Preprocessing

Based off of prior QC (“20201025_DECAMP2_Novartis_QC_Bronch.Rmd”), we have identified several poor quality samples. We will remove these samples prior to any downstream analysis.

# Load library:
library(plyr)
library(SummarizedExperiment)
library(readxl)
library(dplyr)
library(ggplot2)
library(pheatmap)
library("RColorBrewer")
library(DESeq2)
library(knitr)
library(kableExtra)
library(enrichR)
library(biomaRt)
library(affy)
library(limma)

set.seed("12345")

# Load data:
se <- readRDS("/restricted/projectnb/pulmseq/Novartis/processing/work/28/da9dcb4ebb5f902c53fff1bc1ebdc2/Novartis_Gene_Expression.rds")
colnames(se) <- gsub(pattern = "_.*", "", colnames(se))

# Load annotation:

# Matches sample ID to kitnumber + Has batch info
annotManifest <- read_excel("/restricted/projectnb/pulmseq/Novartis/annotation/Novartis_RNASeq_run_manifest.xlsx")

# Matches sample ID to sample type/RIN (received from Jack, 8/24/20)
annotSampleEM0 <- read_excel("/restricted/projectnb/camplab/home/ykoga07/DECAMP/Novartis/Data/Annotation/RNA_data_for_Yusuke_08_24_20.xlsx", sheet = "EM0", skip = 2)

annotSampleEM5 <- read_excel("/restricted/projectnb/camplab/home/ykoga07/DECAMP/Novartis/Data/Annotation/RNA_data_for_Yusuke_08_24_20.xlsx", sheet = "EM5", skip = 2)

annotSampleEM6 <- read_excel("/restricted/projectnb/camplab/home/ykoga07/DECAMP/Novartis/Data/Annotation/RNA_data_for_Yusuke_08_24_20.xlsx", sheet = "EM6", skip = 2)

annotSampleEM8 <- read_excel("/restricted/projectnb/camplab/home/ykoga07/DECAMP/Novartis/Data/Annotation/RNA_data_for_Yusuke_08_24_20.xlsx", sheet = "EM8", skip = 3)

annotSampleEM15 <- read_excel("/restricted/projectnb/camplab/home/ykoga07/DECAMP/Novartis/Data/Annotation/RNA_data_for_Yusuke_08_24_20.xlsx", sheet = "EM15", skip = 3)

annotSampleEM16 <- read_excel("/restricted/projectnb/camplab/home/ykoga07/DECAMP/Novartis/Data/Annotation/RNA_data_for_Yusuke_08_24_20.xlsx", sheet = "EM16", skip = 3)

annotSampleN1 <- read_excel("/restricted/projectnb/camplab/home/ykoga07/DECAMP/Novartis/Data/Annotation/RNA_data_for_Yusuke_08_24_20.xlsx", sheet = "N1", skip = 3)

annotSampleN2 <- read_excel("/restricted/projectnb/camplab/home/ykoga07/DECAMP/Novartis/Data/Annotation/RNA_data_for_Yusuke_08_24_20.xlsx", sheet = "N2", skip = 3)

# Combine Jack's sample-based annotation file into one dataframe
annotSampleEM0 <- annotSampleEM0[, c(
  "RNA Sample ID", "DECAMP #",
  "Sample ID", "Kit Number", "Original Sample Type",
  "Isolation Date", "RIN", "DV200 (%)"
)]
colnames(annotSampleEM0) <- c(
  "RNA Sample ID", "DECAMP #",
  "Sample ID", "Kit Number", "Sample Type",
  "Isolation Date", "RIN", "DV200 (%)"
)

annotSampleEM5 <- annotSampleEM5[, c(
  "RNA Sample ID", "DECAMP #",
  "Patient ID", "Patient ID", "Sample Type",
  "Isolation Date", "RIN", "DV200 (%)"
)]
colnames(annotSampleEM5) <- c(
  "RNA Sample ID", "DECAMP #",
  "Sample ID", "Kit Number", "Sample Type",
  "Isolation Date", "RIN", "DV200 (%)"
)

annotSampleEM6 <- annotSampleEM6[, c(
  "RNA Sample ID", "DECAMP #",
  "Sample ID", "Kit Number", "Sample Type",
  "Isolation Date", "RIN", "DV200 (%)"
)]
colnames(annotSampleEM6) <- c(
  "RNA Sample ID", "DECAMP #",
  "Sample ID", "Kit Number", "Sample Type",
  "Isolation Date", "RIN", "DV200 (%)"
)

annotSampleEM8 <- annotSampleEM8[, c(
  "RNA Sample ID", "DECAMP #",
  "Sample ID", "Original Sample ID", "Sample Type",
  "Isolation Date", "RIN", "DV200 (%)"
)]
colnames(annotSampleEM8) <- c(
  "RNA Sample ID", "DECAMP #",
  "Sample ID", "Kit Number", "Sample Type",
  "Isolation Date", "RIN", "DV200 (%)"
)

annotSampleEM15 <- annotSampleEM15[, c(
  "RNA Sample ID", "DECAMP #",
  "Sample ID", "Kit Number", "Sample Type",
  "Isolation Date", "RIN", "DV200 (%)"
)]
colnames(annotSampleEM15) <- c(
  "RNA Sample ID", "DECAMP #",
  "Sample ID", "Kit Number", "Sample Type",
  "Isolation Date", "RIN", "DV200 (%)"
)

annotSampleEM16 <- annotSampleEM16[, c(
  "RNA Sample ID", "DECAMP #",
  "Sample ID", "Kit Number", "Sample Type",
  "Isolation Date", "RIN", "DV200 (%)"
)]
colnames(annotSampleEM16) <- c(
  "RNA Sample ID", "DECAMP #",
  "Sample ID", "Kit Number", "Sample Type",
  "Isolation Date", "RIN", "DV200 (%)"
)

annotSampleN1 <- annotSampleN1[, c(
  "RNA Sample ID", "DECAMP #",
  "Sample ID", "Kit Number", "Sample Type",
  "Isolation Date", "RIN", "DV200 (%)"
)]
colnames(annotSampleN1) <- c(
  "RNA Sample ID", "DECAMP #",
  "Sample ID", "Kit Number", "Sample Type",
  "Isolation Date", "RIN", "DV200 (%)"
)

annotSampleN2 <- annotSampleN2[, c(
  "RNA Sample ID", "DECAMP #",
  "Sample ID", "Kit Number", "Sample Type",
  "Isolation Date", "RIN", "DV200 (%)"
)]
colnames(annotSampleN2) <- c(
  "RNA Sample ID", "DECAMP #",
  "Sample ID", "Kit Number", "Sample Type",
  "Isolation Date", "RIN", "DV200 (%)"
)

allAnnotSamples <- ls()[grep("annotSample", ls())]
annotSample <- as.data.frame(matrix(ncol = 8))
colnames(annotSample) <- c(
  "RNA Sample ID", "DECAMP #",
  "Sample ID", "Kit Number", "Sample Type",
  "Isolation Date", "RIN", "DV200 (%)"
)
# Combine
for (x in allAnnotSamples) {
  annotSamples <- get(x)
  annotSamples$`Isolation Date` <- as.character(annotSamples$`Isolation Date`)
  annotSample <- rbind(annotSample, annotSamples)
}
annotSample <- annotSample[-which(is.na(annotSample$`RNA Sample ID`)), ]
annotSample <- annotSample[-which(is.na(annotSample$`Sample Type`)), ]

annotSample <- annotSample[-which(duplicated(annotSample$`RNA Sample ID`)), ]

# Save which samples had wrong rRNA peak when checking RIN
wrongRRNA.ix <- grep(pattern = "rong rRNA peak", annotSample$RIN)
annotSample$wrongRNAPeak <- 0
annotSample$wrongRNAPeak[wrongRRNA.ix] <- 1

# Edit RIN section to convert into numeric vector
annotSample$RIN <- gsub(pattern = "(wrong rRNA peak)", replacement = "", annotSample$RIN, fixed = TRUE)
annotSample$RIN <- gsub(pattern = "(wrong RNA peak)", replacement = "", annotSample$RIN, fixed = TRUE)
annotSample$RIN <- gsub(pattern = "(wrong rRNA peaks)", replacement = "", annotSample$RIN, fixed = TRUE)
annotSample$RIN <- gsub(pattern = "(Wrong rRNA peak)", replacement = "", annotSample$RIN, fixed = TRUE)
annotSample$RIN <- gsub(pattern = "(Wrong rRNA peaks)", replacement = "", annotSample$RIN, fixed = TRUE)
annotSample$RIN <- gsub(pattern = "\\/NA", replacement = "", annotSample$RIN)
annotSample$RIN <- gsub(pattern = ".*\\/", replacement = "", annotSample$RIN)
annotSample$RIN <- as.numeric(annotSample$RIN)
# There is a "29", probably 2.9, will ask Jack
annotSample$RIN[annotSample$RIN == 29] <- 2.9

# Consolidate nasal/bronch terms
annotSample$`Sample Type` <- gsub(pattern = ".*Bronch.*", replacement = "Bronchial Brushings", annotSample$`Sample Type`)
annotSample$`Sample Type` <- gsub(pattern = ".*Nasal.*", replacement = "Nasal Brushings", annotSample$`Sample Type`)

annotManifest <- filter(annotManifest, Run == "Run 1")
annotSample <- annotSample[annotSample$`RNA Sample ID` %in% annotManifest$Sample, ]
annotSample <- annotSample[match(annotSample$`RNA Sample ID`, annotManifest$Sample), ]

# Removing duplicate column
annotManifest$`Kit Number` <- NULL

annot <- cbind(annotManifest, annotSample)

# Clinical info:

# Matches kitnumber to randID, "Novartis_datadump"
annotDataDump2 <- read_excel("/restricted/projectnb/decamp/annotation/20200920/FullDECAMP2_DataDump_20200920.xlsx", sheet = "_D2CASEMAP", )

# randID to demographics info, "Novartis_datadump"
annotDataDump3 <- read_excel("/restricted/projectnb/decamp/annotation/20200920/FullDECAMP2_DataDump_20200920.xlsx", sheet = "_D2DEMO")

# randID to age/smoking info, "Novartis_datadump"
annotDataDump4 <- read_excel("/restricted/projectnb/decamp/annotation/20200920/FullDECAMP2_DataDump_20200920.xlsx", sheet = "_D2ELIGCHECK")

# randID to FEV/FVC, "Novartis_datadump"
annotDataDump5 <- read_excel("/restricted/projectnb/decamp/annotation/20200920/FullDECAMP2_DataDump_20200920.xlsx", sheet = "_D2PFT")
annotDataDump5 <- filter(annotDataDump5, timepoint == "Baseline Visit")

# Combine annotation info
annotA <- merge(merge(annotDataDump2, annotDataDump3, by.x = "randID", by.y = "randID"), annotDataDump4, by.x = "randID", by.y = "randID")
annotA <- merge(annotA, annotDataDump5, by.x = "randID", by.y = "randID")

# Removing patient "4796-053" as "Pacific Islander" for time being
annotA <- annotA[!(duplicated(annotA$randID)), ]

annot <- merge(annot, annotA, by.x = "Kit Number", by.y = "kitnumber", all.x = TRUE)

annotBronch <- annot[annot$`Sample Type` == "Bronchial Brushings", ]
annotNasal <- annot[annot$`Sample Type` == "Nasal Brushings", ]

uniquePatients <- length(unique(annot$`Kit Number`))

numBronch <- length(unique(annotBronch$Sample))
numNasal <- length(unique(annotNasal$Sample))

bothBronchNasal <- length(intersect(annotBronch$`Kit Number`, annotNasal$`Kit Number`))

#Steiling signature genes
steilingGenes <- read_excel("/restricted/projectnb/camplab/home/ykoga07/DECAMP/Novartis/Analysis/1stPass/Steiling_2013_Genelist.xlsx", sheet = "GeneList", col_names = FALSE)

There are 280 samples and 201 unique patients in the dataset. 80 are nasal samples. There are 79 patients that have both bronchial and nasal samples.

# Samples flagged by Novartis as poor quality:
# flaggedByNovartis <- c(
#   "EM15-14", "EM15-31", "EM15-64", "EM15-85", "EM16-194", "EM16-195",
#   "EM16-228", "EM5-100", "EM8-112", "EM8-130", "EM8-158", "EM8-171",
#   "EM8-26", "EM8-55", "EM8-66", "N1-115", "N1-119", "N1-125",
#   "N1-139", "N1-25", "N1-40", "N1-55", "N1-63", "N1-64",
#   "N1-67", "N1-81", "N1-83", "N1-84", "N1-94", "N2-10",
#   "N2-15", "N2-18", "N2-30", "N2-31", "N2-22", "N2-28"
# )

poorQuality <- read.table("/restricted/projectnb/camplab/home/ykoga07/DECAMP/Novartis/Analysis/QC/20201026_PoorQuality_Bronch.txt")

seBronch <- se[, which(colnames(se) %in% annotBronch$`RNA Sample ID`)]
orig.num.samples <- ncol(seBronch) 

#Remove:
seBronch <- seBronch[,!colnames(seBronch) %in% poorQuality$x]
filt.num.samples <- ncol(seBronch) 

annotBronch <- annotBronch[annotBronch$`RNA Sample ID` %in% colnames(se), ]

# reorder
annotBronch <- annotBronch[match(colnames(seBronch), annotBronch$`RNA Sample ID`), ]

coldataBronch <- colData(seBronch)
annotBronch$TIN <- colData(seBronch)$RSeQC_TIN_mean

Originally, there were 200 samples. Upon filtering, we will use 173 samples for downstream analysis.

counts <- assay(seBronch)
rownames(counts) <- rowRanges(seBronch)$external_gene_id

counts <- apply(counts, 1:2, function(x) {
  return(as.integer(x))
})

# arglist <- list(x=annotBronch$FEV_RS_PER,y=annotBronch$FEV_FVC)
# statusfxn <- function(x,y) {
#   if (x < 80 && y < 0.7) {
#     return("COPD")
#   } else {
#     return("NO_COPD")
#   }
# }
# copd.status <- sapply(arglist, statusfxn, x = x, y = y)

copd.status <- c()
for(x in 1:nrow(annotBronch)){
  if(annotBronch[x, "FEV_RS_PER"] < 80 && 
     annotBronch[x, "FEV_FVC"] < 0.7){
        copd.status <- c(copd.status, "COPD")
  }else{
       copd.status <- c(copd.status, "NO_COPD")
     }
}

annotBronch$COPD_status <- as.factor(copd.status)

annotBronch$GRPB_SMK_STS <- gsub(" ", "_", annotBronch$GRPB_SMK_STS)

no.smk.status.ix <- which(is.na(annotBronch$GRPB_SMK_STS))

counts <- counts[, -no.smk.status.ix]
annotBronch <- annotBronch[-no.smk.status.ix, ]

2 samples were removed due to lack of smoker status.

Clinical annotation

General annotation data of patients were compared between those of which samples of FEV1 predicted < 80 (COPD) and FEV1 predicted > 80 (NO COPD).

#Rename race
annotBronch$RACE_CAT_TXT <- gsub("Unknown","Not Reported",annotBronch$RACE_CAT_TXT)
annotBronch$RACE_CAT_TXT <- gsub("Black or Afr. American",
                                 "Black/African American",annotBronch$RACE_CAT_TXT)
annotBronch$RACE_CAT_TXT <- gsub("Native Hawaiian or Other Pacific Islander",
                                 "Pacific Islander",annotBronch$RACE_CAT_TXT)
annotBronch$RACE_CAT_TXT <- gsub("American Indian or Alaska Native",
                                 "Native American",annotBronch$RACE_CAT_TXT)
annotBronch$RACE_CAT_TXT <- as.factor(annotBronch$RACE_CAT_TXT)

annotBronch_COPD <- annotBronch[annotBronch$COPD_status == "COPD", ]

annotBronch_NO_COPD <- annotBronch[annotBronch$COPD_status == "NO_COPD", ]

lab <- c(
  rep("Retained", length(annotBronch_COPD$GRPB_SMK_STS)),
  rep("Removed", length(annotBronch_NO_COPD$GRPB_SMK_STS))
)
# AGE
mean.age <- mean(annotBronch_COPD$AGE)
sd.age <- sd(annotBronch_COPD$AGE)

age <- paste0(signif(mean.age, 3), " +/- ", signif(sd.age, 3))

mean.age.rm <- mean(annotBronch_NO_COPD$AGE)
sd.age.rm <- sd(annotBronch_NO_COPD$AGE)

age.rm <- paste0(signif(mean.age.rm, 3), " +/- ", signif(sd.age.rm, 3))

age.pvalue <- signif(wilcox.test(annotBronch_COPD$AGE, annotBronch_NO_COPD$AGE)$p.value, 3)

demo.table <- c(age, age.rm, age.pvalue)

# Gender
gstatus <- c(annotBronch_COPD$PERSON_GENDER, annotBronch_NO_COPD$PERSON_GENDER)

male.ct <- sum(annotBronch_COPD$PERSON_GENDER == "Male Gender")
male.pct <- signif(male.ct / length(annotBronch_COPD$PERSON_GENDER), 3) * 100
male <- paste0("Male: ", male.ct, "(", male.pct, "%)")

male.ct.rm <- sum(annotBronch_NO_COPD$PERSON_GENDER == "Male Gender")
male.pct.rm <- signif(male.ct.rm / length(annotBronch_NO_COPD$PERSON_GENDER), 3) * 100
male.rm <- paste0("Male: ", male.ct.rm, "(", male.pct.rm, "%)")

gender.pvalue <- signif(chisq.test(table(lab, gstatus))$p.value, 3)

demo.table <- rbind(demo.table, c(male, male.rm, gender.pvalue))

# FEV1 predicted
mean.fev1p <- mean(annotBronch_COPD$FEV_RS_PER)
sd.fev1p <- sd(annotBronch_COPD$FEV_RS_PER)

fev1p <- paste0(signif(mean.fev1p, 3), " +/- ", signif(sd.fev1p, 3))

mean.fev1p.rm <- mean(annotBronch_NO_COPD$FEV_RS_PER)
sd.fev1p.rm <- sd(annotBronch_NO_COPD$FEV_RS_PER)

fev1p.rm <- paste0(signif(mean.fev1p.rm, 3), " +/- ", signif(sd.fev1p.rm, 3))

fev1p.pvalue <- signif(wilcox.test(annotBronch_COPD$FEV_RS_PER, annotBronch_NO_COPD$FEV_RS_PER)$p.value, 3)

demo.table <- rbind(demo.table, c(fev1p, fev1p.rm, fev1p.pvalue))

# FEVFVC
mean.fevfvc <- mean(annotBronch_COPD$FEV_FVC)
sd.fevfvc <- sd(annotBronch_COPD$FEV_FVC)

fevfvc <- paste0(signif(mean.fevfvc, 3), " +/- ", signif(sd.fevfvc, 3))

mean.fevfvc.rm <- mean(annotBronch_NO_COPD$FEV_FVC)
sd.fevfvc.rm <- sd(annotBronch_NO_COPD$FEV_FVC)

fevfvc.rm <- paste0(signif(mean.fevfvc.rm, 3), " +/- ", signif(sd.fevfvc.rm, 3))

fevfvc.pvalue <- signif(wilcox.test(annotBronch_COPD$FEV_FVC, annotBronch_NO_COPD$FEV_FVC)$p.value, 3)

demo.table <- rbind(demo.table, c(fevfvc, fevfvc.rm, fevfvc.pvalue))

# TIN
mean.tin <- mean(annotBronch_COPD$TIN)
sd.tin <- sd(annotBronch_COPD$TIN)

tin <- paste0(signif(mean.tin, 3), " +/- ", signif(sd.tin, 3))

mean.tin.rm <- mean(annotBronch_NO_COPD$TIN)
sd.tin.rm <- sd(annotBronch_NO_COPD$TIN)

tin.rm <- paste0(signif(mean.tin.rm, 3), " +/- ", signif(sd.tin.rm, 3))

tin.pvalue <- signif(wilcox.test(annotBronch_COPD$TIN, annotBronch_NO_COPD$TIN)$p.value, 3)

demo.table <- rbind(demo.table, c(tin, tin.rm, tin.pvalue))

# Smoking Status
smk <- c(annotBronch_COPD$GRPB_SMK_STS, annotBronch_NO_COPD$GRPB_SMK_STS)

annotBronch_COPD$GRPB_SMK_STS <- gsub(" ", "_", annotBronch_COPD$GRPB_SMK_STS)
annotBronch_NO_COPD$GRPB_SMK_STS <- gsub(" ", "_", annotBronch_NO_COPD$GRPB_SMK_STS)

smkstatus.na <- sum(is.na(annotBronch_COPD$GRPB_SMK_STS == "Current_Smoker"))

smkstatus.ct <- sum(annotBronch_COPD[!is.na(annotBronch_COPD$GRPB_SMK_STS), ]$GRPB_SMK_STS == "Current_Smoker")
smkstatus.pct <- signif(smkstatus.ct / nrow(annotBronch_COPD[!is.na(annotBronch_COPD$GRPB_SMK_STS), ]), 3) * 100
smkstatus <- paste0("Current: ", smkstatus.ct, "(", smkstatus.pct, "%)")

smkstatus.ct.rm <- sum(annotBronch_NO_COPD$GRPB_SMK_STS == "Current_Smoker")
smkstatus.pct.rm <- signif(smkstatus.ct.rm / length(annotBronch_NO_COPD$GRPB_SMK_STS), 3) * 100
smkstatus.rm <- paste0("Current: ", smkstatus.ct.rm, "(", smkstatus.pct.rm, "%)")

smkstatus.pvalue <- signif(chisq.test(table(lab, smk))$p.value, 3)

demo.table <- rbind(demo.table, c(smkstatus, smkstatus.rm, smkstatus.pvalue))

rownames(demo.table) <- c("Age", "Gender", "FEV1 Predicted(%)" , "FEV1/FVC", "TIN", "Smoking Status")
colnames(demo.table) <- c("COPD", "NO COPD", "p-value")

copd.race.table <- as.data.frame(table(annotBronch_COPD$RACE_CAT_TXT))
rownames(copd.race.table) <- copd.race.table$Var1
copd.race.table$Var1 <- NULL

nocopd.race.table <- as.data.frame(table(annotBronch_NO_COPD$RACE_CAT_TXT))
rownames(nocopd.race.table) <- nocopd.race.table$Var1
nocopd.race.table$Var1 <- NULL

race.table <- cbind(copd.race.table, nocopd.race.table)
race.table <- race.table[c(6, 2, 1, 5, 3, 4),]
colnames(race.table) <- c("COPD", "NO COPD")
race.table$`p-value` <- c(signif(chisq.test(race.table)$p.value, 3),
                        rep("", nrow(race.table) - 1))

blank <- as.data.frame(matrix("", ncol = 3))
colnames(blank) <- c("COPD", "NO COPD", "p-value")
rownames(blank) <- "Race"

race.table <- rbind(blank,race.table)

demo.table <- rbind(demo.table, race.table)

demo.table %>%
  knitr::kable(
    format = "html", align = rep("c", ncol(demo.table) + 1),
    row.names = TRUE
  ) %>%
  add_indent(c(8:13)) %>%
  kableExtra::kable_styling()
COPD NO COPD p-value
Age 63.4 +/- 5.72 63.3 +/- 6.6 0.804
Gender Male: 71(78%) Male: 67(83.8%) 0.452
FEV1 Predicted(%) 60.5 +/- 12.4 86.5 +/- 13.5 1.37e-22
FEV1/FVC 0.563 +/- 0.1 0.717 +/- 0.067 2.04e-21
TIN 70.5 +/- 1.23 70.4 +/- 1.44 0.903
Smoking Status Current: 34(37.4%) Current: 28(35%) 0.872
Race
White 69 61 0.518
Black or African American 17 11
Asian 2 2
Pacific Islander 2 1
Native American 0 1
Not Reported 1 4

Differential Expression

Using COPD as continuous variable

Differential expression was conducted using the DESeq2 package to compare patients with low FEV1pred values (< 80) and high values. The FEV1 predicted values are used as a proxy for COPD status. Expected counts outputted from the RSEM algorithm was taken for DESeq2.

Model used: ~Smoking status + Age + TIN + FEV1 predicted

dds <- DESeqDataSetFromMatrix(
  countData = counts,
  colData = annotBronch,
  design = ~GRPB_SMK_STS + AGE + TIN + FEV_RS_PER
)

dds$GRPB_SMK_STS <- relevel(dds$GRPB_SMK_STS, ref = "Former_Smoker")

keep <- rowSums(counts(dds)) >= 10
dds <- dds[keep, ]
dds <- DESeq(dds)
res <- results(dds)

res$nLogPVal <- -log10(res$padj)

resOrdered <- res[order(res$pvalue), ]
resOrdered <- as.data.frame(resOrdered)

#For pre-ranked GSEA
resOrderLFC <- res[order(res$log2FoldChange), ]
resOrderLFC <- resOrderLFC[,2, drop = F]
resOrderLFC$Gene <- rownames(resOrderLFC)
resOrderLFC <- resOrderLFC[,c(2,1)]
#write.table(resOrderLFC, "20201104_GSEA_Rankedlist_FEVPred_Bronch.rnk", sep = "\t", col.names = T, row.names = F)

resSig <- resOrdered[resOrdered$padj < 0.05,]
resSig <- resSig[!is.na(resSig$padj),]

resSig <- resSig[order(resSig$log2FoldChange), ]
numSig <- nrow(resSig)

resSigUp <- resSig[head(order(resSig$log2FoldChange, decreasing = T), 50),]
resSigDown <- resSig[head(order(resSig$log2FoldChange, decreasing = F), 50),]
resSig2 <- rbind(resSigDown, resSigUp)
# numUp <- nrow(resSig[resSig$log2FoldChange > 0.5, ])
# numDown <- nrow(resSig[resSig$log2FoldChange < -0.5, ])

resSig3 <- resSig[abs(resSig$log2FoldChange) > 0.01,]

A total of 1234 genes were passed the adjusted p-value < 0.05 threshold.

Volcano plot

g <- ggplot(resOrdered, aes(x = log2FoldChange, y = nLogPVal)) +
  geom_point(size = 0.75) +
  ggplot2::theme_bw() +
  ggplot2::theme(
    panel.grid.major = ggplot2::element_blank(),
    panel.grid.minor = ggplot2::element_blank(),
    axis.text = ggplot2::element_text(size = 14),
    axis.title = ggplot2::element_text(size = 14)
  ) +
  ggplot2::theme(legend.title = ggplot2::element_text(size = 15), legend.text = ggplot2::element_text(size = 13)) +
  ggplot2::guides(
    colour =
      ggplot2::guide_legend(override.aes = list(size = 2))
  )
if(nrow(resSig2) > 0){
g <- g +
  geom_point(data = resSig2, aes(x = log2FoldChange, y = nLogPVal), color = "Red")+
  ggplot2::labs(y = "-log10(Adjusted p-value)") +
  ggplot2::ggtitle(label = "COPD status") +
  ggplot2::theme(plot.title = ggplot2::element_text(
    hjust = 0.5,
    size = 18
  )) + geom_line(y = 1.3)
}

g

The red dots show the top 50 most up/down regulated genes which pass the adjusted p-value threshold.

Heatmap

All genes, FDR < 0.05

counts.z <- t(scale(t(counts)))
counts.z.trim <- counts.z

counts.z.trim[counts.z.trim < -2] <- -2
counts.z.trim[counts.z.trim > 2] <- 2

counts.z.trim <- counts.z.trim[rownames(counts.z.trim) %in% rownames(resSig),]

COPD_status <- annotBronch$COPD_status
Smoker_status <- annotBronch$GRPB_SMK_STS

annotation_col <- data.frame(COPD_status, Smoker_status)
rownames(annotation_col) <- colnames(counts.z.trim)
callback <- function(hc, mat) {
  sv <- svd(t(mat))$v[, 1]
  dend <- reorder(as.dendrogram(hc), wts = sv)
  as.hclust(dend)
}

out <- pheatmap(counts.z.trim,
  color = colorRampPalette(rev(brewer.pal(n = 7, name = "RdYlBu")))(100),
  annotation_col = annotation_col,
  legend = T,
  show_rownames = F,
  show_colnames = F,
  fontsize_row = 9,
  cluster_rows = TRUE,
  cluster_cols = TRUE
)

out

FDR < 0.05, Log2 Fold change > 0.01

474 genes total:

counts.z <- t(scale(t(counts)))
counts.z.trim <- counts.z

counts.z.trim[counts.z.trim < -2] <- -2
counts.z.trim[counts.z.trim > 2] <- 2

counts.z.trim <- counts.z.trim[rownames(counts.z.trim) %in% rownames(resSig3),]

COPD_status <- annotBronch$COPD_status
Smoker_status <- annotBronch$GRPB_SMK_STS

annotation_col <- data.frame(COPD_status, Smoker_status)
rownames(annotation_col) <- colnames(counts.z.trim)
callback <- function(hc, mat) {
  sv <- svd(t(mat))$v[, 1]
  dend <- reorder(as.dendrogram(hc), wts = sv)
  as.hclust(dend)
}

out <- pheatmap(counts.z.trim,
  color = colorRampPalette(rev(brewer.pal(n = 7, name = "RdYlBu")))(100),
  annotation_col = annotation_col,
  legend = T,
  show_rownames = F,
  show_colnames = F,
  fontsize_row = 9,
  cluster_rows = TRUE,
  cluster_cols = TRUE
)

out

Top 50 up/downreg genes, FDR < 0.05

counts.z <- t(scale(t(counts)))
counts.z.trim <- counts.z

counts.z.trim[counts.z.trim < -2] <- -2
counts.z.trim[counts.z.trim > 2] <- 2

counts.z.trim <- counts.z.trim[rownames(counts.z.trim) %in% rownames(resSig2),]

COPD_status <- annotBronch$COPD_status
Smoker_status <- annotBronch$GRPB_SMK_STS

annotation_col <- data.frame(COPD_status, Smoker_status)
rownames(annotation_col) <- colnames(counts.z.trim)
callback <- function(hc, mat) {
  sv <- svd(t(mat))$v[, 1]
  dend <- reorder(as.dendrogram(hc), wts = sv)
  as.hclust(dend)
}

out <- pheatmap(counts.z.trim,
  color = colorRampPalette(rev(brewer.pal(n = 7, name = "RdYlBu")))(100),
  annotation_col = annotation_col,
  legend = T,
  show_rownames = F,
  show_colnames = F,
  fontsize_row = 9,
  cluster_rows = TRUE,
  cluster_cols = TRUE
)

out

Tables

Top 50 most upregulated in higher FEV1 predicted, passing adjusted p-val threshold

resSigUp <- resSig[head(order(resSig$log2FoldChange, decreasing = T), 50),]
resSigUp <- resSigUp[,c(2,5,6)]
colnames(resSigUp) <- c("Log2FC", "P-value", "Adj. P-value")
resSigUp %>%
  knitr::kable(
    format = "html", align = rep("c", ncol(resSig) + 1),
    row.names = TRUE
  ) %>%
  kableExtra::kable_styling() %>%
  kableExtra::scroll_box(height = "300px")
Log2FC P-value Adj. P-value
PRSS27 0.0379322 0.0000002 0.0002730
COL4A3 0.0365198 0.0000034 0.0016830
WSCD2 0.0289860 0.0005595 0.0230708
HOPX 0.0273427 0.0000001 0.0001944
ANXA9 0.0269131 0.0000076 0.0023858
TRBV20-1 0.0267765 0.0002577 0.0153139
GPM6A 0.0267225 0.0001038 0.0095784
KRT4 0.0253379 0.0000648 0.0074744
LGI3 0.0250411 0.0001393 0.0109865
SFTPD 0.0249287 0.0000008 0.0007153
VGLL1 0.0249255 0.0005055 0.0218765
SOGA3 0.0242900 0.0005414 0.0228082
LRCH2 0.0241826 0.0002670 0.0156622
LYPD2 0.0241066 0.0002184 0.0140391
RP11-493K19.3 0.0237056 0.0000286 0.0049170
CYP4F22 0.0234669 0.0017149 0.0410806
WNK4 0.0233429 0.0009922 0.0312846
GCOM1 0.0229288 0.0000214 0.0040991
KCNAB1 0.0226309 0.0018498 0.0423868
CCR6 0.0223424 0.0014622 0.0378144
COL11A2 0.0215869 0.0004802 0.0211319
SCUBE1 0.0214229 0.0000167 0.0035708
GPR25 0.0211229 0.0011971 0.0341430
RP1-214M20.2 0.0211051 0.0002003 0.0134020
GRIK1 0.0208795 0.0001860 0.0128619
KLRC3 0.0206905 0.0004250 0.0199691
CNFN 0.0206484 0.0002364 0.0146705
FRMPD4 0.0205462 0.0004602 0.0206864
MC4R 0.0202437 0.0017792 0.0417944
GABBR2 0.0201894 0.0001731 0.0121874
TGM3 0.0198160 0.0000482 0.0062098
TTN 0.0195382 0.0001459 0.0112596
ABCG2 0.0193495 0.0004597 0.0206864
TRGV9 0.0192770 0.0008214 0.0278741
LINC01140 0.0189824 0.0000563 0.0069139
RP1-302D9.3 0.0188891 0.0011866 0.0340451
NDRG4 0.0186677 0.0000000 0.0000894
DMRT1 0.0184242 0.0014015 0.0372039
CLCA4 0.0182427 0.0006618 0.0250146
PNMAL1 0.0182427 0.0000489 0.0062591
IL23R 0.0182318 0.0010009 0.0313901
ISLR 0.0179292 0.0000413 0.0057640
TRGC1 0.0177230 0.0002066 0.0136422
LYPD1 0.0176844 0.0001246 0.0103622
HTR2B 0.0176811 0.0001100 0.0097128
RP4-635E18.6 0.0176241 0.0001005 0.0095321
CTSW 0.0176167 0.0012864 0.0356947
JAM2 0.0174415 0.0026048 0.0499456
SVOP 0.0170479 0.0023990 0.0474275
EEF1A1P13 0.0169299 0.0000057 0.0019819

Top 50 most downregulated in higher FEV1 predicted, passing adjusted p-val threshold

resSigDown <- resSig[head(order(resSig$log2FoldChange, decreasing = F), 50),]
resSigDown <- resSigDown[,c(2,5,6)]
colnames(resSigDown) <- c("Log2FC", "P-value", "Adj. P-value")
resSigDown %>%
  knitr::kable(
    format = "html", align = rep("c", ncol(resSig) + 1),
    row.names = TRUE
  ) %>%
  kableExtra::kable_styling() %>%
  kableExtra::scroll_box(height = "300px")
Log2FC P-value Adj. P-value
BPIFB6 -0.0484129 0.0000008 0.0007153
Z82214.3 -0.0475271 0.0000042 0.0017656
APOB -0.0452260 0.0000000 0.0000520
MUC6 -0.0375644 0.0000454 0.0060877
SLC13A5 -0.0362348 0.0000002 0.0003003
BPIFB2 -0.0360447 0.0000040 0.0017584
GAPDHP24 -0.0357892 0.0000656 0.0074744
TPO -0.0346712 0.0000002 0.0002730
CDH15 -0.0340649 0.0000050 0.0019048
ARHGAP40 -0.0339831 0.0000001 0.0002175
ADAMTS2 -0.0331682 0.0002798 0.0160567
REG4 -0.0330795 0.0001281 0.0104900
CACNA1E -0.0317633 0.0000000 0.0000148
CREG2 -0.0313896 0.0005600 0.0230708
U3.80 -0.0312975 0.0001503 0.0113298
PIRT -0.0310768 0.0014278 0.0373721
RP11-481N16.1 -0.0307317 0.0005510 0.0229493
CYP17A1 -0.0307271 0.0002142 0.0138803
AKR1B15 -0.0307221 0.0018493 0.0423868
PTHLH -0.0304859 0.0000000 0.0000894
RP11-157E16.1 -0.0304788 0.0002690 0.0157058
RP11-16E12.2 -0.0300302 0.0000032 0.0016404
SEMA6B -0.0297027 0.0000248 0.0046511
IL19 -0.0293362 0.0000041 0.0017584
CHRM1 -0.0291805 0.0003002 0.0164826
ZDHHC4P1 -0.0289177 0.0000001 0.0001944
CCL2 -0.0284188 0.0016311 0.0402878
RP11-167N4.2 -0.0282905 0.0000959 0.0093885
SLC25A48 -0.0276517 0.0001416 0.0110567
ALOX15B -0.0271650 0.0006381 0.0246279
ANO7 -0.0265786 0.0000001 0.0002251
IL17REL -0.0265489 0.0000328 0.0050852
CUX2 -0.0260713 0.0000006 0.0006226
AL133373.1 -0.0259011 0.0000002 0.0003003
FBN2 -0.0256705 0.0000000 0.0000145
RP11-395B7.2 -0.0256592 0.0000197 0.0039108
CTD-2530H12.7 -0.0248494 0.0000021 0.0014090
STXBP5L -0.0245286 0.0008426 0.0282699
NTRK2 -0.0244881 0.0000192 0.0038664
LINC00632 -0.0235877 0.0000469 0.0061483
DUSP5P1 -0.0235702 0.0000309 0.0049938
SNTG2 -0.0235254 0.0000199 0.0039108
CCL24 -0.0235165 0.0016407 0.0403513
RP11-115D19.1 -0.0234537 0.0009154 0.0299849
ZNF467 -0.0233902 0.0000002 0.0003003
AZGP1 -0.0233431 0.0000005 0.0005460
RPS20P1 -0.0232315 0.0000031 0.0016404
BCAS2P2 -0.0231343 0.0000151 0.0034200
ASB11 -0.0228571 0.0005534 0.0229795
B3GNT6 -0.0228472 0.0008057 0.0276069



Using COPD as categorical variable

Differential expression was conducted using the DESeq2 package to compare patients with low FEV1pred values (< 80) and high values, where all samples with low FEV1pred is considered to be COPD. Expected counts outputted from the RSEM algorithm was taken for DESeq2.

Model used: ~Smoking status + Age + TIN + COPD status

dds <- DESeqDataSetFromMatrix(
  countData = counts,
  colData = annotBronch,
  design = ~GRPB_SMK_STS + AGE + TIN + COPD_status
)

dds$GRPB_SMK_STS <- relevel(dds$GRPB_SMK_STS, ref = "Former_Smoker")
dds$COPD_status <- relevel(dds$COPD_status, ref = "NO_COPD")

keep <- rowSums(counts(dds)) >= 10
dds <- dds[keep, ]
dds <- DESeq(dds)
res <- results(dds)

res$nLogPVal <- -log10(res$padj)

resOrdered <- res[order(res$pvalue), ]
resOrdered <- as.data.frame(resOrdered)

#For pre-ranked GSEA
resOrderLFC <- res[order(res$log2FoldChange, decreasing = FALSE), ]
resOrderLFC <- resOrderLFC[,2, drop = F]
resOrderLFC$SAMPLE <- rownames(resOrderLFC)
resOrderLFC <- resOrderLFC[,c(2,1)]

write.table(resOrderLFC, "20201104_GSEA_Rankedlist_COPDstatus_Bronch.rnk", sep = "\t", col.names = T, row.names = F)

resSig <- resOrdered %>%
  filter(padj < 0.05) %>%
  filter(abs(log2FoldChange) > 0.5)
numSig <- nrow(resSig)
numUp <- nrow(resSig[resSig$log2FoldChange > 0.5, ])
numDown <- nrow(resSig[resSig$log2FoldChange < -0.5, ])

A total of 619(419 Upregulated, 200 Downregulated) genes were differentially expressed (padj < 0.05, abs(log2FC) > 0.5).

Corresponding microarray analysis

# steilingMicroarray <- readRDS("/restricted/projectnb/camplab/home/ykoga07/DECAMP/Novartis/Data/STEILING_bronch.RDS")
# 
# arrayPheno <- Biobase::pData(steilingMicroarray)
# arrayPheno$fev1_fvc_ratio <- arrayPheno$fev1_fvc_ratio/100
# 
# design <- model.matrix(~smoking_status+age+copd, data = arrayPheno)
# # design <- model.matrix(~percent_fev1+fev1_fvc_ratio+smoking_status+age+copd, data = arrayPheno)
# # design <- model.matrix(~percent_fev1+fev1_fvc_ratio+smoking_status+age+copd, data = arrayPheno)
# 
# fit <- lmFit(steilingMicroarray, design)  # fit each probeset to model
# efit <- eBayes(fit)        # empirical Bayes adjustment
# de.res <- topTable(efit, coef=2, number = 100000)
# 
# de.res$GeneName <- gsub("_at","",rownames(de.res))
# de.res$nLogPVal <- -log(de.res$adj.P.Val)
# eset.ranklist <- de.res[,c(9,3)]
# eset.ranklist <- eset.ranklist[order(eset.ranklist$logFC, decreasing = FALSE),]
# eset.ranklist <- read.table("/restricted/projectnb/camplab/home/ykoga07/DECAMP/Novartis/Analysis/1stPass/100525_lam_copdcovars_tval.rnk", header = F)
# 
# mart <- useMart(biomart = "ensembl", dataset = "hsapiens_gene_ensembl")
# 
# BM <- getBM(filters= "hgnc_symbol", attributes= c("ensembl_gene_id","hgnc_symbol"),values=eset.ranklist$V1,mart= mart)
# 
# BM <- BM[BM$ensembl_gene_id %in% rownames(assay(seBronch)),]
# BM <- BM[!duplicated(BM$hgnc_symbol),]
# mergeBM <- merge(eset.ranklist, BM, by.x = "V1", by.y = "hgnc_symbol")
# mergeBM <- mergeBM[,c(3,2)]
# mergeBM <- mergeBM[order(mergeBM$V2, decreasing = F),]
# mergeBM <- mergeBM[!duplicated(mergeBM$ensembl_gene_id),]
# 
# resSig2 <- resSig[rownames(resSig) %in% mergeBM$ensembl_gene_id,]
# resSig2Up <- resSig2[resSig2$log2FoldChange>0.5,]
# resSig2Down <- resSig2[resSig2$log2FoldChange < -0.5,]
# write.table(x = rownames(resSig2Up), file = "/restricted/projectnb/camplab/home/ykoga07/DECAMP/Novartis/Analysis/1stPass/20201125_DECAMP_Bronch_geneList_Up.grp", col.names = F, row.names = F)
# write.table(x = rownames(resSig2Down), file = "/restricted/projectnb/camplab/home/ykoga07/DECAMP/Novartis/Analysis/1stPass/20201125_DECAMP_Bronch_geneList_Down.grp", col.names = F, row.names = F)
# write.table(mergeBM, "20201125_GSEA_Rankedlist_COPDstatus_Bronch_FromSteilingMicroarray.rnk", sep = "\t", col.names = F, row.names = F)

Volcano plot

ggplot(resOrdered, aes(x = log2FoldChange, y = nLogPVal)) +
  geom_point(size = 0.75) +
  ggplot2::theme_bw() +
  ggplot2::theme(
    panel.grid.major = ggplot2::element_blank(),
    panel.grid.minor = ggplot2::element_blank(),
    axis.text = ggplot2::element_text(size = 14),
    axis.title = ggplot2::element_text(size = 14)
  ) +
  ggplot2::theme(legend.title = ggplot2::element_text(size = 15), legend.text = ggplot2::element_text(size = 13)) +
  ggplot2::guides(
    colour =
      ggplot2::guide_legend(override.aes = list(size = 2))
  ) +
  geom_point(data = resSig, aes(x = log2FoldChange, y = nLogPVal), color = "Red")+
  ggplot2::labs(y = "-log10(Adjusted p-value)") +
  ggplot2::ggtitle(label = "COPD status") +
  ggplot2::theme(plot.title = ggplot2::element_text(
    hjust = 0.5,
    size = 18
  ))

Heatmap

counts.z <- t(scale(t(counts)))
counts.z.trim <- counts.z

counts.z.trim[counts.z.trim < -2] <- -2
counts.z.trim[counts.z.trim > 2] <- 2

counts.z.trim <- counts.z.trim[rownames(counts.z.trim) %in% rownames(resSig),]

COPD_status <- annotBronch$COPD_status
Smoker_status <- annotBronch$GRPB_SMK_STS

annotation_col <- data.frame(COPD_status, Smoker_status)
rownames(annotation_col) <- colnames(counts.z.trim)
callback <- function(hc, mat) {
  sv <- svd(t(mat))$v[, 1]
  dend <- reorder(as.dendrogram(hc), wts = sv)
  as.hclust(dend)
}

out <- pheatmap(counts.z.trim,
  color = colorRampPalette(rev(brewer.pal(n = 7, name = "RdYlBu")))(100),
  annotation_col = annotation_col,
  legend = T,
  show_rownames = F,
  show_colnames = F,
  fontsize_row = 9,
  cluster_rows = TRUE,
  cluster_cols = TRUE
)

out

Violin Plots

dots <- T
boxplot <- F
violin <- T

df <- data.frame(
  x = annotBronch$`Sample Type`,
  y = counts["CEACAM5",]
)

p <- ggplot2::ggplot(df) +
  ggplot2::aes_string(
    x = "x",
    y = "y"
  )
if (dots == TRUE) {
  p <- p + ggplot2::geom_jitter(
    color = "blue",
    width = 0.2,
    height = 0,
    size = 1,
    alpha = 1
  )
}
if (boxplot == TRUE) {
  p <- p + ggplot2::geom_boxplot(
    width = 0.5,
    alpha = 0
  )
}
if (violin == TRUE) {
  p <- p + ggplot2::geom_violin(
    trim = TRUE,
    scale = "width",
    size = 1,
    fill = "grey",
    alpha = 0.75
  )
}

p <- p + ggplot2::theme_bw() +
  ggplot2::theme(
    panel.grid.major = ggplot2::element_blank(),
    panel.grid.minor = ggplot2::element_blank(),
    axis.text = ggplot2::element_text(size = 14),
    axis.title = ggplot2::element_text(size = 10)
  ) + ggplot2::theme(axis.text.x = ggplot2::element_text(size = 15)) +
  ggplot2::ylab("Counts") +
  ggplot2::theme(
    axis.title.y = element_text(size = 15),
    axis.title.x = ggplot2::element_blank()
  )

p <- p + ggplot2::ggtitle(label = "Gene: CEACAM5") +
  ggplot2::theme(plot.title = ggplot2::element_text(
    hjust = 0.5,
    size = 18
  ))

p

Tables

Differentially expressed in COPD patients

resSigDown <- resSig[resSig$log2FoldChange < -0.5, ]
resSigDown <- resSigDown[order(resSigDown$log2FoldChange, decreasing = F),]
resSigDown <- resSigDown[,c(2,5,6)]
colnames(resSigDown) <- c("Log2FC", "P-value", "Adj. P-value")
resSigDown %>%
  knitr::kable(
    format = "html", align = rep("c", ncol(resSig) + 1),
    row.names = TRUE
  ) %>%
  kableExtra::kable_styling() %>%
  kableExtra::scroll_box(height = "300px")
Log2FC P-value Adj. P-value
HCG22 -2.3864692 0.0015128 0.0201796
SLURP1 -1.7935469 0.0003667 0.0086078
TRBV4-2 -1.7882811 0.0000122 0.0011873
IGHG4 -1.6651710 0.0014029 0.0193048
PRSS27 -1.6101254 0.0000000 0.0000010
OPN1SW -1.5957304 0.0010852 0.0166257
FENDRR -1.3582936 0.0005712 0.0111520
HOPX -1.2004463 0.0000000 0.0000003
ANXA9 -1.1863015 0.0000000 0.0000225
SOGA3 -1.1492763 0.0000050 0.0007196
RP11-64C1.1 -1.1236122 0.0002747 0.0073143
TRAV4 -1.1165131 0.0006128 0.0116053
DOK5 -1.0939985 0.0000523 0.0028516
TMEM145 -1.0712583 0.0002076 0.0062665
ZNF728 -1.0521973 0.0043615 0.0382570
KISS1 -1.0231259 0.0000045 0.0006861
CNFN -1.0093486 0.0000004 0.0001590
TRAV21 -1.0008325 0.0011965 0.0176970
TGM3 -0.9997551 0.0000000 0.0000090
ABCG2 -0.9948421 0.0000004 0.0001513
RP11-250H24.4 -0.9759165 0.0024518 0.0268393
DIRAS2 -0.9724012 0.0000026 0.0005001
WSCD2 -0.9716562 0.0015092 0.0201796
SLC4A10 -0.9445816 0.0003535 0.0084306
CYP4F22 -0.9350872 0.0005134 0.0105094
GABRD -0.9303349 0.0008577 0.0144304
PCOLCE2 -0.9291663 0.0030267 0.0304347
RP11-377G16.2 -0.9270751 0.0020774 0.0243381
GCOM1 -0.9066369 0.0000031 0.0005595
ALOX12 -0.8962265 0.0000466 0.0026593
RP1-214M20.2 -0.8847713 0.0000144 0.0012903
TM4SF19.1 -0.8822887 0.0060362 0.0462842
SFTPD -0.8781367 0.0000018 0.0003930
SPARCL1 -0.8767599 0.0000007 0.0002323
RP11-875H7.5 -0.8634227 0.0009141 0.0149692
GPM6A -0.8609836 0.0006162 0.0116407
TRGV4 -0.8596803 0.0017601 0.0219497
TRBV20-1 -0.8572522 0.0013399 0.0187906
FABP3 -0.8390524 0.0065172 0.0485614
LRCH2 -0.8287418 0.0005165 0.0105484
RP11-493K19.3 -0.8224368 0.0000654 0.0032312
LYPD1 -0.8221815 0.0000005 0.0001722
GRIK1 -0.8071296 0.0000590 0.0030600
OR51E2 -0.8057666 0.0007976 0.0136894
GRID1 -0.8056541 0.0000616 0.0031605
HHIP -0.7990500 0.0000452 0.0026455
C21orf88 -0.7950731 0.0017756 0.0220915
CTD-2626G11.2 -0.7946462 0.0000249 0.0017812
HLA-DQB2 -0.7889908 0.0002631 0.0071085
A2ML1 -0.7834005 0.0044364 0.0386373
CYS1 -0.7766507 0.0000205 0.0015617
ZNF835 -0.7660486 0.0003671 0.0086078
RP1-302D9.3 -0.7657790 0.0002659 0.0071756
RP11-215H22.1 -0.7632948 0.0002108 0.0062863
KIF12 -0.7590129 0.0006999 0.0125690
MC4R -0.7565352 0.0012489 0.0181279
CRTAM -0.7532744 0.0001553 0.0053904
ZNF385B -0.7483271 0.0022363 0.0253666
FLT4 -0.7464879 0.0052498 0.0425079
AC002456.2 -0.7454221 0.0008882 0.0147313
GPC3 -0.7431350 0.0000008 0.0002460
GABBR2 -0.7405785 0.0001379 0.0050188
TMPRSS11A -0.7390167 0.0051653 0.0422233
TBX4 -0.7351109 0.0006565 0.0120741
SCGB3A1 -0.7348552 0.0005690 0.0111492
SCGB1A1 -0.7342287 0.0056071 0.0442569
TMPRSS11E -0.7332024 0.0006886 0.0124607
CTXN3 -0.7328341 0.0041174 0.0368094
TMPRSS11F -0.7327097 0.0067088 0.0493200
RP11-73M7.6 -0.7302310 0.0025263 0.0272698
KCNJ1 -0.7226517 0.0008292 0.0140521
CAMK2N1 -0.7168096 0.0000114 0.0011414
CD52 -0.7147869 0.0009119 0.0149692
ISLR -0.7081926 0.0000080 0.0009471
NPPC -0.7066265 0.0000816 0.0036453
SLC6A13 -0.7023833 0.0002920 0.0076297
MFAP4 -0.6926880 0.0014551 0.0197597
SLC5A7 -0.6912281 0.0001584 0.0054604
C2orf72 -0.6864001 0.0037487 0.0347841
RPL32P1 -0.6757923 0.0021953 0.0250980
KRT4 -0.6741877 0.0040932 0.0367187
JAM2 -0.6728379 0.0012574 0.0182066
SCUBE1 -0.6722157 0.0002405 0.0068286
CTSW -0.6650400 0.0008849 0.0147150
STAC -0.6637347 0.0012836 0.0183927
AC068831.3 -0.6612633 0.0040383 0.0363660
BPI -0.6593759 0.0002061 0.0062665
DUSP26 -0.6587218 0.0002169 0.0063910
EMP1 -0.6578094 0.0007782 0.0135407
FEZF2 -0.6554235 0.0029164 0.0297500
C6orf229 -0.6545682 0.0061458 0.0467481
PLA2G1B -0.6545144 0.0028344 0.0292210
CLEC4F -0.6535467 0.0003011 0.0077735
ACOXL -0.6446535 0.0000925 0.0039035
KCNA3 -0.6443652 0.0002871 0.0075340
RP11-307C19.1 -0.6438555 0.0035422 0.0335697
ST6GAL2 -0.6418108 0.0000024 0.0004794
RP4-785G19.5 -0.6416908 0.0021960 0.0250980
CTC-260E6.6 -0.6414205 0.0013201 0.0186358
TRAC -0.6399490 0.0001824 0.0059236
P4HA3 -0.6391167 0.0001123 0.0044235
EEF1A1P13 -0.6388126 0.0000029 0.0005433
MEIOB -0.6382258 0.0046355 0.0396591
MYZAP -0.6282005 0.0022378 0.0253718
CLCA4 -0.6257042 0.0014691 0.0198866
ADAMTSL1 -0.6256839 0.0000280 0.0019072
GPR174 -0.6240299 0.0001287 0.0048256
JAKMIP2 -0.6153699 0.0004362 0.0095129
DLC1 -0.6152811 0.0024294 0.0267082
SMTNL2 -0.6109394 0.0022274 0.0253102
DMRT1 -0.6096933 0.0034794 0.0331327
CYP2W1 -0.6084916 0.0004378 0.0095225
SYT13 -0.6082086 0.0001410 0.0050749
GPR124 -0.6075574 0.0005623 0.0110796
RP11-284N8.3 -0.6071607 0.0007323 0.0129842
RP11-239E10.2 -0.6071463 0.0000102 0.0010914
SLC7A14 -0.6069894 0.0033177 0.0321168
BEX1 -0.6049220 0.0006089 0.0115753
TSPAN18 -0.6046893 0.0037386 0.0347536
CPB2-AS1 -0.5960951 0.0022490 0.0254654
CD207 -0.5914865 0.0007423 0.0130941
LEPR -0.5863591 0.0009848 0.0156428
KCNJ6 -0.5856257 0.0003463 0.0083552
FCRL6 -0.5850643 0.0061356 0.0467069
KCNK3 -0.5835709 0.0004749 0.0100396
CX3CR1 -0.5829135 0.0007260 0.0128821
FRRS1L -0.5827754 0.0047766 0.0403116
KRT17P2 -0.5813198 0.0041036 0.0367523
ADH1B -0.5805016 0.0000050 0.0007196
ITM2A -0.5803643 0.0001585 0.0054604
ZNF114 -0.5789884 0.0008611 0.0144786
CDH7 -0.5785158 0.0021593 0.0248669
RAMP2 -0.5784359 0.0000124 0.0011976
KIAA0408 -0.5783474 0.0008939 0.0147609
AC007347.1 -0.5748353 0.0001597 0.0054860
CCL5 -0.5740615 0.0016482 0.0212110
NPBWR1 -0.5722081 0.0042003 0.0372118
RP4-635E18.6 -0.5721799 0.0005734 0.0111693
PEG10 -0.5712589 0.0000176 0.0014563
CNGA1 -0.5691645 0.0002345 0.0067324
TRGC2 -0.5684042 0.0020908 0.0244379
DDC -0.5649902 0.0008754 0.0146235
SKAP1 -0.5636253 0.0000010 0.0002639
SEC14L3 -0.5633833 0.0046436 0.0396887
PPFIA2 -0.5622687 0.0005713 0.0111520
NDRG4 -0.5620810 0.0000066 0.0008342
QPRT -0.5580279 0.0000128 0.0012152
TSPAN7 -0.5579895 0.0002001 0.0061642
HLA-DOA -0.5576637 0.0043708 0.0382805
APOBEC3H -0.5544878 0.0002150 0.0063758
AC020571.3 -0.5543959 0.0048194 0.0405436
UBE2QL1 -0.5516127 0.0000493 0.0027462
MYOZ1 -0.5512993 0.0001388 0.0050445
RUNX1T1 -0.5498136 0.0001105 0.0043950
LINC01140 -0.5451518 0.0017522 0.0219488
IFIT1 -0.5442635 0.0000943 0.0039184
CSTF3-AS1 -0.5435079 0.0002272 0.0065993
PADI3 -0.5398219 0.0015904 0.0207453
LGR5 -0.5377769 0.0044125 0.0385223
CH25H -0.5372711 0.0000388 0.0024265
AP001347.6 -0.5361103 0.0002610 0.0070739
OASL -0.5355939 0.0056885 0.0447076
SNCG -0.5345337 0.0001499 0.0052986
CTD-2135D7.2 -0.5325317 0.0049373 0.0411311
ROBO2 -0.5306888 0.0000302 0.0020068
ADH1C -0.5276992 0.0000063 0.0008142
RP11-389K14.3 -0.5272550 0.0019921 0.0237275
SCG5 -0.5272260 0.0023872 0.0264362
EMID1 -0.5267117 0.0001908 0.0060443
CYP2F1 -0.5218862 0.0000223 0.0016607
LINC00996 -0.5195705 0.0015679 0.0205904
APOBEC2 -0.5192123 0.0049521 0.0412149
KCNA4 -0.5187887 0.0012753 0.0183303
RP11-568A7.2 -0.5180328 0.0004542 0.0097729
RP4-564M11.2 -0.5179555 0.0024962 0.0270719
AC027601.1 -0.5166162 0.0029202 0.0297500
AC226118.1 -0.5162691 0.0004802 0.0101065
AC005082.12 -0.5158740 0.0009718 0.0155756
HLF -0.5155131 0.0000016 0.0003844
NAP1L3 -0.5151662 0.0001883 0.0060014
LRP1B -0.5137005 0.0009156 0.0149731
SLC38A4 -0.5134971 0.0003171 0.0080114
UBASH3A -0.5124762 0.0007353 0.0130195
FBN1 -0.5118322 0.0000458 0.0026455
CPED1 -0.5102563 0.0014392 0.0196211
CYP2A13 -0.5098383 0.0020638 0.0242722
FAM89A -0.5095007 0.0051090 0.0419715
GJA1 -0.5094236 0.0000179 0.0014607
FGF18 -0.5087330 0.0043583 0.0382518
PROS1 -0.5079921 0.0010033 0.0157922
TRBC2 -0.5054618 0.0022070 0.0251986
DCX -0.5051410 0.0044268 0.0385848
SMOC2 -0.5050210 0.0000904 0.0038788
FGF9 -0.5049568 0.0000228 0.0016888
CNKSR2 -0.5044825 0.0000795 0.0036006
VSTM4 -0.5034349 0.0003624 0.0085426
KLRK1 -0.5032737 0.0017614 0.0219497
ECM2 -0.5032527 0.0000352 0.0022391
CD8B -0.5011585 0.0038495 0.0353345
KIAA1462 -0.5010617 0.0020661 0.0242722
# write.table(resSigDown, "20201112_Up_in_COPD_Bronch.txt", sep = "\t", quote=F)

