	20.5162457	DMRT1
256	response to folic acid (GO:0051593)	1/11	0.1046863	1.0000000	0	0	9.0909091	20.5162457	ABCG2
257	serotonin metabolic process (GO:0042428)	1/11	0.1046863	1.0000000	0	0	9.0909091	20.5162457	DDC
258	cell proliferation involved in kidney development (GO:0072111)	1/11	0.1046863	1.0000000	0	0	9.0909091	20.5162457	GPC3
259	mRNA modification (GO:0016556)	1/11	0.1046863	1.0000000	0	0	9.0909091	20.5162457	APOBEC2
260	skeletal muscle tissue regeneration (GO:0043403)	1/11	0.1046863	1.0000000	0	0	9.0909091	20.5162457	GJA1
261	basement membrane organization (GO:0071711)	1/11	0.1046863	1.0000000	0	0	9.0909091	20.5162457	RAMP2
262	granulocyte migration (GO:0097530)	2/55	0.1048020	1.0000000	0	0	3.6363636	8.2024799	PLA2G1B;CCL5
263	regulation of angiogenesis (GO:0045765)	4/179	0.1052574	1.0000000	0	0	2.2346369	5.0309424	CX3CR1;RAMP2;ALOX12;GPR124
264	neuropeptide signaling pathway (GO:0007218)	3/114	0.1063488	1.0000000	0	0	2.6315789	5.8974502	NPBWR1;SCG5;GPR124
265	response to virus (GO:0009615)	5/250	0.1065424	1.0000000	0	0	2.0000000	4.4784239	APOBEC3H;CCL5;CD207;IFIT1;OASL
266	negative regulation of leukocyte proliferation (GO:0070664)	2/56	0.1079976	1.0000000	0	0	3.5714286	7.9487379	SFTPD;SCGB1A1
267	regulation of transmembrane transport (GO:0034762)	6/327	0.1108102	1.0000000	0	0	1.8348624	4.0365800	GJA1;KCNJ6;KCNA3;KCNA4;KCNJ1;KCNK3
268	neurotransmitter secretion (GO:0007269)	2/57	0.1112189	1.0000000	0	0	3.5087719	7.7061583	SLC5A7;SLC6A13
269	UV protection (GO:0009650)	1/12	0.1136443	1.0000000	0	0	8.3333333	18.1223455	MFAP4
270	microglial cell activation (GO:0001774)	1/12	0.1136443	1.0000000	0	0	8.3333333	18.1223455	CX3CR1
271	extracellular fibril organization (GO:0043206)	1/12	0.1136443	1.0000000	0	0	8.3333333	18.1223455	MFAP4
272	chemical homeostasis within a tissue (GO:0048875)	1/12	0.1136443	1.0000000	0	0	8.3333333	18.1223455	SFTPD
273	peptidyl-glutamic acid carboxylation (GO:0017187)	1/12	0.1136443	1.0000000	0	0	8.3333333	18.1223455	PROS1
274	regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)	1/12	0.1136443	1.0000000	0	0	8.3333333	18.1223455	GJA1
275	regulation of interleukin-13 production (GO:0032656)	1/12	0.1136443	1.0000000	0	0	8.3333333	18.1223455	SCGB1A1
276	positive regulation of synaptic transmission, GABAergic (GO:0032230)	1/12	0.1136443	1.0000000	0	0	8.3333333	18.1223455	GRIK1
277	citrulline metabolic process (GO:0000052)	1/12	0.1136443	1.0000000	0	0	8.3333333	18.1223455	PADI3
278	positive regulation of T cell apoptotic process (GO:0070234)	1/12	0.1136443	1.0000000	0	0	8.3333333	18.1223455	CCL5
279	iron coordination entity transport (GO:1901678)	1/12	0.1136443	1.0000000	0	0	8.3333333	18.1223455	ABCG2
280	regulation of development, heterochronic (GO:0040034)	1/12	0.1136443	1.0000000	0	0	8.3333333	18.1223455	FGF9
281	response to water (GO:0009415)	1/12	0.1136443	1.0000000	0	0	8.3333333	18.1223455	SNCG
282	neutrophil mediated immunity (GO:0002446)	1/12	0.1136443	1.0000000	0	0	8.3333333	18.1223455	PLA2G1B
283	regulation of platelet aggregation (GO:0090330)	1/12	0.1136443	1.0000000	0	0	8.3333333	18.1223455	ALOX12
284	toxin metabolic process (GO:0009404)	1/12	0.1136443	1.0000000	0	0	8.3333333	18.1223455	DDC
285	negative regulation by host of viral transcription (GO:0043922)	1/12	0.1136443	1.0000000	0	0	8.3333333	18.1223455	CCL5
286	body morphogenesis (GO:0010171)	1/12	0.1136443	1.0000000	0	0	8.3333333	18.1223455	GPC3
287	protein carboxylation (GO:0018214)	1/12	0.1136443	1.0000000	0	0	8.3333333	18.1223455	PROS1
288	linoleic acid metabolic process (GO:0043651)	1/12	0.1136443	1.0000000	0	0	8.3333333	18.1223455	ALOX12
289	synapsis (GO:0007129)	1/12	0.1136443	1.0000000	0	0	8.3333333	18.1223455	MEIOB
290	neuron-neuron synaptic transmission (GO:0007270)	2/58	0.1144652	1.0000000	0	0	3.4482759	7.4740853	GRID1;GRIK1
291	cyclic nucleotide metabolic process (GO:0009187)	2/58	0.1144652	1.0000000	0	0	3.4482759	7.4740853	NPPC;RAMP2
292	regulation of transmembrane receptor protein serine/threonine kinase signaling pathway (GO:0090092)	4/186	0.1166797	1.0000000	0	0	2.1505376	4.6200488	DMRT1;PEG10;GPC3;FBN1
293	positive regulation of canonical Wnt signaling pathway (GO:0090263)	2/59	0.1177356	1.0000000	0	0	3.3898305	7.2519111	FGF9;LGR5
294	response to fibroblast growth factor (GO:0071774)	4/187	0.1183543	1.0000000	0	0	2.1390374	4.5648613	FGF9;CCL5;FGF18;SCGB1A1
295	regulation of chemotaxis (GO:0050920)	3/120	0.1191064	1.0000000	0	0	2.5000000	5.3193443	ROBO2;CCL5;GPR124
296	negative regulation of leukocyte activation (GO:0002695)	3/120	0.1191064	1.0000000	0	0	2.5000000	5.3193443	SFTPD;SCGB1A1;BPI
297	regulation of amine transport (GO:0051952)	2/60	0.1210294	1.0000000	0	0	3.3333333	7.0390725	SNCG;GRIK1
298	detection of light stimulus (GO:0009583)	3/121	0.1212860	1.0000000	0	0	2.4793388	5.2304234	OPN1SW;CNGA1;GPC3
299	cellular calcium ion homeostasis (GO:0006874)	5/261	0.1216875	1.0000000	0	0	1.9157088	4.0350552	KISS1;CD52;GJA1;CCL5;KCNK3
300	regulation of cell adhesion (GO:0030155)	6/336	0.1216895	1.0000000	0	0	1.7857143	3.7612194	SMOC2;ECM2;CCL5;ALOX12;DUSP26;JAM2
301	cell junction organization (GO:0034330)	4/189	0.1217348	1.0000000	0	0	2.1164021	4.4569531	GJA1;RAMP2;DLC1;CDH7
302	positive regulation of T cell activation (GO:0050870)	4/189	0.1217348	1.0000000	0	0	2.1164021	4.4569531	KLRK1;CCL5;TRAC;HLA-DQB2
303	positive regulation of antigen processing and presentation (GO:0002579)	1/13	0.1225132	1.0000000	0	0	7.6923077	16.1502800	HLA-DQB2
304	primary amino compound metabolic process (GO:1901160)	1/13	0.1225132	1.0000000	0	0	7.6923077	16.1502800	DDC
305	chronic inflammatory response (GO:0002544)	1/13	0.1225132	1.0000000	0	0	7.6923077	16.1502800	GJA1
306	negative regulation of actin filament bundle assembly (GO:0032232)	1/13	0.1225132	1.0000000	0	0	7.6923077	16.1502800	DLC1
307	mesenchymal cell proliferation (GO:0010463)	1/13	0.1225132	1.0000000	0	0	7.6923077	16.1502800	GPC3
308	peptidyl-proline hydroxylation (GO:0019511)	1/13	0.1225132	1.0000000	0	0	7.6923077	16.1502800	P4HA3
309	urate metabolic process (GO:0046415)	1/13	0.1225132	1.0000000	0	0	7.6923077	16.1502800	ABCG2
310	oocyte development (GO:0048599)	1/13	0.1225132	1.0000000	0	0	7.6923077	16.1502800	DMRT1
311	macrophage activation involved in immune response (GO:0002281)	1/13	0.1225132	1.0000000	0	0	7.6923077	16.1502800	CX3CR1
312	protein-chromophore linkage (GO:0018298)	1/13	0.1225132	1.0000000	0	0	7.6923077	16.1502800	OPN1SW
313	lipoxygenase pathway (GO:0019372)	1/13	0.1225132	1.0000000	0	0	7.6923077	16.1502800	ALOX12
314	regulation of cell maturation (GO:1903429)	1/13	0.1225132	1.0000000	0	0	7.6923077	16.1502800	NPPC
315	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	1/13	0.1225132	1.0000000	0	0	7.6923077	16.1502800	GRIK1
316	renal absorption (GO:0070293)	1/13	0.1225132	1.0000000	0	0	7.6923077	16.1502800	KCNJ1
317	positive regulation of translational initiation (GO:0045948)	1/13	0.1225132	1.0000000	0	0	7.6923077	16.1502800	CCL5
318	vascular endothelial growth factor signaling pathway (GO:0038084)	1/13	0.1225132	1.0000000	0	0	7.6923077	16.1502800	FLT4
319	kidney development (GO:0001822)	3/122	0.1234802	1.0000000	0	0	2.4590164	5.1434622	ROBO2;KCNJ1;FBN1
320	regulation of immune effector process (GO:0002697)	5/264	0.1259849	1.0000000	0	0	1.8939394	3.9234726	KLRK1;CD8B;PROS1;CRTAM;IFIT1
321	signal release (GO:0023061)	3/124	0.1279118	1.0000000	0	0	2.4193548	4.9751966	MC4R;SLC5A7;SLC6A13
322	cytokine-mediated signaling pathway (GO:0019221)	6/342	0.1292261	1.0000000	0	0	1.7543860	3.5898106	CX3CR1;CCL5;LEPR;IFIT1;HLA-DQB2;OASL
323	regulation of T cell proliferation (GO:0042129)	3/125	0.1301487	1.0000000	0	0	2.4000000	4.8937858	CCL5;SFTPD;SCGB1A1
324	regulation of vasculogenesis (GO:2001212)	1/14	0.1312938	1.0000000	0	0	7.1428571	14.5022708	RAMP2
325	cell communication by electrical coupling (GO:0010644)	1/14	0.1312938	1.0000000	0	0	7.1428571	14.5022708	GJA1
326	superoxide anion generation (GO:0042554)	1/14	0.1312938	1.0000000	0	0	7.1428571	14.5022708	ALOX12
327	regulation of endothelial cell differentiation (GO:0045601)	1/14	0.1312938	1.0000000	0	0	7.1428571	14.5022708	ALOX12
328	regulation of non-canonical Wnt signaling pathway (GO:2000050)	1/14	0.1312938	1.0000000	0	0	7.1428571	14.5022708	GPC3
329	regulation of feeding behavior (GO:0060259)	1/14	0.1312938	1.0000000	0	0	7.1428571	14.5022708	MC4R
330	positive regulation of bone resorption (GO:0045780)	1/14	0.1312938	1.0000000	0	0	7.1428571	14.5022708	MC4R
331	arachidonic acid secretion (GO:0050482)	1/14	0.1312938	1.0000000	0	0	7.1428571	14.5022708	PLA2G1B
332	positive regulation of meiosis (GO:0045836)	1/14	0.1312938	1.0000000	0	0	7.1428571	14.5022708	DMRT1
333	Sertoli cell development (GO:0060009)	1/14	0.1312938	1.0000000	0	0	7.1428571	14.5022708	DMRT1
334	fibril organization (GO:0097435)	1/14	0.1312938	1.0000000	0	0	7.1428571	14.5022708	MFAP4
335	positive regulation of bone remodeling (GO:0046852)	1/14	0.1312938	1.0000000	0	0	7.1428571	14.5022708	MC4R
336	regulation of monocyte chemotaxis (GO:0090025)	1/14	0.1312938	1.0000000	0	0	7.1428571	14.5022708	CCL5
337	peptidyl-arginine modification (GO:0018195)	1/14	0.1312938	1.0000000	0	0	7.1428571	14.5022708	PADI3
338	icosanoid secretion (GO:0032309)	1/14	0.1312938	1.0000000	0	0	7.1428571	14.5022708	PLA2G1B
339	cellular response to zinc ion (GO:0071294)	1/14	0.1312938	1.0000000	0	0	7.1428571	14.5022708	KCNK3
340	negative regulation of interleukin-8 production (GO:0032717)	1/14	0.1312938	1.0000000	0	0	7.1428571	14.5022708	BPI
341	negative regulation of T cell receptor signaling pathway (GO:0050860)	1/14	0.1312938	1.0000000	0	0	7.1428571	14.5022708	UBASH3A
342	regulation of dephosphorylation (GO:0035303)	3/126	0.1323995	1.0000000	0	0	2.3809524	4.8141217	DLC1;SLC7A14;DUSP26
343	fatty acid oxidation (GO:0019395)	2/64	0.1344226	1.0000000	0	0	3.1250000	6.2711468	ACOXL;ALOX12
344	inorganic anion transport (GO:0015698)	3/127	0.1346640	1.0000000	0	0	2.3622047	4.7361558	SLC4A10;GABRD;CLCA4
345	antigen receptor-mediated signaling pathway (GO:0050851)	3/127	0.1346640	1.0000000	0	0	2.3622047	4.7361558	TRAC;SKAP1;HLA-DQB2
346	regulation of vasculature development (GO:1901342)	4/197	0.1356621	1.0000000	0	0	2.0304569	4.0560163	CX3CR1;RAMP2;ALOX12;GPR124
347	cellular divalent inorganic cation homeostasis (GO:0072503)	5/271	0.1362797	1.0000000	0	0	1.8450185	3.6772068	KISS1;CD52;GJA1;CCL5;KCNK3
348	amino acid transport (GO:0006865)	3/128	0.1369418	1.0000000	0	0	2.3437500	4.6598412	SLC6A13;SLC7A14;SLC38A4
349	lipid oxidation (GO:0034440)	2/65	0.1378216	1.0000000	0	0	3.0769231	6.0978319	ACOXL;ALOX12
350	cellular response to type I interferon (GO:0071357)	2/65	0.1378216	1.0000000	0	0	3.0769231	6.0978319	IFIT1;OASL
351	positive regulation of cAMP biosynthetic process (GO:0030819)	2/65	0.1378216	1.0000000	0	0	3.0769231	6.0978319	MC4R;RAMP2
352	interferon-gamma-mediated signaling pathway (GO:0060333)	2/65	0.1378216	1.0000000	0	0	3.0769231	6.0978319	HLA-DQB2;OASL
353	type I interferon signaling pathway (GO:0060337)	2/65	0.1378216	1.0000000	0	0	3.0769231	6.0978319	IFIT1;OASL
354	regulation of epithelial cell migration (GO:0010632)	3/129	0.1392329	1.0000000	0	0	2.3255814	4.5851326	FLT4;ALOX12;GPR124
355	positive regulation of secretion (GO:0051047)	5/273	0.1392883	1.0000000	0	0	1.8315018	3.6102742	KISS1;PLA2G1B;CRTAM;OR51E2;GRIK1
356	regulation of mitochondrial depolarization (GO:0051900)	1/15	0.1399869	1.0000000	0	0	6.6666667	13.1080425	ALOX12
357	chondrocyte development (GO:0002063)	1/15	0.1399869	1.0000000	0	0	6.6666667	13.1080425	FGF18
358	cellular response to dsRNA (GO:0071359)	1/15	0.1399869	1.0000000	0	0	6.6666667	13.1080425	IFIT1
359	extracellular matrix assembly (GO:0085029)	1/15	0.1399869	1.0000000	0	0	6.6666667	13.1080425	MFAP4
360	extracellular negative regulation of signal transduction (GO:1900116)	1/15	0.1399869	1.0000000	0	0	6.6666667	13.1080425	FBN1
361	DNA demethylation (GO:0080111)	1/15	0.1399869	1.0000000	0	0	6.6666667	13.1080425	APOBEC2
362	positive regulation of lymphocyte apoptotic process (GO:0070230)	1/15	0.1399869	1.0000000	0	0	6.6666667	13.1080425	CCL5
363	renal tubule morphogenesis (GO:0061333)	1/15	0.1399869	1.0000000	0	0	6.6666667	13.1080425	GPC3
364	positive regulation of smooth muscle cell migration (GO:0014911)	1/15	0.1399869	1.0000000	0	0	6.6666667	13.1080425	CCL5
365	positive regulation of meiotic cell cycle (GO:0051446)	1/15	0.1399869	1.0000000	0	0	6.6666667	13.1080425	DMRT1
366	extracellular regulation of signal transduction (GO:1900115)	1/15	0.1399869	1.0000000	0	0	6.6666667	13.1080425	FBN1
367	positive regulation of T-helper 1 type immune response (GO:0002827)	1/15	0.1399869	1.0000000	0	0	6.6666667	13.1080425	HLA-DQB2
368	renal system process involved in regulation of blood volume (GO:0001977)	1/15	0.1399869	1.0000000	0	0	6.6666667	13.1080425	GJA1
369	regulation of interleukin-5 production (GO:0032674)	1/15	0.1399869	1.0000000	0	0	6.6666667	13.1080425	SCGB1A1
370	dicarboxylic acid catabolic process (GO:0043649)	1/15	0.1399869	1.0000000	0	0	6.6666667	13.1080425	QPRT
371	negative regulation of platelet activation (GO:0010544)	1/15	0.1399869	1.0000000	0	0	6.6666667	13.1080425	ALOX12
372	negative regulation of interleukin-2 production (GO:0032703)	1/15	0.1399869	1.0000000	0	0	6.6666667	13.1080425	SFTPD
373	response to UV-B (GO:0010224)	1/15	0.1399869	1.0000000	0	0	6.6666667	13.1080425	MFAP4
374	nucleoside transport (GO:0015858)	1/15	0.1399869	1.0000000	0	0	6.6666667	13.1080425	GJA1
375	calcium ion homeostasis (GO:0055074)	5/274	0.1408035	1.0000000	0	0	1.8248175	3.5773538	KISS1;CD52;GJA1;CCL5;KCNK3
376	response to type I interferon (GO:0034340)	2/66	0.1412394	1.0000000	0	0	3.0303030	5.9312088	IFIT1;OASL
377	response to acid chemical (GO:0001101)	5/275	0.1423260	1.0000000	0	0	1.8181818	3.5447908	FABP3;OR51E2;SCGB1A1;SNCG;ABCG2
378	negative regulation of hydrolase activity (GO:0051346)	6/354	0.1449554	1.0000000	0	0	1.6949153	3.2734398	PROS1;SLC7A14;GPC3;LEPR;A2ML1;IFIT1
379	nervous system development (GO:0007399)	5/277	0.1453926	1.0000000	0	0	1.8050542	3.4807180	BEX1;DOK5;FGF18;DCX;GRIK1
380	regulation of developmental growth (GO:0048638)	3/133	0.1485253	1.0000000	0	0	2.2556391	4.3015042	GJA1;FGF9;HOPX
381	protein hydroxylation (GO:0018126)	1/16	0.1485935	1.0000000	0	0	6.2500000	11.9158813	P4HA3
382	positive regulation of cell adhesion mediated by integrin (GO:0033630)	1/16	0.1485935	1.0000000	0	0	6.2500000	11.9158813	CCL5
383	phosphatidylinositol acyl-chain remodeling (GO:0036149)	1/16	0.1485935	1.0000000	0	0	6.2500000	11.9158813	PLA2G1B
384	dentate gyrus development (GO:0021542)	1/16	0.1485935	1.0000000	0	0	6.2500000	11.9158813	FEZF2
385	cAMP biosynthetic process (GO:0006171)	1/16	0.1485935	1.0000000	0	0	6.2500000	11.9158813	RAMP2
386	epithelial cell maturation (GO:0002070)	1/16	0.1485935	1.0000000	0	0	6.2500000	11.9158813	GJA1
387	cochlea development (GO:0090102)	1/16	0.1485935	1.0000000	0	0	6.2500000	11.9158813	KCNK3
388	negative regulation of cardiac muscle tissue development (GO:0055026)	1/16	0.1485935	1.0000000	0	0	6.2500000	11.9158813	GJA1
389	behavioral response to pain (GO:0048266)	1/16	0.1485935	1.0000000	0	0	6.2500000	11.9158813	GRIK1
390	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway (GO:0051482)	1/16	0.1485935	1.0000000	0	0	6.2500000	11.9158813	KISS1
391	negative regulation of defense response to virus (GO:0050687)	1/16	0.1485935	1.0000000	0	0	6.2500000	11.9158813	IFIT1
392	establishment of skin barrier (GO:0061436)	1/16	0.1485935	1.0000000	0	0	6.2500000	11.9158813	ALOX12
393	myeloid leukocyte mediated immunity (GO:0002444)	1/16	0.1485935	1.0000000	0	0	6.2500000	11.9158813	PLA2G1B
394	regulation of protein kinase C signaling (GO:0090036)	1/16	0.1485935	1.0000000	0	0	6.2500000	11.9158813	FLT4
395	neuroblast proliferation (GO:0007405)	1/16	0.1485935	1.0000000	0	0	6.2500000	11.9158813	HHIP
396	cGMP biosynthetic process (GO:0006182)	1/16	0.1485935	1.0000000	0	0	6.2500000	11.9158813	NPPC
397	drug transmembrane transport (GO:0006855)	1/16	0.1485935	1.0000000	0	0	6.2500000	11.9158813	ABCG2
398	dendritic cell chemotaxis (GO:0002407)	1/16	0.1485935	1.0000000	0	0	6.2500000	11.9158813	CCL5
399	multicellular organismal aging (GO:0010259)	1/16	0.1485935	1.0000000	0	0	6.2500000	11.9158813	DDC
400	regulation of lymphocyte chemotaxis (GO:1901623)	1/16	0.1485935	1.0000000	0	0	6.2500000	11.9158813	CCL5
401	respiratory burst (GO:0045730)	1/16	0.1485935	1.0000000	0	0	6.2500000	11.9158813	CD52
402	fatty acid metabolic process (GO:0006631)	5/280	0.1500455	1.0000000	0	0	1.7857143	3.3871721	CH25H;FABP3;ACOXL;PLA2G1B;ALOX12
403	positive regulation of lymphocyte mediated immunity (GO:0002708)	2/69	0.1515988	1.0000000	0	0	2.8985507	5.4681675	KLRK1;CRTAM
404	extracellular matrix organization (GO:0030198)	6/359	0.1517582	1.0000000	0	0	1.6713092	3.1511980	SMOC2;MFAP4;RAMP2;ECM2;JAM2;FBN1
405	inorganic cation transmembrane transport (GO:0098662)	7/440	0.1531269	1.0000000	0	0	1.5909091	2.9853222	GPM6A;KCNJ6;KCNA3;CNGA1;KCNA4;KCNJ1;KCNK3
406	extracellular structure organization (GO:0043062)	6/360	0.1531358	1.0000000	0	0	1.6666667	3.1273836	SMOC2;MFAP4;RAMP2;ECM2;JAM2;FBN1
407	cellular metal ion homeostasis (GO:0006875)	6/361	0.1545190	1.0000000	0	0	1.6620499	3.1037753	KISS1;CD52;GJA1;CCL5;KCNK3;ABCG2
408	leukocyte mediated immunity (GO:0002443)	2/70	0.1550849	1.0000000	0	0	2.8571429	5.3250926	PLA2G1B;CRTAM
409	phosphatidylglycerol acyl-chain remodeling (GO:0036148)	1/17	0.1571144	1.0000000	0	0	5.8823529	10.8869493	PLA2G1B
410	forebrain neuron development (GO:0021884)	1/17	0.1571144	1.0000000	0	0	5.8823529	10.8869493	ROBO2
411	male meiosis I (GO:0007141)	1/17	0.1571144	1.0000000	0	0	5.8823529	10.8869493	MEIOB
412	trophectodermal cell differentiation (GO:0001829)	1/17	0.1571144	1.0000000	0	0	5.8823529	10.8869493	HOPX
413	phosphatidylserine acyl-chain remodeling (GO:0036150)	1/17	0.1571144	1.0000000	0	0	5.8823529	10.8869493	PLA2G1B
414	synaptic transmission, cholinergic (GO:0007271)	1/17	0.1571144	1.0000000	0	0	5.8823529	10.8869493	SLC5A7
415	fatty acid derivative transport (GO:1901571)	1/17	0.1571144	1.0000000	0	0	5.8823529	10.8869493	PLA2G1B
416	NAD biosynthetic process (GO:0009435)	1/17	0.1571144	1.0000000	0	0	5.8823529	10.8869493	QPRT
417	monocyte chemotaxis (GO:0002548)	1/17	0.1571144	1.0000000	0	0	5.8823529	10.8869493	CCL5
418	icosanoid transport (GO:0071715)	1/17	0.1571144	1.0000000	0	0	5.8823529	10.8869493	PLA2G1B
419	sex differentiation (GO:0007548)	1/17	0.1571144	1.0000000	0	0	5.8823529	10.8869493	DMRT1
420	neurotransmitter biosynthetic process (GO:0042136)	1/17	0.1571144	1.0000000	0	0	5.8823529	10.8869493	SLC5A7
421	regulation of G-protein coupled receptor protein signaling pathway (GO:0008277)	3/137	0.1580124	1.0000000	0	0	2.1897810	4.0403245	RAMP2;CCL5;CNGA1
422	positive regulation of developmental growth (GO:0048639)	2/71	0.1585864	1.0000000	0	0	2.8169014	5.1871985	FGF9;HOPX
423	renal system process (GO:0003014)	2/71	0.1585864	1.0000000	0	0	2.8169014	5.1871985	GJA1;KCNJ1
424	response to peptide hormone (GO:0043434)	6/364	0.1587019	1.0000000	0	0	1.6483516	3.0341663	MC4R;GJA1;FABP3;FGF9;PLA2G1B;FGF18
425	DNA modification (GO:0006304)	2/72	0.1621027	1.0000000	0	0	2.7777778	5.0542366	APOBEC2;APOBEC3H
426	positive regulation of cAMP metabolic process (GO:0030816)	2/72	0.1621027	1.0000000	0	0	2.7777778	5.0542366	MC4R;RAMP2
427	positive regulation of peptidase activity (GO:0010952)	3/139	0.1628250	1.0000000	0	0	2.1582734	3.9174379	PCOLCE2;DLC1;ALOX12
428	negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)	1/18	0.1655504	1.0000000	0	0	5.5555556	9.9915545	UBASH3A
429	axonal fasciculation (GO:0007413)	1/18	0.1655504	1.0000000	0	0	5.5555556	9.9915545	FEZF2
430	indolalkylamine metabolic process (GO:0006586)	1/18	0.1655504	1.0000000	0	0	5.5555556	9.9915545	DDC
431	embryonic digestive tract development (GO:0048566)	1/18	0.1655504	1.0000000	0	0	5.5555556	9.9915545	FGF9
432	positive regulation of cGMP biosynthetic process (GO:0030828)	1/18	0.1655504	1.0000000	0	0	5.5555556	9.9915545	NPPC
433	catechol-containing compound biosynthetic process (GO:0009713)	1/18	0.1655504	1.0000000	0	0	5.5555556	9.9915545	DDC
434	negative regulation of T cell apoptotic process (GO:0070233)	1/18	0.1655504	1.0000000	0	0	5.5555556	9.9915545	CCL5
435	catecholamine biosynthetic process (GO:0042423)	1/18	0.1655504	1.0000000	0	0	5.5555556	9.9915545	DDC
436	regulation of dopamine secretion (GO:0014059)	1/18	0.1655504	1.0000000	0	0	5.5555556	9.9915545	SNCG
437	fibrinolysis (GO:0042730)	1/18	0.1655504	1.0000000	0	0	5.5555556	9.9915545	PROS1
438	positive regulation of chondrocyte differentiation (GO:0032332)	1/18	0.1655504	1.0000000	0	0	5.5555556	9.9915545	FGF18
439	DNA dealkylation (GO:0035510)	1/18	0.1655504	1.0000000	0	0	5.5555556	9.9915545	APOBEC2
440	negative regulation of transforming growth factor beta receptor signaling pathway (GO:0030512)	2/73	0.1656331	1.0000000	0	0	2.7397260	4.9259739	PEG10;FBN1
441	regulation of BMP signaling pathway (GO:0030510)	2/73	0.1656331	1.0000000	0	0	2.7397260	4.9259739	GPC3;FBN1
442	negative regulation of T cell activation (GO:0050868)	2/73	0.1656331	1.0000000	0	0	2.7397260	4.9259739	SFTPD;SCGB1A1
443	divalent inorganic cation homeostasis (GO:0072507)	5/291	0.1676310	1.0000000	0	0	1.7182131	3.0687119	KISS1;CD52;GJA1;CCL5;KCNK3
444	regulation of system process (GO:0044057)	6/371	0.1686521	1.0000000	0	0	1.6172507	2.8785729	KISS1;NPPC;GJA1;OR51E2;ALOX12;HOPX
445	negative regulation of response to external stimulus (GO:0032102)	4/215	0.1691759	1.0000000	0	0	1.8604651	3.3057044	ROBO2;PROS1;ALOX12;IFIT1
446	regulation of organ growth (GO:0046620)	2/74	0.1691769	1.0000000	0	0	2.7027027	4.8021906	GJA1;FGF9
447	blood vessel morphogenesis (GO:0048514)	2/74	0.1691769	1.0000000	0	0	2.7027027	4.8021906	GJA1;FLT4
448	regulation of peptidase activity (GO:0052547)	6/372	0.1700947	1.0000000	0	0	1.6129032	2.8570965	PCOLCE2;DLC1;PROS1;GPC3;ALOX12;A2ML1
449	response to toxic substance (GO:0009636)	3/142	0.1701252	1.0000000	0	0	2.1126761	3.7420149	DDC;CCL5;CYP2F1
450	neutrophil activation (GO:0042119)	1/19	0.1739024	1.0000000	0	0	5.2631579	9.2066381	CCL5
451	nucleotide transport (GO:0006862)	1/19	0.1739024	1.0000000	0	0	5.2631579	9.2066381	GJA1
452	reflex (GO:0060004)	1/19	0.1739024	1.0000000	0	0	5.2631579	9.2066381	GJA1
453	regulation of water loss via skin (GO:0033561)	1/19	0.1739024	1.0000000	0	0	5.2631579	9.2066381	ALOX12
454	regulation of cGMP biosynthetic process (GO:0030826)	1/19	0.1739024	1.0000000	0	0	5.2631579	9.2066381	NPPC
455	regulation of execution phase of apoptosis (GO:1900117)	1/19	0.1739024	1.0000000	0	0	5.2631579	9.2066381	DLC1
456	innate immune response in mucosa (GO:0002227)	1/19	0.1739024	1.0000000	0	0	5.2631579	9.2066381	PLA2G1B
457	regulation of interleukin-2 biosynthetic process (GO:0045076)	1/19	0.1739024	1.0000000	0	0	5.2631579	9.2066381	SFTPD
458	retinal ganglion cell axon guidance (GO:0031290)	1/19	0.1739024	1.0000000	0	0	5.2631579	9.2066381	ROBO2
459	cell-cell junction assembly (GO:0007043)	2/77	0.1798830	1.0000000	0	0	2.5974026	4.4557106	GJA1;RAMP2
460	regulation of defense response to virus (GO:0050688)	2/77	0.1798830	1.0000000	0	0	2.5974026	4.4557106	CD8B;IFIT1
461	multi-organism behavior (GO:0051705)	2/77	0.1798830	1.0000000	0	0	2.5974026	4.4557106	GRID1;SNCG
462	modulation by host of viral transcription (GO:0043921)	1/20	0.1821712	1.0000000	0	0	5.0000000	8.5140422	CCL5
463	modulation by host of symbiont transcription (GO:0052472)	1/20	0.1821712	1.0000000	0	0	5.0000000	8.5140422	CCL5
464	T cell mediated immunity (GO:0002456)	1/20	0.1821712	1.0000000	0	0	5.0000000	8.5140422	CRTAM
465	cellular biogenic amine biosynthetic process (GO:0042401)	1/20	0.1821712	1.0000000	0	0	5.0000000	8.5140422	DDC
466	positive regulation of cGMP metabolic process (GO:0030825)	1/20	0.1821712	1.0000000	0	0	5.0000000	8.5140422	NPPC
467	regulation of membrane repolarization (GO:0060306)	1/20	0.1821712	1.0000000	0	0	5.0000000	8.5140422	GJA1
468	negative regulation of endothelial cell apoptotic process (GO:2000352)	1/20	0.1821712	1.0000000	0	0	5.0000000	8.5140422	RAMP2
469	renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)	1/20	0.1821712	1.0000000	0	0	5.0000000	8.5140422	GJA1
470	positive regulation of cardiac muscle cell proliferation (GO:0060045)	1/20	0.1821712	1.0000000	0	0	5.0000000	8.5140422	FGF9
471	nicotinamide nucleotide biosynthetic process (GO:0019359)	1/20	0.1821712	1.0000000	0	0	5.0000000	8.5140422	QPRT
472	neuromuscular synaptic transmission (GO:0007274)	1/20	0.1821712	1.0000000	0	0	5.0000000	8.5140422	SLC5A7
473	epithelial tube branching involved in lung morphogenesis (GO:0060441)	1/20	0.1821712	1.0000000	0	0	5.0000000	8.5140422	HHIP
474	sialylation (GO:0097503)	1/20	0.1821712	1.0000000	0	0	5.0000000	8.5140422	ST6GAL2
475	pyridine nucleotide biosynthetic process (GO:0019363)	1/20	0.1821712	1.0000000	0	0	5.0000000	8.5140422	QPRT
476	positive regulation of T cell migration (GO:2000406)	1/20	0.1821712	1.0000000	0	0	5.0000000	8.5140422	CCL5