Differentially expressed in non-COPD patients

resSigUp <- resSig[resSig$log2FoldChange > 0.5, ]
resSigUp <- resSigUp[order(resSigUp$log2FoldChange, decreasing = T),]
resSigUp <- resSigUp[,c(2,5,6)]
colnames(resSigUp) <- c("Log2FC", "P-value", "Adj. P-value")
resSigUp %>%
  knitr::kable(
    format = "html", align = rep("c", ncol(resSig) + 1),
    row.names = TRUE
  ) %>%
  kableExtra::kable_styling() %>%
  kableExtra::scroll_box(height = "300px")
Log2FC P-value Adj. P-value
STC1 2.2802176 0.0000000 0.0000010
SLC6A10P 2.1910697 0.0002990 0.0077433
Z82214.3 1.8690658 0.0000007 0.0002348
BPIFB6 1.8233056 0.0000004 0.0001674
CTD-3118D7.1 1.7859920 0.0000187 0.0014889
MUC3A 1.7289481 0.0000056 0.0007643
APOB 1.6658811 0.0000000 0.0000118
PAX6 1.6033870 0.0004596 0.0098152
MUC6 1.5711397 0.0000025 0.0004803
TPO 1.5209755 0.0000000 0.0000006
DPCR1 1.4355268 0.0003097 0.0079349
ARHGAP40 1.4010723 0.0000000 0.0000020
PCDH15 1.3451918 0.0024073 0.0265214
BPIFB2 1.3307664 0.0000035 0.0005948
IL17REL 1.3159170 0.0000000 0.0000094
CACNA1E 1.3158698 0.0000000 0.0000000
GRM7-AS1 1.3097725 0.0007791 0.0135428
RP11-167N4.2 1.3036335 0.0000007 0.0002298
SLC13A5 1.3022798 0.0000004 0.0001513
ALOX15B 1.2553555 0.0000121 0.0011855
REG4 1.2536849 0.0000646 0.0032187
CREG2 1.2522371 0.0001457 0.0051982
EDN2 1.2235233 0.0028463 0.0292864
C8orf22 1.2221970 0.0027706 0.0288886
SNTG2 1.2159686 0.0000000 0.0000011
BMP8A 1.2121615 0.0003433 0.0083281
RP11-139K4.2 1.2103870 0.0000380 0.0023818
CSF3 1.2078871 0.0001984 0.0061280
RP11-138A9.2 1.2018027 0.0004080 0.0092355
RP11-157E16.1 1.1889221 0.0000788 0.0035892
ANO7 1.1720775 0.0000000 0.0000003
PIRT 1.1661742 0.0009810 0.0156338
CHRM1 1.1586391 0.0000700 0.0033416
RP11-481N16.1 1.1430760 0.0004337 0.0094744
SLC25A48 1.1391164 0.0000179 0.0014607
RP11-567M16.2 1.1180493 0.0003396 0.0082711
AL133373.1 1.1147990 0.0000000 0.0000011
C1orf95 1.1137259 0.0000011 0.0002981
FAM189A1 1.1130344 0.0059601 0.0459847
HKDC1 1.1095670 0.0000003 0.0001342
GAPDHP24 1.1079986 0.0007809 0.0135542
PXDN 1.1079226 0.0000000 0.0000010
ZDHHC4P1 1.1075640 0.0000000 0.0000147
CDH15 1.1048649 0.0000497 0.0027612
PTHLH 1.0995579 0.0000000 0.0000261
RP11-89K21.1 1.0968992 0.0012437 0.0180929
LIPG 1.0812755 0.0000066 0.0008342
NTRK2 1.0642048 0.0000002 0.0000909
SIX3 1.0582863 0.0000797 0.0036006
RP11-779P15.2 1.0565586 0.0014002 0.0192783
PMS2P10 1.0392064 0.0028860 0.0295173
IL19 1.0178270 0.0000120 0.0011728
RP11-439L8.3 1.0156225 0.0000199 0.0015513
AC012501.2 1.0101285 0.0036346 0.0341523
B3GNT6 1.0066858 0.0000423 0.0025675
RP11-139K4.4 1.0000498 0.0000007 0.0002298
RP11-333O1.1 0.9979751 0.0049601 0.0412358
AQP7P1 0.9953444 0.0004687 0.0099612
SLCO1B7 0.9935182 0.0018572 0.0226495
AL354898.1 0.9930726 0.0043948 0.0384051
RP11-687D19.1 0.9878544 0.0007001 0.0125690
LEFTY1 0.9865289 0.0011539 0.0173171
STXBP5L 0.9817248 0.0002391 0.0068094
MICD 0.9804493 0.0000369 0.0023211
RP11-507B12.1 0.9629970 0.0021586 0.0248669
FLNC 0.9619265 0.0000049 0.0007152
CGREF1 0.9614465 0.0002335 0.0067105
GOLGA6B 0.9595250 0.0005255 0.0106222
SLCO1B3 0.9548557 0.0000436 0.0025946
DUSP5P1 0.9477895 0.0000039 0.0006309
GOLGA7B.1 0.9423668 0.0029528 0.0299979
RP11-16E12.2 0.9416867 0.0001018 0.0041658
FEZF1 0.9287649 0.0063670 0.0479009
FKBP5 0.9227220 0.0000001 0.0000508
NPM1P43 0.9211773 0.0005307 0.0106798
RP11-460N11.3 0.9182599 0.0015595 0.0205364
ZNF467 0.9166568 0.0000000 0.0000168
RP11-395B7.2 0.9164471 0.0000334 0.0021484
CTD-2509G16.3 0.9162443 0.0004330 0.0094744
U3.80 0.9097359 0.0030444 0.0305769
RP11-115D19.1 0.9084628 0.0004273 0.0093990
SSPO 0.9080064 0.0000000 0.0000132
RP11-439L8.4 0.9058979 0.0000470 0.0026637
RP11-139K4.1 0.8914952 0.0000001 0.0000379
CDSN 0.8871000 0.0026822 0.0282420
CYP17A1 0.8842914 0.0037402 0.0347536
EPS8L3 0.8830837 0.0009908 0.0156741
SLC6A1 0.8814102 0.0050176 0.0415311
AC015987.2 0.8711021 0.0004431 0.0095905
FBN2 0.8683692 0.0000000 0.0000168
LINC00342 0.8683322 0.0000044 0.0006793
RP1-37C10.3 0.8666098 0.0023047 0.0258569
RPL21P112 0.8656450 0.0022159 0.0252246
FAM177B 0.8630706 0.0000044 0.0006793
RP11-838N2.8 0.8565901 0.0006507 0.0120028
IDI2-AS1 0.8553067 0.0010945 0.0167282
COMP 0.8533607 0.0020652 0.0242722
C1QTNF1 0.8525928 0.0009821 0.0156338
AZGP1 0.8478495 0.0000006 0.0002136
RP11-803D5.4 0.8453177 0.0000236 0.0017277
EEF1DP5 0.8400569 0.0006702 0.0122548
AHSG 0.8369773 0.0048318 0.0406150
AC098592.7 0.8330522 0.0001233 0.0047183
RP5-914M6.1 0.8324801 0.0004806 0.0101065
YAP1P1 0.8279149 0.0032406 0.0317538
MTND4P12 0.8259292 0.0002818 0.0074391
CTB-102L5.8 0.8249917 0.0032962 0.0319930
ITGA10 0.8216204 0.0000006 0.0001949
FIGN 0.8176383 0.0000005 0.0001701
RP11-10H3.1 0.8162534 0.0031539 0.0312348
LRRC31 0.8142625 0.0000077 0.0009200
RP11-386M24.5 0.8137338 0.0034447 0.0328752
AC144450.2 0.8112034 0.0000000 0.0000071
RP11-527N22.1 0.8083172 0.0011072 0.0168221
FAM157B 0.8075813 0.0024752 0.0269577
CUX2 0.8075334 0.0000302 0.0020068
RP11-194N12.2 0.8062291 0.0013692 0.0190958
RN7SKP151 0.8049246 0.0001865 0.0059830
WNT16 0.7989340 0.0007900 0.0135948
RP11-80I15.1 0.7961854 0.0000128 0.0012152
ASNSP3 0.7943701 0.0000018 0.0003930
SEMA6B 0.7933276 0.0023853 0.0264362
TDGF1P4 0.7871098 0.0050168 0.0415311
BCAS2P2 0.7851954 0.0000628 0.0031821
SLC17A9 0.7810516 0.0000018 0.0003930
RPLP0P2 0.7810449 0.0004219 0.0093284
ENTPD2 0.7809707 0.0000000 0.0000020
WDR72 0.7799025 0.0000022 0.0004537
GOLGA6L10 0.7788106 0.0032463 0.0317728
RNU5E-6P 0.7765796 0.0005455 0.0108481
RP11-508M8.1 0.7727333 0.0050119 0.0415311
AQP7P3 0.7713275 0.0001727 0.0057324
RP11-893F2.9 0.7663894 0.0005455 0.0108481
GOLGA7B 0.7663690 0.0001983 0.0061280
U3.7 0.7658721 0.0024289 0.0267082
MUC5AC 0.7652430 0.0001773 0.0058281
GPR153 0.7650752 0.0000055 0.0007643
LDLRAD2 0.7645421 0.0000000 0.0000168
DAAM2 0.7630483 0.0000828 0.0036453
AC124944.4 0.7617858 0.0056907 0.0447113
LINC00632 0.7602183 0.0004096 0.0092459
LA16c-425C2.1 0.7582489 0.0000827 0.0036453
CTD-2530H12.7 0.7573317 0.0001009 0.0041363
CTD-2267D19.6 0.7553498 0.0001489 0.0052847
CTD-3193O13.1 0.7541919 0.0000709 0.0033736
CCL24 0.7527081 0.0061780 0.0468771
F5 0.7490325 0.0000011 0.0002858
RP11-2E11.5 0.7475000 0.0058795 0.0455949
RN7SL105P 0.7472610 0.0004983 0.0103240
AZGP1P1 0.7417958 0.0044137 0.0385223
RP4-713A8.1 0.7396379 0.0008328 0.0140956
C2CD4A 0.7374139 0.0000440 0.0026061
AC073218.2 0.7307830 0.0011322 0.0171098
PTGS2 0.7289908 0.0001296 0.0048450
RP11-5L12.1 0.7274469 0.0048803 0.0408152
DOC2B 0.7263661 0.0006268 0.0117429
AC020907.1 0.7245049 0.0007369 0.0130391
ZBTB16 0.7241821 0.0009144 0.0149692
AC138035.1 0.7223241 0.0015351 0.0203407
DHRSX-IT1 0.7172868 0.0001475 0.0052562
PHACTR3 0.7168333 0.0027491 0.0287316
NANOGP7 0.7152823 0.0000585 0.0030453
ELMOD1 0.7129683 0.0000658 0.0032312
SERHL2 0.7126315 0.0000061 0.0007998
RP11-589C21.6 0.7122100 0.0001930 0.0060647
BRINP1 0.7089327 0.0044142 0.0385223
AC006003.3 0.7085877 0.0011863 0.0176073
RP11-259O2.1 0.7085502 0.0014797 0.0199352
NEAT1 0.7069154 0.0000003 0.0001512
KCNN2 0.7055893 0.0035739 0.0337575
RPS20P1 0.7052842 0.0001361 0.0049878
CYP3A5 0.7025365 0.0002024 0.0062135
CPNE4 0.6971037 0.0001367 0.0049968
RP13-726E6.3 0.6968872 0.0036570 0.0342778
RN7SL739P 0.6968854 0.0013355 0.0187499
PTPRH 0.6967019 0.0002416 0.0068441
DNAJC12 0.6965788 0.0000185 0.0014859
RP11-386M24.6 0.6947778 0.0003637 0.0085553
AC108066.1 0.6927396 0.0046537 0.0397125
TNNI3 0.6895294 0.0000024 0.0004780
REP15 0.6863976 0.0000160 0.0013776
RP11-430B1.1 0.6826777 0.0020739 0.0243187
AP000695.6 0.6807910 0.0022200 0.0252484
Metazoa_SRP.12 0.6768366 0.0002958 0.0076932
ADRA2A 0.6753578 0.0001356 0.0049763
TMC7 0.6732001 0.0000001 0.0000729
ENTPD8 0.6707694 0.0000173 0.0014488
RP11-221J22.2 0.6689997 0.0005659 0.0111150
FDPSP3 0.6672645 0.0000805 0.0036201
AF131215.6 0.6663677 0.0030051 0.0303008
TFF1 0.6656251 0.0025258 0.0272698
CTD-2589M5.4 0.6655705 0.0002820 0.0074391
RP11-10J21.4 0.6623944 0.0064718 0.0483631
RP11-480G7.1 0.6612726 0.0000525 0.0028516
RP4-609E1.2 0.6612028 0.0018409 0.0225540
CTC-548K16.6 0.6606675 0.0000891 0.0038393
RN7SL57P 0.6600234 0.0000669 0.0032721
RP11-77H9.5 0.6588525 0.0001544 0.0053875
FAM157C 0.6576799 0.0000098 0.0010757
RP3-363L9.1 0.6566384 0.0007351 0.0130195
RP11-47G11.2 0.6554680 0.0003918 0.0089710
RP11-74C1.2 0.6540906 0.0000186 0.0014882
JAKMIP3 0.6540259 0.0012947 0.0184917
RP11-120K24.4 0.6534771 0.0000032 0.0005713
RP11-435B5.5 0.6517619 0.0020961 0.0244481
CTD-2047H16.2 0.6473474 0.0002744 0.0073122
CEACAM5 0.6468732 0.0031817 0.0313801
AP000889.3 0.6445893 0.0048654 0.0407301
SPDEF 0.6439825 0.0000319 0.0020723
RP5-981O7.2 0.6436388 0.0000003 0.0001390
AC078852.2 0.6426335 0.0022135 0.0252246
MUC1 0.6426249 0.0000000 0.0000043
AC007036.4 0.6424753 0.0000354 0.0022431
RP11-18F14.4 0.6418176 0.0011714 0.0174781
SLC26A2 0.6402932 0.0000001 0.0000508
THBS1 0.6378750 0.0000419 0.0025579
CATSPERB 0.6363337 0.0000000 0.0000135
SULT1C2 0.6336007 0.0010821 0.0166011
CTB-193M12.3 0.6329112 0.0002520 0.0069591
RP11-496D24.2 0.6324266 0.0028561 0.0293635
AC092168.2 0.6323481 0.0001051 0.0042738
RP11-297K8.2 0.6299306 0.0009634 0.0154737
PNCK 0.6294998 0.0004467 0.0096363
RP11-1191J2.2 0.6282962 0.0029801 0.0301316
AC008132.13 0.6267860 0.0008807 0.0146735
AC112518.3 0.6239440 0.0000113 0.0011414
RN7SKP95 0.6213521 0.0013808 0.0191326
RP11-864J10.2 0.6212002 0.0016983 0.0214305
GS1-122H1.3 0.6194692 0.0028910 0.0295551
CHCHD4P2 0.6188037 0.0003137 0.0079707
KCP 0.6187811 0.0024825 0.0270084
ADM2 0.6179245 0.0000016 0.0003661
VN1R51P 0.6168663 0.0005712 0.0111520
SLC25A18 0.6168032 0.0036173 0.0340919
RN7SKP24 0.6162040 0.0000692 0.0033167
RP11-447H19.3 0.6160178 0.0045266 0.0390912
UNC5A 0.6151160 0.0059948 0.0461162
CTC-244M17.1 0.6149821 0.0000424 0.0025675
SERPINB4 0.6147896 0.0006177 0.0116526
NID2 0.6133132 0.0052442 0.0425079
CTD-2589H19.6 0.6127672 0.0026819 0.0282420
ADORA3 0.6125718 0.0004376 0.0095225
TMEM211 0.6123906 0.0000039 0.0006283
RP11-168F9.2 0.6078583 0.0044876 0.0389508
PRSS16 0.6077625 0.0000000 0.0000236
AL627309.1 0.6074216 0.0011047 0.0168054
NARF-IT1 0.6071972 0.0000040 0.0006422
RP11-1036E20.9 0.6062101 0.0000001 0.0000502
RP11-380J14.1 0.6057669 0.0000212 0.0016032
RP11-458F8.2 0.6055018 0.0033041 0.0320429
RP11-324E6.6 0.6049054 0.0053533 0.0429934
RPS4XP22 0.6033927 0.0007829 0.0135542
RP11-797A18.4 0.6032046 0.0000004 0.0001627
AC016559.1 0.6028178 0.0015340 0.0203407
IRAK3 0.6021432 0.0000000 0.0000251
SHROOM1 0.6003467 0.0000014 0.0003441
RP11-3K24.1 0.5998078 0.0013500 0.0189014
TCN1 0.5989780 0.0019457 0.0233376
MYLK3 0.5987669 0.0001154 0.0045048
RP11-164H5.1 0.5984192 0.0003574 0.0084713
RP11-49O14.3 0.5980525 0.0000104 0.0011029
HK2P1 0.5974026 0.0040816 0.0366273
AC138517.1 0.5959937 0.0040339 0.0363522
RP11-112L18.1 0.5952027 0.0020410 0.0241032
ATP5A1P3 0.5946478 0.0000096 0.0010602
ANKRD36C 0.5933542 0.0004807 0.0101065
CTD-2547H18.1 0.5928804 0.0010601 0.0163950
PLEKHD1 0.5911511 0.0003312 0.0081736
RP11-359B20.1 0.5908479 0.0001330 0.0049102
RPL7L1P2 0.5905607 0.0000305 0.0020171
PYCR1 0.5900049 0.0000047 0.0007035
LBX2 0.5895572 0.0003346 0.0082269
AC005077.14 0.5888899 0.0000005 0.0001878
RP11-131K5.1 0.5877011 0.0012684 0.0182802
DQX1 0.5870439 0.0000000 0.0000168
CTB-11I22.2 0.5844118 0.0004153 0.0092943
AC110619.1 0.5820199 0.0002023 0.0062135
LAP3P1 0.5799572 0.0000106 0.0011099
AC144450.1 0.5798538 0.0010304 0.0160632
GS1-122H1.1 0.5794545 0.0032951 0.0319930
RN7SKP239 0.5790295 0.0003293 0.0081676
ADAMDEC1 0.5787993 0.0028423 0.0292803
RP11-195B21.3 0.5758041 0.0010020 0.0157841
RP11-27M24.2 0.5755681 0.0056420 0.0444645
AP001468.1 0.5747175 0.0065673 0.0488126
CXCL2 0.5733062 0.0053491 0.0429866
CCDC144NL 0.5717484 0.0055756 0.0441309
RP11-100J16.4 0.5713423 0.0028455 0.0292864
RP11-381G8.1 0.5713423 0.0028455 0.0292864
AC097468.4 0.5709202 0.0011236 0.0170010
PRKXP1 0.5706856 0.0039136 0.0356553
CTHRC1 0.5698637 0.0065886 0.0488952
RP11-486O13.4 0.5694970 0.0027173 0.0284954
RP11-353J17.3 0.5691443 0.0002440 0.0068717
ITPKB-IT1 0.5680758 0.0023671 0.0262924
RP11-332H18.3 0.5664058 0.0003317 0.0081736
RP5-1041C10.3 0.5660460 0.0000057 0.0007752
CPE 0.5652087 0.0001208 0.0046461
ABO 0.5647148 0.0000169 0.0014221
BACE2-IT1 0.5637973 0.0022528 0.0254731
RP11-554D13.1 0.5629611 0.0060048 0.0461318
PSORS1C1 0.5608379 0.0051067 0.0419715
RP3-342P20.2 0.5603868 0.0000796 0.0036006
JPH2 0.5601865 0.0012032 0.0177501
AF131215.4 0.5587864 0.0000001 0.0000536
PLAT 0.5580129 0.0012985 0.0185031
MSLN 0.5576314 0.0000032 0.0005681
NDUFB8P2 0.5574481 0.0021651 0.0249220
GPR37 0.5561644 0.0003205 0.0080581
RP11-534P19.1 0.5545697 0.0046406 0.0396764
AC017060.1 0.5533333 0.0005884 0.0113528
AC009061.1 0.5531123 0.0004010 0.0091407
RPS16P5 0.5518405 0.0000625 0.0031779
CTD-2201E18.5 0.5511306 0.0022534 0.0254731
RP11-555K12.2 0.5511138 0.0066352 0.0490284
CHAD 0.5510209 0.0000543 0.0029294
BHLHA15 0.5503049 0.0010218 0.0159781
AC114737.3 0.5494690 0.0007919 0.0136089
C1orf64 0.5492243 0.0046336 0.0396561
AC091171.1 0.5492018 0.0004867 0.0101666
STEAP3-AS1 0.5467683 0.0013243 0.0186633
PDCL3P6 0.5466952 0.0041412 0.0369561
AC015987.1 0.5464583 0.0007862 0.0135833
RP13-870H17.3 0.5459774 0.0009544 0.0153929
CTD-2547L24.4 0.5459735 0.0063446 0.0477885
RP11-680G24.4 0.5449092 0.0040439 0.0363866
FTLP14 0.5435340 0.0012977 0.0185015
CTA-331F8.1 0.5412948 0.0017231 0.0216636
RP11-317F20.2 0.5395444 0.0003681 0.0086214
RP1-168P16.1 0.5394518 0.0027531 0.0287532
LCN2 0.5391316 0.0015233 0.0202679
RP11-99A1.2 0.5390547 0.0000056 0.0007711
BTNL9 0.5387906 0.0011193 0.0169565
RP11-214O1.3 0.5385319 0.0003153 0.0079869
XBP1P1 0.5381186 0.0003394 0.0082711
RP11-21A7A.3 0.5374270 0.0020428 0.0241081
RP11-982M15.8 0.5353255 0.0022764 0.0256514
RTEL1-TNFRSF6B 0.5348836 0.0000468 0.0026593
RP11-241J12.3 0.5344845 0.0012507 0.0181433
IL1R2 0.5343087 0.0022972 0.0258175
CTD-2555A7.2 0.5332711 0.0052197 0.0424117
HCG20 0.5328531 0.0045142 0.0390235
RP11-327F22.6 0.5318638 0.0063726 0.0479036
RP11-34P13.13 0.5315750 0.0000275 0.0018786
CYP1B1-AS1 0.5315748 0.0016838 0.0213630
RP11-318K15.2 0.5314635 0.0006216 0.0116919
AC026806.2 0.5310165 0.0000008 0.0002426
RP11-1396O13.2 0.5301164 0.0016456 0.0212110
RP11-449P15.1 0.5300198 0.0005871 0.0113420
NKX3-1 0.5288490 0.0020963 0.0244481
HSD11B2 0.5277233 0.0001276 0.0047993
KLF7-IT1 0.5277020 0.0000275 0.0018786
RP11-206L10.3 0.5274511 0.0000180 0.0014607
ALDH1L2 0.5271217 0.0003375 0.0082498
RP11-68I3.11 0.5252756 0.0000564 0.0029806
AC139426.2 0.5245291 0.0001720 0.0057243
RP11-356M20.3 0.5233429 0.0004226 0.0093351
PDPK2 0.5219127 0.0000106 0.0011099
RP11-384C4.6 0.5215964 0.0000887 0.0038302
CTD-3222D19.5 0.5213488 0.0042189 0.0373421
GRM8 0.5205974 0.0022475 0.0254600
RP11-158M2.5 0.5205745 0.0055090 0.0437515
LINC01002 0.5194631 0.0011715 0.0174781
OMP 0.5187381 0.0046976 0.0399109
RP11-553A21.3 0.5182660 0.0055072 0.0437513
RP11-443F16.1 0.5181958 0.0020657 0.0242722
AP000347.4 0.5180575 0.0013345 0.0187456
RP11-231C14.4 0.5180177 0.0000414 0.0025355
CTB-181H17.1 0.5175276 0.0001863 0.0059830
AC000089.3 0.5168444 0.0000009 0.0002534
CTD-2619J13.8 0.5165587 0.0051089 0.0419715
RP11-453A12.1 0.5162805 0.0027785 0.0289363
RP11-422N16.3 0.5149038 0.0000462 0.0026553
RP11-458F8.4 0.5148342 0.0015087 0.0201796
HMSD 0.5148289 0.0018162 0.0223798
CTB-131B5.2 0.5146960 0.0001450 0.0051884
RP11-305L7.5 0.5146866 0.0033579 0.0323840
GJA6P 0.5146277 0.0002493 0.0069157
SYT8 0.5140831 0.0000748 0.0035025
FOXA3 0.5140588 0.0001090 0.0043815
AC010525.7 0.5138022 0.0001906 0.0060443
RAB43 0.5137079 0.0000003 0.0001463
RP1-308E4.1 0.5136772 0.0065726 0.0488182
LINC00930 0.5129701 0.0016766 0.0213349
FUT6 0.5123183 0.0000002 0.0000781
RP11-404P21.5 0.5120947 0.0021083 0.0245224
RP11-392E22.12 0.5120726 0.0000154 0.0013398
RABGAP1L-IT1 0.5120653 0.0000086 0.0009878
SLC25A47P1 0.5119896 0.0000164 0.0013934
RP11-281P23.2 0.5117555 0.0016227 0.0210554
NEK6 0.5112889 0.0000001 0.0000388
RP11-1082L8.1 0.5106343 0.0047585 0.0402320
AC019117.2 0.5103779 0.0007883 0.0135935
CTB-11I22.1 0.5102449 0.0062128 0.0470565
RP11-392E22.5 0.5101933 0.0004160 0.0092992
RP11-305O4.2 0.5101464 0.0003069 0.0079015
RP11-982M15.6 0.5099017 0.0028238 0.0291830
AC138035.2 0.5098157 0.0007431 0.0130941
AK4P4 0.5090954 0.0049702 0.0412850
RP1-313L4.3 0.5090926 0.0060696 0.0464247
RN7SL23P 0.5087898 0.0010104 0.0158478
RP11-365D23.4 0.5074868 0.0016455 0.0212110
ARMC12 0.5071957 0.0029788 0.0301316
ATP10B 0.5065195 0.0026248 0.0279122
SLC16A14 0.5055594 0.0000393 0.0024466
RP11-16E23.3 0.5046668 0.0001399 0.0050487
ANKRD18A.1 0.5043259 0.0000334 0.0021484
TFCP2L1 0.5041815 0.0001626 0.0055436
CDC42EP5 0.5038609 0.0000471 0.0026642
RP11-163G10.2 0.5033655 0.0001262 0.0047751
PKHD1L1 0.5028688 0.0028809 0.0294831
PPIAP10 0.5027406 0.0004188 0.0093152
CTC-251D13.1 0.5026642 0.0009107 0.0149607
SEMA3B 0.5020373 0.0000131 0.0012259
RP1-5O6.4 0.5019920 0.0002717 0.0072760
ANO1 0.5011846 0.0007084 0.0126646
FBXO36-IT1 0.5010788 0.0003155 0.0079869
RPL19P12 0.5007875 0.0002096 0.0062863
AC005831.1 0.5003057 0.0000062 0.0008023
# write.table(resSigUp, "20201112_Down_in_COPD_Bronch.txt", sep = "\t", quote=F)

Checking for overlap between COPD signature

Differentially expressed genes were checked for overlap with the 98 genes from the COPD signature from Steiling et al, 2013

#Preprocessing. Run ahead of time and comment out when knitting Rmd
names(steilingGenes) <- "Names"
steilingSignature <- steilingGenes$Names
steilingUp <- head(steilingSignature,54)

#create mart object, this is for homo sapiens

mart <- useMart(biomart = "ensembl", dataset = "hsapiens_gene_ensembl")

upBM <- getBM(filters= "hgnc_symbol", attributes= c("ensembl_gene_id","hgnc_symbol"),values=steilingUp,mart= mart)

upBM <- upBM[upBM$ensembl_gene_id %in% rownames(assay(seBronch)),]
# write.table(upBM$ensembl_gene_id, "20201102_SteilingUp_Genelist.grp", sep = "\t", quote = F, col.names = F, row.names = F)
steilingDown <- tail(steilingSignature,44)

downBM <- getBM(filters= "hgnc_symbol", attributes= c("ensembl_gene_id","hgnc_symbol"),values=steilingDown,mart= mart)
downBM <- downBM[-32,]
# write.table(downBM$ensembl_gene_id, "20201102_SteilingDown_Genelist.grp", sep = "\t", quote = F, col.names = F, row.names = F)

#Send to GSEA 11/3/2020


#Check for overlap:
upoverlap <- sum(downBM$hgnc_symbol %in% rownames(resSigUp))
upoverlapgenes <- downBM$hgnc_symbol[downBM$hgnc_symbol %in% rownames(resSigUp)]
downoverlap <- sum(upBM$hgnc_symbol %in% rownames(resSigDown))
downoverlapgenes <- upBM$hgnc_symbol[upBM$hgnc_symbol %in% rownames(resSigDown)]

Overall, of the 54 genes associated with increase of COPD status, 0 were differentially expressed in patients considered to be of COPD status. These are: . Of the 44 genes associated with decrease of COPD status, 0 were differentially expressed in patients considered to be of COPD status. These are: .

Overlap with microarray

resSigUp <- read.table("20201112_Down_in_COPD_Bronch.txt", sep = "\t")
rownames(resSigUp)
##   [1] "STC1"           "SLC6A10P"       "Z82214.3"       "BPIFB6"        
##   [5] "CTD-3118D7.1"   "MUC3A"          "APOB"           "PAX6"          
##   [9] "MUC6"           "TPO"            "DPCR1"          "ARHGAP40"      
##  [13] "PCDH15"         "BPIFB2"         "IL17REL"        "CACNA1E"       
##  [17] "GRM7-AS1"       "RP11-167N4.2"   "SLC13A5"        "ALOX15B"       
##  [21] "REG4"           "CREG2"          "EDN2"           "C8orf22"       
##  [25] "SNTG2"          "BMP8A"          "RP11-139K4.2"   "CSF3"          
##  [29] "RP11-138A9.2"   "RP11-157E16.1"  "ANO7"           "PIRT"          
##  [33] "CHRM1"          "RP11-481N16.1"  "SLC25A48"       "RP11-567M16.2" 
##  [37] "AL133373.1"     "C1orf95"        "FAM189A1"       "HKDC1"         
##  [41] "GAPDHP24"       "PXDN"           "ZDHHC4P1"       "CDH15"         
##  [45] "PTHLH"          "RP11-89K21.1"   "LIPG"           "NTRK2"         
##  [49] "SIX3"           "RP11-779P15.2"  "PMS2P10"        "IL19"          
##  [53] "RP11-439L8.3"   "AC012501.2"     "B3GNT6"         "RP11-139K4.4"  
##  [57] "RP11-333O1.1"   "AQP7P1"         "SLCO1B7"        "AL354898.1"    
##  [61] "RP11-687D19.1"  "LEFTY1"         "STXBP5L"        "MICD"          
##  [65] "RP11-507B12.1"  "FLNC"           "CGREF1"         "GOLGA6B"       
##  [69] "SLCO1B3"        "DUSP5P1"        "GOLGA7B.1"      "RP11-16E12.2"  
##  [73] "FEZF1"          "FKBP5"          "NPM1P43"        "RP11-460N11.3" 
##  [77] "ZNF467"         "RP11-395B7.2"   "CTD-2509G16.3"  "U3.80"         
##  [81] "RP11-115D19.1"  "SSPO"           "RP11-439L8.4"   "RP11-139K4.1"  
##  [85] "CDSN"           "CYP17A1"        "EPS8L3"         "SLC6A1"        
##  [89] "AC015987.2"     "FBN2"           "LINC00342"      "RP1-37C10.3"   
##  [93] "RPL21P112"      "FAM177B"        "RP11-838N2.8"   "IDI2-AS1"      
##  [97] "COMP"           "C1QTNF1"        "AZGP1"          "RP11-803D5.4"  
## [101] "EEF1DP5"        "AHSG"           "AC098592.7"     "RP5-914M6.1"   
## [105] "YAP1P1"         "MTND4P12"       "CTB-102L5.8"    "ITGA10"        
## [109] "FIGN"           "RP11-10H3.1"    "LRRC31"         "RP11-386M24.5" 
## [113] "AC144450.2"     "RP11-527N22.1"  "FAM157B"        "CUX2"          
## [117] "RP11-194N12.2"  "RN7SKP151"      "WNT16"          "RP11-80I15.1"  
## [121] "ASNSP3"         "SEMA6B"         "TDGF1P4"        "BCAS2P2"       
## [125] "SLC17A9"        "RPLP0P2"        "ENTPD2"         "WDR72"         
## [129] "GOLGA6L10"      "RNU5E-6P"       "RP11-508M8.1"   "AQP7P3"        
## [133] "RP11-893F2.9"   "GOLGA7B"        "U3.7"           "MUC5AC"        
## [137] "GPR153"         "LDLRAD2"        "DAAM2"          "AC124944.4"    
## [141] "LINC00632"      "LA16c-425C2.1"  "CTD-2530H12.7"  "CTD-2267D19.6" 
## [145] "CTD-3193O13.1"  "CCL24"          "F5"             "RP11-2E11.5"   
## [149] "RN7SL105P"      "AZGP1P1"        "RP4-713A8.1"    "C2CD4A"        
## [153] "AC073218.2"     "PTGS2"          "RP11-5L12.1"    "DOC2B"         
## [157] "AC020907.1"     "ZBTB16"         "AC138035.1"     "DHRSX-IT1"     
## [161] "PHACTR3"        "NANOGP7"        "ELMOD1"         "SERHL2"        
## [165] "RP11-589C21.6"  "BRINP1"         "AC006003.3"     "RP11-259O2.1"  
## [169] "NEAT1"          "KCNN2"          "RPS20P1"        "CYP3A5"        
## [173] "CPNE4"          "RP13-726E6.3"   "RN7SL739P"      "PTPRH"         
## [177] "DNAJC12"        "RP11-386M24.6"  "AC108066.1"     "TNNI3"         
## [181] "REP15"          "RP11-430B1.1"   "AP000695.6"     "Metazoa_SRP.12"
## [185] "ADRA2A"         "TMC7"           "ENTPD8"         "RP11-221J22.2" 
## [189] "FDPSP3"         "AF131215.6"     "TFF1"           "CTD-2589M5.4"  
## [193] "RP11-10J21.4"   "RP11-480G7.1"   "RP4-609E1.2"    "CTC-548K16.6"  
## [197] "RN7SL57P"       "RP11-77H9.5"    "FAM157C"        "RP3-363L9.1"   
## [201] "RP11-47G11.2"   "RP11-74C1.2"    "JAKMIP3"        "RP11-120K24.4" 
## [205] "RP11-435B5.5"   "CTD-2047H16.2"  "CEACAM5"        "AP000889.3"    
## [209] "SPDEF"          "RP5-981O7.2"    "AC078852.2"     "MUC1"          
## [213] "AC007036.4"     "RP11-18F14.4"   "SLC26A2"        "THBS1"         
## [217] "CATSPERB"       "SULT1C2"        "CTB-193M12.3"   "RP11-496D24.2" 
## [221] "AC092168.2"     "RP11-297K8.2"   "PNCK"           "RP11-1191J2.2" 
## [225] "AC008132.13"    "AC112518.3"     "RN7SKP95"       "RP11-864J10.2" 
## [229] "GS1-122H1.3"    "CHCHD4P2"       "KCP"            "ADM2"          
## [233] "VN1R51P"        "SLC25A18"       "RN7SKP24"       "RP11-447H19.3" 
## [237] "UNC5A"          "CTC-244M17.1"   "SERPINB4"       "NID2"          
## [241] "CTD-2589H19.6"  "ADORA3"         "TMEM211"        "RP11-168F9.2"  
## [245] "PRSS16"         "AL627309.1"     "NARF-IT1"       "RP11-1036E20.9"
## [249] "RP11-380J14.1"  "RP11-458F8.2"   "RP11-324E6.6"   "RPS4XP22"      
## [253] "RP11-797A18.4"  "AC016559.1"     "IRAK3"          "SHROOM1"       
## [257] "RP11-3K24.1"    "TCN1"           "MYLK3"          "RP11-164H5.1"  
## [261] "RP11-49O14.3"   "HK2P1"          "AC138517.1"     "RP11-112L18.1" 
## [265] "ATP5A1P3"       "ANKRD36C"       "CTD-2547H18.1"  "PLEKHD1"       
## [269] "RP11-359B20.1"  "RPL7L1P2"       "PYCR1"          "LBX2"          
## [273] "AC005077.14"    "RP11-131K5.1"   "DQX1"           "CTB-11I22.2"   
## [277] "AC110619.1"     "LAP3P1"         "AC144450.1"     "GS1-122H1.1"   
## [281] "RN7SKP239"      "ADAMDEC1"       "RP11-195B21.3"  "RP11-27M24.2"  
## [285] "AP001468.1"     "CXCL2"          "CCDC144NL"      "RP11-100J16.4" 
## [289] "RP11-381G8.1"   "AC097468.4"     "PRKXP1"         "CTHRC1"        
## [293] "RP11-486O13.4"  "RP11-353J17.3"  "ITPKB-IT1"      "RP11-332H18.3" 
## [297] "RP5-1041C10.3"  "CPE"            "ABO"            "BACE2-IT1"     
## [301] "RP11-554D13.1"  "PSORS1C1"       "RP3-342P20.2"   "JPH2"          
## [305] "AF131215.4"     "PLAT"           "MSLN"           "NDUFB8P2"      
## [309] "GPR37"          "RP11-534P19.1"  "AC017060.1"     "AC009061.1"    
## [313] "RPS16P5"        "CTD-2201E18.5"  "RP11-555K12.2"  "CHAD"          
## [317] "BHLHA15"        "AC114737.3"     "C1orf64"        "AC091171.1"    
## [321] "STEAP3-AS1"     "PDCL3P6"        "AC015987.1"     "RP13-870H17.3" 
## [325] "CTD-2547L24.4"  "RP11-680G24.4"  "FTLP14"         "CTA-331F8.1"   
## [329] "RP11-317F20.2"  "RP1-168P16.1"   "LCN2"           "RP11-99A1.2"   
## [333] "BTNL9"          "RP11-214O1.3"   "XBP1P1"         "RP11-21A7A.3"  
## [337] "RP11-982M15.8"  "RTEL1-TNFRSF6B" "RP11-241J12.3"  "IL1R2"         
## [341] "CTD-2555A7.2"   "HCG20"          "RP11-327F22.6"  "RP11-34P13.13" 
## [345] "CYP1B1-AS1"     "RP11-318K15.2"  "AC026806.2"     "RP11-1396O13.2"
## [349] "RP11-449P15.1"  "NKX3-1"         "HSD11B2"        "KLF7-IT1"      
## [353] "RP11-206L10.3"  "ALDH1L2"        "RP11-68I3.11"   "AC139426.2"    
## [357] "RP11-356M20.3"  "PDPK2"          "RP11-384C4.6"   "CTD-3222D19.5" 
## [361] "GRM8"           "RP11-158M2.5"   "LINC01002"      "OMP"           
## [365] "RP11-553A21.3"  "RP11-443F16.1"  "AP000347.4"     "RP11-231C14.4" 
## [369] "CTB-181H17.1"   "AC000089.3"     "CTD-2619J13.8"  "RP11-453A12.1" 
## [373] "RP11-422N16.3"  "RP11-458F8.4"   "HMSD"           "CTB-131B5.2"   
## [377] "RP11-305L7.5"   "GJA6P"          "SYT8"           "FOXA3"         
## [381] "AC010525.7"     "RAB43"          "RP1-308E4.1"    "LINC00930"     
## [385] "FUT6"           "RP11-404P21.5"  "RP11-392E22.12" "RABGAP1L-IT1"  
## [389] "SLC25A47P1"     "RP11-281P23.2"  "NEK6"           "RP11-1082L8.1" 
## [393] "AC019117.2"     "CTB-11I22.1"    "RP11-392E22.5"  "RP11-305O4.2"  
## [397] "RP11-982M15.6"  "AC138035.2"     "AK4P4"          "RP1-313L4.3"   
## [401] "RN7SL23P"       "RP11-365D23.4"  "ARMC12"         "ATP10B"        
## [405] "SLC16A14"       "RP11-16E23.3"   "ANKRD18A.1"     "TFCP2L1"       
## [409] "CDC42EP5"       "RP11-163G10.2"  "PKHD1L1"        "PPIAP10"       
## [413] "CTC-251D13.1"   "SEMA3B"         "RP1-5O6.4"      "ANO1"          
## [417] "FBXO36-IT1"     "RPL19P12"       "AC005831.1"

GSEA, comparison with COPD signature

Gene set enrichment analysis was conducted using genes associated with COPD status from Steiling et al, 2013. The preranked version of GSEA was performed on normalized counts generated from DESeq2. The rank was generated in ascending order of log2 fold change values outputted from DESeq2.

Model used: ~Smoking status + Age + TIN + COPD status

Upregulated Genes in COPD

54 Genes associated with increase in COPD status were used for GSEA.

GSEA <- c(0.685,2.17,0.0,0.0, 0.0)
GSEA <- as.data.frame(as.matrix(GSEA))
rownames(GSEA) <- c("Enrichment Score",
                    "Normalized Enrichment Score",
                    "Nominal p-value",
                    "FDR q-value",
                    "FWER q-value")
colnames(GSEA) <- c("Upregulated in current smokers")

GSEA %>%
  knitr::kable(
    format = "html", align = rep("c", ncol(GSEA) + 1),
    row.names = TRUE
  ) %>%
  kableExtra::kable_styling() %>%
  kableExtra::scroll_box(height = "200px")
Upregulated in current smokers
Enrichment Score 0.685
Normalized Enrichment Score 2.170
Nominal p-value 0.000
FDR q-value 0.000
FWER q-value 0.000
gsea_details1 <- read.csv("/restricted/projectnb/camplab/home/ykoga07/DECAMP/Novartis/Analysis/1stPass/GSEA_Increase_in_COPD_PreRank_Bronch.csv", row.names = 1)
colnames(gsea_details1) <- gsub("\\.", "_", colnames(gsea_details1)) 

gsea_details1 <- merge(upBM, gsea_details1, by.x = "ensembl_gene_id", by.y = "ENSEMBL_GENEID")
gsea_details1 <- gsea_details1[order(gsea_details1$RANK_IN_GENE_LIST),]

gsea_details1 %>%
  knitr::kable(
    format = "html", align = rep("c", ncol(gsea_details1) + 1),
    row.names = FALSE
  ) %>%
  kableExtra::kable_styling() %>%
  kableExtra::scroll_box(height = "300px")
ensembl_gene_id hgnc_symbol RANK_IN_GENE_LIST RANK_METRIC_SCORE RUNNING_ES CORE_ENRICHMENT
ENSG00000111700 SLCO1B3 301 0.788 0.0416 Yes
ENSG00000105388 CEACAM5 369 0.746 0.0871 Yes
ENSG00000134827 TCN1 596 0.646 0.1218 Yes
ENSG00000155850 SLC26A2 672 0.621 0.1592 Yes
ENSG00000073756 PTGS2 936 0.553 0.1870 Yes
ENSG00000133962 CATSPERB 960 0.548 0.2211 Yes
ENSG00000140297 GCNT3 1089 0.531 0.2512 Yes
ENSG00000137440 FGFBP1 1132 0.525 0.2834 Yes
ENSG00000128683 GAD1 1197 0.516 0.3143 Yes
ENSG00000090376 IRAK3 1228 0.510 0.3459 Yes
ENSG00000180438 TPRXL 1312 0.498 0.3751 Yes
ENSG00000169116 PARM1 1343 0.494 0.4056 Yes
ENSG00000115590 IL1R2 1475 0.476 0.4322 Yes
ENSG00000118322 ATP10B 1505 0.473 0.4614 Yes
ENSG00000156535 CD109 1550 0.468 0.4899 Yes
ENSG00000171124 FUT3 1597 0.462 0.5179 Yes
ENSG00000188761 BCL2L15 1729 0.448 0.5427 Yes
ENSG00000114638 UPK1B 1838 0.438 0.5675 Yes
ENSG00000113657 DPYSL3 2472 0.391 0.5748 Yes
ENSG00000176907 TCIM 2502 0.389 0.5987 Yes
ENSG00000144452 ABCA12 2769 0.374 0.6150 Yes
ENSG00000148346 LCN2 2818 0.371 0.6372 Yes
ENSG00000116711 PLA2G4A 2933 0.365 0.6572 Yes
ENSG00000145113 MUC4 3391 0.343 0.6663 Yes
ENSG00000173702 MUC13 3485 0.339 0.6853 Yes
ENSG00000029153 ARNTL2 4272 0.304 0.6828 No
ENSG00000256870 SLC5A8 4939 0.281 0.6822 No
ENSG00000135976 ANKRD36 6183 0.239 0.6631 No
ENSG00000102359 SRPX2 6599 0.227 0.6660 No
ENSG00000244734 HBB 7359 0.207 0.6581 No
ENSG00000108242 CYP2C18 7378 0.207 0.6707 No
ENSG00000147697 GSDMC 9417 0.156 0.6243 No
ENSG00000136231 IGF2BP3 11562 0.116 0.5724 No
ENSG00000156689 GLYATL2 11654 0.115 0.5772 No
ENSG00000148965 SAA4 14316 0.074 0.5083 No
ENSG00000173432 SAA1 14899 0.066 0.4963 No
ENSG00000168412 MTNR1A 16245 0.050 0.4623 No
ENSG00000091137 SLC26A4 17027 0.041 0.4433 No
ENSG00000094755 GABRP 17043 0.040 0.4454 No
ENSG00000243649 CFB 17228 0.038 0.4428 No
ENSG00000134339 SAA2 19266 0.016 0.3875 No
ENSG00000242515 UGT1A10 19307 0.016 0.3874 No
ENSG00000166920 C15orf48 19523 0.014 0.3823 No
ENSG00000131203 IDO1 23639 -0.030 0.2704 No
ENSG00000261857 MIA 24366 -0.038 0.2528 No
ENSG00000197641 SERPINB13 25959 -0.058 0.2125 No
ENSG00000163606 CD200R1 26407 -0.064 0.2042 No
ENSG00000204616 TRIM31 27454 -0.080 0.1803 No
ENSG00000138166 DUSP5 29914 -0.130 0.1206 No
ENSG00000134762 DSC3 30044 -0.133 0.1254 No
ENSG00000123358 NR4A1 30792 -0.154 0.1146 No
ENSG00000170345 FOS 31541 -0.179 0.1052 No
ENSG00000041982 TNC 31618 -0.182 0.1147 No
ENSG00000153802 TMPRSS11D 32061 -0.200 0.1152 No


Downregulated Genes in COPD

44 Genes associated with decrease in COPD status were used for GSEA.

GSEA <- c(0.612,2.11,0.0,0.0, 0.0)
GSEA <- as.data.frame(as.matrix(GSEA))
rownames(GSEA) <- c("Enrichment Score",
                    "Normalized Enrichment Score",
                    "Nominal p-value",
                    "FDR q-value",
                    "FWER q-value")
colnames(GSEA) <- c("Downregulated in current smokers")

GSEA %>%
  knitr::kable(
    format = "html", align = rep("c", ncol(GSEA) + 1),
    row.names = TRUE
  ) %>%
  kableExtra::kable_styling() %>%
  kableExtra::scroll_box(height = "200px")
Downregulated in current smokers
Enrichment Score 0.612
Normalized Enrichment Score 2.110
Nominal p-value 0.000
FDR q-value 0.000
FWER q-value 0.000
gsea_details2 <- read.csv("/restricted/projectnb/camplab/home/ykoga07/DECAMP/Novartis/Analysis/1stPass/GSEA_Decrease_in_COPD_PreRank_Bronch.csv", row.names = 1)
colnames(gsea_details2) <- gsub("\\.", "_", colnames(gsea_details2)) 

gsea_details2 <- merge(downBM, gsea_details2, by.x = "ensembl_gene_id", by.y = "ENSEMBL_GENEID")
gsea_details2 <- gsea_details2[order(gsea_details2$RANK_IN_GENE_LIST),]

gsea_details2 %>%
  knitr::kable(
    format = "html", align = rep("c", ncol(gsea_details2) + 1),
    row.names = FALSE
  ) %>%
  kableExtra::kable_styling() %>%
  kableExtra::scroll_box(height = "300px")
ensembl_gene_id hgnc_symbol RANK_IN_GENE_LIST RANK_METRIC_SCORE RUNNING_ES CORE_ENRICHMENT
ENSG00000039537 C6 2751 0.375 -0.0328 No
ENSG00000177300 CLDN22 6204 0.239 -0.1007 No
ENSG00000185689 C6orf201 6451 0.232 -0.0807 No
ENSG00000166396 SERPINB7 7644 0.200 -0.0906 No
ENSG00000106772 PRUNE2 9489 0.155 -0.1237 No
ENSG00000113448 PDE4D 14795 0.067 -0.2626 No
ENSG00000164265 SCGB3A2 17090 0.040 -0.3214 No
ENSG00000170381 SEMA3E 19154 0.017 -0.3764 No
ENSG00000173376 NDNF 20197 0.007 -0.4044 No
ENSG00000048540 LMO3 20319 0.005 -0.4071 No
ENSG00000170509 HSD17B13 20415 0.004 -0.4093 No
ENSG00000154864 PIEZO2 21873 -0.011 -0.4483 No
ENSG00000186417 GLDN 24474 -0.040 -0.5156 No
ENSG00000173988 LRRC63 26469 -0.065 -0.5632 No
ENSG00000133124 IRS4 27358 -0.078 -0.5786 No
ENSG00000145147 SLIT2 28551 -0.099 -0.6001 Yes
ENSG00000167315 ACAA2 28815 -0.105 -0.5953 Yes
ENSG00000012223 LTF 29206 -0.113 -0.5931 Yes
ENSG00000069122 ADGRF5 29524 -0.121 -0.5880 Yes
ENSG00000149201 CCDC81 29703 -0.125 -0.5785 Yes
ENSG00000147231 RADX 30041 -0.133 -0.5725 Yes
ENSG00000136205 TNS3 30319 -0.141 -0.5640 Yes
ENSG00000198721 ECI2 30579 -0.148 -0.5541 Yes
ENSG00000147570 DNAJC5B 31533 -0.179 -0.5403 Yes
ENSG00000161298 ZNF382 31621 -0.182 -0.5217 Yes
ENSG00000134775 FHOD3 32120 -0.203 -0.5121 Yes
ENSG00000122420 PTGFR 32302 -0.211 -0.4927 Yes
ENSG00000156076 WIF1 32466 -0.220 -0.4719 Yes
ENSG00000081479 LRP2 32750 -0.234 -0.4527 Yes
ENSG00000156284 CLDN8 32791 -0.237 -0.4265 Yes
ENSG00000103647 CORO2B 32820 -0.238 -0.3998 Yes
ENSG00000134443 GRP 32921 -0.243 -0.3746 Yes
ENSG00000197584 KCNMB2 33108 -0.254 -0.3505 Yes
ENSG00000163285 GABRG1 33335 -0.267 -0.3259 Yes
ENSG00000166148 AVPR1A 33537 -0.282 -0.2990 Yes
ENSG00000206538 VGLL3 33600 -0.286 -0.2677 Yes
ENSG00000127990 SGCE 34198 -0.332 -0.2459 Yes
ENSG00000038295 TLL1 34371 -0.349 -0.2104 Yes
ENSG00000242265 PEG10 35044 -0.432 -0.1792 Yes
ENSG00000079819 EPB41L2 35057 -0.434 -0.1295 Yes
ENSG00000113389 NPR3 35084 -0.436 -0.0799 Yes
ENSG00000096006 CRISP3 35302 -0.469 -0.0318 Yes
ENSG00000111341 MGP 35448 -0.497 0.0215 Yes


EnrichR, upregulated genes

## Uploading data to Enrichr... Done.
##   Querying GO_Molecular_Function_2015... Done.
##   Querying GO_Cellular_Component_2015... Done.
##   Querying GO_Biological_Process_2015... Done.
## Parsing results... Done.