477	regulation of amino acid transport (GO:0051955)	1/20	0.1821712	1.0000000	0	0	5.0000000	8.5140422	GRIK1
478	positive regulation of leukocyte mediated immunity (GO:0002705)	2/78	0.1834746	1.0000000	0	0	2.5641026	4.3478946	KLRK1;CRTAM
479	ovulation cycle process (GO:0022602)	2/78	0.1834746	1.0000000	0	0	2.5641026	4.3478946	ROBO2;KISS1
480	cation homeostasis (GO:0055080)	7/465	0.1855520	1.0000000	0	0	1.5053763	2.5356861	KISS1;CD52;GJA1;CCL5;SLC4A10;KCNK3;ABCG2
481	regulation of blood coagulation (GO:0030193)	2/79	0.1870767	1.0000000	0	0	2.5316456	4.2436366	PROS1;ALOX12
482	regulation of hemostasis (GO:1900046)	2/79	0.1870767	1.0000000	0	0	2.5316456	4.2436366	PROS1;ALOX12
483	response to peptide (GO:1901652)	6/384	0.1878023	1.0000000	0	0	1.5625000	2.6130713	MC4R;GJA1;FABP3;FGF9;PLA2G1B;FGF18
484	modulation of transcription in other organism involved in symbiotic interaction (GO:0052312)	1/21	0.1903576	1.0000000	0	0	4.7619048	7.8992886	CCL5
485	amine biosynthetic process (GO:0009309)	1/21	0.1903576	1.0000000	0	0	4.7619048	7.8992886	DDC
486	bile acid biosynthetic process (GO:0006699)	1/21	0.1903576	1.0000000	0	0	4.7619048	7.8992886	CH25H
487	dendritic cell migration (GO:0036336)	1/21	0.1903576	1.0000000	0	0	4.7619048	7.8992886	CCL5
488	granulocyte activation (GO:0036230)	1/21	0.1903576	1.0000000	0	0	4.7619048	7.8992886	CCL5
489	regulation of T-helper 1 type immune response (GO:0002825)	1/21	0.1903576	1.0000000	0	0	4.7619048	7.8992886	HLA-DQB2
490	regulation of interleukin-4 production (GO:0032673)	1/21	0.1903576	1.0000000	0	0	4.7619048	7.8992886	SCGB1A1
491	positive regulation of phospholipase activity (GO:0010518)	2/80	0.1906887	1.0000000	0	0	2.5000000	4.1427819	PLA2G1B;CCL5
492	negative regulation of DNA metabolic process (GO:0051053)	2/80	0.1906887	1.0000000	0	0	2.5000000	4.1427819	NPPC;APOBEC3H
493	retinoid metabolic process (GO:0001523)	2/81	0.1943101	1.0000000	0	0	2.4691358	4.0451846	OPN1SW;GPC3
494	pyrimidine-containing compound metabolic process (GO:0072527)	2/81	0.1943101	1.0000000	0	0	2.4691358	4.0451846	APOBEC2;APOBEC3H
495	positive regulation of viral process (GO:0048524)	2/81	0.1943101	1.0000000	0	0	2.4691358	4.0451846	CCL5;IFIT1
496	regulation of canonical Wnt signaling pathway (GO:0060828)	3/152	0.1950998	1.0000000	0	0	1.9736842	3.2254818	FGF9;GPC3;LGR5
497	positive regulation of cytosolic calcium ion concentration (GO:0007204)	3/152	0.1950998	1.0000000	0	0	1.9736842	3.2254818	KISS1;CD52;GJA1
498	receptor-mediated endocytosis (GO:0006898)	3/152	0.1950998	1.0000000	0	0	1.9736842	3.2254818	RAMP2;SFTPD;LRP1B
499	cellular cation homeostasis (GO:0030003)	6/389	0.1953866	1.0000000	0	0	1.5424165	2.5184188	KISS1;CD52;GJA1;CCL5;KCNK3;ABCG2
500	male meiosis (GO:0007140)	1/22	0.1984626	1.0000000	0	0	4.5454545	7.3507034	MEIOB
501	regulation of cGMP metabolic process (GO:0030823)	1/22	0.1984626	1.0000000	0	0	4.5454545	7.3507034	NPPC
502	positive regulation of cardiac muscle tissue growth (GO:0055023)	1/22	0.1984626	1.0000000	0	0	4.5454545	7.3507034	FGF9
503	central nervous system projection neuron axonogenesis (GO:0021952)	1/22	0.1984626	1.0000000	0	0	4.5454545	7.3507034	DCX
504	meiosis I (GO:0007127)	1/22	0.1984626	1.0000000	0	0	4.5454545	7.3507034	MEIOB
505	myofibril assembly (GO:0030239)	1/22	0.1984626	1.0000000	0	0	4.5454545	7.3507034	MYOZ1
506	apoptotic process involved in development (GO:1902742)	1/22	0.1984626	1.0000000	0	0	4.5454545	7.3507034	ROBO2
507	organic hydroxy compound metabolic process (GO:1901615)	7/476	0.2006601	1.0000000	0	0	1.4705882	2.3619745	CH25H;DDC;ADH1C;ADH1B;PLA2G1B;LEPR;ALOX12
508	cellular response to abiotic stimulus (GO:0071214)	4/232	0.2031974	1.0000000	0	0	1.7241379	2.7475468	MFAP4;GJA1;CNGA1;SNCG
509	positive regulation of MAPK cascade (GO:0043410)	6/395	0.2046385	1.0000000	0	0	1.5189873	2.4098887	KISS1;FGF9;PLA2G1B;FLT4;DIRAS2;FGF18
510	reactive oxygen species metabolic process (GO:0072593)	2/84	0.2052251	1.0000000	0	0	2.3809524	3.7705904	SFTPD;ALOX12
511	chloride transmembrane transport (GO:1902476)	2/84	0.2052251	1.0000000	0	0	2.3809524	3.7705904	GABRD;CLCA4
512	DNA catabolic process, exonucleolytic (GO:0000738)	1/23	0.2064868	1.0000000	0	0	4.3478261	6.8587782	MEIOB
513	endothelial cell differentiation (GO:0045446)	1/23	0.2064868	1.0000000	0	0	4.3478261	6.8587782	SCUBE1
514	cell-substrate adherens junction assembly (GO:0007045)	1/23	0.2064868	1.0000000	0	0	4.3478261	6.8587782	DLC1
515	focal adhesion assembly (GO:0048041)	1/23	0.2064868	1.0000000	0	0	4.3478261	6.8587782	DLC1
516	regulation of macrophage activation (GO:0043030)	1/23	0.2064868	1.0000000	0	0	4.3478261	6.8587782	BPI
517	detection of biotic stimulus (GO:0009595)	1/23	0.2064868	1.0000000	0	0	4.3478261	6.8587782	CRTAM
518	phosphatidylethanolamine acyl-chain remodeling (GO:0036152)	1/23	0.2064868	1.0000000	0	0	4.3478261	6.8587782	PLA2G1B
519	regulation of activin receptor signaling pathway (GO:0032925)	1/23	0.2064868	1.0000000	0	0	4.3478261	6.8587782	DMRT1
520	positive regulation vascular endothelial growth factor production (GO:0010575)	1/23	0.2064868	1.0000000	0	0	4.3478261	6.8587782	FLT4
521	drug transport (GO:0015893)	1/23	0.2064868	1.0000000	0	0	4.3478261	6.8587782	ABCG2
522	positive regulation of organic acid transport (GO:0032892)	1/23	0.2064868	1.0000000	0	0	4.3478261	6.8587782	GRIK1
523	negative regulation of organ growth (GO:0046621)	1/23	0.2064868	1.0000000	0	0	4.3478261	6.8587782	GJA1
524	regulation of T cell migration (GO:2000404)	1/23	0.2064868	1.0000000	0	0	4.3478261	6.8587782	CCL5
525	positive regulation of amine transport (GO:0051954)	1/23	0.2064868	1.0000000	0	0	4.3478261	6.8587782	GRIK1
526	regulation of coagulation (GO:0050818)	2/85	0.2088786	1.0000000	0	0	2.3529412	3.6847110	PROS1;ALOX12
527	female pregnancy (GO:0007565)	2/85	0.2088786	1.0000000	0	0	2.3529412	3.6847110	RAMP2;SCGB1A1
528	positive regulation of synaptic transmission (GO:0050806)	2/85	0.2088786	1.0000000	0	0	2.3529412	3.6847110	KISS1;GRIK1
529	cellular response to light stimulus (GO:0071482)	2/85	0.2088786	1.0000000	0	0	2.3529412	3.6847110	MFAP4;CNGA1
530	single organismal cell-cell adhesion (GO:0016337)	4/235	0.2094034	1.0000000	0	0	1.7021277	2.6612640	CCL5;ANXA9;JAM2;CDH7
531	regulation of reproductive process (GO:2000241)	2/86	0.2125388	1.0000000	0	0	2.3255814	3.6014667	NPPC;DMRT1
532	myeloid leukocyte activation (GO:0002274)	2/86	0.2125388	1.0000000	0	0	2.3255814	3.6014667	CX3CR1;CCL5
533	vascular process in circulatory system (GO:0003018)	2/86	0.2125388	1.0000000	0	0	2.3255814	3.6014667	NPPC;RAMP2
534	positive regulation of filopodium assembly (GO:0051491)	1/24	0.2144310	1.0000000	0	0	4.1666667	6.4156966	GPM6A
535	mucosal immune response (GO:0002385)	1/24	0.2144310	1.0000000	0	0	4.1666667	6.4156966	PLA2G1B
536	vascular endothelial growth factor receptor signaling pathway (GO:0048010)	1/24	0.2144310	1.0000000	0	0	4.1666667	6.4156966	FLT4
537	positive regulation of leukocyte apoptotic process (GO:2000108)	1/24	0.2144310	1.0000000	0	0	4.1666667	6.4156966	CCL5
538	gamma-aminobutyric acid signaling pathway (GO:0007214)	1/24	0.2144310	1.0000000	0	0	4.1666667	6.4156966	GABBR2
539	negative regulation of adenylate cyclase activity (GO:0007194)	1/24	0.2144310	1.0000000	0	0	4.1666667	6.4156966	GABBR2
540	regulation of fatty acid oxidation (GO:0046320)	1/24	0.2144310	1.0000000	0	0	4.1666667	6.4156966	FABP3
541	negative regulation of muscle cell apoptotic process (GO:0010656)	1/24	0.2144310	1.0000000	0	0	4.1666667	6.4156966	ALOX12
542	leukotriene biosynthetic process (GO:0019370)	1/24	0.2144310	1.0000000	0	0	4.1666667	6.4156966	PLA2G1B
543	cofactor transport (GO:0051181)	1/24	0.2144310	1.0000000	0	0	4.1666667	6.4156966	ABCG2
544	cGMP metabolic process (GO:0046068)	1/24	0.2144310	1.0000000	0	0	4.1666667	6.4156966	NPPC
545	pyridine-containing compound biosynthetic process (GO:0072525)	1/24	0.2144310	1.0000000	0	0	4.1666667	6.4156966	QPRT
546	negative regulation of viral transcription (GO:0032897)	1/24	0.2144310	1.0000000	0	0	4.1666667	6.4156966	CCL5
547	positive regulation of response to biotic stimulus (GO:0002833)	1/24	0.2144310	1.0000000	0	0	4.1666667	6.4156966	CRTAM
548	positive regulation of lymphocyte migration (GO:2000403)	1/24	0.2144310	1.0000000	0	0	4.1666667	6.4156966	CCL5
549	cellular ion homeostasis (GO:0006873)	6/402	0.2156295	1.0000000	0	0	1.4925373	2.2898409	KISS1;CD52;GJA1;CCL5;KCNK3;ABCG2
550	regulation of ion homeostasis (GO:2000021)	3/160	0.2156879	1.0000000	0	0	1.8750000	2.8761054	GJA1;PLA2G1B;ALOX12
551	diterpenoid metabolic process (GO:0016101)	2/87	0.2162053	1.0000000	0	0	2.2988506	3.5207517	OPN1SW;GPC3
552	regulation of protein secretion (GO:0050708)	3/161	0.2182939	1.0000000	0	0	1.8633540	2.8358630	PLA2G1B;CRTAM;OR51E2
553	regulation of ERK1 and ERK2 cascade (GO:0070372)	3/161	0.2182939	1.0000000	0	0	1.8633540	2.8358630	FLT4;FGF18;DUSP26
554	fatty acid derivative metabolic process (GO:1901568)	2/88	0.2198775	1.0000000	0	0	2.2727273	3.4424652	PLA2G1B;ALOX12
555	icosanoid metabolic process (GO:0006690)	2/88	0.2198775	1.0000000	0	0	2.2727273	3.4424652	PLA2G1B;ALOX12
556	membrane hyperpolarization (GO:0060081)	1/25	0.2222961	1.0000000	0	0	4.0000000	6.0149794	GRIK1
557	peptidyl-glutamic acid modification (GO:0018200)	1/25	0.2222961	1.0000000	0	0	4.0000000	6.0149794	PROS1
558	regulation of T cell receptor signaling pathway (GO:0050856)	1/25	0.2222961	1.0000000	0	0	4.0000000	6.0149794	UBASH3A
559	regulation of potassium ion transmembrane transporter activity (GO:1901016)	1/25	0.2222961	1.0000000	0	0	4.0000000	6.0149794	KCNJ1
560	negative regulation of cyclase activity (GO:0031280)	1/25	0.2222961	1.0000000	0	0	4.0000000	6.0149794	GABBR2
561	osteoclast differentiation (GO:0030316)	1/25	0.2222961	1.0000000	0	0	4.0000000	6.0149794	GPC3
562	positive regulation of heart growth (GO:0060421)	1/25	0.2222961	1.0000000	0	0	4.0000000	6.0149794	FGF9
563	response to iron ion (GO:0010039)	1/25	0.2222961	1.0000000	0	0	4.0000000	6.0149794	ABCG2
564	positive regulation of cartilage development (GO:0061036)	1/25	0.2222961	1.0000000	0	0	4.0000000	6.0149794	FGF18
565	regulation of autophagy (GO:0010506)	2/89	0.2235550	1.0000000	0	0	2.2471910	3.3665119	SOGA3;KIAA0408
566	regulation of phospholipase activity (GO:0010517)	2/89	0.2235550	1.0000000	0	0	2.2471910	3.3665119	PLA2G1B;CCL5
567	protein tetramerization (GO:0051262)	2/89	0.2235550	1.0000000	0	0	2.2471910	3.3665119	CCL5;TGM3
568	positive regulation of lymphocyte activation (GO:0051251)	4/243	0.2262091	1.0000000	0	0	1.6460905	2.4465772	KLRK1;CCL5;TRAC;HLA-DQB2
569	epithelial tube morphogenesis (GO:0060562)	2/90	0.2272373	1.0000000	0	0	2.2222222	3.2928009	GJA1;GPC3
570	positive regulation of lipase activity (GO:0060193)	2/90	0.2272373	1.0000000	0	0	2.2222222	3.2928009	PLA2G1B;CCL5
571	regulation of neurotransmitter levels (GO:0001505)	2/90	0.2272373	1.0000000	0	0	2.2222222	3.2928009	SLC5A7;SLC6A13
572	positive regulation of endocytosis (GO:0045807)	2/90	0.2272373	1.0000000	0	0	2.2222222	3.2928009	SFTPD;GPC3
573	macrophage activation (GO:0042116)	1/26	0.2300829	1.0000000	0	0	3.8461538	5.6512139	CX3CR1
574	indole-containing compound metabolic process (GO:0042430)	1/26	0.2300829	1.0000000	0	0	3.8461538	5.6512139	DDC
575	positive regulation of vasoconstriction (GO:0045907)	1/26	0.2300829	1.0000000	0	0	3.8461538	5.6512139	GJA1
576	leukocyte mediated cytotoxicity (GO:0001909)	1/26	0.2300829	1.0000000	0	0	3.8461538	5.6512139	CRTAM
577	regulation of defense response to virus by host (GO:0050691)	1/26	0.2300829	1.0000000	0	0	3.8461538	5.6512139	IFIT1
578	phosphatidylcholine acyl-chain remodeling (GO:0036151)	1/26	0.2300829	1.0000000	0	0	3.8461538	5.6512139	PLA2G1B
579	positive regulation of tissue remodeling (GO:0034105)	1/26	0.2300829	1.0000000	0	0	3.8461538	5.6512139	MC4R
580	negative regulation of lyase activity (GO:0051350)	1/26	0.2300829	1.0000000	0	0	3.8461538	5.6512139	GABBR2
581	negative regulation of response to biotic stimulus (GO:0002832)	1/26	0.2300829	1.0000000	0	0	3.8461538	5.6512139	IFIT1
582	organ or tissue specific immune response (GO:0002251)	1/26	0.2300829	1.0000000	0	0	3.8461538	5.6512139	PLA2G1B
583	antibacterial humoral response (GO:0019731)	1/26	0.2300829	1.0000000	0	0	3.8461538	5.6512139	PLA2G1B
584	positive regulation of calcium ion transport (GO:0051928)	2/91	0.2309240	1.0000000	0	0	2.1978022	3.2212458	PLA2G1B;CCL5
585	organic hydroxy compound biosynthetic process (GO:1901617)	3/166	0.2314186	1.0000000	0	0	1.8072289	2.6449282	CH25H;DDC;ALOX12
586	growth (GO:0040007)	5/329	0.2338375	1.0000000	0	0	1.5197568	2.2084028	GJA1;NDRG4;ST6GAL2;DCX;EMP1
587	monocarboxylic acid biosynthetic process (GO:0072330)	3/167	0.2340613	1.0000000	0	0	1.7964072	2.6086929	CH25H;PLA2G1B;ALOX12
588	positive regulation of secretion by cell (GO:1903532)	4/247	0.2347399	1.0000000	0	0	1.6194332	2.3470074	KISS1;PLA2G1B;CRTAM;OR51E2
589	secretion by cell (GO:0032940)	6/415	0.2365598	1.0000000	0	0	1.4457831	2.0841749	MC4R;SLC5A7;PROS1;CCL5;SLC6A13;SNCG
590	phosphatidylserine metabolic process (GO:0006658)	1/27	0.2377921	1.0000000	0	0	3.7037037	5.3198467	PLA2G1B
591	regulation of vascular permeability (GO:0043114)	1/27	0.2377921	1.0000000	0	0	3.7037037	5.3198467	RAMP2
592	negative regulation of chemotaxis (GO:0050922)	1/27	0.2377921	1.0000000	0	0	3.7037037	5.3198467	ROBO2
593	regulation of complement activation (GO:0030449)	1/27	0.2377921	1.0000000	0	0	3.7037037	5.3198467	PROS1
594	negative regulation of interferon-gamma production (GO:0032689)	1/27	0.2377921	1.0000000	0	0	3.7037037	5.3198467	SCGB1A1
595	regulation of vascular endothelial growth factor production (GO:0010574)	1/27	0.2377921	1.0000000	0	0	3.7037037	5.3198467	FLT4
596	negative regulation of lymphocyte apoptotic process (GO:0070229)	1/27	0.2377921	1.0000000	0	0	3.7037037	5.3198467	CCL5
597	regulation of platelet activation (GO:0010543)	1/27	0.2377921	1.0000000	0	0	3.7037037	5.3198467	ALOX12
598	cellular response to fatty acid (GO:0071398)	1/27	0.2377921	1.0000000	0	0	3.7037037	5.3198467	OR51E2
599	neurotransmitter metabolic process (GO:0042133)	1/27	0.2377921	1.0000000	0	0	3.7037037	5.3198467	SLC5A7
600	positive regulation of cell-substrate adhesion (GO:0010811)	2/93	0.2383085	1.0000000	0	0	2.1505376	3.0842782	SMOC2;ECM2
601	antigen processing and presentation of exogenous peptide antigen via MHC class II (GO:0019886)	2/93	0.2383085	1.0000000	0	0	2.1505376	3.0842782	HLA-DOA;HLA-DQB2
602	regulation of metal ion transport (GO:0010959)	4/250	0.2411890	1.0000000	0	0	1.6000000	2.2754791	GJA1;PLA2G1B;CCL5;KCNJ1
603	regulation of cell-cell adhesion (GO:0022407)	2/94	0.2420055	1.0000000	0	0	2.1276596	3.0187127	CCL5;ALOX12
604	antigen processing and presentation of peptide antigen via MHC class II (GO:0002495)	2/94	0.2420055	1.0000000	0	0	2.1276596	3.0187127	HLA-DOA;HLA-DQB2
605	regulation of lymphocyte proliferation (GO:0050670)	3/170	0.2420212	1.0000000	0	0	1.7647059	2.5036409	CCL5;SFTPD;SCGB1A1
606	regulation of calcium ion transport (GO:0051924)	3/171	0.2446846	1.0000000	0	0	1.7543860	2.4697984	GJA1;PLA2G1B;CCL5
607	antigen processing and presentation of exogenous peptide antigen (GO:0002478)	3/171	0.2446846	1.0000000	0	0	1.7543860	2.4697984	CD207;HLA-DOA;HLA-DQB2
608	regulation of mononuclear cell proliferation (GO:0032944)	3/171	0.2446846	1.0000000	0	0	1.7543860	2.4697984	CCL5;SFTPD;SCGB1A1
609	negative regulation of cytokine biosynthetic process (GO:0042036)	1/28	0.2454244	1.0000000	0	0	3.5714286	5.0170219	SFTPD
610	response to fluid shear stress (GO:0034405)	1/28	0.2454244	1.0000000	0	0	3.5714286	5.0170219	GJA1
611	positive regulation of BMP signaling pathway (GO:0030513)	1/28	0.2454244	1.0000000	0	0	3.5714286	5.0170219	GPC3
612	dopamine metabolic process (GO:0042417)	1/28	0.2454244	1.0000000	0	0	3.5714286	5.0170219	DDC
613	tissue regeneration (GO:0042246)	1/28	0.2454244	1.0000000	0	0	3.5714286	5.0170219	GJA1
614	antimicrobial humoral response (GO:0019730)	1/28	0.2454244	1.0000000	0	0	3.5714286	5.0170219	PLA2G1B
615	rhythmic process (GO:0048511)	4/252	0.2455112	1.0000000	0	0	1.5873016	2.2292267	ROBO2;KISS1;DDC;HLF
616	regulation of lymphocyte mediated immunity (GO:0002706)	2/95	0.2457050	1.0000000	0	0	2.1052632	2.9549968	KLRK1;CRTAM
617	metal ion homeostasis (GO:0055065)	6/422	0.2480835	1.0000000	0	0	1.4218009	1.9819764	KISS1;CD52;GJA1;CCL5;KCNK3;ABCG2
618	antigen processing and presentation of peptide or polysaccharide antigen via MHC class II (GO:0002504)	2/96	0.2494068	1.0000000	0	0	2.0833333	2.8930625	HLA-DOA;HLA-DQB2
619	antigen processing and presentation of exogenous antigen (GO:0019884)	3/173	0.2500255	1.0000000	0	0	1.7341040	2.4038017	CD207;HLA-DOA;HLA-DQB2
620	cellular response to heat (GO:0034605)	1/29	0.2529808	1.0000000	0	0	3.4482759	4.7394545	STAC
621	central nervous system neuron axonogenesis (GO:0021955)	1/29	0.2529808	1.0000000	0	0	3.4482759	4.7394545	DCX
622	response to pH (GO:0009268)	1/29	0.2529808	1.0000000	0	0	3.4482759	4.7394545	GJA1
623	lipopolysaccharide-mediated signaling pathway (GO:0031663)	1/29	0.2529808	1.0000000	0	0	3.4482759	4.7394545	CCL5
624	regulation of defense response to virus by virus (GO:0050690)	1/29	0.2529808	1.0000000	0	0	3.4482759	4.7394545	CD8B
625	positive regulation of cardiac muscle tissue development (GO:0055025)	1/29	0.2529808	1.0000000	0	0	3.4482759	4.7394545	FGF9
626	regulation of protein activation cascade (GO:2000257)	1/29	0.2529808	1.0000000	0	0	3.4482759	4.7394545	PROS1
627	cardiac muscle cell action potential involved in contraction (GO:0086002)	1/29	0.2529808	1.0000000	0	0	3.4482759	4.7394545	GJA1
628	regulation of fibroblast growth factor receptor signaling pathway (GO:0040036)	1/29	0.2529808	1.0000000	0	0	3.4482759	4.7394545	HHIP
629	cerebral cortex cell migration (GO:0021795)	1/29	0.2529808	1.0000000	0	0	3.4482759	4.7394545	CX3CR1
630	NAD metabolic process (GO:0019674)	1/29	0.2529808	1.0000000	0	0	3.4482759	4.7394545	QPRT
631	terpenoid metabolic process (GO:0006721)	2/97	0.2531103	1.0000000	0	0	2.0618557	2.8328453	OPN1SW;GPC3
632	alcohol metabolic process (GO:0006066)	5/340	0.2542695	1.0000000	0	0	1.4705882	2.0137658	CH25H;ADH1C;ADH1B;PLA2G1B;LEPR
633	detection of external stimulus (GO:0009581)	3/175	0.2553840	1.0000000	0	0	1.7142857	2.3399779	OPN1SW;CNGA1;GPC3
634	neuron projection morphogenesis (GO:0048812)	3/175	0.2553840	1.0000000	0	0	1.7142857	2.3399779	GPM6A;GJA1;DCX
635	osteoblast differentiation (GO:0001649)	2/98	0.2568151	1.0000000	0	0	2.0408163	2.7742832	GJA1;FGF9
636	regulation of leukocyte proliferation (GO:0070663)	3/176	0.2580694	1.0000000	0	0	1.7045455	2.3088527	CCL5;SFTPD;SCGB1A1
637	regulation of epithelial cell proliferation (GO:0050678)	4/258	0.2585787	1.0000000	0	0	1.5503876	2.0969850	KRT4;FGF9;FLT4;GPC3
638	lens development in camera-type eye (GO:0002088)	1/30	0.2604618	1.0000000	0	0	3.3333333	4.4843302	GJA1
639	hair follicle morphogenesis (GO:0031069)	1/30	0.2604618	1.0000000	0	0	3.3333333	4.4843302	TGM3
640	endochondral ossification (GO:0001958)	1/30	0.2604618	1.0000000	0	0	3.3333333	4.4843302	FGF18
641	positive regulation of multicellular organismal metabolic process (GO:0044253)	1/30	0.2604618	1.0000000	0	0	3.3333333	4.4843302	MC4R
642	embryonic hindlimb morphogenesis (GO:0035116)	1/30	0.2604618	1.0000000	0	0	3.3333333	4.4843302	GPC3
643	central nervous system neuron development (GO:0021954)	1/30	0.2604618	1.0000000	0	0	3.3333333	4.4843302	ROBO2
644	cardiac muscle cell action potential (GO:0086001)	1/30	0.2604618	1.0000000	0	0	3.3333333	4.4843302	GJA1
645	positive regulation of glucose import (GO:0046326)	1/30	0.2604618	1.0000000	0	0	3.3333333	4.4843302	GPC3
646	regulation of rhodopsin mediated signaling pathway (GO:0022400)	1/30	0.2604618	1.0000000	0	0	3.3333333	4.4843302	CNGA1
647	axon extension (GO:0048675)	1/30	0.2604618	1.0000000	0	0	3.3333333	4.4843302	DCX
648	regulation of granulocyte chemotaxis (GO:0071622)	1/30	0.2604618	1.0000000	0	0	3.3333333	4.4843302	CCL5
649	replacement ossification (GO:0036075)	1/30	0.2604618	1.0000000	0	0	3.3333333	4.4843302	FGF18
650	neurotransmitter transport (GO:0006836)	2/99	0.2605209	1.0000000	0	0	2.0202020	2.7173172	SLC5A7;SLC6A13
651	single organism cell adhesion (GO:0098602)	4/259	0.2607703	1.0000000	0	0	1.5444015	2.0758538	CCL5;ANXA9;JAM2;CDH7
652	detection of abiotic stimulus (GO:0009582)	3/178	0.2634516	1.0000000	0	0	1.6853933	2.2481220	OPN1SW;CNGA1;GPC3
653	cell-matrix adhesion (GO:0007160)	2/100	0.2642273	1.0000000	0	0	2.0000000	2.6618910	ECM2;PPFIA2
654	unsaturated fatty acid metabolic process (GO:0033559)	2/100	0.2642273	1.0000000	0	0	2.0000000	2.6618910	PLA2G1B;ALOX12
655	defense response to bacterium (GO:0042742)	3/179	0.2661481	1.0000000	0	0	1.6759777	2.2184959	PLA2G1B;SFTPD;BPI
656	positive regulation of leukocyte activation (GO:0002696)	4/262	0.2673668	1.0000000	0	0	1.5267176	2.0139444	KLRK1;CCL5;TRAC;HLA-DQB2
657	regulation of response to wounding (GO:1903034)	5/347	0.2674975	1.0000000	0	0	1.4409222	1.9000649	PROS1;CCL5;SCGB1A1;ALOX12;HOPX
658	bicarbonate transport (GO:0015701)	1/31	0.2678683	1.0000000	0	0	3.2258065	4.2492255	SLC4A10
659	phosphatidic acid biosynthetic process (GO:0006654)	1/31	0.2678683	1.0000000	0	0	3.2258065	4.2492255	PLA2G1B
660	positive regulation of blood pressure (GO:0045777)	1/31	0.2678683	1.0000000	0	0	3.2258065	4.2492255	OR51E2
661	cellular response to alkaloid (GO:0071312)	1/31	0.2678683	1.0000000	0	0	3.2258065	4.2492255	DDC
662	regulation of endothelial cell apoptotic process (GO:2000351)	1/31	0.2678683	1.0000000	0	0	3.2258065	4.2492255	RAMP2
663	regulation of meiosis (GO:0040020)	1/31	0.2678683	1.0000000	0	0	3.2258065	4.2492255	DMRT1
664	regulation of Rho protein signal transduction (GO:0035023)	1/31	0.2678683	1.0000000	0	0	3.2258065	4.2492255	DLC1
665	modification by host of symbiont morphology or physiology (GO:0051851)	1/31	0.2678683	1.0000000	0	0	3.2258065	4.2492255	CCL5
666	phenol-containing compound biosynthetic process (GO:0046189)	1/31	0.2678683	1.0000000	0	0	3.2258065	4.2492255	DDC
667	regulation of smooth muscle cell migration (GO:0014910)	1/31	0.2678683	1.0000000	0	0	3.2258065	4.2492255	CCL5
668	negative regulation of interleukin-6 production (GO:0032715)	1/31	0.2678683	1.0000000	0	0	3.2258065	4.2492255	BPI
669	protein kinase B signaling (GO:0043491)	1/31	0.2678683	1.0000000	0	0	3.2258065	4.2492255	CCL5
670	phosphatidic acid metabolic process (GO:0046473)	1/31	0.2678683	1.0000000	0	0	3.2258065	4.2492255	PLA2G1B
671	regulation of collagen metabolic process (GO:0010712)	1/31	0.2678683	1.0000000	0	0	3.2258065	4.2492255	MFAP4
672	peptide cross-linking (GO:0018149)	1/31	0.2678683	1.0000000	0	0	3.2258065	4.2492255	TGM3
673	positive chemotaxis (GO:0050918)	1/31	0.2678683	1.0000000	0	0	3.2258065	4.2492255	CCL5
674	tube morphogenesis (GO:0035239)	2/101	0.2679339	1.0000000	0	0	1.9801980	2.6079506	GJA1;GPC3
675	taxis (GO:0042330)	4/263	0.2695726	1.0000000	0	0	1.5209125	1.9937909	CX3CR1;PLA2G1B;CCL5;SFTPD
676	chemotaxis (GO:0006935)	4/263	0.2695726	1.0000000	0	0	1.5209125	1.9937909	CX3CR1;PLA2G1B;CCL5;SFTPD
677	negative regulation of lymphocyte activation (GO:0051250)	2/102	0.2716403	1.0000000	0	0	1.9607843	2.5554444	SFTPD;SCGB1A1
678	multi-organism localization (GO:1902579)	1/32	0.2752010	1.0000000	0	0	3.1250000	4.0320428	IFIT1
679	negative regulation of striated muscle tissue development (GO:0045843)	1/32	0.2752010	1.0000000	0	0	3.1250000	4.0320428	GJA1
680	positive regulation of protein tyrosine kinase activity (GO:0061098)	1/32	0.2752010	1.0000000	0	0	3.1250000	4.0320428	CCL5
681	intracellular transport of virus (GO:0075733)	1/32	0.2752010	1.0000000	0	0	3.1250000	4.0320428	IFIT1
682	multi-organism transport (GO:0044766)	1/32	0.2752010	1.0000000	0	0	3.1250000	4.0320428	IFIT1
683	multi-organism intracellular transport (GO:1902583)	1/32	0.2752010	1.0000000	0	0	3.1250000	4.0320428	IFIT1
684	regulation of potassium ion transmembrane transport (GO:1901379)	1/32	0.2752010	1.0000000	0	0	3.1250000	4.0320428	KCNJ1
685	multicellular organismal water homeostasis (GO:0050891)	1/32	0.2752010	1.0000000	0	0	3.1250000	4.0320428	ALOX12
686	negative regulation of cytokine-mediated signaling pathway (GO:0001960)	1/32	0.2752010	1.0000000	0	0	3.1250000	4.0320428	CCL5
687	transport of virus (GO:0046794)	1/32	0.2752010	1.0000000	0	0	3.1250000	4.0320428	IFIT1
688	negative regulation of cAMP biosynthetic process (GO:0030818)	1/32	0.2752010	1.0000000	0	0	3.1250000	4.0320428	GABBR2
689	superoxide metabolic process (GO:0006801)	1/32	0.2752010	1.0000000	0	0	3.1250000	4.0320428	ALOX12
690	response to pain (GO:0048265)	1/32	0.2752010	1.0000000	0	0	3.1250000	4.0320428	GRIK1
691	regulation of synaptic transmission, GABAergic (GO:0032228)	1/32	0.2752010	1.0000000	0	0	3.1250000	4.0320428	GRIK1
692	regulation of lymphocyte migration (GO:2000401)	1/32	0.2752010	1.0000000	0	0	3.1250000	4.0320428	CCL5
693	regulation of T cell apoptotic process (GO:0070232)	1/32	0.2752010	1.0000000	0	0	3.1250000	4.0320428	CCL5
694	regulation of transforming growth factor beta receptor signaling pathway (GO:0017015)	2/103	0.2753461	1.0000000	0	0	1.9417476	2.5043233	PEG10;FBN1
695	cellular response to fibroblast growth factor stimulus (GO:0044344)	3/183	0.2769660	1.0000000	0	0	1.6393443	2.1046893	FGF9;CCL5;FGF18
696	antigen processing and presentation of peptide antigen (GO:0048002)	3/185	0.2823919	1.0000000	0	0	1.6216216	2.0504748	CD207;HLA-DOA;HLA-DQB2
697	negative regulation of cytokine production (GO:0001818)	3/185	0.2823919	1.0000000	0	0	1.6216216	2.0504748	SFTPD;SCGB1A1;BPI
698	peptide hormone processing (GO:0016486)	1/33	0.2824605	1.0000000	0	0	3.0303030	3.8309588	SCG5
699	positive regulation of reproductive process (GO:2000243)	1/33	0.2824605	1.0000000	0	0	3.0303030	3.8309588	DMRT1
700	histone deacetylation (GO:0016575)	1/33	0.2824605	1.0000000	0	0	3.0303030	3.8309588	HOPX
701	interaction with symbiont (GO:0051702)	1/33	0.2824605	1.0000000	0	0	3.0303030	3.8309588	CCL5
702	regulation of bone resorption (GO:0045124)	1/33	0.2824605	1.0000000	0	0	3.0303030	3.8309588	MC4R
703	response to progesterone (GO:0032570)	1/33	0.2824605	1.0000000	0	0	3.0303030	3.8309588	RAMP2
704	rhodopsin mediated signaling pathway (GO:0016056)	1/33	0.2824605	1.0000000	0	0	3.0303030	3.8309588	CNGA1
705	negative regulation of cyclic nucleotide biosynthetic process (GO:0030803)	1/33	0.2824605	1.0000000	0	0	3.0303030	3.8309588	GABBR2
706	negative regulation of muscle tissue development (GO:1901862)	1/33	0.2824605	1.0000000	0	0	3.0303030	3.8309588	GJA1
707	positive regulation of ion transport (GO:0043270)	3/186	0.2851085	1.0000000	0	0	1.6129032	2.0240089	PLA2G1B;CCL5;GRIK1
708	immune response-regulating cell surface receptor signaling pathway (GO:0002768)	6/444	0.2852710	1.0000000	0	0	1.3513514	1.6950213	IGHG4;FGF9;TRAC;FGF18;SKAP1;HLA-DQB2
709	skeletal system morphogenesis (GO:0048705)	2/106	0.2864567	1.0000000	0	0	1.8867925	2.3588071	HHIP;TBX4
710	response to transition metal nanoparticle (GO:1990267)	2/106	0.2864567	1.0000000	0	0	1.8867925	2.3588071	KCNK3;ABCG2
711	brain development (GO:0007420)	3/187	0.2878273	1.0000000	0	0	1.6042781	1.9979593	ROBO2;DCX;KCNK3
712	organic acid biosynthetic process (GO:0016053)	4/272	0.2895615	1.0000000	0	0	1.4705882	1.8226289	CH25H;PLA2G1B;PADI3;ALOX12
713	carboxylic acid biosynthetic process (GO:0046394)	4/272	0.2895615	1.0000000	0	0	1.4705882	1.8226289	CH25H;PLA2G1B;PADI3;ALOX12
714	positive regulation of defense response (GO:0031349)	4/272	0.2895615	1.0000000	0	0	1.4705882	1.8226289	GJA1;KLRK1;CCL5;CRTAM
715	positive regulation of cell activation (GO:0050867)	4/272	0.2895615	1.0000000	0	0	1.4705882	1.8226289	KLRK1;CCL5;TRAC;HLA-DQB2
716	dendrite morphogenesis (GO:0048813)	1/34	0.2896478	1.0000000	0	0	2.9411765	3.6443812	DCX
717	negative regulation of muscle organ development (GO:0048635)	1/34	0.2896478	1.0000000	0	0	2.9411765	3.6443812	GJA1
718	negative regulation of reproductive process (GO:2000242)	1/34	0.2896478	1.0000000	0	0	2.9411765	3.6443812	NPPC
719	response to cocaine (GO:0042220)	1/34	0.2896478	1.0000000	0	0	2.9411765	3.6443812	SNCG
720	negative regulation of tumor necrosis factor production (GO:0032720)	1/34	0.2896478	1.0000000	0	0	2.9411765	3.6443812	BPI
721	phosphatidylglycerol metabolic process (GO:0046471)	1/34	0.2896478	1.0000000	0	0	2.9411765	3.6443812	PLA2G1B
722	negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway (GO:0090101)	2/107	0.2901569	1.0000000	0	0	1.8691589	2.3127732	PEG10;FBN1
723	cholesterol metabolic process (GO:0008203)	2/107	0.2901569	1.0000000	0	0	1.8691589	2.3127732	CH25H;LEPR
724	positive regulation of behavior (GO:0048520)	2/107	0.2901569	1.0000000	0	0	1.8691589	2.3127732	GJA1;CCL5
725	positive regulation of growth (GO:0045927)	3/189	0.2932710	1.0000000	0	0	1.5873016	1.9470766	FGF9;ALOX12;HOPX
726	inorganic anion transmembrane transport (GO:0098661)	2/108	0.2938547	1.0000000	0	0	1.8518519	2.2679071	GABRD;CLCA4
727	positive regulation of innate immune response (GO:0045089)	3/190	0.2959955	1.0000000	0	0	1.5789474	1.9222277	KLRK1;CCL5;CRTAM
728	dendrite development (GO:0016358)	1/35	0.2967634	1.0000000	0	0	2.8571429	3.4709146	FEZF2
729	positive regulation of glucose transport (GO:0010828)	1/35	0.2967634	1.0000000	0	0	2.8571429	3.4709146	GPC3
730	insulin secretion (GO:0030073)	1/35	0.2967634	1.0000000	0	0	2.8571429	3.4709146	MC4R
731	regulation of antigen receptor-mediated signaling pathway (GO:0050854)	1/35	0.2967634	1.0000000	0	0	2.8571429	3.4709146	UBASH3A
732	negative regulation of purine nucleotide biosynthetic process (GO:1900372)	1/35	0.2967634	1.0000000	0	0	2.8571429	3.4709146	GABBR2
733	myeloid cell activation involved in immune response (GO:0002275)	1/35	0.2967634	1.0000000	0	0	2.8571429	3.4709146	CX3CR1
734	alditol phosphate metabolic process (GO:0052646)	1/35	0.2967634	1.0000000	0	0	2.8571429	3.4709146	PLA2G1B
735	regulation of filopodium assembly (GO:0051489)	1/35	0.2967634	1.0000000	0	0	2.8571429	3.4709146	GPM6A
736	metanephros development (GO:0001656)	1/35	0.2967634	1.0000000	0	0	2.8571429	3.4709146	ROBO2
737	negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)	1/35	0.2967634	1.0000000	0	0	2.8571429	3.4709146	BPI
738	embryonic skeletal system development (GO:0048706)	1/35	0.2967634	1.0000000	0	0	2.8571429	3.4709146	FGF9
739	neuron projection extension (GO:1990138)	1/35	0.2967634	1.0000000	0	0	2.8571429	3.4709146	DCX
740	positive regulation of phagocytosis (GO:0050766)	1/35	0.2967634	1.0000000	0	0	2.8571429	3.4709146	SFTPD
741	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001240)	1/35	0.2967634	1.0000000	0	0	2.8571429	3.4709146	CX3CR1
742	negative regulation of signal transduction in absence of ligand (GO:1901099)	1/35	0.2967634	1.0000000	0	0	2.8571429	3.4709146	CX3CR1
743	cAMP metabolic process (GO:0046058)	1/35	0.2967634	1.0000000	0	0	2.8571429	3.4709146	RAMP2
744	negative regulation of nucleotide biosynthetic process (GO:0030809)	1/35	0.2967634	1.0000000	0	0	2.8571429	3.4709146	GABBR2
745	negative regulation of ERK1 and ERK2 cascade (GO:0070373)	1/35	0.2967634	1.0000000	0	0	2.8571429	3.4709146	DUSP26
746	cellular chemical homeostasis (GO:0055082)	6/452	0.2990968	1.0000000	0	0	1.3274336	1.6021964	KISS1;CD52;GJA1;CCL5;KCNK3;ABCG2
747	negative regulation of epithelial cell proliferation (GO:0050680)	2/110	0.3012423	1.0000000	0	0	1.8181818	2.1815278	KRT4;GPC3
748	cellular response to lipopolysaccharide (GO:0071222)	2/110	0.3012423	1.0000000	0	0	1.8181818	2.1815278	CX3CR1;CCL5
749	regulation of gluconeogenesis (GO:0006111)	1/36	0.3038081	1.0000000	0	0	2.7777778	3.3093308	LEPR
750	regulation of cell adhesion mediated by integrin (GO:0033628)	1/36	0.3038081	1.0000000	0	0	2.7777778	3.3093308	CCL5
751	negative regulation of response to cytokine stimulus (GO:0060761)	1/36	0.3038081	1.0000000	0	0	2.7777778	3.3093308	CCL5
752	regulation of catecholamine secretion (GO:0050433)	1/36	0.3038081	1.0000000	0	0	2.7777778	3.3093308	SNCG
753	negative regulation of cellular carbohydrate metabolic process (GO:0010677)	1/36	0.3038081	1.0000000	0	0	2.7777778	3.3093308	LEPR
754	placenta development (GO:0001890)	1/36	0.3038081	1.0000000	0	0	2.7777778	3.3093308	PEG10
755	negative regulation of cAMP metabolic process (GO:0030815)	1/36	0.3038081	1.0000000	0	0	2.7777778	3.3093308	GABBR2
756	chromosome organization involved in meiosis (GO:0070192)	1/36	0.3038081	1.0000000	0	0	2.7777778	3.3093308	MEIOB
757	positive regulation of organ growth (GO:0046622)	1/36	0.3038081	1.0000000	0	0	2.7777778	3.3093308	FGF9
758	protein deacetylation (GO:0006476)	1/36	0.3038081	1.0000000	0	0	2.7777778	3.3093308	HOPX
759	response to alkaloid (GO:0043279)	2/111	0.3049314	1.0000000	0	0	1.8018018	2.1399429	DDC;SNCG
760	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process (GO:0043280)	2/111	0.3049314	1.0000000	0	0	1.8018018	2.1399429	DLC1;ALOX12
761	synapse organization (GO:0050808)	2/111	0.3049314	1.0000000	0	0	1.8018018	2.1399429	GPM6A;SNCG
762	positive regulation of cell migration (GO:0030335)	4/280	0.3074995	1.0000000	0	0	1.4285714	1.6846883	FLT4;CCL5;ALOX12;GPR124
763	regulation of striated muscle tissue development (GO:0016202)	2/112	0.3086171	1.0000000	0	0	1.7857143	2.0993823	GJA1;FGF9
764	cellular response to insulin stimulus (GO:0032869)	3/195	0.3096393	1.0000000	0	0	1.5384615	1.8036111	FGF9;PLA2G1B;FGF18
765	positive regulation of mesenchymal cell proliferation (GO:0002053)	1/37	0.3107825	1.0000000	0	0	2.7027027	3.1585455	FGF9
766	anterior/posterior axis specification (GO:0009948)	1/37	0.3107825	1.0000000	0	0	2.7027027	3.1585455	GPC3
767	positive regulation of calcium ion transport into cytosol (GO:0010524)	1/37	0.3107825	1.0000000	0	0	2.7027027	3.1585455	PLA2G1B
768	negative regulation of cyclic nucleotide metabolic process (GO:0030800)	1/37	0.3107825	1.0000000	0	0	2.7027027	3.1585455	GABBR2
769	regulation of muscle tissue development (GO:1901861)	2/113	0.3122988	1.0000000	0	0	1.7699115	2.0598136	GJA1;FGF9
770	regulation of muscle organ development (GO:0048634)	2/114	0.3159765	1.0000000	0	0	1.7543860	2.0212059	GJA1;FGF9
771	isoprenoid metabolic process (GO:0006720)	2/114	0.3159765	1.0000000	0	0	1.7543860	2.0212059	OPN1SW;GPC3
772	cellular response to hormone stimulus (GO:0032870)	6/462	0.3165564	1.0000000	0	0	1.2987013	1.4938364	ROBO2;RAMP2;FGF9;PLA2G1B;FGF18;OR51E2
773	negative regulation of Ras protein signal transduction (GO:0046580)	1/38	0.3176875	1.0000000	0	0	2.6315789	3.0175977	DLC1
774	anion homeostasis (GO:0055081)	1/38	0.3176875	1.0000000	0	0	2.6315789	3.0175977	FABP3
775	regulation of muscle cell apoptotic process (GO:0010660)	1/38	0.3176875	1.0000000	0	0	2.6315789	3.0175977	ALOX12
776	water homeostasis (GO:0030104)	1/38	0.3176875	1.0000000	0	0	2.6315789	3.0175977	ALOX12
777	hindlimb morphogenesis (GO:0035137)	1/38	0.3176875	1.0000000	0	0	2.6315789	3.0175977	GPC3
778	leukocyte activation (GO:0045321)	5/373	0.3177926	1.0000000	0	0	1.3404826	1.5366707	CX3CR1;KLRK1;CD8B;CCL5;CRTAM
779	negative regulation of cell adhesion (GO:0007162)	2/115	0.3196498	1.0000000	0	0	1.7391304	1.9835291	ALOX12;JAM2
780	positive regulation of ERK1 and ERK2 cascade (GO:0070374)	2/115	0.3196498	1.0000000	0	0	1.7391304	1.9835291	FLT4;FGF18
781	positive regulation of cell motility (GO:2000147)	4/287	0.3232894	1.0000000	0	0	1.3937282	1.5738081	FLT4;CCL5;ALOX12;GPR124
782	cellular response to molecule of bacterial origin (GO:0071219)	2/116	0.3233184	1.0000000	0	0	1.7241379	1.9467545	CX3CR1;CCL5
783	ossification (GO:0001503)	2/116	0.3233184	1.0000000	0	0	1.7241379	1.9467545	NPPC;FGF18
784	social behavior (GO:0035176)	1/39	0.3245236	1.0000000	0	0	2.5641026	2.8856335	GRID1
785	heart morphogenesis (GO:0003007)	1/39	0.3245236	1.0000000	0	0	2.5641026	2.8856335	DLC1
786	positive regulation of cell-cell adhesion (GO:0022409)	1/39	0.3245236	1.0000000	0	0	2.5641026	2.8856335	CCL5
787	bone mineralization (GO:0030282)	1/39	0.3245236	1.0000000	0	0	2.5641026	2.8856335	GPC3
788	bile acid metabolic process (GO:0008206)	1/39	0.3245236	1.0000000	0	0	2.5641026	2.8856335	CH25H
789	positive regulation of striated muscle cell differentiation (GO:0051155)	1/39	0.3245236	1.0000000	0	0	2.5641026	2.8856335	HOPX
790	intraspecies interaction between organisms (GO:0051703)	1/39	0.3245236	1.0000000	0	0	2.5641026	2.8856335	GRID1
791	embryo implantation (GO:0007566)	1/39	0.3245236	1.0000000	0	0	2.5641026	2.8856335	SCGB1A1
792	tight junction assembly (GO:0070830)	1/39	0.3245236	1.0000000	0	0	2.5641026	2.8856335	RAMP2
793	protein deacylation (GO:0035601)	1/39	0.3245236	1.0000000	0	0	2.5641026	2.8856335	HOPX
794	negative regulation of small GTPase mediated signal transduction (GO:0051058)	1/39	0.3245236	1.0000000	0	0	2.5641026	2.8856335	DLC1
795	sterol biosynthetic process (GO:0016126)	1/39	0.3245236	1.0000000	0	0	2.5641026	2.8856335	CH25H
796	response to bacterium (GO:0009617)	3/201	0.3260385	1.0000000	0	0	1.4925373	1.6727460	PLA2G1B;SFTPD;BPI
797	secondary metabolic process (GO:0019748)	1/40	0.3312915	1.0000000	0	0	2.5000000	2.7618913	DDC
798	negative regulation of BMP signaling pathway (GO:0030514)	1/40	0.3312915	1.0000000	0	0	2.5000000	2.7618913	FBN1
799	ureteric bud development (GO:0001657)	1/40	0.3312915	1.0000000	0	0	2.5000000	2.7618913	ROBO2
800	cellular response to cytokine stimulus (GO:0071345)	6/471	0.3324065	1.0000000	0	0	1.2738854	1.4030529	CX3CR1;CCL5;LEPR;IFIT1;HLA-DQB2;OASL
801	negative regulation of locomotion (GO:0040013)	3/204	0.3342400	1.0000000	0	0	1.4705882	1.6116117	ROBO2;CX3CR1;DLC1
802	sterol metabolic process (GO:0016125)	2/119	0.3342935	1.0000000	0	0	1.6806723	1.8415730	CH25H;LEPR
803	positive regulation of cysteine-type endopeptidase activity (GO:2001056)	2/119	0.3342935	1.0000000	0	0	1.6806723	1.8415730	DLC1;ALOX12
804	regulation of leukocyte mediated immunity (GO:0002703)	2/120	0.3379407	1.0000000	0	0	1.6666667	1.8081412	KLRK1;CRTAM
805	positive regulation of cell division (GO:0051781)	2/120	0.3379407	1.0000000	0	0	1.6666667	1.8081412	FGF9;DMRT1
806	macromolecule deacylation (GO:0098732)	1/41	0.3379920	1.0000000	0	0	2.4390244	2.6456903	HOPX
807	negative regulation of cell-cell adhesion (GO:0022408)	1/41	0.3379920	1.0000000	0	0	2.4390244	2.6456903	ALOX12
808	cell-substrate junction assembly (GO:0007044)	1/41	0.3379920	1.0000000	0	0	2.4390244	2.6456903	DLC1
809	response to exogenous dsRNA (GO:0043330)	1/41	0.3379920	1.0000000	0	0	2.4390244	2.6456903	IFIT1
810	T cell proliferation (GO:0042098)	1/41	0.3379920	1.0000000	0	0	2.4390244	2.6456903	CRTAM
811	negative regulation of leukocyte apoptotic process (GO:2000107)	1/41	0.3379920	1.0000000	0	0	2.4390244	2.6456903	CCL5
812	regulation of synapse assembly (GO:0051963)	1/41	0.3379920	1.0000000	0	0	2.4390244	2.6456903	ROBO2
813	oligosaccharide metabolic process (GO:0009311)	1/41	0.3379920	1.0000000	0	0	2.4390244	2.6456903	ST6GAL2
814	regulation of chondrocyte differentiation (GO:0032330)	1/41	0.3379920	1.0000000	0	0	2.4390244	2.6456903	FGF18
815	response to zinc ion (GO:0010043)	1/41	0.3379920	1.0000000	0	0	2.4390244	2.6456903	KCNK3
816	positive regulation of wound healing (GO:0090303)	1/41	0.3379920	1.0000000	0	0	2.4390244	2.6456903	HOPX
817	multi-multicellular organism process (GO:0044706)	2/121	0.3415820	1.0000000	0	0	1.6528926	1.7754835	RAMP2;SCGB1A1
818	morphogenesis of an epithelium (GO:0002009)	4/296	0.3436708	1.0000000	0	0	1.3513514	1.4433392	GJA1;HHIP;GPC3;TBX4
819	positive regulation of cellular component movement (GO:0051272)	4/296	0.3436708	1.0000000	0	0	1.3513514	1.4433392	FLT4;CCL5;ALOX12;GPR124
820	positive regulation of mitosis (GO:0045840)	1/42	0.3446257	1.0000000	0	0	2.3809524	2.5364201	DMRT1
821	nucleotide biosynthetic process (GO:0009165)	3/208	0.3451691	1.0000000	0	0	1.4423077	1.5342129	NPPC;RAMP2;QPRT
822	regulation of lipase activity (GO:0060191)	2/122	0.3452170	1.0000000	0	0	1.6393443	1.7435771	PLA2G1B;CCL5
823	nucleoside phosphate biosynthetic process (GO:1901293)	3/209	0.3478993	1.0000000	0	0	1.4354067	1.5155629	NPPC;RAMP2;QPRT
824	positive regulation of multi-organism process (GO:0043902)	2/123	0.3488456	1.0000000	0	0	1.6260163	1.7123999	CCL5;IFIT1
825	cell killing (GO:0001906)	1/43	0.3511932	1.0000000	0	0	2.3255814	2.4335320	CRTAM
826	catechol-containing compound metabolic process (GO:0009712)	1/43	0.3511932	1.0000000	0	0	2.3255814	2.4335320	DDC
827	regulation of mesenchymal cell proliferation (GO:0010464)	1/43	0.3511932	1.0000000	0	0	2.3255814	2.4335320	FGF9
828	receptor internalization (GO:0031623)	1/43	0.3511932	1.0000000	0	0	2.3255814	2.4335320	RAMP2
829	negative regulation of carbohydrate metabolic process (GO:0045912)	1/43	0.3511932	1.0000000	0	0	2.3255814	2.4335320	LEPR
830	catecholamine metabolic process (GO:0006584)	1/43	0.3511932	1.0000000	0	0	2.3255814	2.4335320	DDC
831	regulation of organic acid transport (GO:0032890)	1/43	0.3511932	1.0000000	0	0	2.3255814	2.4335320	GRIK1
832	carbohydrate derivative transport (GO:1901264)	1/43	0.3511932	1.0000000	0	0	2.3255814	2.4335320	GJA1
833	regulation of cytokine production (GO:0001817)	6/482	0.3519100	1.0000000	0	0	1.2448133	1.3000578	FLT4;SFTPD;CRTAM;SCGB1A1;BPI;UBASH3A
834	cellular biogenic amine metabolic process (GO:0006576)	2/125	0.3560824	1.0000000	0	0	1.6000000	1.6521490	DDC;PLA2G1B
835	cellular amine metabolic process (GO:0044106)	2/125	0.3560824	1.0000000	0	0	1.6000000	1.6521490	DDC;PLA2G1B
836	vasculature development (GO:0001944)	1/44	0.3576952	1.0000000	0	0	2.2727273	2.3365317	FLT4
837	neutrophil chemotaxis (GO:0030593)	1/44	0.3576952	1.0000000	0	0	2.2727273	2.3365317	PLA2G1B
838	branching involved in ureteric bud morphogenesis (GO:0001658)	1/44	0.3576952	1.0000000	0	0	2.2727273	2.3365317	GPC3
839	mesonephric tubule development (GO:0072164)	1/44	0.3576952	1.0000000	0	0	2.2727273	2.3365317	ROBO2
840	epithelial cell differentiation (GO:0030855)	4/303	0.3595502	1.0000000	0	0	1.3201320	1.3503648	SCUBE1;KRT4;DMRT1;TGM3
841	purine ribonucleotide biosynthetic process (GO:0009152)	2/126	0.3596902	1.0000000	0	0	1.5873016	1.6230353	NPPC;RAMP2
842	negative regulation of Wnt signaling pathway (GO:0030178)	2/126	0.3596902	1.0000000	0	0	1.5873016	1.6230353	FGF9;GPC3
843	cellular response to radiation (GO:0071478)	2/126	0.3596902	1.0000000	0	0	1.5873016	1.6230353	MFAP4;CNGA1
844	regulation of Wnt signaling pathway (GO:0030111)	3/214	0.3615322	1.0000000	0	0	1.4018692	1.4262677	FGF9;GPC3;LGR5
845	positive regulation of locomotion (GO:0040017)	4/304	0.3618189	1.0000000	0	0	1.3157895	1.3376467	FLT4;CCL5;ALOX12;GPR124
846	mesonephric epithelium development (GO:0072163)	1/45	0.3641324	1.0000000	0	0	2.2222222	2.2449725	ROBO2
847	regulation of interleukin-2 production (GO:0032663)	1/45	0.3641324	1.0000000	0	0	2.2222222	2.2449725	SFTPD
848	regulation of humoral immune response (GO:0002920)	1/45	0.3641324	1.0000000	0	0	2.2222222	2.2449725	PROS1
849	substantia nigra development (GO:0021762)	1/45	0.3641324	1.0000000	0	0	2.2222222	2.2449725	FGF9
850	cellular response to interleukin-1 (GO:0071347)	1/45	0.3641324	1.0000000	0	0	2.2222222	2.2449725	CCL5
851	excretion (GO:0007588)	1/45	0.3641324	1.0000000	0	0	2.2222222	2.2449725	KCNJ1
852	neutrophil migration (GO:1990266)	1/45	0.3641324	1.0000000	0	0	2.2222222	2.2449725	PLA2G1B
853	calcium ion transport (GO:0006816)	3/215	0.3642542	1.0000000	0	0	1.3953488	1.4091675	GPM6A;RAMP2;CCL5
854	positive regulation of endopeptidase activity (GO:0010950)	2/128	0.3668834	1.0000000	0	0	1.5625000	1.5667361	DLC1;ALOX12
855	regulation of protein binding (GO:0043393)	2/128	0.3668834	1.0000000	0	0	1.5625000	1.5667361	IFIT1;HOPX
856	tissue homeostasis (GO:0001894)	2/129	0.3704685	1.0000000	0	0	1.5503876	1.5395146	SFTPD;KCNJ1
857	negative regulation of developmental growth (GO:0048640)	1/46	0.3705054	1.0000000	0	0	2.1739130	2.1584503	GJA1
858	positive regulation of tyrosine phosphorylation of STAT protein (GO:0042531)	1/46	0.3705054	1.0000000	0	0	2.1739130	2.1584503	CCL5
859	inner ear development (GO:0048839)	1/46	0.3705054	1.0000000	0	0	2.1739130	2.1584503	LGR5
860	leukocyte cell-cell adhesion (GO:0007159)	1/46	0.3705054	1.0000000	0	0	2.1739130	2.1584503	CCL5
861	respiratory gaseous exchange (GO:0007585)	1/46	0.3705054	1.0000000	0	0	2.1739130	2.1584503	SFTPD
862	regulation of binding (GO:0051098)	3/218	0.3724090	1.0000000	0	0	1.3761468	1.3593063	IFIT1;HOPX;RUNX1T1
863	positive regulation of protein catabolic process (GO:0045732)	2/130	0.3740455	1.0000000	0	0	1.5384615	1.5128889	GJA1;GPC3
864	response to glucocorticoid (GO:0051384)	2/130	0.3740455	1.0000000	0	0	1.5384615	1.5128889	SCGB1A1;ABCG2
865	positive regulation of homeostatic process (GO:0032846)	2/130	0.3740455	1.0000000	0	0	1.5384615	1.5128889	MC4R;PLA2G1B
866	circulatory system process (GO:0003013)	2/130	0.3740455	1.0000000	0	0	1.5384615	1.5128889	NPPC;RAMP2
867	fatty acid beta-oxidation (GO:0006635)	1/47	0.3768149	1.0000000	0	0	2.1276596	2.0765984	ACOXL
868	regulation of synaptic transmission, glutamatergic (GO:0051966)	1/47	0.3768149	1.0000000	0	0	2.1276596	2.0765984	GRIK1
869	neural precursor cell proliferation (GO:0061351)	1/47	0.3768149	1.0000000	0	0	2.1276596	2.0765984	HHIP
870	negative regulation of synaptic transmission (GO:0050805)	1/47	0.3768149	1.0000000	0	0	2.1276596	2.0765984	GRIK1
871	acid secretion (GO:0046717)	1/47	0.3768149	1.0000000	0	0	2.1276596	2.0765984	PLA2G1B
872	skeletal muscle cell differentiation (GO:0035914)	1/47	0.3768149	1.0000000	0	0	2.1276596	2.0765984	HLF
873	cellular response to UV (GO:0034644)	1/47	0.3768149	1.0000000	0	0	2.1276596	2.0765984	MFAP4
874	negative regulation of growth (GO:0045926)	3/221	0.3805444	1.0000000	0	0	1.3574661	1.3115190	GJA1;GPC3;SCGB3A1
875	purine nucleotide biosynthetic process (GO:0006164)	2/132	0.3811749	1.0000000	0	0	1.5151515	1.4613592	NPPC;RAMP2
876	cellular response to biotic stimulus (GO:0071216)	2/132	0.3811749	1.0000000	0	0	1.5151515	1.4613592	CX3CR1;CCL5
877	positive regulation of alpha-beta T cell activation (GO:0046635)	1/48	0.3830614	1.0000000	0	0	2.0833333	1.9990833	HLA-DQB2
878	natural killer cell activation (GO:0030101)	1/48	0.3830614	1.0000000	0	0	2.0833333	1.9990833	KLRK1
879	intrinsic apoptotic signaling pathway by p53 class mediator (GO:0072332)	1/48	0.3830614	1.0000000	0	0	2.0833333	1.9990833	ZNF385B
880	regulation of mRNA stability (GO:0043488)	1/48	0.3830614	1.0000000	0	0	2.0833333	1.9990833	SCGB1A1
881	regulation of homeostatic process (GO:0032844)	4/314	0.3844827	1.0000000	0	0	1.2738854	1.2176516	MC4R;GJA1;PLA2G1B;ALOX12
882	regulation of blood pressure (GO:0008217)	2/133	0.3847268	1.0000000	0	0	1.5037594	1.4364239	RAMP2;OR51E2
883	positive regulation of immune effector process (GO:0002699)	2/133	0.3847268	1.0000000	0	0	1.5037594	1.4364239	KLRK1;CRTAM
884	cellular response to lipid (GO:0071396)	4/315	0.3867452	1.0000000	0	0	1.2698413	1.2063355	CX3CR1;CCL5;OR51E2;ALOX12
885	amine metabolic process (GO:0009308)	2/134	0.3882699	1.0000000	0	0	1.4925373	1.4120217	DDC;PLA2G1B
886	lipid modification (GO:0030258)	2/134	0.3882699	1.0000000	0	0	1.4925373	1.4120217	ACOXL;ALOX12
887	cellular response to drug (GO:0035690)	1/49	0.3892456	1.0000000	0	0	2.0408163	1.9256015	DDC
888	positive regulation of fibroblast proliferation (GO:0048146)	1/49	0.3892456	1.0000000	0	0	2.0408163	1.9256015	PLA2G1B
889	response to dsRNA (GO:0043331)	1/49	0.3892456	1.0000000	0	0	2.0408163	1.9256015	IFIT1
890	synapse assembly (GO:0007416)	1/49	0.3892456	1.0000000	0	0	2.0408163	1.9256015	GPM6A
891	developmental cell growth (GO:0048588)	1/49	0.3892456	1.0000000	0	0	2.0408163	1.9256015	DCX
892	regulation of lymphocyte apoptotic process (GO:0070228)	1/49	0.3892456	1.0000000	0	0	2.0408163	1.9256015	CCL5
893	antigen processing and presentation (GO:0019882)	3/225	0.3913564	1.0000000	0	0	1.3333333	1.2508489	CD207;HLA-DOA;HLA-DQB2
894	inositol lipid-mediated signaling (GO:0048017)	2/136	0.3953292	1.0000000	0	0	1.4705882	1.3647595	FGF9;FGF18
895	phosphatidylinositol-mediated signaling (GO:0048015)	2/136	0.3953292	1.0000000	0	0	1.4705882	1.3647595	FGF9;FGF18
896	cellular modified amino acid biosynthetic process (GO:0042398)	1/50	0.3953682	1.0000000	0	0	2.0000000	1.8558758	PADI3
897	endothelial cell migration (GO:0043542)	1/50	0.3953682	1.0000000	0	0	2.0000000	1.8558758	GPR124
898	regulation of cell junction assembly (GO:1901888)	1/50	0.3953682	1.0000000	0	0	2.0000000	1.8558758	GJA1
899	negative regulation of protein binding (GO:0032091)	1/50	0.3953682	1.0000000	0	0	2.0000000	1.8558758	IFIT1
900	cell projection morphogenesis (GO:0048858)	3/228	0.3994350	1.0000000	0	0	1.3157895	1.2075055	GPM6A;GJA1;DCX
901	positive regulation of proteolysis (GO:0045862)	3/228	0.3994350	1.0000000	0	0	1.3157895	1.2075055	PCOLCE2;DLC1;ALOX12
902	response to lipopolysaccharide (GO:0032496)	3/228	0.3994350	1.0000000	0	0	1.3157895	1.2075055	CX3CR1;CCL5;SCGB1A1
903	positive regulation of phosphatidylinositol 3-kinase signaling (GO:0014068)	1/51	0.4014296	1.0000000	0	0	1.9607843	1.7896531	CCL5
904	regulation of potassium ion transport (GO:0043266)	1/51	0.4014296	1.0000000	0	0	1.9607843	1.7896531	KCNJ1
905	regulation of glucose import (GO:0046324)	1/51	0.4014296	1.0000000	0	0	1.9607843	1.7896531	GPC3
906	regulation of neurotransmitter secretion (GO:0046928)	1/51	0.4014296	1.0000000	0	0	1.9607843	1.7896531	SNCG
907	positive regulation of axonogenesis (GO:0050772)	1/51	0.4014296	1.0000000	0	0	1.9607843	1.7896531	ROBO2
908	regulation of RNA stability (GO:0043487)	1/51	0.4014296	1.0000000	0	0	1.9607843	1.7896531	SCGB1A1
909	negative regulation of response to wounding (GO:1903035)	2/138	0.4023514	1.0000000	0	0	1.4492754	1.3194631	PROS1;ALOX12
910	response to light stimulus (GO:0009416)	4/322	0.4025512	1.0000000	0	0	1.2422360	1.1303516	MFAP4;OPN1SW;GPC3;CNGA1
911	endocytosis (GO:0006897)	4/323	0.4048039	1.0000000	0	0	1.2383901	1.1199413	RAMP2;SFTPD;CLEC4F;LRP1B
912	regulation of hormone secretion (GO:0046883)	3/230	0.4048048	1.0000000	0	0	1.3043478	1.1795874	KISS1;CCL5;SCG5
913	negative regulation of peptidase activity (GO:0010466)	3/230	0.4048048	1.0000000	0	0	1.3043478	1.1795874	PROS1;GPC3;A2ML1
914	protein homooligomerization (GO:0051260)	3/230	0.4048048	1.0000000	0	0	1.3043478	1.1795874	SCUBE1;KCNA3;KCNA4
915	immune response-activating cell surface receptor signaling pathway (GO:0002429)	4/324	0.4070550	1.0000000	0	0	1.2345679	1.1096382	IGHG4;TRAC;SKAP1;HLA-DQB2