GO_Biological_Process_2015

go_biological %>%
  knitr::kable(
    format = "html", align = rep("c", ncol(go_biological) + 1),
    row.names = TRUE
  ) %>%
  kableExtra::kable_styling() %>%
  kableExtra::scroll_box(height = "300px")
Term Overlap P.value Adjusted.P.value Old.P.value Old.Adjusted.P.value Odds.Ratio Combined.Score Genes
1 positive regulation of phosphatidylinositol 3-kinase signaling (GO:0014068) 5/51 0.0041953 1 0 0 4.6796762 25.6156174 NTRK2;CSF3;ADORA3;WNT16;NKX3-1
2 O-glycan processing (GO:0016266) 5/56 0.0062667 1 0 0 4.2618479 21.6182668 MUC1;B3GNT6;MUC3A;MUC5AC;MUC6
3 regulation of phosphatidylinositol 3-kinase signaling (GO:0014066) 5/66 0.0123812 1 0 0 3.6161134 15.8804244 NTRK2;CSF3;ADORA3;WNT16;NKX3-1
4 glucocorticoid biosynthetic process (GO:0006704) 2/10 0.0176287 1 0 0 9.5465394 38.5510798 HSD11B2;CYP17A1
5 positive regulation of steroid hormone secretion (GO:2000833) 2/11 0.0212509 1 0 0 8.6786722 33.4246616 C1QTNF1;NKX3-1
6 digestive system process (GO:0022600) 4/51 0.0218884 1 0 0 3.7437409 14.3078149 CHRM1;TFF1;ADRA2A;MUC6
7 regulation of smooth muscle contraction (GO:0006940) 4/51 0.0218884 1 0 0 3.7437409 14.3078149 EDN2;TNNI3;PTGS2;ADRA2A
8 negative regulation of hydrogen peroxide-induced cell death (GO:1903206) 2/12 0.0251521 1 0 0 7.9554495 29.2984249 GPR37;PYCR1
9 negative regulation of insulin secretion (GO:0046676) 3/31 0.0265911 1 0 0 4.6192932 16.7549945 BMP8A;ADRA2A;STXBP5L
10 negative regulation of response to reactive oxygen species (GO:1901032) 2/13 0.0293193 1 0 0 7.3434918 25.9189276 GPR37;PYCR1
11 maintenance of gastrointestinal epithelium (GO:0030277) 2/13 0.0293193 1 0 0 7.3434918 25.9189276 TFF1;MUC6
12 regulation of hydrogen peroxide-induced cell death (GO:1903205) 2/13 0.0293193 1 0 0 7.3434918 25.9189276 GPR37;PYCR1
13 lipoxygenase pathway (GO:0019372) 2/13 0.0293193 1 0 0 7.3434918 25.9189276 PTGS2;ALOX15B
14 positive regulation of cell fate commitment (GO:0010455) 2/13 0.0293193 1 0 0 7.3434918 25.9189276 PAX6;SPDEF
15 positive regulation of transforming growth factor beta production (GO:0071636) 2/13 0.0293193 1 0 0 7.3434918 25.9189276 PTGS2;THBS1
16 protein O-linked glycosylation (GO:0006493) 5/83 0.0302483 1 0 0 2.8754637 10.0592761 MUC1;B3GNT6;MUC3A;MUC5AC;MUC6
17 female pregnancy (GO:0007565) 5/85 0.0330527 1 0 0 2.8078057 9.5736393 HSD11B2;MUC1;TFCP2L1;ADRA2A;PTHLH
18 prostaglandin biosynthetic process (GO:0001516) 2/14 0.0337395 1 0 0 6.8189567 23.1100332 EDN2;PTGS2
19 negative regulation of smooth muscle contraction (GO:0045986) 2/14 0.0337395 1 0 0 6.8189567 23.1100332 PTGS2;ADRA2A
20 cartilage development involved in endochondral bone morphogenesis (GO:0060351) 2/14 0.0337395 1 0 0 6.8189567 23.1100332 COMP;THBS1
21 prostanoid biosynthetic process (GO:0046457) 2/14 0.0337395 1 0 0 6.8189567 23.1100332 EDN2;PTGS2
22 ossification (GO:0001503) 6/116 0.0353823 1 0 0 2.4689326 8.2500448 SLC26A2;AHSG;BMP8A;STC1;PTHLH;CTHRC1
23 negative regulation of peptide hormone secretion (GO:0090278) 3/35 0.0364310 1 0 0 4.0913740 13.5520062 BMP8A;ADRA2A;STXBP5L
24 ovulation (GO:0030728) 2/15 0.0384004 1 0 0 6.3643596 20.7458237 PTGS2;CYP17A1
25 positive regulation of macrophage derived foam cell differentiation (GO:0010744) 2/15 0.0384004 1 0 0 6.3643596 20.7458237 APOB;ALOX15B
26 negative regulation of interleukin-12 production (GO:0032695) 2/15 0.0384004 1 0 0 6.3643596 20.7458237 IRAK3;THBS1
27 negative regulation of peptide secretion (GO:0002792) 3/36 0.0391442 1 0 0 3.9777247 12.8898316 BMP8A;ADRA2A;STXBP5L
28 epithelial cell maturation (GO:0002070) 2/16 0.0432900 1 0 0 5.9665871 18.7340875 SIX3;TFCP2L1
29 negative regulation of anoikis (GO:2000811) 2/16 0.0432900 1 0 0 5.9665871 18.7340875 NTRK2;CEACAM5
30 glucocorticoid metabolic process (GO:0008211) 2/16 0.0432900 1 0 0 5.9665871 18.7340875 HSD11B2;CYP17A1
31 negative regulation of calcium ion transport (GO:0051926) 3/38 0.0448688 1 0 0 3.7683708 11.6970666 STC1;PTGS2;ADRA2A
32 regulation of steroid hormone secretion (GO:2000831) 2/17 0.0483968 1 0 0 5.6156114 17.0058776 C1QTNF1;NKX3-1
33 purine ribonucleoside bisphosphate metabolic process (GO:0034035) 2/17 0.0483968 1 0 0 5.6156114 17.0058776 SULT1C2;SLC26A2
34 3’-phosphoadenosine 5’-phosphosulfate metabolic process (GO:0050427) 2/17 0.0483968 1 0 0 5.6156114 17.0058776 SULT1C2;SLC26A2
35 epithelial structure maintenance (GO:0010669) 2/17 0.0483968 1 0 0 5.6156114 17.0058776 TFF1;MUC6
36 decidualization (GO:0046697) 2/18 0.0537095 1 0 0 5.3036330 15.5086983 STC1;PTGS2
37 inner ear receptor stereocilium organization (GO:0060122) 2/18 0.0537095 1 0 0 5.3036330 15.5086983 PCDH15;CTHRC1
38 positive regulation of synaptic transmission, glutamatergic (GO:0051968) 2/18 0.0537095 1 0 0 5.3036330 15.5086983 NTRK2;PTGS2
39 regulation of cAMP biosynthetic process (GO:0030817) 5/98 0.0551609 1 0 0 2.4353417 7.0564042 NTRK2;ADORA3;GRM8;ADRA2A;PTHLH
40 positive regulation of lipid transport (GO:0032370) 3/44 0.0643482 1 0 0 3.2545021 8.9285531 C1QTNF1;LIPG;NKX3-1
41 glandular epithelial cell differentiation (GO:0002067) 2/20 0.0649099 1 0 0 4.7732697 13.0537266 PAX6;SPDEF
42 regulation of anoikis (GO:2000209) 2/20 0.0649099 1 0 0 4.7732697 13.0537266 NTRK2;CEACAM5
43 negative regulation of muscle contraction (GO:0045932) 2/20 0.0649099 1 0 0 4.7732697 13.0537266 PTGS2;ADRA2A
44 hydrogen peroxide catabolic process (GO:0042744) 2/20 0.0649099 1 0 0 4.7732697 13.0537266 TPO;PXDN
45 cellular response to interleukin-1 (GO:0071347) 3/45 0.0679171 1 0 0 3.1821798 8.5583702 IRAK3;MYLK3;NKX3-1
46 response to vitamin D (GO:0033280) 2/21 0.0707769 1 0 0 4.5459711 12.0387430 STC1;PTGS2
47 cartilage development (GO:0051216) 4/75 0.0724979 1 0 0 2.5457438 6.6805349 COMP;ZBTB16;BMP8A;THBS1
48 regulation of synaptic transmission, glutamatergic (GO:0051966) 3/47 0.0753177 1 0 0 3.0467679 7.8790655 NTRK2;GRM8;PTGS2
49 regulation of transforming growth factor beta production (GO:0071634) 2/22 0.0768087 1 0 0 4.3393361 11.1366327 PTGS2;THBS1
50 carbohydrate homeostasis (GO:0033500) 6/143 0.0806388 1 0 0 2.0027705 5.0425256 HKDC1;PAX6;BHLHA15;ADRA2A;FOXA3;STXBP5L
51 glucose homeostasis (GO:0042593) 6/143 0.0806388 1 0 0 2.0027705 5.0425256 HKDC1;PAX6;BHLHA15;ADRA2A;FOXA3;STXBP5L
52 positive regulation of leukocyte migration (GO:0002687) 4/78 0.0811389 1 0 0 2.4478306 6.1479535 CCL24;EDN2;ADORA3;THBS1
53 regulation of response to reactive oxygen species (GO:1901031) 2/23 0.0829959 1 0 0 4.1506693 10.3308677 GPR37;PYCR1
54 protein-lipid complex remodeling (GO:0034368) 2/23 0.0829959 1 0 0 4.1506693 10.3308677 LIPG;APOB
55 plasma lipoprotein particle remodeling (GO:0034369) 2/23 0.0829959 1 0 0 4.1506693 10.3308677 LIPG;APOB
56 endocrine process (GO:0050886) 2/23 0.0829959 1 0 0 4.1506693 10.3308677 HSD11B2;EDN2
57 macromolecular complex remodeling (GO:0034367) 2/23 0.0829959 1 0 0 4.1506693 10.3308677 LIPG;APOB
58 regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044) 2/23 0.0829959 1 0 0 4.1506693 10.3308677 HSD11B2;EDN2
59 prostaglandin metabolic process (GO:0006693) 2/23 0.0829959 1 0 0 4.1506693 10.3308677 EDN2;PTGS2
60 prostanoid metabolic process (GO:0006692) 2/23 0.0829959 1 0 0 4.1506693 10.3308677 EDN2;PTGS2
61 positive regulation of blood vessel endothelial cell migration (GO:0043536) 2/23 0.0829959 1 0 0 4.1506693 10.3308677 PTGS2;THBS1
62 regulation of systemic arterial blood pressure by hormone (GO:0001990) 2/23 0.0829959 1 0 0 4.1506693 10.3308677 HSD11B2;EDN2
63 regulation of cAMP metabolic process (GO:0030814) 5/113 0.0891193 1 0 0 2.1120662 5.1065095 NTRK2;ADORA3;GRM8;ADRA2A;PTHLH
64 unsaturated fatty acid biosynthetic process (GO:0006636) 3/51 0.0911233 1 0 0 2.8078057 6.7262158 EDN2;PTGS2;ALOX15B
65 regulation of muscle contraction (GO:0006937) 5/114 0.0916980 1 0 0 2.0935393 5.0019998 EDN2;STC1;TNNI3;PTGS2;ADRA2A
66 regulation of vasoconstriction (GO:0019229) 3/52 0.0952738 1 0 0 2.7538094 6.4742078 EDN2;PTGS2;ADRA2A
67 columnar/cuboidal epithelial cell development (GO:0002066) 2/25 0.0958000 1 0 0 3.8186158 8.9565341 PAX6;SPDEF
68 positive regulation of smooth muscle contraction (GO:0045987) 2/25 0.0958000 1 0 0 3.8186158 8.9565341 EDN2;PTGS2
69 response to testosterone (GO:0033574) 2/25 0.0958000 1 0 0 3.8186158 8.9565341 THBS1;NKX3-1
70 regulation of lipid transport (GO:0032368) 4/83 0.0966088 1 0 0 2.3003709 5.3761630 C1QTNF1;LIPG;THBS1;NKX3-1
71 regulation of cyclic nucleotide biosynthetic process (GO:0030802) 5/116 0.0969693 1 0 0 2.0574438 4.8007583 NTRK2;ADORA3;GRM8;ADRA2A;PTHLH
72 keratinocyte differentiation (GO:0030216) 3/54 0.1038009 1 0 0 2.6518165 6.0071090 CDSN;PAX6;WNT16
73 regulation of purine nucleotide biosynthetic process (GO:1900371) 5/119 0.1051573 1 0 0 2.0055755 4.5171533 NTRK2;ADORA3;GRM8;ADRA2A;PTHLH
74 regulation of nucleotide biosynthetic process (GO:0030808) 5/119 0.1051573 1 0 0 2.0055755 4.5171533 NTRK2;ADORA3;GRM8;ADRA2A;PTHLH
75 multi-multicellular organism process (GO:0044706) 5/121 0.1107996 1 0 0 1.9724255 4.3394001 HSD11B2;MUC1;TFCP2L1;ADRA2A;PTHLH
76 adenylate cyclase-modulating G-protein coupled receptor signaling pathway (GO:0007188) 5/122 0.1136747 1 0 0 1.9562581 4.2537152 GPR37;ADM2;GRM8;ADRA2A;PTHLH
77 negative regulation of oxidative stress-induced cell death (GO:1903202) 2/28 0.1159532 1 0 0 3.4094783 7.3459547 GPR37;PYCR1
78 regulation of neuroblast proliferation (GO:1902692) 2/28 0.1159532 1 0 0 3.4094783 7.3459547 SIX3;PAX6
79 regulation of macrophage derived foam cell differentiation (GO:0010743) 2/28 0.1159532 1 0 0 3.4094783 7.3459547 APOB;ALOX15B
80 negative regulation of hormone secretion (GO:0046888) 3/57 0.1171287 1 0 0 2.5122472 5.3874682 BMP8A;ADRA2A;STXBP5L
81 positive regulation of actin filament polymerization (GO:0030838) 3/57 0.1171287 1 0 0 2.5122472 5.3874682 CCL24;CSF3;CDC42EP5
82 negative regulation of response to oxidative stress (GO:1902883) 2/29 0.1228915 1 0 0 3.2919101 6.9013369 GPR37;PYCR1
83 negative regulation of cellular response to oxidative stress (GO:1900408) 2/29 0.1228915 1 0 0 3.2919101 6.9013369 GPR37;PYCR1
84 regulation of systemic arterial blood pressure (GO:0003073) 2/29 0.1228915 1 0 0 3.2919101 6.9013369 HSD11B2;EDN2
85 pituitary gland development (GO:0021983) 2/29 0.1228915 1 0 0 3.2919101 6.9013369 SIX3;PAX6
86 lens development in camera-type eye (GO:0002088) 2/30 0.1299275 1 0 0 3.1821798 6.4941249 SIX3;PAX6
87 regulation of membrane lipid distribution (GO:0097035) 2/30 0.1299275 1 0 0 3.1821798 6.4941249 ATP10B;ANO7
88 regulation of cell fate commitment (GO:0010453) 2/30 0.1299275 1 0 0 3.1821798 6.4941249 PAX6;SPDEF
89 negative regulation of ion transport (GO:0043271) 4/94 0.1349839 1 0 0 2.0311786 4.0676380 STC1;PTGS2;THBS1;ADRA2A
90 negative regulation of endothelial cell migration (GO:0010596) 2/31 0.1370541 1 0 0 3.0795288 6.1201917 STC1;THBS1
91 positive regulation of muscle contraction (GO:0045933) 2/31 0.1370541 1 0 0 3.0795288 6.1201917 EDN2;PTGS2
92 plasma lipoprotein particle organization (GO:0071827) 2/31 0.1370541 1 0 0 3.0795288 6.1201917 LIPG;APOB
93 positive regulation of response to wounding (GO:1903036) 5/130 0.1379232 1 0 0 1.8358730 3.6369716 CCL24;ADORA3;PTGS2;THBS1;ADRA2A
94 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway (GO:0007193) 3/62 0.1406464 1 0 0 2.3096466 4.5303865 GPR37;GRM8;ADRA2A
95 regulation of adenylate cyclase activity (GO:0045761) 3/62 0.1406464 1 0 0 2.3096466 4.5303865 NTRK2;ADORA3;ADRA2A
96 eye photoreceptor cell development (GO:0042462) 2/32 0.1442646 1 0 0 2.9832936 5.7759738 NTRK2;PAX6
97 activation of adenylate cyclase activity (GO:0007190) 2/32 0.1442646 1 0 0 2.9832936 5.7759738 NTRK2;ADORA3
98 negative regulation of cytokine-mediated signaling pathway (GO:0001960) 2/32 0.1442646 1 0 0 2.9832936 5.7759738 PXDN;IRAK3
99 negative regulation of cAMP biosynthetic process (GO:0030818) 2/32 0.1442646 1 0 0 2.9832936 5.7759738 GRM8;ADRA2A
100 response to purine-containing compound (GO:0014074) 5/132 0.1443166 1 0 0 1.8080567 3.4999387 STC1;PLAT;SLC6A1;PTGS2;CYP17A1
101 regulation of cyclic nucleotide metabolic process (GO:0030799) 5/133 0.1475605 1 0 0 1.7944623 3.4337340 NTRK2;ADORA3;GRM8;ADRA2A;PTHLH
102 negative regulation of cyclic nucleotide biosynthetic process (GO:0030803) 2/33 0.1515521 1 0 0 2.8928907 5.4583800 GRM8;ADRA2A
103 hydrogen peroxide metabolic process (GO:0042743) 2/33 0.1515521 1 0 0 2.8928907 5.4583800 TPO;PXDN
104 protein-lipid complex subunit organization (GO:0071825) 2/33 0.1515521 1 0 0 2.8928907 5.4583800 LIPG;APOB
105 positive regulation of cAMP biosynthetic process (GO:0030819) 3/65 0.1554543 1 0 0 2.2030475 4.1007610 NTRK2;ADORA3;PTHLH
106 bone trabecula formation (GO:0060346) 1/8 0.1558373 1 0 0 5.9665871 11.0915436 FBN2
107 negative regulation of calcium ion-dependent exocytosis (GO:0045955) 1/8 0.1558373 1 0 0 5.9665871 11.0915436 ADRA2A
108 short-term memory (GO:0007614) 1/8 0.1558373 1 0 0 5.9665871 11.0915436 CUX2
109 energy homeostasis (GO:0097009) 1/8 0.1558373 1 0 0 5.9665871 11.0915436 EDN2
110 positive regulation of heat generation (GO:0031652) 1/8 0.1558373 1 0 0 5.9665871 11.0915436 PTGS2
111 nucleoside diphosphate catabolic process (GO:0009134) 1/8 0.1558373 1 0 0 5.9665871 11.0915436 ENTPD2
112 positive regulation of fibroblast migration (GO:0010763) 1/8 0.1558373 1 0 0 5.9665871 11.0915436 THBS1
113 regulation of dendritic cell antigen processing and presentation (GO:0002604) 1/8 0.1558373 1 0 0 5.9665871 11.0915436 THBS1
114 proline biosynthetic process (GO:0006561) 1/8 0.1558373 1 0 0 5.9665871 11.0915436 PYCR1
115 regulation of fever generation (GO:0031620) 1/8 0.1558373 1 0 0 5.9665871 11.0915436 PTGS2
116 regulation of sarcomere organization (GO:0060297) 1/8 0.1558373 1 0 0 5.9665871 11.0915436 MYLK3
117 C4-dicarboxylate transport (GO:0015740) 1/8 0.1558373 1 0 0 5.9665871 11.0915436 SLC13A5
118 cornea development in camera-type eye (GO:0061303) 1/8 0.1558373 1 0 0 5.9665871 11.0915436 PAX6
119 very-low-density lipoprotein particle assembly (GO:0034379) 1/8 0.1558373 1 0 0 5.9665871 11.0915436 APOB
120 sequestering of extracellular ligand from receptor (GO:0035581) 1/8 0.1558373 1 0 0 5.9665871 11.0915436 FBN2
121 artery smooth muscle contraction (GO:0014824) 1/8 0.1558373 1 0 0 5.9665871 11.0915436 EDN2
122 response to methylmercury (GO:0051597) 1/8 0.1558373 1 0 0 5.9665871 11.0915436 CYP17A1
123 regulation of transforming growth factor beta1 production (GO:0032908) 1/8 0.1558373 1 0 0 5.9665871 11.0915436 THBS1
124 neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976) 1/8 0.1558373 1 0 0 5.9665871 11.0915436 TNNI3
125 positive regulation of vesicle fusion (GO:0031340) 1/8 0.1558373 1 0 0 5.9665871 11.0915436 DOC2B
126 skin morphogenesis (GO:0043589) 1/8 0.1558373 1 0 0 5.9665871 11.0915436 CDSN
127 chondrocyte proliferation (GO:0035988) 1/8 0.1558373 1 0 0 5.9665871 11.0915436 STC1
128 positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316) 1/8 0.1558373 1 0 0 5.9665871 11.0915436 JPH2
129 negative regulation of fatty acid transport (GO:2000192) 1/8 0.1558373 1 0 0 5.9665871 11.0915436 THBS1
130 righting reflex (GO:0060013) 1/8 0.1558373 1 0 0 5.9665871 11.0915436 PCDH15
131 positive regulation of chemokine secretion (GO:0090197) 1/8 0.1558373 1 0 0 5.9665871 11.0915436 ALOX15B
132 receptor recycling (GO:0001881) 1/8 0.1558373 1 0 0 5.9665871 11.0915436 REP15
133 cellular response to ATP (GO:0071318) 1/8 0.1558373 1 0 0 5.9665871 11.0915436 PTGS2
134 histamine secretion (GO:0001821) 1/8 0.1558373 1 0 0 5.9665871 11.0915436 ADORA3
135 intestinal epithelial cell development (GO:0060576) 1/8 0.1558373 1 0 0 5.9665871 11.0915436 SPDEF
136 positive regulation of dendritic spine morphogenesis (GO:0061003) 1/8 0.1558373 1 0 0 5.9665871 11.0915436 CUX2
137 negative regulation of norepinephrine secretion (GO:0010700) 1/8 0.1558373 1 0 0 5.9665871 11.0915436 ADRA2A
138 low-density lipoprotein particle clearance (GO:0034383) 1/8 0.1558373 1 0 0 5.9665871 11.0915436 APOB
139 negative regulation of synaptic transmission, GABAergic (GO:0032229) 1/8 0.1558373 1 0 0 5.9665871 11.0915436 SLC6A1
140 photoreceptor cell development (GO:0042461) 2/34 0.1589105 1 0 0 2.8078057 5.1647173 NTRK2;PAX6
141 regulation of calcium ion-dependent exocytosis (GO:0017158) 2/34 0.1589105 1 0 0 2.8078057 5.1647173 DOC2B;ADRA2A
142 positive regulation of angiogenesis (GO:0045766) 4/101 0.1621454 1 0 0 1.8904038 3.4391397 CCL24;ADM2;PTGS2;THBS1
143 negative regulation of purine nucleotide biosynthetic process (GO:1900372) 2/35 0.1663335 1 0 0 2.7275827 4.8926297 GRM8;ADRA2A
144 nucleoside bisphosphate metabolic process (GO:0033865) 2/35 0.1663335 1 0 0 2.7275827 4.8926297 SULT1C2;SLC26A2
145 regulation of endocrine process (GO:0044060) 2/35 0.1663335 1 0 0 2.7275827 4.8926297 C1QTNF1;NKX3-1
146 ribonucleoside bisphosphate metabolic process (GO:0033875) 2/35 0.1663335 1 0 0 2.7275827 4.8926297 SULT1C2;SLC26A2
147 purine nucleoside bisphosphate metabolic process (GO:0034032) 2/35 0.1663335 1 0 0 2.7275827 4.8926297 SULT1C2;SLC26A2
148 negative regulation of nucleotide biosynthetic process (GO:0030809) 2/35 0.1663335 1 0 0 2.7275827 4.8926297 GRM8;ADRA2A
149 multi-organism reproductive process (GO:0044703) 5/140 0.1711062 1 0 0 1.7047392 3.0096678 HSD11B2;MUC1;TFCP2L1;ADRA2A;PTHLH
150 gamma-aminobutyric acid transport (GO:0015812) 1/9 0.1735296 1 0 0 5.3036330 9.2888214 SLC6A1
151 positive regulation of tolerance induction (GO:0002645) 1/9 0.1735296 1 0 0 5.3036330 9.2888214 IRAK3
152 fucose catabolic process (GO:0019317) 1/9 0.1735296 1 0 0 5.3036330 9.2888214 FUT6
153 alkaloid metabolic process (GO:0009820) 1/9 0.1735296 1 0 0 5.3036330 9.2888214 CYP3A5
154 L-fucose metabolic process (GO:0042354) 1/9 0.1735296 1 0 0 5.3036330 9.2888214 FUT6
155 positive regulation of hormone biosynthetic process (GO:0046886) 1/9 0.1735296 1 0 0 5.3036330 9.2888214 CYP17A1
156 positive regulation of osteoblast proliferation (GO:0033690) 1/9 0.1735296 1 0 0 5.3036330 9.2888214 CTHRC1
157 mitochondrial calcium ion transport (GO:0006851) 1/9 0.1735296 1 0 0 5.3036330 9.2888214 BHLHA15
158 tonic smooth muscle contraction (GO:0014820) 1/9 0.1735296 1 0 0 5.3036330 9.2888214 EDN2
159 artery development (GO:0060840) 1/9 0.1735296 1 0 0 5.3036330 9.2888214 NKX3-1
160 endocardial cushion development (GO:0003197) 1/9 0.1735296 1 0 0 5.3036330 9.2888214 THBS1
161 adenosine receptor signaling pathway (GO:0001973) 1/9 0.1735296 1 0 0 5.3036330 9.2888214 ADORA3
162 L-fucose catabolic process (GO:0042355) 1/9 0.1735296 1 0 0 5.3036330 9.2888214 FUT6
163 positive regulation of amino acid transport (GO:0051957) 1/9 0.1735296 1 0 0 5.3036330 9.2888214 SLC6A1
164 eosinophil chemotaxis (GO:0048245) 1/9 0.1735296 1 0 0 5.3036330 9.2888214 CCL24
165 regulation of chemokine secretion (GO:0090196) 1/9 0.1735296 1 0 0 5.3036330 9.2888214 ALOX15B
166 glucose 6-phosphate metabolic process (GO:0051156) 1/9 0.1735296 1 0 0 5.3036330 9.2888214 HKDC1
167 negative regulation of homotypic cell-cell adhesion (GO:0034111) 1/9 0.1735296 1 0 0 5.3036330 9.2888214 C1QTNF1
168 positive regulation of mast cell degranulation (GO:0043306) 1/9 0.1735296 1 0 0 5.3036330 9.2888214 ADORA3
169 positive regulation of mast cell activation involved in immune response (GO:0033008) 1/9 0.1735296 1 0 0 5.3036330 9.2888214 ADORA3
170 retinal rod cell development (GO:0046548) 1/9 0.1735296 1 0 0 5.3036330 9.2888214 NTRK2
171 positive regulation of transcription factor import into nucleus (GO:0042993) 2/36 0.1738152 1 0 0 2.6518165 4.6400487 CSF3;PTGS2
172 negative regulation of cAMP metabolic process (GO:0030815) 2/36 0.1738152 1 0 0 2.6518165 4.6400487 GRM8;ADRA2A
173 negative regulation of response to cytokine stimulus (GO:0060761) 2/36 0.1738152 1 0 0 2.6518165 4.6400487 PXDN;IRAK3
174 positive regulation of protein polymerization (GO:0032273) 3/69 0.1759027 1 0 0 2.0753346 3.6065664 CCL24;CSF3;CDC42EP5
175 negative regulation of cyclic nucleotide metabolic process (GO:0030800) 2/37 0.1813500 1 0 0 2.5801458 4.4051511 GRM8;ADRA2A
176 positive regulation of adenylate cyclase activity (GO:0045762) 2/37 0.1813500 1 0 0 2.5801458 4.4051511 NTRK2;ADORA3
177 regulation of muscle system process (GO:0090257) 5/144 0.1851754 1 0 0 1.6573853 2.7951006 EDN2;STC1;TNNI3;PTGS2;ADRA2A
178 response to interleukin-1 (GO:0070555) 3/71 0.1863944 1 0 0 2.0168745 3.3881279 IRAK3;MYLK3;NKX3-1
179 regulation of wound healing (GO:0061041) 4/107 0.1868587 1 0 0 1.7843999 2.9931571 C1QTNF1;PLAT;THBS1;ADRA2A
180 positive regulation of fat cell differentiation (GO:0045600) 2/38 0.1889323 1 0 0 2.5122472 4.1863248 ZBTB16;PTGS2
181 lung alveolus development (GO:0048286) 2/38 0.1889323 1 0 0 2.5122472 4.1863248 EDN2;PTHLH
182 phospholipid scrambling (GO:0017121) 1/10 0.1908519 1 0 0 4.7732697 7.9057641 ANO7
183 regulation of heat generation (GO:0031650) 1/10 0.1908519 1 0 0 4.7732697 7.9057641 PTGS2
184 nucleoside diphosphate biosynthetic process (GO:0009133) 1/10 0.1908519 1 0 0 4.7732697 7.9057641 ENTPD8
185 regulation of uterine smooth muscle contraction (GO:0070472) 1/10 0.1908519 1 0 0 4.7732697 7.9057641 ADRA2A
186 regulation of macrophage chemotaxis (GO:0010758) 1/10 0.1908519 1 0 0 4.7732697 7.9057641 THBS1
187 auditory receptor cell stereocilium organization (GO:0060088) 1/10 0.1908519 1 0 0 4.7732697 7.9057641 PCDH15
188 positive regulation of tumor necrosis factor biosynthetic process (GO:0042535) 1/10 0.1908519 1 0 0 4.7732697 7.9057641 THBS1
189 surfactant homeostasis (GO:0043129) 1/10 0.1908519 1 0 0 4.7732697 7.9057641 PTHLH
190 positive regulation of pseudopodium assembly (GO:0031274) 1/10 0.1908519 1 0 0 4.7732697 7.9057641 CDC42EP5
191 coenzyme catabolic process (GO:0009109) 1/10 0.1908519 1 0 0 4.7732697 7.9057641 ALDH1L2
192 heart contraction (GO:0060047) 1/10 0.1908519 1 0 0 4.7732697 7.9057641 TNNI3
193 cardiac left ventricle morphogenesis (GO:0003214) 1/10 0.1908519 1 0 0 4.7732697 7.9057641 CPE
194 eosinophil migration (GO:0072677) 1/10 0.1908519 1 0 0 4.7732697 7.9057641 CCL24
195 regulation of plasminogen activation (GO:0010755) 1/10 0.1908519 1 0 0 4.7732697 7.9057641 THBS1
196 long-chain fatty acid biosynthetic process (GO:0042759) 1/10 0.1908519 1 0 0 4.7732697 7.9057641 ALOX15B
197 negative regulation of transcription by competitive promoter binding (GO:0010944) 1/10 0.1908519 1 0 0 4.7732697 7.9057641 MUC1
198 positive regulation of macrophage activation (GO:0043032) 1/10 0.1908519 1 0 0 4.7732697 7.9057641 THBS1
199 positive regulation of keratinocyte differentiation (GO:0045618) 1/10 0.1908519 1 0 0 4.7732697 7.9057641 ALOX15B
200 mitochondrion distribution (GO:0048311) 1/10 0.1908519 1 0 0 4.7732697 7.9057641 BHLHA15
201 regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768) 1/10 0.1908519 1 0 0 4.7732697 7.9057641 NKX3-1
202 phospholipid homeostasis (GO:0055091) 1/10 0.1908519 1 0 0 4.7732697 7.9057641 LIPG
203 response to insecticide (GO:0017085) 1/10 0.1908519 1 0 0 4.7732697 7.9057641 CYP17A1
204 histamine transport (GO:0051608) 1/10 0.1908519 1 0 0 4.7732697 7.9057641 ADORA3
205 negative regulation of fibrinolysis (GO:0051918) 1/10 0.1908519 1 0 0 4.7732697 7.9057641 THBS1
206 peripheral nervous system neuron development (GO:0048935) 1/10 0.1908519 1 0 0 4.7732697 7.9057641 NTRK2
207 heart process (GO:0003015) 1/10 0.1908519 1 0 0 4.7732697 7.9057641 TNNI3
208 positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:0036003) 1/10 0.1908519 1 0 0 4.7732697 7.9057641 MUC1
209 regulation of mononuclear cell migration (GO:0071675) 1/10 0.1908519 1 0 0 4.7732697 7.9057641 THBS1
210 positive regulation of blood circulation (GO:1903524) 3/72 0.1917005 1 0 0 1.9888624 3.2852446 EDN2;PTGS2;ADRA2A
211 negative regulation of purine nucleotide metabolic process (GO:1900543) 3/72 0.1917005 1 0 0 1.9888624 3.2852446 GRM8;TNNI3;ADRA2A
212 positive regulation of cAMP metabolic process (GO:0030816) 3/72 0.1917005 1 0 0 1.9888624 3.2852446 NTRK2;ADORA3;PTHLH
213 nucleoside diphosphate metabolic process (GO:0009132) 2/39 0.1965568 1 0 0 2.4478306 3.9821398 ENTPD2;ENTPD8
214 embryo implantation (GO:0007566) 2/39 0.1965568 1 0 0 2.4478306 3.9821398 STC1;PTGS2
215 regulation of oxidative stress-induced cell death (GO:1903201) 2/39 0.1965568 1 0 0 2.4478306 3.9821398 GPR37;PYCR1
216 regulation of cyclase activity (GO:0031279) 3/73 0.1970443 1 0 0 1.9616177 3.1863084 NTRK2;ADORA3;ADRA2A
217 regulation of leukocyte migration (GO:0002685) 4/110 0.1996464 1 0 0 1.7357344 2.7966286 CCL24;EDN2;ADORA3;THBS1
218 response to tumor necrosis factor (GO:0034612) 4/111 0.2039667 1 0 0 1.7200972 2.7346080 APOB;PTGS2;THBS1;NKX3-1
219 bone development (GO:0060348) 2/40 0.2042185 1 0 0 2.3866348 3.7913235 CHAD;STC1
220 anterior/posterior pattern specification (GO:0009952) 5/150 0.2070286 1 0 0 1.5910899 2.5058047 ZBTB16;SIX3;PAX6;FEZF1;NKX3-1
221 regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358) 1/11 0.2078120 1 0 0 4.3393361 6.8176239 ALOX15B
222 proline metabolic process (GO:0006560) 1/11 0.2078120 1 0 0 4.3393361 6.8176239 PYCR1
223 regulation of pseudopodium assembly (GO:0031272) 1/11 0.2078120 1 0 0 4.3393361 6.8176239 CDC42EP5
224 positive regulation of endothelial cell apoptotic process (GO:2000353) 1/11 0.2078120 1 0 0 4.3393361 6.8176239 THBS1
225 low-density lipoprotein particle remodeling (GO:0034374) 1/11 0.2078120 1 0 0 4.3393361 6.8176239 APOB
226 regulation of cardiac muscle cell contraction (GO:0086004) 1/11 0.2078120 1 0 0 4.3393361 6.8176239 STC1
227 dopamine biosynthetic process (GO:0042416) 1/11 0.2078120 1 0 0 4.3393361 6.8176239 GPR37
228 mitotic cell cycle arrest (GO:0071850) 1/11 0.2078120 1 0 0 4.3393361 6.8176239 NKX3-1
229 response to lead ion (GO:0010288) 1/11 0.2078120 1 0 0 4.3393361 6.8176239 SLC6A1
230 replicative senescence (GO:0090399) 1/11 0.2078120 1 0 0 4.3393361 6.8176239 WNT16
231 pinocytosis (GO:0006907) 1/11 0.2078120 1 0 0 4.3393361 6.8176239 AHSG
232 oxidative demethylation (GO:0070989) 1/11 0.2078120 1 0 0 4.3393361 6.8176239 CYP3A5
233 positive regulation of epidermal growth factor-activated receptor activity (GO:0045741) 1/11 0.2078120 1 0 0 4.3393361 6.8176239 ADRA2A
234 basement membrane organization (GO:0071711) 1/11 0.2078120 1 0 0 4.3393361 6.8176239 NID2
235 cellular response to prostaglandin stimulus (GO:0071379) 1/11 0.2078120 1 0 0 4.3393361 6.8176239 APOB
236 regulation of energy homeostasis (GO:2000505) 1/11 0.2078120 1 0 0 4.3393361 6.8176239 BMP8A
237 negative regulation of focal adhesion assembly (GO:0051895) 1/11 0.2078120 1 0 0 4.3393361 6.8176239 THBS1
238 regulation of timing of cell differentiation (GO:0048505) 1/11 0.2078120 1 0 0 4.3393361 6.8176239 PAX6
239 negative regulation of adherens junction organization (GO:1903392) 1/11 0.2078120 1 0 0 4.3393361 6.8176239 THBS1
240 negative regulation of cell junction assembly (GO:1901889) 1/11 0.2078120 1 0 0 4.3393361 6.8176239 THBS1
241 response to peptidoglycan (GO:0032494) 1/11 0.2078120 1 0 0 4.3393361 6.8176239 IRAK3
242 negative regulation of myotube differentiation (GO:0010832) 1/11 0.2078120 1 0 0 4.3393361 6.8176239 CEACAM5
243 regulation of lipoprotein metabolic process (GO:0050746) 1/11 0.2078120 1 0 0 4.3393361 6.8176239 LIPG
244 protein heterotrimerization (GO:0070208) 1/11 0.2078120 1 0 0 4.3393361 6.8176239 C1QTNF1
245 negative regulation of nucleotide metabolic process (GO:0045980) 3/75 0.2078374 1 0 0 1.9093079 2.9995211 GRM8;TNNI3;ADRA2A
246 regulation of exocytosis (GO:0017157) 4/112 0.2083144 1 0 0 1.7047392 2.6742360 ADORA3;DOC2B;ADRA2A;STXBP5L
247 regulation of hormone secretion (GO:0046883) 7/230 0.2090308 1 0 0 1.4527343 2.2739268 C1QTNF1;BMP8A;DOC2B;CACNA1E;ADRA2A;STXBP5L;NKX3-1
248 regulation of chondrocyte differentiation (GO:0032330) 2/41 0.2119125 1 0 0 2.3284242 3.6127403 ZBTB16;PTHLH
249 positive regulation of wound healing (GO:0090303) 2/41 0.2119125 1 0 0 2.3284242 3.6127403 THBS1;ADRA2A
250 epidermal cell differentiation (GO:0009913) 3/76 0.2132832 1 0 0 1.8841854 2.9113198 CDSN;PAX6;WNT16
251 regulation of protein kinase B signaling (GO:0051896) 4/114 0.2170882 1 0 0 1.6748315 2.5582241 NTRK2;CSF3;C1QTNF1;THBS1
252 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger (GO:0007187) 5/153 0.2182608 1 0 0 1.5598921 2.3742563 GPR37;ADM2;GRM8;ADRA2A;PTHLH
253 regulation of lyase activity (GO:0051339) 3/77 0.2187594 1 0 0 1.8597155 2.8263638 NTRK2;ADORA3;ADRA2A
254 fatty acid derivative biosynthetic process (GO:1901570) 2/42 0.2196341 1 0 0 2.2729856 3.4453738 EDN2;PTGS2
255 negative regulation of epithelial cell migration (GO:0010633) 2/42 0.2196341 1 0 0 2.2729856 3.4453738 STC1;THBS1
256 icosanoid biosynthetic process (GO:0046456) 2/42 0.2196341 1 0 0 2.2729856 3.4453738 EDN2;PTGS2
257 sterol transport (GO:0015918) 2/42 0.2196341 1 0 0 2.2729856 3.4453738 LIPG;APOB
258 cholesterol transport (GO:0030301) 2/42 0.2196341 1 0 0 2.2729856 3.4453738 LIPG;APOB
259 positive regulation of protein kinase B signaling (GO:0051897) 3/78 0.2242642 1 0 0 1.8358730 2.7445025 CSF3;C1QTNF1;THBS1
260 axis specification (GO:0009798) 3/78 0.2242642 1 0 0 1.8358730 2.7445025 SIX3;STC1;PAX6
261 extracellular fibril organization (GO:0043206) 1/12 0.2244175 1 0 0 3.9777247 5.9437046 MUC5AC
262 regulation of tolerance induction (GO:0002643) 1/12 0.2244175 1 0 0 3.9777247 5.9437046 IRAK3
263 positive regulation of myeloid leukocyte mediated immunity (GO:0002888) 1/12 0.2244175 1 0 0 3.9777247 5.9437046 ADORA3
264 positive regulation of hormone metabolic process (GO:0032352) 1/12 0.2244175 1 0 0 3.9777247 5.9437046 CYP17A1
265 response to manganese ion (GO:0010042) 1/12 0.2244175 1 0 0 3.9777247 5.9437046 PTGS2
266 lens fiber cell differentiation (GO:0070306) 1/12 0.2244175 1 0 0 3.9777247 5.9437046 SIX3
267 positive regulation of cellular amine metabolic process (GO:0033240) 1/12 0.2244175 1 0 0 3.9777247 5.9437046 GPR37
268 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:1902166) 1/12 0.2244175 1 0 0 3.9777247 5.9437046 MUC1
269 regulation of corticosteroid hormone secretion (GO:2000846) 1/12 0.2244175 1 0 0 3.9777247 5.9437046 C1QTNF1
270 G-protein coupled acetylcholine receptor signaling pathway (GO:0007213) 1/12 0.2244175 1 0 0 3.9777247 5.9437046 CHRM1
271 positive regulation of actin cytoskeleton reorganization (GO:2000251) 1/12 0.2244175 1 0 0 3.9777247 5.9437046 CSF3
272 amino acid import (GO:0043090) 1/12 0.2244175 1 0 0 3.9777247 5.9437046 SLC6A1
273 astrocyte differentiation (GO:0048708) 1/12 0.2244175 1 0 0 3.9777247 5.9437046 PAX6
274 regulation of development, heterochronic (GO:0040034) 1/12 0.2244175 1 0 0 3.9777247 5.9437046 PAX6
275 nonmotile primary cilium assembly (GO:0035058) 1/12 0.2244175 1 0 0 3.9777247 5.9437046 PCDH15
276 regulation of platelet aggregation (GO:0090330) 1/12 0.2244175 1 0 0 3.9777247 5.9437046 C1QTNF1
277 startle response (GO:0001964) 1/12 0.2244175 1 0 0 3.9777247 5.9437046 PCDH15
278 regulation of macrophage cytokine production (GO:0010935) 1/12 0.2244175 1 0 0 3.9777247 5.9437046 IRAK3
279 negative regulation of catecholamine secretion (GO:0033604) 1/12 0.2244175 1 0 0 3.9777247 5.9437046 ADRA2A
280 chemical homeostasis within a tissue (GO:0048875) 1/12 0.2244175 1 0 0 3.9777247 5.9437046 PTHLH
281 interleukin-1-mediated signaling pathway (GO:0070498) 1/12 0.2244175 1 0 0 3.9777247 5.9437046 IRAK3
282 endothelial cell morphogenesis (GO:0001886) 1/12 0.2244175 1 0 0 3.9777247 5.9437046 STC1
283 regulation of cholesterol biosynthetic process (GO:0045540) 1/12 0.2244175 1 0 0 3.9777247 5.9437046 APOB
284 iron coordination entity transport (GO:1901678) 1/12 0.2244175 1 0 0 3.9777247 5.9437046 LCN2
285 positive regulation of leukocyte degranulation (GO:0043302) 1/12 0.2244175 1 0 0 3.9777247 5.9437046 ADORA3
286 positive regulation of mast cell activation (GO:0033005) 1/12 0.2244175 1 0 0 3.9777247 5.9437046 ADORA3
287 determination of adult lifespan (GO:0008340) 1/12 0.2244175 1 0 0 3.9777247 5.9437046 TFCP2L1
288 regulation of receptor binding (GO:1900120) 1/12 0.2244175 1 0 0 3.9777247 5.9437046 NKX3-1
289 linoleic acid metabolic process (GO:0043651) 1/12 0.2244175 1 0 0 3.9777247 5.9437046 ALOX15B
290 mesonephros development (GO:0001823) 1/12 0.2244175 1 0 0 3.9777247 5.9437046 ZBTB16
291 negative regulation of blood coagulation (GO:0030195) 2/43 0.2273788 1 0 0 2.2201254 3.2883123 C1QTNF1;PLAT
292 regulation of organic acid transport (GO:0032890) 2/43 0.2273788 1 0 0 2.2201254 3.2883123 SLC6A1;THBS1
293 negative regulation of hemostasis (GO:1900047) 2/43 0.2273788 1 0 0 2.2201254 3.2883123 C1QTNF1;PLAT
294 regulation of blood coagulation (GO:0030193) 3/79 0.2297959 1 0 0 1.8126341 2.6655940 C1QTNF1;PLAT;THBS1
295 calcium-mediated signaling (GO:0019722) 3/79 0.2297959 1 0 0 1.8126341 2.6655940 NTRK2;EDN2;BHLHA15
296 regulation of hemostasis (GO:1900046) 3/79 0.2297959 1 0 0 1.8126341 2.6655940 C1QTNF1;PLAT;THBS1
297 response to organophosphorus (GO:0046683) 4/118 0.2349238 1 0 0 1.6180575 2.3437466 STC1;PLAT;PTGS2;CYP17A1
298 hormone biosynthetic process (GO:0042446) 2/44 0.2351421 1 0 0 2.1696680 3.1407358 TPO;CYP17A1
299 connective tissue development (GO:0061448) 2/44 0.2351421 1 0 0 2.1696680 3.1407358 COMP;THBS1
300 Leydig cell differentiation (GO:0033327) 1/13 0.2406756 1 0 0 3.6717459 5.2296866 CYP17A1
301 drug catabolic process (GO:0042737) 1/13 0.2406756 1 0 0 3.6717459 5.2296866 CYP3A5
302 thyroid hormone generation (GO:0006590) 1/13 0.2406756 1 0 0 3.6717459 5.2296866 TPO
303 chronic inflammatory response (GO:0002544) 1/13 0.2406756 1 0 0 3.6717459 5.2296866 THBS1
304 establishment of tissue polarity (GO:0007164) 1/13 0.2406756 1 0 0 3.6717459 5.2296866 CTHRC1
305 positive regulation of systemic arterial blood pressure (GO:0003084) 1/13 0.2406756 1 0 0 3.6717459 5.2296866 HSD11B2
306 sulfation (GO:0051923) 1/13 0.2406756 1 0 0 3.6717459 5.2296866 SULT1C2
307 phagocytosis, engulfment (GO:0006911) 1/13 0.2406756 1 0 0 3.6717459 5.2296866 THBS1
308 response to auditory stimulus (GO:0010996) 1/13 0.2406756 1 0 0 3.6717459 5.2296866 NTRK2
309 establishment of planar polarity (GO:0001736) 1/13 0.2406756 1 0 0 3.6717459 5.2296866 CTHRC1
310 positive regulation of fatty acid biosynthetic process (GO:0045723) 1/13 0.2406756 1 0 0 3.6717459 5.2296866 PTGS2
311 calcium-mediated signaling using intracellular calcium source (GO:0035584) 1/13 0.2406756 1 0 0 3.6717459 5.2296866 NTRK2
312 lipoprotein transport (GO:0042953) 1/13 0.2406756 1 0 0 3.6717459 5.2296866 APOB
313 cellular response to antibiotic (GO:0071236) 1/13 0.2406756 1 0 0 3.6717459 5.2296866 CYP17A1
314 lung secretory cell differentiation (GO:0061140) 1/13 0.2406756 1 0 0 3.6717459 5.2296866 SPDEF
315 keratinocyte proliferation (GO:0043616) 1/13 0.2406756 1 0 0 3.6717459 5.2296866 WNT16
316 regulation of cholesterol storage (GO:0010885) 1/13 0.2406756 1 0 0 3.6717459 5.2296866 APOB
317 sulfate transmembrane transport (GO:1902358) 1/13 0.2406756 1 0 0 3.6717459 5.2296866 SLC26A2
318 regulation of lipoprotein particle clearance (GO:0010984) 1/13 0.2406756 1 0 0 3.6717459 5.2296866 LIPG
319 negative regulation of cell fate commitment (GO:0010454) 1/13 0.2406756 1 0 0 3.6717459 5.2296866 SPDEF
320 vascular smooth muscle contraction (GO:0014829) 1/13 0.2406756 1 0 0 3.6717459 5.2296866 EDN2
321 sodium-independent organic anion transport (GO:0043252) 1/13 0.2406756 1 0 0 3.6717459 5.2296866 SLCO1B3
322 branching involved in prostate gland morphogenesis (GO:0060442) 1/13 0.2406756 1 0 0 3.6717459 5.2296866 NKX3-1
323 phenol-containing compound metabolic process (GO:0018958) 3/81 0.2409331 1 0 0 1.7678777 2.5161070 TPO;GPR37;CYP17A1
324 response to hypoxia (GO:0001666) 7/241 0.2426279 1 0 0 1.3864269 1.9634941 HSD11B2;MUC1;STC1;PLAT;PTGS2;THBS1;NKX3-1
325 regulation of interleukin-12 production (GO:0032655) 2/45 0.2429200 1 0 0 2.1214532 3.0019049 IRAK3;THBS1
326 negative regulation of ion transmembrane transport (GO:0034766) 2/45 0.2429200 1 0 0 2.1214532 3.0019049 THBS1;ADRA2A
327 regulation of cellular response to oxidative stress (GO:1900407) 2/45 0.2429200 1 0 0 2.1214532 3.0019049 GPR37;PYCR1
328 regulation of blood vessel endothelial cell migration (GO:0043535) 2/45 0.2429200 1 0 0 2.1214532 3.0019049 PTGS2;THBS1
329 positive regulation of cyclic nucleotide biosynthetic process (GO:0030804) 3/82 0.2465352 1 0 0 1.7463182 2.4452827 NTRK2;ADORA3;PTHLH
330 positive regulation of ossification (GO:0045778) 3/83 0.2521575 1 0 0 1.7252782 2.3769184 FBN2;ZBTB16;CTHRC1
331 response to decreased oxygen levels (GO:0036293) 7/245 0.2552533 1 0 0 1.3637913 1.8622555 HSD11B2;MUC1;STC1;PLAT;PTGS2;THBS1;NKX3-1
332 progesterone metabolic process (GO:0042448) 1/14 0.2565938 1 0 0 3.4094783 4.6377803 CYP17A1
333 adrenergic receptor signaling pathway (GO:0071875) 1/14 0.2565938 1 0 0 3.4094783 4.6377803 ADRA2A
334 cell proliferation in forebrain (GO:0021846) 1/14 0.2565938 1 0 0 3.4094783 4.6377803 SIX3
335 regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:1902165) 1/14 0.2565938 1 0 0 3.4094783 4.6377803 MUC1
336 inositol phosphate-mediated signaling (GO:0048016) 1/14 0.2565938 1 0 0 3.4094783 4.6377803 EDN2
337 response to magnesium ion (GO:0032026) 1/14 0.2565938 1 0 0 3.4094783 4.6377803 THBS1
338 G-protein coupled glutamate receptor signaling pathway (GO:0007216) 1/14 0.2565938 1 0 0 3.4094783 4.6377803 GRM8
339 high-density lipoprotein particle remodeling (GO:0034375) 1/14 0.2565938 1 0 0 3.4094783 4.6377803 LIPG
340 gland morphogenesis (GO:0022612) 1/14 0.2565938 1 0 0 3.4094783 4.6377803 PAX6
341 negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037) 1/14 0.2565938 1 0 0 3.4094783 4.6377803 THBS1
342 purine ribonucleoside diphosphate metabolic process (GO:0009179) 1/14 0.2565938 1 0 0 3.4094783 4.6377803 ENTPD2
343 purine nucleoside diphosphate metabolic process (GO:0009135) 1/14 0.2565938 1 0 0 3.4094783 4.6377803 ENTPD2
344 macrophage chemotaxis (GO:0048246) 1/14 0.2565938 1 0 0 3.4094783 4.6377803 EDN2
345 dorsal/ventral axis specification (GO:0009950) 1/14 0.2565938 1 0 0 3.4094783 4.6377803 PAX6
346 regulation of steroid hormone biosynthetic process (GO:0090030) 1/14 0.2565938 1 0 0 3.4094783 4.6377803 CYP17A1
347 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator (GO:0006978) 1/14 0.2565938 1 0 0 3.4094783 4.6377803 MUC1
348 fibril organization (GO:0097435) 1/14 0.2565938 1 0 0 3.4094783 4.6377803 MUC5AC
349 regulation of fibrinolysis (GO:0051917) 1/14 0.2565938 1 0 0 3.4094783 4.6377803 THBS1
350 positive regulation of steroid biosynthetic process (GO:0010893) 1/14 0.2565938 1 0 0 3.4094783 4.6377803 CYP17A1
351 regulation of actin filament-based movement (GO:1903115) 1/14 0.2565938 1 0 0 3.4094783 4.6377803 STC1
352 reactive oxygen species metabolic process (GO:0072593) 3/84 0.2577982 1 0 0 1.7047392 2.3109072 TPO;PXDN;IL19
353 positive regulation of purine nucleotide biosynthetic process (GO:1900373) 3/84 0.2577982 1 0 0 1.7047392 2.3109072 NTRK2;ADORA3;PTHLH
354 positive regulation of nucleotide biosynthetic process (GO:0030810) 3/84 0.2577982 1 0 0 1.7047392 2.3109072 NTRK2;ADORA3;PTHLH
355 adenylate cyclase-activating G-protein coupled receptor signaling pathway (GO:0007189) 2/47 0.2585036 1 0 0 2.0311786 2.7478708 ADM2;PTHLH
356 negative regulation of coagulation (GO:0050819) 2/47 0.2585036 1 0 0 2.0311786 2.7478708 C1QTNF1;PLAT
357 negative regulation of synaptic transmission (GO:0050805) 2/47 0.2585036 1 0 0 2.0311786 2.7478708 SLC6A1;PTGS2
358 positive regulation of cyclase activity (GO:0031281) 2/47 0.2585036 1 0 0 2.0311786 2.7478708 NTRK2;ADORA3
359 regulation of coagulation (GO:0050818) 3/85 0.2634558 1 0 0 1.6846834 2.2471480 C1QTNF1;PLAT;THBS1
360 regulation of anion transport (GO:0044070) 3/85 0.2634558 1 0 0 1.6846834 2.2471480 STC1;SLC6A1;THBS1
361 regulation of calcium ion transmembrane transport (GO:1903169) 2/48 0.2663018 1 0 0 1.9888624 2.6315136 JPH2;ADRA2A
362 regulation of calcium ion transmembrane transporter activity (GO:1901019) 2/48 0.2663018 1 0 0 1.9888624 2.6315136 JPH2;ADRA2A
363 positive regulation of intrinsic apoptotic signaling pathway (GO:2001244) 2/48 0.2663018 1 0 0 1.9888624 2.6315136 IL19;NKX3-1
364 Rho protein signal transduction (GO:0007266) 2/48 0.2663018 1 0 0 1.9888624 2.6315136 CDC42EP5;ADRA2A
365 positive regulation of calcium ion-dependent exocytosis (GO:0045956) 1/15 0.2721791 1 0 0 3.1821798 4.1409551 DOC2B
366 androgen biosynthetic process (GO:0006702) 1/15 0.2721791 1 0 0 3.1821798 4.1409551 CYP17A1
367 embryonic camera-type eye morphogenesis (GO:0048596) 1/15 0.2721791 1 0 0 3.1821798 4.1409551 PAX6
368 glandular epithelial cell development (GO:0002068) 1/15 0.2721791 1 0 0 3.1821798 4.1409551 PAX6
369 granulocyte differentiation (GO:0030851) 1/15 0.2721791 1 0 0 3.1821798 4.1409551 CSF3
370 sulfate transport (GO:0008272) 1/15 0.2721791 1 0 0 3.1821798 4.1409551 SLC26A2
371 regulation of norepinephrine secretion (GO:0014061) 1/15 0.2721791 1 0 0 3.1821798 4.1409551 ADRA2A
372 positive regulation of cholesterol transport (GO:0032376) 1/15 0.2721791 1 0 0 3.1821798 4.1409551 LIPG
373 regulation of cell migration involved in sprouting angiogenesis (GO:0090049) 1/15 0.2721791 1 0 0 3.1821798 4.1409551 PTGS2
374 regulation of dopamine metabolic process (GO:0042053) 1/15 0.2721791 1 0 0 3.1821798 4.1409551 GPR37
375 positive regulation of epidermal cell differentiation (GO:0045606) 1/15 0.2721791 1 0 0 3.1821798 4.1409551 ALOX15B
376 cyclooxygenase pathway (GO:0019371) 1/15 0.2721791 1 0 0 3.1821798 4.1409551 PTGS2
377 acrosome reaction (GO:0007340) 1/15 0.2721791 1 0 0 3.1821798 4.1409551 SYT8
378 pharyngeal system development (GO:0060037) 1/15 0.2721791 1 0 0 3.1821798 4.1409551 NKX3-1
379 DNA damage response, signal transduction resulting in transcription (GO:0042772) 1/15 0.2721791 1 0 0 3.1821798 4.1409551 MUC1
380 positive regulation of membrane protein ectodomain proteolysis (GO:0051044) 1/15 0.2721791 1 0 0 3.1821798 4.1409551 ADRA2A
381 response to food (GO:0032094) 1/15 0.2721791 1 0 0 3.1821798 4.1409551 HSD11B2
382 negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254) 1/15 0.2721791 1 0 0 3.1821798 4.1409551 MUC1
383 detection of mechanical stimulus involved in sensory perception of sound (GO:0050910) 1/15 0.2721791 1 0 0 3.1821798 4.1409551 PCDH15
384 hair cycle (GO:0042633) 1/15 0.2721791 1 0 0 3.1821798 4.1409551 PTGS2
385 positive regulation of sterol transport (GO:0032373) 1/15 0.2721791 1 0 0 3.1821798 4.1409551 LIPG
386 extracellular negative regulation of signal transduction (GO:1900116) 1/15 0.2721791 1 0 0 3.1821798 4.1409551 FBN2
387 extracellular regulation of signal transduction (GO:1900115) 1/15 0.2721791 1 0 0 3.1821798 4.1409551 FBN2
388 negative regulation of chondrocyte differentiation (GO:0032331) 1/15 0.2721791 1 0 0 3.1821798 4.1409551 PTHLH
389 molting cycle (GO:0042303) 1/15 0.2721791 1 0 0 3.1821798 4.1409551 PTGS2
390 renal system process involved in regulation of blood volume (GO:0001977) 1/15 0.2721791 1 0 0 3.1821798 4.1409551 HSD11B2
391 dicarboxylic acid catabolic process (GO:0043649) 1/15 0.2721791 1 0 0 3.1821798 4.1409551 ALDH1L2
392 negative regulation of platelet activation (GO:0010544) 1/15 0.2721791 1 0 0 3.1821798 4.1409551 C1QTNF1
393 regulation of catecholamine metabolic process (GO:0042069) 1/15 0.2721791 1 0 0 3.1821798 4.1409551 GPR37
394 regulation of response to oxidative stress (GO:1902882) 2/49 0.2740994 1 0 0 1.9482733 2.5215808 GPR37;PYCR1
395 cellular glucose homeostasis (GO:0001678) 2/49 0.2740994 1 0 0 1.9482733 2.5215808 HKDC1;FOXA3
396 positive regulation of exocytosis (GO:0045921) 2/49 0.2740994 1 0 0 1.9482733 2.5215808 ADORA3;DOC2B
397 fatty acid derivative metabolic process (GO:1901568) 3/88 0.2805142 1 0 0 1.6272510 2.0684488 EDN2;PTGS2;ALOX15B
398 positive regulation of inflammatory response (GO:0050729) 3/88 0.2805142 1 0 0 1.6272510 2.0684488 CCL24;ADORA3;PTGS2
399 icosanoid metabolic process (GO:0006690) 3/88 0.2805142 1 0 0 1.6272510 2.0684488 EDN2;PTGS2;ALOX15B
400 regulation of insulin secretion (GO:0050796) 5/169 0.2809033 1 0 0 1.4122100 1.7931463 BMP8A;DOC2B;CACNA1E;ADRA2A;STXBP5L
401 determination of left/right symmetry (GO:0007368) 2/50 0.2818931 1 0 0 1.9093079 2.4176177 LEFTY1;DAAM2
402 negative regulation of wound healing (GO:0061045) 2/50 0.2818931 1 0 0 1.9093079 2.4176177 C1QTNF1;PLAT
403 response to fatty acid (GO:0070542) 2/50 0.2818931 1 0 0 1.9093079 2.4176177 PTGS2;APOB
404 positive regulation of lyase activity (GO:0051349) 2/50 0.2818931 1 0 0 1.9093079 2.4176177 NTRK2;ADORA3
405 tissue homeostasis (GO:0001894) 4/129 0.2855315 1 0 0 1.4800836 1.8551413 AZGP1;TFF1;PTHLH;MUC6
406 cellular response to tumor necrosis factor (GO:0071356) 3/89 0.2862238 1 0 0 1.6089673 2.0127878 APOB;THBS1;NKX3-1
407 fucosylation (GO:0036065) 1/16 0.2874383 1 0 0 2.9832936 3.7194122 FUT6
408 cardiac myofibril assembly (GO:0055003) 1/16 0.2874383 1 0 0 2.9832936 3.7194122 MYLK3
409 negative regulation of bone mineralization (GO:0030502) 1/16 0.2874383 1 0 0 2.9832936 3.7194122 AHSG
410 regulation of tumor necrosis factor biosynthetic process (GO:0042534) 1/16 0.2874383 1 0 0 2.9832936 3.7194122 THBS1
411 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043) 1/16 0.2874383 1 0 0 2.9832936 3.7194122 THBS1
412 thyroid hormone metabolic process (GO:0042403) 1/16 0.2874383 1 0 0 2.9832936 3.7194122 TPO
413 positive regulation of calcium ion import (GO:0090280) 1/16 0.2874383 1 0 0 2.9832936 3.7194122 STC1
414 regulation of cellular senescence (GO:2000772) 1/16 0.2874383 1 0 0 2.9832936 3.7194122 NEK6
415 fucose metabolic process (GO:0006004) 1/16 0.2874383 1 0 0 2.9832936 3.7194122 FUT6
416 plasma lipoprotein particle assembly (GO:0034377) 1/16 0.2874383 1 0 0 2.9832936 3.7194122 APOB
417 reverse cholesterol transport (GO:0043691) 1/16 0.2874383 1 0 0 2.9832936 3.7194122 LIPG
418 behavioral response to pain (GO:0048266) 1/16 0.2874383 1 0 0 2.9832936 3.7194122 THBS1
419 phasic smooth muscle contraction (GO:0014821) 1/16 0.2874383 1 0 0 2.9832936 3.7194122 EDN2
420 columnar/cuboidal epithelial cell differentiation (GO:0002065) 2/51 0.2896796 1 0 0 1.8718705 2.3192094 PAX6;SPDEF
421 regulation of potassium ion transport (GO:0043266) 2/51 0.2896796 1 0 0 1.8718705 2.3192094 KCNN2;ADRA2A
422 negative regulation of transmembrane transport (GO:0034763) 2/51 0.2896796 1 0 0 1.8718705 2.3192094 THBS1;ADRA2A
423 circulatory system process (GO:0003013) 4/130 0.2902174 1 0 0 1.4686984 1.8169632 EDN2;TNNI3;MYLK3;F5
424 response to glucocorticoid (GO:0051384) 4/130 0.2902174 1 0 0 1.4686984 1.8169632 HSD11B2;STC1;PLAT;PTGS2
425 response to cAMP (GO:0051591) 3/90 0.2919426 1 0 0 1.5910899 1.9589468 STC1;PLAT;CYP17A1
426 memory (GO:0007613) 3/90 0.2919426 1 0 0 1.5910899 1.9589468 NTRK2;CUX2;PTGS2
427 positive regulation of epithelial cell differentiation (GO:0030858) 2/52 0.2974559 1 0 0 1.8358730 2.2259765 PAX6;ALOX15B
428 phospholipase C-activating G-protein coupled receptor signaling pathway (GO:0007200) 2/52 0.2974559 1 0 0 1.8358730 2.2259765 CHRM1;ADRA2A
429 positive regulation of lipid biosynthetic process (GO:0046889) 2/52 0.2974559 1 0 0 1.8358730 2.2259765 PTGS2;CYP17A1
430 positive regulation of hormone secretion (GO:0046887) 3/91 0.2976692 1 0 0 1.5736054 1.9068519 C1QTNF1;DOC2B;NKX3-1
431 positive regulation of cyclic nucleotide metabolic process (GO:0030801) 3/91 0.2976692 1 0 0 1.5736054 1.9068519 NTRK2;ADORA3;PTHLH
432 response to oxygen levels (GO:0070482) 7/259 0.3008117 1 0 0 1.2900729 1.5497270 HSD11B2;MUC1;STC1;PLAT;PTGS2;THBS1;NKX3-1
433 cellular modified amino acid catabolic process (GO:0042219) 1/17 0.3023784 1 0 0 2.8078057 3.3583490 ALDH1L2
434 positive regulation of regulated secretory pathway (GO:1903307) 1/17 0.3023784 1 0 0 2.8078057 3.3583490 ADORA3
435 G-protein coupled purinergic receptor signaling pathway (GO:0035588) 1/17 0.3023784 1 0 0 2.8078057 3.3583490 ADORA3
436 azole transport (GO:0045117) 1/17 0.3023784 1 0 0 2.8078057 3.3583490 ADORA3
437 ribonucleoside bisphosphate biosynthetic process (GO:0034030) 1/17 0.3023784 1 0 0 2.8078057 3.3583490 SLC26A2
438 negative regulation of organic acid transport (GO:0032891) 1/17 0.3023784 1 0 0 2.8078057 3.3583490 THBS1
439 cofactor catabolic process (GO:0051187) 1/17 0.3023784 1 0 0 2.8078057 3.3583490 ALDH1L2
440 purine nucleoside bisphosphate biosynthetic process (GO:0034033) 1/17 0.3023784 1 0 0 2.8078057 3.3583490 SLC26A2
441 bone remodeling (GO:0046849) 1/17 0.3023784 1 0 0 2.8078057 3.3583490 WNT16
442 nucleoside bisphosphate biosynthetic process (GO:0033866) 1/17 0.3023784 1 0 0 2.8078057 3.3583490 SLC26A2
443 regulation of cell fate specification (GO:0042659) 1/17 0.3023784 1 0 0 2.8078057 3.3583490 PAX6
444 regulation of vesicle fusion (GO:0031338) 1/17 0.3023784 1 0 0 2.8078057 3.3583490 DOC2B
445 ribonucleoside diphosphate metabolic process (GO:0009185) 1/17 0.3023784 1 0 0 2.8078057 3.3583490 ENTPD2
446 muscle cell migration (GO:0014812) 1/17 0.3023784 1 0 0 2.8078057 3.3583490 PLAT
447 sex differentiation (GO:0007548) 1/17 0.3023784 1 0 0 2.8078057 3.3583490 CYP17A1
448 regulation of endothelial cell migration (GO:0010594) 3/92 0.3034021 1 0 0 1.5565010 1.8564331 STC1;PTGS2;THBS1
449 regulation of blood pressure (GO:0008217) 4/133 0.3043351 1 0 0 1.4355698 1.7077909 HSD11B2;EDN2;ADM2;PTGS2
450 determination of bilateral symmetry (GO:0009855) 2/53 0.3052188 1 0 0 1.8012338 2.1375715 LEFTY1;DAAM2
451 regulation of steroid biosynthetic process (GO:0050810) 2/53 0.3052188 1 0 0 1.8012338 2.1375715 APOB;CYP17A1
452 positive regulation of protein binding (GO:0032092) 2/53 0.3052188 1 0 0 1.8012338 2.1375715 CSF3;CTHRC1
453 granulocyte chemotaxis (GO:0071621) 2/53 0.3052188 1 0 0 1.8012338 2.1375715 CCL24;EDN2
454 regulation of cartilage development (GO:0061035) 2/54 0.3129657 1 0 0 1.7678777 2.0536758 ZBTB16;PTHLH
455 specification of symmetry (GO:0009799) 2/54 0.3129657 1 0 0 1.7678777 2.0536758 LEFTY1;DAAM2
456 gland development (GO:0048732) 6/220 0.3146673 1 0 0 1.3018008 1.5051934 SIX3;PAX6;TFCP2L1;ALOX15B;CYP17A1;NKX3-1
457 cellular response to toxic substance (GO:0097237) 1/18 0.3170060 1 0 0 2.6518165 3.0464985 CYP17A1
458 tetrahydrofolate metabolic process (GO:0046653) 1/18 0.3170060 1 0 0 2.6518165 3.0464985 ALDH1L2
459 negative regulation of calcium ion transmembrane transport (GO:1903170) 1/18 0.3170060 1 0 0 2.6518165 3.0464985 ADRA2A
460 cytokine biosynthetic process (GO:0042089) 1/18 0.3170060 1 0 0 2.6518165 3.0464985 IL19
461 catechol-containing compound biosynthetic process (GO:0009713) 1/18 0.3170060 1 0 0 2.6518165 3.0464985 GPR37
462 negative regulation of cytokine production involved in immune response (GO:0002719) 1/18 0.3170060 1 0 0 2.6518165 3.0464985 IRAK3
463 catecholamine biosynthetic process (GO:0042423) 1/18 0.3170060 1 0 0 2.6518165 3.0464985 GPR37
464 fibrinolysis (GO:0042730) 1/18 0.3170060 1 0 0 2.6518165 3.0464985 PLAT
465 olfactory bulb development (GO:0021772) 1/18 0.3170060 1 0 0 2.6518165 3.0464985 FEZF1
466 telencephalon development (GO:0021537) 1/18 0.3170060 1 0 0 2.6518165 3.0464985 SIX3
467 regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902253) 1/18 0.3170060 1 0 0 2.6518165 3.0464985 MUC1
468 positive regulation of excitatory postsynaptic membrane potential (GO:2000463) 1/18 0.3170060 1 0 0 2.6518165 3.0464985 CUX2
469 cellular response to gonadotropin stimulus (GO:0071371) 1/18 0.3170060 1 0 0 2.6518165 3.0464985 CYP17A1
470 negative regulation of calcium ion transmembrane transporter activity (GO:1901020) 1/18 0.3170060 1 0 0 2.6518165 3.0464985 ADRA2A
471 phospholipid translocation (GO:0045332) 1/18 0.3170060 1 0 0 2.6518165 3.0464985 ATP10B
472 virion assembly (GO:0019068) 1/18 0.3170060 1 0 0 2.6518165 3.0464985 RAB43
473 regulation of antigen processing and presentation (GO:0002577) 1/18 0.3170060 1 0 0 2.6518165 3.0464985 THBS1
474 hindbrain development (GO:0030902) 1/18 0.3170060 1 0 0 2.6518165 3.0464985 PAX6
475 glutamate secretion (GO:0014047) 1/18 0.3170060 1 0 0 2.6518165 3.0464985 NTRK2
476 protein-lipid complex assembly (GO:0065005) 1/18 0.3170060 1 0 0 2.6518165 3.0464985 APOB
477 positive regulation of dendritic spine development (GO:0060999) 1/18 0.3170060 1 0 0 2.6518165 3.0464985 CUX2
478 lipid translocation (GO:0034204) 1/18 0.3170060 1 0 0 2.6518165 3.0464985 ATP10B
479 regulation of mast cell degranulation (GO:0043304) 1/18 0.3170060 1 0 0 2.6518165 3.0464985 ADORA3
480 positive regulation of chondrocyte differentiation (GO:0032332) 1/18 0.3170060 1 0 0 2.6518165 3.0464985 ZBTB16
481 negative regulation of biomineral tissue development (GO:0070168) 1/18 0.3170060 1 0 0 2.6518165 3.0464985 AHSG
482 positive regulation of lipid storage (GO:0010884) 1/18 0.3170060 1 0 0 2.6518165 3.0464985 APOB
483 regulation of synaptic transmission, dopaminergic (GO:0032225) 1/18 0.3170060 1 0 0 2.6518165 3.0464985 PTGS2
484 regulation of Rac GTPase activity (GO:0032314) 1/18 0.3170060 1 0 0 2.6518165 3.0464985 NTRK2
485 protein glycosylation (GO:0006486) 7/264 0.3174937 1 0 0 1.2656397 1.4520649 FUT6;MUC1;B3GNT6;MUC3A;ABO;MUC5AC;MUC6
486 macromolecule glycosylation (GO:0043413) 7/264 0.3174937 1 0 0 1.2656397 1.4520649 FUT6;MUC1;B3GNT6;MUC3A;ABO;MUC5AC;MUC6
487 positive regulation of endothelial cell migration (GO:0010595) 2/55 0.3206937 1 0 0 1.7357344 1.9739967 PTGS2;THBS1
488 arachidonic acid metabolic process (GO:0019369) 2/55 0.3206937 1 0 0 1.7357344 1.9739967 PTGS2;ALOX15B
489 granulocyte migration (GO:0097530) 2/55 0.3206937 1 0 0 1.7357344 1.9739967 CCL24;EDN2
490 positive regulation of leukocyte chemotaxis (GO:0002690) 2/56 0.3284002 1 0 0 1.7047392 1.8982650 EDN2;THBS1
491 positive regulation of neuroblast proliferation (GO:0002052) 1/19 0.3313276 1 0 0 2.5122472 2.7751481 PAX6
492 reflex (GO:0060004) 1/19 0.3313276 1 0 0 2.5122472 2.7751481 PCDH15
493 regulation of fibroblast migration (GO:0010762) 1/19 0.3313276 1 0 0 2.5122472 2.7751481 THBS1
494 cardiac epithelial to mesenchymal transition (GO:0060317) 1/19 0.3313276 1 0 0 2.5122472 2.7751481 WNT16
495 osteoblast development (GO:0002076) 1/19 0.3313276 1 0 0 2.5122472 2.7751481 PTHLH
496 appendage development (GO:0048736) 1/19 0.3313276 1 0 0 2.5122472 2.7751481 COMP
497 positive regulation of calcium ion transmembrane transporter activity (GO:1901021) 1/19 0.3313276 1 0 0 2.5122472 2.7751481 JPH2
498 triglyceride catabolic process (GO:0019433) 1/19 0.3313276 1 0 0 2.5122472 2.7751481 APOB
499 limb development (GO:0060173) 1/19 0.3313276 1 0 0 2.5122472 2.7751481 COMP
500 regulation of membrane protein ectodomain proteolysis (GO:0051043) 1/19 0.3313276 1 0 0 2.5122472 2.7751481 ADRA2A
501 positive regulation of heart rate (GO:0010460) 1/19 0.3313276 1 0 0 2.5122472 2.7751481 EDN2
502 intestinal absorption (GO:0050892) 1/19 0.3313276 1 0 0 2.5122472 2.7751481 ADRA2A
503 glutamine family amino acid biosynthetic process (GO:0009084) 1/19 0.3313276 1 0 0 2.5122472 2.7751481 PYCR1
504 positive regulation of histone acetylation (GO:0035066) 1/19 0.3313276 1 0 0 2.5122472 2.7751481 MUC1
505 regulation of mast cell activation involved in immune response (GO:0033006) 1/19 0.3313276 1 0 0 2.5122472 2.7751481 ADORA3
506 membrane invagination (GO:0010324) 1/19 0.3313276 1 0 0 2.5122472 2.7751481 THBS1
507 response to carbohydrate (GO:0009743) 4/139 0.3327663 1 0 0 1.3736028 1.5113956 APOB;SLC6A1;PTGS2;THBS1
508 Golgi organization (GO:0007030) 2/57 0.3360828 1 0 0 1.6748315 1.8262323 RAB43;BHLHA15
509 neurotransmitter secretion (GO:0007269) 2/57 0.3360828 1 0 0 1.6748315 1.8262323 DOC2B;SLC6A1
510 dicarboxylic acid transport (GO:0006835) 2/57 0.3360828 1 0 0 1.6748315 1.8262323 NTRK2;SLC13A5
511 response to corticosteroid (GO:0031960) 4/140 0.3375210 1 0 0 1.3637913 1.4812513 HSD11B2;STC1;PLAT;PTGS2
512 cell cycle arrest (GO:0007050) 4/140 0.3375210 1 0 0 1.3637913 1.4812513 CGREF1;BRINP1;THBS1;NKX3-1
513 cellular response to hypoxia (GO:0071456) 3/99 0.3435957 1 0 0 1.4464454 1.5452227 STC1;PTGS2;NKX3-1
514 negative regulation of lipid catabolic process (GO:0050995) 1/20 0.3453496 1 0 0 2.3866348 2.5374656 ADRA2A
515 regulation of osteoblast proliferation (GO:0033688) 1/20 0.3453496 1 0 0 2.3866348 2.5374656 CTHRC1
516 regulation of transcription involved in cell fate commitment (GO:0060850) 1/20 0.3453496 1 0 0 2.3866348 2.5374656 PAX6
517 renal system process involved in regulation of systemic arterial blood pressure (GO:0003071) 1/20 0.3453496 1 0 0 2.3866348 2.5374656 HSD11B2
518 positive regulation of organelle assembly (GO:1902117) 1/20 0.3453496 1 0 0 2.3866348 2.5374656 MYLK3
519 neuromuscular synaptic transmission (GO:0007274) 1/20 0.3453496 1 0 0 2.3866348 2.5374656 CHRM1
520 positive regulation of epidermal growth factor receptor signaling pathway (GO:0045742) 1/20 0.3453496 1 0 0 2.3866348 2.5374656 ADRA2A
521 negative regulation of cartilage development (GO:0061037) 1/20 0.3453496 1 0 0 2.3866348 2.5374656 PTHLH
522 acidic amino acid transport (GO:0015800) 1/20 0.3453496 1 0 0 2.3866348 2.5374656 SLC6A1
523 regulation of amino acid transport (GO:0051955) 1/20 0.3453496 1 0 0 2.3866348 2.5374656 SLC6A1
524 cobalamin metabolic process (GO:0009235) 1/20 0.3453496 1 0 0 2.3866348 2.5374656 TCN1
525 regulation of cholesterol metabolic process (GO:0090181) 1/20 0.3453496 1 0 0 2.3866348 2.5374656 APOB
526 negative regulation of striated muscle cell differentiation (GO:0051154) 1/20 0.3453496 1 0 0 2.3866348 2.5374656 CEACAM5
527 response to prostaglandin (GO:0034694) 1/20 0.3453496 1 0 0 2.3866348 2.5374656 APOB
528 plasma lipoprotein particle clearance (GO:0034381) 1/20 0.3453496 1 0 0 2.3866348 2.5374656 APOB
529 activation of protein kinase B activity (GO:0032148) 1/20 0.3453496 1 0 0 2.3866348 2.5374656 ADRA2A
530 regulation of homotypic cell-cell adhesion (GO:0034110) 1/20 0.3453496 1 0 0 2.3866348 2.5374656 C1QTNF1
531 negative regulation of blood vessel endothelial cell migration (GO:0043537) 1/20 0.3453496 1 0 0 2.3866348 2.5374656 THBS1
532 positive regulation of cytoskeleton organization (GO:0051495) 4/142 0.3470374 1 0 0 1.3445830 1.4230026 CCL24;CSF3;CDC42EP5;MYLK3
533 glycosylation (GO:0070085) 7/273 0.3478975 1 0 0 1.2239153 1.2922679 FUT6;MUC1;B3GNT6;MUC3A;ABO;MUC5AC;MUC6
534 positive regulation of secretion (GO:0051047) 7/273 0.3478975 1 0 0 1.2239153 1.2922679 C1QTNF1;ADORA3;DOC2B;SLC6A1;ALOX15B;STXBP5L;NKX3-1
535 response to estradiol (GO:0032355) 3/100 0.3493311 1 0 0 1.4319809 1.5060645 TFF1;SLC6A1;PTGS2
536 unsaturated fatty acid metabolic process (GO:0033559) 3/100 0.3493311 1 0 0 1.4319809 1.5060645 EDN2;PTGS2;ALOX15B
537 positive regulation of ion transport (GO:0043270) 5/186 0.3506516 1 0 0 1.2831370 1.3446791 JPH2;CHRM1;STC1;SLC6A1;ADRA2A
538 positive regulation of osteoblast differentiation (GO:0045669) 2/59 0.3513668 1 0 0 1.6180575 1.6923662 FBN2;CTHRC1
539 acute inflammatory response (GO:0002526) 2/59 0.3513668 1 0 0 1.6180575 1.6923662 AHSG;ADRA2A
540 cellular response to decreased oxygen levels (GO:0036294) 3/101 0.3550613 1 0 0 1.4178029 1.4680850 STC1;PTGS2;NKX3-1
541 regulation of peptide transport (GO:0090087) 6/231 0.3553968 1 0 0 1.2398103 1.2826091 BMP8A;DOC2B;PTGS2;CACNA1E;ADRA2A;STXBP5L
542 regulation of amine transport (GO:0051952) 2/60 0.3589637 1 0 0 1.5910899 1.6301255 SLC6A1;ADRA2A
543 negative regulation of production of molecular mediator of immune response (GO:0002701) 1/21 0.3590782 1 0 0 2.2729856 2.3280260 IRAK3
544 positive regulation of T cell mediated cytotoxicity (GO:0001916) 1/21 0.3590782 1 0 0 2.2729856 2.3280260 AZGP1
545 neutral lipid catabolic process (GO:0046461) 1/21 0.3590782 1 0 0 2.2729856 2.3280260 APOB
546 positive regulation of peptidyl-lysine acetylation (GO:2000758) 1/21 0.3590782 1 0 0 2.2729856 2.3280260 MUC1
547 acylglycerol catabolic process (GO:0046464) 1/21 0.3590782 1 0 0 2.2729856 2.3280260 APOB
548 regulation of insulin-like growth factor receptor signaling pathway (GO:0043567) 1/21 0.3590782 1 0 0 2.2729856 2.3280260 NKX3-1
549 negative regulation of exocytosis (GO:0045920) 1/21 0.3590782 1 0 0 2.2729856 2.3280260 ADRA2A
550 embryonic eye morphogenesis (GO:0048048) 1/21 0.3590782 1 0 0 2.2729856 2.3280260 PAX6
551 C21-steroid hormone metabolic process (GO:0008207) 1/21 0.3590782 1 0 0 2.2729856 2.3280260 CYP17A1
552 regulation of dendritic spine morphogenesis (GO:0061001) 1/21 0.3590782 1 0 0 2.2729856 2.3280260 CUX2
553 mechanoreceptor differentiation (GO:0042490) 1/21 0.3590782 1 0 0 2.2729856 2.3280260 NTRK2
554 positive regulation of dendrite morphogenesis (GO:0050775) 1/21 0.3590782 1 0 0 2.2729856 2.3280260 CUX2
555 positive regulation of ERBB signaling pathway (GO:1901186) 1/21 0.3590782 1 0 0 2.2729856 2.3280260 ADRA2A
556 positive regulation of protein acetylation (GO:1901985) 1/21 0.3590782 1 0 0 2.2729856 2.3280260 MUC1
557 regulation of peptide hormone secretion (GO:0090276) 5/189 0.3631093 1 0 0 1.2627698 1.2792506 BMP8A;DOC2B;CACNA1E;ADRA2A;STXBP5L
558 glial cell differentiation (GO:0010001) 2/61 0.3665279 1 0 0 1.5650065 1.5707667 NTRK2;PAX6
559 sensory perception of smell (GO:0007608) 2/61 0.3665279 1 0 0 1.5650065 1.5707667 OMP;GRM8
560 cholesterol homeostasis (GO:0042632) 2/61 0.3665279 1 0 0 1.5650065 1.5707667 LIPG;APOB
561 response to steroid hormone (GO:0048545) 9/369 0.3691084 1 0 0 1.1642121 1.1603295 HSD11B2;STC1;TFF1;PLAT;SLC6A1;PTGS2;THBS1;CYP17A1;NKX3-1
562 regulation of actin filament polymerization (GO:0030833) 3/104 0.3722086 1 0 0 1.3769047 1.3607960 CCL24;CSF3;CDC42EP5
563 Wnt signaling pathway, planar cell polarity pathway (GO:0060071) 1/22 0.3725196 1 0 0 2.1696680 2.1424725 CTHRC1
564 cochlea morphogenesis (GO:0090103) 1/22 0.3725196 1 0 0 2.1696680 2.1424725 CTHRC1
565 regulation of hormone biosynthetic process (GO:0046885) 1/22 0.3725196 1 0 0 2.1696680 2.1424725 CYP17A1
566 myofibril assembly (GO:0030239) 1/22 0.3725196 1 0 0 2.1696680 2.1424725 MYLK3
567 negative regulation of toll-like receptor signaling pathway (GO:0034122) 1/22 0.3725196 1 0 0 2.1696680 2.1424725 IRAK3
568 negative regulation of amine transport (GO:0051953) 1/22 0.3725196 1 0 0 2.1696680 2.1424725 ADRA2A
569 cytokine metabolic process (GO:0042107) 1/22 0.3725196 1 0 0 2.1696680 2.1424725 IL19
570 mitochondrion localization (GO:0051646) 1/22 0.3725196 1 0 0 2.1696680 2.1424725 BHLHA15
571 signal transduction involved in regulation of gene expression (GO:0023019) 1/22 0.3725196 1 0 0 2.1696680 2.1424725 PAX6
572 apoptotic process involved in development (GO:1902742) 1/22 0.3725196 1 0 0 2.1696680 2.1424725 SIX3
573 cellular response to hydrogen peroxide (GO:0070301) 2/62 0.3740573 1 0 0 1.5397644 1.5141217 TPO;PXDN
574 sterol homeostasis (GO:0055092) 2/62 0.3740573 1 0 0 1.5397644 1.5141217 LIPG;APOB
575 cellular response to retinoic acid (GO:0071300) 2/62 0.3740573 1 0 0 1.5397644 1.5141217 MUC1;BRINP1
576 regulation of peptide secretion (GO:0002791) 5/192 0.3755773 1 0 0 1.2430390 1.2172969 BMP8A;DOC2B;CACNA1E;ADRA2A;STXBP5L
577 cellular response to oxidative stress (GO:0034599) 4/148 0.3755906 1 0 0 1.2900729 1.2633110 TPO;PXDN;PYCR1;WNT16
578 response to transition metal nanoparticle (GO:1990267) 3/106 0.3835932 1 0 0 1.3509254 1.2944199 TFF1;PTGS2;CYP17A1
579 response to ATP (GO:0033198) 1/23 0.3856798 1 0 0 2.0753346 1.9772706 PTGS2
580 oligodendrocyte differentiation (GO:0048709) 1/23 0.3856798 1 0 0 2.0753346 1.9772706 NTRK2
581 cell aggregation (GO:0098743) 1/23 0.3856798 1 0 0 2.0753346 1.9772706 CHAD
582 regulation of establishment of planar polarity (GO:0090175) 1/23 0.3856798 1 0 0 2.0753346 1.9772706 CTHRC1
583 regulation of keratinocyte differentiation (GO:0045616) 1/23 0.3856798 1 0 0 2.0753346 1.9772706 ALOX15B
584 benzene-containing compound metabolic process (GO:0042537) 1/23 0.3856798 1 0 0 2.0753346 1.9772706 CYP17A1
585 positive regulation vascular endothelial growth factor production (GO:0010575) 1/23 0.3856798 1 0 0 2.0753346 1.9772706 PTGS2
586 positive regulation of potassium ion transport (GO:0043268) 1/23 0.3856798 1 0 0 2.0753346 1.9772706 ADRA2A
587 positive regulation of transforming growth factor beta receptor signaling pathway (GO:0030511) 1/23 0.3856798 1 0 0 2.0753346 1.9772706 THBS1
588 positive regulation of NF-kappaB import into nucleus (GO:0042346) 1/23 0.3856798 1 0 0 2.0753346 1.9772706 PTGS2
589 cholesterol efflux (GO:0033344) 1/23 0.3856798 1 0 0 2.0753346 1.9772706 APOB
590 positive regulation of organic acid transport (GO:0032892) 1/23 0.3856798 1 0 0 2.0753346 1.9772706 SLC6A1
591 positive regulation of amine transport (GO:0051954) 1/23 0.3856798 1 0 0 2.0753346 1.9772706 SLC6A1
592 multicellular organism reproduction (GO:0032504) 1/23 0.3856798 1 0 0 2.0753346 1.9772706 CATSPERB
593 regulation of macrophage activation (GO:0043030) 1/23 0.3856798 1 0 0 2.0753346 1.9772706 THBS1
594 regulation of fatty acid transport (GO:2000191) 1/23 0.3856798 1 0 0 2.0753346 1.9772706 THBS1
595 positive regulation of steroid metabolic process (GO:0045940) 1/23 0.3856798 1 0 0 2.0753346 1.9772706 CYP17A1
596 cartilage condensation (GO:0001502) 1/23 0.3856798 1 0 0 2.0753346 1.9772706 CHAD
597 steroid metabolic process (GO:0008202) 6/240 0.3890023 1 0 0 1.1933174 1.1266944 HSD11B2;SLCO1B3;TFCP2L1;APOB;CYP3A5;CYP17A1
598 central nervous system development (GO:0007417) 3/108 0.3949304 1 0 0 1.3259082 1.2318294 SNTG2;ZBTB16;PAX6
599 inorganic anion transmembrane transport (GO:0098661) 3/108 0.3949304 1 0 0 1.3259082 1.2318294 ANO1;SLC26A2;ANO7
600 steroid biosynthetic process (GO:0006694) 3/108 0.3949304 1 0 0 1.3259082 1.2318294 HSD11B2;TFCP2L1;CYP17A1
601 regulation of neural precursor cell proliferation (GO:2000177) 2/65 0.3964187 1 0 0 1.4686984 1.3589636 SIX3;PAX6
602 trabecula formation (GO:0060343) 1/24 0.3985646 1 0 0 1.9888624 1.8295261 FBN2
603 regulation of cell aging (GO:0090342) 1/24 0.3985646 1 0 0 1.9888624 1.8295261 NEK6
604 regulation of epidermal growth factor-activated receptor activity (GO:0007176) 1/24 0.3985646 1 0 0 1.9888624 1.8295261 ADRA2A
605 phospholipid catabolic process (GO:0009395) 1/24 0.3985646 1 0 0 1.9888624 1.8295261 LIPG
606 embryonic hemopoiesis (GO:0035162) 1/24 0.3985646 1 0 0 1.9888624 1.8295261 TPO
607 regulation of actin cytoskeleton reorganization (GO:2000249) 1/24 0.3985646 1 0 0 1.9888624 1.8295261 CSF3
608 adrenal gland development (GO:0030325) 1/24 0.3985646 1 0 0 1.9888624 1.8295261 CYP17A1
609 negative regulation of adenylate cyclase activity (GO:0007194) 1/24 0.3985646 1 0 0 1.9888624 1.8295261 ADRA2A
610 positive regulation of blood coagulation (GO:0030194) 1/24 0.3985646 1 0 0 1.9888624 1.8295261 THBS1
611 sprouting angiogenesis (GO:0002040) 1/24 0.3985646 1 0 0 1.9888624 1.8295261 THBS1
612 bile acid and bile salt transport (GO:0015721) 1/24 0.3985646 1 0 0 1.9888624 1.8295261 SLCO1B3
613 endoderm development (GO:0007492) 1/24 0.3985646 1 0 0 1.9888624 1.8295261 PTHLH
614 cardiac ventricle morphogenesis (GO:0003208) 1/24 0.3985646 1 0 0 1.9888624 1.8295261 CPE
615 carbohydrate phosphorylation (GO:0046835) 1/24 0.3985646 1 0 0 1.9888624 1.8295261 HKDC1
616 protein import into nucleus, translocation (GO:0000060) 1/24 0.3985646 1 0 0 1.9888624 1.8295261 SIX3
617 positive regulation of hemostasis (GO:1900048) 1/24 0.3985646 1 0 0 1.9888624 1.8295261 THBS1
618 response to molecule of bacterial origin (GO:0002237) 6/243 0.4002119 1 0 0 1.1785851 1.0793025 CSF3;IRAK3;APOB;PTGS2;CXCL2;CYP17A1
619 cellular response to oxygen levels (GO:0071453) 3/109 0.4005788 1 0 0 1.3137440 1.2018719 STC1;PTGS2;NKX3-1
620 regulation of bone mineralization (GO:0030500) 2/66 0.4037913 1 0 0 1.4464454 1.3117193 FBN2;AHSG
621 dorsal/ventral pattern formation (GO:0009953) 2/66 0.4037913 1 0 0 1.4464454 1.3117193 SIX3;PAX6
622 multicellular organismal response to stress (GO:0033555) 2/66 0.4037913 1 0 0 1.4464454 1.3117193 THBS1;ADRA2A
623 digestion (GO:0007586) 2/66 0.4037913 1 0 0 1.4464454 1.3117193 ADM2;TFF1
624 negative regulation of epithelial cell proliferation (GO:0050680) 3/110 0.4062124 1 0 0 1.3018008 1.1727652 PAX6;THBS1;NKX3-1
625 vasculogenesis (GO:0001570) 2/67 0.4111207 1 0 0 1.4248566 1.2665099 NTRK2;TNNI3
626 regulation of myeloid leukocyte mediated immunity (GO:0002886) 1/25 0.4111798 1 0 0 1.9093079 1.6968492 ADORA3
627 negative regulation of signal transduction by p53 class mediator (GO:1901797) 1/25 0.4111798 1 0 0 1.9093079 1.6968492 MUC1
628 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage (GO:1902230) 1/25 0.4111798 1 0 0 1.9093079 1.6968492 MUC1
629 regulation of excretion (GO:0044062) 1/25 0.4111798 1 0 0 1.9093079 1.6968492 STC1
630 regulation of T cell mediated cytotoxicity (GO:0001914) 1/25 0.4111798 1 0 0 1.9093079 1.6968492 AZGP1
631 purinergic receptor signaling pathway (GO:0035587) 1/25 0.4111798 1 0 0 1.9093079 1.6968492 ADORA3
632 folic acid-containing compound metabolic process (GO:0006760) 1/25 0.4111798 1 0 0 1.9093079 1.6968492 ALDH1L2
633 negative regulation of cyclase activity (GO:0031280) 1/25 0.4111798 1 0 0 1.9093079 1.6968492 ADRA2A
634 response to iron ion (GO:0010039) 1/25 0.4111798 1 0 0 1.9093079 1.6968492 TFF1
635 positive regulation of cartilage development (GO:0061036) 1/25 0.4111798 1 0 0 1.9093079 1.6968492 ZBTB16
636 positive regulation of calcium-mediated signaling (GO:0050850) 1/25 0.4111798 1 0 0 1.9093079 1.6968492 ADORA3
637 regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314) 1/25 0.4111798 1 0 0 1.9093079 1.6968492 JPH2
638 pancreas development (GO:0031016) 1/25 0.4111798 1 0 0 1.9093079 1.6968492 MSLN
639 negative regulation of cell-matrix adhesion (GO:0001953) 1/25 0.4111798 1 0 0 1.9093079 1.6968492 THBS1
640 regulation of leukocyte degranulation (GO:0043300) 1/25 0.4111798 1 0 0 1.9093079 1.6968492 ADORA3
641 positive regulation of synapse assembly (GO:0051965) 1/25 0.4111798 1 0 0 1.9093079 1.6968492 CUX2
642 response to lithium ion (GO:0010226) 1/25 0.4111798 1 0 0 1.9093079 1.6968492 PTGS2
643 detection of mechanical stimulus involved in sensory perception (GO:0050974) 1/25 0.4111798 1 0 0 1.9093079 1.6968492 PCDH15
644 fatty acid biosynthetic process (GO:0006633) 3/111 0.4118303 1 0 0 1.2900729 1.1444802 EDN2;PTGS2;ALOX15B
645 response to retinoic acid (GO:0032526) 3/111 0.4118303 1 0 0 1.2900729 1.1444802 MUC1;BRINP1;CYP17A1
646 positive regulation of response to external stimulus (GO:0032103) 5/201 0.4129169 1 0 0 1.1873805 1.0502486 CCL24;EDN2;ADORA3;PTGS2;THBS1
647 xenobiotic metabolic process (GO:0006805) 4/156 0.4134666 1 0 0 1.2239153 1.0809356 SULT1C2;SLC26A2;CYP3A5;CYP17A1
648 positive regulation of secretion by cell (GO:1903532) 6/247 0.4151390 1 0 0 1.1594987 1.0193640 C1QTNF1;ADORA3;DOC2B;ALOX15B;STXBP5L;NKX3-1
649 regulation of leukocyte chemotaxis (GO:0002688) 2/68 0.4184056 1 0 0 1.4039028 1.2232262 EDN2;THBS1
650 regulation of lipid biosynthetic process (GO:0046890) 3/113 0.4230156 1 0 0 1.2672397 1.0902650 APOB;PTGS2;CYP17A1
651 positive regulation of acute inflammatory response (GO:0002675) 1/26 0.4235310 1 0 0 1.8358730 1.5772510 PTGS2
652 positive regulation of coagulation (GO:0050820) 1/26 0.4235310 1 0 0 1.8358730 1.5772510 THBS1
653 regulation of the force of heart contraction (GO:0002026) 1/26 0.4235310 1 0 0 1.8358730 1.5772510 EDN2
654 positive regulation of heart contraction (GO:0045823) 1/26 0.4235310 1 0 0 1.8358730 1.5772510 EDN2
655 negative regulation of insulin receptor signaling pathway (GO:0046627) 1/26 0.4235310 1 0 0 1.8358730 1.5772510 AHSG
656 stem cell division (GO:0017145) 1/26 0.4235310 1 0 0 1.8358730 1.5772510 ZBTB16
657 macrophage activation (GO:0042116) 1/26 0.4235310 1 0 0 1.8358730 1.5772510 EDN2
658 positive regulation of vasoconstriction (GO:0045907) 1/26 0.4235310 1 0 0 1.8358730 1.5772510 PTGS2
659 positive regulation of vasodilation (GO:0045909) 1/26 0.4235310 1 0 0 1.8358730 1.5772510 ADRA2A
660 regulation of calcium ion import (GO:0090279) 1/26 0.4235310 1 0 0 1.8358730 1.5772510 STC1
661 positive regulation of cation channel activity (GO:2001259) 1/26 0.4235310 1 0 0 1.8358730 1.5772510 JPH2
662 positive regulation of membrane potential (GO:0045838) 1/26 0.4235310 1 0 0 1.8358730 1.5772510 CUX2
663 prostate gland epithelium morphogenesis (GO:0060740) 1/26 0.4235310 1 0 0 1.8358730 1.5772510 NKX3-1
664 negative regulation of lyase activity (GO:0051350) 1/26 0.4235310 1 0 0 1.8358730 1.5772510 ADRA2A
665 positive regulation of epidermis development (GO:0045684) 1/26 0.4235310 1 0 0 1.8358730 1.5772510 ALOX15B
666 regulation of blood circulation (GO:1903522) 5/204 0.4253023 1 0 0 1.1699190 1.0002283 EDN2;ADORA3;STC1;PTGS2;ADRA2A
667 positive regulation of muscle cell differentiation (GO:0051149) 2/70 0.4328361 1 0 0 1.3637913 1.1420335 CDH15;MYLK3
668 negative regulation of cell adhesion (GO:0007162) 3/115 0.4341277 1 0 0 1.2452008 1.0390162 ADAMDEC1;C1QTNF1;THBS1
669 learning (GO:0007612) 3/115 0.4341277 1 0 0 1.2452008 1.0390162 NTRK2;SLC6A1;PTGS2
670 regulation of vascular permeability (GO:0043114) 1/27 0.4356237 1 0 0 1.7678777 1.4690648 MYLK3
671 temperature homeostasis (GO:0001659) 1/27 0.4356237 1 0 0 1.7678777 1.4690648 EDN2
672 cardiac chamber morphogenesis (GO:0003206) 1/27 0.4356237 1 0 0 1.7678777 1.4690648 CPE
673 negative regulation of lipid transport (GO:0032369) 1/27 0.4356237 1 0 0 1.7678777 1.4690648 THBS1
674 regulation of vascular endothelial growth factor production (GO:0010574) 1/27 0.4356237 1 0 0 1.7678777 1.4690648 PTGS2
675 negative regulation of endothelial cell proliferation (GO:0001937) 1/27 0.4356237 1 0 0 1.7678777 1.4690648 THBS1
676 sarcomere organization (GO:0045214) 1/27 0.4356237 1 0 0 1.7678777 1.4690648 MYLK3
677 cellular response to fatty acid (GO:0071398) 1/27 0.4356237 1 0 0 1.7678777 1.4690648 APOB
678 response to gonadotropin (GO:0034698) 1/27 0.4356237 1 0 0 1.7678777 1.4690648 CYP17A1
679 developmental induction (GO:0031128) 1/27 0.4356237 1 0 0 1.7678777 1.4690648 SIX3
680 regulation of mast cell activation (GO:0033003) 1/27 0.4356237 1 0 0 1.7678777 1.4690648 ADORA3
681 regulation of platelet activation (GO:0010543) 1/27 0.4356237 1 0 0 1.7678777 1.4690648 C1QTNF1
682 neuron migration (GO:0001764) 3/116 0.4396542 1 0 0 1.2344663 1.0144433 NTRK2;PAX6;FEZF1
683 skeletal system development (GO:0001501) 4/162 0.4415524 1 0 0 1.1785851 0.9634445 COMP;AHSG;ZBTB16;PTHLH
684 regulation of response to wounding (GO:1903034) 8/347 0.4421392 1 0 0 1.1004656 0.8981235 CCL24;C1QTNF1;AHSG;ADORA3;PLAT;PTGS2;THBS1;ADRA2A
685 positive regulation of ion transmembrane transport (GO:0034767) 2/72 0.4470730 1 0 0 1.3259082 1.0674003 JPH2;STC1
686 regulation of biomineral tissue development (GO:0070167) 2/72 0.4470730 1 0 0 1.3259082 1.0674003 FBN2;AHSG
687 fear response (GO:0042596) 1/28 0.4474633 1 0 0 1.7047392 1.3708842 ADRA2A
688 long-term memory (GO:0007616) 1/28 0.4474633 1 0 0 1.7047392 1.3708842 NTRK2
689 glycerolipid catabolic process (GO:0046503) 1/28 0.4474633 1 0 0 1.7047392 1.3708842 APOB
690 dopamine metabolic process (GO:0042417) 1/28 0.4474633 1 0 0 1.7047392 1.3708842 GPR37
691 positive regulation of fatty acid metabolic process (GO:0045923) 1/28 0.4474633 1 0 0 1.7047392 1.3708842 PTGS2
692 cell-cell signaling involved in cell fate commitment (GO:0045168) 1/28 0.4474633 1 0 0 1.7047392 1.3708842 SIX3
693 cellular senescence (GO:0090398) 1/28 0.4474633 1 0 0 1.7047392 1.3708842 WNT16
694 negative regulation of innate immune response (GO:0045824) 1/28 0.4474633 1 0 0 1.7047392 1.3708842 IRAK3
695 negative regulation of cellular response to insulin stimulus (GO:1900077) 1/28 0.4474633 1 0 0 1.7047392 1.3708842 AHSG
696 epithelial cell differentiation (GO:0030855) 7/303 0.4503696 1 0 0 1.1027356 0.8796375 MUC1;CDSN;SIX3;PAX6;WNT16;PTHLH;SPDEF
697 cell maturation (GO:0048469) 3/118 0.4506445 1 0 0 1.2135431 0.9672867 SIX3;BHLHA15;TFCP2L1
698 post-translational protein modification (GO:0043687) 5/211 0.4539912 1 0 0 1.1311066 0.8932095 MUC1;B3GNT6;MUC3A;MUC5AC;MUC6
699 regulation of transcription factor import into nucleus (GO:0042990) 2/73 0.4541161 1 0 0 1.3077451 1.0323371 CSF3;PTGS2
700 epithelial cell proliferation (GO:0050673) 2/73 0.4541161 1 0 0 1.3077451 1.0323371 WNT16;NKX3-1
701 cellular response to heat (GO:0034605) 1/29 0.4590552 1 0 0 1.6459551 1.2815157 THBS1
702 regulation of fibroblast growth factor receptor signaling pathway (GO:0040036) 1/29 0.4590552 1 0 0 1.6459551 1.2815157 THBS1
703 lung epithelial cell differentiation (GO:0060487) 1/29 0.4590552 1 0 0 1.6459551 1.2815157 SPDEF
704 vitamin transport (GO:0051180) 1/29 0.4590552 1 0 0 1.6459551 1.2815157 TCN1
705 regulation of fatty acid biosynthetic process (GO:0042304) 1/29 0.4590552 1 0 0 1.6459551 1.2815157 PTGS2
706 non-canonical Wnt signaling pathway (GO:0035567) 1/29 0.4590552 1 0 0 1.6459551 1.2815157 CTHRC1
707 blood vessel morphogenesis (GO:0048514) 2/74 0.4611076 1 0 0 1.2900729 0.9986763 APOB;THBS1
708 regulation of synaptic plasticity (GO:0048167) 3/120 0.4615461 1 0 0 1.1933174 0.9226411 NTRK2;PLAT;PTGS2
709 response to vitamin (GO:0033273) 2/75 0.4680465 1 0 0 1.2728719 0.9663487 STC1;PTGS2
710 platelet-derived growth factor receptor signaling pathway (GO:0048008) 1/30 0.4704044 1 0 0 1.5910899 1.1999403 PLAT
711 positive regulation of multicellular organismal metabolic process (GO:0044253) 1/30 0.4704044 1 0 0 1.5910899 1.1999403 BMP8A
712 regulation of hormone metabolic process (GO:0032350) 1/30 0.4704044 1 0 0 1.5910899 1.1999403 CYP17A1
713 embryonic hindlimb morphogenesis (GO:0035116) 1/30 0.4704044 1 0 0 1.5910899 1.1999403 ZBTB16
714 central nervous system neuron development (GO:0021954) 1/30 0.4704044 1 0 0 1.5910899 1.1999403 NTRK2
715 long-term synaptic potentiation (GO:0060291) 1/30 0.4704044 1 0 0 1.5910899 1.1999403 NTRK2
716 regulation of regulated secretory pathway (GO:1903305) 1/30 0.4704044 1 0 0 1.5910899 1.1999403 ADORA3
717 positive regulation of receptor activity (GO:2000273) 1/30 0.4704044 1 0 0 1.5910899 1.1999403 ADRA2A
718 circadian behavior (GO:0048512) 1/30 0.4704044 1 0 0 1.5910899 1.1999403 SIX3
719 regulation of granulocyte chemotaxis (GO:0071622) 1/30 0.4704044 1 0 0 1.5910899 1.1999403 THBS1
720 endochondral ossification (GO:0001958) 1/30 0.4704044 1 0 0 1.5910899 1.1999403 PTHLH
721 lung cell differentiation (GO:0060479) 1/30 0.4704044 1 0 0 1.5910899 1.1999403 SPDEF
722 vasoconstriction (GO:0042310) 1/30 0.4704044 1 0 0 1.5910899 1.1999403 EDN2
723 photoreceptor cell maintenance (GO:0045494) 1/30 0.4704044 1 0 0 1.5910899 1.1999403 PCDH15
724 replacement ossification (GO:0036075) 1/30 0.4704044 1 0 0 1.5910899 1.1999403 PTHLH
725 regulation of muscle cell differentiation (GO:0051147) 3/122 0.4723536 1 0 0 1.1737548 0.8803484 CEACAM5;CDH15;MYLK3
726 positive regulation of protein complex assembly (GO:0031334) 3/122 0.4723536 1 0 0 1.1737548 0.8803484 CCL24;CSF3;CDC42EP5
727 regulation of actin polymerization or depolymerization (GO:0008064) 3/122 0.4723536 1 0 0 1.1737548 0.8803484 CCL24;CSF3;CDC42EP5
728 myeloid leukocyte migration (GO:0097529) 2/76 0.4749320 1 0 0 1.2561236 0.9352892 CCL24;EDN2
729 regulation of actin filament length (GO:0030832) 3/123 0.4777203 1 0 0 1.1642121 0.8600382 CCL24;CSF3;CDC42EP5
730 regulation of endothelial cell apoptotic process (GO:2000351) 1/31 0.4815161 1 0 0 1.5397644 1.1252839 THBS1
731 phenol-containing compound biosynthetic process (GO:0046189) 1/31 0.4815161 1 0 0 1.5397644 1.1252839 GPR37
732 cellular response to glucocorticoid stimulus (GO:0071385) 1/31 0.4815161 1 0 0 1.5397644 1.1252839 STC1
733 protein kinase B signaling (GO:0043491) 1/31 0.4815161 1 0 0 1.5397644 1.1252839 NKX3-1
734 regulation of mitochondrial membrane potential (GO:0051881) 1/31 0.4815161 1 0 0 1.5397644 1.1252839 PYCR1
735 positive regulation of blood pressure (GO:0045777) 1/31 0.4815161 1 0 0 1.5397644 1.1252839 HSD11B2
736 negative regulation of interleukin-6 production (GO:0032715) 1/31 0.4815161 1 0 0 1.5397644 1.1252839 IRAK3
737 peptide cross-linking (GO:0018149) 1/31 0.4815161 1 0 0 1.5397644 1.1252839 THBS1
738 regulation of steroid metabolic process (GO:0019218) 2/77 0.4817632 1 0 0 1.2398103 0.9054366 APOB;CYP17A1
739 positive regulation of transmembrane transport (GO:0034764) 2/77 0.4817632 1 0 0 1.2398103 0.9054366 JPH2;STC1
740 regulation of calcium ion transport (GO:0051924) 4/171 0.4828810 1 0 0 1.1165543 0.8128349 JPH2;STC1;PTGS2;ADRA2A
741 signal release (GO:0023061) 3/124 0.4830616 1 0 0 1.1548233 0.8402623 ADORA3;DOC2B;SLC6A1
742 anion transmembrane transport (GO:0098656) 4/172 0.4874009 1 0 0 1.1100627 0.7977670 ANO1;SLC26A2;ANO7;SLC13A5
743 positive regulation of leukocyte mediated immunity (GO:0002705) 2/78 0.4885395 1 0 0 1.2239153 0.8767333 AZGP1;ADORA3
744 regulation of tumor necrosis factor production (GO:0032680) 2/78 0.4885395 1 0 0 1.2239153 0.8767333 IRAK3;THBS1
745 cellular response to lipid (GO:0071396) 7/315 0.4907568 1 0 0 1.0607266 0.7550323 CSF3;MUC1;BRINP1;STC1;APOB;CYP17A1;NKX3-1
746 regulation of ossification (GO:0030278) 4/173 0.4919047 1 0 0 1.1036462 0.7830041 FBN2;AHSG;ZBTB16;CTHRC1
747 pteridine-containing compound metabolic process (GO:0042558) 1/32 0.4923952 1 0 0 1.4916468 1.0567925 ALDH1L2
748 regulation of intrinsic apoptotic signaling pathway in response to DNA damage (GO:1902229) 1/32 0.4923952 1 0 0 1.4916468 1.0567925 MUC1
749 reproduction (GO:0000003) 1/32 0.4923952 1 0 0 1.4916468 1.0567925 CATSPERB
750 positive regulation of protein tyrosine kinase activity (GO:0061098) 1/32 0.4923952 1 0 0 1.4916468 1.0567925 ADRA2A
751 positive regulation of nitric oxide biosynthetic process (GO:0045429) 1/32 0.4923952 1 0 0 1.4916468 1.0567925 PTGS2
752 rhythmic behavior (GO:0007622) 1/32 0.4923952 1 0 0 1.4916468 1.0567925 SIX3
753 regulation of potassium ion transmembrane transport (GO:1901379) 1/32 0.4923952 1 0 0 1.4916468 1.0567925 KCNN2
754 brown fat cell differentiation (GO:0050873) 1/32 0.4923952 1 0 0 1.4916468 1.0567925 PTGS2
755 calcium ion import (GO:0070509) 1/32 0.4923952 1 0 0 1.4916468 1.0567925 CACNA1E
756 response to pain (GO:0048265) 1/32 0.4923952 1 0 0 1.4916468 1.0567925 THBS1
757 negative regulation of purine nucleotide catabolic process (GO:0033122) 1/32 0.4923952 1 0 0 1.4916468 1.0567925 TNNI3
758 androgen metabolic process (GO:0008209) 1/32 0.4923952 1 0 0 1.4916468 1.0567925 CYP17A1
759 one-carbon metabolic process (GO:0006730) 1/32 0.4923952 1 0 0 1.4916468 1.0567925 ALDH1L2
760 sulfur compound transport (GO:0072348) 1/32 0.4923952 1 0 0 1.4916468 1.0567925 SLC26A2
761 regulation of synaptic transmission, GABAergic (GO:0032228) 1/32 0.4923952 1 0 0 1.4916468 1.0567925 SLC6A1
762 regulation of intrinsic apoptotic signaling pathway (GO:2001242) 3/126 0.4936654 1 0 0 1.1364928 0.8022473 MUC1;IL19;NKX3-1
763 eye development (GO:0001654) 2/79 0.4952601 1 0 0 1.2084227 0.8491250 SIX3;PAX6
764 positive regulation of epithelial cell migration (GO:0010634) 2/79 0.4952601 1 0 0 1.2084227 0.8491250 PTGS2;THBS1
765 regulation of protein polymerization (GO:0032271) 3/127 0.4989268 1 0 0 1.1275440 0.7839768 CCL24;CSF3;CDC42EP5
766 inorganic anion transport (GO:0015698) 3/127 0.4989268 1 0 0 1.1275440 0.7839768 ANO1;SLC26A2;ANO7
767 positive regulation of protein import into nucleus (GO:0042307) 2/80 0.5019244 1 0 0 1.1933174 0.8225606 CSF3;PTGS2
768 regulation of tumor necrosis factor superfamily cytokine production (GO:1903555) 2/80 0.5019244 1 0 0 1.1933174 0.8225606 IRAK3;THBS1
769 positive regulation of reproductive process (GO:2000243) 1/33 0.5030465 1 0 0 1.4464454 0.9938131 PLAT
770 calcium ion-dependent exocytosis (GO:0017156) 1/33 0.5030465 1 0 0 1.4464454 0.9938131 SYT8
771 negative regulation of nucleotide catabolic process (GO:0030812) 1/33 0.5030465 1 0 0 1.4464454 0.9938131 TNNI3
772 peptide hormone processing (GO:0016486) 1/33 0.5030465 1 0 0 1.4464454 0.9938131 CPE
773 cellular response to corticosteroid stimulus (GO:0071384) 1/33 0.5030465 1 0 0 1.4464454 0.9938131 STC1
774 regulation of insulin secretion involved in cellular response to glucose stimulus (GO:0061178) 1/33 0.5030465 1 0 0 1.4464454 0.9938131 ADRA2A
775 response to progesterone (GO:0032570) 1/33 0.5030465 1 0 0 1.4464454 0.9938131 THBS1
776 transferrin transport (GO:0033572) 1/33 0.5030465 1 0 0 1.4464454 0.9938131 REP15
777 regulation of protein binding (GO:0043393) 3/128 0.5041604 1 0 0 1.1187351 0.7661777 CSF3;NKX3-1;CTHRC1
778 response to mechanical stimulus (GO:0009612) 4/176 0.5053159 1 0 0 1.0848340 0.7404767 NTRK2;PCDH15;PTGS2;THBS1
779 secretion by cell (GO:0032940) 9/415 0.5053996 1 0 0 1.0351669 0.7064041 NTRK2;SLC17A9;ADORA3;DOC2B;SLC6A1;SYT8;THBS1;F5;STXBP5L
780 platelet degranulation (GO:0002576) 2/81 0.5085318 1 0 0 1.1785851 0.7969918 THBS1;F5
781 regulation of epithelial cell migration (GO:0010632) 3/129 0.5093659 1 0 0 1.1100627 0.7488358 STC1;PTGS2;THBS1
782 negative regulation of reproductive process (GO:2000242) 1/34 0.5134749 1 0 0 1.4039028 0.9357774 NKX3-1
783 response to cocaine (GO:0042220) 1/34 0.5134749 1 0 0 1.4039028 0.9357774 SLC6A1
784 regulation of cholesterol transport (GO:0032374) 1/34 0.5134749 1 0 0 1.4039028 0.9357774 LIPG
785 regulation of sterol transport (GO:0032371) 1/34 0.5134749 1 0 0 1.4039028 0.9357774 LIPG
786 negative regulation of tumor necrosis factor production (GO:0032720) 1/34 0.5134749 1 0 0 1.4039028 0.9357774 IRAK3
787 positive regulation of T cell mediated immunity (GO:0002711) 1/34 0.5134749 1 0 0 1.4039028 0.9357774 AZGP1
788 neuron fate commitment (GO:0048663) 1/34 0.5134749 1 0 0 1.4039028 0.9357774 PAX6
789 neuromuscular junction development (GO:0007528) 1/34 0.5134749 1 0 0 1.4039028 0.9357774 NTRK2
790 G2 DNA damage checkpoint (GO:0031572) 1/34 0.5134749 1 0 0 1.4039028 0.9357774 NEK6
791 regulation of dendritic spine development (GO:0060998) 1/34 0.5134749 1 0 0 1.4039028 0.9357774 CUX2
792 positive regulation of bone mineralization (GO:0030501) 1/34 0.5134749 1 0 0 1.4039028 0.9357774 FBN2
793 response to alcohol (GO:0097305) 6/274 0.5139041 1 0 0 1.0452415 0.6958368 STC1;TFF1;SLC6A1;PTGS2;THBS1;NKX3-1
794 regulation of system process (GO:0044057) 8/371 0.5170404 1 0 0 1.0292765 0.6789460 C1QTNF1;EDN2;ADORA3;STC1;TNNI3;PTGS2;ADRA2A;NKX3-1
795 cognition (GO:0050890) 5/227 0.5178823 1 0 0 1.0513810 0.6918163 NTRK2;CUX2;CHRM1;SLC6A1;PTGS2
796 regulation of angiogenesis (GO:0045765) 4/179 0.5185687 1 0 0 1.0666524 0.7004524 CCL24;ADM2;PTGS2;THBS1
797 positive regulation of intracellular protein transport (GO:0090316) 3/131 0.5196902 1 0 0 1.0931152 0.7154685 CSF3;CHRM1;PTGS2
798 response to lipopolysaccharide (GO:0032496) 5/228 0.5217758 1 0 0 1.0467697 0.6809418 CSF3;IRAK3;APOB;PTGS2;CYP17A1
799 ferric iron transport (GO:0015682) 1/35 0.5236849 1 0 0 1.3637913 0.8821891 REP15
800 drug metabolic process (GO:0017144) 1/35 0.5236849 1 0 0 1.3637913 0.8821891 CYP3A5
801 positive regulation of neural precursor cell proliferation (GO:2000179) 1/35 0.5236849 1 0 0 1.3637913 0.8821891 PAX6
802 metanephros development (GO:0001656) 1/35 0.5236849 1 0 0 1.3637913 0.8821891 NKX3-1
803 negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556) 1/35 0.5236849 1 0 0 1.3637913 0.8821891 IRAK3
804 negative regulation of ion transmembrane transporter activity (GO:0032413) 1/35 0.5236849 1 0 0 1.3637913 0.8821891 ADRA2A
805 positive regulation of phagocytosis (GO:0050766) 1/35 0.5236849 1 0 0 1.3637913 0.8821891 AHSG
806 positive regulation of alpha-beta T cell differentiation (GO:0046638) 1/35 0.5236849 1 0 0 1.3637913 0.8821891 ZBTB16
807 negative regulation of nucleoside metabolic process (GO:0045978) 1/35 0.5236849 1 0 0 1.3637913 0.8821891 TNNI3
808 glycoprotein biosynthetic process (GO:0009101) 1/35 0.5236849 1 0 0 1.3637913 0.8821891 B3GNT6
809 cAMP metabolic process (GO:0046058) 1/35 0.5236849 1 0 0 1.3637913 0.8821891 PTHLH
810 trivalent inorganic cation transport (GO:0072512) 1/35 0.5236849 1 0 0 1.3637913 0.8821891 REP15
811 hexose catabolic process (GO:0019320) 1/35 0.5236849 1 0 0 1.3637913 0.8821891 FUT6
812 protein trimerization (GO:0070206) 1/35 0.5236849 1 0 0 1.3637913 0.8821891 C1QTNF1
813 positive regulation of protein localization to nucleus (GO:1900182) 2/84 0.5280072 1 0 0 1.1364928 0.7258159 CSF3;PTGS2
814 chloride transmembrane transport (GO:1902476) 2/84 0.5280072 1 0 0 1.1364928 0.7258159 ANO1;ANO7
815 negative regulation of peptidase activity (GO:0010466) 5/230 0.5295221 1 0 0 1.0376673 0.6597285 SERPINB4;AHSG;HMSD;SSPO;THBS1
816 positive regulation of protein transport (GO:0051222) 5/231 0.5333744 1 0 0 1.0331753 0.6493833 CSF3;CHRM1;PTGS2;ALOX15B;STXBP5L
817 regulation of cell-substrate junction assembly (GO:0090109) 1/36 0.5336812 1 0 0 1.3259082 0.8326130 THBS1
818 detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580) 1/36 0.5336812 1 0 0 1.3259082 0.8326130 AZGP1
819 regulation of insulin receptor signaling pathway (GO:0046626) 1/36 0.5336812 1 0 0 1.3259082 0.8326130 AHSG
820 regulation of histone acetylation (GO:0035065) 1/36 0.5336812 1 0 0 1.3259082 0.8326130 MUC1
821 regulation of focal adhesion assembly (GO:0051893) 1/36 0.5336812 1 0 0 1.3259082 0.8326130 THBS1
822 regulation of catecholamine secretion (GO:0050433) 1/36 0.5336812 1 0 0 1.3259082 0.8326130 ADRA2A
823 synaptic transmission, glutamatergic (GO:0035249) 1/36 0.5336812 1 0 0 1.3259082 0.8326130 PLAT
824 positive regulation of biomineral tissue development (GO:0070169) 1/36 0.5336812 1 0 0 1.3259082 0.8326130 FBN2
825 positive regulation of synaptic transmission (GO:0050806) 2/85 0.5343819 1 0 0 1.1231223 0.7037984 NTRK2;PTGS2
826 blood vessel development (GO:0001568) 2/85 0.5343819 1 0 0 1.1231223 0.7037984 PAX6;NKX3-1
827 regulation of striated muscle cell differentiation (GO:0051153) 2/85 0.5343819 1 0 0 1.1231223 0.7037984 CEACAM5;MYLK3
828 second-messenger-mediated signaling (GO:0019932) 3/134 0.5349533 1 0 0 1.0686425 0.6685170 NTRK2;EDN2;BHLHA15
829 positive regulation of cell migration (GO:0030335) 6/280 0.5350561 1 0 0 1.0228435 0.6396697 CCL24;EDN2;ADORA3;PTGS2;THBS1;ADRA2A
830 negative regulation of secretion by cell (GO:1903531) 3/135 0.5399797 1 0 0 1.0607266 0.6536449 BMP8A;ADRA2A;STXBP5L
831 regulation of reproductive process (GO:2000241) 2/86 0.5406975 1 0 0 1.1100627 0.6825724 PLAT;NKX3-1
832 embryonic limb morphogenesis (GO:0030326) 2/86 0.5406975 1 0 0 1.1100627 0.6825724 FBN2;ZBTB16
833 regulation of stem cell proliferation (GO:0072091) 2/86 0.5406975 1 0 0 1.1100627 0.6825724 SIX3;PAX6
834 long-chain fatty acid metabolic process (GO:0001676) 2/86 0.5406975 1 0 0 1.1100627 0.6825724 PTGS2;ALOX15B
835 vascular process in circulatory system (GO:0003018) 2/86 0.5406975 1 0 0 1.1100627 0.6825724 EDN2;MYLK3
836 embryonic appendage morphogenesis (GO:0035113) 2/86 0.5406975 1 0 0 1.1100627 0.6825724 FBN2;ZBTB16
837 exocytosis (GO:0006887) 5/233 0.5410362 1 0 0 1.0243068 0.6292000 SLC17A9;SYT8;THBS1;F5;STXBP5L
838 mitotic nuclear envelope disassembly (GO:0007077) 1/37 0.5434681 1 0 0 1.2900729 0.7866661 NEK6
839 regulation of epidermal cell differentiation (GO:0045604) 1/37 0.5434681 1 0 0 1.2900729 0.7866661 ALOX15B
840 positive regulation of leukocyte mediated cytotoxicity (GO:0001912) 1/37 0.5434681 1 0 0 1.2900729 0.7866661 AZGP1
841 regulation of toll-like receptor signaling pathway (GO:0034121) 1/37 0.5434681 1 0 0 1.2900729 0.7866661 IRAK3
842 regulation of adherens junction organization (GO:1903391) 1/37 0.5434681 1 0 0 1.2900729 0.7866661 THBS1
843 feeding behavior (GO:0007631) 2/87 0.5469535 1 0 0 1.0973034 0.6621035 NTRK2;ADM2
844 regulation of fat cell differentiation (GO:0045598) 2/87 0.5469535 1 0 0 1.0973034 0.6621035 ZBTB16;PTGS2
845 dicarboxylic acid metabolic process (GO:0043648) 2/87 0.5469535 1 0 0 1.0973034 0.6621035 ALDH1L2;CYP17A1
846 adult walking behavior (GO:0007628) 1/38 0.5530502 1 0 0 1.2561236 0.7440102 PCDH15
847 epithelial cell morphogenesis (GO:0003382) 1/38 0.5530502 1 0 0 1.2561236 0.7440102 STC1
848 muscle filament sliding (GO:0030049) 1/38 0.5530502 1 0 0 1.2561236 0.7440102 TNNI3
849 protein kinase C-activating G-protein coupled receptor signaling pathway (GO:0007205) 1/38 0.5530502 1 0 0 1.2561236 0.7440102 CHRM1
850 membrane depolarization during action potential (GO:0086010) 1/38 0.5530502 1 0 0 1.2561236 0.7440102 CACNA1E
851 hindlimb morphogenesis (GO:0035137) 1/38 0.5530502 1 0 0 1.2561236 0.7440102 ZBTB16
852 anion homeostasis (GO:0055081) 1/38 0.5530502 1 0 0 1.2561236 0.7440102 LIPG
853 regulation of calcium-mediated signaling (GO:0050848) 1/38 0.5530502 1 0 0 1.2561236 0.7440102 ADORA3
854 regulation of lipid storage (GO:0010883) 1/38 0.5530502 1 0 0 1.2561236 0.7440102 APOB