916	positive regulation of epithelial cell differentiation (GO:0030858)	1/52	0.4074306	1.0000000	0	0	1.9230769	1.7267012	ALOX12
917	defense response to Gram-positive bacterium (GO:0050830)	1/52	0.4074306	1.0000000	0	0	1.9230769	1.7267012	PLA2G1B
918	demethylation (GO:0070988)	1/52	0.4074306	1.0000000	0	0	1.9230769	1.7267012	APOBEC2
919	regulation of pH (GO:0006885)	1/52	0.4074306	1.0000000	0	0	1.9230769	1.7267012	SLC4A10
920	regulation of vasoconstriction (GO:0019229)	1/52	0.4074306	1.0000000	0	0	1.9230769	1.7267012	GJA1
921	regulation of excitatory postsynaptic membrane potential (GO:0060079)	1/52	0.4074306	1.0000000	0	0	1.9230769	1.7267012	GRIK1
922	regulation of phagocytosis (GO:0050764)	1/52	0.4074306	1.0000000	0	0	1.9230769	1.7267012	SFTPD
923	positive regulation of lipid biosynthetic process (GO:0046889)	1/52	0.4074306	1.0000000	0	0	1.9230769	1.7267012	FABP3
924	regulation of interleukin-8 production (GO:0032677)	1/52	0.4074306	1.0000000	0	0	1.9230769	1.7267012	BPI
925	positive regulation of protein transport (GO:0051222)	3/231	0.4074846	1.0000000	0	0	1.2987013	1.1659119	PLA2G1B;CRTAM;OR51E2
926	ribonucleotide biosynthetic process (GO:0009260)	2/140	0.4093351	1.0000000	0	0	1.4285714	1.2760304	NPPC;RAMP2
927	response to corticosteroid (GO:0031960)	2/140	0.4093351	1.0000000	0	0	1.4285714	1.2760304	SCGB1A1;ABCG2
928	multi-organism reproductive process (GO:0044703)	2/140	0.4093351	1.0000000	0	0	1.4285714	1.2760304	RAMP2;SCGB1A1
929	cell-substrate adhesion (GO:0031589)	2/140	0.4093351	1.0000000	0	0	1.4285714	1.2760304	ECM2;PPFIA2
930	adult behavior (GO:0030534)	2/141	0.4128121	1.0000000	0	0	1.4184397	1.2549827	SNCG;GRIK1
931	branching morphogenesis of an epithelial tube (GO:0048754)	2/141	0.4128121	1.0000000	0	0	1.4184397	1.2549827	HHIP;GPC3
932	forebrain development (GO:0030900)	1/53	0.4133717	1.0000000	0	0	1.8867925	1.6668075	DLC1
933	regulation of tyrosine phosphorylation of STAT protein (GO:0042509)	1/53	0.4133717	1.0000000	0	0	1.8867925	1.6668075	CCL5
934	pyridine nucleotide metabolic process (GO:0019362)	1/53	0.4133717	1.0000000	0	0	1.8867925	1.6668075	QPRT
935	regulation of protein tyrosine kinase activity (GO:0061097)	1/53	0.4133717	1.0000000	0	0	1.8867925	1.6668075	CCL5
936	nicotinamide nucleotide metabolic process (GO:0046496)	1/53	0.4133717	1.0000000	0	0	1.8867925	1.6668075	QPRT
937	lymphocyte mediated immunity (GO:0002449)	1/53	0.4133717	1.0000000	0	0	1.8867925	1.6668075	CRTAM
938	divalent metal ion transport (GO:0070838)	3/234	0.4155023	1.0000000	0	0	1.2820513	1.1259834	GPM6A;RAMP2;CCL5
939	homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)	2/142	0.4162790	1.0000000	0	0	1.4084507	1.2343655	ROBO2;CDH7
940	digestive tract development (GO:0048565)	1/54	0.4192536	1.0000000	0	0	1.8518519	1.6097765	FGF9
941	negative regulation of nuclear division (GO:0051784)	1/54	0.4192536	1.0000000	0	0	1.8518519	1.6097765	DMRT1
942	peptide hormone secretion (GO:0030072)	1/54	0.4192536	1.0000000	0	0	1.8518519	1.6097765	MC4R
943	keratinocyte differentiation (GO:0030216)	1/54	0.4192536	1.0000000	0	0	1.8518519	1.6097765	TGM3
944	regulation of cartilage development (GO:0061035)	1/54	0.4192536	1.0000000	0	0	1.8518519	1.6097765	FGF18
945	ribose phosphate biosynthetic process (GO:0046390)	2/144	0.4231821	1.0000000	0	0	1.3888889	1.1943787	NPPC;RAMP2
946	positive regulation of epithelial cell proliferation (GO:0050679)	2/144	0.4231821	1.0000000	0	0	1.3888889	1.1943787	FGF9;FLT4
947	positive regulation of nuclear division (GO:0051785)	1/55	0.4250768	1.0000000	0	0	1.8181818	1.5554281	DMRT1
948	peptidyl-proline modification (GO:0018208)	1/55	0.4250768	1.0000000	0	0	1.8181818	1.5554281	P4HA3
949	arachidonic acid metabolic process (GO:0019369)	1/55	0.4250768	1.0000000	0	0	1.8181818	1.5554281	ALOX12
950	embryonic digit morphogenesis (GO:0042733)	1/55	0.4250768	1.0000000	0	0	1.8181818	1.5554281	GJA1
951	mesenchyme development (GO:0060485)	1/55	0.4250768	1.0000000	0	0	1.8181818	1.5554281	FGF9
952	heart looping (GO:0001947)	1/55	0.4250768	1.0000000	0	0	1.8181818	1.5554281	GJA1
953	divalent inorganic cation transport (GO:0072511)	3/238	0.4261388	1.0000000	0	0	1.2605042	1.0751978	GPM6A;RAMP2;CCL5
954	purine-containing compound biosynthetic process (GO:0072522)	2/146	0.4300432	1.0000000	0	0	1.3698630	1.1559858	NPPC;RAMP2
955	regulation of stress fiber assembly (GO:0051492)	1/56	0.4308418	1.0000000	0	0	1.7857143	1.5035968	DLC1
956	peptide secretion (GO:0002790)	1/56	0.4308418	1.0000000	0	0	1.7857143	1.5035968	MC4R
957	positive regulation of JAK-STAT cascade (GO:0046427)	1/56	0.4308418	1.0000000	0	0	1.7857143	1.5035968	CCL5
958	positive regulation of leukocyte chemotaxis (GO:0002690)	1/56	0.4308418	1.0000000	0	0	1.7857143	1.5035968	CCL5
959	DNA methylation or demethylation (GO:0044728)	1/56	0.4308418	1.0000000	0	0	1.7857143	1.5035968	APOBEC2
960	positive regulation of protein processing (GO:0010954)	3/240	0.4314322	1.0000000	0	0	1.2500000	1.0508061	PCOLCE2;DLC1;ALOX12
961	positive regulation of protein maturation (GO:1903319)	3/240	0.4314322	1.0000000	0	0	1.2500000	1.0508061	PCOLCE2;DLC1;ALOX12
962	cellular response to acid chemical (GO:0071229)	2/147	0.4334576	1.0000000	0	0	1.3605442	1.1373622	OR51E2;SNCG
963	response to hypoxia (GO:0001666)	3/241	0.4340724	1.0000000	0	0	1.2448133	1.0388512	NPPC;RAMP2;KCNK3
964	adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains (GO:0002460)	1/57	0.4365494	1.0000000	0	0	1.7543860	1.4541294	CRTAM
965	actomyosin structure organization (GO:0031032)	1/57	0.4365494	1.0000000	0	0	1.7543860	1.4541294	MYOZ1
966	establishment of synaptic vesicle localization (GO:0097480)	1/57	0.4365494	1.0000000	0	0	1.7543860	1.4541294	DDC
967	synaptic vesicle transport (GO:0048489)	1/57	0.4365494	1.0000000	0	0	1.7543860	1.4541294	DDC
968	insulin receptor signaling pathway (GO:0008286)	2/148	0.4368612	1.0000000	0	0	1.3513514	1.1191078	FGF9;FGF18
969	response to molecule of bacterial origin (GO:0002237)	3/243	0.4393395	1.0000000	0	0	1.2345679	1.0154110	CX3CR1;CCL5;SCGB1A1
970	regulation of cell-substrate adhesion (GO:0010810)	2/149	0.4402537	1.0000000	0	0	1.3422819	1.1012136	SMOC2;ECM2
971	regulation of postsynaptic membrane potential (GO:0060078)	1/58	0.4422000	1.0000000	0	0	1.7241379	1.4068845	GRIK1
972	regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001239)	1/58	0.4422000	1.0000000	0	0	1.7241379	1.4068845	CX3CR1
973	response to decreased oxygen levels (GO:0036293)	3/245	0.4445880	1.0000000	0	0	1.2244898	0.9925803	NPPC;RAMP2;KCNK3
974	regulation of synaptic transmission (GO:0050804)	3/245	0.4445880	1.0000000	0	0	1.2244898	0.9925803	KISS1;SNCG;GRIK1
975	cellular response to nitrogen compound (GO:1901699)	5/438	0.4461310	1.0000000	0	0	1.1415525	0.9213957	DDC;FGF9;PLA2G1B;FGF18;IFIT1
976	positive regulation of osteoblast differentiation (GO:0045669)	1/59	0.4477942	1.0000000	0	0	1.6949153	1.3617314	NPPC
977	chondroitin sulfate metabolic process (GO:0030204)	1/59	0.4477942	1.0000000	0	0	1.6949153	1.3617314	GPC3
978	steroid hormone mediated signaling pathway (GO:0043401)	1/59	0.4477942	1.0000000	0	0	1.6949153	1.3617314	OR51E2
979	regulation of inflammatory response (GO:0050727)	3/247	0.4498174	1.0000000	0	0	1.2145749	0.9703403	PROS1;CCL5;SCGB1A1
980	cell part morphogenesis (GO:0032990)	3/248	0.4524247	1.0000000	0	0	1.2096774	0.9594361	GPM6A;GJA1;DCX
981	glycosaminoglycan catabolic process (GO:0006027)	1/60	0.4533326	1.0000000	0	0	1.6666667	1.3185487	GPC3
982	cellular defense response (GO:0006968)	1/60	0.4533326	1.0000000	0	0	1.6666667	1.3185487	CX3CR1
983	positive regulation of DNA replication (GO:0045740)	1/60	0.4533326	1.0000000	0	0	1.6666667	1.3185487	PLA2G1B
984	inner ear morphogenesis (GO:0042472)	1/60	0.4533326	1.0000000	0	0	1.6666667	1.3185487	FGF9
985	pyridine-containing compound metabolic process (GO:0072524)	1/61	0.4588157	1.0000000	0	0	1.6393443	1.2772240	QPRT
986	cholesterol homeostasis (GO:0042632)	1/61	0.4588157	1.0000000	0	0	1.6393443	1.2772240	FABP3
987	double-strand break repair via homologous recombination (GO:0000724)	1/61	0.4588157	1.0000000	0	0	1.6393443	1.2772240	MEIOB
988	kidney epithelium development (GO:0072073)	1/62	0.4642441	1.0000000	0	0	1.6129032	1.2376529	ROBO2
989	regulation of adenylate cyclase activity (GO:0045761)	1/62	0.4642441	1.0000000	0	0	1.6129032	1.2376529	GABBR2
990	embryonic heart tube morphogenesis (GO:0003143)	1/62	0.4642441	1.0000000	0	0	1.6129032	1.2376529	GJA1
991	regulation of cation channel activity (GO:2001257)	1/62	0.4642441	1.0000000	0	0	1.6129032	1.2376529	KCNJ1
992	recombinational repair (GO:0000725)	1/62	0.4642441	1.0000000	0	0	1.6129032	1.2376529	MEIOB
993	negative regulation of G-protein coupled receptor protein signaling pathway (GO:0045744)	1/62	0.4642441	1.0000000	0	0	1.6129032	1.2376529	CCL5
994	phosphatidylcholine metabolic process (GO:0046470)	1/62	0.4642441	1.0000000	0	0	1.6129032	1.2376529	PLA2G1B
995	regulation of actin filament bundle assembly (GO:0032231)	1/62	0.4642441	1.0000000	0	0	1.6129032	1.2376529	DLC1
996	sterol homeostasis (GO:0055092)	1/62	0.4642441	1.0000000	0	0	1.6129032	1.2376529	FABP3
997	stem cell differentiation (GO:0048863)	1/62	0.4642441	1.0000000	0	0	1.6129032	1.2376529	GPM6A
998	regulation of innate immune response (GO:0045088)	3/254	0.4679607	1.0000000	0	0	1.1811024	0.8968947	KLRK1;CCL5;CRTAM
999	regulation of alpha-beta T cell activation (GO:0046634)	1/63	0.4696183	1.0000000	0	0	1.5873016	1.1997381	HLA-DQB2
1000	modification of morphology or physiology of other organism involved in symbiotic interaction (GO:0051817)	1/63	0.4696183	1.0000000	0	0	1.5873016	1.1997381	CCL5
1001	positive regulation of endothelial cell proliferation (GO:0001938)	1/63	0.4696183	1.0000000	0	0	1.5873016	1.1997381	FLT4
1002	regulation of blood vessel size (GO:0050880)	1/63	0.4696183	1.0000000	0	0	1.5873016	1.1997381	NPPC
1003	neural nucleus development (GO:0048857)	1/63	0.4696183	1.0000000	0	0	1.5873016	1.1997381	FGF9
1004	regulation of neurotransmitter transport (GO:0051588)	1/63	0.4696183	1.0000000	0	0	1.5873016	1.1997381	SNCG
1005	energy reserve metabolic process (GO:0006112)	2/158	0.4702715	1.0000000	0	0	1.2658228	0.9549937	MC4R;LEPR
1006	epithelium development (GO:0060429)	3/256	0.4730965	1.0000000	0	0	1.1718750	0.8770968	ROBO2;GJA1;EMP1
1007	regulation of endopeptidase activity (GO:0052548)	4/354	0.4735741	1.0000000	0	0	1.1299435	0.8445728	DLC1;PROS1;ALOX12;A2ML1
1008	negative regulation of angiogenesis (GO:0016525)	1/64	0.4749389	1.0000000	0	0	1.5625000	1.1633893	CX3CR1
1009	fatty acid catabolic process (GO:0009062)	1/64	0.4749389	1.0000000	0	0	1.5625000	1.1633893	ACOXL
1010	regulation of tube size (GO:0035150)	1/64	0.4749389	1.0000000	0	0	1.5625000	1.1633893	NPPC
1011	regulation of synapse organization (GO:0050807)	1/64	0.4749389	1.0000000	0	0	1.5625000	1.1633893	ROBO2
1012	positive regulation of stem cell proliferation (GO:2000648)	1/64	0.4749389	1.0000000	0	0	1.5625000	1.1633893	FGF9
1013	meiotic nuclear division (GO:0007126)	1/64	0.4749389	1.0000000	0	0	1.5625000	1.1633893	MEIOB
1014	multicellular organismal development (GO:0007275)	5/453	0.4752146	1.0000000	0	0	1.1037528	0.8211796	ST6GAL2;HLF;LEPR;EMP1;TBX4
1015	epithelial cell migration (GO:0010631)	1/65	0.4802063	1.0000000	0	0	1.5384615	1.1285222	GPR124
1016	negative regulation of phosphatase activity (GO:0010923)	1/65	0.4802063	1.0000000	0	0	1.5384615	1.1285222	SLC7A14
1017	oxidoreduction coenzyme metabolic process (GO:0006733)	1/65	0.4802063	1.0000000	0	0	1.5384615	1.1285222	QPRT
1018	positive regulation of peptide hormone secretion (GO:0090277)	1/65	0.4802063	1.0000000	0	0	1.5384615	1.1285222	KISS1
1019	response to oxygen levels (GO:0070482)	3/259	0.4807580	1.0000000	0	0	1.1583012	0.8483297	NPPC;RAMP2;KCNK3
1020	tissue morphogenesis (GO:0048729)	4/358	0.4822501	1.0000000	0	0	1.1173184	0.8148519	GJA1;HHIP;GPC3;TBX4
1021	morphogenesis of a branching epithelium (GO:0061138)	2/162	0.4833031	1.0000000	0	0	1.2345679	0.8976684	HHIP;GPC3
1022	skeletal system development (GO:0001501)	2/162	0.4833031	1.0000000	0	0	1.2345679	0.8976684	FGF9;FBN1
1023	regulation of acute inflammatory response (GO:0002673)	1/66	0.4854212	1.0000000	0	0	1.5151515	1.0950581	PROS1
1024	negative regulation of cell division (GO:0051782)	1/66	0.4854212	1.0000000	0	0	1.5151515	1.0950581	DMRT1
1025	regulation of translational initiation (GO:0006446)	1/66	0.4854212	1.0000000	0	0	1.5151515	1.0950581	CCL5
1026	regulation of bone mineralization (GO:0030500)	1/66	0.4854212	1.0000000	0	0	1.5151515	1.0950581	GJA1
1027	regulation of phosphatidylinositol 3-kinase signaling (GO:0014066)	1/66	0.4854212	1.0000000	0	0	1.5151515	1.0950581	CCL5
1028	positive regulation of translation (GO:0045727)	1/66	0.4854212	1.0000000	0	0	1.5151515	1.0950581	CCL5
1029	dorsal/ventral pattern formation (GO:0009953)	1/66	0.4854212	1.0000000	0	0	1.5151515	1.0950581	HHIP
1030	negative regulation of blood vessel morphogenesis (GO:2000181)	1/66	0.4854212	1.0000000	0	0	1.5151515	1.0950581	CX3CR1
1031	multicellular organismal response to stress (GO:0033555)	1/66	0.4854212	1.0000000	0	0	1.5151515	1.0950581	GRIK1
1032	response to ammonium ion (GO:0060359)	1/66	0.4854212	1.0000000	0	0	1.5151515	1.0950581	SNCG
1033	cellular response to peptide hormone stimulus (GO:0071375)	3/261	0.4858368	1.0000000	0	0	1.1494253	0.8297501	FGF9;PLA2G1B;FGF18
1034	fibroblast growth factor receptor signaling pathway (GO:0008543)	2/163	0.4865301	1.0000000	0	0	1.2269939	0.8839957	FGF9;FGF18
1035	developmental growth (GO:0048589)	2/163	0.4865301	1.0000000	0	0	1.2269939	0.8839957	GJA1;DCX
1036	tube development (GO:0035295)	2/164	0.4897447	1.0000000	0	0	1.2195122	0.8705745	ROBO2;FGF9
1037	vasculogenesis (GO:0001570)	1/67	0.4905840	1.0000000	0	0	1.4925373	1.0629235	RAMP2
1038	aminoglycan catabolic process (GO:0006026)	1/67	0.4905840	1.0000000	0	0	1.4925373	1.0629235	GPC3
1039	protein secretion (GO:0009306)	1/67	0.4905840	1.0000000	0	0	1.4925373	1.0629235	SNCG
1040	cellular iron ion homeostasis (GO:0006879)	1/67	0.4905840	1.0000000	0	0	1.4925373	1.0629235	ABCG2
1041	cellular response to mechanical stimulus (GO:0071260)	1/67	0.4905840	1.0000000	0	0	1.4925373	1.0629235	GJA1
1042	positive regulation of peptide secretion (GO:0002793)	1/67	0.4905840	1.0000000	0	0	1.4925373	1.0629235	KISS1
1043	regulation of endocytosis (GO:0030100)	2/165	0.4929467	1.0000000	0	0	1.2121212	0.8573991	SFTPD;GPC3
1044	cytokine production (GO:0001816)	1/68	0.4956953	1.0000000	0	0	1.4705882	1.0320498	PLA2G1B
1045	regulation of leukocyte chemotaxis (GO:0002688)	1/68	0.4956953	1.0000000	0	0	1.4705882	1.0320498	CCL5
1046	glucose transport (GO:0015758)	1/68	0.4956953	1.0000000	0	0	1.4705882	1.0320498	PLA2G1B
1047	regulation of DNA metabolic process (GO:0051052)	3/265	0.4959228	1.0000000	0	0	1.1320755	0.7939642	NPPC;APOBEC3H;PLA2G1B
1048	negative regulation of cell migration (GO:0030336)	2/166	0.4961360	1.0000000	0	0	1.2048193	0.8444640	CX3CR1;DLC1
1049	regulation of membrane potential (GO:0042391)	3/266	0.4984290	1.0000000	0	0	1.1278195	0.7852941	GJA1;CNGA1;GRIK1
1050	hexose transport (GO:0008645)	1/69	0.5007555	1.0000000	0	0	1.4492754	1.0023729	PLA2G1B
1051	molting cycle process (GO:0022404)	1/69	0.5007555	1.0000000	0	0	1.4492754	1.0023729	TGM3
1052	positive regulation of cytokine secretion (GO:0050715)	1/69	0.5007555	1.0000000	0	0	1.4492754	1.0023729	CRTAM
1053	hair cycle process (GO:0022405)	1/69	0.5007555	1.0000000	0	0	1.4492754	1.0023729	TGM3
1054	alpha-amino acid biosynthetic process (GO:1901607)	1/69	0.5007555	1.0000000	0	0	1.4492754	1.0023729	PADI3
1055	action potential (GO:0001508)	1/69	0.5007555	1.0000000	0	0	1.4492754	1.0023729	GJA1
1056	hormone secretion (GO:0046879)	1/70	0.5057652	1.0000000	0	0	1.4285714	0.9738324	MC4R
1057	negative regulation of dephosphorylation (GO:0035305)	1/70	0.5057652	1.0000000	0	0	1.4285714	0.9738324	SLC7A14
1058	response to heat (GO:0009408)	1/70	0.5057652	1.0000000	0	0	1.4285714	0.9738324	STAC
1059	positive regulation of muscle cell differentiation (GO:0051149)	1/70	0.5057652	1.0000000	0	0	1.4285714	0.9738324	HOPX
1060	negative regulation of vasculature development (GO:1901343)	1/70	0.5057652	1.0000000	0	0	1.4285714	0.9738324	CX3CR1
1061	response to steroid hormone (GO:0048545)	4/369	0.5058127	1.0000000	0	0	1.0840108	0.7388497	RAMP2;OR51E2;SCGB1A1;ABCG2
1062	response to inorganic substance (GO:0010035)	4/370	0.5079318	1.0000000	0	0	1.0810811	0.7323331	SCGB1A1;SNCG;KCNK3;ABCG2
1063	negative regulation of cell motility (GO:2000146)	2/170	0.5087658	1.0000000	0	0	1.1764706	0.7950205	CX3CR1;DLC1
1064	MAPK cascade (GO:0000165)	2/170	0.5087658	1.0000000	0	0	1.1764706	0.7950205	DOK5;CCL5
1065	morphogenesis of a branching structure (GO:0001763)	2/170	0.5087658	1.0000000	0	0	1.1764706	0.7950205	HHIP;GPC3
1066	tissue remodeling (GO:0048771)	1/71	0.5107249	1.0000000	0	0	1.4084507	0.9463720	GJA1
1067	response to interleukin-1 (GO:0070555)	1/71	0.5107249	1.0000000	0	0	1.4084507	0.9463720	CCL5
1068	single-organism nuclear import (GO:1902593)	1/71	0.5107249	1.0000000	0	0	1.4084507	0.9463720	FGF9
1069	regulation of leukocyte apoptotic process (GO:2000106)	1/71	0.5107249	1.0000000	0	0	1.4084507	0.9463720	CCL5
1070	receptor metabolic process (GO:0043112)	1/71	0.5107249	1.0000000	0	0	1.4084507	0.9463720	RAMP2
1071	monosaccharide transport (GO:0015749)	1/71	0.5107249	1.0000000	0	0	1.4084507	0.9463720	PLA2G1B
1072	organophosphate ester transport (GO:0015748)	1/71	0.5107249	1.0000000	0	0	1.4084507	0.9463720	GJA1
1073	positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains (GO:0002824)	1/71	0.5107249	1.0000000	0	0	1.4084507	0.9463720	HLA-DQB2
1074	protein import into nucleus (GO:0006606)	1/71	0.5107249	1.0000000	0	0	1.4084507	0.9463720	FGF9
1075	biomineral tissue development (GO:0031214)	1/71	0.5107249	1.0000000	0	0	1.4084507	0.9463720	GPC3
1076	monocarboxylic acid metabolic process (GO:0032787)	5/473	0.5131956	1.0000000	0	0	1.0570825	0.7051778	CH25H;FABP3;ACOXL;PLA2G1B;ALOX12
1077	smoothened signaling pathway (GO:0007224)	1/72	0.5156351	1.0000000	0	0	1.3888889	0.9199388	HHIP
1078	regulation of fatty acid metabolic process (GO:0019217)	1/72	0.5156351	1.0000000	0	0	1.3888889	0.9199388	FABP3
1079	regulation of multicellular organism growth (GO:0040014)	1/72	0.5156351	1.0000000	0	0	1.3888889	0.9199388	NPPC
1080	regulation of calcium ion transport into cytosol (GO:0010522)	1/72	0.5156351	1.0000000	0	0	1.3888889	0.9199388	PLA2G1B
1081	negative regulation of purine nucleotide metabolic process (GO:1900543)	1/72	0.5156351	1.0000000	0	0	1.3888889	0.9199388	GABBR2
1082	regulation of biomineral tissue development (GO:0070167)	1/72	0.5156351	1.0000000	0	0	1.3888889	0.9199388	GJA1
1083	peptide transport (GO:0015833)	1/72	0.5156351	1.0000000	0	0	1.3888889	0.9199388	MC4R
1084	cellular response to peptide (GO:1901653)	3/273	0.5157953	1.0000000	0	0	1.0989011	0.7275222	FGF9;PLA2G1B;FGF18
1085	regulation of ossification (GO:0030278)	2/173	0.5181024	1.0000000	0	0	1.1560694	0.7602108	NPPC;GJA1
1086	positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway (GO:0090100)	1/73	0.5204962	1.0000000	0	0	1.3698630	0.8944830	GPC3
1087	regulation of cyclase activity (GO:0031279)	1/73	0.5204962	1.0000000	0	0	1.3698630	0.8944830	GABBR2
1088	positive regulation of adaptive immune response (GO:0002821)	1/74	0.5253088	1.0000000	0	0	1.3513514	0.8699580	HLA-DQB2
1089	nuclear import (GO:0051170)	1/75	0.5300734	1.0000000	0	0	1.3333333	0.8463198	FGF9
1090	regulation of fibroblast proliferation (GO:0048145)	1/75	0.5300734	1.0000000	0	0	1.3333333	0.8463198	PLA2G1B
1091	muscle cell development (GO:0055001)	1/75	0.5300734	1.0000000	0	0	1.3333333	0.8463198	RAMP2
1092	negative regulation of nucleotide metabolic process (GO:0045980)	1/75	0.5300734	1.0000000	0	0	1.3333333	0.8463198	GABBR2
1093	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:0002479)	1/75	0.5300734	1.0000000	0	0	1.3333333	0.8463198	CD207
1094	hormone transport (GO:0009914)	1/75	0.5300734	1.0000000	0	0	1.3333333	0.8463198	MC4R
1095	response to vitamin (GO:0033273)	1/75	0.5300734	1.0000000	0	0	1.3333333	0.8463198	ABCG2
1096	regulation of cellular ketone metabolic process (GO:0010565)	2/178	0.5334006	1.0000000	0	0	1.1235955	0.7061602	FABP3;LEPR
1097	regulation of JAK-STAT cascade (GO:0046425)	1/76	0.5347903	1.0000000	0	0	1.3157895	0.8235271	CCL5
1098	neural tube closure (GO:0001843)	1/76	0.5347903	1.0000000	0	0	1.3157895	0.8235271	DLC1
1099	modification of morphology or physiology of other organism (GO:0035821)	1/76	0.5347903	1.0000000	0	0	1.3157895	0.8235271	CCL5
1100	epidermal cell differentiation (GO:0009913)	1/76	0.5347903	1.0000000	0	0	1.3157895	0.8235271	TGM3
1101	regulation of viral transcription (GO:0046782)	1/76	0.5347903	1.0000000	0	0	1.3157895	0.8235271	CCL5
1102	tube closure (GO:0060606)	1/77	0.5394601	1.0000000	0	0	1.2987013	0.8015408	DLC1
1103	regulation of lyase activity (GO:0051339)	1/77	0.5394601	1.0000000	0	0	1.2987013	0.8015408	GABBR2
1104	regulation of DNA binding (GO:0051101)	1/77	0.5394601	1.0000000	0	0	1.2987013	0.8015408	RUNX1T1
1105	protein localization to plasma membrane (GO:0072659)	1/77	0.5394601	1.0000000	0	0	1.2987013	0.8015408	RAMP2
1106	axis specification (GO:0009798)	1/78	0.5440833	1.0000000	0	0	1.2820513	0.7803242	GPC3
1107	positive regulation of leukocyte migration (GO:0002687)	1/78	0.5440833	1.0000000	0	0	1.2820513	0.7803242	CCL5
1108	regulation of tumor necrosis factor production (GO:0032680)	1/78	0.5440833	1.0000000	0	0	1.2820513	0.7803242	BPI
1109	negative regulation of cellular component movement (GO:0051271)	2/183	0.5483655	1.0000000	0	0	1.0928962	0.6566265	CX3CR1;DLC1
1110	locomotory behavior (GO:0007626)	2/183	0.5483655	1.0000000	0	0	1.0928962	0.6566265	SNCG;FEZF2
1111	developmental growth involved in morphogenesis (GO:0060560)	1/79	0.5486603	1.0000000	0	0	1.2658228	0.7598427	DCX
1112	regulation of interferon-gamma production (GO:0032649)	1/79	0.5486603	1.0000000	0	0	1.2658228	0.7598427	SCGB1A1
1113	antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)	1/79	0.5486603	1.0000000	0	0	1.2658228	0.7598427	CD207
1114	regulation of carbohydrate biosynthetic process (GO:0043255)	1/79	0.5486603	1.0000000	0	0	1.2658228	0.7598427	LEPR
1115	behavior (GO:0007610)	5/494	0.5518315	1.0000000	0	0	1.0121457	0.6017334	MC4R;GRID1;SNCG;GRIK1;FEZF2
1116	regulation of tumor necrosis factor superfamily cytokine production (GO:1903555)	1/80	0.5531916	1.0000000	0	0	1.2500000	0.7400636	BPI
1117	multicellular organismal catabolic process (GO:0044243)	1/80	0.5531916	1.0000000	0	0	1.2500000	0.7400636	PLA2G1B
1118	regulation of cysteine-type endopeptidase activity involved in apoptotic process (GO:0043281)	2/186	0.5571827	1.0000000	0	0	1.0752688	0.6288839	DLC1;ALOX12
1119	small molecule biosynthetic process (GO:0044283)	4/394	0.5575014	1.0000000	0	0	1.0152284	0.5931881	CH25H;PLA2G1B;PADI3;ALOX12
1120	lymphocyte proliferation (GO:0046651)	1/81	0.5576776	1.0000000	0	0	1.2345679	0.7209558	CRTAM
1121	negative regulation of immune effector process (GO:0002698)	1/81	0.5576776	1.0000000	0	0	1.2345679	0.7209558	IFIT1
1122	platelet degranulation (GO:0002576)	1/81	0.5576776	1.0000000	0	0	1.2345679	0.7209558	PROS1
1123	phenol-containing compound metabolic process (GO:0018958)	1/81	0.5576776	1.0000000	0	0	1.2345679	0.7209558	DDC
1124	ethanolamine-containing compound metabolic process (GO:0042439)	1/81	0.5576776	1.0000000	0	0	1.2345679	0.7209558	PLA2G1B
1125	cellular response to organic cyclic compound (GO:0071407)	3/291	0.5589306	1.0000000	0	0	1.0309278	0.5997217	CCL5;OR51E2;IFIT1
1126	monocarboxylic acid catabolic process (GO:0072329)	1/82	0.5621188	1.0000000	0	0	1.2195122	0.7024903	ACOXL
1127	male gonad development (GO:0008584)	1/82	0.5621188	1.0000000	0	0	1.2195122	0.7024903	FGF9
1128	monovalent inorganic cation homeostasis (GO:0055067)	1/82	0.5621188	1.0000000	0	0	1.2195122	0.7024903	SLC4A10
1129	regulation of peptide hormone secretion (GO:0090276)	2/189	0.5658778	1.0000000	0	0	1.0582011	0.6025155	KISS1;CCL5
1130	negative regulation of protein kinase activity (GO:0006469)	2/189	0.5658778	1.0000000	0	0	1.0582011	0.6025155	CAMK2N1;DUSP26
1131	positive regulation of T cell proliferation (GO:0042102)	1/83	0.5665156	1.0000000	0	0	1.2048193	0.6846392	CCL5
1132	positive regulation of ossification (GO:0045778)	1/83	0.5665156	1.0000000	0	0	1.2048193	0.6846392	NPPC
1133	myeloid leukocyte differentiation (GO:0002573)	1/83	0.5665156	1.0000000	0	0	1.2048193	0.6846392	GPC3
1134	activation of cysteine-type endopeptidase activity involved in apoptotic process (GO:0006919)	1/83	0.5665156	1.0000000	0	0	1.2048193	0.6846392	DLC1
1135	amide transport (GO:0042886)	1/83	0.5665156	1.0000000	0	0	1.2048193	0.6846392	MC4R
1136	mononuclear cell proliferation (GO:0032943)	1/83	0.5665156	1.0000000	0	0	1.2048193	0.6846392	CRTAM
1137	cell-cell adhesion via plasma-membrane adhesion molecules (GO:0098742)	2/190	0.5687489	1.0000000	0	0	1.0526316	0.5940172	ROBO2;CDH7
1138	regulation of interleukin-6 production (GO:0032675)	1/84	0.5708685	1.0000000	0	0	1.1904762	0.6673766	BPI