855 ventricular cardiac muscle tissue morphogenesis (GO:0055010) 1/38 0.5530502 1 0 0 1.2561236 0.7440102 TNNI3
856 positive regulation of oxidoreductase activity (GO:0051353) 1/38 0.5530502 1 0 0 1.2561236 0.7440102 EDN2
857 actin-myosin filament sliding (GO:0033275) 1/38 0.5530502 1 0 0 1.2561236 0.7440102 TNNI3
858 positive regulation of reactive oxygen species metabolic process (GO:2000379) 1/38 0.5530502 1 0 0 1.2561236 0.7440102 THBS1
859 regulation of endothelial cell proliferation (GO:0001936) 2/88 0.5531498 1 0 0 1.0848340 0.6423590 CCL24;THBS1
860 pattern specification process (GO:0007389) 8/385 0.5591631 1 0 0 0.9918482 0.5765754 LEFTY1;DAAM2;ZBTB16;SIX3;STC1;PAX6;FEZF1;NKX3-1
861 positive regulation of cell motility (GO:2000147) 6/287 0.5592308 1 0 0 0.9978961 0.5799703 CCL24;EDN2;ADORA3;PTGS2;THBS1;ADRA2A
862 cellular response to reactive oxygen species (GO:0034614) 2/89 0.5592860 1 0 0 1.0726449 0.6233079 TPO;PXDN
863 regulation of dendrite development (GO:0050773) 2/89 0.5592860 1 0 0 1.0726449 0.6233079 NTRK2;CUX2
864 heart morphogenesis (GO:0003007) 1/39 0.5624316 1 0 0 1.2239153 0.7043459 LEFTY1
865 regulation of multicellular organismal metabolic process (GO:0044246) 1/39 0.5624316 1 0 0 1.2239153 0.7043459 BMP8A
866 retina homeostasis (GO:0001895) 1/39 0.5624316 1 0 0 1.2239153 0.7043459 AZGP1
867 bile acid metabolic process (GO:0008206) 1/39 0.5624316 1 0 0 1.2239153 0.7043459 SLCO1B3
868 positive regulation of dendrite development (GO:1900006) 1/39 0.5624316 1 0 0 1.2239153 0.7043459 CUX2
869 endocrine pancreas development (GO:0031018) 1/39 0.5624316 1 0 0 1.2239153 0.7043459 FOXA3
870 positive regulation of striated muscle cell differentiation (GO:0051155) 1/39 0.5624316 1 0 0 1.2239153 0.7043459 MYLK3
871 phagosome maturation (GO:0090382) 1/39 0.5624316 1 0 0 1.2239153 0.7043459 RAB43
872 membrane disassembly (GO:0030397) 1/39 0.5624316 1 0 0 1.2239153 0.7043459 NEK6
873 hippocampus development (GO:0021766) 1/39 0.5624316 1 0 0 1.2239153 0.7043459 CYP17A1
874 regulation of NF-kappaB import into nucleus (GO:0042345) 1/39 0.5624316 1 0 0 1.2239153 0.7043459 PTGS2
875 detection of mechanical stimulus (GO:0050982) 1/39 0.5624316 1 0 0 1.2239153 0.7043459 PCDH15
876 acute-phase response (GO:0006953) 1/39 0.5624316 1 0 0 1.2239153 0.7043459 AHSG
877 nuclear envelope disassembly (GO:0051081) 1/39 0.5624316 1 0 0 1.2239153 0.7043459 NEK6
878 bone mineralization (GO:0030282) 1/39 0.5624316 1 0 0 1.2239153 0.7043459 PTGS2
879 negative regulation of blood pressure (GO:0045776) 1/39 0.5624316 1 0 0 1.2239153 0.7043459 ADM2
880 regulation of vasodilation (GO:0042312) 1/39 0.5624316 1 0 0 1.2239153 0.7043459 ADRA2A
881 spindle assembly (GO:0051225) 1/39 0.5624316 1 0 0 1.2239153 0.7043459 NEK6
882 neurogenesis (GO:0022008) 1/39 0.5624316 1 0 0 1.2239153 0.7043459 OMP
883 regulation of heart contraction (GO:0008016) 3/140 0.5646363 1 0 0 1.0228435 0.5846303 EDN2;ADORA3;STC1
884 positive regulation of chemotaxis (GO:0050921) 2/90 0.5653620 1 0 0 1.0607266 0.6049208 EDN2;THBS1
885 regulation of neurotransmitter levels (GO:0001505) 2/90 0.5653620 1 0 0 1.0607266 0.6049208 DOC2B;SLC6A1
886 positive regulation of calcium ion transport (GO:0051928) 2/91 0.5713775 1 0 0 1.0490703 0.5871700 JPH2;STC1
887 regulation of peptidyl-lysine acetylation (GO:2000756) 1/40 0.5716165 1 0 0 1.1933174 0.6674069 MUC1
888 monosaccharide catabolic process (GO:0046365) 1/40 0.5716165 1 0 0 1.1933174 0.6674069 FUT6
889 forelimb morphogenesis (GO:0035136) 1/40 0.5716165 1 0 0 1.1933174 0.6674069 ZBTB16
890 blood circulation (GO:0008015) 1/40 0.5716165 1 0 0 1.1933174 0.6674069 F5
891 outflow tract morphogenesis (GO:0003151) 1/40 0.5716165 1 0 0 1.1933174 0.6674069 THBS1
892 glutamate receptor signaling pathway (GO:0007215) 1/40 0.5716165 1 0 0 1.1933174 0.6674069 GRM8
893 response to nutrient levels (GO:0031667) 6/291 0.5727788 1 0 0 0.9841793 0.5484395 HSD11B2;LIPG;STC1;PTGS2;FOXA3;CYP17A1
894 chloride transport (GO:0006821) 2/92 0.5773325 1 0 0 1.0376673 0.5700289 ANO1;ANO7
895 negative regulation of cell-cell adhesion (GO:0022408) 1/41 0.5806091 1 0 0 1.1642121 0.6329560 C1QTNF1
896 regulation of transcription from RNA polymerase II promoter in response to stress (GO:0043618) 1/41 0.5806091 1 0 0 1.1642121 0.6329560 MUC1
897 positive regulation of chemokine production (GO:0032722) 1/41 0.5806091 1 0 0 1.1642121 0.6329560 ALOX15B
898 cardiac muscle contraction (GO:0060048) 1/41 0.5806091 1 0 0 1.1642121 0.6329560 TNNI3
899 regulation of alcohol biosynthetic process (GO:1902930) 1/41 0.5806091 1 0 0 1.1642121 0.6329560 APOB
900 somitogenesis (GO:0001756) 1/41 0.5806091 1 0 0 1.1642121 0.6329560 NKX3-1
901 protein peptidyl-prolyl isomerization (GO:0000413) 1/41 0.5806091 1 0 0 1.1642121 0.6329560 FKBP5
902 response to exogenous dsRNA (GO:0043330) 1/41 0.5806091 1 0 0 1.1642121 0.6329560 IRAK3
903 regulation of synapse assembly (GO:0051963) 1/41 0.5806091 1 0 0 1.1642121 0.6329560 CUX2
904 negative regulation of muscle cell differentiation (GO:0051148) 1/41 0.5806091 1 0 0 1.1642121 0.6329560 CEACAM5
905 positive regulation of binding (GO:0051099) 2/93 0.5832269 1 0 0 1.0265096 0.5534724 CSF3;CTHRC1
906 regulation of synaptic transmission (GO:0050804) 5/245 0.5857120 1 0 0 0.9741367 0.5210921 NTRK2;GRM8;PLAT;SLC6A1;PTGS2
907 visual perception (GO:0007601) 4/195 0.5862086 1 0 0 0.9791322 0.5229346 GRM8;SIX3;PCDH15;PAX6
908 positive regulation of nucleocytoplasmic transport (GO:0046824) 2/94 0.5890605 1 0 0 1.0155893 0.5374767 CSF3;PTGS2
909 negative regulation of cell-substrate adhesion (GO:0010812) 1/42 0.5894134 1 0 0 1.1364928 0.6007814 THBS1
910 regulation of ATPase activity (GO:0043462) 1/42 0.5894134 1 0 0 1.1364928 0.6007814 TNNI3
911 calcium ion transport into cytosol (GO:0060402) 1/42 0.5894134 1 0 0 1.1364928 0.6007814 JPH2
912 positive regulation of cell killing (GO:0031343) 1/42 0.5894134 1 0 0 1.1364928 0.6007814 AZGP1
913 negative regulation of response to DNA damage stimulus (GO:2001021) 1/42 0.5894134 1 0 0 1.1364928 0.6007814 MUC1
914 regulation of ATP catabolic process (GO:1903289) 1/42 0.5894134 1 0 0 1.1364928 0.6007814 TNNI3
915 regulation of alpha-beta T cell differentiation (GO:0046637) 1/42 0.5894134 1 0 0 1.1364928 0.6007814 ZBTB16
916 regulation of protein acetylation (GO:1901983) 1/42 0.5894134 1 0 0 1.1364928 0.6007814 MUC1
917 androgen receptor signaling pathway (GO:0030521) 1/42 0.5894134 1 0 0 1.1364928 0.6007814 NKX3-1
918 positive regulation of cellular component movement (GO:0051272) 6/296 0.5894219 1 0 0 0.9675547 0.5114620 CCL24;EDN2;ADORA3;PTGS2;THBS1;ADRA2A
919 regionalization (GO:0003002) 5/247 0.5929271 1 0 0 0.9662489 0.5050426 ZBTB16;SIX3;PAX6;FEZF1;NKX3-1
920 regulation of vasculature development (GO:1901342) 4/197 0.5942693 1 0 0 0.9691918 0.5043894 CCL24;ADM2;PTGS2;THBS1
921 response to hydrogen peroxide (GO:0042542) 2/95 0.5948333 1 0 0 1.0048989 0.5220190 TPO;PXDN
922 hemopoiesis (GO:0030097) 2/95 0.5948333 1 0 0 1.0048989 0.5220190 TPO;ZBTB16
923 regulation of cytokine-mediated signaling pathway (GO:0001959) 2/95 0.5948333 1 0 0 1.0048989 0.5220190 PXDN;IRAK3
924 cellular response to acid chemical (GO:0071229) 3/147 0.5977683 1 0 0 0.9741367 0.5012440 MUC1;BRINP1;APOB
925 detection of chemical stimulus involved in sensory perception of taste (GO:0050912) 1/43 0.5980332 1 0 0 1.1100627 0.5706932 AZGP1
926 cerebral cortex development (GO:0021987) 1/43 0.5980332 1 0 0 1.1100627 0.5706932 NTRK2
927 cellular response to cAMP (GO:0071320) 1/43 0.5980332 1 0 0 1.1100627 0.5706932 STC1
928 catecholamine metabolic process (GO:0006584) 1/43 0.5980332 1 0 0 1.1100627 0.5706932 GPR37
929 cytosolic calcium ion transport (GO:0060401) 1/43 0.5980332 1 0 0 1.1100627 0.5706932 JPH2
930 negative regulation of transporter activity (GO:0032410) 1/43 0.5980332 1 0 0 1.1100627 0.5706932 ADRA2A
931 catechol-containing compound metabolic process (GO:0009712) 1/43 0.5980332 1 0 0 1.1100627 0.5706932 GPR37
932 regulation of cardiac muscle contraction (GO:0055117) 1/43 0.5980332 1 0 0 1.1100627 0.5706932 STC1
933 sperm motility (GO:0030317) 1/43 0.5980332 1 0 0 1.1100627 0.5706932 APOB
934 learning or memory (GO:0007611) 4/198 0.5982647 1 0 0 0.9642969 0.4953806 NTRK2;CUX2;SLC6A1;PTGS2
935 sensory perception of light stimulus (GO:0050953) 4/198 0.5982647 1 0 0 0.9642969 0.4953806 GRM8;SIX3;PCDH15;PAX6
936 positive regulation of cellular component biogenesis (GO:0044089) 5/249 0.6000726 1 0 0 0.9584879 0.4895042 CCL24;CSF3;CUX2;CDC42EP5;MYLK3
937 lipid homeostasis (GO:0055088) 2/96 0.6005453 1 0 0 0.9944312 0.5070776 LIPG;APOB
938 regulation of metal ion transport (GO:0010959) 5/250 0.6036188 1 0 0 0.9546539 0.4819212 JPH2;STC1;KCNN2;PTGS2;ADRA2A
939 negative regulation of extrinsic apoptotic signaling pathway (GO:2001237) 2/97 0.6061965 1 0 0 0.9841793 0.4926321 IL19;THBS1
940 glycolytic process (GO:0006096) 1/44 0.6064726 1 0 0 1.0848340 0.5425209 HKDC1
941 regulation of mitotic metaphase/anaphase transition (GO:0030071) 1/44 0.6064726 1 0 0 1.0848340 0.5425209 NEK6
942 regulation of lipid catabolic process (GO:0050994) 1/44 0.6064726 1 0 0 1.0848340 0.5425209 ADRA2A
943 positive regulation of tumor necrosis factor production (GO:0032760) 1/44 0.6064726 1 0 0 1.0848340 0.5425209 THBS1
944 lipoprotein metabolic process (GO:0042157) 1/44 0.6064726 1 0 0 1.0848340 0.5425209 APOB
945 regulation of signal transduction by p53 class mediator (GO:1901796) 1/44 0.6064726 1 0 0 1.0848340 0.5425209 MUC1
946 regulation of nitric oxide biosynthetic process (GO:0045428) 1/44 0.6064726 1 0 0 1.0848340 0.5425209 PTGS2
947 regulation of leukocyte mediated cytotoxicity (GO:0001910) 1/44 0.6064726 1 0 0 1.0848340 0.5425209 AZGP1
948 segmentation (GO:0035282) 1/44 0.6064726 1 0 0 1.0848340 0.5425209 NKX3-1
949 cell fate determination (GO:0001709) 1/44 0.6064726 1 0 0 1.0848340 0.5425209 PAX6
950 protein transmembrane transport (GO:0071806) 1/44 0.6064726 1 0 0 1.0848340 0.5425209 AZGP1
951 multicellular organismal homeostasis (GO:0048871) 1/44 0.6064726 1 0 0 1.0848340 0.5425209 EDN2
952 neutrophil chemotaxis (GO:0030593) 1/44 0.6064726 1 0 0 1.0848340 0.5425209 EDN2
953 negative regulation of proteolysis (GO:0045861) 6/302 0.6089415 1 0 0 0.9483317 0.4704039 SERPINB4;AHSG;HMSD;SSPO;PLAT;THBS1
954 protein processing (GO:0016485) 4/201 0.6101088 1 0 0 0.9499044 0.4693648 CPE;PLAT;PTHLH;NKX3-1
955 actin filament bundle assembly (GO:0051017) 1/45 0.6147351 1 0 0 1.0607266 0.5161112 SHROOM1
956 eye morphogenesis (GO:0048592) 1/45 0.6147351 1 0 0 1.0607266 0.5161112 PAX6
957 regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902041) 1/45 0.6147351 1 0 0 1.0607266 0.5161112 THBS1
958 regulation of metaphase/anaphase transition of cell cycle (GO:1902099) 1/45 0.6147351 1 0 0 1.0607266 0.5161112 NEK6
959 response to antibiotic (GO:0046677) 1/45 0.6147351 1 0 0 1.0607266 0.5161112 CYP17A1
960 positive regulation of ion transmembrane transporter activity (GO:0032414) 1/45 0.6147351 1 0 0 1.0607266 0.5161112 JPH2
961 neutrophil migration (GO:1990266) 1/45 0.6147351 1 0 0 1.0607266 0.5161112 EDN2
962 regulation of cellular response to insulin stimulus (GO:1900076) 1/45 0.6147351 1 0 0 1.0607266 0.5161112 AHSG
963 actin filament bundle organization (GO:0061572) 1/45 0.6147351 1 0 0 1.0607266 0.5161112 SHROOM1
964 positive regulation of locomotion (GO:0040017) 6/304 0.6153339 1 0 0 0.9420927 0.4574711 CCL24;EDN2;ADORA3;PTGS2;THBS1;ADRA2A
965 neurotransmitter transport (GO:0006836) 2/99 0.6173166 1 0 0 0.9642969 0.4651511 DOC2B;SLC6A1
966 positive regulation of cytosolic calcium ion concentration (GO:0007204) 3/152 0.6204039 1 0 0 0.9420927 0.4497405 JPH2;C1QTNF1;EDN2
967 negative regulation of secretion (GO:0051048) 3/152 0.6204039 1 0 0 0.9420927 0.4497405 BMP8A;ADRA2A;STXBP5L
968 cell morphogenesis (GO:0000902) 4/204 0.6217366 1 0 0 0.9359352 0.4447927 STC1;TFCP2L1;SHROOM1;WNT16
969 cell-matrix adhesion (GO:0007160) 2/100 0.6227857 1 0 0 0.9546539 0.4520791 ITGA10;NID2
970 sensory perception of chemical stimulus (GO:0007606) 2/100 0.6227857 1 0 0 0.9546539 0.4520791 OMP;GRM8
971 response to calcium ion (GO:0051592) 2/100 0.6227857 1 0 0 0.9546539 0.4520791 SLC6A1;THBS1
972 leukocyte chemotaxis (GO:0030595) 2/100 0.6227857 1 0 0 0.9546539 0.4520791 CCL24;EDN2
973 fertilization (GO:0009566) 2/100 0.6227857 1 0 0 0.9546539 0.4520791 CATSPERB;APOB
974 regulation of T cell mediated immunity (GO:0002709) 1/46 0.6228246 1 0 0 1.0376673 0.4913255 AZGP1
975 regulation of DNA-templated transcription in response to stress (GO:0043620) 1/46 0.6228246 1 0 0 1.0376673 0.4913255 MUC1
976 positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557) 1/46 0.6228246 1 0 0 1.0376673 0.4913255 THBS1
977 actin-mediated cell contraction (GO:0070252) 1/46 0.6228246 1 0 0 1.0376673 0.4913255 TNNI3
978 artery morphogenesis (GO:0048844) 1/46 0.6228246 1 0 0 1.0376673 0.4913255 APOB
979 positive regulation of smooth muscle cell proliferation (GO:0048661) 1/46 0.6228246 1 0 0 1.0376673 0.4913255 PTGS2
980 positive regulation of Rac GTPase activity (GO:0032855) 1/46 0.6228246 1 0 0 1.0376673 0.4913255 CCL24
981 platelet activation (GO:0030168) 4/205 0.6255638 1 0 0 0.9313697 0.4369073 ENTPD2;THBS1;ADRA2A;F5
982 regulation of actin filament-based process (GO:0032970) 5/257 0.6279339 1 0 0 0.9286517 0.4321205 CCL24;CSF3;CDC42EP5;STC1;MYLK3
983 transition metal ion transport (GO:0000041) 2/101 0.6281942 1 0 0 0.9452019 0.4394299 TCN1;REP15
984 regulation of response to cytokine stimulus (GO:0060759) 2/101 0.6281942 1 0 0 0.9452019 0.4394299 PXDN;IRAK3
985 limb morphogenesis (GO:0035108) 2/101 0.6281942 1 0 0 0.9452019 0.4394299 FBN2;ZBTB16
986 appendage morphogenesis (GO:0035107) 2/101 0.6281942 1 0 0 0.9452019 0.4394299 FBN2;ZBTB16
987 extracellular matrix organization (GO:0030198) 7/359 0.6287802 1 0 0 0.9307211 0.4318299 COMP;FBN2;ITGA10;PXDN;NID2;THBS1;MUC5AC
988 developmental maturation (GO:0021700) 3/154 0.6292124 1 0 0 0.9298577 0.4307904 SIX3;BHLHA15;TFCP2L1
989 chaperone-mediated protein folding (GO:0061077) 1/47 0.6307446 1 0 0 1.0155893 0.4680387 FKBP5
990 neural precursor cell proliferation (GO:0061351) 1/47 0.6307446 1 0 0 1.0155893 0.4680387 SIX3
991 smooth muscle contraction (GO:0006939) 1/47 0.6307446 1 0 0 1.0155893 0.4680387 EDN2
992 cellular response to UV (GO:0034644) 1/47 0.6307446 1 0 0 1.0155893 0.4680387 PTGS2
993 acid secretion (GO:0046717) 1/47 0.6307446 1 0 0 1.0155893 0.4680387 NTRK2
994 extracellular structure organization (GO:0043062) 7/360 0.6316703 1 0 0 0.9281358 0.4263742 COMP;FBN2;ITGA10;PXDN;NID2;THBS1;MUC5AC
995 organic hydroxy compound transport (GO:0015850) 2/102 0.6335424 1 0 0 0.9359352 0.4271873 LIPG;APOB
996 zymogen activation (GO:0031638) 2/102 0.6335424 1 0 0 0.9359352 0.4271873 PLAT;NKX3-1
997 cell chemotaxis (GO:0060326) 3/155 0.6335636 1 0 0 0.9238586 0.4216444 CCL24;EDN2;CXCL2
998 anatomical structure homeostasis (GO:0060249) 4/208 0.6368974 1 0 0 0.9179365 0.4141241 AZGP1;TFF1;PTHLH;MUC6
999 regulation of cardiac muscle tissue development (GO:0055024) 1/48 0.6384987 1 0 0 0.9944312 0.4461373 JPH2
1000 sperm-egg recognition (GO:0035036) 1/48 0.6384987 1 0 0 0.9944312 0.4461373 CATSPERB
1001 positive regulation of alpha-beta T cell activation (GO:0046635) 1/48 0.6384987 1 0 0 0.9944312 0.4461373 ZBTB16
1002 phospholipid transport (GO:0015914) 1/48 0.6384987 1 0 0 0.9944312 0.4461373 ATP10B
1003 phagocytosis (GO:0006909) 1/48 0.6384987 1 0 0 0.9944312 0.4461373 ELMOD1
1004 regulation of transforming growth factor beta receptor signaling pathway (GO:0017015) 2/103 0.6388304 1 0 0 0.9268485 0.4153359 FBN2;THBS1
1005 sensory organ development (GO:0007423) 2/103 0.6388304 1 0 0 0.9268485 0.4153359 SIX3;PAX6
1006 positive regulation of lipid metabolic process (GO:0045834) 2/103 0.6388304 1 0 0 0.9268485 0.4153359 PTGS2;CYP17A1
1007 cellular calcium ion homeostasis (GO:0006874) 5/261 0.6414181 1 0 0 0.9144195 0.4060697 JPH2;C1QTNF1;EDN2;STC1;TNNI3
1008 response to extracellular stimulus (GO:0009991) 6/313 0.6433621 1 0 0 0.9150038 0.4035602 HSD11B2;LIPG;STC1;PTGS2;FOXA3;CYP17A1
1009 monocarboxylic acid transport (GO:0015718) 2/104 0.6440582 1 0 0 0.9179365 0.4038609 SLCO1B3;SLC6A1
1010 negative regulation of cellular response to growth factor stimulus (GO:0090288) 2/104 0.6440582 1 0 0 0.9179365 0.4038609 FBN2;THBS1
1011 cellular response to drug (GO:0035690) 1/49 0.6460903 1 0 0 0.9741367 0.4255184 NKX3-1
1012 regulation of cytokine production involved in immune response (GO:0002718) 1/49 0.6460903 1 0 0 0.9741367 0.4255184 IRAK3
1013 response to dsRNA (GO:0043331) 1/49 0.6460903 1 0 0 0.9741367 0.4255184 IRAK3
1014 regulation of ion transmembrane transport (GO:0034765) 6/314 0.6463999 1 0 0 0.9120897 0.3979785 JPH2;STC1;KCNN2;CACNA1E;THBS1;ADRA2A
1015 hormone metabolic process (GO:0042445) 3/158 0.6464036 1 0 0 0.9063170 0.3954544 TPO;CPE;CYP17A1
1016 response to ketone (GO:1901654) 2/105 0.6492262 1 0 0 0.9091942 0.3927483 THBS1;NKX3-1
1017 negative regulation of protein processing (GO:0010955) 6/316 0.6524286 1 0 0 0.9063170 0.3870459 SERPINB4;AHSG;HMSD;SSPO;PLAT;THBS1
1018 negative regulation of protein maturation (GO:1903318) 6/316 0.6524286 1 0 0 0.9063170 0.3870459 SERPINB4;AHSG;HMSD;SSPO;PLAT;THBS1
1019 cardiac muscle tissue morphogenesis (GO:0055008) 1/50 0.6535229 1 0 0 0.9546539 0.4060885 TNNI3
1020 epithelial to mesenchymal transition (GO:0001837) 1/50 0.6535229 1 0 0 0.9546539 0.4060885 WNT16
1021 sensory perception of pain (GO:0019233) 1/50 0.6535229 1 0 0 0.9546539 0.4060885 PTGS2
1022 negative regulation of protein binding (GO:0032091) 1/50 0.6535229 1 0 0 0.9546539 0.4060885 NKX3-1
1023 regulation of cell killing (GO:0031341) 1/50 0.6535229 1 0 0 0.9546539 0.4060885 AZGP1
1024 regulation of cell junction assembly (GO:1901888) 1/50 0.6535229 1 0 0 0.9546539 0.4060885 THBS1
1025 regulation of osteoblast differentiation (GO:0045667) 2/106 0.6543346 1 0 0 0.9006169 0.3819845 FBN2;CTHRC1
1026 membrane depolarization (GO:0051899) 2/106 0.6543346 1 0 0 0.9006169 0.3819845 CUX2;CACNA1E
1027 positive regulation of protein secretion (GO:0050714) 2/106 0.6543346 1 0 0 0.9006169 0.3819845 ALOX15B;STXBP5L
1028 epithelial cell development (GO:0002064) 2/107 0.6593834 1 0 0 0.8921999 0.3715567 PAX6;SPDEF
1029 positive regulation of behavior (GO:0048520) 2/107 0.6593834 1 0 0 0.8921999 0.3715567 EDN2;THBS1
1030 response to inorganic substance (GO:0010035) 7/370 0.6598612 1 0 0 0.9030510 0.3754215 TPO;PXDN;TFF1;APOB;SLC6A1;PTGS2;THBS1
1031 positive regulation of insulin secretion (GO:0032024) 1/51 0.6607998 1 0 0 0.9359352 0.3877621 DOC2B
1032 regulation of neurotransmitter secretion (GO:0046928) 1/51 0.6607998 1 0 0 0.9359352 0.3877621 NTRK2
1033 positive regulation of axonogenesis (GO:0050772) 1/51 0.6607998 1 0 0 0.9359352 0.3877621 NTRK2
1034 response to nutrient (GO:0007584) 3/163 0.6670891 1 0 0 0.8785159 0.3556511 LIPG;STC1;PTGS2
1035 demethylation (GO:0070988) 1/52 0.6679242 1 0 0 0.9179365 0.3704614 CYP3A5
1036 positive regulation of transporter activity (GO:0032411) 1/52 0.6679242 1 0 0 0.9179365 0.3704614 JPH2
1037 regulation of excitatory postsynaptic membrane potential (GO:0060079) 1/52 0.6679242 1 0 0 0.9179365 0.3704614 CUX2
1038 regulation of phagocytosis (GO:0050764) 1/52 0.6679242 1 0 0 0.9179365 0.3704614 AHSG
1039 nuclear envelope organization (GO:0006998) 1/52 0.6679242 1 0 0 0.9179365 0.3704614 NEK6
1040 regulation of epithelial cell differentiation (GO:0030856) 2/109 0.6693038 1 0 0 0.8758293 0.3516605 PAX6;ALOX15B
1041 positive regulation of intracellular transport (GO:0032388) 4/217 0.6695431 1 0 0 0.8798654 0.3529666 CSF3;CHRM1;ADORA3;PTGS2
1042 positive regulation of neuron differentiation (GO:0045666) 4/217 0.6695431 1 0 0 0.8798654 0.3529666 NTRK2;CUX2;BRINP1;FEZF1
1043 cellular divalent inorganic cation homeostasis (GO:0072503) 5/271 0.6737754 1 0 0 0.8806771 0.3477428 JPH2;C1QTNF1;EDN2;STC1;TNNI3
1044 cellular response to lipopolysaccharide (GO:0071222) 2/110 0.6741759 1 0 0 0.8678672 0.3421690 CSF3;CYP17A1
1045 regulation of protein tyrosine kinase activity (GO:0061097) 1/53 0.6748993 1 0 0 0.9006169 0.3541152 ADRA2A
1046 regulation of epidermis development (GO:0045682) 1/53 0.6748993 1 0 0 0.9006169 0.3541152 ALOX15B
1047 regulation of cellular component size (GO:0032535) 3/165 0.6751126 1 0 0 0.8678672 0.3409640 CCL24;CSF3;CDC42EP5
1048 inflammatory response (GO:0006954) 7/376 0.6761377 1 0 0 0.8886406 0.3477771 CCL24;AHSG;ADORA3;PTGS2;CXCL2;THBS1;ADRA2A
1049 response to hexose (GO:0009746) 2/111 0.6789896 1 0 0 0.8600486 0.3329674 PTGS2;THBS1
1050 response to estrogen (GO:0043627) 3/166 0.6790707 1 0 0 0.8626391 0.3338672 TFF1;SLC6A1;PTGS2
1051 negative regulation of cell migration (GO:0030336) 3/166 0.6790707 1 0 0 0.8626391 0.3338672 STC1;ALOX15B;THBS1
1052 regulation of striated muscle contraction (GO:0006942) 1/54 0.6817282 1 0 0 0.8839388 0.3386584 STC1
1053 monocarboxylic acid biosynthetic process (GO:0072330) 3/167 0.6829931 1 0 0 0.8574736 0.3269295 EDN2;PTGS2;ALOX15B
1054 response to wounding (GO:0009611) 3/167 0.6829931 1 0 0 0.8574736 0.3269295 ADORA3;PLAT;PAX6
1055 calcium ion homeostasis (GO:0055074) 5/274 0.6830977 1 0 0 0.8710346 0.3319664 JPH2;C1QTNF1;EDN2;STC1;TNNI3
1056 regulation of cell shape (GO:0008360) 2/112 0.6837452 1 0 0 0.8523696 0.3240453 CCL24;CDC42EP5
1057 regulation of transmembrane transport (GO:0034762) 6/327 0.6844458 1 0 0 0.8758293 0.3320670 JPH2;STC1;KCNN2;CACNA1E;THBS1;ADRA2A
1058 response to acid chemical (GO:0001101) 5/275 0.6861652 1 0 0 0.8678672 0.3268708 MUC1;BRINP1;APOB;PTGS2;CYP17A1
1059 negative regulation of endopeptidase activity (GO:0010951) 4/222 0.6867877 1 0 0 0.8600486 0.3231461 SERPINB4;AHSG;HMSD;THBS1
1060 protein maturation (GO:0051604) 4/222 0.6867877 1 0 0 0.8600486 0.3231461 CPE;PLAT;PTHLH;NKX3-1
1061 positive regulation of apoptotic signaling pathway (GO:2001235) 3/168 0.6868797 1 0 0 0.8523696 0.3201467 IL19;THBS1;NKX3-1
1062 peptidyl-proline modification (GO:0018208) 1/55 0.6884140 1 0 0 0.8678672 0.3240311 FKBP5
1063 positive regulation of histone modification (GO:0031058) 1/55 0.6884140 1 0 0 0.8678672 0.3240311 MUC1
1064 embryonic digit morphogenesis (GO:0042733) 1/55 0.6884140 1 0 0 0.8678672 0.3240311 ZBTB16
1065 mesenchyme development (GO:0060485) 1/55 0.6884140 1 0 0 0.8678672 0.3240311 THBS1
1066 JNK cascade (GO:0007254) 1/55 0.6884140 1 0 0 0.8678672 0.3240311 CDC42EP5
1067 DNA duplex unwinding (GO:0032508) 1/55 0.6884140 1 0 0 0.8678672 0.3240311 RTEL1-TNFRSF6B
1068 single-organism carbohydrate catabolic process (GO:0044724) 2/113 0.6884430 1 0 0 0.8448265 0.3153930 FUT6;HKDC1
1069 carboxylic acid transport (GO:0046942) 4/224 0.6935057 1 0 0 0.8523696 0.3119638 NTRK2;SLCO1B3;SLC6A1;SLC13A5
1070 negative regulation of cell motility (GO:2000146) 3/170 0.6945459 1 0 0 0.8423417 0.3070311 STC1;ALOX15B;THBS1
1071 protein autophosphorylation (GO:0046777) 3/170 0.6945459 1 0 0 0.8423417 0.3070311 NTRK2;NEK6;IRAK3
1072 regulation of dendrite morphogenesis (GO:0048814) 1/56 0.6949597 1 0 0 0.8523696 0.3101785 CUX2
1073 positive regulation of chromatin modification (GO:1903310) 1/56 0.6949597 1 0 0 0.8523696 0.3101785 MUC1
1074 iron ion transport (GO:0006826) 1/56 0.6949597 1 0 0 0.8523696 0.3101785 REP15
1075 regulation of chemokine production (GO:0032642) 1/56 0.6949597 1 0 0 0.8523696 0.3101785 ALOX15B
1076 muscle tissue morphogenesis (GO:0060415) 1/56 0.6949597 1 0 0 0.8523696 0.3101785 TNNI3
1077 negative regulation of protein complex disassembly (GO:0043242) 1/56 0.6949597 1 0 0 0.8523696 0.3101785 IRAK3
1078 organic acid transport (GO:0015849) 4/226 0.7001206 1 0 0 0.8448265 0.3011829 NTRK2;SLCO1B3;SLC6A1;SLC13A5
1079 DNA geometric change (GO:0032392) 1/57 0.7013682 1 0 0 0.8374157 0.2970500 RTEL1-TNFRSF6B
1080 positive regulation of response to DNA damage stimulus (GO:2001022) 1/57 0.7013682 1 0 0 0.8374157 0.2970500 NKX3-1
1081 positive regulation of extrinsic apoptotic signaling pathway (GO:2001238) 1/57 0.7013682 1 0 0 0.8374157 0.2970500 THBS1
1082 homotypic cell-cell adhesion (GO:0034109) 1/57 0.7013682 1 0 0 0.8374157 0.2970500 CEACAM5
1083 actomyosin structure organization (GO:0031032) 1/57 0.7013682 1 0 0 0.8374157 0.2970500 MYLK3
1084 cell-cell recognition (GO:0009988) 1/57 0.7013682 1 0 0 0.8374157 0.2970500 CATSPERB
1085 regulation of myotube differentiation (GO:0010830) 1/57 0.7013682 1 0 0 0.8374157 0.2970500 CEACAM5
1086 response to monosaccharide (GO:0034284) 2/116 0.7021932 1 0 0 0.8229775 0.2909610 PTGS2;THBS1
1087 cellular response to molecule of bacterial origin (GO:0071219) 2/116 0.7021932 1 0 0 0.8229775 0.2909610 CSF3;CYP17A1
1088 embryonic pattern specification (GO:0009880) 1/58 0.7076424 1 0 0 0.8229775 0.2845991 ZBTB16
1089 regulation of postsynaptic membrane potential (GO:0060078) 1/58 0.7076424 1 0 0 0.8229775 0.2845991 CUX2
1090 neuron-neuron synaptic transmission (GO:0007270) 1/58 0.7076424 1 0 0 0.8229775 0.2845991 PLAT
1091 cyclic nucleotide metabolic process (GO:0009187) 1/58 0.7076424 1 0 0 0.8229775 0.2845991 PTHLH
1092 retina development in camera-type eye (GO:0060041) 1/58 0.7076424 1 0 0 0.8229775 0.2845991 PAX6
1093 regulation of hormone levels (GO:0010817) 4/229 0.7098499 1 0 0 0.8337589 0.2857306 TPO;ADORA3;CPE;CYP17A1
1094 positive regulation of neurogenesis (GO:0050769) 5/283 0.7099804 1 0 0 0.8433339 0.2888570 NTRK2;CUX2;BRINP1;PAX6;FEZF1
1095 anion transport (GO:0006820) 8/443 0.7134001 1 0 0 0.8619900 0.2911051 NTRK2;ANO1;SLC26A2;SLCO1B3;ATP10B;ANO7;SLC6A1;SLC13A5
1096 cellular ketone metabolic process (GO:0042180) 1/59 0.7137851 1 0 0 0.8090288 0.2727830 CYP17A1
1097 steroid hormone mediated signaling pathway (GO:0043401) 1/59 0.7137851 1 0 0 0.8090288 0.2727830 NKX3-1
1098 positive regulation of cytokine biosynthetic process (GO:0042108) 1/59 0.7137851 1 0 0 0.8090288 0.2727830 THBS1
1099 tetrapyrrole metabolic process (GO:0033013) 1/59 0.7137851 1 0 0 0.8090288 0.2727830 TCN1
1100 sterol metabolic process (GO:0016125) 2/119 0.7154359 1 0 0 0.8022302 0.2686374 APOB;CYP17A1
1101 cytosolic calcium ion homeostasis (GO:0051480) 3/176 0.7166933 1 0 0 0.8136255 0.2710246 JPH2;C1QTNF1;EDN2
1102 regulation of anatomical structure size (GO:0090066) 4/232 0.7193477 1 0 0 0.8229775 0.2710974 CCL24;CSF3;EDN2;CDC42EP5
1103 positive regulation of organelle organization (GO:0010638) 6/340 0.7197285 1 0 0 0.8423417 0.2770304 CCL24;CSF3;MUC1;CDC42EP5;DOC2B;MYLK3
1104 regulation of leukocyte mediated immunity (GO:0002703) 2/120 0.7197391 1 0 0 0.7955449 0.2616281 AZGP1;ADORA3
1105 epidermis development (GO:0008544) 2/120 0.7197391 1 0 0 0.7955449 0.2616281 CDSN;PTHLH
1106 regulation of chemotaxis (GO:0050920) 2/120 0.7197391 1 0 0 0.7955449 0.2616281 EDN2;THBS1
1107 carbohydrate catabolic process (GO:0016052) 2/120 0.7197391 1 0 0 0.7955449 0.2616281 FUT6;HKDC1
1108 single fertilization (GO:0007338) 1/60 0.7197990 1 0 0 0.7955449 0.2615619 CATSPERB
1109 neuron development (GO:0048666) 2/121 0.7239875 1 0 0 0.7889702 0.2548225 NTRK2;PAX6
1110 actin filament-based movement (GO:0030048) 1/61 0.7256868 1 0 0 0.7825032 0.2508993 TNNI3
1111 cell fate specification (GO:0001708) 1/61 0.7256868 1 0 0 0.7825032 0.2508993 PAX6
1112 secretion by tissue (GO:0032941) 1/61 0.7256868 1 0 0 0.7825032 0.2508993 CHRM1
1113 kidney development (GO:0001822) 2/122 0.7281814 1 0 0 0.7825032 0.2482140 ZBTB16;NKX3-1
1114 response to oxidative stress (GO:0006979) 5/290 0.7297575 1 0 0 0.8229775 0.2592733 TPO;PXDN;PYCR1;PTGS2;WNT16
1115 cell aging (GO:0007569) 1/62 0.7314513 1 0 0 0.7698822 0.2407612 WNT16
1116 negative regulation of G-protein coupled receptor protein signaling pathway (GO:0045744) 1/62 0.7314513 1 0 0 0.7698822 0.2407612 ADRA2A
1117 stem cell differentiation (GO:0048863) 1/62 0.7314513 1 0 0 0.7698822 0.2407612 SIX3
1118 regulation of cation channel activity (GO:2001257) 1/62 0.7314513 1 0 0 0.7698822 0.2407612 JPH2
1119 positive regulation of cell morphogenesis involved in differentiation (GO:0010770) 2/123 0.7323212 1 0 0 0.7761414 0.2417960 NTRK2;CUX2
1120 cellular response to steroid hormone stimulus (GO:0071383) 2/123 0.7323212 1 0 0 0.7761414 0.2417960 STC1;NKX3-1
1121 divalent inorganic cation homeostasis (GO:0072507) 5/291 0.7325019 1 0 0 0.8201494 0.2553038 JPH2;C1QTNF1;EDN2;STC1;TNNI3
1122 regulation of response to DNA damage stimulus (GO:2001020) 2/124 0.7364074 1 0 0 0.7698822 0.2355622 MUC1;NKX3-1
1123 positive regulation of endothelial cell proliferation (GO:0001938) 1/63 0.7370948 1 0 0 0.7576619 0.2311162 CCL24
1124 positive regulation of T cell differentiation (GO:0045582) 1/63 0.7370948 1 0 0 0.7576619 0.2311162 ZBTB16
1125 regulation of alpha-beta T cell activation (GO:0046634) 1/63 0.7370948 1 0 0 0.7576619 0.2311162 ZBTB16
1126 regulation of blood vessel size (GO:0050880) 1/63 0.7370948 1 0 0 0.7576619 0.2311162 EDN2
1127 regulation of neurotransmitter transport (GO:0051588) 1/63 0.7370948 1 0 0 0.7576619 0.2311162 NTRK2
1128 divalent inorganic cation transport (GO:0072511) 4/238 0.7376519 1 0 0 0.8022302 0.2441052 JPH2;TCN1;BHLHA15;CACNA1E
1129 negative regulation of cellular component movement (GO:0051271) 3/183 0.7409391 1 0 0 0.7825032 0.2346233 STC1;ALOX15B;THBS1
1130 negative regulation of angiogenesis (GO:0016525) 1/64 0.7426200 1 0 0 0.7458234 0.2219352 THBS1
1131 regulation of tube size (GO:0035150) 1/64 0.7426200 1 0 0 0.7458234 0.2219352 EDN2
1132 regulation of synapse organization (GO:0050807) 1/64 0.7426200 1 0 0 0.7458234 0.2219352 CUX2
1133 positive regulation of stem cell proliferation (GO:2000648) 1/64 0.7426200 1 0 0 0.7458234 0.2219352 PAX6
1134 regulation of actin cytoskeleton organization (GO:0032956) 4/240 0.7435496 1 0 0 0.7955449 0.2357357 CCL24;CSF3;CDC42EP5;MYLK3
1135 negative regulation of sequence-specific DNA binding transcription factor activity (GO:0043433) 2/126 0.7444207 1 0 0 0.7576619 0.2236231 IRAK3;PTHLH
1136 negative regulation of Wnt signaling pathway (GO:0030178) 2/126 0.7444207 1 0 0 0.7576619 0.2236231 SIX3;CTHRC1
1137 glutamine family amino acid metabolic process (GO:0009064) 1/65 0.7480294 1 0 0 0.7343492 0.2131911 PYCR1
1138 negative regulation of ossification (GO:0030279) 1/65 0.7480294 1 0 0 0.7343492 0.2131911 AHSG
1139 negative regulation of NF-kappaB transcription factor activity (GO:0032088) 1/65 0.7480294 1 0 0 0.7343492 0.2131911 IRAK3
1140 negative regulation of lipid metabolic process (GO:0045833) 1/65 0.7480294 1 0 0 0.7343492 0.2131911 ADRA2A
1141 positive regulation of peptide hormone secretion (GO:0090277) 1/65 0.7480294 1 0 0 0.7343492 0.2131911 DOC2B
1142 circadian rhythm (GO:0007623) 2/127 0.7483486 1 0 0 0.7516960 0.2179064 NTRK2;SIX3
1143 calcium ion transmembrane transport (GO:0070588) 2/128 0.7522246 1 0 0 0.7458234 0.2123511 JPH2;CACNA1E
1144 amino acid transport (GO:0006865) 2/128 0.7522246 1 0 0 0.7458234 0.2123511 NTRK2;SLC6A1
1145 regulation of acute inflammatory response (GO:0002673) 1/66 0.7533254 1 0 0 0.7232227 0.2048586 PTGS2
1146 positive regulation of translation (GO:0045727) 1/66 0.7533254 1 0 0 0.7232227 0.2048586 THBS1
1147 negative regulation of blood vessel morphogenesis (GO:2000181) 1/66 0.7533254 1 0 0 0.7232227 0.2048586 THBS1
1148 response to ammonium ion (GO:0060359) 1/66 0.7533254 1 0 0 0.7232227 0.2048586 SLC6A1
1149 negative regulation of apoptotic signaling pathway (GO:2001234) 3/187 0.7540389 1 0 0 0.7657652 0.2161841 MUC1;IL19;THBS1
1150 negative regulation of hydrolase activity (GO:0051346) 6/354 0.7545712 1 0 0 0.8090288 0.2278271 SERPINB4;AHSG;HMSD;SSPO;TNNI3;THBS1
1151 regulation of lipid metabolic process (GO:0019216) 4/245 0.7578527 1 0 0 0.7793093 0.2160761 APOB;PTGS2;ADRA2A;CYP17A1
1152 positive regulation of peptide secretion (GO:0002793) 1/67 0.7585103 1 0 0 0.7124283 0.1969144 DOC2B
1153 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:0006977) 1/67 0.7585103 1 0 0 0.7124283 0.1969144 MUC1
1154 cellular response to mechanical stimulus (GO:0071260) 1/67 0.7585103 1 0 0 0.7124283 0.1969144 PTGS2
1155 regulation of inflammatory response (GO:0050727) 4/247 0.7633989 1 0 0 0.7729991 0.2086901 CCL24;AHSG;ADORA3;PTGS2
1156 negative regulation of catabolic process (GO:0009895) 3/190 0.7635108 1 0 0 0.7536742 0.2033624 IRAK3;TNNI3;ADRA2A
1157 cellular lipid catabolic process (GO:0044242) 2/131 0.7635456 1 0 0 0.7287435 0.1966022 LIPG;APOB
1158 cytokine production (GO:0001816) 1/68 0.7635865 1 0 0 0.7019514 0.1893366 PTGS2
1159 signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) 1/68 0.7635865 1 0 0 0.7019514 0.1893366 MUC1
1160 intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) 1/68 0.7635865 1 0 0 0.7019514 0.1893366 MUC1
1161 positive regulation of cell development (GO:0010720) 6/358 0.7639254 1 0 0 0.7999893 0.2154252 NTRK2;CUX2;BRINP1;PAX6;FEZF1;MYLK3
1162 cellular response to biotic stimulus (GO:0071216) 2/132 0.7672185 1 0 0 0.7232227 0.1916422 CSF3;CYP17A1
1163 positive regulation of lymphocyte mediated immunity (GO:0002708) 1/69 0.7685562 1 0 0 0.6917782 0.1821048 AZGP1
1164 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process (GO:0043154) 1/69 0.7685562 1 0 0 0.6917782 0.1821048 THBS1
1165 alpha-amino acid biosynthetic process (GO:1901607) 1/69 0.7685562 1 0 0 0.6917782 0.1821048 PYCR1
1166 positive regulation of cytokine secretion (GO:0050715) 1/69 0.7685562 1 0 0 0.6917782 0.1821048 ALOX15B
1167 signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) 1/69 0.7685562 1 0 0 0.6917782 0.1821048 MUC1
1168 signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) 1/69 0.7685562 1 0 0 0.6917782 0.1821048 MUC1
1169 signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) 1/69 0.7685562 1 0 0 0.6917782 0.1821048 MUC1
1170 negative regulation of myeloid cell differentiation (GO:0045638) 1/69 0.7685562 1 0 0 0.6917782 0.1821048 ZBTB16
1171 adherens junction organization (GO:0034332) 1/69 0.7685562 1 0 0 0.6917782 0.1821048 CDH15
1172 negative regulation of transport (GO:0051051) 6/361 0.7707671 1 0 0 0.7933412 0.2065615 BMP8A;STC1;PTGS2;THBS1;ADRA2A;STXBP5L
1173 activation of MAPK activity (GO:0000187) 2/133 0.7708418 1 0 0 0.7177849 0.1868194 THBS1;ADRA2A
1174 positive regulation of immune effector process (GO:0002699) 2/133 0.7708418 1 0 0 0.7177849 0.1868194 AZGP1;ADORA3
1175 regulation of vesicle-mediated transport (GO:0060627) 5/306 0.7712574 1 0 0 0.7799460 0.2025778 AHSG;ADORA3;DOC2B;ADRA2A;STXBP5L
1176 lipid transport (GO:0006869) 3/193 0.7726851 1 0 0 0.7419590 0.1913392 LIPG;ATP10B;APOB
1177 single-organism behavior (GO:0044708) 6/362 0.7730146 1 0 0 0.7911497 0.2036873 NTRK2;CUX2;PCDH15;SLC6A1;PTGS2;THBS1
1178 hormone secretion (GO:0046879) 1/70 0.7734217 1 0 0 0.6818957 0.1752000 ADORA3
1179 negative regulation of vasculature development (GO:1901343) 1/70 0.7734217 1 0 0 0.6818957 0.1752000 THBS1
1180 response to heat (GO:0009408) 1/70 0.7734217 1 0 0 0.6818957 0.1752000 THBS1
1181 cellular response to cytokine stimulus (GO:0071345) 8/471 0.7736317 1 0 0 0.8107464 0.2080856 CSF3;EDN2;IL1R2;IRAK3;APOB;THBS1;MYLK3;NKX3-1
1182 cell fate commitment (GO:0045165) 2/134 0.7744158 1 0 0 0.7124283 0.1821297 PAX6;WNT16
1183 pyruvate metabolic process (GO:0006090) 1/71 0.7781852 1 0 0 0.6722915 0.1686045 HKDC1
1184 tissue remodeling (GO:0048771) 1/71 0.7781852 1 0 0 0.6722915 0.1686045 WNT16
1185 signal transduction involved in DNA damage checkpoint (GO:0072422) 1/71 0.7781852 1 0 0 0.6722915 0.1686045 MUC1
1186 striated muscle contraction (GO:0006941) 1/71 0.7781852 1 0 0 0.6722915 0.1686045 TNNI3
1187 negative regulation of cysteine-type endopeptidase activity (GO:2000117) 1/71 0.7781852 1 0 0 0.6722915 0.1686045 THBS1
1188 signal transduction involved in DNA integrity checkpoint (GO:0072401) 1/71 0.7781852 1 0 0 0.6722915 0.1686045 MUC1
1189 regulation of epidermal growth factor receptor signaling pathway (GO:0042058) 1/71 0.7781852 1 0 0 0.6722915 0.1686045 ADRA2A
1190 receptor metabolic process (GO:0043112) 1/71 0.7781852 1 0 0 0.6722915 0.1686045 REP15
1191 organophosphate ester transport (GO:0015748) 1/71 0.7781852 1 0 0 0.6722915 0.1686045 ATP10B
1192 positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains (GO:0002824) 1/71 0.7781852 1 0 0 0.6722915 0.1686045 AZGP1
1193 renal system process (GO:0003014) 1/71 0.7781852 1 0 0 0.6722915 0.1686045 HSD11B2
1194 body fluid secretion (GO:0007589) 1/71 0.7781852 1 0 0 0.6722915 0.1686045 CHRM1
1195 biomineral tissue development (GO:0031214) 1/71 0.7781852 1 0 0 0.6722915 0.1686045 PTGS2
1196 positive regulation of cell projection organization (GO:0031346) 3/195 0.7786383 1 0 0 0.7343492 0.1837405 NTRK2;CUX2;CDC42EP5
1197 smoothened signaling pathway (GO:0007224) 1/72 0.7828487 1 0 0 0.6629541 0.1623016 PAX6
1198 regulation of fatty acid metabolic process (GO:0019217) 1/72 0.7828487 1 0 0 0.6629541 0.1623016 PTGS2
1199 regulation of heart rate (GO:0002027) 1/72 0.7828487 1 0 0 0.6629541 0.1623016 EDN2
1200 positive regulation of chromosome organization (GO:2001252) 1/72 0.7828487 1 0 0 0.6629541 0.1623016 MUC1
1201 signal transduction involved in cell cycle checkpoint (GO:0072395) 1/72 0.7828487 1 0 0 0.6629541 0.1623016 MUC1
1202 response to metal ion (GO:0010038) 4/255 0.7846000 1 0 0 0.7487482 0.1816322 TFF1;SLC6A1;PTGS2;THBS1
1203 regulation of ion transmembrane transporter activity (GO:0032412) 2/137 0.7848476 1 0 0 0.6968277 0.1688175 JPH2;ADRA2A
1204 positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway (GO:0090100) 1/73 0.7874144 1 0 0 0.6538726 0.1562759 THBS1
1205 negative regulation of transforming growth factor beta receptor signaling pathway (GO:0030512) 1/73 0.7874144 1 0 0 0.6538726 0.1562759 FBN2
1206 intracellular steroid hormone receptor signaling pathway (GO:0030518) 1/73 0.7874144 1 0 0 0.6538726 0.1562759 NKX3-1
1207 positive regulation of nervous system development (GO:0051962) 5/313 0.7878191 1 0 0 0.7625031 0.1818469 NTRK2;CUX2;BRINP1;PAX6;FEZF1
1208 negative regulation of response to wounding (GO:1903035) 2/138 0.7882296 1 0 0 0.6917782 0.1646196 C1QTNF1;PLAT
1209 positive regulation of peptidyl-tyrosine phosphorylation (GO:0050731) 2/139 0.7915648 1 0 0 0.6868014 0.1605354 CSF3;ADRA2A
1210 positive regulation of adaptive immune response (GO:0002821) 1/74 0.7918844 1 0 0 0.6450364 0.1505127 AZGP1
1211 negative regulation of MAP kinase activity (GO:0043407) 1/74 0.7918844 1 0 0 0.6450364 0.1505127 IRAK3
1212 cellular response to starvation (GO:0009267) 1/74 0.7918844 1 0 0 0.6450364 0.1505127 FOXA3
1213 regulation of ERBB signaling pathway (GO:1901184) 1/74 0.7918844 1 0 0 0.6450364 0.1505127 ADRA2A
1214 spindle organization (GO:0007051) 1/74 0.7918844 1 0 0 0.6450364 0.1505127 NEK6
1215 regulation of epithelial cell proliferation (GO:0050678) 4/258 0.7921515 1 0 0 0.7400418 0.1724317 CCL24;PAX6;THBS1;NKX3-1
1216 regulation of peptidase activity (GO:0052547) 6/372 0.7945911 1 0 0 0.7698822 0.1770172 SERPINB4;AHSG;HMSD;SSPO;THBS1;NKX3-1
1217 cell-substrate adhesion (GO:0031589) 2/140 0.7948536 1 0 0 0.6818957 0.1565614 ITGA10;NID2
1218 glycoprotein metabolic process (GO:0009100) 1/75 0.7962606 1 0 0 0.6364360 0.1449984 B3GNT6
1219 hormone transport (GO:0009914) 1/75 0.7962606 1 0 0 0.6364360 0.1449984 ADORA3
1220 negative regulation of intrinsic apoptotic signaling pathway (GO:2001243) 1/75 0.7962606 1 0 0 0.6364360 0.1449984 MUC1
1221 wound healing (GO:0042060) 1/75 0.7962606 1 0 0 0.6364360 0.1449984 PLAT
1222 positive regulation of lymphocyte differentiation (GO:0045621) 1/75 0.7962606 1 0 0 0.6364360 0.1449984 ZBTB16
1223 regulation of transmembrane transporter activity (GO:0022898) 2/141 0.7980965 1 0 0 0.6770595 0.1526943 JPH2;ADRA2A
1224 response to reactive oxygen species (GO:0000302) 2/141 0.7980965 1 0 0 0.6770595 0.1526943 TPO;PXDN
1225 negative regulation of cell cycle (GO:0045786) 7/430 0.7998336 1 0 0 0.7770439 0.1735540 CGREF1;MUC1;BRINP1;PTGS2;ALOX15B;THBS1;NKX3-1
1226 homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156) 2/142 0.8012940 1 0 0 0.6722915 0.1489309 PCDH15;CDH15
1227 response to toxic substance (GO:0009636) 2/142 0.8012940 1 0 0 0.6722915 0.1489309 SLC6A1;CYP17A1
1228 negative regulation of locomotion (GO:0040013) 3/204 0.8038593 1 0 0 0.7019514 0.1532577 STC1;ALOX15B;THBS1
1229 regulation of protein import into nucleus (GO:0042306) 2/143 0.8044466 1 0 0 0.6675902 0.1452681 CSF3;PTGS2
1230 DNA damage checkpoint (GO:0000077) 1/77 0.8047394 1 0 0 0.6199052 0.1346662 NEK6
1231 regulation of smooth muscle cell proliferation (GO:0048660) 1/77 0.8047394 1 0 0 0.6199052 0.1346662 PTGS2
1232 regulation of oxidoreductase activity (GO:0051341) 1/77 0.8047394 1 0 0 0.6199052 0.1346662 EDN2
1233 positive regulation of neuron projection development (GO:0010976) 2/144 0.8075547 1 0 0 0.6629541 0.1417028 NTRK2;CUX2
1234 positive regulation of peptidyl-serine phosphorylation (GO:0033138) 1/78 0.8088459 1 0 0 0.6119577 0.1298249 CSF3
1235 regulation of cell-matrix adhesion (GO:0001952) 1/78 0.8088459 1 0 0 0.6119577 0.1298249 THBS1
1236 regulation of membrane potential (GO:0042391) 4/266 0.8112544 1 0 0 0.7177849 0.1501416 ANO1;CUX2;PYCR1;CACNA1E
1237 regulation of production of molecular mediator of immune response (GO:0002700) 1/79 0.8128663 1 0 0 0.6042114 0.1251858 IRAK3
1238 multicellular organism growth (GO:0035264) 1/79 0.8128663 1 0 0 0.6042114 0.1251858 PCDH15
1239 developmental growth involved in morphogenesis (GO:0060560) 1/79 0.8128663 1 0 0 0.6042114 0.1251858 PTHLH
1240 cytokinesis (GO:0000910) 1/79 0.8128663 1 0 0 0.6042114 0.1251858 NEK6
1241 neuromuscular process (GO:0050905) 1/79 0.8128663 1 0 0 0.6042114 0.1251858 PCDH15
1242 behavior (GO:0007610) 8/494 0.8158309 1 0 0 0.7729991 0.1573426 NTRK2;CUX2;ADM2;SIX3;PCDH15;SLC6A1;PTGS2;THBS1
1243 negative regulation of neuron differentiation (GO:0045665) 2/147 0.8166169 1 0 0 0.6494244 0.1315638 SIX3;PAX6
1244 cell morphogenesis involved in differentiation (GO:0000904) 2/147 0.8166169 1 0 0 0.6494244 0.1315638 STC1;WNT16
1245 regulation of organelle assembly (GO:1902115) 1/80 0.8168022 1 0 0 0.5966587 0.1207388 MYLK3
1246 regulation of protein complex disassembly (GO:0043244) 1/80 0.8168022 1 0 0 0.5966587 0.1207388 IRAK3
1247 Ras protein signal transduction (GO:0007265) 2/148 0.8195518 1 0 0 0.6450364 0.1283607 CDC42EP5;ADRA2A
1248 organic anion transport (GO:0015711) 5/328 0.8201587 1 0 0 0.7276326 0.1442585 NTRK2;SLCO1B3;ATP10B;SLC6A1;SLC13A5
1249 retinoid metabolic process (GO:0001523) 1/81 0.8206556 1 0 0 0.5892926 0.1164747 APOB
1250 negative regulation of immune effector process (GO:0002698) 1/81 0.8206556 1 0 0 0.5892926 0.1164747 IRAK3
1251 protein heterooligomerization (GO:0051291) 1/81 0.8206556 1 0 0 0.5892926 0.1164747 C1QTNF1
1252 regulation of reactive oxygen species metabolic process (GO:2000377) 1/81 0.8206556 1 0 0 0.5892926 0.1164747 THBS1
1253 regulation of cellular amine metabolic process (GO:0033238) 1/82 0.8244281 1 0 0 0.5821061 0.1123845 GPR37
1254 male gonad development (GO:0008584) 1/82 0.8244281 1 0 0 0.5821061 0.1123845 NKX3-1
1255 MyD88-dependent toll-like receptor signaling pathway (GO:0002755) 1/82 0.8244281 1 0 0 0.5821061 0.1123845 IRAK3
1256 organic acid biosynthetic process (GO:0016053) 4/272 0.8246228 1 0 0 0.7019514 0.1353567 EDN2;PYCR1;PTGS2;ALOX15B
1257 carboxylic acid biosynthetic process (GO:0046394) 4/272 0.8246228 1 0 0 0.7019514 0.1353567 EDN2;PYCR1;PTGS2;ALOX15B
1258 positive regulation of defense response (GO:0031349) 4/272 0.8246228 1 0 0 0.7019514 0.1353567 CCL24;ADORA3;IRAK3;PTGS2
1259 actin filament organization (GO:0007015) 2/150 0.8252959 1 0 0 0.6364360 0.1222042 PCDH15;SHROOM1
1260 regulation of organ morphogenesis (GO:2000027) 2/150 0.8252959 1 0 0 0.6364360 0.1222042 CHAD;CTHRC1
1261 activation of cysteine-type endopeptidase activity involved in apoptotic process (GO:0006919) 1/83 0.8281214 1 0 0 0.5750927 0.1084599 NKX3-1
1262 myeloid leukocyte differentiation (GO:0002573) 1/83 0.8281214 1 0 0 0.5750927 0.1084599 CSF3
1263 calcium ion transport (GO:0006816) 3/215 0.8313669 1 0 0 0.6660376 0.1230065 JPH2;BHLHA15;CACNA1E
1264 integrin-mediated signaling pathway (GO:0007229) 1/84 0.8317373 1 0 0 0.5682464 0.1046930 ITGA10
1265 peptidyl-serine phosphorylation (GO:0018105) 1/84 0.8317373 1 0 0 0.5682464 0.1046930 NEK6
1266 regulation of interleukin-6 production (GO:0032675) 1/84 0.8317373 1 0 0 0.5682464 0.1046930 IRAK3
1267 post-embryonic development (GO:0009791) 1/84 0.8317373 1 0 0 0.5682464 0.1046930 APOB
1268 regulation of transporter activity (GO:0032409) 2/153 0.8336044 1 0 0 0.6239568 0.1135578 JPH2;ADRA2A
1269 nucleoside monophosphate biosynthetic process (GO:0009124) 1/85 0.8352772 1 0 0 0.5615611 0.1010763 ENTPD8
1270 positive regulation of cell cycle arrest (GO:0071158) 1/85 0.8352772 1 0 0 0.5615611 0.1010763 MUC1
1271 cellular response to light stimulus (GO:0071482) 1/85 0.8352772 1 0 0 0.5615611 0.1010763 PTGS2
1272 myeloid cell differentiation (GO:0030099) 2/154 0.8362938 1 0 0 0.6199052 0.1108237 CSF3;ZBTB16
1273 positive regulation of MAPK cascade (GO:0043410) 6/395 0.8382122 1 0 0 0.7250536 0.1279603 NTRK2;C1QTNF1;GPR37;WNT16;THBS1;ADRA2A
1274 regulation of binding (GO:0051098) 3/218 0.8382708 1 0 0 0.6568720 0.1158815 CSF3;NKX3-1;CTHRC1
1275 cellular chemical homeostasis (GO:0055082) 7/452 0.8385671 1 0 0 0.7392232 0.1301482 JPH2;C1QTNF1;EDN2;HKDC1;STC1;TNNI3;FOXA3
1276 cell-type specific apoptotic process (GO:0097285) 1/86 0.8387428 1 0 0 0.5550314 0.0976029 SIX3
1277 myeloid leukocyte activation (GO:0002274) 1/86 0.8387428 1 0 0 0.5550314 0.0976029 EDN2
1278 DNA integrity checkpoint (GO:0031570) 1/86 0.8387428 1 0 0 0.5550314 0.0976029 NEK6
1279 negative regulation of homeostatic process (GO:0032845) 1/86 0.8387428 1 0 0 0.5550314 0.0976029 ADRA2A
1280 negative regulation of neuron death (GO:1901215) 2/155 0.8389439 1 0 0 0.6159058 0.1081601 NTRK2;CSF3
1281 multicellular organismal development (GO:0007275) 7/453 0.8401763 1 0 0 0.7375913 0.1284468 CSF3;CATSPERB;PAX6;WNT16;C8ORF22;SPDEF;NKX3-1
1282 negative regulation of mitotic cell cycle (GO:0045930) 3/219 0.8405173 1 0 0 0.6538726 0.1136023 MUC1;BRINP1;NKX3-1
1283 regulation of intracellular protein transport (GO:0033157) 3/219 0.8405173 1 0 0 0.6538726 0.1136023 CSF3;CHRM1;PTGS2