1139	cell-cell adhesion (GO:0098609)	2/191	0.5716063	1.0000000	0	0	1.0471204	0.5856595	ROBO2;CDH7
1140	regulation of peptide secretion (GO:0002791)	2/192	0.5744500	1.0000000	0	0	1.0416667	0.5774397	KISS1;CCL5
1141	regulation of striated muscle cell differentiation (GO:0051153)	1/85	0.5751779	1.0000000	0	0	1.1764706	0.6506774	HOPX
1142	regulation of anion transport (GO:0044070)	1/85	0.5751779	1.0000000	0	0	1.1764706	0.6506774	GRIK1
1143	blood vessel development (GO:0001568)	1/85	0.5751779	1.0000000	0	0	1.1764706	0.6506774	GPC3
1144	embryonic morphogenesis (GO:0048598)	4/403	0.5753961	1.0000000	0	0	0.9925558	0.5485822	GJA1;FGF9;GPC3;TBX4
1145	lipid transport (GO:0006869)	2/193	0.5772801	1.0000000	0	0	1.0362694	0.5693551	FABP3;PLA2G1B
1146	epidermal growth factor receptor signaling pathway (GO:0007173)	2/193	0.5772801	1.0000000	0	0	1.0362694	0.5693551	FGF9;FGF18
1147	long-chain fatty acid metabolic process (GO:0001676)	1/86	0.5794443	1.0000000	0	0	1.1627907	0.6345183	ALOX12
1148	regulation of stem cell proliferation (GO:0072091)	1/86	0.5794443	1.0000000	0	0	1.1627907	0.6345183	FGF9
1149	response to amino acid (GO:0043200)	1/86	0.5794443	1.0000000	0	0	1.1627907	0.6345183	ABCG2
1150	visual perception (GO:0007601)	2/195	0.5828991	1.0000000	0	0	1.0256410	0.5535806	OPN1SW;CNGA1
1151	positive regulation of cell projection organization (GO:0031346)	2/195	0.5828991	1.0000000	0	0	1.0256410	0.5535806	ROBO2;GPM6A
1152	feeding behavior (GO:0007631)	1/87	0.5836680	1.0000000	0	0	1.1494253	0.6188770	MC4R
1153	dicarboxylic acid metabolic process (GO:0043648)	1/87	0.5836680	1.0000000	0	0	1.1494253	0.6188770	QPRT
1154	negative regulation of proteolysis (GO:0045861)	3/302	0.5841348	1.0000000	0	0	0.9933775	0.5340631	PROS1;GPC3;A2ML1
1155	ERBB signaling pathway (GO:0038127)	2/196	0.5856881	1.0000000	0	0	1.0204082	0.5458856	FGF9;FGF18
1156	activation of cysteine-type endopeptidase activity (GO:0097202)	1/88	0.5878495	1.0000000	0	0	1.1363636	0.6037322	DLC1
1157	regulation of endothelial cell proliferation (GO:0001936)	1/88	0.5878495	1.0000000	0	0	1.1363636	0.6037322	FLT4
1158	adult locomotory behavior (GO:0008344)	1/88	0.5878495	1.0000000	0	0	1.1363636	0.6037322	SNCG
1159	regulation of cysteine-type endopeptidase activity (GO:2000116)	2/197	0.5884633	1.0000000	0	0	1.0152284	0.5383154	DLC1;ALOX12
1160	positive regulation of MAP kinase activity (GO:0043406)	2/197	0.5884633	1.0000000	0	0	1.0152284	0.5383154	PLA2G1B;DIRAS2
1161	lymphocyte activation (GO:0046649)	3/304	0.5886188	1.0000000	0	0	0.9868421	0.5230032	KLRK1;CD8B;CRTAM
1162	cellular response to organonitrogen compound (GO:0071417)	4/411	0.5909584	1.0000000	0	0	0.9732360	0.5119315	DDC;FGF9;PLA2G1B;FGF18
1163	T cell activation (GO:0042110)	2/198	0.5912248	1.0000000	0	0	1.0101010	0.5308676	CD8B;CRTAM
1164	energy derivation by oxidation of organic compounds (GO:0015980)	2/198	0.5912248	1.0000000	0	0	1.0101010	0.5308676	MC4R;LEPR
1165	sensory perception of light stimulus (GO:0050953)	2/198	0.5912248	1.0000000	0	0	1.0101010	0.5308676	OPN1SW;CNGA1
1166	RNA modification (GO:0009451)	1/89	0.5919892	1.0000000	0	0	1.1235955	0.5890639	APOBEC2
1167	leukocyte proliferation (GO:0070661)	1/89	0.5919892	1.0000000	0	0	1.1235955	0.5890639	CRTAM
1168	cellular response to tumor necrosis factor (GO:0071356)	1/89	0.5919892	1.0000000	0	0	1.1235955	0.5890639	CCL5
1169	cellular transition metal ion homeostasis (GO:0046916)	1/89	0.5919892	1.0000000	0	0	1.1235955	0.5890639	ABCG2
1170	cellular modified amino acid metabolic process (GO:0006575)	2/199	0.5939726	1.0000000	0	0	1.0050251	0.5235399	PLA2G1B;PADI3
1171	positive regulation of chemotaxis (GO:0050921)	1/90	0.5960875	1.0000000	0	0	1.1111111	0.5748531	CCL5
1172	regulation of glucose transport (GO:0010827)	1/90	0.5960875	1.0000000	0	0	1.1111111	0.5748531	GPC3
1173	water-soluble vitamin metabolic process (GO:0006767)	1/90	0.5960875	1.0000000	0	0	1.1111111	0.5748531	QPRT
1174	carboxylic acid catabolic process (GO:0046395)	2/200	0.5967066	1.0000000	0	0	1.0000000	0.5163298	ACOXL;QPRT
1175	organic acid catabolic process (GO:0016054)	2/200	0.5967066	1.0000000	0	0	1.0000000	0.5163298	ACOXL;QPRT
1176	protein processing (GO:0016485)	2/201	0.5994269	1.0000000	0	0	0.9950249	0.5092351	DLC1;SCG5
1177	positive regulation of hormone secretion (GO:0046887)	1/91	0.6001449	1.0000000	0	0	1.0989011	0.5610815	KISS1
1178	negative regulation of canonical Wnt signaling pathway (GO:0090090)	1/91	0.6001449	1.0000000	0	0	1.0989011	0.5610815	GPC3
1179	adaptive immune response (GO:0002250)	1/91	0.6001449	1.0000000	0	0	1.0989011	0.5610815	CRTAM
1180	negative regulation of kinase activity (GO:0033673)	2/202	0.6021334	1.0000000	0	0	0.9900990	0.5022537	CAMK2N1;DUSP26
1181	signal transduction by phosphorylation (GO:0023014)	2/202	0.6021334	1.0000000	0	0	0.9900990	0.5022537	DOK5;CCL5
1182	iron ion homeostasis (GO:0055072)	1/92	0.6041617	1.0000000	0	0	1.0869565	0.5477319	ABCG2
1183	interaction with host (GO:0051701)	1/92	0.6041617	1.0000000	0	0	1.0869565	0.5477319	IFIT1
1184	aging (GO:0007568)	2/204	0.6075053	1.0000000	0	0	0.9803922	0.4886220	DDC;ALOX12
1185	regulation of cytokine biosynthetic process (GO:0042035)	1/93	0.6081384	1.0000000	0	0	1.0752688	0.5347880	SFTPD
1186	hormone-mediated signaling pathway (GO:0009755)	1/93	0.6081384	1.0000000	0	0	1.0752688	0.5347880	OR51E2
1187	meiotic cell cycle process (GO:1903046)	1/93	0.6081384	1.0000000	0	0	1.0752688	0.5347880	MEIOB
1188	regulation of glucose metabolic process (GO:0010906)	1/94	0.6120753	1.0000000	0	0	1.0638298	0.5222340	LEPR
1189	multicellular organismal metabolic process (GO:0044236)	1/94	0.6120753	1.0000000	0	0	1.0638298	0.5222340	PLA2G1B
1190	negative regulation of protein processing (GO:0010955)	3/316	0.6148691	1.0000000	0	0	0.9493671	0.4617208	PROS1;GPC3;A2ML1
1191	negative regulation of protein maturation (GO:1903318)	3/316	0.6148691	1.0000000	0	0	0.9493671	0.4617208	PROS1;GPC3;A2ML1
1192	regulation of cytokine-mediated signaling pathway (GO:0001959)	1/95	0.6159728	1.0000000	0	0	1.0526316	0.5100552	CCL5
1193	negative regulation of binding (GO:0051100)	1/95	0.6159728	1.0000000	0	0	1.0526316	0.5100552	IFIT1
1194	establishment of vesicle localization (GO:0051650)	1/95	0.6159728	1.0000000	0	0	1.0526316	0.5100552	DDC
1195	anatomical structure homeostasis (GO:0060249)	2/208	0.6180843	1.0000000	0	0	0.9615385	0.4626254	SFTPD;KCNJ1
1196	lipid homeostasis (GO:0055088)	1/96	0.6198314	1.0000000	0	0	1.0416667	0.4982372	FABP3
1197	fat cell differentiation (GO:0045444)	1/96	0.6198314	1.0000000	0	0	1.0416667	0.4982372	RUNX1T1
1198	regulation of T cell differentiation (GO:0045580)	1/97	0.6236514	1.0000000	0	0	1.0309278	0.4867667	HLA-DOA
1199	regeneration (GO:0031099)	1/97	0.6236514	1.0000000	0	0	1.0309278	0.4867667	GJA1
1200	negative regulation of extrinsic apoptotic signaling pathway (GO:2001237)	1/97	0.6236514	1.0000000	0	0	1.0309278	0.4867667	CX3CR1
1201	nucleosome assembly (GO:0006334)	1/97	0.6236514	1.0000000	0	0	1.0309278	0.4867667	NAP1L3
1202	coenzyme biosynthetic process (GO:0009108)	1/98	0.6274332	1.0000000	0	0	1.0204082	0.4756306	QPRT
1203	glycosaminoglycan biosynthetic process (GO:0006024)	1/99	0.6311772	1.0000000	0	0	1.0101010	0.4648167	GPC3
1204	cellular response to hypoxia (GO:0071456)	1/99	0.6311772	1.0000000	0	0	1.0101010	0.4648167	KCNK3
1205	cellular response to metal ion (GO:0071248)	1/99	0.6311772	1.0000000	0	0	1.0101010	0.4648167	KCNK3
1206	positive regulation of sequence-specific DNA binding transcription factor activity (GO:0051091)	2/214	0.6335421	1.0000000	0	0	0.9345794	0.4265691	BEX1;PLA2G1B
1207	aminoglycan biosynthetic process (GO:0006023)	1/100	0.6348838	1.0000000	0	0	1.0000000	0.4543133	GPC3
1208	response to estradiol (GO:0032355)	1/100	0.6348838	1.0000000	0	0	1.0000000	0.4543133	RAMP2
1209	fertilization (GO:0009566)	1/100	0.6348838	1.0000000	0	0	1.0000000	0.4543133	MEIOB
1210	organophosphate biosynthetic process (GO:0090407)	4/436	0.6373809	1.0000000	0	0	0.9174312	0.4131999	NPPC;RAMP2;PLA2G1B;QPRT
1211	negative regulation of cytoskeleton organization (GO:0051494)	1/101	0.6385533	1.0000000	0	0	0.9900990	0.4441090	DLC1
1212	regulation of response to cytokine stimulus (GO:0060759)	1/101	0.6385533	1.0000000	0	0	0.9900990	0.4441090	CCL5
1213	protein import (GO:0017038)	1/101	0.6385533	1.0000000	0	0	0.9900990	0.4441090	FGF9
1214	cellular response to decreased oxygen levels (GO:0036294)	1/101	0.6385533	1.0000000	0	0	0.9900990	0.4441090	KCNK3
1215	protein localization to nucleus (GO:0034504)	1/101	0.6385533	1.0000000	0	0	0.9900990	0.4441090	FGF9
1216	cellular component morphogenesis (GO:0032989)	4/437	0.6391657	1.0000000	0	0	0.9153318	0.4096948	GPM6A;GJA1;DMRT1;DCX
1217	positive regulation of neuron differentiation (GO:0045666)	2/217	0.6410868	1.0000000	0	0	0.9216590	0.4097607	ROBO2;FEZF2
1218	organic hydroxy compound transport (GO:0015850)	1/102	0.6421861	1.0000000	0	0	0.9803922	0.4341933	SLC5A7
1219	DNA catabolic process (GO:0006308)	1/102	0.6421861	1.0000000	0	0	0.9803922	0.4341933	MEIOB
1220	regulation of phosphatase activity (GO:0010921)	1/102	0.6421861	1.0000000	0	0	0.9803922	0.4341933	SLC7A14
1221	carbohydrate transport (GO:0008643)	1/102	0.6421861	1.0000000	0	0	0.9803922	0.4341933	PLA2G1B
1222	zymogen activation (GO:0031638)	1/102	0.6421861	1.0000000	0	0	0.9803922	0.4341933	DLC1
1223	peptidyl-tyrosine dephosphorylation (GO:0035335)	1/102	0.6421861	1.0000000	0	0	0.9803922	0.4341933	DUSP26
1224	immune response-activating signal transduction (GO:0002757)	4/440	0.6444860	1.0000000	0	0	0.9090909	0.3993656	IGHG4;TRAC;SKAP1;HLA-DQB2
1225	positive regulation of mitotic cell cycle (GO:0045931)	1/103	0.6457826	1.0000000	0	0	0.9708738	0.4245557	DMRT1
1226	regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains (GO:0002822)	1/103	0.6457826	1.0000000	0	0	0.9708738	0.4245557	HLA-DQB2
1227	positive regulation of lipid metabolic process (GO:0045834)	1/103	0.6457826	1.0000000	0	0	0.9708738	0.4245557	FABP3
1228	response to radiation (GO:0009314)	4/442	0.6480044	1.0000000	0	0	0.9049774	0.3926315	MFAP4;OPN1SW;GPC3;CNGA1
1229	antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)	1/104	0.6493431	1.0000000	0	0	0.9615385	0.4151866	CD207
1230	alcohol biosynthetic process (GO:0046165)	1/104	0.6493431	1.0000000	0	0	0.9615385	0.4151866	CH25H
1231	response to ketone (GO:1901654)	1/105	0.6528680	1.0000000	0	0	0.9523810	0.4060766	RAMP2
1232	negative regulation of endopeptidase activity (GO:0010951)	2/222	0.6533903	1.0000000	0	0	0.9009009	0.3834060	PROS1;A2ML1
1233	protein maturation (GO:0051604)	2/222	0.6533903	1.0000000	0	0	0.9009009	0.3834060	DLC1;SCG5
1234	membrane depolarization (GO:0051899)	1/106	0.6563576	1.0000000	0	0	0.9433962	0.3972165	GRIK1
1235	cellular amino acid biosynthetic process (GO:0008652)	1/106	0.6563576	1.0000000	0	0	0.9433962	0.3972165	PADI3
1236	regulation of cytokine secretion (GO:0050707)	1/106	0.6563576	1.0000000	0	0	0.9433962	0.3972165	CRTAM
1237	regulation of osteoblast differentiation (GO:0045667)	1/106	0.6563576	1.0000000	0	0	0.9433962	0.3972165	NPPC
1238	hematopoietic progenitor cell differentiation (GO:0002244)	1/106	0.6563576	1.0000000	0	0	0.9433962	0.3972165	APOBEC3H
1239	epithelial cell development (GO:0002064)	1/107	0.6598123	1.0000000	0	0	0.9345794	0.3885980	DMRT1
1240	positive regulation of JNK cascade (GO:0046330)	1/107	0.6598123	1.0000000	0	0	0.9345794	0.3885980	FLT4
1241	positive regulation of cell growth (GO:0030307)	1/107	0.6598123	1.0000000	0	0	0.9345794	0.3885980	ALOX12
1242	steroid biosynthetic process (GO:0006694)	1/108	0.6632325	1.0000000	0	0	0.9259259	0.3802127	CH25H
1243	maintenance of protein location (GO:0045185)	1/108	0.6632325	1.0000000	0	0	0.9259259	0.3802127	FBN1
1244	regulation of epithelial cell differentiation (GO:0030856)	1/109	0.6666184	1.0000000	0	0	0.9174312	0.3720527	ALOX12
1245	regulation of Ras protein signal transduction (GO:0046578)	1/109	0.6666184	1.0000000	0	0	0.9174312	0.3720527	DLC1
1246	response to ethanol (GO:0045471)	1/109	0.6666184	1.0000000	0	0	0.9174312	0.3720527	NPPC
1247	cellular response to oxygen levels (GO:0071453)	1/109	0.6666184	1.0000000	0	0	0.9174312	0.3720527	KCNK3
1248	axonogenesis (GO:0007409)	1/109	0.6666184	1.0000000	0	0	0.9174312	0.3720527	DCX
1249	cellular process involved in reproduction in multicellular organism (GO:0022412)	2/228	0.6677106	1.0000000	0	0	0.8771930	0.3542987	ROBO2;DMRT1
1250	regulation of leukocyte migration (GO:0002685)	1/110	0.6699705	1.0000000	0	0	0.9090909	0.3641106	CCL5
1251	cellular response to inorganic substance (GO:0071241)	1/110	0.6699705	1.0000000	0	0	0.9090909	0.3641106	KCNK3
1252	regulation of hormone levels (GO:0010817)	2/229	0.6700506	1.0000000	0	0	0.8733624	0.3496962	MC4R;SCG5
1253	response to tumor necrosis factor (GO:0034612)	1/111	0.6732890	1.0000000	0	0	0.9009009	0.3563789	CCL5
1254	regulation of peptide transport (GO:0090087)	2/231	0.6746907	1.0000000	0	0	0.8658009	0.3406934	KISS1;CCL5
1255	negative regulation of phosphorus metabolic process (GO:0010563)	4/458	0.6753226	1.0000000	0	0	0.8733624	0.3428513	GABBR2;CAMK2N1;SLC7A14;DUSP26
1256	negative regulation of phosphate metabolic process (GO:0045936)	4/458	0.6753226	1.0000000	0	0	0.8733624	0.3428513	GABBR2;CAMK2N1;SLC7A14;DUSP26
1257	regulation of mitosis (GO:0007088)	1/112	0.6765743	1.0000000	0	0	0.8928571	0.3488508	DMRT1
1258	cell activation involved in immune response (GO:0002263)	1/112	0.6765743	1.0000000	0	0	0.8928571	0.3488508	CX3CR1
1259	leukocyte activation involved in immune response (GO:0002366)	1/112	0.6765743	1.0000000	0	0	0.8928571	0.3488508	CX3CR1
1260	regulation of adaptive immune response (GO:0002819)	1/112	0.6765743	1.0000000	0	0	0.8928571	0.3488508	HLA-DQB2
1261	gonad development (GO:0008406)	1/112	0.6765743	1.0000000	0	0	0.8928571	0.3488508	FGF9
1262	regulation of cell shape (GO:0008360)	1/112	0.6765743	1.0000000	0	0	0.8928571	0.3488508	DLC1
1263	lipid catabolic process (GO:0016042)	2/232	0.6769910	1.0000000	0	0	0.8620690	0.3362908	ACOXL;PLA2G1B
1264	exocytosis (GO:0006887)	2/233	0.6792781	1.0000000	0	0	0.8583691	0.3319525	PROS1;CCL5
1265	peptide metabolic process (GO:0006518)	1/113	0.6798268	1.0000000	0	0	0.8849558	0.3415197	SCG5
1266	regulation of lipid biosynthetic process (GO:0046890)	1/113	0.6798268	1.0000000	0	0	0.8849558	0.3415197	FABP3
1267	protein-DNA complex assembly (GO:0065004)	1/113	0.6798268	1.0000000	0	0	0.8849558	0.3415197	NAP1L3
1268	regulation of cell division (GO:0051302)	2/234	0.6815520	1.0000000	0	0	0.8547009	0.3276775	DMRT1;FGF9
1269	double-strand break repair (GO:0006302)	1/114	0.6830467	1.0000000	0	0	0.8771930	0.3343790	MEIOB
1270	tube formation (GO:0035148)	1/114	0.6830467	1.0000000	0	0	0.8771930	0.3343790	DLC1
1271	regulation of axonogenesis (GO:0050770)	1/114	0.6830467	1.0000000	0	0	0.8771930	0.3343790	ROBO2
1272	positive regulation of lymphocyte proliferation (GO:0050671)	1/115	0.6862344	1.0000000	0	0	0.8695652	0.3274226	CCL5
1273	Fc receptor signaling pathway (GO:0038093)	3/352	0.6867026	1.0000000	0	0	0.8522727	0.3203301	IGHG4;FGF9;FGF18
1274	negative regulation of organelle organization (GO:0010639)	2/237	0.6882952	1.0000000	0	0	0.8438819	0.3152215	DMRT1;DLC1
1275	extracellular matrix disassembly (GO:0022617)	1/116	0.6893902	1.0000000	0	0	0.8620690	0.3206447	FBN1
1276	positive regulation of mononuclear cell proliferation (GO:0032946)	1/116	0.6893902	1.0000000	0	0	0.8620690	0.3206447	CCL5
1277	response to UV (GO:0009411)	1/117	0.6925144	1.0000000	0	0	0.8547009	0.3140395	MFAP4
1278	steroid metabolic process (GO:0008202)	2/240	0.6949213	1.0000000	0	0	0.8333333	0.3032972	CH25H;LEPR
1279	positive regulation of stress-activated MAPK cascade (GO:0032874)	1/118	0.6956073	1.0000000	0	0	0.8474576	0.3076017	FLT4
1280	regulation of DNA replication (GO:0006275)	1/118	0.6956073	1.0000000	0	0	0.8474576	0.3076017	PLA2G1B
1281	cell maturation (GO:0048469)	1/118	0.6956073	1.0000000	0	0	0.8474576	0.3076017	GJA1
1282	embryonic organ development (GO:0048568)	1/119	0.6986693	1.0000000	0	0	0.8403361	0.3013258	FGF9
1283	positive regulation of leukocyte proliferation (GO:0070665)	1/119	0.6986693	1.0000000	0	0	0.8403361	0.3013258	CCL5
1284	positive regulation of stress-activated protein kinase signaling cascade (GO:0070304)	1/119	0.6986693	1.0000000	0	0	0.8403361	0.3013258	FLT4
1285	epidermis development (GO:0008544)	1/120	0.7017006	1.0000000	0	0	0.8333333	0.2952070	EMP1
1286	nucleosome organization (GO:0034728)	1/120	0.7017006	1.0000000	0	0	0.8333333	0.2952070	NAP1L3
1287	regulation of cell projection assembly (GO:0060491)	1/120	0.7017006	1.0000000	0	0	0.8333333	0.2952070	GPM6A
1288	transition metal ion homeostasis (GO:0055076)	1/120	0.7017006	1.0000000	0	0	0.8333333	0.2952070	ABCG2
1289	negative regulation of defense response (GO:0031348)	1/120	0.7017006	1.0000000	0	0	0.8333333	0.2952070	IFIT1
1290	plasma membrane organization (GO:0007009)	1/121	0.7047016	1.0000000	0	0	0.8264463	0.2892403	RAMP2
1291	neuron development (GO:0048666)	1/121	0.7047016	1.0000000	0	0	0.8264463	0.2892403	ROBO2
1292	germ cell development (GO:0007281)	1/121	0.7047016	1.0000000	0	0	0.8264463	0.2892403	DMRT1
1293	response to temperature stimulus (GO:0009266)	1/122	0.7076726	1.0000000	0	0	0.8196721	0.2834211	STAC
1294	adenylate cyclase-modulating G-protein coupled receptor signaling pathway (GO:0007188)	1/122	0.7076726	1.0000000	0	0	0.8196721	0.2834211	MC4R
1295	regulation of gene expression, epigenetic (GO:0040029)	1/122	0.7076726	1.0000000	0	0	0.8196721	0.2834211	APOBEC2
1296	vitamin metabolic process (GO:0006766)	1/122	0.7076726	1.0000000	0	0	0.8196721	0.2834211	QPRT
1297	regulation of muscle cell differentiation (GO:0051147)	1/122	0.7076726	1.0000000	0	0	0.8196721	0.2834211	HOPX
1298	regionalization (GO:0003002)	2/247	0.7099322	1.0000000	0	0	0.8097166	0.2773974	HHIP;FEZF2
1299	cellular response to steroid hormone stimulus (GO:0071383)	1/123	0.7106138	1.0000000	0	0	0.8130081	0.2777449	OR51E2
1300	ameboidal-type cell migration (GO:0001667)	1/123	0.7106138	1.0000000	0	0	0.8130081	0.2777449	GPR124
1301	positive regulation of cell morphogenesis involved in differentiation (GO:0010770)	1/123	0.7106138	1.0000000	0	0	0.8130081	0.2777449	ROBO2
1302	regulation of lymphocyte differentiation (GO:0045619)	1/124	0.7135255	1.0000000	0	0	0.8064516	0.2722073	HLA-DOA
1303	mucopolysaccharide metabolic process (GO:1903510)	1/124	0.7135255	1.0000000	0	0	0.8064516	0.2722073	GPC3
1304	positive regulation of DNA metabolic process (GO:0051054)	1/124	0.7135255	1.0000000	0	0	0.8064516	0.2722073	PLA2G1B
1305	neuron projection guidance (GO:0097485)	3/367	0.7135377	1.0000000	0	0	0.8174387	0.2759019	ROBO2;DCX;FEZF2
1306	axon guidance (GO:0007411)	3/367	0.7135377	1.0000000	0	0	0.8174387	0.2759019	ROBO2;DCX;FEZF2
1307	phosphatidylinositol metabolic process (GO:0046488)	1/125	0.7164081	1.0000000	0	0	0.8000000	0.2668042	PLA2G1B
1308	positive regulation of NF-kappaB transcription factor activity (GO:0051092)	1/126	0.7192619	1.0000000	0	0	0.7936508	0.2615316	PLA2G1B
1309	activation of immune response (GO:0002253)	4/487	0.7210317	1.0000000	0	0	0.8213552	0.2686424	IGHG4;TRAC;SKAP1;HLA-DQB2
1310	circadian rhythm (GO:0007623)	1/127	0.7220870	1.0000000	0	0	0.7874016	0.2563855	DDC
1311	cofactor biosynthetic process (GO:0051188)	1/127	0.7220870	1.0000000	0	0	0.7874016	0.2563855	QPRT
1312	actin cytoskeleton organization (GO:0030036)	2/253	0.7223054	1.0000000	0	0	0.7905138	0.2571598	DLC1;MYOZ1
1313	calcium ion transmembrane transport (GO:0070588)	1/128	0.7248839	1.0000000	0	0	0.7812500	0.2513623	GPM6A
1314	response to metal ion (GO:0010038)	2/255	0.7263303	1.0000000	0	0	0.7843137	0.2507846	KCNK3;ABCG2
1315	generation of precursor metabolites and energy (GO:0006091)	3/375	0.7271132	1.0000000	0	0	0.8000000	0.2549385	MC4R;LEPR;RUNX1T1
1316	inflammatory response (GO:0006954)	3/376	0.7287745	1.0000000	0	0	0.7978723	0.2524396	GJA1;SCUBE1;CCL5
1317	positive regulation of protein serine/threonine kinase activity (GO:0071902)	2/257	0.7303060	1.0000000	0	0	0.7782101	0.2445850	PLA2G1B;DIRAS2
1318	positive regulation of response to wounding (GO:1903036)	1/130	0.7303939	1.0000000	0	0	0.7692308	0.2416702	HOPX
1319	negative regulation of MAPK cascade (GO:0043409)	1/130	0.7303939	1.0000000	0	0	0.7692308	0.2416702	DUSP26
1320	carbohydrate derivative biosynthetic process (GO:1901137)	3/377	0.7304279	1.0000000	0	0	0.7957560	0.2499667	NPPC;RAMP2;GPC3
1321	cellular lipid catabolic process (GO:0044242)	1/131	0.7331076	1.0000000	0	0	0.7633588	0.2369945	ACOXL
1322	regulation of protein transport (GO:0051223)	3/379	0.7337111	1.0000000	0	0	0.7915567	0.2450976	PLA2G1B;CRTAM;OR51E2
1323	signal transduction by p53 class mediator (GO:0072331)	1/132	0.7357941	1.0000000	0	0	0.7575758	0.2324280	ZNF385B
1324	negative regulation of protein phosphorylation (GO:0001933)	2/260	0.7361780	1.0000000	0	0	0.7692308	0.2356026	CAMK2N1;DUSP26
1325	regulation of protein catabolic process (GO:0042176)	2/260	0.7361780	1.0000000	0	0	0.7692308	0.2356026	GJA1;GPC3
1326	small molecule catabolic process (GO:0044282)	2/261	0.7381112	1.0000000	0	0	0.7662835	0.2326903	ACOXL;QPRT
1327	activation of MAPK activity (GO:0000187)	1/133	0.7384537	1.0000000	0	0	0.7518797	0.2279676	PLA2G1B
1328	humoral immune response (GO:0006959)	2/263	0.7419414	1.0000000	0	0	0.7604563	0.2269848	IGHG4;PLA2G1B
1329	pattern specification process (GO:0007389)	3/385	0.7433729	1.0000000	0	0	0.7792208	0.2310837	HHIP;GPC3;FEZF2
1330	reproductive structure development (GO:0048608)	2/265	0.7457238	1.0000000	0	0	0.7547170	0.2214339	FGF9;PEG10
1331	protein-DNA complex subunit organization (GO:0071824)	1/136	0.7462737	1.0000000	0	0	0.7352941	0.2151933	NAP1L3
1332	regulation of cellular carbohydrate metabolic process (GO:0010675)	1/137	0.7488283	1.0000000	0	0	0.7299270	0.2111281	LEPR
1333	neuron projection development (GO:0031175)	1/137	0.7488283	1.0000000	0	0	0.7299270	0.2111281	FEZF2
1334	regulation of ion transmembrane transporter activity (GO:0032412)	1/137	0.7488283	1.0000000	0	0	0.7299270	0.2111281	KCNJ1
1335	regulation of nuclear division (GO:0051783)	1/138	0.7513574	1.0000000	0	0	0.7246377	0.2071550	DMRT1
1336	positive regulation of peptidyl-tyrosine phosphorylation (GO:0050731)	1/139	0.7538610	1.0000000	0	0	0.7194245	0.2032714	CCL5
1337	regulation of heart contraction (GO:0008016)	1/140	0.7563396	1.0000000	0	0	0.7142857	0.1994748	HOPX
1338	regulation of transmembrane transporter activity (GO:0022898)	1/141	0.7587934	1.0000000	0	0	0.7092199	0.1957629	KCNJ1
1339	response to reactive oxygen species (GO:0000302)	1/141	0.7587934	1.0000000	0	0	0.7092199	0.1957629	SCGB1A1
1340	regulation of MAP kinase activity (GO:0043405)	2/273	0.7603837	1.0000000	0	0	0.7326007	0.2006829	PLA2G1B;DIRAS2
1341	response to alcohol (GO:0097305)	2/274	0.7621641	1.0000000	0	0	0.7299270	0.1982434	NPPC;RAMP2
1342	neurotrophin TRK receptor signaling pathway (GO:0048011)	2/274	0.7621641	1.0000000	0	0	0.7299270	0.1982434	FGF9;FGF18
1343	positive regulation of neuron projection development (GO:0010976)	1/144	0.7660082	1.0000000	0	0	0.6944444	0.1851128	ROBO2
1344	regulation of carbohydrate metabolic process (GO:0006109)	1/145	0.7683650	1.0000000	0	0	0.6896552	0.1817175	LEPR
1345	neurotrophin signaling pathway (GO:0038179)	2/278	0.7691720	1.0000000	0	0	0.7194245	0.1888062	FGF9;FGF18
1346	organ morphogenesis (GO:0009887)	3/405	0.7735836	1.0000000	0	0	0.7407407	0.1901641	HHIP;DLC1;TBX4
1347	regulation of JNK cascade (GO:0046328)	1/148	0.7752949	1.0000000	0	0	0.6756757	0.1719675	FLT4
1348	positive regulation of Rho GTPase activity (GO:0032321)	1/149	0.7775586	1.0000000	0	0	0.6711409	0.1688565	DLC1
1349	positive regulation of neurogenesis (GO:0050769)	2/283	0.7776798	1.0000000	0	0	0.7067138	0.1776964	ROBO2;FEZF2
1350	negative regulation of transferase activity (GO:0051348)	2/284	0.7793483	1.0000000	0	0	0.7042254	0.1755614	CAMK2N1;DUSP26
1351	actin filament organization (GO:0007015)	1/150	0.7797997	1.0000000	0	0	0.6666667	0.1658121	PLA2G1B
1352	anterior/posterior pattern specification (GO:0009952)	1/150	0.7797997	1.0000000	0	0	0.6666667	0.1658121	FEZF2
1353	negative regulation of cell growth (GO:0030308)	1/150	0.7797997	1.0000000	0	0	0.6666667	0.1658121	SCGB3A1
1354	peptidyl-tyrosine phosphorylation (GO:0018108)	1/152	0.7842147	1.0000000	0	0	0.6578947	0.1599160	FLT4
1355	maintenance of location (GO:0051235)	1/152	0.7842147	1.0000000	0	0	0.6578947	0.1599160	FBN1
1356	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger (GO:0007187)	1/153	0.7863891	1.0000000	0	0	0.6535948	0.1570612	MC4R
1357	regulation of transporter activity (GO:0032409)	1/153	0.7863891	1.0000000	0	0	0.6535948	0.1570612	KCNJ1
1358	myeloid cell differentiation (GO:0030099)	1/154	0.7885417	1.0000000	0	0	0.6493506	0.1542663	GPC3
1359	developmental maturation (GO:0021700)	1/154	0.7885417	1.0000000	0	0	0.6493506	0.1542663	GJA1
1360	peptidyl-tyrosine modification (GO:0018212)	1/154	0.7885417	1.0000000	0	0	0.6493506	0.1542663	FLT4
1361	cellular amino acid metabolic process (GO:0006520)	3/421	0.7956155	1.0000000	0	0	0.7125891	0.1629258	DDC;PLA2G1B;PADI3
1362	hormone metabolic process (GO:0042445)	1/158	0.7969382	1.0000000	0	0	0.6329114	0.1436570	SCG5