1284 regulation of protein localization to nucleus (GO:1900180) 2/156 0.8415551 1 0 0 0.6119577 0.1055650 CSF3;PTGS2
1285 triglyceride metabolic process (GO:0006641) 1/87 0.8421357 1 0 0 0.5486517 0.0942661 APOB
1286 regulation of receptor activity (GO:0010469) 1/87 0.8421357 1 0 0 0.5486517 0.0942661 ADRA2A
1287 diterpenoid metabolic process (GO:0016101) 1/87 0.8421357 1 0 0 0.5486517 0.0942661 APOB
1288 activation of cysteine-type endopeptidase activity (GO:0097202) 1/88 0.8454574 1 0 0 0.5424170 0.0910596 NKX3-1
1289 adult locomotory behavior (GO:0008344) 1/88 0.8454574 1 0 0 0.5424170 0.0910596 PCDH15
1290 sensory perception (GO:0007600) 7/457 0.8464860 1 0 0 0.7311354 0.1218522 OMP;SIX3;GRM8;PCDH15;PAX6;PTGS2;ADRA2A
1291 energy reserve metabolic process (GO:0006112) 2/158 0.8466628 1 0 0 0.6042114 0.1005726 CACNA1E;ADRA2A
1292 phototransduction, visible light (GO:0007603) 1/89 0.8487093 1 0 0 0.5363224 0.0879775 APOB
1293 chromosome segregation (GO:0007059) 1/89 0.8487093 1 0 0 0.5363224 0.0879775 NEK6
1294 RNA phosphodiester bond hydrolysis (GO:0090501) 1/89 0.8487093 1 0 0 0.5363224 0.0879775 AZGP1
1295 stress-activated MAPK cascade (GO:0051403) 1/89 0.8487093 1 0 0 0.5363224 0.0879775 CDC42EP5
1296 cell junction assembly (GO:0034329) 2/160 0.8516207 1 0 0 0.5966587 0.0958317 CDH15;FLNC
1297 water-soluble vitamin metabolic process (GO:0006767) 1/90 0.8518930 1 0 0 0.5303633 0.0850142 TCN1
1298 positive regulation of endocytosis (GO:0045807) 1/90 0.8518930 1 0 0 0.5303633 0.0850142 AHSG
1299 regulation of cellular response to stress (GO:0080135) 6/404 0.8531191 1 0 0 0.7089014 0.1126133 MUC1;GPR37;NEK6;PYCR1;WNT16;NKX3-1
1300 regulation of extrinsic apoptotic signaling pathway (GO:2001236) 2/161 0.8540446 1 0 0 0.5929528 0.0935513 IL19;THBS1
1301 regulation of protein secretion (GO:0050708) 2/161 0.8540446 1 0 0 0.5929528 0.0935513 ALOX15B;STXBP5L
1302 regulation of neuron differentiation (GO:0045664) 6/405 0.8547041 1 0 0 0.7071511 0.1110227 NTRK2;CUX2;BRINP1;SIX3;PAX6;FEZF1
1303 negative regulation of canonical Wnt signaling pathway (GO:0090090) 1/91 0.8550098 1 0 0 0.5245351 0.0821644 CTHRC1
1304 stress-activated protein kinase signaling cascade (GO:0031098) 1/91 0.8550098 1 0 0 0.5245351 0.0821644 CDC42EP5
1305 DNA damage response, signal transduction by p53 class mediator (GO:0030330) 1/91 0.8550098 1 0 0 0.5245351 0.0821644 MUC1
1306 leukocyte migration (GO:0050900) 3/226 0.8555008 1 0 0 0.6336199 0.0988879 CCL24;EDN2;APOB
1307 iron ion homeostasis (GO:0055072) 1/92 0.8580612 1 0 0 0.5188337 0.0794230 LCN2
1308 alpha-amino acid catabolic process (GO:1901606) 1/92 0.8580612 1 0 0 0.5188337 0.0794230 ALDH1L2
1309 acylglycerol metabolic process (GO:0006639) 1/93 0.8610486 1 0 0 0.5132548 0.0767852 APOB
1310 hormone-mediated signaling pathway (GO:0009755) 1/93 0.8610486 1 0 0 0.5132548 0.0767852 NKX3-1
1311 regulation of cytokine biosynthetic process (GO:0042035) 1/93 0.8610486 1 0 0 0.5132548 0.0767852 THBS1
1312 positive regulation of cell-substrate adhesion (GO:0010811) 1/93 0.8610486 1 0 0 0.5132548 0.0767852 THBS1
1313 regulation of glucose metabolic process (GO:0010906) 1/94 0.8639732 1 0 0 0.5077946 0.0742465 C1QTNF1
1314 regulation of cell-cell adhesion (GO:0022407) 1/94 0.8639732 1 0 0 0.5077946 0.0742465 C1QTNF1
1315 neutral lipid metabolic process (GO:0006638) 1/94 0.8639732 1 0 0 0.5077946 0.0742465 APOB
1316 regulation of behavior (GO:0050795) 2/166 0.8656311 1 0 0 0.5750927 0.0829838 EDN2;THBS1
1317 regulation of endopeptidase activity (GO:0052548) 5/354 0.8667283 1 0 0 0.6741906 0.0964293 SERPINB4;AHSG;HMSD;THBS1;NKX3-1
1318 response to drug (GO:0042493) 5/354 0.8667283 1 0 0 0.6741906 0.0964293 HSD11B2;PTGS2;THBS1;CYP17A1;NKX3-1
1319 regulation of lymphocyte mediated immunity (GO:0002706) 1/95 0.8668363 1 0 0 0.5024494 0.0718026 AZGP1
1320 purine nucleoside biosynthetic process (GO:0042451) 1/95 0.8668363 1 0 0 0.5024494 0.0718026 SLC26A2
1321 negative regulation of binding (GO:0051100) 1/95 0.8668363 1 0 0 0.5024494 0.0718026 NKX3-1
1322 cellular hormone metabolic process (GO:0034754) 1/95 0.8668363 1 0 0 0.5024494 0.0718026 CYP17A1
1323 purine ribonucleoside biosynthetic process (GO:0046129) 1/95 0.8668363 1 0 0 0.5024494 0.0718026 SLC26A2
1324 regulation of protein targeting (GO:1903533) 2/167 0.8678449 1 0 0 0.5716491 0.0810269 CSF3;PTGS2
1325 heart development (GO:0007507) 2/167 0.8678449 1 0 0 0.5716491 0.0810269 TNNI3;NKX3-1
1326 fat cell differentiation (GO:0045444) 1/96 0.8696394 1 0 0 0.4972156 0.0694494 PTGS2
1327 positive regulation of I-kappaB kinase/NF-kappaB signaling (GO:0043123) 2/168 0.8700252 1 0 0 0.5682464 0.0791187 NEK6;PTGS2
1328 divalent metal ion transport (GO:0070838) 3/234 0.8711076 1 0 0 0.6119577 0.0844439 JPH2;BHLHA15;CACNA1E
1329 peptidyl-serine modification (GO:0018209) 1/97 0.8723836 1 0 0 0.4920897 0.0671831 NEK6
1330 regulation of histone modification (GO:0031056) 1/97 0.8723836 1 0 0 0.4920897 0.0671831 MUC1
1331 terpenoid metabolic process (GO:0006721) 1/97 0.8723836 1 0 0 0.4920897 0.0671831 APOB
1332 negative regulation of protein catabolic process (GO:0042177) 1/97 0.8723836 1 0 0 0.4920897 0.0671831 IRAK3
1333 regulation of T cell differentiation (GO:0045580) 1/97 0.8723836 1 0 0 0.4920897 0.0671831 ZBTB16
1334 angiogenesis (GO:0001525) 3/236 0.8747695 1 0 0 0.6067716 0.0811829 ADM2;PTGS2;THBS1
1335 regulation of peptidyl-serine phosphorylation (GO:0033135) 1/98 0.8750701 1 0 0 0.4870683 0.0649999 CSF3
1336 cellular metal ion homeostasis (GO:0006875) 5/361 0.8773846 1 0 0 0.6611177 0.0864807 JPH2;C1QTNF1;EDN2;STC1;TNNI3
1337 cellular response to nutrient levels (GO:0031669) 1/99 0.8777003 1 0 0 0.4821485 0.0628963 FOXA3
1338 negative regulation of G1/S transition of mitotic cell cycle (GO:2000134) 1/99 0.8777003 1 0 0 0.4821485 0.0628963 MUC1
1339 negative regulation of cell cycle G1/S phase transition (GO:1902807) 1/99 0.8777003 1 0 0 0.4821485 0.0628963 MUC1
1340 DNA conformation change (GO:0071103) 1/99 0.8777003 1 0 0 0.4821485 0.0628963 RTEL1-TNFRSF6B
1341 metal ion homeostasis (GO:0055065) 6/422 0.8795660 1 0 0 0.6786639 0.0870906 JPH2;C1QTNF1;EDN2;LCN2;STC1;TNNI3
1342 actin filament-based process (GO:0030029) 4/303 0.8817532 1 0 0 0.6301346 0.0792981 DAAM2;TNNI3;MYLK3;ADRA2A
1343 regulation of Rho GTPase activity (GO:0032319) 2/174 0.8824274 1 0 0 0.5486517 0.0686247 CCL24;NTRK2
1344 protein localization to nucleus (GO:0034504) 1/101 0.8827960 1 0 0 0.4726010 0.0589150 ZBTB16
1345 detection of external stimulus (GO:0009581) 2/175 0.8843850 1 0 0 0.5455165 0.0670237 PCDH15;APOB
1346 hematopoietic or lymphoid organ development (GO:0048534) 2/175 0.8843850 1 0 0 0.5455165 0.0670237 TPO;ZBTB16
1347 regulation of chromatin modification (GO:1903308) 1/102 0.8852638 1 0 0 0.4679676 0.0570310 MUC1
1348 peptidyl-tyrosine dephosphorylation (GO:0035335) 1/102 0.8852638 1 0 0 0.4679676 0.0570310 PTPRH
1349 neuron projection guidance (GO:0097485) 5/367 0.8859348 1 0 0 0.6503092 0.0787602 UNC5A;ITGA10;SEMA3B;PAX6;FEZF1
1350 axon guidance (GO:0007411) 5/367 0.8859348 1 0 0 0.6503092 0.0787602 UNC5A;ITGA10;SEMA3B;PAX6;FEZF1
1351 regulation of cellular response to growth factor stimulus (GO:0090287) 2/176 0.8863125 1 0 0 0.5424170 0.0654620 FBN2;THBS1
1352 positive regulation of mitotic cell cycle (GO:0045931) 1/103 0.8876798 1 0 0 0.4634242 0.0552143 NKX3-1
1353 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains (GO:0002822) 1/103 0.8876798 1 0 0 0.4634242 0.0552143 AZGP1
1354 negative regulation of immune response (GO:0050777) 1/103 0.8876798 1 0 0 0.4634242 0.0552143 IRAK3
1355 regulation of protein complex assembly (GO:0043254) 3/244 0.8885121 1 0 0 0.5868774 0.0693730 CCL24;CSF3;CDC42EP5
1356 detection of visible light (GO:0009584) 1/104 0.8900451 1 0 0 0.4589682 0.0534621 APOB
1357 antigen processing and presentation of peptide antigen via MHC class I (GO:0002474) 1/104 0.8900451 1 0 0 0.4589682 0.0534621 AZGP1
1358 detection of abiotic stimulus (GO:0009582) 2/178 0.8900786 1 0 0 0.5363224 0.0624523 PCDH15;APOB
1359 regulation of nucleocytoplasmic transport (GO:0046822) 2/178 0.8900786 1 0 0 0.5363224 0.0624523 CSF3;PTGS2
1360 regulation of cell cycle arrest (GO:0071156) 1/105 0.8923606 1 0 0 0.4545971 0.0517718 MUC1
1361 response to starvation (GO:0042594) 1/106 0.8946275 1 0 0 0.4503085 0.0501409 FOXA3
1362 cellular amino acid biosynthetic process (GO:0008652) 1/106 0.8946275 1 0 0 0.4503085 0.0501409 PYCR1
1363 signal transduction in response to DNA damage (GO:0042770) 1/106 0.8946275 1 0 0 0.4503085 0.0501409 MUC1
1364 regulation of cytokine secretion (GO:0050707) 1/106 0.8946275 1 0 0 0.4503085 0.0501409 ALOX15B
1365 cell growth (GO:0016049) 1/106 0.8946275 1 0 0 0.4503085 0.0501409 LEFTY1
1366 response to glucose (GO:0009749) 1/106 0.8946275 1 0 0 0.4503085 0.0501409 THBS1
1367 synaptic transmission (GO:0007268) 6/434 0.8948836 1 0 0 0.6598990 0.0732894 CHRM1;OMP;KCNN2;PLAT;SLC6A1;CACNA1E
1368 negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway (GO:0090101) 1/107 0.8968468 1 0 0 0.4461000 0.0485670 FBN2
1369 cholesterol metabolic process (GO:0008203) 1/107 0.8968468 1 0 0 0.4461000 0.0485670 APOB
1370 regulation of chromatin organization (GO:1902275) 1/107 0.8968468 1 0 0 0.4461000 0.0485670 MUC1
1371 positive regulation of JNK cascade (GO:0046330) 1/107 0.8968468 1 0 0 0.4461000 0.0485670 WNT16
1372 maintenance of protein location (GO:0045185) 1/108 0.8990194 1 0 0 0.4419694 0.0470479 FBN2
1373 phototransduction (GO:0007602) 1/109 0.9011464 1 0 0 0.4379147 0.0455814 APOB
1374 cell recognition (GO:0008037) 1/109 0.9011464 1 0 0 0.4379147 0.0455814 CATSPERB
1375 regulation of protein transport (GO:0051223) 5/379 0.9015132 1 0 0 0.6297190 0.0652896 CSF3;CHRM1;PTGS2;ALOX15B;STXBP5L
1376 actin cytoskeleton organization (GO:0030036) 3/253 0.9023500 1 0 0 0.5660004 0.0581582 DAAM2;MYLK3;ADRA2A
1377 negative regulation of cytokine production (GO:0001818) 2/185 0.9023675 1 0 0 0.5160292 0.0530134 IRAK3;THBS1
1378 cellular response to external stimulus (GO:0071496) 2/185 0.9023675 1 0 0 0.5160292 0.0530134 PTGS2;FOXA3
1379 ribonucleoside biosynthetic process (GO:0042455) 1/110 0.9032287 1 0 0 0.4339336 0.0441655 SLC26A2
1380 regulation of cysteine-type endopeptidase activity involved in apoptotic process (GO:0043281) 2/186 0.9040148 1 0 0 0.5132548 0.0517923 THBS1;NKX3-1
1381 cellular component assembly involved in morphogenesis (GO:0010927) 2/186 0.9040148 1 0 0 0.5132548 0.0517923 PCDH15;MYLK3
1382 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway (GO:0090092) 2/186 0.9040148 1 0 0 0.5132548 0.0517923 FBN2;THBS1
1383 response to alkaloid (GO:0043279) 1/111 0.9052673 1 0 0 0.4300243 0.0427982 SLC6A1
1384 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process (GO:0043280) 1/111 0.9052673 1 0 0 0.4300243 0.0427982 NKX3-1
1385 synapse organization (GO:0050808) 1/111 0.9052673 1 0 0 0.4300243 0.0427982 NTRK2
1386 mitochondrial transport (GO:0006839) 1/111 0.9052673 1 0 0 0.4300243 0.0427982 BHLHA15
1387 hexose metabolic process (GO:0019318) 2/187 0.9056361 1 0 0 0.5105101 0.0506006 FUT6;HKDC1
1388 regulation of mitosis (GO:0007088) 1/112 0.9072629 1 0 0 0.4261848 0.0414776 NEK6
1389 regulation of striated muscle tissue development (GO:0016202) 1/112 0.9072629 1 0 0 0.4261848 0.0414776 JPH2
1390 gonad development (GO:0008406) 1/112 0.9072629 1 0 0 0.4261848 0.0414776 NKX3-1
1391 regulation of adaptive immune response (GO:0002819) 1/112 0.9072629 1 0 0 0.4261848 0.0414776 AZGP1
1392 cell junction organization (GO:0034330) 2/189 0.9088024 1 0 0 0.5051079 0.0483022 CDH15;FLNC
1393 regulation of peptidyl-tyrosine phosphorylation (GO:0050730) 2/189 0.9088024 1 0 0 0.5051079 0.0483022 CSF3;ADRA2A
1394 peptide metabolic process (GO:0006518) 1/113 0.9092167 1 0 0 0.4224132 0.0402018 CPE
1395 regulation of muscle tissue development (GO:1901861) 1/113 0.9092167 1 0 0 0.4224132 0.0402018 JPH2
1396 cell-cell adhesion via plasma-membrane adhesion molecules (GO:0098742) 2/190 0.9103481 1 0 0 0.5024494 0.0471942 PCDH15;CDH15
1397 regulation of muscle organ development (GO:0048634) 1/114 0.9111294 1 0 0 0.4187079 0.0389693 JPH2
1398 neuropeptide signaling pathway (GO:0007218) 1/114 0.9111294 1 0 0 0.4187079 0.0389693 CPE
1399 isoprenoid metabolic process (GO:0006720) 1/114 0.9111294 1 0 0 0.4187079 0.0389693 APOB
1400 regulation of axonogenesis (GO:0050770) 1/114 0.9111294 1 0 0 0.4187079 0.0389693 NTRK2
1401 cell-cell adhesion (GO:0098609) 2/191 0.9118692 1 0 0 0.4998188 0.0461126 PCDH15;CDH15
1402 regulation of protein catabolic process (GO:0042176) 3/260 0.9120218 1 0 0 0.5507619 0.0507204 NEK6;IRAK3;ADRA2A
1403 cellular cation homeostasis (GO:0030003) 5/389 0.9130524 1 0 0 0.6135308 0.0558080 JPH2;C1QTNF1;EDN2;STC1;TNNI3
1404 negative regulation of neurogenesis (GO:0050768) 2/192 0.9133661 1 0 0 0.4972156 0.0450569 SIX3;PAX6
1405 positive regulation of cytokine production (GO:0001819) 4/327 0.9141706 1 0 0 0.5838862 0.0523968 PTGS2;ALOX15B;THBS1;ADRA2A
1406 positive regulation of leukocyte activation (GO:0002696) 3/262 0.9146211 1 0 0 0.5465576 0.0487777 ADORA3;ZBTB16;THBS1
1407 extracellular matrix disassembly (GO:0022617) 1/116 0.9148349 1 0 0 0.4114888 0.0366273 FBN2
1408 regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032434) 1/116 0.9148349 1 0 0 0.4114888 0.0366273 NEK6
1409 taxis (GO:0042330) 3/263 0.9158945 1 0 0 0.5444794 0.0478348 CCL24;EDN2;CXCL2
1410 chemotaxis (GO:0006935) 3/263 0.9158945 1 0 0 0.5444794 0.0478348 CCL24;EDN2;CXCL2
1411 growth (GO:0040007) 4/329 0.9164779 1 0 0 0.5803367 0.0506154 LEFTY1;PCDH15;BMP8A;PTHLH
1412 cellular amino acid catabolic process (GO:0009063) 1/117 0.9166295 1 0 0 0.4079718 0.0355147 ALDH1L2
1413 response to UV (GO:0009411) 1/117 0.9166295 1 0 0 0.4079718 0.0355147 PTGS2
1414 regulation of immune effector process (GO:0002697) 3/264 0.9171505 1 0 0 0.5424170 0.0469102 AZGP1;ADORA3;IRAK3
1415 regulation of cell cycle phase transition (GO:1901987) 3/264 0.9171505 1 0 0 0.5424170 0.0469102 MUC1;NEK6;SIX3
1416 muscle contraction (GO:0006936) 2/195 0.9177153 1 0 0 0.4895661 0.0420381 EDN2;TNNI3
1417 cilium assembly (GO:0042384) 1/118 0.9183864 1 0 0 0.4045144 0.0344392 PCDH15
1418 negative regulation of protein serine/threonine kinase activity (GO:0071901) 1/118 0.9183864 1 0 0 0.4045144 0.0344392 IRAK3
1419 positive regulation of leukocyte differentiation (GO:1902107) 1/118 0.9183864 1 0 0 0.4045144 0.0344392 ZBTB16
1420 positive regulation of stress-activated MAPK cascade (GO:0032874) 1/118 0.9183864 1 0 0 0.4045144 0.0344392 WNT16
1421 embryonic organ development (GO:0048568) 1/119 0.9201063 1 0 0 0.4011151 0.0333993 TPO
1422 cellular response to extracellular stimulus (GO:0031668) 1/119 0.9201063 1 0 0 0.4011151 0.0333993 FOXA3
1423 positive regulation of stress-activated protein kinase signaling cascade (GO:0070304) 1/119 0.9201063 1 0 0 0.4011151 0.0333993 WNT16
1424 nucleoside biosynthetic process (GO:0009163) 1/119 0.9201063 1 0 0 0.4011151 0.0333993 SLC26A2
1425 positive regulation of cysteine-type endopeptidase activity (GO:2001056) 1/119 0.9201063 1 0 0 0.4011151 0.0333993 NKX3-1
1426 muscle cell differentiation (GO:0042692) 1/119 0.9201063 1 0 0 0.4011151 0.0333993 CDH15
1427 regulation of cysteine-type endopeptidase activity (GO:2000116) 2/197 0.9204999 1 0 0 0.4845959 0.0401431 THBS1;NKX3-1
1428 positive regulation of MAP kinase activity (GO:0043406) 2/197 0.9204999 1 0 0 0.4845959 0.0401431 THBS1;ADRA2A
1429 positive regulation of cell division (GO:0051781) 1/120 0.9217900 1 0 0 0.3977725 0.0323937 NKX3-1
1430 regulation of cell projection assembly (GO:0060491) 1/120 0.9217900 1 0 0 0.3977725 0.0323937 CDC42EP5
1431 negative regulation of defense response (GO:0031348) 1/120 0.9217900 1 0 0 0.3977725 0.0323937 IRAK3
1432 glycosyl compound biosynthetic process (GO:1901659) 1/120 0.9217900 1 0 0 0.3977725 0.0323937 SLC26A2
1433 transition metal ion homeostasis (GO:0055076) 1/120 0.9217900 1 0 0 0.3977725 0.0323937 LCN2
1434 energy derivation by oxidation of organic compounds (GO:0015980) 2/198 0.9218588 1 0 0 0.4821485 0.0392291 CACNA1E;ADRA2A
1435 cellular modified amino acid metabolic process (GO:0006575) 2/199 0.9231959 1 0 0 0.4797256 0.0383367 TPO;ALDH1L2
1436 embryonic organ morphogenesis (GO:0048562) 1/121 0.9234384 1 0 0 0.3944851 0.0314212 PAX6
1437 detection of light stimulus (GO:0009583) 1/121 0.9234384 1 0 0 0.3944851 0.0314212 APOB
1438 plasma membrane organization (GO:0007009) 1/121 0.9234384 1 0 0 0.3944851 0.0314212 ANO7
1439 response to temperature stimulus (GO:0009266) 1/122 0.9250521 1 0 0 0.3912516 0.0304806 THBS1
1440 vitamin metabolic process (GO:0006766) 1/122 0.9250521 1 0 0 0.3912516 0.0304806 TCN1
1441 toll-like receptor signaling pathway (GO:0002224) 1/122 0.9250521 1 0 0 0.3912516 0.0304806 IRAK3
1442 cellular ion homeostasis (GO:0006873) 5/402 0.9262719 1 0 0 0.5936903 0.0454692 JPH2;C1QTNF1;EDN2;STC1;TNNI3
1443 positive regulation of cell activation (GO:0050867) 3/272 0.9266000 1 0 0 0.5264636 0.0401341 ADORA3;ZBTB16;THBS1
1444 positive regulation of multi-organism process (GO:0043902) 1/123 0.9266318 1 0 0 0.3880707 0.0295706 PLAT
1445 cation homeostasis (GO:0055080) 6/465 0.9269710 1 0 0 0.6159058 0.0467060 JPH2;C1QTNF1;EDN2;LCN2;STC1;TNNI3
1446 embryonic morphogenesis (GO:0048598) 5/403 0.9272110 1 0 0 0.5922171 0.0447563 FBN2;ZBTB16;SIX3;PAX6;CTHRC1
1447 regulation of MAP kinase activity (GO:0043405) 3/273 0.9277092 1 0 0 0.5245351 0.0393595 IRAK3;THBS1;ADRA2A
1448 regulation of lymphocyte differentiation (GO:0045619) 1/124 0.9281784 1 0 0 0.3849411 0.0286902 ZBTB16
1449 sensory perception of sound (GO:0007605) 1/124 0.9281784 1 0 0 0.3849411 0.0286902 PCDH15
1450 aging (GO:0007568) 2/204 0.9295640 1 0 0 0.4679676 0.0341802 NTRK2;WNT16
1451 cilium organization (GO:0044782) 1/125 0.9296924 1 0 0 0.3818616 0.0278383 PCDH15
1452 cytokine-mediated signaling pathway (GO:0019221) 4/342 0.9301713 1 0 0 0.5582772 0.0404117 CSF3;EDN2;IL1R2;IRAK3
1453 purine ribonucleotide biosynthetic process (GO:0009152) 1/126 0.9311745 1 0 0 0.3788309 0.0270139 SLC26A2
1454 positive regulation of NF-kappaB transcription factor activity (GO:0051092) 1/126 0.9311745 1 0 0 0.3788309 0.0270139 IRAK3
1455 cellular response to radiation (GO:0071478) 1/126 0.9311745 1 0 0 0.3788309 0.0270139 PTGS2
1456 nervous system development (GO:0007399) 3/277 0.9319940 1 0 0 0.5169606 0.0364090 SEMA6B;CHRM1;APOB
1457 response to ionizing radiation (GO:0010212) 1/127 0.9326255 1 0 0 0.3758480 0.0262160 CYP17A1
1458 sensory perception of mechanical stimulus (GO:0050954) 1/127 0.9326255 1 0 0 0.3758480 0.0262160 PCDH15
1459 coagulation (GO:0050817) 6/472 0.9328994 1 0 0 0.6067716 0.0421451 ITGA10;PLAT;APOB;THBS1;ADRA2A;F5
1460 blood coagulation (GO:0007596) 6/472 0.9328994 1 0 0 0.6067716 0.0421451 ITGA10;PLAT;APOB;THBS1;ADRA2A;F5
1461 organelle assembly (GO:0070925) 3/278 0.9330281 1 0 0 0.5151010 0.0357068 NEK6;PCDH15;MYLK3
1462 positive regulation of endopeptidase activity (GO:0010950) 1/128 0.9340460 1 0 0 0.3729117 0.0254436 NKX3-1
1463 fatty acid metabolic process (GO:0006631) 3/280 0.9350530 1 0 0 0.5114218 0.0343430 EDN2;PTGS2;ALOX15B
1464 nucleoside phosphate biosynthetic process (GO:1901293) 2/209 0.9354316 1 0 0 0.4567722 0.0304883 SLC26A2;ENTPD8
1465 cellular potassium ion transport (GO:0071804) 1/129 0.9354366 1 0 0 0.3700209 0.0246959 KCNN2
1466 potassium ion transmembrane transport (GO:0071805) 1/129 0.9354366 1 0 0 0.3700209 0.0246959 KCNN2
1467 regulation of G1/S transition of mitotic cell cycle (GO:2000045) 1/129 0.9354366 1 0 0 0.3700209 0.0246959 MUC1
1468 organelle localization (GO:0051640) 1/129 0.9354366 1 0 0 0.3700209 0.0246959 BHLHA15
1469 positive regulation of protein catabolic process (GO:0045732) 1/130 0.9367979 1 0 0 0.3671746 0.0239720 ADRA2A
1470 negative regulation of MAPK cascade (GO:0043409) 1/130 0.9367979 1 0 0 0.3671746 0.0239720 IRAK3
1471 positive regulation of homeostatic process (GO:0032846) 1/130 0.9367979 1 0 0 0.3671746 0.0239720 PTGS2
1472 regulation of cytoskeleton organization (GO:0051493) 4/350 0.9375583 1 0 0 0.5455165 0.0351729 CCL24;CSF3;CDC42EP5;MYLK3
1473 hemostasis (GO:0007599) 6/478 0.9376387 1 0 0 0.5991552 0.0385800 ITGA10;PLAT;APOB;THBS1;ADRA2A;F5
1474 negative regulation of nervous system development (GO:0051961) 2/211 0.9376466 1 0 0 0.4524426 0.0291292 SIX3;PAX6
1475 cell division (GO:0051301) 1/131 0.9381306 1 0 0 0.3643717 0.0232710 ZBTB16
1476 regulation of cell cycle G1/S phase transition (GO:1902806) 1/131 0.9381306 1 0 0 0.3643717 0.0232710 MUC1
1477 signal transduction by p53 class mediator (GO:0072331) 1/132 0.9394353 1 0 0 0.3616113 0.0225922 MUC1
1478 purine nucleotide biosynthetic process (GO:0006164) 1/132 0.9394353 1 0 0 0.3616113 0.0225922 SLC26A2
1479 regulation of I-kappaB kinase/NF-kappaB signaling (GO:0043122) 2/213 0.9397895 1 0 0 0.4481943 0.0278326 NEK6;PTGS2
1480 alpha-amino acid metabolic process (GO:1901605) 2/213 0.9397895 1 0 0 0.4481943 0.0278326 PYCR1;ALDH1L2
1481 negative regulation of neuron apoptotic process (GO:0043524) 1/133 0.9407125 1 0 0 0.3588925 0.0219347 NTRK2
1482 regulation of Wnt signaling pathway (GO:0030111) 2/214 0.9408346 1 0 0 0.4461000 0.0272067 SIX3;CTHRC1
1483 negative regulation of response to external stimulus (GO:0032102) 2/215 0.9418624 1 0 0 0.4440251 0.0265954 C1QTNF1;PLAT
1484 transforming growth factor beta receptor signaling pathway (GO:0007179) 1/134 0.9419629 1 0 0 0.3562142 0.0212978 LEFTY1
1485 amine metabolic process (GO:0009308) 1/134 0.9419629 1 0 0 0.3562142 0.0212978 SULT1C2
1486 regulation of apoptotic signaling pathway (GO:2001233) 4/356 0.9426257 1 0 0 0.5363224 0.0316892 MUC1;IL19;THBS1;NKX3-1
1487 response to unfolded protein (GO:0006986) 1/135 0.9431869 1 0 0 0.3535755 0.0206809 THBS1
1488 regulation of proteasomal protein catabolic process (GO:0061136) 1/135 0.9431869 1 0 0 0.3535755 0.0206809 NEK6
1489 negative regulation of cell activation (GO:0050866) 1/135 0.9431869 1 0 0 0.3535755 0.0206809 C1QTNF1
1490 cellular response to organic cyclic compound (GO:0071407) 3/291 0.9452165 1 0 0 0.4920897 0.0277250 STC1;PTGS2;NKX3-1
1491 regulation of cellular carbohydrate metabolic process (GO:0010675) 1/137 0.9455582 1 0 0 0.3484138 0.0195041 C1QTNF1
1492 regulation of G-protein coupled receptor protein signaling pathway (GO:0008277) 1/137 0.9455582 1 0 0 0.3484138 0.0195041 ADRA2A
1493 regulation of nuclear division (GO:0051783) 1/138 0.9467066 1 0 0 0.3458891 0.0189430 NEK6
1494 lipid biosynthetic process (GO:0008610) 6/491 0.9469014 1 0 0 0.5832916 0.0318246 HSD11B2;EDN2;TFCP2L1;PTGS2;ALOX15B;CYP17A1
1495 negative regulation of growth (GO:0045926) 2/221 0.9476823 1 0 0 0.4319701 0.0232123 CGREF1;ALOX15B
1496 monosaccharide metabolic process (GO:0005996) 2/221 0.9476823 1 0 0 0.4319701 0.0232123 FUT6;HKDC1
1497 positive regulation of peptidase activity (GO:0010952) 1/139 0.9478308 1 0 0 0.3434007 0.0183992 NKX3-1
1498 neuron differentiation (GO:0030182) 2/222 0.9485967 1 0 0 0.4300243 0.0226931 NTRK2;WNT16
1499 ribonucleotide biosynthetic process (GO:0009260) 1/140 0.9489314 1 0 0 0.3409478 0.0178721 SLC26A2
1500 adult behavior (GO:0030534) 1/141 0.9500087 1 0 0 0.3385298 0.0173612 PCDH15
1501 sodium ion transport (GO:0006814) 1/141 0.9500087 1 0 0 0.3385298 0.0173612 SLC13A5
1502 branching morphogenesis of an epithelial tube (GO:0048754) 1/141 0.9500087 1 0 0 0.3385298 0.0173612 NKX3-1
1503 pattern recognition receptor signaling pathway (GO:0002221) 1/142 0.9510635 1 0 0 0.3361458 0.0168659 IRAK3
1504 regulation of neuron death (GO:1901214) 2/225 0.9512495 1 0 0 0.4242906 0.0212056 NTRK2;CSF3
1505 response to topologically incorrect protein (GO:0035966) 1/143 0.9520960 1 0 0 0.3337951 0.0163858 THBS1
1506 ribose phosphate biosynthetic process (GO:0046390) 1/144 0.9531067 1 0 0 0.3314771 0.0159203 SLC26A2
1507 positive regulation of epithelial cell proliferation (GO:0050679) 1/144 0.9531067 1 0 0 0.3314771 0.0159203 CCL24
1508 innate immune response-activating signal transduction (GO:0002758) 1/144 0.9531067 1 0 0 0.3314771 0.0159203 IRAK3
1509 positive regulation of proteolysis (GO:0045862) 2/228 0.9537715 1 0 0 0.4187079 0.0198179 ADRA2A;NKX3-1
1510 regulation of carbohydrate metabolic process (GO:0006109) 1/145 0.9540962 1 0 0 0.3291910 0.0154689 C1QTNF1
1511 sulfur compound biosynthetic process (GO:0044272) 1/145 0.9540962 1 0 0 0.3291910 0.0154689 SLC26A2
1512 response to endoplasmic reticulum stress (GO:0034976) 1/145 0.9540962 1 0 0 0.3291910 0.0154689 THBS1
1513 negative regulation of cellular catabolic process (GO:0031330) 1/145 0.9540962 1 0 0 0.3291910 0.0154689 TNNI3
1514 purine-containing compound biosynthetic process (GO:0072522) 1/146 0.9550649 1 0 0 0.3269363 0.0150312 SLC26A2
1515 protein homooligomerization (GO:0051260) 2/230 0.9553831 1 0 0 0.4150669 0.0189449 C1QTNF1;SLC6A1
1516 regulation of establishment of protein localization (GO:0070201) 5/442 0.9564577 1 0 0 0.5399626 0.0240385 CSF3;CHRM1;PTGS2;ALOX15B;STXBP5L
1517 lipid catabolic process (GO:0016042) 2/232 0.9569409 1 0 0 0.4114888 0.0181111 LIPG;APOB
1518 regulation of proteolysis involved in cellular protein catabolic process (GO:1903050) 1/148 0.9569415 1 0 0 0.3225182 0.0141950 NEK6
1519 regulation of JNK cascade (GO:0046328) 1/148 0.9569415 1 0 0 0.3225182 0.0141950 WNT16
1520 regulation of cell-substrate adhesion (GO:0010810) 1/149 0.9578502 1 0 0 0.3203537 0.0137957 THBS1
1521 positive regulation of Rho GTPase activity (GO:0032321) 1/149 0.9578502 1 0 0 0.3203537 0.0137957 CCL24
1522 regulation of cell division (GO:0051302) 2/234 0.9584467 1 0 0 0.4079718 0.0173149 NEK6;NKX3-1
1523 Wnt signaling pathway (GO:0016055) 2/234 0.9584467 1 0 0 0.4079718 0.0173149 WNT16;CTHRC1
1524 negative regulation of cell growth (GO:0030308) 1/150 0.9587398 1 0 0 0.3182180 0.0134083 CGREF1
1525 single organismal cell-cell adhesion (GO:0016337) 2/235 0.9591806 1 0 0 0.4062357 0.0169302 CDSN;CEACAM5
1526 potassium ion transport (GO:0006813) 1/151 0.9596107 1 0 0 0.3161106 0.0130325 KCNN2
1527 activation of innate immune response (GO:0002218) 1/151 0.9596107 1 0 0 0.3161106 0.0130325 IRAK3
1528 negative regulation of immune system process (GO:0002683) 3/311 0.9600120 1 0 0 0.4604440 0.0187905 ZBTB16;IRAK3;THBS1
1529 peptidyl-tyrosine phosphorylation (GO:0018108) 1/152 0.9604633 1 0 0 0.3140309 0.0126679 NTRK2
1530 regulation of canonical Wnt signaling pathway (GO:0060828) 1/152 0.9604633 1 0 0 0.3140309 0.0126679 CTHRC1
1531 maintenance of location (GO:0051235) 1/152 0.9604633 1 0 0 0.3140309 0.0126679 FBN2
1532 receptor-mediated endocytosis (GO:0006898) 1/152 0.9604633 1 0 0 0.3140309 0.0126679 APOB
1533 muscle system process (GO:0003012) 2/237 0.9606113 1 0 0 0.4028076 0.0161870 EDN2;TNNI3
1534 regulation of homeostatic process (GO:0032844) 3/314 0.9618780 1 0 0 0.4560449 0.0177254 BMP8A;PTGS2;ADRA2A
1535 negative regulation of cell development (GO:0010721) 2/239 0.9619939 1 0 0 0.3994368 0.0154771 SIX3;PAX6
1536 peptidyl-tyrosine modification (GO:0018212) 1/154 0.9621149 1 0 0 0.3099526 0.0119708 NTRK2
1537 positive regulation of protein processing (GO:0010954) 2/240 0.9626676 1 0 0 0.3977725 0.0151341 ADRA2A;NKX3-1
1538 positive regulation of protein maturation (GO:1903319) 2/240 0.9626676 1 0 0 0.3977725 0.0151341 ADRA2A;NKX3-1
1539 mitotic nuclear division (GO:0007067) 2/240 0.9626676 1 0 0 0.3977725 0.0151341 NEK6;FIGN
1540 regulation of cellular protein catabolic process (GO:1903362) 1/155 0.9629147 1 0 0 0.3079529 0.0116377 NEK6
1541 cell cycle checkpoint (GO:0000075) 1/156 0.9636976 1 0 0 0.3059788 0.0113144 NEK6
1542 regulation of myeloid cell differentiation (GO:0045637) 1/156 0.9636976 1 0 0 0.3059788 0.0113144 ZBTB16
1543 negative regulation of phosphorus metabolic process (GO:0010563) 5/458 0.9649916 1 0 0 0.5210993 0.0185698 AHSG;GRM8;TNNI3;IRAK3;ADRA2A
1544 negative regulation of phosphate metabolic process (GO:0045936) 5/458 0.9649916 1 0 0 0.5210993 0.0185698 AHSG;GRM8;TNNI3;IRAK3;ADRA2A
1545 regulation of mitotic cell cycle (GO:0007346) 4/391 0.9654132 1 0 0 0.4883140 0.0171882 MUC1;BRINP1;NEK6;NKX3-1
1546 cellular response to hormone stimulus (GO:0032870) 5/462 0.9668704 1 0 0 0.5165876 0.0174043 STC1;APOB;ADRA2A;NKX3-1;CYP17A1
1547 small molecule biosynthetic process (GO:0044283) 4/394 0.9669123 1 0 0 0.4845959 0.0163054 EDN2;PYCR1;PTGS2;ALOX15B
1548 regulation of intracellular transport (GO:0032386) 4/394 0.9669123 1 0 0 0.4845959 0.0163054 CSF3;CHRM1;ADORA3;PTGS2
1549 endocytosis (GO:0006897) 3/323 0.9669972 1 0 0 0.4433377 0.0148783 AHSG;ELMOD1;APOB
1550 protein dephosphorylation (GO:0006470) 1/161 0.9673719 1 0 0 0.2964764 0.0098348 PTPRH
1551 cell-cell junction organization (GO:0045216) 1/161 0.9673719 1 0 0 0.2964764 0.0098348 CDH15
1552 regulation of cell morphogenesis involved in differentiation (GO:0010769) 2/248 0.9676601 1 0 0 0.3849411 0.0126547 NTRK2;CUX2
1553 morphogenesis of a branching epithelium (GO:0061138) 1/162 0.9680609 1 0 0 0.2946463 0.0095643 NKX3-1
1554 glycosaminoglycan metabolic process (GO:0030203) 1/162 0.9680609 1 0 0 0.2946463 0.0095643 SLC26A2
1555 developmental growth (GO:0048589) 1/163 0.9687355 1 0 0 0.2928386 0.0093016 PTHLH
1556 response to virus (GO:0009615) 2/250 0.9688041 1 0 0 0.3818616 0.0121023 IRAK3;APOB
1557 regulation of mitotic cell cycle phase transition (GO:1901990) 2/251 0.9693615 1 0 0 0.3803402 0.0118353 MUC1;NEK6
1558 rhythmic process (GO:0048511) 2/252 0.9699092 1 0 0 0.3788309 0.0115744 NTRK2;SIX3
1559 activation of protein kinase activity (GO:0032147) 2/252 0.9699092 1 0 0 0.3788309 0.0115744 THBS1;ADRA2A
1560 cellular carbohydrate metabolic process (GO:0044262) 1/165 0.9700422 1 0 0 0.2892891 0.0087989 HKDC1
1561 regulation of endocytosis (GO:0030100) 1/165 0.9700422 1 0 0 0.2892891 0.0087989 AHSG
1562 response to transforming growth factor beta (GO:0071559) 1/166 0.9706750 1 0 0 0.2875464 0.0085584 LEFTY1
1563 cellular response to transforming growth factor beta stimulus (GO:0071560) 1/166 0.9706750 1 0 0 0.2875464 0.0085584 LEFTY1
1564 organic hydroxy compound biosynthetic process (GO:1901617) 1/166 0.9706750 1 0 0 0.2875464 0.0085584 GPR37
1565 monocarboxylic acid metabolic process (GO:0032787) 5/473 0.9715686 1 0 0 0.5045740 0.0145536 EDN2;HKDC1;SLCO1B3;PTGS2;ALOX15B
1566 organ morphogenesis (GO:0009887) 4/405 0.9719072 1 0 0 0.4714340 0.0134335 COMP;LEFTY1;CDSN;PAX6
1567 epithelium development (GO:0060429) 2/256 0.9720074 1 0 0 0.3729117 0.0105877 CDSN;PTHLH
1568 positive regulation of protein serine/threonine kinase activity (GO:0071902) 2/257 0.9725095 1 0 0 0.3714607 0.0103546 THBS1;ADRA2A
1569 organic hydroxy compound metabolic process (GO:1901615) 5/476 0.9727386 1 0 0 0.5013939 0.0138585 TPO;GPR37;SLCO1B3;APOB;CYP17A1
1570 MAPK cascade (GO:0000165) 1/170 0.9730755 1 0 0 0.2807806 0.0076635 CDC42EP5
1571 morphogenesis of a branching structure (GO:0001763) 1/170 0.9730755 1 0 0 0.2807806 0.0076635 NKX3-1
1572 regulation of stress-activated MAPK cascade (GO:0032872) 1/170 0.9730755 1 0 0 0.2807806 0.0076635 WNT16
1573 regulation of cell morphogenesis (GO:0022604) 4/408 0.9731419 1 0 0 0.4679676 0.0127406 CCL24;NTRK2;CUX2;CDC42EP5
1574 regulation of cell adhesion (GO:0030155) 3/336 0.9732599 1 0 0 0.4261848 0.0115514 ADAMDEC1;C1QTNF1;THBS1
1575 single organism cell adhesion (GO:0098602) 2/259 0.9734878 1 0 0 0.3685923 0.0099041 CDSN;CEACAM5
1576 aminoglycan metabolic process (GO:0006022) 1/171 0.9736444 1 0 0 0.2791386 0.0074556 SLC26A2
1577 regulation of stress-activated protein kinase signaling cascade (GO:0070302) 1/171 0.9736444 1 0 0 0.2791386 0.0074556 WNT16
1578 positive regulation of cell adhesion (GO:0045785) 1/171 0.9736444 1 0 0 0.2791386 0.0074556 THBS1
1579 regulation of chromosome organization (GO:0033044) 1/172 0.9742013 1 0 0 0.2775157 0.0072535 MUC1
1580 regulation of cytokine production (GO:0001817) 5/482 0.9749458 1 0 0 0.4951525 0.0125637 IRAK3;PTGS2;ALOX15B;THBS1;ADRA2A
1581 reproductive structure development (GO:0048608) 2/265 0.9762254 1 0 0 0.3602468 0.0086682 ALOX15B;NKX3-1
1582 cellular amide metabolic process (GO:0043603) 1/177 0.9768143 1 0 0 0.2696763 0.0063262 CPE
1583 negative regulation of intracellular signal transduction (GO:1902532) 3/345 0.9769175 1 0 0 0.4150669 0.0096931 MUC1;IRAK3;THBS1
1584 regulation of cellular ketone metabolic process (GO:0010565) 1/178 0.9773044 1 0 0 0.2681612 0.0061562 PTGS2
1585 regulation of cell activation (GO:0050865) 4/420 0.9775904 1 0 0 0.4545971 0.0103032 C1QTNF1;ADORA3;ZBTB16;THBS1
1586 mitochondrion organization (GO:0007005) 1/179 0.9777841 1 0 0 0.2666631 0.0059910 BHLHA15
1587 protein catabolic process (GO:0030163) 2/269 0.9778966 1 0 0 0.3548899 0.0079323 PRSS16;APOB
1588 multicellular organismal reproductive process (GO:0048609) 5/491 0.9779472 1 0 0 0.4860763 0.0108393 CATSPERB;PTGS2;APOB;FOXA3;CYP17A1
1589 locomotory behavior (GO:0007626) 1/183 0.9796038 1 0 0 0.2608344 0.0053750 PCDH15
1590 spermatogenesis (GO:0007283) 3/353 0.9797652 1 0 0 0.4056603 0.0082927 CATSPERB;APOB;FOXA3
1591 male gamete generation (GO:0048232) 3/354 0.9800967 1 0 0 0.4045144 0.0081324 CATSPERB;APOB;FOXA3
1592 regulation of neuron projection development (GO:0010975) 2/275 0.9801922 1 0 0 0.3471469 0.0069452 NTRK2;CUX2
1593 antigen processing and presentation of peptide antigen (GO:0048002) 1/185 0.9804571 1 0 0 0.2580146 0.0050923 AZGP1
1594 DNA replication (GO:0006260) 1/186 0.9808703 1 0 0 0.2566274 0.0049568 ADRA2A
1595 intracellular receptor signaling pathway (GO:0030522) 1/186 0.9808703 1 0 0 0.2566274 0.0049568 NKX3-1
1596 positive regulation of cell cycle (GO:0045787) 2/278 0.9812518 1 0 0 0.3434007 0.0064993 MUC1;NKX3-1
1597 brain development (GO:0007420) 1/187 0.9812747 1 0 0 0.2552551 0.0048250 SIX3
1598 tissue morphogenesis (GO:0048729) 3/358 0.9813716 1 0 0 0.3999947 0.0075215 PCDH15;TNNI3;NKX3-1
1599 regulation of neuron apoptotic process (GO:0043523) 1/188 0.9816707 1 0 0 0.2538973 0.0046969 NTRK2
1600 positive regulation of growth (GO:0045927) 1/189 0.9820583 1 0 0 0.2525540 0.0045724 TFCP2L1
1601 positive regulation of T cell activation (GO:0050870) 1/189 0.9820583 1 0 0 0.2525540 0.0045724 ZBTB16
1602 negative regulation of protein kinase activity (GO:0006469) 1/189 0.9820583 1 0 0 0.2525540 0.0045724 IRAK3
1603 positive regulation of innate immune response (GO:0045089) 1/190 0.9824377 1 0 0 0.2512247 0.0044513 IRAK3
1604 cellular component morphogenesis (GO:0032989) 4/437 0.9827203 1 0 0 0.4369126 0.0076157 STC1;TFCP2L1;SHROOM1;WNT16
1605 response to peptide hormone (GO:0043434) 3/364 0.9831391 1 0 0 0.3934013 0.0066897 HSD11B2;TFF1;PLAT
1606 negative regulation of mitotic cell cycle phase transition (GO:1901991) 1/192 0.9831727 1 0 0 0.2486078 0.0042190 MUC1
1607 small GTPase mediated signal transduction (GO:0007264) 4/439 0.9832450 1 0 0 0.4349221 0.0073489 RAB43;ARHGAP40;CDC42EP5;ADRA2A
1608 transmembrane receptor protein serine/threonine kinase signaling pathway (GO:0007178) 1/196 0.9845518 1 0 0 0.2435342 0.0037915 LEFTY1
1609 coenzyme metabolic process (GO:0006732) 1/196 0.9845518 1 0 0 0.2435342 0.0037915 ALDH1L2
1610 carboxylic acid catabolic process (GO:0046395) 1/200 0.9858182 1 0 0 0.2386635 0.0034089 ALDH1L2
1611 organic acid catabolic process (GO:0016054) 1/200 0.9858182 1 0 0 0.2386635 0.0034089 ALDH1L2
1612 negative regulation of cell cycle phase transition (GO:1901988) 1/200 0.9858182 1 0 0 0.2386635 0.0034089 MUC1
1613 generation of precursor metabolites and energy (GO:0006091) 3/375 0.9859716 1 0 0 0.3818616 0.0053948 HKDC1;CACNA1E;ADRA2A
1614 negative regulation of kinase activity (GO:0033673) 1/202 0.9864119 1 0 0 0.2363005 0.0032329 IRAK3
1615 signal transduction by phosphorylation (GO:0023014) 1/202 0.9864119 1 0 0 0.2363005 0.0032329 CDC42EP5
1616 morphogenesis of an epithelium (GO:0002009) 2/296 0.9865454 1 0 0 0.3225182 0.0043688 PCDH15;NKX3-1
1617 nuclear division (GO:0000280) 2/298 0.9870350 1 0 0 0.3203537 0.0041806 NEK6;FIGN
1618 response to peptide (GO:1901652) 3/384 0.9879443 1 0 0 0.3729117 0.0045230 HSD11B2;TFF1;PLAT
1619 nucleotide biosynthetic process (GO:0009165) 1/208 0.9880485 1 0 0 0.2294841 0.0027592 SLC26A2
1620 regulation of leukocyte differentiation (GO:1902105) 1/210 0.9885491 1 0 0 0.2272986 0.0026178 ZBTB16
1621 nitrogen compound transport (GO:0071705) 4/464 0.9886529 1 0 0 0.4114888 0.0046959 NTRK2;TCN1;ADORA3;SLC6A1
1622 regulation of leukocyte activation (GO:0002694) 3/390 0.9891084 1 0 0 0.3671746 0.0040210 ADORA3;ZBTB16;THBS1
1623 gamete generation (GO:0007276) 3/390 0.9891084 1 0 0 0.3671746 0.0040210 CATSPERB;APOB;FOXA3
1624 cell projection assembly (GO:0030031) 1/213 0.9892610 1 0 0 0.2240972 0.0024196 PCDH15
1625 regulation of cell projection organization (GO:0031344) 3/391 0.9892916 1 0 0 0.3662355 0.0039429 NTRK2;CUX2;CDC42EP5
1626 positive regulation of sequence-specific DNA binding transcription factor activity (GO:0051091) 1/214 0.9894884 1 0 0 0.2230500 0.0023570 IRAK3
1627 transcription from RNA polymerase II promoter (GO:0006366) 4/470 0.9896779 1 0 0 0.4062357 0.0042150 SIX3;PAX6;SPDEF;NKX3-1
1628 sulfur compound metabolic process (GO:0006790) 2/314 0.9903742 1 0 0 0.3040299 0.0029407 SULT1C2;SLC26A2
1629 positive regulation of cell cycle process (GO:0090068) 1/220 0.9907551 1 0 0 0.2169668 0.0020152 MUC1
1630 protein folding (GO:0006457) 1/221 0.9909508 1 0 0 0.2159851 0.0019634 FKBP5
1631 in utero embryonic development (GO:0001701) 1/222 0.9911425 1 0 0 0.2150121 0.0019130 APOB
1632 antigen processing and presentation (GO:0019882) 1/225 0.9916935 1 0 0 0.2121453 0.0017696 AZGP1
1633 response to light stimulus (GO:0009416) 2/322 0.9917129 1 0 0 0.2964764 0.0024672 APOB;PTGS2
1634 chordate embryonic development (GO:0043009) 1/226 0.9918694 1 0 0 0.2112066 0.0017243 APOB
1635 negative regulation of phosphorylation (GO:0042326) 2/325 0.9921666 1 0 0 0.2937397 0.0023101 AHSG;IRAK3
1636 organelle fission (GO:0048285) 2/325 0.9921666 1 0 0 0.2937397 0.0023101 NEK6;FIGN
1637 cellular process involved in reproduction in multicellular organism (GO:0022412) 1/228 0.9922102 1 0 0 0.2093539 0.0016372 ZBTB16
1638 embryo development ending in birth or egg hatching (GO:0009792) 1/230 0.9925368 1 0 0 0.2075335 0.0015547 APOB
1639 nucleic acid phosphodiester bond hydrolysis (GO:0090305) 1/230 0.9925368 1 0 0 0.2075335 0.0015547 AZGP1
1640 cellular response to abiotic stimulus (GO:0071214) 1/232 0.9928497 1 0 0 0.2057444 0.0014764 PTGS2
1641 regulation of protein serine/threonine kinase activity (GO:0071900) 3/416 0.9930174 1 0 0 0.3442262 0.0024120 IRAK3;THBS1;ADRA2A
1642 cellular amino acid metabolic process (GO:0006520) 3/421 0.9935946 1 0 0 0.3401380 0.0021857 TPO;PYCR1;ALDH1L2
1643 regulation of sequence-specific DNA binding transcription factor activity (GO:0051090) 2/338 0.9938674 1 0 0 0.2824420 0.0017374 IRAK3;PTHLH
1644 alcohol metabolic process (GO:0006066) 2/340 0.9940947 1 0 0 0.2807806 0.0016630 APOB;CYP17A1
1645 GTP catabolic process (GO:0006184) 1/243 0.9943507 1 0 0 0.1964309 0.0011129 RAB43
1646 positive regulation of lymphocyte activation (GO:0051251) 1/243 0.9943507 1 0 0 0.1964309 0.0011129 ZBTB16
1647 microtubule cytoskeleton organization (GO:0000226) 1/245 0.9945876 1 0 0 0.1948273 0.0010573 NEK6
1648 guanosine-containing compound catabolic process (GO:1901069) 1/246 0.9947024 1 0 0 0.1940354 0.0010307 RAB43
1649 response to insulin (GO:0032868) 1/246 0.9947024 1 0 0 0.1940354 0.0010307 HSD11B2
1650 regulation of Ras GTPase activity (GO:0032318) 2/349 0.9950197 1 0 0 0.2735398 0.0013657 CCL24;NTRK2
1651 cellular component disassembly (GO:0022411) 2/350 0.9951133 1 0 0 0.2727583 0.0013362 FBN2;NEK6
1652 leukocyte differentiation (GO:0002521) 1/251 0.9952406 1 0 0 0.1901701 0.0009072 CSF3
1653 inorganic cation transmembrane transport (GO:0098662) 3/440 0.9953955 1 0 0 0.3254502 0.0015020 JPH2;KCNN2;CACNA1E
1654 regulation of innate immune response (GO:0045088) 1/254 0.9955370 1 0 0 0.1879240 0.0008406 IRAK3
1655 negative regulation of cell cycle process (GO:0010948) 1/254 0.9955370 1 0 0 0.1879240 0.0008406 MUC1
1656 response to radiation (GO:0009314) 3/442 0.9955537 1 0 0 0.3239776 0.0014437 PTGS2;APOB;CYP17A1
1657 cofactor metabolic process (GO:0051186) 1/255 0.9956317 1 0 0 0.1871870 0.0008195 ALDH1L2
1658 regulation of small GTPase mediated signal transduction (GO:0051056) 1/256 0.9957243 1 0 0 0.1864558 0.0007989 ARHGAP40
1659 GTP metabolic process (GO:0046039) 1/258 0.9959038 1 0 0 0.1850105 0.0007594 RAB43
1660 regulation of T cell activation (GO:0050863) 1/259 0.9959906 1 0 0 0.1842961 0.0007404 ZBTB16
1661 negative regulation of protein phosphorylation (GO:0001933) 1/260 0.9960757 1 0 0 0.1835873 0.0007219 IRAK3
1662 small molecule catabolic process (GO:0044282) 1/261 0.9961589 1 0 0 0.1828839 0.0007038 ALDH1L2
1663 protein oligomerization (GO:0051259) 2/366 0.9963958 1 0 0 0.2608344 0.0009418 C1QTNF1;SLC6A1
1664 regulation of translation (GO:0006417) 1/264 0.9963982 1 0 0 0.1808057 0.0006524 THBS1
1665 positive regulation of protein kinase activity (GO:0045860) 3/456 0.9965219 1 0 0 0.3140309 0.0010941 THBS1;ADRA2A;NKX3-1
1666 methylation (GO:0032259) 1/269 0.9967644 1 0 0 0.1774450 0.0005751 ALDH1L2
1667 guanosine-containing compound metabolic process (GO:1901068) 1/269 0.9967644 1 0 0 0.1774450 0.0005751 RAB43
1668 carbohydrate derivative biosynthetic process (GO:1901137) 2/377 0.9970793 1 0 0 0.2532239 0.0007407 SLC26A2;B3GNT6
1669 neurotrophin TRK receptor signaling pathway (GO:0048011) 1/274 0.9970934 1 0 0 0.1742069 0.0005071 NTRK2
1670 embryo development (GO:0009790) 1/276 0.9972154 1 0 0 0.1729446 0.0004822 APOB
1671 protein localization to membrane (GO:0072657) 1/276 0.9972154 1 0 0 0.1729446 0.0004822 CPE
1672 neurotrophin signaling pathway (GO:0038179) 1/278 0.9973324 1 0 0 0.1717003 0.0004586 NTRK2
1673 dephosphorylation (GO:0016311) 1/278 0.9973324 1 0 0 0.1717003 0.0004586 PTPRH
1674 monovalent inorganic cation transport (GO:0015672) 2/384 0.9974461 1 0 0 0.2486078 0.0006357 KCNN2;SLC13A5
1675 negative regulation of transferase activity (GO:0051348) 1/284 0.9976546 1 0 0 0.1680729 0.0003947 IRAK3
1676 positive regulation of kinase activity (GO:0033674) 3/480 0.9977258 1 0 0 0.2983294 0.0006792 THBS1;ADRA2A;NKX3-1
1677 regulation of cell cycle process (GO:0010564) 3/481 0.9977659 1 0 0 0.2977091 0.0006658 MUC1;NEK6;SIX3
1678 positive regulation of GTPase activity (GO:0043547) 3/482 0.9978054 1 0 0 0.2970915 0.0006527 CCL24;ARHGAP40;ELMOD1
1679 positive regulation of GTP catabolic process (GO:0033126) 3/483 0.9978441 1 0 0 0.2964764 0.0006399 CCL24;ARHGAP40;ELMOD1
1680 phospholipid metabolic process (GO:0006644) 1/288 0.9978475 1 0 0 0.1657385 0.0003571 LIPG
1681 protein localization to organelle (GO:0033365) 2/396 0.9979723 1 0 0 0.2410742 0.0004893 ZBTB16;PAX6
1682 positive regulation of Ras GTPase activity (GO:0032320) 1/292 0.9980245 1 0 0 0.1634681 0.0003233 CCL24
1683 glycerolipid metabolic process (GO:0046486) 1/296 0.9981870 1 0 0 0.1612591 0.0002926 APOB
1684 cellular response to organonitrogen compound (GO:0071417) 2/411 0.9984821 1 0 0 0.2322759 0.0003528 STC1;PTGS2
1685 regulation of multi-organism process (GO:0043900) 1/306 0.9985371 1 0 0 0.1559892 0.0002284 PLAT
1686 nucleoside monophosphate metabolic process (GO:0009123) 2/427 0.9988868 1 0 0 0.2235724 0.0002490 RTEL1-TNFRSF6B;ENTPD8
1687 regulation of cell growth (GO:0001558) 1/322 0.9989623 1 0 0 0.1482382 0.0001539 CGREF1
1688 organophosphate biosynthetic process (GO:0090407) 2/436 0.9990655 1 0 0 0.2189573 0.0002047 SLC26A2;ENTPD8
1689 ATP catabolic process (GO:0006200) 1/327 0.9990679 1 0 0 0.1459716 0.0001361 RTEL1-TNFRSF6B
1690 cellular response to nitrogen compound (GO:1901699) 2/438 0.9991012 1 0 0 0.2179575 0.0001960 STC1;PTGS2
1691 purine ribonucleoside monophosphate catabolic process (GO:0009169) 1/332 0.9991627 1 0 0 0.1437732 0.0001204 RTEL1-TNFRSF6B
1692 ribonucleoside monophosphate catabolic process (GO:0009158) 1/332 0.9991627 1 0 0 0.1437732 0.0001204 RTEL1-TNFRSF6B
1693 purine nucleoside monophosphate catabolic process (GO:0009128) 1/333 0.9991805 1 0 0 0.1433414 0.0001175 RTEL1-TNFRSF6B
1694 nucleoside monophosphate catabolic process (GO:0009125) 1/335 0.9992149 1 0 0 0.1424857 0.0001119 RTEL1-TNFRSF6B
1695 regulation of lymphocyte activation (GO:0051249) 1/344 0.9993527 1 0 0 0.1387578 0.0000898 ZBTB16
1696 response to other organism (GO:0051707) 2/462 0.9994372 1 0 0 0.2066351 0.0001163 IRAK3;APOB
1697 negative regulation of cellular component organization (GO:0051129) 2/474 0.9995549 1 0 0 0.2014038 0.0000897 IRAK3;THBS1
1698 leukocyte activation (GO:0045321) 1/373 0.9996522 1 0 0 0.1279697 0.0000445 EDN2
1699 ATP metabolic process (GO:0046034) 1/377 0.9996807 1 0 0 0.1266119 0.0000404 RTEL1-TNFRSF6B
1700 single-organism cellular localization (GO:1902580) 2/496 0.9997107 1 0 0 0.1924706 0.0000557 CPE;BHLHA15
1701 purine ribonucleoside monophosphate metabolic process (GO:0009167) 1/402 0.9998126 1 0 0 0.1187381 0.0000223 RTEL1-TNFRSF6B
1702 purine nucleoside monophosphate metabolic process (GO:0009126) 1/403 0.9998165 1 0 0 0.1184434 0.0000217 RTEL1-TNFRSF6B
1703 mitotic cell cycle (GO:0000278) 1/404 0.9998204 1 0 0 0.1181502 0.0000212 NEK6
1704 negative regulation of protein modification process (GO:0031400) 1/407 0.9998314 1 0 0 0.1172794 0.0000198 IRAK3
1705 ribonucleoside monophosphate metabolic process (GO:0009161) 1/416 0.9998607 1 0 0 0.1147421 0.0000160 RTEL1-TNFRSF6B
1706 microtubule-based process (GO:0007017) 1/437 0.9999103 1 0 0 0.1092281 0.0000098 NEK6
1707 posttranscriptional regulation of gene expression (GO:0010608) 1/438 0.9999122 1 0 0 0.1089788 0.0000096 THBS1
1708 immune response-activating signal transduction (GO:0002757) 1/440 0.9999158 1 0 0 0.1084834 0.0000091 IRAK3
1709 detection of chemical stimulus involved in sensory perception (GO:0050907) 1/465 0.9999496 1 0 0 0.1026510 0.0000052 AZGP1
1710 chromatin modification (GO:0016568) 1/475 0.9999588 1 0 0 0.1004899 0.0000041 FOXA3
1711 activation of immune response (GO:0002253) 1/487 0.9999674 1 0 0 0.0980138 0.0000032 IRAK3
1712 detection of chemical stimulus (GO:0009593) 1/499 0.9999741 1 0 0 0.0956567 0.0000025 AZGP1