1363	Fc-epsilon receptor signaling pathway (GO:0038095)	2/295	0.7969918	1.0000000	0	0	0.6779661	0.1538379	FGF9;FGF18
1364	regulation of extrinsic apoptotic signaling pathway (GO:2001236)	1/161	0.8030171	1.0000000	0	0	0.6211180	0.1362604	CX3CR1
1365	protein dephosphorylation (GO:0006470)	1/161	0.8030171	1.0000000	0	0	0.6211180	0.1362604	DUSP26
1366	complement activation, classical pathway (GO:0006958)	1/162	0.8050029	1.0000000	0	0	0.6172840	0.1338947	IGHG4
1367	glycosaminoglycan metabolic process (GO:0030203)	1/162	0.8050029	1.0000000	0	0	0.6172840	0.1338947	GPC3
1368	response to nutrient (GO:0007584)	1/163	0.8069688	1.0000000	0	0	0.6134969	0.1315768	ABCG2
1369	actin filament-based process (GO:0030029)	2/303	0.8090320	1.0000000	0	0	0.6600660	0.1398791	DLC1;MYOZ1
1370	cellular response to transforming growth factor beta stimulus (GO:0071560)	1/166	0.8127489	1.0000000	0	0	0.6024096	0.1248994	CX3CR1
1371	response to estrogen (GO:0043627)	1/166	0.8127489	1.0000000	0	0	0.6024096	0.1248994	RAMP2
1372	response to transforming growth factor beta (GO:0071559)	1/166	0.8127489	1.0000000	0	0	0.6024096	0.1248994	CX3CR1
1373	regulation of vesicle-mediated transport (GO:0060627)	2/306	0.8133814	1.0000000	0	0	0.6535948	0.1350034	SFTPD;GPC3
1374	response to wounding (GO:0009611)	1/167	0.8146371	1.0000000	0	0	0.5988024	0.1227620	CX3CR1
1375	establishment of organelle localization (GO:0051656)	1/168	0.8165063	1.0000000	0	0	0.5952381	0.1206671	DDC
1376	positive regulation of I-kappaB kinase/NF-kappaB signaling (GO:0043123)	1/168	0.8165063	1.0000000	0	0	0.5952381	0.1206671	GJA1
1377	regulation of insulin secretion (GO:0050796)	1/169	0.8183568	1.0000000	0	0	0.5917160	0.1186135	CCL5
1378	regulation of stress-activated MAPK cascade (GO:0032872)	1/170	0.8201887	1.0000000	0	0	0.5882353	0.1166005	FLT4
1379	protein autophosphorylation (GO:0046777)	1/170	0.8201887	1.0000000	0	0	0.5882353	0.1166005	FLT4
1380	intrinsic apoptotic signaling pathway (GO:0097193)	1/170	0.8201887	1.0000000	0	0	0.5882353	0.1166005	ZNF385B
1381	regulation of establishment of protein localization (GO:0070201)	3/442	0.8218049	1.0000000	0	0	0.6787330	0.1332029	PLA2G1B;CRTAM;OR51E2
1382	aminoglycan metabolic process (GO:0006022)	1/171	0.8220022	1.0000000	0	0	0.5847953	0.1146270	GPC3
1383	regulation of stress-activated protein kinase signaling cascade (GO:0070302)	1/171	0.8220022	1.0000000	0	0	0.5847953	0.1146270	FLT4
1384	positive regulation of nervous system development (GO:0051962)	2/313	0.8231892	1.0000000	0	0	0.6389776	0.1243253	ROBO2;FEZF2
1385	regulation of Rho GTPase activity (GO:0032319)	1/174	0.8273342	1.0000000	0	0	0.5747126	0.1089348	DLC1
1386	complement activation (GO:0006956)	1/175	0.8290760	1.0000000	0	0	0.5714286	0.1071105	IGHG4
1387	response to mechanical stimulus (GO:0009612)	1/176	0.8308003	1.0000000	0	0	0.5681818	0.1053215	GJA1
1388	cellular amide metabolic process (GO:0043603)	1/177	0.8325073	1.0000000	0	0	0.5649718	0.1035668	SCG5
1389	glycerophospholipid biosynthetic process (GO:0046474)	1/178	0.8341972	1.0000000	0	0	0.5617978	0.1018458	PLA2G1B
1390	regulation of cell growth (GO:0001558)	2/322	0.8351215	1.0000000	0	0	0.6211180	0.1119119	SCGB3A1;ALOX12
1391	nucleobase-containing compound transport (GO:0015931)	1/180	0.8375262	1.0000000	0	0	0.5555556	0.0985015	GJA1
1392	positive regulation of protein kinase activity (GO:0045860)	3/456	0.8376406	1.0000000	0	0	0.6578947	0.1165566	PLA2G1B;CCL5;DIRAS2
1393	negative regulation of phosphorylation (GO:0042326)	2/325	0.8389352	1.0000000	0	0	0.6153846	0.1080750	CAMK2N1;DUSP26
1394	ATP catabolic process (GO:0006200)	2/327	0.8414333	1.0000000	0	0	0.6116208	0.1055954	KIF12;ABCG2
1395	positive regulation of cytokine production (GO:0001819)	2/327	0.8414333	1.0000000	0	0	0.6116208	0.1055954	FLT4;CRTAM
1396	cellular response to external stimulus (GO:0071496)	1/185	0.8455606	1.0000000	0	0	0.5405405	0.0906786	GJA1
1397	cellular component assembly involved in morphogenesis (GO:0010927)	1/186	0.8471194	1.0000000	0	0	0.5376344	0.0892009	MYOZ1
1398	ribonucleoside monophosphate catabolic process (GO:0009158)	2/332	0.8475264	1.0000000	0	0	0.6024096	0.0996586	KIF12;ABCG2
1399	purine ribonucleoside monophosphate catabolic process (GO:0009169)	2/332	0.8475264	1.0000000	0	0	0.6024096	0.0996586	KIF12;ABCG2
1400	microtubule-based movement (GO:0007018)	1/187	0.8486625	1.0000000	0	0	0.5347594	0.0877506	KIF12
1401	negative regulation of apoptotic signaling pathway (GO:2001234)	1/187	0.8486625	1.0000000	0	0	0.5347594	0.0877506	CX3CR1
1402	purine nucleoside monophosphate catabolic process (GO:0009128)	2/333	0.8487194	1.0000000	0	0	0.6006006	0.0985145	KIF12;ABCG2
1403	nucleoside monophosphate catabolic process (GO:0009125)	2/335	0.8510799	1.0000000	0	0	0.5970149	0.0962682	KIF12;ABCG2
1404	regulation of peptidyl-tyrosine phosphorylation (GO:0050730)	1/189	0.8517025	1.0000000	0	0	0.5291005	0.0849302	CCL5
1405	coagulation (GO:0050817)	3/472	0.8542469	1.0000000	0	0	0.6355932	0.1001282	SCUBE1;PROS1;JAM2
1406	blood coagulation (GO:0007596)	3/472	0.8542469	1.0000000	0	0	0.6355932	0.1001282	SCUBE1;PROS1;JAM2
1407	regulation of sequence-specific DNA binding transcription factor activity (GO:0051090)	2/338	0.8545582	1.0000000	0	0	0.5917160	0.0930004	BEX1;PLA2G1B
1408	negative regulation of cellular component organization (GO:0051129)	3/474	0.8562155	1.0000000	0	0	0.6329114	0.0982488	ROBO2;DMRT1;DLC1
1409	hemostasis (GO:0007599)	3/478	0.8600836	1.0000000	0	0	0.6276151	0.0945977	SCUBE1;PROS1;JAM2
1410	muscle contraction (GO:0006936)	1/195	0.8604625	1.0000000	0	0	0.5128205	0.0770693	GJA1
1411	DNA recombination (GO:0006310)	1/196	0.8618716	1.0000000	0	0	0.5102041	0.0758413	MEIOB
1412	protein activation cascade (GO:0072376)	1/196	0.8618716	1.0000000	0	0	0.5102041	0.0758413	IGHG4
1413	coenzyme metabolic process (GO:0006732)	1/196	0.8618716	1.0000000	0	0	0.5102041	0.0758413	QPRT
1414	positive regulation of kinase activity (GO:0033674)	3/480	0.8619834	1.0000000	0	0	0.6250000	0.0928245	PLA2G1B;CCL5;DIRAS2
1415	negative regulation of intracellular signal transduction (GO:1902532)	2/345	0.8623889	1.0000000	0	0	0.5797101	0.0858254	DLC1;DUSP26
1416	positive regulation of response to external stimulus (GO:0032103)	1/201	0.8687075	1.0000000	0	0	0.4975124	0.0700243	CCL5
1417	glycerolipid biosynthetic process (GO:0045017)	1/202	0.8700337	1.0000000	0	0	0.4950495	0.0689224	PLA2G1B
1418	immune response-regulating cell surface receptor signaling pathway involved in phagocytosis (GO:0002433)	1/203	0.8713466	1.0000000	0	0	0.4926108	0.0678401	IGHG4
1419	Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096)	1/203	0.8713466	1.0000000	0	0	0.4926108	0.0678401	IGHG4
1420	Fc-gamma receptor signaling pathway (GO:0038094)	1/203	0.8713466	1.0000000	0	0	0.4926108	0.0678401	IGHG4
1421	lipid biosynthetic process (GO:0008610)	3/491	0.8720349	1.0000000	0	0	0.6109980	0.0836614	CH25H;PLA2G1B;ALOX12
1422	cell morphogenesis (GO:0000902)	1/204	0.8726464	1.0000000	0	0	0.4901961	0.0667769	DMRT1
1423	nucleocytoplasmic transport (GO:0006913)	1/204	0.8726464	1.0000000	0	0	0.4901961	0.0667769	FGF9
1424	Fc receptor mediated stimulatory signaling pathway (GO:0002431)	1/204	0.8726464	1.0000000	0	0	0.4901961	0.0667769	IGHG4
1425	chromosome organization (GO:0051276)	1/204	0.8726464	1.0000000	0	0	0.4901961	0.0667769	MEIOB
1426	platelet activation (GO:0030168)	1/205	0.8739330	1.0000000	0	0	0.4878049	0.0657325	PROS1
1427	phospholipid biosynthetic process (GO:0008654)	1/206	0.8752067	1.0000000	0	0	0.4854369	0.0647064	PLA2G1B
1428	positive regulation of cell development (GO:0010720)	2/358	0.8759198	1.0000000	0	0	0.5586592	0.0740116	ROBO2;FEZF2
1429	nuclear transport (GO:0051169)	1/209	0.8789515	1.0000000	0	0	0.4784689	0.0617347	FGF9
1430	single-organism behavior (GO:0044708)	2/362	0.8798311	1.0000000	0	0	0.5524862	0.0707322	SNCG;GRIK1
1431	regulation of leukocyte differentiation (GO:1902105)	1/210	0.8801748	1.0000000	0	0	0.4761905	0.0607785	HLA-DOA
1432	post-translational protein modification (GO:0043687)	1/211	0.8813857	1.0000000	0	0	0.4739336	0.0598388	PROS1
1433	negative regulation of nervous system development (GO:0051961)	1/211	0.8813857	1.0000000	0	0	0.4739336	0.0598388	ROBO2
1434	regulation of I-kappaB kinase/NF-kappaB signaling (GO:0043122)	1/213	0.8837712	1.0000000	0	0	0.4694836	0.0580080	GJA1
1435	alpha-amino acid metabolic process (GO:1901605)	1/213	0.8837712	1.0000000	0	0	0.4694836	0.0580080	PADI3
1436	positive regulation of intracellular transport (GO:0032388)	1/217	0.8883999	1.0000000	0	0	0.4608295	0.0545315	PLA2G1B
1437	positive regulation of cell cycle process (GO:0090068)	1/220	0.8917506	1.0000000	0	0	0.4545455	0.0520767	DMRT1
1438	ATP metabolic process (GO:0046034)	2/377	0.8935096	1.0000000	0	0	0.5305040	0.0597338	KIF12;ABCG2
1439	in utero embryonic development (GO:0001701)	1/222	0.8939287	1.0000000	0	0	0.4504505	0.0505087	GJA1
1440	regulation of neuron death (GO:1901214)	1/225	0.8971142	1.0000000	0	0	0.4444444	0.0482543	CCL5
1441	chordate embryonic development (GO:0043009)	1/226	0.8981547	1.0000000	0	0	0.4424779	0.0475278	GJA1
1442	cognition (GO:0050890)	1/227	0.8991848	1.0000000	0	0	0.4405286	0.0468135	TMPRSS11E
1443	glycerophospholipid metabolic process (GO:0006650)	1/229	0.9012140	1.0000000	0	0	0.4366812	0.0454203	PLA2G1B
1444	embryo development ending in birth or egg hatching (GO:0009792)	1/230	0.9022132	1.0000000	0	0	0.4347826	0.0447410	GJA1
1445	nucleic acid phosphodiester bond hydrolysis (GO:0090305)	1/230	0.9022132	1.0000000	0	0	0.4347826	0.0447410	MEIOB
1446	regulation of anatomical structure size (GO:0090066)	1/232	0.9041817	1.0000000	0	0	0.4310345	0.0434159	NPPC
1447	regulation of cell projection organization (GO:0031344)	2/391	0.9049630	1.0000000	0	0	0.5115090	0.0510799	ROBO2;GPM6A
1448	muscle system process (GO:0003012)	1/237	0.9089322	1.0000000	0	0	0.4219409	0.0402890	GJA1
1449	negative regulation of cell development (GO:0010721)	1/239	0.9107660	1.0000000	0	0	0.4184100	0.0391085	NPPC
1450	regulation of actin cytoskeleton organization (GO:0032956)	1/240	0.9116691	1.0000000	0	0	0.4166667	0.0385326	DLC1
1451	purine ribonucleoside monophosphate metabolic process (GO:0009167)	2/402	0.9131472	1.0000000	0	0	0.4975124	0.0452031	KIF12;ABCG2
1452	purine nucleoside monophosphate metabolic process (GO:0009126)	2/403	0.9138576	1.0000000	0	0	0.4962779	0.0447050	KIF12;ABCG2
1453	GTP catabolic process (GO:0006184)	1/243	0.9143243	1.0000000	0	0	0.4115226	0.0368601	DIRAS2
1454	regulation of neuron differentiation (GO:0045664)	2/405	0.9152623	1.0000000	0	0	0.4938272	0.0437257	ROBO2;FEZF2
1455	regulation of lipid metabolic process (GO:0019216)	1/245	0.9160501	1.0000000	0	0	0.4081633	0.0357895	FABP3
1456	negative regulation of protein modification process (GO:0031400)	2/407	0.9166456	1.0000000	0	0	0.4914005	0.0427687	CAMK2N1;DUSP26
1457	guanosine-containing compound catabolic process (GO:1901069)	1/246	0.9169000	1.0000000	0	0	0.4065041	0.0352670	DIRAS2
1458	regulation of cell morphogenesis (GO:0022604)	2/408	0.9173293	1.0000000	0	0	0.4901961	0.0422984	ROBO2;DLC1
1459	regulation of cell morphogenesis involved in differentiation (GO:0010769)	1/248	0.9185742	1.0000000	0	0	0.4032258	0.0342470	ROBO2
1460	positive regulation of cellular component biogenesis (GO:0044089)	1/249	0.9193986	1.0000000	0	0	0.4016064	0.0337492	GPM6A
1461	leukocyte differentiation (GO:0002521)	1/251	0.9210227	1.0000000	0	0	0.3984064	0.0327771	GPC3
1462	activation of protein kinase activity (GO:0032147)	1/252	0.9218225	1.0000000	0	0	0.3968254	0.0323026	PLA2G1B
1463	ribonucleoside monophosphate metabolic process (GO:0009161)	2/416	0.9226129	1.0000000	0	0	0.4807692	0.0387238	KIF12;ABCG2
1464	regulation of protein serine/threonine kinase activity (GO:0071900)	2/416	0.9226129	1.0000000	0	0	0.4807692	0.0387238	PLA2G1B;DIRAS2
1465	negative regulation of cell cycle process (GO:0010948)	1/254	0.9233980	1.0000000	0	0	0.3937008	0.0313760	DMRT1
1466	cofactor metabolic process (GO:0051186)	1/255	0.9241738	1.0000000	0	0	0.3921569	0.0309236	QPRT
1467	cellular protein complex assembly (GO:0043623)	1/256	0.9249419	1.0000000	0	0	0.3906250	0.0304783	CCL5
1468	regulation of small GTPase mediated signal transduction (GO:0051056)	1/256	0.9249419	1.0000000	0	0	0.3906250	0.0304783	DLC1
1469	regulation of actin filament-based process (GO:0032970)	1/257	0.9257022	1.0000000	0	0	0.3891051	0.0300400	DLC1
1470	GTP metabolic process (GO:0046039)	1/258	0.9264548	1.0000000	0	0	0.3875969	0.0296085	DIRAS2
1471	nucleoside monophosphate metabolic process (GO:0009123)	2/427	0.9293624	1.0000000	0	0	0.4683841	0.0343122	KIF12;ABCG2
1472	regulation of translation (GO:0006417)	1/264	0.9308139	1.0000000	0	0	0.3787879	0.0271575	CCL5
1473	protein glycosylation (GO:0006486)	1/264	0.9308139	1.0000000	0	0	0.3787879	0.0271575	ST6GAL2
1474	macromolecule glycosylation (GO:0043413)	1/264	0.9308139	1.0000000	0	0	0.3787879	0.0271575	ST6GAL2
1475	negative regulation of cell cycle (GO:0045786)	2/430	0.9311049	1.0000000	0	0	0.4651163	0.0332016	NPPC;DMRT1
1476	guanosine-containing compound metabolic process (GO:1901068)	1/269	0.9342494	1.0000000	0	0	0.3717472	0.0252832	DIRAS2
1477	posttranscriptional regulation of gene expression (GO:0010608)	2/438	0.9355556	1.0000000	0	0	0.4566210	0.0304177	CCL5;SCGB1A1
1478	small GTPase mediated signal transduction (GO:0007264)	2/439	0.9360924	1.0000000	0	0	0.4555809	0.0300870	DLC1;DIRAS2
1479	glycosylation (GO:0070085)	1/273	0.9368751	1.0000000	0	0	0.3663004	0.0238847	ST6GAL2
1480	regulation of neuron projection development (GO:0010975)	1/275	0.9381486	1.0000000	0	0	0.3636364	0.0232171	ROBO2
1481	embryo development (GO:0009790)	1/276	0.9387757	1.0000000	0	0	0.3623188	0.0228908	GJA1
1482	protein localization to membrane (GO:0072657)	1/276	0.9387757	1.0000000	0	0	0.3623188	0.0228908	RAMP2
1483	organelle assembly (GO:0070925)	1/278	0.9400110	1.0000000	0	0	0.3597122	0.0222531	MYOZ1
1484	positive regulation of cell cycle (GO:0045787)	1/278	0.9400110	1.0000000	0	0	0.3597122	0.0222531	DMRT1
1485	dephosphorylation (GO:0016311)	1/278	0.9400110	1.0000000	0	0	0.3597122	0.0222531	DUSP26
1486	sensory perception (GO:0007600)	2/457	0.9450631	1.0000000	0	0	0.4376368	0.0247281	OPN1SW;CNGA1
1487	phospholipid metabolic process (GO:0006644)	1/288	0.9458253	1.0000000	0	0	0.3472222	0.0193394	PLA2G1B
1488	response to oxidative stress (GO:0006979)	1/290	0.9469190	1.0000000	0	0	0.3448276	0.0188075	SCGB1A1
1489	response to nutrient levels (GO:0031667)	1/291	0.9474576	1.0000000	0	0	0.3436426	0.0185474	ABCG2
1490	establishment of protein localization to organelle (GO:0072594)	1/292	0.9479908	1.0000000	0	0	0.3424658	0.0182913	FGF9
1491	positive regulation of Ras GTPase activity (GO:0032320)	1/292	0.9479908	1.0000000	0	0	0.3424658	0.0182913	DLC1
1492	histone modification (GO:0016570)	1/293	0.9485186	1.0000000	0	0	0.3412969	0.0180389	HOPX
1493	covalent chromatin modification (GO:0016569)	1/296	0.9500701	1.0000000	0	0	0.3378378	0.0173039	HOPX
1494	glycerolipid metabolic process (GO:0046486)	1/296	0.9500701	1.0000000	0	0	0.3378378	0.0173039	PLA2G1B
1495	nuclear division (GO:0000280)	1/298	0.9510786	1.0000000	0	0	0.3355705	0.0168317	MEIOB
1496	response to extracellular stimulus (GO:0009991)	1/313	0.9580230	1.0000000	0	0	0.3194888	0.0137008	ABCG2
1497	sulfur compound metabolic process (GO:0006790)	1/314	0.9584494	1.0000000	0	0	0.3184713	0.0135154	GPC3
1498	multicellular organismal reproductive process (GO:0048609)	2/491	0.9588501	1.0000000	0	0	0.4073320	0.0171163	DMRT1;ABCG2
1499	single-organism cellular localization (GO:1902580)	2/496	0.9605755	1.0000000	0	0	0.4032258	0.0162188	RAMP2;FGF9
1500	organelle fission (GO:0048285)	1/325	0.9628649	1.0000000	0	0	0.3076923	0.0116437	MEIOB
1501	apoptotic signaling pathway (GO:0097190)	1/327	0.9636160	1.0000000	0	0	0.3058104	0.0113341	ZNF385B
1502	positive regulation of organelle organization (GO:0010638)	1/340	0.9681429	1.0000000	0	0	0.2941176	0.0095222	DMRT1
1503	regulation of Ras GTPase activity (GO:0032318)	1/349	0.9709441	1.0000000	0	0	0.2865330	0.0084488	DLC1
1504	regulation of cytoskeleton organization (GO:0051493)	1/350	0.9712398	1.0000000	0	0	0.2857143	0.0083377	DLC1
1505	cellular component disassembly (GO:0022411)	1/350	0.9712398	1.0000000	0	0	0.2857143	0.0083377	FBN1
1506	spermatogenesis (GO:0007283)	1/353	0.9721090	1.0000000	0	0	0.2832861	0.0080134	DMRT1
1507	male gamete generation (GO:0048232)	1/354	0.9723929	1.0000000	0	0	0.2824859	0.0079083	DMRT1
1508	regulation of apoptotic signaling pathway (GO:2001233)	1/356	0.9729521	1.0000000	0	0	0.2808989	0.0077024	CX3CR1
1509	gamete generation (GO:0007276)	1/390	0.9809052	1.0000000	0	0	0.2564103	0.0049435	DMRT1
1510	regulation of mitotic cell cycle (GO:0007346)	1/391	0.9810999	1.0000000	0	0	0.2557545	0.0048800	DMRT1
1511	regulation of intracellular transport (GO:0032386)	1/394	0.9816723	1.0000000	0	0	0.2538071	0.0046949	PLA2G1B
1512	protein localization to organelle (GO:0033365)	1/396	0.9820443	1.0000000	0	0	0.2525253	0.0045755	FGF9
1513	mRNA processing (GO:0006397)	1/397	0.9822274	1.0000000	0	0	0.2518892	0.0045170	APOBEC2
1514	DNA repair (GO:0006281)	1/403	0.9832880	1.0000000	0	0	0.2481390	0.0041819	MEIOB
1515	regulation of cellular response to stress (GO:0080135)	1/404	0.9834585	1.0000000	0	0	0.2475248	0.0041287	FLT4
1516	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	1/420	0.9859630	1.0000000	0	0	0.2380952	0.0033658	OR51E2
1517	microtubule-based process (GO:0007017)	1/437	0.9882116	1.0000000	0	0	0.2288330	0.0027136	KIF12
1518	detection of chemical stimulus involved in sensory perception (GO:0050907)	1/465	0.9911602	1.0000000	0	0	0.2150538	0.0019095	OR51E2
1519	transcription from RNA polymerase II promoter (GO:0006366)	1/470	0.9916034	1.0000000	0	0	0.2127660	0.0017940	HLF
1520	chromatin modification (GO:0016568)	1/475	0.9920246	1.0000000	0	0	0.2105263	0.0016858	HOPX
1521	regulation of cell cycle process (GO:0010564)	1/481	0.9925023	1.0000000	0	0	0.2079002	0.0015647	DMRT1
1522	positive regulation of GTPase activity (GO:0043547)	1/482	0.9925791	1.0000000	0	0	0.2074689	0.0015454	DLC1
1523	positive regulation of GTP catabolic process (GO:0033126)	1/483	0.9926551	1.0000000	0	0	0.2070393	0.0015263	DLC1
1524	detection of chemical stimulus (GO:0009593)	1/499	0.9937711	1.0000000	0	0	0.2004008	0.0012522	OR51E2

GO_Cellular_Component_2015

go_cellular %>%
  knitr::kable(
    format = "html", align = rep("c", ncol(go_cellular) + 1),
    row.names = TRUE
  ) %>%
  kableExtra::kable_styling() %>%
  kableExtra::scroll_box(height = "300px")

	Term	Overlap	P.value	Adjusted.P.value	Old.P.value	Old.Adjusted.P.value	Odds.Ratio	Combined.Score	Genes
1	integral component of plasma membrane (GO:0005887)	26/1066	0.0000240	0.0153709	0	0	2.4390244	25.9470911	CX3CR1;RAMP2;HHIP;FLT4;GRIK1;GJA1;KLRK1;TSPAN7;GPC3;CNGA1;GABRD;JAM2;CLCA4;TRGC2;TMPRSS11A;CD52;GABBR2;SLC6A13;SYT13;TMPRSS11E;TMPRSS11F;OPN1SW;CD8B;BPI;LGR5;KCNK3
2	proteinaceous extracellular matrix (GO:0005578)	8/239	0.0028629	0.9175744	0	0	3.3472803	19.6013520	ADAMTSL1;SMOC2;ECM2;SFTPD;GPC3;SPARCL1;EMID1;FBN1
3	microfibril (GO:0001527)	2/9	0.0034202	0.7307895	0	0	22.2222222	126.1788209	MFAP4;FBN1
4	voltage-gated potassium channel complex (GO:0008076)	4/70	0.0053199	0.8525140	0	0	5.7142857	29.9217183	KCNJ6;KCNA3;KCNA4;KCNJ1
5	potassium channel complex (GO:0034705)	4/71	0.0055942	0.7171766	0	0	5.6338028	29.2170409	KCNJ6;KCNA3;KCNA4;KCNJ1
6	receptor complex (GO:0043235)	8/272	0.0061980	0.6621583	0	0	2.9411765	14.9515311	GABBR2;RAMP2;CD8B;GRID1;FLT4;LEPR;GRIK1;LRP1B
7	fibril (GO:0043205)	2/13	0.0072181	0.6609718	0	0	15.3846154	75.8640519	MFAP4;FBN1
8	extracellular matrix (GO:0031012)	9/348	0.0085495	0.6850315	0	0	2.5862069	12.3152028	ADAMTSL1;SMOC2;MFAP4;ECM2;SFTPD;GPC3;SPARCL1;EMID1;FBN1
9	interstitial matrix (GO:0005614)	2/15	0.0095900	0.6830217	0	0	13.3333333	61.9604467	SMOC2;ECM2
10	photoreceptor outer segment membrane (GO:0042622)	2/16	0.0108884	0.6979480	0	0	12.5000000	56.5006873	OPN1SW;CNGA1
11	MHC class II protein complex (GO:0042613)	2/18	0.0137022	0.7984648	0	0	11.1111111	47.6688727	HLA-DOA;HLA-DQB2
12	postsynaptic membrane (GO:0045211)	6/195	0.0138327	0.7388954	0	0	3.0769231	13.1714514	CNKSR2;GABBR2;CAMK2N1;GRID1;GRIK1;GABRD
13	extrinsic component of plasma membrane (GO:0019897)	3/52	0.0152014	0.7495468	0	0	5.7692308	24.1521154	SCUBE1;MYZAP;TGM3
14	ion channel complex (GO:0034702)	7/258	0.0153427	0.7024774	0	0	2.7131783	11.3332554	KCNJ6;GRID1;KCNA3;KCNA4;GRIK1;GABRD;KCNJ1
15	neuronal cell body (GO:0043025)	7/270	0.0191830	0.8197530	0	0	2.5925926	10.2504148	CNKSR2;KISS1;SLC5A7;GPM6A;DDC;CAMK2N1;SNCG
16	multivesicular body (GO:0005771)	2/23	0.0219305	0.8785902	0	0	8.6956522	33.2163252	GJA1;HLA-DQB2
17	transmembrane transporter complex (GO:1902495)	7/286	0.0252891	0.9535466	0	0	2.4475524	9.0005880	KCNJ6;GRID1;KCNA3;KCNA4;GRIK1;GABRD;KCNJ1
18	synaptic membrane (GO:0097060)	6/228	0.0273927	0.9754837	0	0	2.6315789	9.4670514	CNKSR2;GABBR2;CAMK2N1;GRID1;GRIK1;GABRD
19	transporter complex (GO:1990351)	7/291	0.0274425	0.9258227	0	0	2.4054983	8.6493612	KCNJ6;GRID1;KCNA3;KCNA4;GRIK1;GABRD;KCNJ1
20	extrinsic component of cytoplasmic side of plasma membrane (GO:0031234)	2/26	0.0276272	0.8854512	0	0	7.6923077	27.6073469	MYZAP;TGM3
21	cell surface (GO:0009986)	9/437	0.0321362	0.9809188	0	0	2.0594966	7.0800809	ROBO2;RAMP2;KLRK1;SCUBE1;KRT4;PLA2G1B;HHIP;ANXA9;GPR124
22	extracellular space (GO:0005615)	18/1120	0.0321818	0.9376619	0	0	1.6071429	5.5227100	PLA2G1B;PROS1;A2ML1;SOGA3;SLURP1;KISS1;IGHG4;NPPC;FABP3;SCUBE1;FGF9;CCL5;FGF18;SCGB1A1;SPARCL1;SCGB3A1;KIAA0408;FBN1
23	MHC protein complex (GO:0042611)	2/29	0.0338475	0.9433138	0	0	6.8965517	23.3509763	HLA-DOA;HLA-DQB2
24	clathrin-coated endocytic vesicle membrane (GO:0030669)	2/31	0.0382674	1.0000000	0	0	6.4516129	21.0526212	CD207;HLA-DQB2
25	extracellular matrix part (GO:0044420)	4/127	0.0388027	0.9949012	0	0	3.1496063	10.2339070	MFAP4;SMOC2;FGF9;FBN1
26	cell body (GO:0044297)	7/315	0.0395159	0.9742195	0	0	2.2222222	7.1801146	CNKSR2;KISS1;SLC5A7;GPM6A;DDC;CAMK2N1;SNCG
27	basement membrane (GO:0005604)	3/77	0.0420316	0.9978620	0	0	3.8961039	12.3480501	SMOC2;FGF9;FBN1
28	synapse part (GO:0044456)	8/395	0.0456112	1.0000000	0	0	2.0253165	6.2533689	CNKSR2;GABBR2;DDC;CAMK2N1;GRID1;GRIK1;GABRD;PPFIA2
29	extracellular region (GO:0005576)	23/1585	0.0456295	1.0000000	0	0	1.4511041	4.4798508	TMPRSS11A;PCOLCE2;PLA2G1B;HHIP;PROS1;FLT4;SFTPD;PRSS27;A2ML1;TMPRSS11E;TMPRSS11F;SLURP1;KISS1;IGHG4;MFAP4;FGF9;CD8B;CCL5;FGF18;LEPR;SCG5;HCG22;FBN1
30	early endosome membrane (GO:0031901)	2/39	0.0579156	1.0000000	0	0	5.1282051	14.6090715	CD8B;CD207
31	cation channel complex (GO:0034703)	4/147	0.0603096	1.0000000	0	0	2.7210884	7.6415355	KCNJ6;KCNA3;KCNA4;KCNJ1
32	trans-Golgi network membrane (GO:0032588)	2/42	0.0660116	1.0000000	0	0	4.7619048	12.9424984	LGR5;HLA-DQB2
33	extracellular vesicular exosome (GO:0070062)	35/2717	0.0677648	1.0000000	0	0	1.2881855	3.4674249	ROBO2;GPM6A;DDC;PCOLCE2;PROS1;QPRT;KIF12;ALOX12;SEC14L3;IGHG4;ISLR;GJA1;FGF9;GPC3;SNCG;ANXA9;TGM3;CLCA4;PPFIA2;GRID1;SLC6A13;A2ML1;CYS1;CNFN;DUSP26;SLURP1;CNKSR2;MFAP4;FABP3;SCGB1A1;SPARCL1;SCGB3A1;BPI;ZNF114;FBN1
34	ciliary membrane (GO:0060170)	2/43	0.0687896	1.0000000	0	0	4.6511628	12.4497769	OPN1SW;CNGA1
35	neuronal cell body membrane (GO:0032809)	1/8	0.0772681	1.0000000	0	0	12.5000000	32.0059307	CX3CR1
36	cell body membrane (GO:0044298)	1/8	0.0772681	1.0000000	0	0	12.5000000	32.0059307	CX3CR1
37	clathrin-coated vesicle membrane (GO:0030665)	2/48	0.0832284	1.0000000	0	0	4.1666667	10.3590263	CD207;HLA-DQB2
38	ionotropic glutamate receptor complex (GO:0008328)	2/49	0.0862189	1.0000000	0	0	4.0816327	10.0035323	GRID1;GRIK1
39	secretory granule (GO:0030141)	4/176	0.1005270	1.0000000	0	0	2.2727273	5.2212019	NPPC;PLA2G1B;SCGB1A1;SCG5
40	plasma membrane region (GO:0098590)	7/395	0.1023945	1.0000000	0	0	1.7721519	4.0385962	KISS1;GJA1;OPN1SW;DLC1;SLC4A10;CNGA1;ABCG2
41	extrinsic component of membrane (GO:0019898)	3/115	0.1084360	1.0000000	0	0	2.6086957	5.7954655	SCUBE1;MYZAP;TGM3
42	Golgi-associated vesicle membrane (GO:0030660)	1/12	0.1136443	1.0000000	0	0	8.3333333	18.1223455	GJA1
43	cytoplasmic membrane-bounded vesicle (GO:0016023)	8/492	0.1214544	1.0000000	0	0	1.6260163	3.4279944	NPPC;DDC;PLA2G1B;CD207;SFTPD;SCGB1A1;SCG5;SYT13
44	axolemma (GO:0030673)	1/13	0.1225132	1.0000000	0	0	7.6923077	16.1502800	ROBO2
45	fascia adherens (GO:0005916)	1/13	0.1225132	1.0000000	0	0	7.6923077	16.1502800	GJA1
46	axonal growth cone (GO:0044295)	1/13	0.1225132	1.0000000	0	0	7.6923077	16.1502800	GPM6A
47	external side of plasma membrane (GO:0009897)	4/191	0.1251565	1.0000000	0	0	2.0942408	4.3522307	SCUBE1;CD8B;FCRL6;HLA-DQB2
48	T cell receptor complex (GO:0042101)	1/14	0.1312938	1.0000000	0	0	7.1428571	14.5022708	CD8B
49	gap junction (GO:0005921)	1/15	0.1399869	1.0000000	0	0	6.6666667	13.1080425	GJA1
50	coated vesicle membrane (GO:0030662)	2/66	0.1412394	1.0000000	0	0	3.0303030	5.9312088	CD207;HLA-DQB2
51	axon part (GO:0033267)	3/133	0.1485253	1.0000000	0	0	2.2556391	4.3015042	ROBO2;GPM6A;SNCG