GO_Cellular_Component_2015

go_cellular %>%
  knitr::kable(
    format = "html", align = rep("c", ncol(go_cellular) + 1),
    row.names = TRUE
  ) %>%
  kableExtra::kable_styling() %>%
  kableExtra::scroll_box(height = "300px")
Term Overlap P.value Adjusted.P.value Old.P.value Old.Adjusted.P.value Odds.Ratio Combined.Score Genes
1 fibril (GO:0043205) 2/13 0.0293193 1 0 0 7.3434918 25.9189276 FBN2;MUC5AC
2 extracellular space (GO:0005615) 32/1120 0.0469779 1 0 0 1.3637913 4.1705816 CSF3;PCDH15;STC1;PLAT;MSLN;CXCL2;THBS1;PTHLH;COMP;TPO;MUC1;C1QTNF1;LIPG;APOB;CTHRC1;SERPINB4;CCL24;LEFTY1;EDN2;AHSG;BMP8A;IL19;WNT16;F5;AZGP1;TCN1;PXDN;HMSD;LCN2;SSPO;TFF1;PKHD1L1
3 Golgi lumen (GO:0005796) 4/86 0.1065052 1 0 0 2.2201254 4.9721080 MUC1;MUC3A;MUC5AC;MUC6
4 troponin complex (GO:0005861) 1/8 0.1558373 1 0 0 5.9665871 11.0915436 TNNI3
5 fibrinogen complex (GO:0005577) 1/8 0.1558373 1 0 0 5.9665871 11.0915436 THBS1
6 asymmetric synapse (GO:0032279) 1/8 0.1558373 1 0 0 5.9665871 11.0915436 CHRM1
7 microfibril (GO:0001527) 1/9 0.1735296 1 0 0 5.3036330 9.2888214 FBN2
8 CatSper complex (GO:0036128) 1/9 0.1735296 1 0 0 5.3036330 9.2888214 CATSPERB
9 voltage-gated calcium channel complex (GO:0005891) 2/38 0.1889323 1 0 0 2.5122472 4.1863248 CATSPERB;CACNA1E
10 junctional sarcoplasmic reticulum membrane (GO:0014701) 1/10 0.1908519 1 0 0 4.7732697 7.9057641 JPH2
11 vesicle lumen (GO:0031983) 3/76 0.2132832 1 0 0 1.8841854 2.9113198 APOB;THBS1;F5
12 cytoplasmic membrane-bounded vesicle lumen (GO:0060205) 3/76 0.2132832 1 0 0 1.8841854 2.9113198 APOB;THBS1;F5
13 endosome lumen (GO:0031904) 1/12 0.2244175 1 0 0 3.9777247 5.9437046 APOB
14 chylomicron (GO:0042627) 1/13 0.2406756 1 0 0 3.6717459 5.2296866 APOB
15 MHC class I protein complex (GO:0042612) 1/13 0.2406756 1 0 0 3.6717459 5.2296866 AZGP1
16 platelet alpha granule (GO:0031091) 1/13 0.2406756 1 0 0 3.6717459 5.2296866 THBS1
17 Golgi cisterna membrane (GO:0032580) 1/14 0.2565938 1 0 0 3.4094783 4.6377803 FUT6
18 low-density lipoprotein particle (GO:0034362) 1/14 0.2565938 1 0 0 3.4094783 4.6377803 APOB
19 smooth endoplasmic reticulum (GO:0005790) 1/14 0.2565938 1 0 0 3.4094783 4.6377803 KCNN2
20 platelet alpha granule lumen (GO:0031093) 2/48 0.2663018 1 0 0 1.9888624 2.6315136 THBS1;F5
21 extracellular matrix part (GO:0044420) 4/127 0.2761944 1 0 0 1.5033920 1.9343398 FBN2;ENTPD2;NID2;MUC5AC
22 basal lamina (GO:0005605) 1/16 0.2874383 1 0 0 2.9832936 3.7194122 ENTPD2
23 endocytic vesicle lumen (GO:0071682) 1/16 0.2874383 1 0 0 2.9832936 3.7194122 APOB
24 extracellular matrix (GO:0031012) 9/348 0.3076000 1 0 0 1.2344663 1.4553804 COMP;FBN2;PXDN;CHAD;PLAT;WNT16;NID2;THBS1;CTHRC1
25 neuronal postsynaptic density (GO:0097481) 1/18 0.3170060 1 0 0 2.6518165 3.0464985 NTRK2
26 mast cell granule (GO:0042629) 1/18 0.3170060 1 0 0 2.6518165 3.0464985 ADORA3
27 desmosome (GO:0030057) 1/19 0.3313276 1 0 0 2.5122472 2.7751481 CDSN
28 excitatory synapse (GO:0060076) 1/19 0.3313276 1 0 0 2.5122472 2.7751481 NTRK2
29 stereocilium (GO:0032420) 1/19 0.3313276 1 0 0 2.5122472 2.7751481 PCDH15
30 calcium channel complex (GO:0034704) 2/57 0.3360828 1 0 0 1.6748315 1.8262323 CATSPERB;CACNA1E
31 very-low-density lipoprotein particle (GO:0034361) 1/20 0.3453496 1 0 0 2.3866348 2.5374656 APOB
32 triglyceride-rich lipoprotein particle (GO:0034385) 1/20 0.3453496 1 0 0 2.3866348 2.5374656 APOB
33 costamere (GO:0043034) 1/21 0.3590782 1 0 0 2.2729856 2.3280260 FLNC
34 secretory granule lumen (GO:0034774) 2/62 0.3740573 1 0 0 1.5397644 1.5141217 THBS1;F5
35 proteinaceous extracellular matrix (GO:0005578) 6/239 0.3852649 1 0 0 1.1983104 1.1429775 COMP;FBN2;PXDN;CHAD;WNT16;CTHRC1
36 cornified envelope (GO:0001533) 1/23 0.3856798 1 0 0 2.0753346 1.9772706 CDSN
37 sarcoplasmic reticulum membrane (GO:0033017) 1/23 0.3856798 1 0 0 2.0753346 1.9772706 JPH2
38 synapse (GO:0045202) 6/243 0.4002119 1 0 0 1.1785851 1.0793025 NTRK2;CHRM1;PCDH15;PLAT;CDH15;ADRA2A
39 presynaptic active zone (GO:0048786) 1/25 0.4111798 1 0 0 1.9093079 1.6968492 NTRK2
40 myosin II complex (GO:0016460) 1/25 0.4111798 1 0 0 1.9093079 1.6968492 SHROOM1
41 dendritic spine (GO:0043197) 2/71 0.4399794 1 0 0 1.3445830 1.1039396 NTRK2;KCNN2
42 MHC protein complex (GO:0042611) 1/29 0.4590552 1 0 0 1.6459551 1.2815157 AZGP1
43 neuron spine (GO:0044309) 2/74 0.4611076 1 0 0 1.2900729 0.9986763 NTRK2;KCNN2
44 contractile fiber part (GO:0044449) 4/167 0.4646495 1 0 0 1.1432981 0.8763060 JPH2;KCNN2;TNNI3;FLNC
45 clathrin-coated endocytic vesicle membrane (GO:0030669) 1/31 0.4815161 1 0 0 1.5397644 1.1252839 APOB
46 integrin complex (GO:0008305) 1/31 0.4815161 1 0 0 1.5397644 1.1252839 ITGA10
47 sarcomere (GO:0030017) 1/31 0.4815161 1 0 0 1.5397644 1.1252839 TNNI3
48 protein complex involved in cell adhesion (GO:0098636) 1/31 0.4815161 1 0 0 1.5397644 1.1252839 ITGA10
49 photoreceptor outer segment (GO:0001750) 1/34 0.5134749 1 0 0 1.4039028 0.9357774 PCDH15
50 axon terminus (GO:0043679) 1/34 0.5134749 1 0 0 1.4039028 0.9357774 CHRM1
51 SNARE complex (GO:0031201) 1/35 0.5236849 1 0 0 1.3637913 0.8821891 DOC2B
52 T-tubule (GO:0030315) 1/36 0.5336812 1 0 0 1.3259082 0.8326130 KCNN2
53 synaptic vesicle (GO:0008021) 2/86 0.5406975 1 0 0 1.1100627 0.6825724 DOC2B;SYT8
54 Z disc (GO:0030018) 2/87 0.5469535 1 0 0 1.0973034 0.6621035 JPH2;KCNN2
55 plasma lipoprotein particle (GO:0034358) 1/38 0.5530502 1 0 0 1.2561236 0.7440102 APOB
56 basolateral plasma membrane (GO:0016323) 3/138 0.5548702 1 0 0 1.0376673 0.6112080 CEACAM5;SLC13A5;ADRA2A
57 terminal bouton (GO:0043195) 1/39 0.5624316 1 0 0 1.2239153 0.7043459 NTRK2
58 collagen trimer (GO:0005581) 2/91 0.5713775 1 0 0 1.0490703 0.5871700 C1QTNF1;CTHRC1
59 protein-lipid complex (GO:0032994) 1/40 0.5716165 1 0 0 1.1933174 0.6674069 APOB
60 sarcoplasmic reticulum (GO:0016529) 1/40 0.5716165 1 0 0 1.1933174 0.6674069 THBS1
61 presynaptic membrane (GO:0042734) 1/44 0.6064726 1 0 0 1.0848340 0.5425209 GRM8
62 phagocytic vesicle (GO:0045335) 1/44 0.6064726 1 0 0 1.0848340 0.5425209 RAB43
63 neuron projection terminus (GO:0044306) 1/44 0.6064726 1 0 0 1.0848340 0.5425209 CHRM1
64 postsynaptic density (GO:0014069) 2/98 0.6117869 1 0 0 0.9741367 0.4786628 NTRK2;CHRM1
65 neuromuscular junction (GO:0031594) 1/47 0.6307446 1 0 0 1.0155893 0.4680387 CDH15
66 clathrin-coated vesicle membrane (GO:0030665) 1/48 0.6384987 1 0 0 0.9944312 0.4461373 APOB
67 chloride channel complex (GO:0034707) 1/50 0.6535229 1 0 0 0.9546539 0.4060885 ANO1
68 axon (GO:0030424) 3/161 0.6589222 1 0 0 0.8894291 0.3710251 OMP;SLC6A1;CYP17A1
69 secretory granule membrane (GO:0030667) 1/54 0.6817282 1 0 0 0.8839388 0.3386584 CPE
70 plasma membrane raft (GO:0044853) 1/58 0.7076424 1 0 0 0.8229775 0.2845991 CDH15
71 caveola (GO:0005901) 1/58 0.7076424 1 0 0 0.8229775 0.2845991 CDH15
72 recycling endosome (GO:0055037) 1/60 0.7197990 1 0 0 0.7955449 0.2615619 REP15
73 plasma membrane region (GO:0098590) 7/395 0.7243853 1 0 0 0.8458959 0.2727438 ANO1;MUC1;CEACAM5;STC1;CDH15;SLC13A5;ADRA2A
74 microvillus (GO:0005902) 1/61 0.7256868 1 0 0 0.7825032 0.2508993 PCDH15
75 sarcolemma (GO:0042383) 1/63 0.7370948 1 0 0 0.7576619 0.2311162 FLNC
76 myosin complex (GO:0016459) 1/64 0.7426200 1 0 0 0.7458234 0.2219352 SHROOM1
77 nuclear matrix (GO:0016363) 1/64 0.7426200 1 0 0 0.7458234 0.2219352 FIGN
78 extracellular region (GO:0005576) 30/1585 0.7466204 1 0 0 0.9034580 0.2639889 FBN2;ADAMDEC1;CSF3;PLAT;NID2;CXCL2;THBS1;ABO;PTHLH;COMP;LIPG;CREG2;APOB;MUC6;SERPINB4;CGREF1;EDN2;AHSG;IL1R2;REG4;IL19;WNT16;MUC3A;F5;AZGP1;TCN1;ADM2;BPIFB6;LCN2;KCP
79 coated vesicle membrane (GO:0030662) 1/66 0.7533254 1 0 0 0.7232227 0.2048586 APOB
80 nonmotile primary cilium (GO:0031513) 1/67 0.7585103 1 0 0 0.7124283 0.1969144 PCDH15
81 PML body (GO:0016605) 1/68 0.7635865 1 0 0 0.7019514 0.1893366 ZBTB16
82 axon part (GO:0033267) 2/133 0.7708418 1 0 0 0.7177849 0.1868194 NTRK2;CHRM1
83 transcriptional repressor complex (GO:0017053) 1/70 0.7734217 1 0 0 0.6818957 0.1752000 ZBTB16
84 apical plasma membrane (GO:0016324) 3/201 0.7957327 1 0 0 0.7124283 0.1627841 ANO1;MUC1;STC1
85 basement membrane (GO:0005604) 1/77 0.8047394 1 0 0 0.6199052 0.1346662 NID2
86 cell surface (GO:0009986) 7/437 0.8128618 1 0 0 0.7645970 0.1584201 NTRK2;MUC1;PLAT;SLC6A1;MSLN;NID2;THBS1
87 cation channel complex (GO:0034703) 2/147 0.8166169 1 0 0 0.6494244 0.1315638 CATSPERB;CACNA1E
88 neuronal cell body (GO:0043025) 4/270 0.8202560 1 0 0 0.7071511 0.1401141 NTRK2;OMP;KCNN2;CYP17A1
89 receptor complex (GO:0043235) 4/272 0.8246228 1 0 0 0.7019514 0.1353567 NTRK2;GPR37;ITGA10;ADRA2A
90 anchored component of membrane (GO:0031225) 2/150 0.8252959 1 0 0 0.6364360 0.1222042 CEACAM5;MSLN
91 nuclear speck (GO:0016607) 1/84 0.8317373 1 0 0 0.5682464 0.1046930 ZBTB16
92 apical part of cell (GO:0045177) 1/87 0.8421357 1 0 0 0.5486517 0.0942661 PLAT
93 synaptic membrane (GO:0097060) 3/228 0.8595501 1 0 0 0.6280618 0.0950547 NTRK2;CHRM1;GRM8
94 endocytic vesicle membrane (GO:0030666) 1/94 0.8639732 1 0 0 0.5077946 0.0742465 APOB
95 endocytic vesicle (GO:0030139) 1/96 0.8696394 1 0 0 0.4972156 0.0694494 RAB43
96 primary cilium (GO:0072372) 1/99 0.8777003 1 0 0 0.4821485 0.0628963 PCDH15
97 growth cone (GO:0030426) 1/99 0.8777003 1 0 0 0.4821485 0.0628963 NTRK2
98 endosome membrane (GO:0010008) 2/175 0.8843850 1 0 0 0.5455165 0.0670237 REP15;APOB
99 site of polarized growth (GO:0030427) 1/102 0.8852638 1 0 0 0.4679676 0.0570310 NTRK2
100 secretory granule (GO:0030141) 2/176 0.8863125 1 0 0 0.5424170 0.0654620 PLAT;THBS1
101 nuclear chromatin (GO:0000790) 2/177 0.8882102 1 0 0 0.5393525 0.0639385 MUC1;PAX6
102 cell body (GO:0044297) 4/315 0.8991009 1 0 0 0.6061295 0.0644679 NTRK2;OMP;KCNN2;CYP17A1
103 peroxisome (GO:0005777) 1/109 0.9011464 1 0 0 0.4379147 0.0455814 SERHL2
104 ion channel complex (GO:0034702) 3/258 0.9093509 1 0 0 0.5550314 0.0527414 ANO1;CATSPERB;CACNA1E
105 endoplasmic reticulum membrane (GO:0005789) 6/449 0.9116705 1 0 0 0.6378534 0.0589866 JPH2;PTGS2;APOB;CYP3A5;FKBP5;CYP17A1
106 external side of plasma membrane (GO:0009897) 2/191 0.9118692 1 0 0 0.4998188 0.0461126 ANO1;THBS1
107 extrinsic component of membrane (GO:0019898) 1/115 0.9130018 1 0 0 0.4150669 0.0377783 ALOX15B
108 actin cytoskeleton (GO:0015629) 2/193 0.9148392 1 0 0 0.4946393 0.0440263 APOB;MYLK3
109 postsynaptic membrane (GO:0045211) 2/195 0.9177153 1 0 0 0.4895661 0.0420381 NTRK2;CHRM1
110 synapse part (GO:0044456) 5/395 0.9193926 1 0 0 0.6042114 0.0507791 NTRK2;CHRM1;GRM8;DOC2B;SYT8
111 endosomal part (GO:0044440) 2/200 0.9245113 1 0 0 0.4773270 0.0374654 REP15;APOB
112 microbody (GO:0042579) 1/123 0.9266318 1 0 0 0.3880707 0.0295706 SERHL2
113 transmembrane transporter complex (GO:1902495) 3/286 0.9407943 1 0 0 0.5006926 0.0305576 ANO1;CATSPERB;CACNA1E
114 transporter complex (GO:1990351) 3/291 0.9452165 1 0 0 0.4920897 0.0277250 ANO1;CATSPERB;CACNA1E
115 cytoplasmic membrane-bounded vesicle (GO:0016023) 6/492 0.9475602 1 0 0 0.5821061 0.0313550 RAB43;SERHL2;PLAT;DOC2B;SYT8;THBS1
116 cytoplasmic vesicle part (GO:0044433) 4/363 0.9480627 1 0 0 0.5259801 0.0280530 CPE;APOB;THBS1;F5
117 early endosome (GO:0005769) 1/141 0.9500087 1 0 0 0.3385298 0.0173612 APOB
118 cytoplasmic vesicle membrane (GO:0030659) 2/229 0.9545841 1 0 0 0.4168794 0.0193764 CPE;APOB
119 side of membrane (GO:0098552) 2/235 0.9591806 1 0 0 0.4062357 0.0169302 ANO1;THBS1
120 endoplasmic reticulum lumen (GO:0005788) 1/154 0.9621149 1 0 0 0.3099526 0.0119708 APOB
121 cilium (GO:0005929) 2/243 0.9646208 1 0 0 0.3928617 0.0141510 CATSPERB;PCDH15
122 blood microparticle (GO:0072562) 1/161 0.9673719 1 0 0 0.2964764 0.0098348 AHSG
123 vesicle membrane (GO:0012506) 2/249 0.9682370 1 0 0 0.3833952 0.0123754 CPE;APOB
124 lysosome (GO:0005764) 2/261 0.9744325 1 0 0 0.3657678 0.0094734 ADORA3;PRSS16
125 lytic vacuole (GO:0000323) 2/261 0.9744325 1 0 0 0.3657678 0.0094734 ADORA3;PRSS16
126 Golgi apparatus (GO:0005794) 11/865 0.9750118 1 0 0 0.6070054 0.0153607 RAB43;GOLGA7B;FUT6;GOLGA6B;CREG2;CPE;MSLN;APOB;ABO;JAKMIP3;PTHLH
127 ubiquitin ligase complex (GO:0000151) 1/183 0.9796038 1 0 0 0.2608344 0.0053750 GPR37
128 integral component of plasma membrane (GO:0005887) 14/1066 0.9798480 1 0 0 0.6268834 0.0127620 NTRK2;SLC26A2;GPR37;CHRM1;SLC6A1;PTPRH;ADRA2A;TPO;MUC1;C1QTNF1;ADORA3;CEACAM5;SLCO1B3;GRM8
129 microtubule (GO:0005874) 3/360 0.9819795 1 0 0 0.3977725 0.0072334 NEK6;FIGN;SHROOM1
130 chromatin (GO:0000785) 2/289 0.9846866 1 0 0 0.3303301 0.0050976 MUC1;PAX6
131 vacuole (GO:0005773) 2/293 0.9857773 1 0 0 0.3258205 0.0046673 ADORA3;PRSS16
132 membrane raft (GO:0045121) 1/200 0.9858182 1 0 0 0.2386635 0.0034089 CDH15
133 mitochondrial matrix (GO:0005759) 1/208 0.9880485 1 0 0 0.2294841 0.0027592 PYCR1
134 nuclear body (GO:0016604) 1/210 0.9885491 1 0 0 0.2272986 0.0026178 ZBTB16
135 Golgi membrane (GO:0000139) 2/308 0.9892340 1 0 0 0.3099526 0.0033550 FUT6;B3GNT6
136 nuclear chromosome part (GO:0044454) 2/327 0.9924554 1 0 0 0.2919431 0.0022109 MUC1;PAX6
137 dendrite (GO:0030425) 1/236 0.9934367 1 0 0 0.2022572 0.0013318 CHRM1
138 mitochondrial inner membrane (GO:0005743) 2/341 0.9942053 1 0 0 0.2799572 0.0016270 SLC25A48;SLC25A18
139 organelle inner membrane (GO:0019866) 2/360 0.9959591 1 0 0 0.2651816 0.0010737 SLC25A48;SLC25A18
140 anchoring junction (GO:0070161) 2/419 0.9986999 1 0 0 0.2278410 0.0002964 CDSN;FLNC
141 cell-cell junction (GO:0005911) 1/335 0.9992149 1 0 0 0.1424857 0.0001119 CDSN
142 mitochondrial membrane (GO:0031966) 2/457 0.9993794 1 0 0 0.2088958 0.0001297 SLC25A48;SLC25A18
143 focal adhesion (GO:0005925) 1/352 0.9994547 1 0 0 0.1356043 0.0000740 FLNC
144 cell-substrate adherens junction (GO:0005924) 1/358 0.9995205 1 0 0 0.1333316 0.0000639 FLNC
145 cell-substrate junction (GO:0030055) 1/362 0.9995599 1 0 0 0.1318583 0.0000580 FLNC
146 adherens junction (GO:0005912) 1/405 0.9998241 1 0 0 0.1178585 0.0000207 FLNC
147 perinuclear region of cytoplasm (GO:0048471) 1/411 0.9998451 1 0 0 0.1161379 0.0000180 REP15
148 intracellular (GO:0005622) 4/730 0.9998728 1 0 0 0.2615490 0.0000333 ARHGAP40;ANO7;ALOX15B;NKX3-1
149 extracellular vesicular exosome (GO:0070062) 31/2717 0.9999737 1 0 0 0.5446130 0.0000143 SLC26A2;CPNE4;SEMA3B;PCDH15;PLAT;ALDH1L2;NID2;THBS1;RAB43;COMP;FUT6;SULT1C2;MUC1;CUX2;APOB;SERPINB4;ENTPD2;CDSN;AHSG;ALOX15B;MUC5AC;ANO1;AZGP1;BPIFB2;CEACAM5;PXDN;LCN2;CPE;CDH15;FKBP5;AQP7P3
150 cytosol (GO:0005829) 12/2529 0.9999945 1 0 0 0.2264897 0.0000012 SULT1C2;NTRK2;ARHGAP40;ZBTB16;NEK6;HKDC1;TNNI3;FLNC;PKHD1L1;APOB;ALOX15B;MYLK3
151 nucleolus (GO:0005730) 3/1653 0.9999951 1 0 0 0.0866292 0.0000004 PHACTR3;PTHLH;FKBP5
152 mitochondrion (GO:0005739) 5/1269 0.9999954 1 0 0 0.1880721 0.0000009 TPO;PYCR1;SERHL2;ALDH1L2;CYP17A1

GO_Molecular_Function_2015

go_molecular %>%
  knitr::kable(
    format = "html", align = rep("c", ncol(go_molecular) + 1),
    row.names = TRUE
  ) %>%
  kableExtra::kable_styling() %>%
  kableExtra::scroll_box(height = "300px")
Term Overlap P.value Adjusted.P.value Old.P.value Old.Adjusted.P.value Odds.Ratio Combined.Score Genes
1 extracellular matrix structural constituent (GO:0005201) 6/68 0.0029878 1 0 0 4.2117085 24.4835709 COMP;FBN2;PXDN;MUC3A;MUC5AC;MUC6
2 collagen binding (GO:0005518) 5/62 0.0095910 1 0 0 3.8494110 17.8879540 COMP;C1QTNF1;ITGA10;NID2;THBS1
3 intracellular calcium activated chloride channel activity (GO:0005229) 2/12 0.0251521 1 0 0 7.9554495 29.2984249 ANO1;ANO7
4 nucleoside-diphosphatase activity (GO:0017110) 2/13 0.0293193 1 0 0 7.3434918 25.9189276 ENTPD2;ENTPD8
5 ion gated channel activity (GO:0022839) 3/40 0.0509843 1 0 0 3.5799523 10.6547898 ANO1;KCNN2;ANO7
6 peroxidase activity (GO:0004601) 3/42 0.0574810 1 0 0 3.4094783 9.7384978 TPO;PXDN;PTGS2
7 oxidoreductase activity, acting on peroxide as acceptor (GO:0016684) 3/42 0.0574810 1 0 0 3.4094783 9.7384978 TPO;PXDN;PTGS2
8 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor (GO:0016646) 2/19 0.0592174 1 0 0 5.0244944 14.2019371 PYCR1;ALDH1L2
9 phosphatidylserine binding (GO:0001786) 2/23 0.0829959 1 0 0 4.1506693 10.3308677 JPH2;THBS1
10 tetrapyrrole binding (GO:0046906) 6/146 0.0870458 1 0 0 1.9616177 4.7889376 TPO;TCN1;PXDN;PTGS2;CYP3A5;CYP17A1
11 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen (GO:0016702) 2/25 0.0958000 1 0 0 3.8186158 8.9565341 PTGS2;ALOX15B
12 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen (GO:0016701) 2/26 0.1023997 1 0 0 3.6717459 8.3674372 PTGS2;ALOX15B
13 calmodulin-dependent protein kinase activity (GO:0004683) 2/26 0.1023997 1 0 0 3.6717459 8.3674372 PNCK;MYLK3
14 proteoglycan binding (GO:0043394) 2/27 0.1091201 1 0 0 3.5357553 7.8327816 COMP;THBS1
15 oxidoreductase activity, acting on the CH-NH group of donors (GO:0016645) 2/28 0.1159532 1 0 0 3.4094783 7.3459547 PYCR1;ALDH1L2
16 organic acid:sodium symporter activity (GO:0005343) 2/28 0.1159532 1 0 0 3.4094783 7.3459547 SLC6A1;SLC13A5
17 calcium activated cation channel activity (GO:0005227) 2/29 0.1228915 1 0 0 3.2919101 6.9013369 ANO1;KCNN2
18 GPI anchor binding (GO:0034235) 1/8 0.1558373 1 0 0 5.9665871 11.0915436 CEACAM5
19 alpha-(1->3)-fucosyltransferase activity (GO:0046920) 1/8 0.1558373 1 0 0 5.9665871 11.0915436 FUT6
20 phospholipid scramblase activity (GO:0017128) 1/8 0.1558373 1 0 0 5.9665871 11.0915436 ANO7
21 AT DNA binding (GO:0003680) 1/8 0.1558373 1 0 0 5.9665871 11.0915436 PAX6
22 transcription corepressor binding (GO:0001222) 1/8 0.1558373 1 0 0 5.9665871 11.0915436 SIX3
23 phosphatidylinositol-5-phosphate binding (GO:0010314) 1/8 0.1558373 1 0 0 5.9665871 11.0915436 JPH2
24 hydroxymethyl-, formyl- and related transferase activity (GO:0016742) 1/8 0.1558373 1 0 0 5.9665871 11.0915436 ALDH1L2
25 ion channel inhibitor activity (GO:0008200) 2/34 0.1589105 1 0 0 2.8078057 5.1647173 ANKRD36C;TNNI3
26 galactosyltransferase activity (GO:0008378) 2/34 0.1589105 1 0 0 2.8078057 5.1647173 B3GNT6;ABO
27 heme binding (GO:0020037) 5/137 0.1608405 1 0 0 1.7420692 3.1833567 TPO;PXDN;PTGS2;CYP3A5;CYP17A1
28 channel inhibitor activity (GO:0016248) 2/35 0.1663335 1 0 0 2.7275827 4.8926297 ANKRD36C;TNNI3
29 heparin binding (GO:0008201) 5/140 0.1711062 1 0 0 1.7047392 3.0096678 COMP;REG4;LIPG;APOB;THBS1
30 neurotrophin binding (GO:0043121) 1/9 0.1735296 1 0 0 5.3036330 9.2888214 NTRK2
31 aldehyde-lyase activity (GO:0016832) 1/9 0.1735296 1 0 0 5.3036330 9.2888214 CYP17A1
32 protein binding involved in cell adhesion (GO:0098631) 1/9 0.1735296 1 0 0 5.3036330 9.2888214 ITGA10
33 adrenergic receptor activity (GO:0004935) 1/9 0.1735296 1 0 0 5.3036330 9.2888214 ADRA2A
34 cobalamin binding (GO:0031419) 1/9 0.1735296 1 0 0 5.3036330 9.2888214 TCN1
35 frizzled binding (GO:0005109) 2/36 0.1738152 1 0 0 2.6518165 4.6400487 WNT16;CTHRC1
36 antioxidant activity (GO:0016209) 3/70 0.1811279 1 0 0 2.0456870 3.4951626 TPO;PXDN;PTGS2
37 oxygen binding (GO:0019825) 2/37 0.1813500 1 0 0 2.5801458 4.4051511 CYP3A5;CYP17A1
38 transcription cofactor binding (GO:0001221) 1/10 0.1908519 1 0 0 4.7732697 7.9057641 SIX3
39 sodium:amino acid symporter activity (GO:0005283) 1/10 0.1908519 1 0 0 4.7732697 7.9057641 SLC6A1
40 GTP-Rho binding (GO:0017049) 1/10 0.1908519 1 0 0 4.7732697 7.9057641 CDC42EP5
41 sodium:dicarboxylate symporter activity (GO:0017153) 1/10 0.1908519 1 0 0 4.7732697 7.9057641 SLC13A5
42 semaphorin receptor binding (GO:0030215) 1/10 0.1908519 1 0 0 4.7732697 7.9057641 SEMA6B
43 RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity (GO:0000983) 1/10 0.1908519 1 0 0 4.7732697 7.9057641 NKX3-1
44 high voltage-gated calcium channel activity (GO:0008331) 1/10 0.1908519 1 0 0 4.7732697 7.9057641 CACNA1E
45 calcium channel inhibitor activity (GO:0019855) 1/11 0.2078120 1 0 0 4.3393361 6.8176239 TNNI3
46 receptor antagonist activity (GO:0048019) 1/11 0.2078120 1 0 0 4.3393361 6.8176239 PXDN
47 cholesterol transporter activity (GO:0017127) 1/11 0.2078120 1 0 0 4.3393361 6.8176239 APOB
48 secondary active sulfate transmembrane transporter activity (GO:0008271) 1/11 0.2078120 1 0 0 4.3393361 6.8176239 SLC26A2
49 phospholipid transporter activity (GO:0005548) 2/41 0.2119125 1 0 0 2.3284242 3.6127403 ATP10B;ANO7
50 G-protein coupled amine receptor activity (GO:0008227) 2/41 0.2119125 1 0 0 2.3284242 3.6127403 CHRM1;ADRA2A
51 thioesterase binding (GO:0031996) 1/12 0.2244175 1 0 0 3.9777247 5.9437046 ADRA2A
52 cation:amino acid symporter activity (GO:0005416) 1/12 0.2244175 1 0 0 3.9777247 5.9437046 SLC6A1
53 co-SMAD binding (GO:0070410) 1/12 0.2244175 1 0 0 3.9777247 5.9437046 PAX6
54 sterol transporter activity (GO:0015248) 1/12 0.2244175 1 0 0 3.9777247 5.9437046 APOB
55 receptor inhibitor activity (GO:0030547) 1/12 0.2244175 1 0 0 3.9777247 5.9437046 PXDN
56 low-density lipoprotein particle receptor binding (GO:0050750) 1/13 0.2406756 1 0 0 3.6717459 5.2296866 APOB
57 phosphatidylinositol-3,5-bisphosphate binding (GO:0080025) 1/13 0.2406756 1 0 0 3.6717459 5.2296866 JPH2
58 neurexin family protein binding (GO:0042043) 1/13 0.2406756 1 0 0 3.6717459 5.2296866 CPE
59 glycoprotein binding (GO:0001948) 3/81 0.2409331 1 0 0 1.7678777 2.5161070 COMP;AZGP1;THBS1
60 hormone activity (GO:0005179) 4/122 0.2530952 1 0 0 1.5650065 2.1503028 EDN2;ADM2;STC1;PTHLH
61 catecholamine binding (GO:1901338) 1/14 0.2565938 1 0 0 3.4094783 4.6377803 ADRA2A
62 sulfate transmembrane transporter activity (GO:0015116) 1/14 0.2565938 1 0 0 3.4094783 4.6377803 SLC26A2
63 fucosyltransferase activity (GO:0008417) 1/14 0.2565938 1 0 0 3.4094783 4.6377803 FUT6
64 phosphatidylinositol-4-phosphate binding (GO:0070273) 1/14 0.2565938 1 0 0 3.4094783 4.6377803 JPH2
65 chemokine activity (GO:0008009) 2/47 0.2585036 1 0 0 2.0311786 2.7478708 CCL24;CXCL2
66 anion:cation symporter activity (GO:0015296) 2/48 0.2663018 1 0 0 1.9888624 2.6315136 SLC6A1;SLC13A5
67 low-density lipoprotein particle binding (GO:0030169) 1/15 0.2721791 1 0 0 3.1821798 4.1409551 THBS1
68 protein transmembrane transporter activity (GO:0008320) 1/15 0.2721791 1 0 0 3.1821798 4.1409551 AZGP1
69 FMN binding (GO:0010181) 1/15 0.2721791 1 0 0 3.1821798 4.1409551 CREG2
70 phospholipid-translocating ATPase activity (GO:0004012) 1/15 0.2721791 1 0 0 3.1821798 4.1409551 ATP10B
71 lipid transporter activity (GO:0005319) 3/87 0.2748154 1 0 0 1.6459551 2.1260073 ATP10B;ANO7;APOB
72 solute:sodium symporter activity (GO:0015370) 2/50 0.2818931 1 0 0 1.9093079 2.4176177 SLC6A1;SLC13A5
73 transforming growth factor beta binding (GO:0050431) 1/16 0.2874383 1 0 0 2.9832936 3.7194122 THBS1
74 steroid hydroxylase activity (GO:0008395) 1/16 0.2874383 1 0 0 2.9832936 3.7194122 CYP17A1
75 calcium-release channel activity (GO:0015278) 1/16 0.2874383 1 0 0 2.9832936 3.7194122 JPH2
76 triglyceride lipase activity (GO:0004806) 1/16 0.2874383 1 0 0 2.9832936 3.7194122 LIPG
77 cytokine activity (GO:0005125) 6/213 0.2891544 1 0 0 1.3445830 1.6683513 CCL24;LEFTY1;CSF3;BMP8A;IL19;CXCL2
78 symporter activity (GO:0015293) 4/130 0.2902174 1 0 0 1.4686984 1.8169632 SLC25A18;SLC6A1;SLC13A5;SLC16A14
79 macromolecule transmembrane transporter activity (GO:0022884) 1/17 0.3023784 1 0 0 2.8078057 3.3583490 AZGP1
80 FK506 binding (GO:0005528) 1/17 0.3023784 1 0 0 2.8078057 3.3583490 FKBP5
81 macrolide binding (GO:0005527) 1/17 0.3023784 1 0 0 2.8078057 3.3583490 FKBP5
82 calcium-activated potassium channel activity (GO:0015269) 1/17 0.3023784 1 0 0 2.8078057 3.3583490 KCNN2
83 heparan sulfate proteoglycan binding (GO:0043395) 1/17 0.3023784 1 0 0 2.8078057 3.3583490 COMP
84 peptide hormone receptor binding (GO:0051428) 1/17 0.3023784 1 0 0 2.8078057 3.3583490 PTHLH
85 modified amino acid binding (GO:0072341) 2/53 0.3052188 1 0 0 1.8012338 2.1375715 JPH2;THBS1
86 transmembrane receptor protein phosphatase activity (GO:0019198) 1/18 0.3170060 1 0 0 2.6518165 3.0464985 PTPRH
87 transmembrane receptor protein tyrosine phosphatase activity (GO:0005001) 1/18 0.3170060 1 0 0 2.6518165 3.0464985 PTPRH
88 HMG box domain binding (GO:0071837) 1/18 0.3170060 1 0 0 2.6518165 3.0464985 PAX6
89 pattern binding (GO:0001871) 1/18 0.3170060 1 0 0 2.6518165 3.0464985 REG4
90 cysteine-type endopeptidase activator activity involved in apoptotic process (GO:0008656) 1/18 0.3170060 1 0 0 2.6518165 3.0464985 NKX3-1
91 acetylcholine receptor activity (GO:0015464) 1/18 0.3170060 1 0 0 2.6518165 3.0464985 CHRM1
92 lipoprotein particle receptor binding (GO:0070325) 1/18 0.3170060 1 0 0 2.6518165 3.0464985 APOB
93 polysaccharide binding (GO:0030247) 1/18 0.3170060 1 0 0 2.6518165 3.0464985 REG4
94 calcium-dependent protein binding (GO:0048306) 2/56 0.3284002 1 0 0 1.7047392 1.8982650 TNNI3;SYT8
95 histone acetyltransferase binding (GO:0035035) 1/19 0.3313276 1 0 0 2.5122472 2.7751481 PAX6
96 adrenergic receptor binding (GO:0031690) 1/19 0.3313276 1 0 0 2.5122472 2.7751481 ADRA2A
97 neurotransmitter:sodium symporter activity (GO:0005328) 1/19 0.3313276 1 0 0 2.5122472 2.7751481 SLC6A1
98 chemokine receptor binding (GO:0042379) 2/57 0.3360828 1 0 0 1.6748315 1.8262323 CCL24;CXCL2
99 carbohydrate kinase activity (GO:0019200) 1/20 0.3453496 1 0 0 2.3866348 2.5374656 HKDC1
100 fibroblast growth factor binding (GO:0017134) 1/20 0.3453496 1 0 0 2.3866348 2.5374656 THBS1
101 UDP-galactosyltransferase activity (GO:0035250) 1/20 0.3453496 1 0 0 2.3866348 2.5374656 ABO
102 alpha-actinin binding (GO:0051393) 1/20 0.3453496 1 0 0 2.3866348 2.5374656 KCNN2
103 ankyrin binding (GO:0030506) 1/21 0.3590782 1 0 0 2.2729856 2.3280260 FLNC
104 aromatase activity (GO:0070330) 1/21 0.3590782 1 0 0 2.2729856 2.3280260 CYP3A5
105 peptidase activator activity involved in apoptotic process (GO:0016505) 1/21 0.3590782 1 0 0 2.2729856 2.3280260 NKX3-1
106 glycosaminoglycan binding (GO:0005539) 5/190 0.3672648 1 0 0 1.2561236 1.2582240 COMP;REG4;LIPG;APOB;THBS1
107 secondary active transmembrane transporter activity (GO:0015291) 5/191 0.3714210 1 0 0 1.2495470 1.2375754 SLC26A2;SLC25A18;SLC6A1;SLC13A5;SLC16A14
108 phosphatidylinositol-3-phosphate binding (GO:0032266) 1/22 0.3725196 1 0 0 2.1696680 2.1424725 JPH2
109 transforming growth factor beta receptor binding (GO:0005160) 1/22 0.3725196 1 0 0 2.1696680 2.1424725 LEFTY1
110 R-SMAD binding (GO:0070412) 1/22 0.3725196 1 0 0 2.1696680 2.1424725 PAX6
111 Hsp70 protein binding (GO:0030544) 1/22 0.3725196 1 0 0 2.1696680 2.1424725 GPR37
112 heat shock protein binding (GO:0031072) 2/63 0.3815500 1 0 0 1.5153237 1.4600346 GPR37;FKBP5
113 glycolipid binding (GO:0051861) 1/23 0.3856798 1 0 0 2.0753346 1.9772706 CEACAM5
114 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription (GO:0001205) 1/23 0.3856798 1 0 0 2.0753346 1.9772706 SIX3
115 purinergic receptor activity (GO:0035586) 1/23 0.3856798 1 0 0 2.0753346 1.9772706 ADORA3
116 metallocarboxypeptidase activity (GO:0004181) 1/24 0.3985646 1 0 0 1.9888624 1.8295261 CPE
117 lipoprotein particle binding (GO:0071813) 1/24 0.3985646 1 0 0 1.9888624 1.8295261 THBS1
118 protein-lipid complex binding (GO:0071814) 1/24 0.3985646 1 0 0 1.9888624 1.8295261 THBS1
119 neurotransmitter transporter activity (GO:0005326) 1/24 0.3985646 1 0 0 1.9888624 1.8295261 SLC6A1
120 dicarboxylic acid transmembrane transporter activity (GO:0005310) 1/24 0.3985646 1 0 0 1.9888624 1.8295261 SLC13A5
121 anion transmembrane transporter activity (GO:0008509) 6/245 0.4076792 1 0 0 1.1689640 1.0488818 ANO1;SLC26A2;SLCO1B3;ANO7;SLC6A1;SLC13A5
122 Rho GTPase binding (GO:0017048) 2/67 0.4111207 1 0 0 1.4248566 1.2665099 DAAM2;CDC42EP5
123 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen (GO:0016712) 1/25 0.4111798 1 0 0 1.9093079 1.6968492 CYP3A5
124 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor (GO:0033764) 1/25 0.4111798 1 0 0 1.9093079 1.6968492 HSD11B2
125 actinin binding (GO:0042805) 1/25 0.4111798 1 0 0 1.9093079 1.6968492 KCNN2
126 sulfur compound transmembrane transporter activity (GO:1901682) 1/26 0.4235310 1 0 0 1.8358730 1.5772510 SLC26A2
127 fibronectin binding (GO:0001968) 1/26 0.4235310 1 0 0 1.8358730 1.5772510 THBS1
128 sulfur compound binding (GO:1901681) 5/206 0.4335324 1 0 0 1.1585606 0.9683119 COMP;REG4;LIPG;APOB;THBS1
129 glutamate receptor activity (GO:0008066) 1/27 0.4356237 1 0 0 1.7678777 1.4690648 GRM8
130 Wnt-protein binding (GO:0017147) 1/27 0.4356237 1 0 0 1.7678777 1.4690648 CTHRC1
131 peptidase regulator activity (GO:0061134) 5/209 0.4458296 1 0 0 1.1419305 0.9224727 SERPINB4;AHSG;HMSD;SSPO;NKX3-1
132 growth factor activity (GO:0008083) 4/163 0.4461966 1 0 0 1.1713545 0.9452780 CSF3;LEFTY1;BMP8A;TFF1
133 chloride channel activity (GO:0005254) 2/72 0.4470730 1 0 0 1.3259082 1.0674003 ANO1;ANO7
134 phosphatidylinositol phospholipase C activity (GO:0004435) 1/28 0.4474633 1 0 0 1.7047392 1.3708842 CHRM1
135 steroid dehydrogenase activity (GO:0016229) 1/28 0.4474633 1 0 0 1.7047392 1.3708842 HSD11B2
136 estrogen receptor binding (GO:0030331) 1/28 0.4474633 1 0 0 1.7047392 1.3708842 NKX3-1
137 inorganic anion transmembrane transporter activity (GO:0015103) 3/119 0.4561068 1 0 0 1.2033453 0.9446602 ANO1;SLC26A2;ANO7
138 kinesin binding (GO:0019894) 1/29 0.4590552 1 0 0 1.6459551 1.2815157 NEK6
139 phospholipase C activity (GO:0004629) 1/30 0.4704044 1 0 0 1.5910899 1.1999403 CHRM1
140 monocarboxylic acid transmembrane transporter activity (GO:0008028) 1/30 0.4704044 1 0 0 1.5910899 1.1999403 SLC6A1
141 phosphatidylinositol-3,4,5-trisphosphate binding (GO:0005547) 1/30 0.4704044 1 0 0 1.5910899 1.1999403 JPH2
142 laminin binding (GO:0043236) 1/30 0.4704044 1 0 0 1.5910899 1.1999403 THBS1
143 growth factor binding (GO:0019838) 3/123 0.4777203 1 0 0 1.1642121 0.8600382 NTRK2;PXDN;THBS1
144 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor (GO:0016620) 1/31 0.4815161 1 0 0 1.5397644 1.1252839 ALDH1L2
145 ephrin receptor binding (GO:0046875) 1/31 0.4815161 1 0 0 1.5397644 1.1252839 NTRK2
146 calcium channel regulator activity (GO:0005246) 1/31 0.4815161 1 0 0 1.5397644 1.1252839 TNNI3
147 iron ion binding (GO:0005506) 4/172 0.4874009 1 0 0 1.1100627 0.7977670 LCN2;ALOX15B;CYP3A5;CYP17A1
148 cytokine binding (GO:0019955) 2/78 0.4885395 1 0 0 1.2239153 0.8767333 PXDN;THBS1
149 peptidase inhibitor activity (GO:0030414) 4/173 0.4919047 1 0 0 1.1036462 0.7830041 SERPINB4;AHSG;HMSD;SSPO
150 anion channel activity (GO:0005253) 2/80 0.5019244 1 0 0 1.1933174 0.8225606 ANO1;ANO7
151 organic anion transmembrane transporter activity (GO:0008514) 3/130 0.5145426 1 0 0 1.1015238 0.7319371 SLCO1B3;SLC6A1;SLC13A5
152 solute:cation symporter activity (GO:0015294) 2/82 0.5150817 1 0 0 1.1642121 0.7723730 SLC6A1;SLC13A5
153 cytokine receptor binding (GO:0005126) 5/228 0.5217758 1 0 0 1.0467697 0.6809418 CCL24;LEFTY1;CSF3;PXDN;CXCL2
154 peptide antigen binding (GO:0042605) 1/35 0.5236849 1 0 0 1.3637913 0.8821891 AZGP1
155 acetylgalactosaminyltransferase activity (GO:0008376) 1/35 0.5236849 1 0 0 1.3637913 0.8821891 ABO
156 G-protein coupled receptor binding (GO:0001664) 5/229 0.5256558 1 0 0 1.0421986 0.6702470 CCL24;WNT16;CXCL2;ADRA2A;CTHRC1
157 ATP-dependent DNA helicase activity (GO:0004003) 1/36 0.5336812 1 0 0 1.3259082 0.8326130 RTEL1-TNFRSF6B
158 protein phosphatase inhibitor activity (GO:0004864) 1/36 0.5336812 1 0 0 1.3259082 0.8326130 PHACTR3
159 calcium-dependent phospholipid binding (GO:0005544) 1/36 0.5336812 1 0 0 1.3259082 0.8326130 DOC2B
160 chloride transmembrane transporter activity (GO:0015108) 2/86 0.5406975 1 0 0 1.1100627 0.6825724 ANO1;ANO7
161 peptidase activator activity (GO:0016504) 1/37 0.5434681 1 0 0 1.2900729 0.7866661 NKX3-1
162 dioxygenase activity (GO:0051213) 2/87 0.5469535 1 0 0 1.0973034 0.6621035 PTGS2;ALOX15B
163 RNA polymerase II regulatory region sequence-specific DNA binding (GO:0000977) 6/284 0.5489403 1 0 0 1.0084373 0.6048260 MUC1;CUX2;SIX3;PAX6;BHLHA15;FEZF1
164 phosphatase inhibitor activity (GO:0019212) 1/38 0.5530502 1 0 0 1.2561236 0.7440102 PHACTR3
165 metalloexopeptidase activity (GO:0008235) 1/39 0.5624316 1 0 0 1.2239153 0.7043459 CPE
166 cysteine-type endopeptidase regulator activity involved in apoptotic process (GO:0043028) 1/39 0.5624316 1 0 0 1.2239153 0.7043459 NKX3-1
167 RNA polymerase II regulatory region DNA binding (GO:0001012) 6/288 0.5626366 1 0 0 0.9944312 0.5719185 MUC1;CUX2;SIX3;PAX6;BHLHA15;FEZF1
168 phospholipase activity (GO:0004620) 2/90 0.5653620 1 0 0 1.0607266 0.6049208 CHRM1;LIPG
169 transcription regulatory region sequence-specific DNA binding (GO:0000976) 7/340 0.5715885 1 0 0 0.9827320 0.5496773 MUC1;CUX2;SIX3;PAX6;BHLHA15;FEZF1;NKX3-1
170 protein self-association (GO:0043621) 1/40 0.5716165 1 0 0 1.1933174 0.6674069 NKX3-1
171 carboxypeptidase activity (GO:0004180) 1/40 0.5716165 1 0 0 1.1933174 0.6674069 CPE
172 peptidyl-prolyl cis-trans isomerase activity (GO:0003755) 1/41 0.5806091 1 0 0 1.1642121 0.6329560 FKBP5
173 phosphatidylinositol-4,5-bisphosphate binding (GO:0005546) 1/41 0.5806091 1 0 0 1.1642121 0.6329560 JPH2
174 drug binding (GO:0008144) 2/93 0.5832269 1 0 0 1.0265096 0.5534724 CHRM1;FKBP5
175 oxidoreductase activity, acting on the aldehyde or oxo group of donors (GO:0016903) 1/42 0.5894134 1 0 0 1.1364928 0.6007814 ALDH1L2
176 receptor regulator activity (GO:0030545) 1/42 0.5894134 1 0 0 1.1364928 0.6007814 PXDN
177 RNA polymerase II core promoter sequence-specific DNA binding (GO:0000979) 1/43 0.5980332 1 0 0 1.1100627 0.5706932 PAX6
178 cis-trans isomerase activity (GO:0016859) 1/43 0.5980332 1 0 0 1.1100627 0.5706932 FKBP5
179 acetylglucosaminyltransferase activity (GO:0008375) 1/44 0.6064726 1 0 0 1.0848340 0.5425209 B3GNT6
180 syntaxin binding (GO:0019905) 1/44 0.6064726 1 0 0 1.0848340 0.5425209 STXBP5L
181 voltage-gated calcium channel activity (GO:0005245) 1/44 0.6064726 1 0 0 1.0848340 0.5425209 CACNA1E
182 actin filament binding (GO:0051015) 2/98 0.6117869 1 0 0 0.9741367 0.4786628 SHROOM1;FLNC
183 serine-type endopeptidase inhibitor activity (GO:0004867) 2/98 0.6117869 1 0 0 0.9741367 0.4786628 SERPINB4;HMSD
184 monooxygenase activity (GO:0004497) 2/99 0.6173166 1 0 0 0.9642969 0.4651511 CYP3A5;CYP17A1
185 active transmembrane transporter activity (GO:0022804) 6/307 0.6248122 1 0 0 0.9328866 0.4387404 SLC26A2;SLC25A18;ATP10B;SLC6A1;SLC13A5;SLC16A14
186 carboxylic acid transmembrane transporter activity (GO:0046943) 2/101 0.6281942 1 0 0 0.9452019 0.4394299 SLC6A1;SLC13A5
187 channel regulator activity (GO:0016247) 2/102 0.6335424 1 0 0 0.9359352 0.4271873 ANKRD36C;TNNI3
188 organic acid transmembrane transporter activity (GO:0005342) 2/104 0.6440582 1 0 0 0.9179365 0.4038609 SLC6A1;SLC13A5
189 protein kinase activator activity (GO:0030295) 1/49 0.6460903 1 0 0 0.9741367 0.4255184 NKX3-1
190 cysteine-type endopeptidase inhibitor activity (GO:0004869) 1/49 0.6460903 1 0 0 0.9741367 0.4255184 AHSG
191 lipase activity (GO:0016298) 2/105 0.6492262 1 0 0 0.9091942 0.3927483 CHRM1;LIPG
192 ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity (GO:0004879) 1/50 0.6535229 1 0 0 0.9546539 0.4060885 NKX3-1
193 NAD binding (GO:0051287) 1/50 0.6535229 1 0 0 0.9546539 0.4060885 HSD11B2
194 direct ligand regulated sequence-specific DNA binding transcription factor activity (GO:0098531) 1/50 0.6535229 1 0 0 0.9546539 0.4060885 NKX3-1
195 amino acid binding (GO:0016597) 2/107 0.6593834 1 0 0 0.8921999 0.3715567 JPH2;THBS1
196 DNA helicase activity (GO:0003678) 1/51 0.6607998 1 0 0 0.9359352 0.3877621 RTEL1-TNFRSF6B
197 extracellular matrix binding (GO:0050840) 1/51 0.6607998 1 0 0 0.9359352 0.3877621 THBS1
198 carbon-carbon lyase activity (GO:0016830) 1/51 0.6607998 1 0 0 0.9359352 0.3877621 CYP17A1
199 calcium channel activity (GO:0005262) 2/108 0.6643731 1 0 0 0.8839388 0.3614526 JPH2;CACNA1E
200 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen (GO:0016705) 3/163 0.6670891 1 0 0 0.8785159 0.3556511 PTGS2;CYP3A5;CYP17A1
201 sulfotransferase activity (GO:0008146) 1/52 0.6679242 1 0 0 0.9179365 0.3704614 SULT1C2
202 double-stranded DNA binding (GO:0003690) 2/109 0.6693038 1 0 0 0.8758293 0.3516605 ZBTB16;PAX6
203 copper ion binding (GO:0005507) 1/53 0.6748993 1 0 0 0.9006169 0.3541152 F5
204 core promoter binding (GO:0001047) 2/111 0.6789896 1 0 0 0.8600486 0.3329674 PAX6;NKX3-1
205 endopeptidase inhibitor activity (GO:0004866) 3/166 0.6790707 1 0 0 0.8626391 0.3338672 SERPINB4;AHSG;HMSD
206 RNA polymerase II core promoter proximal region sequence-specific DNA binding (GO:0000978) 3/167 0.6829931 1 0 0 0.8574736 0.3269295 MUC1;PAX6;FEZF1
207 kinase activator activity (GO:0019209) 1/55 0.6884140 1 0 0 0.8678672 0.3240311 NKX3-1
208 RNA polymerase II distal enhancer sequence-specific DNA binding (GO:0000980) 1/56 0.6949597 1 0 0 0.8523696 0.3101785 SIX3
209 phosphatidylinositol bisphosphate binding (GO:1902936) 1/56 0.6949597 1 0 0 0.8523696 0.3101785 JPH2
210 p53 binding (GO:0002039) 1/56 0.6949597 1 0 0 0.8523696 0.3101785 MUC1
211 endopeptidase regulator activity (GO:0061135) 3/171 0.6983256 1 0 0 0.8374157 0.3006907 SERPINB4;AHSG;HMSD
212 steroid hormone receptor activity (GO:0003707) 1/57 0.7013682 1 0 0 0.8374157 0.2970500 NKX3-1
213 kinase inhibitor activity (GO:0019210) 1/57 0.7013682 1 0 0 0.8374157 0.2970500 AHSG
214 SNARE binding (GO:0000149) 1/59 0.7137851 1 0 0 0.8090288 0.2727830 STXBP5L
215 core promoter proximal region sequence-specific DNA binding (GO:0000987) 3/176 0.7166933 1 0 0 0.8136255 0.2710246 MUC1;PAX6;FEZF1
216 core promoter proximal region DNA binding (GO:0001159) 3/178 0.7237942 1 0 0 0.8044837 0.2600478 MUC1;PAX6;FEZF1
217 transferase activity, transferring sulfur-containing groups (GO:0016782) 1/64 0.7426200 1 0 0 0.7458234 0.2219352 SULT1C2
218 phospholipid binding (GO:0005543) 5/296 0.7459211 1 0 0 0.8062956 0.2363538 JPH2;CEACAM5;DOC2B;APOB;THBS1
219 transmembrane receptor protein tyrosine kinase activity (GO:0004714) 1/65 0.7480294 1 0 0 0.7343492 0.2131911 NTRK2
220 protein phosphatase regulator activity (GO:0019888) 1/65 0.7480294 1 0 0 0.7343492 0.2131911 PHACTR3
221 cation-transporting ATPase activity (GO:0019829) 1/65 0.7480294 1 0 0 0.7343492 0.2131911 ATP10B
222 calcium ion transmembrane transporter activity (GO:0015085) 2/127 0.7483486 1 0 0 0.7516960 0.2179064 JPH2;CACNA1E
223 sodium ion transmembrane transporter activity (GO:0015081) 2/128 0.7522246 1 0 0 0.7458234 0.2123511 SLC6A1;SLC13A5
224 amino acid transmembrane transporter activity (GO:0015171) 1/66 0.7533254 1 0 0 0.7232227 0.2048586 SLC6A1
225 ATPase activity, coupled to transmembrane movement of ions (GO:0042625) 1/67 0.7585103 1 0 0 0.7124283 0.1969144 ATP10B
226 steroid hormone receptor binding (GO:0035258) 1/67 0.7585103 1 0 0 0.7124283 0.1969144 NKX3-1
227 magnesium ion binding (GO:0000287) 3/190 0.7635108 1 0 0 0.7536742 0.2033624 NEK6;ATP10B;IRAK3
228 SMAD binding (GO:0046332) 1/68 0.7635865 1 0 0 0.7019514 0.1893366 PAX6
229 UDP-glycosyltransferase activity (GO:0008194) 2/132 0.7672185 1 0 0 0.7232227 0.1916422 B3GNT6;ABO
230 enhancer sequence-specific DNA binding (GO:0001158) 1/70 0.7734217 1 0 0 0.6818957 0.1752000 SIX3
231 transferase activity, transferring hexosyl groups (GO:0016758) 3/194 0.7756778 1 0 0 0.7381345 0.1874994 FUT6;B3GNT6;ABO
232 core promoter sequence-specific DNA binding (GO:0001046) 1/71 0.7781852 1 0 0 0.6722915 0.1686045 PAX6
233 neurotransmitter receptor activity (GO:0030594) 1/74 0.7918844 1 0 0 0.6450364 0.1505127 CHRM1
234 phosphatase regulator activity (GO:0019208) 1/75 0.7962606 1 0 0 0.6364360 0.1449984 PHACTR3
235 histone deacetylase binding (GO:0042826) 1/75 0.7962606 1 0 0 0.6364360 0.1449984 NKX3-1
236 kinase regulator activity (GO:0019207) 2/141 0.7980965 1 0 0 0.6770595 0.1526943 AHSG;NKX3-1
237 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription (GO:0001228) 3/202 0.7984723 1 0 0 0.7089014 0.1595418 SIX3;PAX6;BHLHA15
238 protease binding (GO:0002020) 1/77 0.8047394 1 0 0 0.6199052 0.1346662 COMP
239 gated channel activity (GO:0022836) 5/323 0.8098460 1 0 0 0.7388962 0.1558415 ANO1;JPH2;KCNN2;ANO7;CACNA1E
240 DNA-dependent ATPase activity (GO:0008094) 1/80 0.8168022 1 0 0 0.5966587 0.1207388 RTEL1-TNFRSF6B
241 vitamin binding (GO:0019842) 1/80 0.8168022 1 0 0 0.5966587 0.1207388 TCN1
242 protein transporter activity (GO:0008565) 1/81 0.8206556 1 0 0 0.5892926 0.1164747 AZGP1
243 actin binding (GO:0003779) 6/386 0.8221131 1 0 0 0.7419590 0.1453330 SNTG2;DAAM2;PHACTR3;TNNI3;FLNC;SHROOM1
244 transmembrane receptor protein kinase activity (GO:0019199) 1/82 0.8244281 1 0 0 0.5821061 0.1123845 NTRK2
245 steroid binding (GO:0005496) 1/82 0.8244281 1 0 0 0.5821061 0.1123845 HSD11B2
246 helicase activity (GO:0004386) 2/150 0.8252959 1 0 0 0.6364360 0.1222042 RTEL1-TNFRSF6B;DQX1
247 enhancer binding (GO:0035326) 1/83 0.8281214 1 0 0 0.5750927 0.1084599 SIX3
248 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity (GO:0003705) 1/84 0.8317373 1 0 0 0.5682464 0.1046930 SIX3
249 cytokine receptor activity (GO:0004896) 1/85 0.8352772 1 0 0 0.5615611 0.1010763 IL1R2
250 enzyme inhibitor activity (GO:0004857) 5/336 0.8357199 1 0 0 0.7103080 0.1274731 SERPINB4;AHSG;HMSD;PHACTR3;SSPO
251 divalent inorganic cation transmembrane transporter activity (GO:0072509) 2/154 0.8362938 1 0 0 0.6199052 0.1108237 JPH2;CACNA1E
252 ribonuclease activity (GO:0004540) 1/86 0.8387428 1 0 0 0.5550314 0.0976029 AZGP1
253 purine NTP-dependent helicase activity (GO:0070035) 1/89 0.8487093 1 0 0 0.5363224 0.0879775 RTEL1-TNFRSF6B
254 ATP-dependent helicase activity (GO:0008026) 1/89 0.8487093 1 0 0 0.5363224 0.0879775 RTEL1-TNFRSF6B
255 cation channel activity (GO:0005261) 4/285 0.8509126 1 0 0 0.6699326 0.1081579 ANO1;JPH2;KCNN2;CACNA1E
256 hormone receptor binding (GO:0051427) 2/160 0.8516207 1 0 0 0.5966587 0.0958317 PTHLH;NKX3-1
257 phosphoric diester hydrolase activity (GO:0008081) 1/90 0.8518930 1 0 0 0.5303633 0.0850142 CHRM1
258 phosphatidylinositol phosphate binding (GO:1901981) 1/91 0.8550098 1 0 0 0.5245351 0.0821644 JPH2
259 protein C-terminus binding (GO:0008022) 2/162 0.8564324 1 0 0 0.5892926 0.0913285 ZBTB16;FIGN
260 calcium ion binding (GO:0005509) 11/698 0.8691675 1 0 0 0.7522345 0.1054778 COMP;FBN2;CGREF1;TPO;REG4;PCDH15;CDH15;ALOX15B;CACNA1E;NID2;THBS1
261 PDZ domain binding (GO:0030165) 1/96 0.8696394 1 0 0 0.4972156 0.0694494 SNTG2
262 cell adhesion molecule binding (GO:0050839) 2/168 0.8700252 1 0 0 0.5682464 0.0791187 CPE;THBS1
263 calmodulin binding (GO:0005516) 2/170 0.8742870 1 0 0 0.5615611 0.0754438 PNCK;KCNN2
264 peptide binding (GO:0042277) 2/172 0.8784200 1 0 0 0.5550314 0.0719490 AZGP1;GPR37
265 protein homodimerization activity (GO:0042803) 10/653 0.8812457 1 0 0 0.7309755 0.0924090 NTRK2;ANO1;CDSN;ZBTB16;CEACAM5;KCNN2;IRAK3;BHLHA15;PTGS2;ADRA2A
266 integrin binding (GO:0005178) 1/102 0.8852638 1 0 0 0.4679676 0.0570310 THBS1
267 protein tyrosine phosphatase activity (GO:0004725) 1/103 0.8876798 1 0 0 0.4634242 0.0552143 PTPRH
268 amide binding (GO:0033218) 2/177 0.8882102 1 0 0 0.5393525 0.0639385 AZGP1;GPR37
269 ATPase activity, coupled to transmembrane movement of substances (GO:0042626) 1/104 0.8900451 1 0 0 0.4589682 0.0534621 ATP10B
270 phosphatidylinositol binding (GO:0035091) 2/178 0.8900786 1 0 0 0.5363224 0.0624523 JPH2;CEACAM5
271 ATPase activity, coupled to movement of substances (GO:0043492) 1/105 0.8923606 1 0 0 0.4545971 0.0517718 ATP10B
272 metalloendopeptidase activity (GO:0004222) 1/106 0.8946275 1 0 0 0.4503085 0.0501409 ADAMDEC1
273 small conjugating protein ligase binding (GO:0044389) 2/182 0.8972662 1 0 0 0.5245351 0.0568610 GPR37;PAX6
274 ubiquitin protein ligase binding (GO:0031625) 2/182 0.8972662 1 0 0 0.5245351 0.0568610 GPR37;PAX6
275 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances (GO:0016820) 1/108 0.8990194 1 0 0 0.4419694 0.0470479 ATP10B
276 primary active transmembrane transporter activity (GO:0015399) 1/111 0.9052673 1 0 0 0.4300243 0.0427982 ATP10B
277 P-P-bond-hydrolysis-driven transmembrane transporter activity (GO:0015405) 1/111 0.9052673 1 0 0 0.4300243 0.0427982 ATP10B
278 exopeptidase activity (GO:0008238) 1/111 0.9052673 1 0 0 0.4300243 0.0427982 CPE
279 carboxylic ester hydrolase activity (GO:0052689) 1/111 0.9052673 1 0 0 0.4300243 0.0427982 LIPG
280 metallopeptidase activity (GO:0008237) 2/188 0.9072319 1 0 0 0.5077946 0.0494375 ADAMDEC1;CPE
281 serine-type peptidase activity (GO:0008236) 2/188 0.9072319 1 0 0 0.5077946 0.0494375 PRSS16;PLAT
282 coenzyme binding (GO:0050662) 2/188 0.9072319 1 0 0 0.5077946 0.0494375 HSD11B2;CREG2
283 serine hydrolase activity (GO:0017171) 2/191 0.9118692 1 0 0 0.4998188 0.0461126 PRSS16;PLAT
284 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor (GO:0016616) 1/115 0.9130018 1 0 0 0.4150669 0.0377783 HSD11B2
285 Ras GTPase binding (GO:0017016) 2/193 0.9148392 1 0 0 0.4946393 0.0440263 DAAM2;CDC42EP5
286 potassium channel activity (GO:0005267) 1/118 0.9183864 1 0 0 0.4045144 0.0344392 KCNN2
287 ion channel activity (GO:0005216) 5/396 0.9204088 1 0 0 0.6026856 0.0499851 ANO1;JPH2;KCNN2;ANO7;CACNA1E
288 sequence-specific DNA binding RNA polymerase II transcription factor activity (GO:0000981) 5/397 0.9214137 1 0 0 0.6011675 0.0492032 SIX3;PAX6;BHLHA15;SPDEF;NKX3-1
289 G-protein coupled peptide receptor activity (GO:0008528) 1/121 0.9234384 1 0 0 0.3944851 0.0314212 GPR37
290 growth factor receptor binding (GO:0070851) 1/121 0.9234384 1 0 0 0.3944851 0.0314212 CSF3
291 protein kinase regulator activity (GO:0019887) 1/121 0.9234384 1 0 0 0.3944851 0.0314212 NKX3-1
292 metal ion transmembrane transporter activity (GO:0046873) 5/400 0.9243615 1 0 0 0.5966587 0.0469284 JPH2;KCNN2;SLC6A1;SLC13A5;CACNA1E
293 carboxylic acid binding (GO:0031406) 2/200 0.9245113 1 0 0 0.4773270 0.0374654 JPH2;THBS1
294 organic acid binding (GO:0043177) 2/201 0.9258056 1 0 0 0.4749522 0.0366145 JPH2;THBS1
295 peptide receptor activity (GO:0001653) 1/123 0.9266318 1 0 0 0.3880707 0.0295706 GPR37
296 substrate-specific channel activity (GO:0022838) 5/406 0.9299649 1 0 0 0.5878411 0.0426822 ANO1;JPH2;KCNN2;ANO7;CACNA1E
297 transferase activity, transferring glycosyl groups (GO:0016757) 3/280 0.9350530 1 0 0 0.5114218 0.0343430 FUT6;B3GNT6;ABO
298 small GTPase binding (GO:0031267) 2/209 0.9354316 1 0 0 0.4567722 0.0304883 DAAM2;CDC42EP5
299 oxidoreductase activity, acting on CH-OH group of donors (GO:0016614) 1/131 0.9381306 1 0 0 0.3643717 0.0232710 HSD11B2
300 potassium ion transmembrane transporter activity (GO:0015079) 1/138 0.9467066 1 0 0 0.3458891 0.0189430 KCNN2
301 channel activity (GO:0015267) 5/427 0.9467779 1 0 0 0.5589309 0.0305683 ANO1;JPH2;KCNN2;ANO7;CACNA1E
302 passive transmembrane transporter activity (GO:0022803) 5/427 0.9467779 1 0 0 0.5589309 0.0305683 ANO1;JPH2;KCNN2;ANO7;CACNA1E
303 GTPase binding (GO:0051020) 2/221 0.9476823 1 0 0 0.4319701 0.0232123 DAAM2;CDC42EP5
304 nuclear hormone receptor binding (GO:0035257) 1/139 0.9478308 1 0 0 0.3434007 0.0183992 NKX3-1
305 protein tyrosine kinase activity (GO:0004713) 1/142 0.9510635 1 0 0 0.3361458 0.0168659 NTRK2
306 ligand-gated ion channel activity (GO:0015276) 1/145 0.9540962 1 0 0 0.3291910 0.0154689 JPH2
307 ligand-gated channel activity (GO:0022834) 1/145 0.9540962 1 0 0 0.3291910 0.0154689 JPH2
308 voltage-gated cation channel activity (GO:0022843) 1/149 0.9578502 1 0 0 0.3203537 0.0137957 CACNA1E
309 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription (GO:0001077) 1/151 0.9596107 1 0 0 0.3161106 0.0130325 PAX6
310 protein serine/threonine kinase activity (GO:0004674) 5/449 0.9604014 1 0 0 0.5315445 0.0214765 PNCK;PDPK2;NEK6;IRAK3;MYLK3
311 structure-specific DNA binding (GO:0043566) 2/241 0.9633299 1 0 0 0.3961220 0.0147989 ZBTB16;PAX6
312 isomerase activity (GO:0016853) 1/159 0.9659489 1 0 0 0.3002056 0.0104004 FKBP5
313 serine-type endopeptidase activity (GO:0004252) 1/167 0.9712944 1 0 0 0.2858245 0.0083248 PLAT
314 microtubule binding (GO:0008017) 1/171 0.9736444 1 0 0 0.2791386 0.0074556 JAKMIP3
315 phosphoprotein phosphatase activity (GO:0004721) 1/172 0.9742013 1 0 0 0.2775157 0.0072535 PTPRH
316 monovalent inorganic cation transmembrane transporter activity (GO:0015077) 3/343 0.9761482 1 0 0 0.4174871 0.0100785 KCNN2;SLC6A1;SLC13A5
317 GTPase activator activity (GO:0005096) 2/265 0.9762254 1 0 0 0.3602468 0.0086682 ARHGAP40;ELMOD1
318 cofactor binding (GO:0048037) 2/266 0.9766543 1 0 0 0.3588925 0.0084780 HSD11B2;CREG2
319 kinase binding (GO:0019900) 5/487 0.9766571 1 0 0 0.4900688 0.0115752 NEK6;PAX6;TNNI3;ADRA2A;JAKMIP3
320 lyase activity (GO:0016829) 1/177 0.9768143 1 0 0 0.2696763 0.0063262 CYP17A1
321 ATPase activity, coupled (GO:0042623) 2/272 0.9790748 1 0 0 0.3509757 0.0074222 RTEL1-TNFRSF6B;ATP10B
322 inorganic cation transmembrane transporter activity (GO:0022890) 5/497 0.9797583 1 0 0 0.4802082 0.0098200 JPH2;KCNN2;SLC6A1;SLC13A5;CACNA1E
323 voltage-gated channel activity (GO:0022832) 1/189 0.9820583 1 0 0 0.2525540 0.0045724 CACNA1E
324 voltage-gated ion channel activity (GO:0005244) 1/189 0.9820583 1 0 0 0.2525540 0.0045724 CACNA1E
325 protein kinase binding (GO:0019901) 4/437 0.9827203 1 0 0 0.4369126 0.0076157 NEK6;PAX6;TNNI3;ADRA2A
326 nuclease activity (GO:0004518) 1/195 0.9842180 1 0 0 0.2447831 0.0038940 AZGP1
327 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity (GO:0000982) 1/204 0.9869809 1 0 0 0.2339838 0.0030663 PAX6
328 transcription corepressor activity (GO:0003714) 1/208 0.9880485 1 0 0 0.2294841 0.0027592 TFCP2L1
329 methyltransferase activity (GO:0008168) 1/210 0.9885491 1 0 0 0.2272986 0.0026178 ALDH1L2
330 transcription factor binding (GO:0008134) 4/464 0.9886529 1 0 0 0.4114888 0.0046959 SIX3;PAX6;FOXA3;NKX3-1
331 antigen binding (GO:0003823) 1/212 0.9890288 1 0 0 0.2251542 0.0024839 AZGP1
332 GTPase regulator activity (GO:0030695) 2/310 0.9896280 1 0 0 0.3079529 0.0032108 ARHGAP40;ELMOD1
333 transferase activity, transferring one-carbon groups (GO:0016741) 1/218 0.9903507 1 0 0 0.2189573 0.0021230 ALDH1L2
334 GTPase activity (GO:0003924) 1/224 0.9915137 1 0 0 0.2130924 0.0018161 RAB43
335 protein heterodimerization activity (GO:0046982) 3/408 0.9919877 1 0 0 0.3509757 0.0028234 ANO1;IRAK3;ADRA2A
336 nucleoside-triphosphatase regulator activity (GO:0060589) 2/330 0.9928693 1 0 0 0.2892891 0.0020702 ARHGAP40;ELMOD1
337 tubulin binding (GO:0015631) 1/241 0.9941033 1 0 0 0.1980610 0.0011714 JAKMIP3
338 enzyme activator activity (GO:0008047) 3/446 0.9958542 1 0 0 0.3210720 0.0013339 ARHGAP40;ELMOD1;NKX3-1
339 phosphoric ester hydrolase activity (GO:0042578) 2/360 0.9959591 1 0 0 0.2651816 0.0010737 CHRM1;PTPRH
340 phosphatase activity (GO:0016791) 1/266 0.9965494 1 0 0 0.1794462 0.0006203 PTPRH
341 carbohydrate binding (GO:0030246) 1/278 0.9973324 1 0 0 0.1717003 0.0004586 REG4
342 ubiquitin-protein transferase activity (GO:0004842) 1/279 0.9973890 1 0 0 0.1710849 0.0004473 PAX6
343 ATPase activity (GO:0016887) 2/395 0.9979329 1 0 0 0.2416845 0.0005001 RTEL1-TNFRSF6B;ATP10B
344 transcription coactivator activity (GO:0003713) 1/291 0.9979816 1 0 0 0.1640299 0.0003314 SIX3
345 endopeptidase activity (GO:0004175) 2/411 0.9984821 1 0 0 0.2322759 0.0003528 ADAMDEC1;PLAT
346 GTP binding (GO:0005525) 1/385 0.9997308 1 0 0 0.1239810 0.0000334 RAB43
347 guanyl ribonucleotide binding (GO:0032561) 1/405 0.9998241 1 0 0 0.1178585 0.0000207 RAB43
348 guanyl nucleotide binding (GO:0019001) 1/406 0.9998278 1 0 0 0.1175682 0.0000202 RAB43
349 chromatin binding (GO:0003682) 1/420 0.9998719 1 0 0 0.1136493 0.0000146 PAX6
350 ATP binding (GO:0005524) 13/1494 0.9999555 1 0 0 0.4153448 0.0000185 NTRK2;RTEL1-TNFRSF6B;ENTPD2;PNCK;PDPK2;DQX1;NEK6;ATP10B;ENTPD8;FIGN;IRAK3;MYLK3;HKDC1
351 zinc ion binding (GO:0008270) 2/1256 0.9999954 1 0 0 0.0760075 0.0000003 ADAMDEC1;CPE