52	neuronal postsynaptic density (GO:0097481)	1/18	0.1655504	1.0000000	0	0	5.5555556	9.9915545	GRIK1
53	I band (GO:0031674)	1/19	0.1739024	1.0000000	0	0	5.2631579	9.2066381	MYZAP
54	anchored component of membrane (GO:0031225)	3/150	0.1900320	1.0000000	0	0	2.0000000	3.3211257	CD52;LYPD1;GPC3
55	cornified envelope (GO:0001533)	1/23	0.2064868	1.0000000	0	0	4.3478261	6.8587782	CNFN
56	side of membrane (GO:0098552)	4/235	0.2094034	1.0000000	0	0	1.7021277	2.6612640	SCUBE1;CD8B;FCRL6;HLA-DQB2
57	Golgi lumen (GO:0005796)	2/86	0.2125388	1.0000000	0	0	2.3255814	3.6014667	PROS1;GPC3
58	cortical actin cytoskeleton (GO:0030864)	1/24	0.2144310	1.0000000	0	0	4.1666667	6.4156966	MYZAP
59	connexon complex (GO:0005922)	1/24	0.2144310	1.0000000	0	0	4.1666667	6.4156966	GJA1
60	presynaptic active zone (GO:0048786)	1/25	0.2222961	1.0000000	0	0	4.0000000	6.0149794	PPFIA2
61	collagen trimer (GO:0005581)	2/91	0.2309240	1.0000000	0	0	2.1978022	3.2212458	SFTPD;EMID1
62	endocytic vesicle membrane (GO:0030666)	2/94	0.2420055	1.0000000	0	0	2.1276596	3.0187127	CD207;HLA-DQB2
63	integral component of lumenal side of endoplasmic reticulum membrane (GO:0071556)	1/28	0.2454244	1.0000000	0	0	3.5714286	5.0170219	HLA-DQB2
64	endocytic vesicle (GO:0030139)	2/96	0.2494068	1.0000000	0	0	2.0833333	2.8930625	SFTPD;CD207
65	postsynaptic density (GO:0014069)	2/98	0.2568151	1.0000000	0	0	2.0408163	2.7742832	CAMK2N1;GRIK1
66	ER to Golgi transport vesicle membrane (GO:0012507)	1/30	0.2604618	1.0000000	0	0	3.3333333	4.4843302	HLA-DQB2
67	lysosome (GO:0005764)	4/261	0.2651645	1.0000000	0	0	1.5325670	2.0343371	GJA1;RAMP2;SFTPD;SLC7A14
68	lytic vacuole (GO:0000323)	4/261	0.2651645	1.0000000	0	0	1.5325670	2.0343371	GJA1;RAMP2;SFTPD;SLC7A14
69	axon terminus (GO:0043679)	1/34	0.2896478	1.0000000	0	0	2.9411765	3.6443812	SNCG
70	late endosome (GO:0005770)	2/107	0.2901569	1.0000000	0	0	1.8691589	2.3127732	GJA1;HLA-DQB2
71	neuron projection membrane (GO:0032589)	1/35	0.2967634	1.0000000	0	0	2.8571429	3.4709146	ROBO2
72	rough endoplasmic reticulum (GO:0005791)	1/35	0.2967634	1.0000000	0	0	2.8571429	3.4709146	SCGB1A1
73	contractile fiber (GO:0043292)	1/36	0.3038081	1.0000000	0	0	2.7777778	3.3093308	GJA1
74	intercalated disc (GO:0014704)	1/37	0.3107825	1.0000000	0	0	2.7027027	3.1585455	GJA1
75	cell projection membrane (GO:0031253)	3/196	0.3123712	1.0000000	0	0	1.5306122	1.7809638	ROBO2;OPN1SW;CNGA1
76	membrane raft (GO:0045121)	3/200	0.3233045	1.0000000	0	0	1.5000000	1.6937411	GJA1;DLC1;KCNA3
77	apical plasma membrane (GO:0016324)	3/201	0.3260385	1.0000000	0	0	1.4925373	1.6727460	KISS1;GJA1;ABCG2
78	anchored component of plasma membrane (GO:0046658)	1/40	0.3312915	1.0000000	0	0	2.5000000	2.7618913	GPC3
79	vacuole (GO:0005773)	4/293	0.3368702	1.0000000	0	0	1.3651877	1.4854027	GJA1;RAMP2;SFTPD;SLC7A14
80	transport vesicle membrane (GO:0030658)	1/41	0.3379920	1.0000000	0	0	2.4390244	2.6456903	HLA-DQB2
81	presynaptic membrane (GO:0042734)	1/44	0.3576952	1.0000000	0	0	2.2727273	2.3365317	GRIK1
82	cell-cell contact zone (GO:0044291)	1/44	0.3576952	1.0000000	0	0	2.2727273	2.3365317	GJA1
83	neuron projection terminus (GO:0044306)	1/44	0.3576952	1.0000000	0	0	2.2727273	2.3365317	SNCG
84	lateral plasma membrane (GO:0016328)	1/46	0.3705054	1.0000000	0	0	2.1739130	2.1584503	GJA1
85	cell-cell adherens junction (GO:0005913)	1/47	0.3768149	1.0000000	0	0	2.1276596	2.0765984	GJA1
86	filopodium (GO:0030175)	1/48	0.3830614	1.0000000	0	0	2.0833333	1.9990833	GPM6A
87	platelet alpha granule lumen (GO:0031093)	1/48	0.3830614	1.0000000	0	0	2.0833333	1.9990833	PROS1
88	cortical cytoskeleton (GO:0030863)	1/50	0.3953682	1.0000000	0	0	2.0000000	1.8558758	MYZAP
89	cytoplasmic mRNA processing body (GO:0000932)	1/50	0.3953682	1.0000000	0	0	2.0000000	1.8558758	APOBEC3H
90	chloride channel complex (GO:0034707)	1/50	0.3953682	1.0000000	0	0	2.0000000	1.8558758	GABRD
91	cytoplasmic vesicle membrane (GO:0030659)	3/229	0.4021216	1.0000000	0	0	1.3100437	1.1934508	GJA1;CD207;HLA-DQB2
92	microtubule associated complex (GO:0005875)	2/138	0.4023514	1.0000000	0	0	1.4492754	1.3194631	DCX;KIF12
93	early endosome (GO:0005769)	2/141	0.4128121	1.0000000	0	0	1.4184397	1.2549827	GJA1;HLA-DQB2
94	kinesin complex (GO:0005871)	1/53	0.4133717	1.0000000	0	0	1.8867925	1.6668075	KIF12
95	coated pit (GO:0005905)	1/54	0.4192536	1.0000000	0	0	1.8518519	1.6097765	RAMP2
96	dendrite (GO:0030425)	3/236	0.4208286	1.0000000	0	0	1.2711864	1.1002496	CAMK2N1;GRID1;GRIK1
97	intermediate filament cytoskeleton (GO:0045111)	1/55	0.4250768	1.0000000	0	0	1.8181818	1.5554281	KRT4
98	cell-cell junction (GO:0005911)	4/335	0.4316984	1.0000000	0	0	1.1940299	1.0030187	GJA1;KIAA1462;SKAP1;JAM2
99	plasma membrane raft (GO:0044853)	1/58	0.4422000	1.0000000	0	0	1.7241379	1.4068845	DLC1
100	caveola (GO:0005901)	1/58	0.4422000	1.0000000	0	0	1.7241379	1.4068845	DLC1
101	vesicle membrane (GO:0012506)	3/249	0.4550271	1.0000000	0	0	1.2048193	0.9486727	GJA1;CD207;HLA-DQB2
102	secretory granule lumen (GO:0034774)	1/62	0.4642441	1.0000000	0	0	1.6129032	1.2376529	PROS1
103	transport vesicle (GO:0030133)	1/62	0.4642441	1.0000000	0	0	1.6129032	1.2376529	SYT13
104	endoplasmic reticulum membrane (GO:0005789)	5/449	0.4675027	1.0000000	0	0	1.1135857	0.8467150	GJA1;CYP2W1;CYP2A13;PROS1;CYP2F1
105	sarcolemma (GO:0042383)	1/63	0.4696183	1.0000000	0	0	1.5873016	1.1997381	ALOX12
106	nuclear matrix (GO:0016363)	1/64	0.4749389	1.0000000	0	0	1.5625000	1.1633893	RUNX1T1
107	blood microparticle (GO:0072562)	2/161	0.4800636	1.0000000	0	0	1.2422360	0.9115984	IGHG4;PROS1
108	lysosomal lumen (GO:0043202)	1/67	0.4905840	1.0000000	0	0	1.4925373	1.0629235	GPC3
109	cytoplasmic vesicle part (GO:0044433)	4/363	0.4930163	1.0000000	0	0	1.1019284	0.7792982	GJA1;PROS1;CD207;HLA-DQB2
110	vacuolar lumen (GO:0005775)	1/70	0.5057652	1.0000000	0	0	1.4285714	0.9738324	GPC3
111	endosome membrane (GO:0010008)	2/175	0.5242613	1.0000000	0	0	1.1428571	0.7380171	CD8B;CD207
112	vesicle lumen (GO:0031983)	1/76	0.5347903	1.0000000	0	0	1.3157895	0.8235271	PROS1
113	cytoplasmic membrane-bounded vesicle lumen (GO:0060205)	1/76	0.5347903	1.0000000	0	0	1.3157895	0.8235271	PROS1
114	vacuolar part (GO:0044437)	3/285	0.5448057	1.0000000	0	0	1.0526316	0.6392906	GPC3;HLA-DOA;HLA-DQB2
115	synaptic vesicle (GO:0008021)	1/86	0.5794443	1.0000000	0	0	1.1627907	0.6345183	DDC
116	intermediate filament (GO:0005882)	2/196	0.5856881	1.0000000	0	0	1.0204082	0.5458856	GJA1;KRT4
117	lysosomal membrane (GO:0005765)	2/196	0.5856881	1.0000000	0	0	1.0204082	0.5458856	HLA-DOA;HLA-DQB2
118	endosomal part (GO:0044440)	2/200	0.5967066	1.0000000	0	0	1.0000000	0.5163298	CD8B;CD207
119	Golgi membrane (GO:0000139)	3/308	0.5974940	1.0000000	0	0	0.9740260	0.5016341	GJA1;PROS1;HLA-DQB2
120	integral component of endoplasmic reticulum membrane (GO:0030176)	1/94	0.6120753	1.0000000	0	0	1.0638298	0.5222340	HLA-DQB2
121	leading edge membrane (GO:0031256)	1/95	0.6159728	1.0000000	0	0	1.0526316	0.5100552	ROBO2
122	vacuolar membrane (GO:0005774)	2/208	0.6180843	1.0000000	0	0	0.9615385	0.4626254	HLA-DOA;HLA-DQB2
123	keratin filament (GO:0045095)	1/98	0.6274332	1.0000000	0	0	1.0204082	0.4756306	KRT4
124	growth cone (GO:0030426)	1/99	0.6311772	1.0000000	0	0	1.0101010	0.4648167	GPM6A
125	site of polarized growth (GO:0030427)	1/102	0.6421861	1.0000000	0	0	0.9803922	0.4341933	GPM6A
126	cell cortex part (GO:0044448)	1/105	0.6528680	1.0000000	0	0	0.9523810	0.4060766	MYZAP
127	ciliary part (GO:0044441)	2/223	0.6558105	1.0000000	0	0	0.8968610	0.3783707	OPN1SW;CNGA1
128	occluding junction (GO:0070160)	1/108	0.6632325	1.0000000	0	0	0.9259259	0.3802127	JAM2
129	tight junction (GO:0005923)	1/108	0.6632325	1.0000000	0	0	0.9259259	0.3802127	JAM2
130	peroxisome (GO:0005777)	1/109	0.6666184	1.0000000	0	0	0.9174312	0.3720527	ACOXL
131	nuclear envelope (GO:0005635)	1/110	0.6699705	1.0000000	0	0	0.9090909	0.3641106	SCGB1A1
132	ribonucleoprotein granule (GO:0035770)	1/111	0.6732890	1.0000000	0	0	0.9009009	0.3563789	APOBEC3H
133	cytoplasmic ribonucleoprotein granule (GO:0036464)	1/111	0.6732890	1.0000000	0	0	0.9009009	0.3563789	APOBEC3H
134	mitochondrial outer membrane (GO:0005741)	1/118	0.6956073	1.0000000	0	0	0.8474576	0.3076017	GJA1
135	organelle envelope (GO:0031967)	1/123	0.7106138	1.0000000	0	0	0.8130081	0.2777449	SCGB1A1
136	microbody (GO:0042579)	1/123	0.7106138	1.0000000	0	0	0.8130081	0.2777449	ACOXL
137	envelope (GO:0031975)	1/123	0.7106138	1.0000000	0	0	0.8130081	0.2777449	SCGB1A1
138	organelle outer membrane (GO:0031968)	1/131	0.7331076	1.0000000	0	0	0.7633588	0.2369945	GJA1
139	outer membrane (GO:0019867)	1/137	0.7488283	1.0000000	0	0	0.7299270	0.2111281	GJA1
140	basolateral plasma membrane (GO:0016323)	1/138	0.7513574	1.0000000	0	0	0.7246377	0.2071550	SLC4A10
141	Golgi apparatus (GO:0005794)	7/865	0.7667659	1.0000000	0	0	0.8092486	0.2149152	CNKSR2;GJA1;KCNJ6;ST6GAL2;DUSP26;EMID1;JAKMIP2
142	axon (GO:0030424)	1/161	0.8030171	1.0000000	0	0	0.6211180	0.1362604	DDC
143	chromosome (GO:0005694)	1/166	0.8127489	1.0000000	0	0	0.6024096	0.1248994	MEIOB
144	contractile fiber part (GO:0044449)	1/167	0.8146371	1.0000000	0	0	0.5988024	0.1227620	MYZAP
145	actin cytoskeleton (GO:0015629)	1/193	0.8576013	1.0000000	0	0	0.5181347	0.0795938	MYOZ1
146	focal adhesion (GO:0005925)	2/352	0.8698337	1.0000000	0	0	0.5681818	0.0792348	GJA1;DLC1
147	cell-substrate adherens junction (GO:0005924)	2/358	0.8759198	1.0000000	0	0	0.5586592	0.0740116	GJA1;DLC1
148	microtubule (GO:0005874)	2/360	0.8778898	1.0000000	0	0	0.5555556	0.0723523	DCX;KIF12
149	cell-substrate junction (GO:0030055)	2/362	0.8798311	1.0000000	0	0	0.5524862	0.0707322	GJA1;DLC1
150	integral component of organelle membrane (GO:0031301)	1/211	0.8813857	1.0000000	0	0	0.4739336	0.0598388	HLA-DQB2
151	synapse (GO:0045202)	1/243	0.9143243	1.0000000	0	0	0.4115226	0.0368601	FRRS1L
152	cilium (GO:0005929)	1/243	0.9143243	1.0000000	0	0	0.4115226	0.0368601	CYS1
153	adherens junction (GO:0005912)	2/405	0.9152623	1.0000000	0	0	0.4938272	0.0437257	GJA1;DLC1
154	perinuclear region of cytoplasm (GO:0048471)	2/411	0.9193490	1.0000000	0	0	0.4866180	0.0409195	CX3CR1;SNCG
155	anchoring junction (GO:0070161)	2/419	0.9245113	1.0000000	0	0	0.4773270	0.0374654	GJA1;DLC1
156	transcription factor complex (GO:0005667)	1/268	0.9335761	1.0000000	0	0	0.3731343	0.0256466	BEX1
157	intracellular (GO:0005622)	4/730	0.9369519	1.0000000	0	0	0.5479452	0.0356840	SEC14L3;ZNF728;DCX;ZNF114
158	mitochondrial membrane (GO:0031966)	1/457	0.9904020	1.0000000	0	0	0.2188184	0.0021104	GJA1
159	cytosol (GO:0005829)	15/2529	0.9928792	1.0000000	0	0	0.5931198	0.0042386	DDC;ADH1C;STAC;ADH1B;QPRT;ALOX12;IFIT1;OASL;CH25H;GJA1;FABP3;DLC1;DCX;UBASH3A;ANXA9
160	mitochondrion (GO:0005739)	2/1269	0.9999686	1.0000000	0	0	0.1576044	0.0000049	DUSP26;ABCG2
161	nucleolus (GO:0005730)	2/1653	0.9999955	1.0000000	0	0	0.1209921	0.0000005	FGF18;OASL

GO_Molecular_Function_2015

go_molecular %>%
  knitr::kable(
    format = "html", align = rep("c", ncol(go_molecular) + 1),
    row.names = TRUE
  ) %>%
  kableExtra::kable_styling() %>%
  kableExtra::scroll_box(height = "300px")

	Term	Overlap	P.value	Adjusted.P.value	Old.P.value	Old.Adjusted.P.value	Odds.Ratio	Combined.Score	Genes
1	voltage-gated potassium channel activity (GO:0005249)	6/86	0.0002244	0.2549732	0	0	6.9767442	58.6176657	KCNJ6;CNGA1;KCNA3;KCNA4;KCNJ1;KCNK3
2	potassium channel activity (GO:0005267)	6/118	0.0012087	0.6865446	0	0	5.0847458	34.1603669	KCNJ6;CNGA1;KCNA3;KCNA4;KCNJ1;KCNK3
3	channel activity (GO:0015267)	12/427	0.0012766	0.4834037	0	0	2.8103044	18.7266307	GPM6A;GJA1;KCNJ6;GRID1;KCNA3;CNGA1;KCNA4;GRIK1;GABRD;KCNJ1;CLCA4;KCNK3
4	passive transmembrane transporter activity (GO:0022803)	12/427	0.0012766	0.3625528	0	0	2.8103044	18.7266307	GPM6A;GJA1;KCNJ6;GRID1;KCNA3;CNGA1;KCNA4;GRIK1;GABRD;KCNJ1;CLCA4;KCNK3
5	iron ion binding (GO:0005506)	7/172	0.0017549	0.3987215	0	0	4.0697674	25.8239879	CH25H;CYP2W1;CYP2A13;P4HA3;ALOX12;CYP4F22;CYP2F1
6	ion channel activity (GO:0005216)	11/396	0.0022098	0.4183888	0	0	2.7777778	16.9857035	GPM6A;KCNJ6;GRID1;KCNA3;CNGA1;KCNA4;GRIK1;GABRD;KCNJ1;CLCA4;KCNK3
7	potassium ion transmembrane transporter activity (GO:0015079)	6/138	0.0026751	0.4341297	0	0	4.3478261	25.7555234	KCNJ6;CNGA1;KCNA3;KCNA4;KCNJ1;KCNK3
8	substrate-specific channel activity (GO:0022838)	11/406	0.0026774	0.3801896	0	0	2.7093596	16.0472995	GPM6A;KCNJ6;GRID1;KCNA3;CNGA1;KCNA4;GRIK1;GABRD;KCNJ1;CLCA4;KCNK3
9	alcohol dehydrogenase (NAD) activity (GO:0004022)	2/8	0.0026778	0.3379938	0	0	25.0000000	148.0692967	ADH1C;ADH1B
10	cytidine deaminase activity (GO:0004126)	2/8	0.0026778	0.3041944	0	0	25.0000000	148.0692967	APOBEC2;APOBEC3H
11	monooxygenase activity (GO:0004497)	5/99	0.0031830	0.3287152	0	0	5.0505051	29.0400857	CH25H;CYP2W1;CYP2A13;CYP4F22;CYP2F1
12	ligand-gated ion channel activity (GO:0015276)	6/145	0.0034178	0.3235552	0	0	4.1379310	23.4982656	KCNJ6;GRID1;CNGA1;GRIK1;KCNJ1;GABRD
13	ligand-gated channel activity (GO:0022834)	6/145	0.0034178	0.2986663	0	0	4.1379310	23.4982656	KCNJ6;GRID1;CNGA1;GRIK1;KCNJ1;GABRD
14	voltage-gated cation channel activity (GO:0022843)	6/149	0.0039058	0.3169247	0	0	4.0268456	22.3300765	KCNJ6;CNGA1;KCNA3;KCNA4;KCNJ1;KCNK3
15	MHC class II receptor activity (GO:0032395)	2/11	0.0051570	0.3905584	0	0	18.1818182	95.7708415	HLA-DOA;HLA-DQB2
16	gated channel activity (GO:0022836)	9/323	0.0053542	0.3801493	0	0	2.7863777	14.5723959	KCNJ6;GRID1;KCNA3;CNGA1;KCNA4;GRIK1;GABRD;KCNJ1;KCNK3
17	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen (GO:0016705)	6/163	0.0060252	0.4026243	0	0	3.6809816	18.8164667	CH25H;CYP2W1;CYP2A13;P4HA3;CYP4F22;CYP2F1
18	voltage-gated channel activity (GO:0022832)	6/189	0.0120086	0.7578743	0	0	3.1746032	14.0385224	KCNJ6;CNGA1;KCNA3;KCNA4;KCNJ1;KCNK3
19	voltage-gated ion channel activity (GO:0005244)	6/189	0.0120086	0.7179862	0	0	3.1746032	14.0385224	KCNJ6;CNGA1;KCNA3;KCNA4;KCNJ1;KCNK3
20	extracellular-glutamate-gated ion channel activity (GO:0005234)	2/18	0.0137022	0.7782852	0	0	11.1111111	47.6688727	GRID1;GRIK1
21	ionotropic glutamate receptor activity (GO:0004970)	2/19	0.0152144	0.8230292	0	0	10.5263158	44.0579974	GRID1;GRIK1
22	aromatase activity (GO:0070330)	2/21	0.0184420	0.9522790	0	0	9.5238095	38.0297462	CYP2A13;CYP2F1
23	metal ion transmembrane transporter activity (GO:0046873)	9/400	0.0196012	0.9681294	0	0	2.2500000	8.8473688	SLC5A7;GPM6A;KCNJ6;SLC6A13;KCNA3;CNGA1;KCNA4;KCNJ1;KCNK3
24	GABA receptor activity (GO:0016917)	2/22	0.0201544	0.9539738	0	0	9.0909091	35.4939443	GABBR2;GABRD
25	inward rectifier potassium channel activity (GO:0005242)	2/22	0.0201544	0.9158148	0	0	9.0909091	35.4939443	KCNJ6;KCNJ1
26	monovalent inorganic cation transmembrane transporter activity (GO:0015077)	8/343	0.0224125	0.9792545	0	0	2.3323615	8.8586258	SLC5A7;KCNJ6;SLC6A13;KCNA3;CNGA1;KCNA4;KCNJ1;KCNK3
27	fibroblast growth factor receptor binding (GO:0005104)	2/24	0.0237689	1.0000000	0	0	8.3333333	31.1614659	FGF9;FGF18
28	cation channel activity (GO:0005261)	7/285	0.0248727	1.0000000	0	0	2.4561404	9.0729396	GPM6A;KCNJ6;KCNA3;CNGA1;KCNA4;KCNJ1;KCNK3
29	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen (GO:0016712)	2/25	0.0256683	1.0000000	0	0	8.0000000	29.2999902	CYP2A13;CYP2F1
30	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen (GO:0016702)	2/25	0.0256683	0.9719727	0	0	8.0000000	29.2999902	P4HA3;ALOX12
31	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen (GO:0016701)	2/26	0.0276272	1.0000000	0	0	7.6923077	27.6073469	P4HA3;ALOX12
32	amino acid transmembrane transporter activity (GO:0015171)	3/66	0.0284510	1.0000000	0	0	4.5454545	16.1798713	SLC7A14;SLC6A13;SLC38A4
33	glutamate receptor activity (GO:0008066)	2/27	0.0296442	1.0000000	0	0	7.4074074	26.0628716	GRID1;GRIK1
34	coreceptor activity (GO:0015026)	2/27	0.0296442	0.9904662	0	0	7.4074074	26.0628716	RAMP2;CD8B
35	deaminase activity (GO:0019239)	2/29	0.0338475	1.0000000	0	0	6.8965517	23.3509763	APOBEC2;APOBEC3H
36	anion transmembrane transporter activity (GO:0008509)	6/245	0.0369668	1.0000000	0	0	2.4489796	8.0760842	SLC6A13;SLC7A14;SLC4A10;GABRD;CLCA4;SLC38A4
37	extracellular ligand-gated ion channel activity (GO:0005230)	3/74	0.0380556	1.0000000	0	0	4.0540541	13.2515162	GRID1;GRIK1;GABRD
38	SH2 domain binding (GO:0042169)	2/31	0.0382674	1.0000000	0	0	6.4516129	21.0526212	DLC1;SKAP1
39	symporter activity (GO:0015293)	4/130	0.0416931	1.0000000	0	0	3.0769231	9.7766739	SLC5A7;SLC6A13;SLC4A10;SLC38A4
40	beta-tubulin binding (GO:0048487)	2/35	0.0477172	1.0000000	0	0	5.7142857	17.3855107	GJA1;SNCG
41	heme binding (GO:0020037)	4/137	0.0488995	1.0000000	0	0	2.9197080	8.8116443	CYP2W1;CYP2A13;CYP4F22;CYP2F1
42	RNA polymerase II activating transcription factor binding (GO:0001102)	2/36	0.0501995	1.0000000	0	0	5.5555556	16.6208344	BEX1;DUSP26
43	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines (GO:0016814)	2/36	0.0501995	1.0000000	0	0	5.5555556	16.6208344	APOBEC2;APOBEC3H
44	delayed rectifier potassium channel activity (GO:0005251)	2/36	0.0501995	1.0000000	0	0	5.5555556	16.6208344	KCNA3;KCNA4
45	carboxylic acid binding (GO:0031406)	5/200	0.0508440	1.0000000	0	0	2.5000000	7.4474830	FABP3;DDC;PLA2G1B;P4HA3;ANXA9
46	organic acid binding (GO:0043177)	5/201	0.0517369	1.0000000	0	0	2.4875622	7.3671242	FABP3;DDC;PLA2G1B;P4HA3;ANXA9
47	heparin binding (GO:0008201)	4/140	0.0521854	1.0000000	0	0	2.8571429	8.4370074	SMOC2;ECM2;FGF9;PCOLCE2
48	sulfur compound binding (GO:1901681)	5/206	0.0563388	1.0000000	0	0	2.4271845	6.9814843	SMOC2;ECM2;FGF9;PCOLCE2;GPC3
49	tetrapyrrole binding (GO:0046906)	4/146	0.0591100	1.0000000	0	0	2.7397260	7.7489166	CYP2W1;CYP2A13;CYP4F22;CYP2F1
50	inorganic cation transmembrane transporter activity (GO:0022890)	9/497	0.0627487	1.0000000	0	0	1.8108652	5.0135933	SLC5A7;GPM6A;KCNJ6;SLC6A13;KCNA3;CNGA1;KCNA4;KCNJ1;KCNK3
51	protein phosphatase binding (GO:0019903)	3/94	0.0682467	1.0000000	0	0	3.1914894	8.5679557	FCRL6;FLT4;SKAP1
52	axon guidance receptor activity (GO:0008046)	1/8	0.0772681	1.0000000	0	0	12.5000000	32.0059307	ROBO2
53	intracellular cAMP activated cation channel activity (GO:0005222)	1/8	0.0772681	1.0000000	0	0	12.5000000	32.0059307	CNGA1
54	heme transporter activity (GO:0015232)	1/8	0.0772681	1.0000000	0	0	12.5000000	32.0059307	ABCG2
55	carboxylic acid transmembrane transporter activity (GO:0046943)	3/101	0.0807525	1.0000000	0	0	2.9702970	7.4743550	SLC6A13;SLC7A14;SLC38A4
56	excitatory extracellular ligand-gated ion channel activity (GO:0005231)	2/48	0.0832284	1.0000000	0	0	4.1666667	10.3590263	GRID1;GRIK1
57	organic acid transmembrane transporter activity (GO:0005342)	3/104	0.0863951	1.0000000	0	0	2.8846154	7.0639147	SLC6A13;SLC7A14;SLC38A4
58	potassium ion binding (GO:0030955)	1/9	0.0864991	1.0000000	0	0	11.1111111	27.1957962	KCNA4
59	phospholipase activator activity (GO:0016004)	1/9	0.0864991	1.0000000	0	0	11.1111111	27.1957962	CCL5
60	calcium-dependent phospholipase A2 activity (GO:0047498)	1/9	0.0864991	1.0000000	0	0	11.1111111	27.1957962	PLA2G1B
61	fatty acid transporter activity (GO:0015245)	1/9	0.0864991	1.0000000	0	0	11.1111111	27.1957962	FABP3
62	peptidyl-proline 4-dioxygenase activity (GO:0031545)	1/9	0.0864991	1.0000000	0	0	11.1111111	27.1957962	P4HA3
63	protein-glutamine gamma-glutamyltransferase activity (GO:0003810)	1/9	0.0864991	1.0000000	0	0	11.1111111	27.1957962	TGM3
64	opioid receptor activity (GO:0004985)	1/9	0.0864991	1.0000000	0	0	11.1111111	27.1957962	NPBWR1
65	serine-type endopeptidase activity (GO:0004252)	4/167	0.0869547	1.0000000	0	0	2.3952096	5.8499844	TMPRSS11A;PRSS27;TMPRSS11E;TMPRSS11F
66	solute:sodium symporter activity (GO:0015370)	2/50	0.0892415	1.0000000	0	0	4.0000000	9.6656385	SLC5A7;SLC6A13
67	calcium ion binding (GO:0005509)	11/698	0.0922616	1.0000000	0	0	1.5759312	3.7556440	SMOC2;SCUBE1;PLA2G1B;PROS1;PADI3;SPARCL1;ANXA9;TGM3;LRP1B;CDH7;FBN1
68	tubulin binding (GO:0015631)	5/241	0.0948925	1.0000000	0	0	2.0746888	4.8859139	GJA1;DCX;SNCG;KIF12;JAKMIP2
69	sodium:amino acid symporter activity (GO:0005283)	1/10	0.0956382	1.0000000	0	0	10.0000000	23.4718325	SLC6A13
70	oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor (GO:0016634)	1/10	0.0956382	1.0000000	0	0	10.0000000	23.4718325	ACOXL
71	low-density lipoprotein receptor activity (GO:0005041)	1/10	0.0956382	1.0000000	0	0	10.0000000	23.4718325	LRP1B
72	hydrolase activity, acting on ether bonds (GO:0016801)	1/10	0.0956382	1.0000000	0	0	10.0000000	23.4718325	ALOX12
73	activating transcription factor binding (GO:0033613)	2/53	0.0984918	1.0000000	0	0	3.7735849	8.7463472	BEX1;DUSP26
74	cyclic nucleotide-gated ion channel activity (GO:0043855)	1/11	0.1046863	1.0000000	0	0	9.0909091	20.5162457	CNGA1
75	receptor antagonist activity (GO:0048019)	1/11	0.1046863	1.0000000	0	0	9.0909091	20.5162457	CCL5
76	outward rectifier potassium channel activity (GO:0015271)	1/11	0.1046863	1.0000000	0	0	9.0909091	20.5162457	KCNA3
77	alcohol transmembrane transporter activity (GO:0015665)	1/11	0.1046863	1.0000000	0	0	9.0909091	20.5162457	SLC5A7
78	toxic substance binding (GO:0015643)	1/11	0.1046863	1.0000000	0	0	9.0909091	20.5162457	HLA-DQB2
79	lipase activator activity (GO:0060229)	1/11	0.1046863	1.0000000	0	0	9.0909091	20.5162457	CCL5
80	intracellular cyclic nucleotide activated cation channel activity (GO:0005221)	1/11	0.1046863	1.0000000	0	0	9.0909091	20.5162457	CNGA1
81	S100 protein binding (GO:0044548)	1/11	0.1046863	1.0000000	0	0	9.0909091	20.5162457	KCNK3
82	long-chain fatty acid binding (GO:0036041)	1/11	0.1046863	1.0000000	0	0	9.0909091	20.5162457	FABP3
83	p53 binding (GO:0002039)	2/56	0.1079976	1.0000000	0	0	3.5714286	7.9487379	ZNF385B;DUSP26
84	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines (GO:0016813)	1/12	0.1136443	1.0000000	0	0	8.3333333	18.1223455	PADI3
85	cation:amino acid symporter activity (GO:0005416)	1/12	0.1136443	1.0000000	0	0	8.3333333	18.1223455	SLC6A13
86	receptor inhibitor activity (GO:0030547)	1/12	0.1136443	1.0000000	0	0	8.3333333	18.1223455	CCL5
87	gap junction channel activity (GO:0005243)	1/12	0.1136443	1.0000000	0	0	8.3333333	18.1223455	GJA1
88	monocarboxylic acid binding (GO:0033293)	2/59	0.1177356	1.0000000	0	0	3.3898305	7.2519111	FABP3;PLA2G1B
89	serine-type peptidase activity (GO:0008236)	4/188	0.1200394	1.0000000	0	0	2.1276596	4.5105013	TMPRSS11A;PRSS27;TMPRSS11E;TMPRSS11F
90	G-protein coupled peptide receptor activity (GO:0008528)	3/121	0.1212860	1.0000000	0	0	2.4793388	5.2304234	MC4R;CX3CR1;NPBWR1
91	enzyme inhibitor activity (GO:0004857)	6/336	0.1216895	1.0000000	0	0	1.7857143	3.7612194	CAMK2N1;PROS1;SCGB1A1;GPC3;SCG5;A2ML1
92	MHC class I protein binding (GO:0042288)	1/13	0.1225132	1.0000000	0	0	7.6923077	16.1502800	CD8B
93	alkali metal ion binding (GO:0031420)	1/13	0.1225132	1.0000000	0	0	7.6923077	16.1502800	KCNA4
94	exodeoxyribonuclease activity, producing 5’-phosphomonoesters (GO:0016895)	1/13	0.1225132	1.0000000	0	0	7.6923077	16.1502800	MEIOB
95	phospholipase inhibitor activity (GO:0004859)	1/13	0.1225132	1.0000000	0	0	7.6923077	16.1502800	SCGB1A1
96	exodeoxyribonuclease activity (GO:0004529)	1/13	0.1225132	1.0000000	0	0	7.6923077	16.1502800	MEIOB
97	peptidyl-proline dioxygenase activity (GO:0031543)	1/13	0.1225132	1.0000000	0	0	7.6923077	16.1502800	P4HA3
98	inorganic anion exchanger activity (GO:0005452)	1/13	0.1225132	1.0000000	0	0	7.6923077	16.1502800	SLC4A10
99	glycosaminoglycan binding (GO:0005539)	4/190	0.1234406	1.0000000	0	0	2.1052632	4.4042012	SMOC2;ECM2;FGF9;PCOLCE2
100	secondary active transmembrane transporter activity (GO:0015291)	4/191	0.1251565	1.0000000	0	0	2.0942408	4.3522307	SLC5A7;SLC6A13;SLC4A10;SLC38A4
101	serine hydrolase activity (GO:0017171)	4/191	0.1251565	1.0000000	0	0	2.0942408	4.3522307	TMPRSS11A;PRSS27;TMPRSS11E;TMPRSS11F
102	peptide receptor activity (GO:0001653)	3/123	0.1256888	1.0000000	0	0	2.4390244	5.0584047	MC4R;CX3CR1;NPBWR1
103	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds (GO:0016810)	3/123	0.1256888	1.0000000	0	0	2.4390244	5.0584047	APOBEC2;APOBEC3H;PADI3
104	collagen binding (GO:0005518)	2/62	0.1276839	1.0000000	0	0	3.2258065	6.6393466	ECM2;PCOLCE2
105	lipoprotein particle receptor activity (GO:0030228)	1/14	0.1312938	1.0000000	0	0	7.1428571	14.5022708	LRP1B
106	protein tyrosine kinase activator activity (GO:0030296)	1/14	0.1312938	1.0000000	0	0	7.1428571	14.5022708	CCL5
107	acyl-CoA dehydrogenase activity (GO:0003995)	1/15	0.1399869	1.0000000	0	0	6.6666667	13.1080425	ACOXL
108	monosaccharide binding (GO:0048029)	2/66	0.1412394	1.0000000	0	0	3.0303030	5.9312088	P4HA3;CD207
109	organic anion transmembrane transporter activity (GO:0008514)	3/130	0.1415370	1.0000000	0	0	2.3076923	4.5119861	SLC6A13;SLC7A14;SLC38A4
110	oxidoreductase activity, acting on CH-OH group of donors (GO:0016614)	3/131	0.1438539	1.0000000	0	0	2.2900763	4.4403596	ADH1C;ADH1B;HHIP
111	carbohydrate binding (GO:0030246)	5/278	0.1469365	1.0000000	0	0	1.7985612	3.4491988	KLRK1;P4HA3;CD207;SFTPD;CLEC4F
112	Rac GTPase activator activity (GO:0030675)	1/16	0.1485935	1.0000000	0	0	6.2500000	11.9158813	DLC1
113	MHC protein complex binding (GO:0023023)	1/16	0.1485935	1.0000000	0	0	6.2500000	11.9158813	HLA-DOA
114	steroid hydroxylase activity (GO:0008395)	1/16	0.1485935	1.0000000	0	0	6.2500000	11.9158813	CH25H
115	MHC class II protein complex binding (GO:0023026)	1/16	0.1485935	1.0000000	0	0	6.2500000	11.9158813	HLA-DOA
116	quinone binding (GO:0048038)	1/16	0.1485935	1.0000000	0	0	6.2500000	11.9158813	HHIP
117	drug transmembrane transporter activity (GO:0015238)	1/16	0.1485935	1.0000000	0	0	6.2500000	11.9158813	ABCG2
118	photoreceptor activity (GO:0009881)	1/16	0.1485935	1.0000000	0	0	6.2500000	11.9158813	OPN1SW
119	phosphatase binding (GO:0019902)	3/136	0.1556231	1.0000000	0	0	2.2058824	4.1036430	FCRL6;FLT4;SKAP1
120	cGMP binding (GO:0030553)	1/17	0.1571144	1.0000000	0	0	5.8823529	10.8869493	CNGA1
121	heparan sulfate proteoglycan binding (GO:0043395)	1/17	0.1571144	1.0000000	0	0	5.8823529	10.8869493	GPC3
122	peptide hormone receptor binding (GO:0051428)	1/17	0.1571144	1.0000000	0	0	5.8823529	10.8869493	NPPC
123	CCR chemokine receptor binding (GO:0048020)	1/17	0.1571144	1.0000000	0	0	5.8823529	10.8869493	CCL5
124	peptidase regulator activity (GO:0061134)	4/209	0.1576916	1.0000000	0	0	1.9138756	3.5351465	PCOLCE2;PROS1;GPC3;A2ML1
125	chloride channel activity (GO:0005254)	2/72	0.1621027	1.0000000	0	0	2.7777778	5.0542366	GABRD;CLCA4
126	lipase inhibitor activity (GO:0055102)	1/18	0.1655504	1.0000000	0	0	5.5555556	9.9915545	SCGB1A1
127	acetylcholine receptor activity (GO:0015464)	1/18	0.1655504	1.0000000	0	0	5.5555556	9.9915545	ANXA9
128	lipopolysaccharide binding (GO:0001530)	1/18	0.1655504	1.0000000	0	0	5.5555556	9.9915545	BPI
129	mannose binding (GO:0005537)	1/18	0.1655504	1.0000000	0	0	5.5555556	9.9915545	CD207
130	neurotransmitter receptor activity (GO:0030594)	2/74	0.1691769	1.0000000	0	0	2.7027027	4.8021906	NPBWR1;ANXA9
131	GABA-A receptor activity (GO:0004890)	1/19	0.1739024	1.0000000	0	0	5.2631579	9.2066381	GABRD
132	neurotransmitter:sodium symporter activity (GO:0005328)	1/19	0.1739024	1.0000000	0	0	5.2631579	9.2066381	SLC6A13
133	cofactor transporter activity (GO:0051184)	1/19	0.1739024	1.0000000	0	0	5.2631579	9.2066381	ABCG2
134	drug transporter activity (GO:0090484)	1/20	0.1821712	1.0000000	0	0	5.0000000	8.5140422	ABCG2
135	sialyltransferase activity (GO:0008373)	1/20	0.1821712	1.0000000	0	0	5.0000000	8.5140422	ST6GAL2
136	L-ascorbic acid binding (GO:0031418)	1/21	0.1903576	1.0000000	0	0	4.7619048	7.8992886	P4HA3
137	anion channel activity (GO:0005253)	2/80	0.1906887	1.0000000	0	0	2.5000000	4.1427819	GABRD;CLCA4
138	active transmembrane transporter activity (GO:0022804)	5/307	0.1945656	1.0000000	0	0	1.6286645	2.6661005	SLC5A7;SLC6A13;SLC4A10;ABCG2;SLC38A4
139	solute:cation symporter activity (GO:0015294)	2/82	0.1979403	1.0000000	0	0	2.4390244	3.9507064	SLC5A7;SLC6A13
140	chemoattractant activity (GO:0042056)	1/22	0.1984626	1.0000000	0	0	4.5454545	7.3507034	CCL5
141	phosphatidylserine binding (GO:0001786)	1/23	0.2064868	1.0000000	0	0	4.3478261	6.8587782	ANXA9
142	wide pore channel activity (GO:0022829)	1/23	0.2064868	1.0000000	0	0	4.3478261	6.8587782	GJA1
143	cytokine receptor activity (GO:0004896)	2/85	0.2088786	1.0000000	0	0	2.3529412	3.6847110	CX3CR1;LEPR
144	chloride transmembrane transporter activity (GO:0015108)	2/86	0.2125388	1.0000000	0	0	2.3255814	3.6014667	GABRD;CLCA4
145	neurotransmitter transporter activity (GO:0005326)	1/24	0.2144310	1.0000000	0	0	4.1666667	6.4156966	SLC6A13
146	anion:anion antiporter activity (GO:0015301)	1/24	0.2144310	1.0000000	0	0	4.1666667	6.4156966	SLC4A10
147	adenylyltransferase activity (GO:0070566)	1/24	0.2144310	1.0000000	0	0	4.1666667	6.4156966	OASL
148	transferase activity, transferring amino-acyl groups (GO:0016755)	1/24	0.2144310	1.0000000	0	0	4.1666667	6.4156966	TGM3
149	intracellular ligand-gated ion channel activity (GO:0005217)	1/24	0.2144310	1.0000000	0	0	4.1666667	6.4156966	CNGA1
150	dioxygenase activity (GO:0051213)	2/87	0.2162053	1.0000000	0	0	2.2988506	3.5207517	P4HA3;ALOX12
151	phospholipase activity (GO:0004620)	2/90	0.2272373	1.0000000	0	0	2.2222222	3.2928009	PLA2G1B;CCL5
152	RNA polymerase II transcription factor binding (GO:0001085)	2/90	0.2272373	1.0000000	0	0	2.2222222	3.2928009	BEX1;DUSP26
153	G-protein coupled chemoattractant receptor activity (GO:0001637)	1/26	0.2300829	1.0000000	0	0	3.8461538	5.6512139	CX3CR1
154	chemokine receptor activity (GO:0004950)	1/26	0.2300829	1.0000000	0	0	3.8461538	5.6512139	CX3CR1
155	fatty acid binding (GO:0005504)	1/26	0.2300829	1.0000000	0	0	3.8461538	5.6512139	FABP3
156	neuropeptide receptor binding (GO:0071855)	1/26	0.2300829	1.0000000	0	0	3.8461538	5.6512139	KISS1
157	MHC protein binding (GO:0042287)	1/27	0.2377921	1.0000000	0	0	3.7037037	5.3198467	CD8B
158	thyroid hormone receptor binding (GO:0046966)	1/27	0.2377921	1.0000000	0	0	3.7037037	5.3198467	OASL
159	proteoglycan binding (GO:0043394)	1/27	0.2377921	1.0000000	0	0	3.7037037	5.3198467	GPC3
160	microtubule binding (GO:0008017)	3/171	0.2446846	1.0000000	0	0	1.7543860	2.4697984	DCX;KIF12;JAKMIP2
161	phosphatidylinositol phospholipase C activity (GO:0004435)	1/28	0.2454244	1.0000000	0	0	3.5714286	5.0170219	CCL5
162	organic acid:sodium symporter activity (GO:0005343)	1/28	0.2454244	1.0000000	0	0	3.5714286	5.0170219	SLC6A13
163	alpha-tubulin binding (GO:0043014)	1/28	0.2454244	1.0000000	0	0	3.5714286	5.0170219	SNCG
164	peptidase inhibitor activity (GO:0030414)	3/173	0.2500255	1.0000000	0	0	1.7341040	2.4038017	PROS1;GPC3;A2ML1
165	phospholipase A2 activity (GO:0004623)	1/29	0.2529808	1.0000000	0	0	3.4482759	4.7394545	PLA2G1B
166	phospholipase C activity (GO:0004629)	1/30	0.2604618	1.0000000	0	0	3.3333333	4.4843302	CCL5
167	monocarboxylic acid transmembrane transporter activity (GO:0008028)	1/30	0.2604618	1.0000000	0	0	3.3333333	4.4843302	SLC6A13
168	quaternary ammonium group binding (GO:0050997)	1/31	0.2678683	1.0000000	0	0	3.2258065	4.2492255	SLC5A7
169	insulin receptor binding (GO:0005158)	1/32	0.2752010	1.0000000	0	0	3.1250000	4.0320428	DOK5
170	organic hydroxy compound transmembrane transporter activity (GO:1901618)	1/32	0.2752010	1.0000000	0	0	3.1250000	4.0320428	SLC5A7
171	peptide hormone binding (GO:0017046)	1/33	0.2824605	1.0000000	0	0	3.0303030	3.8309588	MC4R
172	lipase activity (GO:0016298)	2/105	0.2827547	1.0000000	0	0	1.9047619	2.4060489	PLA2G1B;CCL5
173	amino acid binding (GO:0016597)	2/107	0.2901569	1.0000000	0	0	1.8691589	2.3127732	DDC;ANXA9
174	peptide antigen binding (GO:0042605)	1/35	0.2967634	1.0000000	0	0	2.8571429	3.4709146	HLA-DQB2
175	scaffold protein binding (GO:0097110)	1/35	0.2967634	1.0000000	0	0	2.8571429	3.4709146	GJA1
176	carboxy-lyase activity (GO:0016831)	1/36	0.3038081	1.0000000	0	0	2.7777778	3.3093308	DDC
177	cyclic nucleotide binding (GO:0030551)	1/36	0.3038081	1.0000000	0	0	2.7777778	3.3093308	CNGA1
178	calcium-dependent phospholipid binding (GO:0005544)	1/36	0.3038081	1.0000000	0	0	2.7777778	3.3093308	ANXA9
179	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5’-phosphomonoesters (GO:0016796)	1/37	0.3107825	1.0000000	0	0	2.7027027	3.1585455	MEIOB
180	peptidase activator activity (GO:0016504)	1/37	0.3107825	1.0000000	0	0	2.7027027	3.1585455	PCOLCE2
181	oxygen binding (GO:0019825)	1/37	0.3107825	1.0000000	0	0	2.7027027	3.1585455	CYP2F1
182	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor (GO:0016616)	2/115	0.3196498	1.0000000	0	0	1.7391304	1.9835291	ADH1C;ADH1B
183	Rho GTPase activator activity (GO:0005100)	1/39	0.3245236	1.0000000	0	0	2.5641026	2.8856335	DLC1
184	protein homodimerization activity (GO:0042803)	8/653	0.3300879	1.0000000	0	0	1.2251149	1.3579128	NPPC;DMRT1;CCL5;QPRT;ANXA9;KCNK3;RUNX1T1;ABCG2
185	protein self-association (GO:0043621)	1/40	0.3312915	1.0000000	0	0	2.5000000	2.7618913	CCL5
186	inorganic anion transmembrane transporter activity (GO:0015103)	2/119	0.3342935	1.0000000	0	0	1.6806723	1.8415730	GABRD;CLCA4
187	SH3 domain binding (GO:0017124)	2/119	0.3342935	1.0000000	0	0	1.6806723	1.8415730	GJA1;SKAP1
188	phosphatidylinositol-4,5-bisphosphate binding (GO:0005546)	1/41	0.3379920	1.0000000	0	0	2.4390244	2.6456903	KCNJ1
189	growth factor receptor binding (GO:0070851)	2/121	0.3415820	1.0000000	0	0	1.6528926	1.7754835	FGF9;FGF18
190	protein kinase regulator activity (GO:0019887)	2/121	0.3415820	1.0000000	0	0	1.6528926	1.7754835	CAMK2N1;CCL5
191	receptor regulator activity (GO:0030545)	1/42	0.3446257	1.0000000	0	0	2.3809524	2.5364201	CCL5
192	neuropeptide receptor activity (GO:0008188)	1/43	0.3511932	1.0000000	0	0	2.3255814	2.4335320	NPBWR1
193	antigen binding (GO:0003823)	3/212	0.3560832	1.0000000	0	0	1.4150943	1.4612135	IGHG4;HLA-DOA;HLA-DQB2
194	cytokine activity (GO:0005125)	3/213	0.3588085	1.0000000	0	0	1.4084507	1.4436149	CCL5;SCGB3A1;SLURP1
195	3’-5’ exonuclease activity (GO:0008408)	1/45	0.3641324	1.0000000	0	0	2.2222222	2.2449725	MEIOB
196	sodium ion transmembrane transporter activity (GO:0015081)	2/128	0.3668834	1.0000000	0	0	1.5625000	1.5667361	SLC5A7;SLC6A13
197	protein tyrosine/serine/threonine phosphatase activity (GO:0008138)	1/46	0.3705054	1.0000000	0	0	2.1739130	2.1584503	DUSP26
198	chemokine activity (GO:0008009)	1/47	0.3768149	1.0000000	0	0	2.1276596	2.0765984	CCL5
199	anion:cation symporter activity (GO:0015296)	1/48	0.3830614	1.0000000	0	0	2.0833333	1.9990833	SLC6A13
200	protein heterodimerization activity (GO:0046982)	5/408	0.3869998	1.0000000	0	0	1.2254902	1.1633960	ROBO2;SCUBE1;DMRT1;JAM2;KCNK3
201	protein kinase activator activity (GO:0030295)	1/49	0.3892456	1.0000000	0	0	2.0408163	1.9256015	CCL5
202	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors (GO:0016706)	1/49	0.3892456	1.0000000	0	0	2.0408163	1.9256015	P4HA3
203	SH3/SH2 adaptor activity (GO:0005070)	1/50	0.3953682	1.0000000	0	0	2.0000000	1.8558758	SKAP1
204	carbon-carbon lyase activity (GO:0016830)	1/51	0.4014296	1.0000000	0	0	1.9607843	1.7896531	DDC
205	kinase regulator activity (GO:0019207)	2/141	0.4128121	1.0000000	0	0	1.4184397	1.2549827	CAMK2N1;CCL5
206	double-stranded RNA binding (GO:0003725)	1/53	0.4133717	1.0000000	0	0	1.8867925	1.6668075	OASL
207	transferase activity, transferring pentosyl groups (GO:0016763)	1/53	0.4133717	1.0000000	0	0	1.8867925	1.6668075	QPRT
208	modified amino acid binding (GO:0072341)	1/53	0.4133717	1.0000000	0	0	1.8867925	1.6668075	ANXA9
209	protein kinase inhibitor activity (GO:0004860)	1/54	0.4192536	1.0000000	0	0	1.8518519	1.6097765	CAMK2N1
210	kinase activator activity (GO:0019209)	1/55	0.4250768	1.0000000	0	0	1.8181818	1.5554281	CCL5
211	repressing transcription factor binding (GO:0070491)	1/55	0.4250768	1.0000000	0	0	1.8181818	1.5554281	HLA-DQB2
212	phosphatidylinositol bisphosphate binding (GO:1902936)	1/56	0.4308418	1.0000000	0	0	1.7857143	1.5035968	KCNJ1
213	oxidoreductase activity, acting on the CH-CH group of donors (GO:0016627)	1/56	0.4308418	1.0000000	0	0	1.7857143	1.5035968	ACOXL
214	steroid hormone receptor activity (GO:0003707)	1/57	0.4365494	1.0000000	0	0	1.7543860	1.4541294	OR51E2
215	pyridoxal phosphate binding (GO:0030170)	1/57	0.4365494	1.0000000	0	0	1.7543860	1.4541294	DDC
216	chemokine receptor binding (GO:0042379)	1/57	0.4365494	1.0000000	0	0	1.7543860	1.4541294	CCL5
217	kinase inhibitor activity (GO:0019210)	1/57	0.4365494	1.0000000	0	0	1.7543860	1.4541294	CAMK2N1
218	deoxyribonuclease activity (GO:0004536)	1/57	0.4365494	1.0000000	0	0	1.7543860	1.4541294	MEIOB
219	antiporter activity (GO:0015297)	1/62	0.4642441	1.0000000	0	0	1.6129032	1.2376529	SLC4A10
220	cargo receptor activity (GO:0038024)	1/62	0.4642441	1.0000000	0	0	1.6129032	1.2376529	LRP1B
221	hormone binding (GO:0042562)	1/62	0.4642441	1.0000000	0	0	1.6129032	1.2376529	MC4R
222	hormone receptor binding (GO:0051427)	2/160	0.4768118	1.0000000	0	0	1.2500000	0.9257918	NPPC;OASL
223	transmembrane receptor protein tyrosine kinase activity (GO:0004714)	1/65	0.4802063	1.0000000	0	0	1.5384615	1.1285222	FLT4
224	growth factor activity (GO:0008083)	2/163	0.4865301	1.0000000	0	0	1.2269939	0.8839957	FGF9;FGF18
225	signaling adaptor activity (GO:0035591)	1/67	0.4905840	1.0000000	0	0	1.4925373	1.0629235	SKAP1
226	extracellular matrix structural constituent (GO:0005201)	1/68	0.4956953	1.0000000	0	0	1.4705882	1.0320498	FBN1
227	endopeptidase inhibitor activity (GO:0004866)	2/166	0.4961360	1.0000000	0	0	1.2048193	0.8444640	PROS1;A2ML1
228	endopeptidase regulator activity (GO:0061135)	2/171	0.5118910	1.0000000	0	0	1.1695906	0.7832088	PROS1;A2ML1
229	peptide binding (GO:0042277)	2/172	0.5150033	1.0000000	0	0	1.1627907	0.7716070	MC4R;HLA-DQB2
230	core promoter proximal region sequence-specific DNA binding (GO:0000987)	2/176	0.5273210	1.0000000	0	0	1.1363636	0.7272111	DMRT1;FEZF2
231	exonuclease activity (GO:0004527)	1/75	0.5300734	1.0000000	0	0	1.3333333	0.8463198	MEIOB
232	amide binding (GO:0033218)	2/177	0.5303674	1.0000000	0	0	1.1299435	0.7165935	MC4R;HLA-DQB2
233	core promoter proximal region DNA binding (GO:0001159)	2/178	0.5334006	1.0000000	0	0	1.1235955	0.7061602	DMRT1;FEZF2
234	single-stranded DNA binding (GO:0003697)	1/76	0.5347903	1.0000000	0	0	1.3157895	0.8235271	MEIOB
235	microtubule motor activity (GO:0003777)	1/78	0.5440833	1.0000000	0	0	1.2820513	0.7803242	KIF12
236	small conjugating protein ligase binding (GO:0044389)	2/182	0.5453994	1.0000000	0	0	1.0989011	0.6661944	MC4R;HLA-DQB2
237	ubiquitin protein ligase binding (GO:0031625)	2/182	0.5453994	1.0000000	0	0	1.0989011	0.6661944	MC4R;HLA-DQB2
238	vitamin binding (GO:0019842)	1/80	0.5531916	1.0000000	0	0	1.2500000	0.7400636	P4HA3
239	protein transporter activity (GO:0008565)	1/81	0.5576776	1.0000000	0	0	1.2345679	0.7209558	RAMP2
240	acid-amino acid ligase activity (GO:0016881)	1/81	0.5576776	1.0000000	0	0	1.2345679	0.7209558	UBE2QL1
241	glycoprotein binding (GO:0001948)	1/81	0.5576776	1.0000000	0	0	1.2345679	0.7209558	GPC3
242	transmembrane receptor protein kinase activity (GO:0019199)	1/82	0.5621188	1.0000000	0	0	1.2195122	0.7024903	FLT4
243	steroid binding (GO:0005496)	1/82	0.5621188	1.0000000	0	0	1.2195122	0.7024903	PLA2G1B
244	lipid transporter activity (GO:0005319)	1/87	0.5836680	1.0000000	0	0	1.1494253	0.6188770	FABP3
245	endopeptidase activity (GO:0004175)	4/411	0.5909584	1.0000000	0	0	0.9732360	0.5119315	TMPRSS11A;PRSS27;TMPRSS11E;TMPRSS11F
246	alcohol binding (GO:0043178)	1/89	0.5919892	1.0000000	0	0	1.1235955	0.5890639	SLC5A7
247	phosphoric diester hydrolase activity (GO:0008081)	1/90	0.5960875	1.0000000	0	0	1.1111111	0.5748531	CCL5
248	phosphatidylinositol phosphate binding (GO:1901981)	1/91	0.6001449	1.0000000	0	0	1.0989011	0.5610815	KCNJ1
249	PDZ domain binding (GO:0030165)	1/96	0.6198314	1.0000000	0	0	1.0416667	0.4982372	GJA1
250	serine-type endopeptidase inhibitor activity (GO:0004867)	1/98	0.6274332	1.0000000	0	0	1.0204082	0.4756306	A2ML1
251	unfolded protein binding (GO:0051082)	1/101	0.6385533	1.0000000	0	0	0.9900990	0.4441090	SCG5
252	integrin binding (GO:0005178)	1/102	0.6421861	1.0000000	0	0	0.9803922	0.4341933	ECM2
253	protein tyrosine phosphatase activity (GO:0004725)	1/103	0.6457826	1.0000000	0	0	0.9708738	0.4245557	DUSP26
254	ATPase activity, coupled to transmembrane movement of substances (GO:0042626)	1/104	0.6493431	1.0000000	0	0	0.9615385	0.4151866	ABCG2
255	ATPase activity, coupled to movement of substances (GO:0043492)	1/105	0.6528680	1.0000000	0	0	0.9523810	0.4060766	ABCG2
256	calcium channel activity (GO:0005262)	1/108	0.6632325	1.0000000	0	0	0.9259259	0.3802127	GPM6A
257	hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances (GO:0016820)	1/108	0.6632325	1.0000000	0	0	0.9259259	0.3802127	ABCG2
258	double-stranded DNA binding (GO:0003690)	1/109	0.6666184	1.0000000	0	0	0.9174312	0.3720527	HLF
259	G-protein coupled receptor binding (GO:0001664)	2/229	0.6700506	1.0000000	0	0	0.8733624	0.3496962	KISS1;CCL5
260	primary active transmembrane transporter activity (GO:0015399)	1/111	0.6732890	1.0000000	0	0	0.9009009	0.3563789	ABCG2
261	P-P-bond-hydrolysis-driven transmembrane transporter activity (GO:0015405)	1/111	0.6732890	1.0000000	0	0	0.9009009	0.3563789	ABCG2
262	carboxylic ester hydrolase activity (GO:0052689)	1/111	0.6732890	1.0000000	0	0	0.9009009	0.3563789	PLA2G1B
263	transcription factor binding (GO:0008134)	4/464	0.6851836	1.0000000	0	0	0.8620690	0.3259211	BEX1;DUSP26;HLA-DQB2;OASL
264	ligase activity, forming carbon-nitrogen bonds (GO:0016879)	1/117	0.6925144	1.0000000	0	0	0.8547009	0.3140395	UBE2QL1
265	structure-specific DNA binding (GO:0043566)	2/241	0.6971041	1.0000000	0	0	0.8298755	0.2994361	HLF;MEIOB
266	hormone activity (GO:0005179)	1/122	0.7076726	1.0000000	0	0	0.8196721	0.2834211	NPPC
267	growth factor binding (GO:0019838)	1/123	0.7106138	1.0000000	0	0	0.8130081	0.2777449	FLT4
268	receptor signaling protein activity (GO:0005057)	1/124	0.7135255	1.0000000	0	0	0.8064516	0.2722073	DOK5
269	Ras GTPase activator activity (GO:0005099)	1/124	0.7135255	1.0000000	0	0	0.8064516	0.2722073	DLC1
270	kinase binding (GO:0019900)	4/487	0.7210317	1.0000000	0	0	0.8213552	0.2686424	CAMK2N1;DCX;SKAP1;JAKMIP2
271	calcium ion transmembrane transporter activity (GO:0015085)	1/127	0.7220870	1.0000000	0	0	0.7874016	0.2563855	GPM6A
272	motor activity (GO:0003774)	1/132	0.7357941	1.0000000	0	0	0.7575758	0.2324280	KIF12
273	protein binding, bridging (GO:0030674)	1/134	0.7410867	1.0000000	0	0	0.7462687	0.2236102	SKAP1
274	cofactor binding (GO:0048037)	2/266	0.7475973	1.0000000	0	0	0.7518797	0.2187149	DDC;HHIP
275	nuclear hormone receptor binding (GO:0035257)	1/139	0.7538610	1.0000000	0	0	0.7194245	0.2032714	OASL
276	nucleotidyltransferase activity (GO:0016779)	1/140	0.7563396	1.0000000	0	0	0.7142857	0.1994748	OASL
277	protein tyrosine kinase activity (GO:0004713)	1/142	0.7612226	1.0000000	0	0	0.7042254	0.1921334	FLT4
278	binding, bridging (GO:0060090)	1/146	0.7706983	1.0000000	0	0	0.6849315	0.1783961	SKAP1
279	transferase activity, transferring glycosyl groups (GO:0016757)	2/280	0.7726084	1.0000000	0	0	0.7142857	0.1842735	ST6GAL2;QPRT
280	guanyl ribonucleotide binding (GO:0032561)	3/405	0.7735836	1.0000000	0	0	0.7407407	0.1901641	DIRAS2;SCG5;CNGA1
281	guanyl nucleotide binding (GO:0019001)	3/406	0.7750152	1.0000000	0	0	0.7389163	0.1883295	DIRAS2;SCG5;CNGA1
282	divalent inorganic cation transmembrane transporter activity (GO:0072509)	1/154	0.7885417	1.0000000	0	0	0.6493506	0.1542663	GPM6A
283	phospholipid binding (GO:0005543)	2/296	0.7985326	1.0000000	0	0	0.6756757	0.1520132	ANXA9;KCNJ1
284	isomerase activity (GO:0016853)	1/159	0.7989850	1.0000000	0	0	0.6289308	0.1411403	ALOX12
285	protein C-terminus binding (GO:0008022)	1/162	0.8050029	1.0000000	0	0	0.6172840	0.1338947	KCNK3
286	RNA polymerase II core promoter proximal region sequence-specific DNA binding (GO:0000978)	1/167	0.8146371	1.0000000	0	0	0.5988024	0.1227620	FEZF2
287	protein kinase binding (GO:0019901)	3/437	0.8158405	1.0000000	0	0	0.6864989	0.1397275	CAMK2N1;DCX;SKAP1
288	cell adhesion molecule binding (GO:0050839)	1/168	0.8165063	1.0000000	0	0	0.5952381	0.1206671	ECM2
289	phosphoprotein phosphatase activity (GO:0004721)	1/172	0.8237975	1.0000000	0	0	0.5813953	0.1126922	DUSP26
290	cysteine-type peptidase activity (GO:0008234)	1/172	0.8237975	1.0000000	0	0	0.5813953	0.1126922	CTSW
291	enzyme activator activity (GO:0008047)	3/446	0.8264580	1.0000000	0	0	0.6726457	0.1282104	PCOLCE2;DLC1;CCL5
292	lyase activity (GO:0016829)	1/177	0.8325073	1.0000000	0	0	0.5649718	0.1035668	DDC
293	phosphatidylinositol binding (GO:0035091)	1/178	0.8341972	1.0000000	0	0	0.5617978	0.1018458	KCNJ1
294	metallopeptidase activity (GO:0008237)	1/188	0.8501902	1.0000000	0	0	0.5319149	0.0863272	ADAMTSL1
295	transcription regulatory region sequence-specific DNA binding (GO:0000976)	2/340	0.8568359	1.0000000	0	0	0.5882353	0.0908876	DMRT1;FEZF2
296	nuclease activity (GO:0004518)	1/195	0.8604625	1.0000000	0	0	0.5128205	0.0770693	MEIOB
297	small GTPase regulator activity (GO:0005083)	1/195	0.8604625	1.0000000	0	0	0.5128205	0.0770693	DLC1
298	phosphoric ester hydrolase activity (GO:0042578)	2/360	0.8778898	1.0000000	0	0	0.5555556	0.0723523	CCL5;DUSP26
299	GTP binding (GO:0005525)	2/385	0.9002020	1.0000000	0	0	0.5194805	0.0546161	DIRAS2;SCG5
300	cytokine receptor binding (GO:0005126)	1/228	0.9002045	1.0000000	0	0	0.4385965	0.0461111	CCL5
301	ATPase activity (GO:0016887)	2/395	0.9080188	1.0000000	0	0	0.5063291	0.0488558	KIF12;ABCG2
302	transferase activity, transferring acyl groups (GO:0016746)	1/243	0.9143243	1.0000000	0	0	0.4115226	0.0368601	TGM3
303	chromatin binding (GO:0003682)	2/420	0.9251344	1.0000000	0	0	0.4761905	0.0370554	DMRT1;MEIOB
304	GTPase activator activity (GO:0005096)	1/265	0.9315150	1.0000000	0	0	0.3773585	0.0267709	DLC1
305	phosphatase activity (GO:0016791)	1/266	0.9322090	1.0000000	0	0	0.3759398	0.0263903	DUSP26
306	ATPase activity, coupled (GO:0042623)	1/272	0.9362286	1.0000000	0	0	0.3676471	0.0242263	ABCG2
307	zinc ion binding (GO:0008270)	8/1256	0.9391936	1.0000000	0	0	0.6369427	0.0399577	ADAMTSL1;APOBEC2;ADH1C;APOBEC3H;ADH1B;HHIP;PEG10;ZNF385B
308	RNA polymerase II regulatory region sequence-specific DNA binding (GO:0000977)	1/284	0.9435701	1.0000000	0	0	0.3521127	0.0204523	FEZF2
309	RNA polymerase II regulatory region DNA binding (GO:0001012)	1/288	0.9458253	1.0000000	0	0	0.3472222	0.0193394	FEZF2
310	GTPase regulator activity (GO:0030695)	1/310	0.9567174	1.0000000	0	0	0.3225806	0.0142733	DLC1
311	nucleoside-triphosphatase regulator activity (GO:0060589)	1/330	0.9647144	1.0000000	0	0	0.3030303	0.0108858	DLC1
312	olfactory receptor activity (GO:0004984)	1/420	0.9859630	1.0000000	0	0	0.2380952	0.0033658	OR51E2
313	ligase activity (GO:0016874)	1/431	0.9874621	1.0000000	0	0	0.2320186	0.0029274	UBE2QL1
314	ATP binding (GO:0005524)	6/1494	0.9978601	1.0000000	0	0	0.4016064	0.0008603	FLT4;UBE2QL1;KIF12;KCNJ1;ABCG2;OASL

Reproducibility

For reproducibility:

## datetime

Sys.time()

## [1] "2020-12-08 14:37:05 EST"

## session info

sessionInfo()

## R version 4.0.2 (2020-06-22)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: CentOS Linux 7 (Core)
## 
## Matrix products: default
## BLAS:   /share/pkg.7/r/4.0.2/install/lib/libopenblasp-r0.3.7.so
## LAPACK: /share/pkg.7/r/4.0.2/install/lib/liblapack.so.3.9.0
## 
## locale:
## [1] C
## 
## attached base packages:
## [1] parallel  stats4    stats     graphics  grDevices utils     datasets 
## [8] methods   base     
## 
## other attached packages:
##  [1] limma_3.46.0                affy_1.68.0                
##  [3] biomaRt_2.46.0              enrichR_2.1                
##  [5] kableExtra_1.3.1            knitr_1.30                 
##  [7] DESeq2_1.30.0               RColorBrewer_1.1-2         
##  [9] pheatmap_1.0.12             ggplot2_3.3.2              
## [11] dplyr_1.0.2                 readxl_1.3.1               
## [13] SummarizedExperiment_1.20.0 Biobase_2.50.0             
## [15] GenomicRanges_1.42.0        GenomeInfoDb_1.26.0        
## [17] IRanges_2.24.0              S4Vectors_0.28.0           
## [19] BiocGenerics_0.36.0         MatrixGenerics_1.2.0       
## [21] matrixStats_0.57.0          plyr_1.8.6                 
## [23] rmarkdown_2.5              
## 
## loaded via a namespace (and not attached):
##  [1] bitops_1.0-6           bit64_4.0.5            webshot_0.5.2         
##  [4] progress_1.2.2         httr_1.4.2             tools_4.0.2           
##  [7] R6_2.5.0               affyio_1.60.0          DBI_1.1.0             
## [10] colorspace_2.0-0       withr_2.3.0            tidyselect_1.1.0      
## [13] prettyunits_1.1.1      bit_4.0.4              curl_4.3              
## [16] compiler_4.0.2         preprocessCore_1.52.0  rvest_0.3.6           
## [19] xml2_1.3.2             DelayedArray_0.16.0    labeling_0.4.2        
## [22] scales_1.1.1           genefilter_1.72.0      askpass_1.1           
## [25] rappdirs_0.3.1         stringr_1.4.0          digest_0.6.27         
## [28] XVector_0.30.0         pkgconfig_2.0.3        htmltools_0.5.0       
## [31] dbplyr_2.0.0           highr_0.8              rlang_0.4.8           
## [34] rstudioapi_0.13        RSQLite_2.2.1          farver_2.0.3          
## [37] generics_0.1.0         BiocParallel_1.24.1    RCurl_1.98-1.2        
## [40] magrittr_2.0.1         GenomeInfoDbData_1.2.4 Matrix_1.2-18         
## [43] Rcpp_1.0.5             munsell_0.5.0          lifecycle_0.2.0       
## [46] stringi_1.5.3          yaml_2.2.1             zlibbioc_1.36.0       
## [49] BiocFileCache_1.14.0   grid_4.0.2             blob_1.2.1            
## [52] crayon_1.3.4           lattice_0.20-41        splines_4.0.2         
## [55] annotate_1.68.0        hms_0.5.3              locfit_1.5-9.4        
## [58] pillar_1.4.6           rjson_0.2.20           geneplotter_1.68.0    
## [61] XML_3.99-0.5           glue_1.4.2             evaluate_0.14         
## [64] BiocManager_1.30.10    vctrs_0.3.5            cellranger_1.1.0      
## [67] gtable_0.3.0           openssl_1.4.3          purrr_0.3.4           
## [70] assertthat_0.2.1       xfun_0.19              xtable_1.8-4          
## [73] survival_3.1-12        viridisLite_0.3.0      tibble_3.0.4          
## [76] AnnotationDbi_1.52.0   memoise_1.1.0          ellipsis_0.3.1