EnrichR, downregulated genes

## Uploading data to Enrichr... Done.
##   Querying GO_Molecular_Function_2015... Done.
##   Querying GO_Cellular_Component_2015... Done.
##   Querying GO_Biological_Process_2015... Done.
## Parsing results... Done.

GO_Biological_Process_2015

go_biological %>%
  knitr::kable(
    format = "html", align = rep("c", ncol(go_biological) + 1),
    row.names = TRUE
  ) %>%
  kableExtra::kable_styling() %>%
  kableExtra::scroll_box(height = "300px")
Term Overlap P.value Adjusted.P.value Old.P.value Old.Adjusted.P.value Odds.Ratio Combined.Score Genes
1 synaptic transmission (GO:0007268) 14/434 0.0001261 0.6546647 0 0 3.2258065 28.9629235 GABBR2;KCNJ6;GRID1;SLC6A13;KCNA3;KCNA4;GRIK1;SLC5A7;NPBWR1;SNCG;ANXA9;GABRD;KCNJ1;KCNK3
2 macrophage chemotaxis (GO:0048246) 3/14 0.0003306 0.8581617 0 0 21.4285714 171.7433537 CX3CR1;CCL5;SFTPD
3 negative regulation of viral genome replication (GO:0045071) 4/40 0.0006691 1.0000000 0 0 10.0000000 73.0963454 APOBEC3H;CCL5;IFIT1;OASL
4 sprouting angiogenesis (GO:0002040) 3/24 0.0017077 1.0000000 0 0 12.5000000 79.6578471 RAMP2;FLT4;GPR124
5 cellular potassium ion transport (GO:0071804) 6/129 0.0019065 1.0000000 0 0 4.6511628 29.1279537 KCNJ6;CNGA1;KCNA3;KCNA4;KCNJ1;KCNK3
6 potassium ion transmembrane transport (GO:0071805) 6/129 0.0019065 1.0000000 0 0 4.6511628 29.1279537 KCNJ6;CNGA1;KCNA3;KCNA4;KCNJ1;KCNK3
7 positive regulation of vasodilation (GO:0045909) 3/26 0.0021617 1.0000000 0 0 11.5384615 70.8100816 NPPC;GJA1;ALOX12
8 regulation of viral genome replication (GO:0045069) 4/57 0.0025341 1.0000000 0 0 7.0175439 41.9501817 APOBEC3H;CCL5;IFIT1;OASL
9 cytidine deamination (GO:0009972) 2/9 0.0034202 1.0000000 0 0 22.2222222 126.1788209 APOBEC2;APOBEC3H
10 cytidine metabolic process (GO:0046087) 2/9 0.0034202 1.0000000 0 0 22.2222222 126.1788209 APOBEC2;APOBEC3H
11 cytidine catabolic process (GO:0006216) 2/9 0.0034202 1.0000000 0 0 22.2222222 126.1788209 APOBEC2;APOBEC3H
12 potassium ion transport (GO:0006813) 6/151 0.0041682 1.0000000 0 0 3.9735099 21.7758854 KCNJ6;CNGA1;KCNA3;KCNA4;KCNJ1;KCNK3
13 pyrimidine ribonucleoside catabolic process (GO:0046133) 2/10 0.0042472 1.0000000 0 0 20.0000000 109.2297554 APOBEC2;APOBEC3H
14 ethanol oxidation (GO:0006069) 2/11 0.0051570 1.0000000 0 0 18.1818182 95.7708415 ADH1C;ADH1B
15 positive regulation of blood circulation (GO:1903524) 4/72 0.0058778 1.0000000 0 0 5.5555556 28.5365281 NPPC;GJA1;OR51E2;ALOX12
16 male sex determination (GO:0030238) 2/12 0.0061479 1.0000000 0 0 16.6666667 84.8608119 FGF9;DMRT1
17 negative regulation of viral process (GO:0048525) 4/75 0.0067856 1.0000000 0 0 5.3333333 26.6290906 APOBEC3H;CCL5;IFIT1;OASL
18 regulation of vasodilation (GO:0042312) 3/39 0.0069091 1.0000000 0 0 7.6923077 38.2686129 NPPC;GJA1;ALOX12
19 myeloid leukocyte migration (GO:0097529) 4/76 0.0071076 1.0000000 0 0 5.2631579 26.0346606 CX3CR1;PLA2G1B;CCL5;SFTPD
20 ethanol metabolic process (GO:0006067) 2/14 0.0083660 1.0000000 0 0 14.2857143 68.3368024 ADH1C;ADH1B
21 regulation of cellular response to growth factor stimulus (GO:0090287) 6/176 0.0086499 1.0000000 0 0 3.4090909 16.1939003 FGF9;HHIP;PEG10;FGF18;FBN1;GPR124
22 positive regulation of protein dephosphorylation (GO:0035307) 2/16 0.0108884 1.0000000 0 0 12.5000000 56.5006873 DLC1;DUSP26
23 adult heart development (GO:0007512) 2/16 0.0108884 1.0000000 0 0 12.5000000 56.5006873 GJA1;SCUBE1
24 positive regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030949) 2/16 0.0108884 1.0000000 0 0 12.5000000 56.5006873 FGF9;FGF18
25 negative regulation of multi-organism process (GO:0043901) 5/133 0.0109104 1.0000000 0 0 3.7593985 16.9851219 NPPC;APOBEC3H;CCL5;IFIT1;OASL
26 positive regulation of natural killer cell mediated cytotoxicity (GO:0045954) 2/18 0.0137022 1.0000000 0 0 11.1111111 47.6688727 KLRK1;CRTAM
27 regulation of antigen processing and presentation (GO:0002577) 2/18 0.0137022 1.0000000 0 0 11.1111111 47.6688727 HLA-DOA;HLA-DQB2
28 positive regulation of viral genome replication (GO:0045070) 2/18 0.0137022 1.0000000 0 0 11.1111111 47.6688727 CCL5;IFIT1
29 negative regulation of meiotic cell cycle (GO:0051447) 2/18 0.0137022 1.0000000 0 0 11.1111111 47.6688727 NPPC;DMRT1
30 positive regulation of natural killer cell mediated immunity (GO:0002717) 2/19 0.0152144 1.0000000 0 0 10.5263158 44.0579974 KLRK1;CRTAM
31 monovalent inorganic cation transport (GO:0015672) 9/384 0.0154664 1.0000000 0 0 2.3437500 9.7712881 SLC5A7;KCNJ6;KCNA3;SLC4A10;CNGA1;KCNA4;KCNJ1;KCNK3;SLC38A4
32 regulation of T cell activation (GO:0050863) 7/259 0.0156398 1.0000000 0 0 2.7027027 11.2376588 KLRK1;CCL5;SFTPD;TRAC;SCGB1A1;HLA-DOA;HLA-DQB2
33 regulation of protein dephosphorylation (GO:0035304) 2/20 0.0167949 1.0000000 0 0 10.0000000 40.8668071 DLC1;DUSP26
34 regulation of homotypic cell-cell adhesion (GO:0034110) 2/20 0.0167949 1.0000000 0 0 10.0000000 40.8668071 CCL5;ALOX12
35 positive regulation of endothelial cell migration (GO:0010595) 3/55 0.0176581 1.0000000 0 0 5.4545455 22.0176155 FLT4;ALOX12;GPR124
36 leukocyte chemotaxis (GO:0030595) 4/100 0.0180733 1.0000000 0 0 4.0000000 16.0532734 CX3CR1;PLA2G1B;CCL5;SFTPD
37 sex determination (GO:0007530) 2/22 0.0201544 1.0000000 0 0 9.0909091 35.4939443 DMRT1;FGF9
38 pyrimidine nucleoside catabolic process (GO:0046135) 2/22 0.0201544 1.0000000 0 0 9.0909091 35.4939443 APOBEC2;APOBEC3H
39 regulation of tissue remodeling (GO:0034103) 3/58 0.0203229 1.0000000 0 0 5.1724138 20.1517517 MC4R;GJA1;FLT4
40 xenobiotic metabolic process (GO:0006805) 5/156 0.0204245 1.0000000 0 0 3.2051282 12.4712148 CYP2W1;ADH1C;CYP2A13;ADH1B;CYP2F1
41 central nervous system development (GO:0007417) 4/108 0.0232396 1.0000000 0 0 3.7037037 13.9329471 ROBO2;DCX;GRIK1;GPR124
42 ionotropic glutamate receptor signaling pathway (GO:0035235) 2/24 0.0237689 1.0000000 0 0 8.3333333 31.1614659 GRID1;GRIK1
43 regulation of natural killer cell mediated immunity (GO:0002715) 2/24 0.0237689 1.0000000 0 0 8.3333333 31.1614659 KLRK1;CRTAM
44 regulation of natural killer cell mediated cytotoxicity (GO:0042269) 2/24 0.0237689 1.0000000 0 0 8.3333333 31.1614659 KLRK1;CRTAM
45 regulation of smoothened signaling pathway (GO:0008589) 3/63 0.0252289 1.0000000 0 0 4.7619048 17.5226913 FGF9;HHIP;GPC3
46 positive regulation of smoothened signaling pathway (GO:0045880) 2/25 0.0256683 1.0000000 0 0 8.0000000 29.2999902 FGF9;GPC3
47 cellular response to vascular endothelial growth factor stimulus (GO:0035924) 2/25 0.0256683 1.0000000 0 0 8.0000000 29.2999902 RAMP2;FLT4
48 regulation of cell activation (GO:0050865) 9/420 0.0258303 1.0000000 0 0 2.1428571 7.8347273 KLRK1;CCL5;SFTPD;TRAC;SCGB1A1;ALOX12;BPI;HLA-DOA;HLA-DQB2
49 regulation of behavior (GO:0050795) 5/166 0.0258581 1.0000000 0 0 3.0120482 11.0094280 ROBO2;MC4R;GJA1;CCL5;GPR124
50 leukocyte migration (GO:0050900) 6/226 0.0263877 1.0000000 0 0 2.6548673 9.6500647 CX3CR1;PLA2G1B;PROS1;CCL5;SFTPD;JAM2
51 heart development (GO:0007507) 5/167 0.0264476 1.0000000 0 0 2.9940120 10.8760212 GJA1;RAMP2;SCUBE1;HOPX;FBN1
52 regulation of cAMP metabolic process (GO:0030814) 4/113 0.0268800 1.0000000 0 0 3.5398230 12.8013173 MC4R;NPPC;GABBR2;RAMP2
53 positive regulation of cell adhesion (GO:0045785) 5/171 0.0288909 1.0000000 0 0 2.9239766 10.3632401 SMOC2;ECM2;CCL5;ALOX12;DUSP26
54 neuron migration (GO:0001764) 4/116 0.0292190 1.0000000 0 0 3.4482759 12.1825356 GPM6A;GJA1;DCX;FEZF2
55 regulation of cyclic nucleotide biosynthetic process (GO:0030802) 4/116 0.0292190 1.0000000 0 0 3.4482759 12.1825356 MC4R;NPPC;GABBR2;RAMP2
56 angiogenesis (GO:0001525) 6/236 0.0316653 1.0000000 0 0 2.5423729 8.7776301 RAMP2;FGF9;FLT4;FGF18;TBX4;GPR124
57 regulation of purine nucleotide biosynthetic process (GO:1900371) 4/119 0.0316752 1.0000000 0 0 3.3613445 11.6041026 MC4R;NPPC;GABBR2;RAMP2
58 regulation of nucleotide biosynthetic process (GO:0030808) 4/119 0.0316752 1.0000000 0 0 3.3613445 11.6041026 MC4R;NPPC;GABBR2;RAMP2
59 negative regulation of smoothened signaling pathway (GO:0045879) 2/28 0.0317181 1.0000000 0 0 7.1428571 24.6490560 HHIP;GPC3
60 regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947) 2/28 0.0317181 1.0000000 0 0 7.1428571 24.6490560 FGF9;FGF18
61 adherens junction organization (GO:0034332) 3/69 0.0318810 1.0000000 0 0 4.3478261 14.9814966 RAMP2;DLC1;CDH7
62 regulation of cardiac muscle cell proliferation (GO:0060043) 2/29 0.0338475 1.0000000 0 0 6.8965517 23.3509763 GJA1;FGF9
63 anion transport (GO:0006820) 9/443 0.0345974 1.0000000 0 0 2.0316027 6.8342631 GJA1;FABP3;PLA2G1B;SLC6A13;SLC7A14;SLC4A10;GABRD;CLCA4;SLC38A4
64 adherens junction assembly (GO:0034333) 2/31 0.0382674 1.0000000 0 0 6.4516129 21.0526212 RAMP2;DLC1
65 T cell costimulation (GO:0031295) 3/76 0.0406839 1.0000000 0 0 3.9473684 12.6391704 KLRK1;TRAC;HLA-DQB2
66 regulation of smooth muscle cell proliferation (GO:0048660) 3/77 0.0420316 1.0000000 0 0 3.8961039 12.3480501 NPPC;CCL5;ALOX12
67 lymphocyte costimulation (GO:0031294) 3/77 0.0420316 1.0000000 0 0 3.8961039 12.3480501 KLRK1;TRAC;HLA-DQB2
68 regulation of leukocyte activation (GO:0002694) 8/390 0.0428832 1.0000000 0 0 2.0512821 6.4600523 KLRK1;CCL5;SFTPD;TRAC;SCGB1A1;BPI;HLA-DOA;HLA-DQB2
69 neuron recognition (GO:0008038) 2/33 0.0428940 1.0000000 0 0 6.0606061 19.0849967 ROBO2;FEZF2
70 cyclic purine nucleotide metabolic process (GO:0052652) 2/33 0.0428940 1.0000000 0 0 6.0606061 19.0849967 NPPC;RAMP2
71 regulation of cyclic nucleotide metabolic process (GO:0030799) 4/133 0.0447024 1.0000000 0 0 3.0075188 9.3465489 MC4R;NPPC;GABBR2;RAMP2
72 positive regulation of epithelial cell migration (GO:0010634) 3/79 0.0447938 1.0000000 0 0 3.7974684 11.7937443 FLT4;ALOX12;GPR124
73 regulation of membrane depolarization (GO:0003254) 2/34 0.0452816 1.0000000 0 0 5.8823529 18.2050300 GJA1;ALOX12
74 cyclic nucleotide biosynthetic process (GO:0009190) 2/34 0.0452816 1.0000000 0 0 5.8823529 18.2050300 NPPC;RAMP2
75 negative regulation of cell activation (GO:0050866) 4/135 0.0467746 1.0000000 0 0 2.9629630 9.0738214 SFTPD;SCGB1A1;ALOX12;BPI
76 organic anion transport (GO:0015711) 7/328 0.0473149 1.0000000 0 0 2.1341463 6.5111316 GJA1;FABP3;PLA2G1B;SLC6A13;SLC7A14;SLC4A10;SLC38A4
77 defense response to other organism (GO:0098542) 7/328 0.0473149 1.0000000 0 0 2.1341463 6.5111316 APOBEC3H;PLA2G1B;CD207;SFTPD;BPI;IFIT1;OASL
78 pyrimidine-containing compound catabolic process (GO:0072529) 2/35 0.0477172 1.0000000 0 0 5.7142857 17.3855107 APOBEC2;APOBEC3H
79 regulation of cardiac muscle tissue growth (GO:0055021) 2/35 0.0477172 1.0000000 0 0 5.7142857 17.3855107 GJA1;FGF9
80 regulation of endocrine process (GO:0044060) 2/35 0.0477172 1.0000000 0 0 5.7142857 17.3855107 KISS1;OR51E2
81 lung development (GO:0030324) 3/82 0.0491020 1.0000000 0 0 3.6585366 11.0263036 FGF18;GPC3;TBX4
82 positive regulation of cyclic nucleotide biosynthetic process (GO:0030804) 3/82 0.0491020 1.0000000 0 0 3.6585366 11.0263036 MC4R;NPPC;RAMP2
83 synaptic transmission, glutamatergic (GO:0035249) 2/36 0.0501995 1.0000000 0 0 5.5555556 16.6208344 GRID1;GRIK1
84 chemokine-mediated signaling pathway (GO:0070098) 2/36 0.0501995 1.0000000 0 0 5.5555556 16.6208344 CX3CR1;CCL5
85 positive regulation of purine nucleotide biosynthetic process (GO:1900373) 3/84 0.0520826 1.0000000 0 0 3.5714286 10.5532996 MC4R;NPPC;RAMP2
86 post-embryonic development (GO:0009791) 3/84 0.0520826 1.0000000 0 0 3.5714286 10.5532996 NPPC;SCUBE1;KCNJ1
87 positive regulation of nucleotide biosynthetic process (GO:0030810) 3/84 0.0520826 1.0000000 0 0 3.5714286 10.5532996 MC4R;NPPC;RAMP2
88 positive regulation of dephosphorylation (GO:0035306) 2/37 0.0527275 1.0000000 0 0 5.4054054 15.9060490 DLC1;DUSP26
89 leukotriene metabolic process (GO:0006691) 2/37 0.0527275 1.0000000 0 0 5.4054054 15.9060490 PLA2G1B;ALOX12
90 positive regulation of leukocyte mediated cytotoxicity (GO:0001912) 2/37 0.0527275 1.0000000 0 0 5.4054054 15.9060490 KLRK1;CRTAM
91 pyrimidine ribonucleoside metabolic process (GO:0046131) 2/37 0.0527275 1.0000000 0 0 5.4054054 15.9060490 APOBEC2;APOBEC3H
92 sodium ion transport (GO:0006814) 4/141 0.0533069 1.0000000 0 0 2.8368794 8.3168492 SLC5A7;SLC4A10;KCNJ1;SLC38A4
93 regulation of blood circulation (GO:1903522) 5/204 0.0544706 1.0000000 0 0 2.4509804 7.1325851 NPPC;GJA1;OR51E2;ALOX12;HOPX
94 embryonic limb morphogenesis (GO:0030326) 3/86 0.0551489 1.0000000 0 0 3.4883721 10.1083208 FGF9;GPC3;TBX4
95 positive regulation of Wnt signaling pathway (GO:0030177) 3/86 0.0551489 1.0000000 0 0 3.4883721 10.1083208 FGF9;GPC3;LGR5
96 embryonic appendage morphogenesis (GO:0035113) 3/86 0.0551489 1.0000000 0 0 3.4883721 10.1083208 FGF9;GPC3;TBX4
97 regulation of meiotic cell cycle (GO:0051445) 2/38 0.0552999 1.0000000 0 0 5.2631579 15.2367633 NPPC;DMRT1
98 lung alveolus development (GO:0048286) 2/38 0.0552999 1.0000000 0 0 5.2631579 15.2367633 SFTPD;HOPX
99 long-chain fatty acid transport (GO:0015909) 2/38 0.0552999 1.0000000 0 0 5.2631579 15.2367633 FABP3;PLA2G1B
100 regulation of multicellular organismal metabolic process (GO:0044246) 2/39 0.0579156 1.0000000 0 0 5.1282051 14.6090715 MC4R;MFAP4
101 regulation of lymphocyte activation (GO:0051249) 7/344 0.0581823 1.0000000 0 0 2.0348837 5.7875623 KLRK1;CCL5;SFTPD;TRAC;SCGB1A1;HLA-DOA;HLA-DQB2
102 cellular response to interferon-gamma (GO:0071346) 3/88 0.0582996 1.0000000 0 0 3.4090909 9.6891797 CCL5;HLA-DQB2;OASL
103 phototransduction, visible light (GO:0007603) 3/89 0.0599063 1.0000000 0 0 3.3707865 9.4886736 OPN1SW;CNGA1;GPC3
104 defense response to virus (GO:0051607) 4/147 0.0603096 1.0000000 0 0 2.7210884 7.6415355 APOBEC3H;CD207;IFIT1;OASL
105 telencephalon cell migration (GO:0022029) 2/40 0.0605735 1.0000000 0 0 5.0000000 14.0194887 CX3CR1;FEZF2
106 regulation of bone remodeling (GO:0046850) 2/40 0.0605735 1.0000000 0 0 5.0000000 14.0194887 MC4R;GJA1
107 glutamate receptor signaling pathway (GO:0007215) 2/40 0.0605735 1.0000000 0 0 5.0000000 14.0194887 GRID1;GRIK1
108 positive regulation of cyclic nucleotide metabolic process (GO:0030801) 3/91 0.0631816 1.0000000 0 0 3.2967033 9.1046463 MC4R;NPPC;RAMP2
109 chondrocyte differentiation (GO:0002062) 2/41 0.0632725 1.0000000 0 0 4.8780488 13.4648969 NPPC;FGF9
110 primary alcohol metabolic process (GO:0034308) 2/41 0.0632725 1.0000000 0 0 4.8780488 13.4648969 ADH1C;ADH1B
111 negative regulation of behavior (GO:0048521) 2/41 0.0632725 1.0000000 0 0 4.8780488 13.4648969 ROBO2;MC4R
112 regulation of heart growth (GO:0060420) 2/41 0.0632725 1.0000000 0 0 4.8780488 13.4648969 GJA1;FGF9
113 chloride transport (GO:0006821) 3/92 0.0648498 1.0000000 0 0 3.2608696 8.9207002 SLC4A10;GABRD;CLCA4
114 regulation of endothelial cell migration (GO:0010594) 3/92 0.0648498 1.0000000 0 0 3.2608696 8.9207002 FLT4;ALOX12;GPR124
115 response to drug (GO:0042493) 7/354 0.0656994 1.0000000 0 0 1.9774011 5.3838006 NPPC;FABP3;DDC;SCGB1A1;SNCG;KCNK3;ABCG2
116 icosanoid biosynthetic process (GO:0046456) 2/42 0.0660116 1.0000000 0 0 4.7619048 12.9424984 PLA2G1B;ALOX12
117 negative regulation of T cell proliferation (GO:0042130) 2/42 0.0660116 1.0000000 0 0 4.7619048 12.9424984 SFTPD;SCGB1A1
118 fatty acid derivative biosynthetic process (GO:1901570) 2/42 0.0660116 1.0000000 0 0 4.7619048 12.9424984 PLA2G1B;ALOX12
119 positive regulation of cell killing (GO:0031343) 2/42 0.0660116 1.0000000 0 0 4.7619048 12.9424984 KLRK1;CRTAM
120 regulation of viral process (GO:0050792) 4/152 0.0665001 1.0000000 0 0 2.6315789 7.1330304 APOBEC3H;CCL5;IFIT1;OASL
121 forebrain cell migration (GO:0021885) 2/43 0.0687896 1.0000000 0 0 4.6511628 12.4497769 CX3CR1;FEZF2
122 negative regulation of blood coagulation (GO:0030195) 2/43 0.0687896 1.0000000 0 0 4.6511628 12.4497769 PROS1;ALOX12
123 negative regulation of hemostasis (GO:1900047) 2/43 0.0687896 1.0000000 0 0 4.6511628 12.4497769 PROS1;ALOX12
124 cell chemotaxis (GO:0060326) 4/155 0.0703673 1.0000000 0 0 2.5806452 6.8491008 CX3CR1;PLA2G1B;CCL5;SFTPD
125 regulation of leukocyte mediated cytotoxicity (GO:0001910) 2/44 0.0716056 1.0000000 0 0 4.5454545 11.9844629 KLRK1;CRTAM
126 carboxylic acid transport (GO:0046942) 5/224 0.0747953 1.0000000 0 0 2.2321429 5.7879457 FABP3;PLA2G1B;SLC6A13;SLC7A14;SLC38A4
127 regulation of cAMP biosynthetic process (GO:0030817) 3/98 0.0752775 1.0000000 0 0 3.0612245 7.9180831 MC4R;GABBR2;RAMP2
128 protein oligomerization (GO:0051259) 7/366 0.0754631 1.0000000 0 0 1.9125683 4.9422889 GJA1;SCUBE1;CCL5;QPRT;KCNA3;KCNA4;TGM3
129 organic acid transport (GO:0015849) 5/226 0.0770271 1.0000000 0 0 2.2123894 5.6716780 FABP3;PLA2G1B;SLC6A13;SLC7A14;SLC38A4
130 cell junction assembly (GO:0034329) 4/160 0.0770636 1.0000000 0 0 2.5000000 6.4078112 GJA1;RAMP2;DLC1;CDH7
131 T cell receptor signaling pathway (GO:0050852) 3/99 0.0770836 1.0000000 0 0 3.0303030 7.7662575 TRAC;SKAP1;HLA-DQB2
132 positive regulation of male gonad development (GO:2000020) 1/8 0.0772681 1.0000000 0 0 12.5000000 32.0059307 DMRT1
133 activated T cell proliferation (GO:0050798) 1/8 0.0772681 1.0000000 0 0 12.5000000 32.0059307 CRTAM
134 purine ribonucleotide transport (GO:0015868) 1/8 0.0772681 1.0000000 0 0 12.5000000 32.0059307 GJA1
135 endothelium development (GO:0003158) 1/8 0.0772681 1.0000000 0 0 12.5000000 32.0059307 GJA1
136 negative regulation of cytosolic calcium ion concentration (GO:0051481) 1/8 0.0772681 1.0000000 0 0 12.5000000 32.0059307 KCNK3
137 regulation of vascular endothelial growth factor signaling pathway (GO:1900746) 1/8 0.0772681 1.0000000 0 0 12.5000000 32.0059307 GPR124
138 sequestering of extracellular ligand from receptor (GO:0035581) 1/8 0.0772681 1.0000000 0 0 12.5000000 32.0059307 FBN1
139 embryonic process involved in female pregnancy (GO:0060136) 1/8 0.0772681 1.0000000 0 0 12.5000000 32.0059307 ABCG2
140 cell proliferation involved in metanephros development (GO:0072203) 1/8 0.0772681 1.0000000 0 0 12.5000000 32.0059307 GPC3
141 regulation of chemokine-mediated signaling pathway (GO:0070099) 1/8 0.0772681 1.0000000 0 0 12.5000000 32.0059307 CCL5
142 regulation of antigen processing and presentation of peptide antigen (GO:0002583) 1/8 0.0772681 1.0000000 0 0 12.5000000 32.0059307 HLA-DOA
143 regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371) 1/8 0.0772681 1.0000000 0 0 12.5000000 32.0059307 GJA1
144 adenine nucleotide transport (GO:0051503) 1/8 0.0772681 1.0000000 0 0 12.5000000 32.0059307 GJA1
145 substrate-independent telencephalic tangential migration (GO:0021826) 1/8 0.0772681 1.0000000 0 0 12.5000000 32.0059307 FEZF2
146 positive regulation of protein kinase C signaling (GO:0090037) 1/8 0.0772681 1.0000000 0 0 12.5000000 32.0059307 FLT4
147 regulation of meiosis I (GO:0060631) 1/8 0.0772681 1.0000000 0 0 12.5000000 32.0059307 DMRT1
148 positive regulation of growth hormone secretion (GO:0060124) 1/8 0.0772681 1.0000000 0 0 12.5000000 32.0059307 KISS1
149 regulation of activation of Janus kinase activity (GO:0010533) 1/8 0.0772681 1.0000000 0 0 12.5000000 32.0059307 CCL5
150 cellular response to exogenous dsRNA (GO:0071360) 1/8 0.0772681 1.0000000 0 0 12.5000000 32.0059307 IFIT1
151 response to xenobiotic stimulus (GO:0009410) 1/8 0.0772681 1.0000000 0 0 12.5000000 32.0059307 SCGB1A1
152 citrulline biosynthetic process (GO:0019240) 1/8 0.0772681 1.0000000 0 0 12.5000000 32.0059307 PADI3
153 substrate-independent telencephalic tangential interneuron migration (GO:0021843) 1/8 0.0772681 1.0000000 0 0 12.5000000 32.0059307 FEZF2
154 gap junction assembly (GO:0016264) 1/8 0.0772681 1.0000000 0 0 12.5000000 32.0059307 GJA1
155 positive regulation of immune response to tumor cell (GO:0002839) 1/8 0.0772681 1.0000000 0 0 12.5000000 32.0059307 CRTAM
156 regulation of response to tumor cell (GO:0002834) 1/8 0.0772681 1.0000000 0 0 12.5000000 32.0059307 CRTAM
157 regulation of immune response to tumor cell (GO:0002837) 1/8 0.0772681 1.0000000 0 0 12.5000000 32.0059307 CRTAM
158 positive regulation of response to tumor cell (GO:0002836) 1/8 0.0772681 1.0000000 0 0 12.5000000 32.0059307 CRTAM
159 regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091) 1/8 0.0772681 1.0000000 0 0 12.5000000 32.0059307 APOBEC3H
160 positive regulation of muscle organ development (GO:0048636) 2/46 0.0773472 1.0000000 0 0 4.3478261 11.1280460 GJA1;FGF9
161 positive regulation of striated muscle tissue development (GO:0045844) 2/46 0.0773472 1.0000000 0 0 4.3478261 11.1280460 GJA1;FGF9
162 positive regulation of smooth muscle cell proliferation (GO:0048661) 2/46 0.0773472 1.0000000 0 0 4.3478261 11.1280460 CCL5;ALOX12
163 amino acid transmembrane transport (GO:0003333) 2/46 0.0773472 1.0000000 0 0 4.3478261 11.1280460 SLC7A14;SLC38A4
164 cell-cell junction organization (GO:0045216) 4/161 0.0784400 1.0000000 0 0 2.4844720 6.3240267 GJA1;RAMP2;DLC1;CDH7
165 negative regulation of coagulation (GO:0050819) 2/47 0.0802709 1.0000000 0 0 4.2553191 10.7333979 PROS1;ALOX12
166 keratinization (GO:0031424) 2/47 0.0802709 1.0000000 0 0 4.2553191 10.7333979 CNFN;TGM3
167 positive regulation of muscle tissue development (GO:1901863) 2/47 0.0802709 1.0000000 0 0 4.2553191 10.7333979 GJA1;FGF9
168 positive regulation of angiogenesis (GO:0045766) 3/101 0.0807525 1.0000000 0 0 2.9702970 7.4743550 CX3CR1;RAMP2;ALOX12
169 limb morphogenesis (GO:0035108) 3/101 0.0807525 1.0000000 0 0 2.9702970 7.4743550 FGF9;GPC3;TBX4
170 appendage morphogenesis (GO:0035107) 3/101 0.0807525 1.0000000 0 0 2.9702970 7.4743550 FGF9;GPC3;TBX4
171 regulation of cardiac muscle tissue development (GO:0055024) 2/48 0.0832284 1.0000000 0 0 4.1666667 10.3590263 GJA1;FGF9
172 stem cell proliferation (GO:0072089) 2/48 0.0832284 1.0000000 0 0 4.1666667 10.3590263 HHIP;GPC3
173 fatty acid transport (GO:0015908) 2/49 0.0862189 1.0000000 0 0 4.0816327 10.0035323 FABP3;PLA2G1B
174 monocarboxylic acid transport (GO:0015718) 3/104 0.0863951 1.0000000 0 0 2.8846154 7.0639147 FABP3;PLA2G1B;SLC6A13
175 detection of visible light (GO:0009584) 3/104 0.0863951 1.0000000 0 0 2.8846154 7.0639147 OPN1SW;CNGA1;GPC3
176 negative regulation of cellular response to growth factor stimulus (GO:0090288) 3/104 0.0863951 1.0000000 0 0 2.8846154 7.0639147 PEG10;FBN1;GPR124
177 gamma-aminobutyric acid transport (GO:0015812) 1/9 0.0864991 1.0000000 0 0 11.1111111 27.1957962 SLC6A13
178 regulation of chronic inflammatory response (GO:0002676) 1/9 0.0864991 1.0000000 0 0 11.1111111 27.1957962 CCL5
179 heme transport (GO:0015886) 1/9 0.0864991 1.0000000 0 0 11.1111111 27.1957962 ABCG2
180 regulation of gonadotropin secretion (GO:0032276) 1/9 0.0864991 1.0000000 0 0 11.1111111 27.1957962 KISS1
181 alkaloid metabolic process (GO:0009820) 1/9 0.0864991 1.0000000 0 0 11.1111111 27.1957962 DDC
182 lymph vessel development (GO:0001945) 1/9 0.0864991 1.0000000 0 0 11.1111111 27.1957962 FLT4
183 regulation of helicase activity (GO:0051095) 1/9 0.0864991 1.0000000 0 0 11.1111111 27.1957962 IFIT1
184 regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547) 1/9 0.0864991 1.0000000 0 0 11.1111111 27.1957962 GPR124
185 negative regulation of homotypic cell-cell adhesion (GO:0034111) 1/9 0.0864991 1.0000000 0 0 11.1111111 27.1957962 ALOX12
186 regulation of phospholipase A2 activity (GO:0032429) 1/9 0.0864991 1.0000000 0 0 11.1111111 27.1957962 PLA2G1B
187 atrial cardiac muscle cell action potential (GO:0086014) 1/9 0.0864991 1.0000000 0 0 11.1111111 27.1957962 GJA1
188 DNA deamination (GO:0045006) 1/9 0.0864991 1.0000000 0 0 11.1111111 27.1957962 APOBEC3H
189 response to pheromone (GO:0019236) 1/9 0.0864991 1.0000000 0 0 11.1111111 27.1957962 TMEM145
190 opioid receptor signaling pathway (GO:0038003) 1/9 0.0864991 1.0000000 0 0 11.1111111 27.1957962 NPBWR1
191 positive regulation of amino acid transport (GO:0051957) 1/9 0.0864991 1.0000000 0 0 11.1111111 27.1957962 GRIK1
192 eosinophil chemotaxis (GO:0048245) 1/9 0.0864991 1.0000000 0 0 11.1111111 27.1957962 CCL5
193 regulation of multi-organism process (GO:0043900) 6/306 0.0874918 1.0000000 0 0 1.9607843 4.7768817 NPPC;CD8B;APOBEC3H;CCL5;IFIT1;OASL
194 response to fatty acid (GO:0070542) 2/50 0.0892415 1.0000000 0 0 4.0000000 9.6656385 FABP3;OR51E2
195 negative regulation of wound healing (GO:0061045) 2/50 0.0892415 1.0000000 0 0 4.0000000 9.6656385 PROS1;ALOX12
196 regulation of cell killing (GO:0031341) 2/50 0.0892415 1.0000000 0 0 4.0000000 9.6656385 KLRK1;CRTAM
197 positive regulation of protein secretion (GO:0050714) 3/106 0.0902475 1.0000000 0 0 2.8301887 6.8071667 PLA2G1B;CRTAM;OR51E2
198 cell growth (GO:0016049) 3/106 0.0902475 1.0000000 0 0 2.8301887 6.8071667 NDRG4;DCX;EMP1
199 regulation of wound healing (GO:0061041) 3/107 0.0922004 1.0000000 0 0 2.8037383 6.6835268 PROS1;ALOX12;HOPX
200 regulation of response to biotic stimulus (GO:0002831) 3/107 0.0922004 1.0000000 0 0 2.8037383 6.6835268 CD8B;CRTAM;IFIT1
201 unsaturated fatty acid biosynthetic process (GO:0006636) 2/51 0.0922950 1.0000000 0 0 3.9215686 9.3441758 PLA2G1B;ALOX12
202 negative regulation of immune system process (GO:0002683) 6/311 0.0927754 1.0000000 0 0 1.9292605 4.5869588 SFTPD;SCGB1A1;BPI;UBASH3A;IFIT1;HLA-DOA
203 response to other organism (GO:0051707) 8/462 0.0932984 1.0000000 0 0 1.7316017 4.1072776 APOBEC3H;PLA2G1B;CCL5;CD207;SFTPD;BPI;IFIT1;OASL
204 response to interferon-gamma (GO:0034341) 3/108 0.0941707 1.0000000 0 0 2.7777778 6.5629070 CCL5;HLA-DQB2;OASL
205 anion transmembrane transport (GO:0098656) 4/172 0.0943786 1.0000000 0 0 2.3255814 5.4893965 SLC7A14;GABRD;CLCA4;SLC38A4
206 nitrogen compound transport (GO:0071705) 8/464 0.0950459 1.0000000 0 0 1.7241379 4.0575780 MC4R;SLC5A7;GJA1;DDC;SLC6A13;SLC7A14;ABCG2;SLC38A4
207 negative regulation of stress fiber assembly (GO:0051497) 1/10 0.0956382 1.0000000 0 0 10.0000000 23.4718325 DLC1
208 regulation of glomerular filtration (GO:0003093) 1/10 0.0956382 1.0000000 0 0 10.0000000 23.4718325 GJA1
209 regulation of T cell chemotaxis (GO:0010819) 1/10 0.0956382 1.0000000 0 0 10.0000000 23.4718325 CCL5
210 regulation of macrophage chemotaxis (GO:0010758) 1/10 0.0956382 1.0000000 0 0 10.0000000 23.4718325 CCL5
211 positive regulation of T cell chemotaxis (GO:0010820) 1/10 0.0956382 1.0000000 0 0 10.0000000 23.4718325 CCL5
212 cardiovascular system development (GO:0072358) 1/10 0.0956382 1.0000000 0 0 10.0000000 23.4718325 KCNJ1
213 surfactant homeostasis (GO:0043129) 1/10 0.0956382 1.0000000 0 0 10.0000000 23.4718325 SFTPD
214 aggressive behavior (GO:0002118) 1/10 0.0956382 1.0000000 0 0 10.0000000 23.4718325 SNCG
215 negative regulation of cardiac muscle tissue growth (GO:0055022) 1/10 0.0956382 1.0000000 0 0 10.0000000 23.4718325 GJA1
216 purine nucleotide transport (GO:0015865) 1/10 0.0956382 1.0000000 0 0 10.0000000 23.4718325 GJA1
217 positive regulation of endothelial cell differentiation (GO:0045603) 1/10 0.0956382 1.0000000 0 0 10.0000000 23.4718325 ALOX12
218 regulation of tight junction assembly (GO:2000810) 1/10 0.0956382 1.0000000 0 0 10.0000000 23.4718325 GJA1
219 negative regulation of gluconeogenesis (GO:0045721) 1/10 0.0956382 1.0000000 0 0 10.0000000 23.4718325 LEPR
220 phospholipid homeostasis (GO:0055091) 1/10 0.0956382 1.0000000 0 0 10.0000000 23.4718325 FABP3
221 negative regulation of synaptic transmission, glutamatergic (GO:0051967) 1/10 0.0956382 1.0000000 0 0 10.0000000 23.4718325 GRIK1
222 response to insecticide (GO:0017085) 1/10 0.0956382 1.0000000 0 0 10.0000000 23.4718325 DDC
223 positive regulation of vasculogenesis (GO:2001214) 1/10 0.0956382 1.0000000 0 0 10.0000000 23.4718325 RAMP2
224 regulation of male gonad development (GO:2000018) 1/10 0.0956382 1.0000000 0 0 10.0000000 23.4718325 DMRT1
225 eosinophil migration (GO:0072677) 1/10 0.0956382 1.0000000 0 0 10.0000000 23.4718325 CCL5
226 positive regulation of monocyte chemotaxis (GO:0090026) 1/10 0.0956382 1.0000000 0 0 10.0000000 23.4718325 CCL5
227 regulation of mononuclear cell migration (GO:0071675) 1/10 0.0956382 1.0000000 0 0 10.0000000 23.4718325 CCL5
228 regulation of phospholipid biosynthetic process (GO:0071071) 1/10 0.0956382 1.0000000 0 0 10.0000000 23.4718325 FABP3
229 negative regulation of heart growth (GO:0061117) 1/10 0.0956382 1.0000000 0 0 10.0000000 23.4718325 GJA1
230 lymphangiogenesis (GO:0001946) 1/10 0.0956382 1.0000000 0 0 10.0000000 23.4718325 FLT4
231 resolution of meiotic recombination intermediates (GO:0000712) 1/10 0.0956382 1.0000000 0 0 10.0000000 23.4718325 MEIOB
232 long-chain fatty acid biosynthetic process (GO:0042759) 1/10 0.0956382 1.0000000 0 0 10.0000000 23.4718325 ALOX12
233 regulation of ion transmembrane transport (GO:0034765) 6/314 0.0960269 1.0000000 0 0 1.9108280 4.4773126 GJA1;KCNJ6;KCNA3;KCNA4;KCNJ1;KCNK3
234 phototransduction (GO:0007602) 3/109 0.0961583 1.0000000 0 0 2.7522936 6.4452104 OPN1SW;CNGA1;GPC3
235 cell recognition (GO:0008037) 3/109 0.0961583 1.0000000 0 0 2.7522936 6.4452104 ROBO2;CRTAM;FEZF2
236 regulation of symbiosis, encompassing mutualism through parasitism (GO:0043903) 4/174 0.0974299 1.0000000 0 0 2.2988506 5.3531543 APOBEC3H;CCL5;IFIT1;OASL
237 negative regulation of lymphocyte proliferation (GO:0050672) 2/53 0.0984918 1.0000000 0 0 3.7735849 8.7463472 SFTPD;SCGB1A1
238 negative regulation of mononuclear cell proliferation (GO:0032945) 2/53 0.0984918 1.0000000 0 0 3.7735849 8.7463472 SFTPD;SCGB1A1
239 granulocyte chemotaxis (GO:0071621) 2/53 0.0984918 1.0000000 0 0 3.7735849 8.7463472 PLA2G1B;CCL5
240 fatty acid biosynthetic process (GO:0006633) 3/111 0.1001846 1.0000000 0 0 2.7027027 6.2182191 CH25H;PLA2G1B;ALOX12
241 cytosolic calcium ion homeostasis (GO:0051480) 4/176 0.1005270 1.0000000 0 0 2.2727273 5.2212019 KISS1;CD52;GJA1;KCNK3
242 response to insulin (GO:0032868) 5/246 0.1012805 1.0000000 0 0 2.0325203 4.6541895 MC4R;FABP3;FGF9;PLA2G1B;FGF18
243 pyrimidine nucleoside metabolic process (GO:0006213) 2/54 0.1016332 1.0000000 0 0 3.7037037 8.4680937 APOBEC2;APOBEC3H
244 negative regulation of vascular permeability (GO:0043116) 1/11 0.1046863 1.0000000 0 0 9.0909091 20.5162457 RAMP2
245 negative regulation of meiosis (GO:0045835) 1/11 0.1046863 1.0000000 0 0 9.0909091 20.5162457 DMRT1
246 regulation of timing of cell differentiation (GO:0048505) 1/11 0.1046863 1.0000000 0 0 9.0909091 20.5162457 FGF9
247 receptor guanylyl cyclase signaling pathway (GO:0007168) 1/11 0.1046863 1.0000000 0 0 9.0909091 20.5162457 NPPC
248 negative regulation of Rho protein signal transduction (GO:0035024) 1/11 0.1046863 1.0000000 0 0 9.0909091 20.5162457 DLC1
249 dopamine biosynthetic process (GO:0042416) 1/11 0.1046863 1.0000000 0 0 9.0909091 20.5162457 DDC
250 nephron epithelium morphogenesis (GO:0072088) 1/11 0.1046863 1.0000000 0 0 9.0909091 20.5162457 GPC3
251 nephron tubule morphogenesis (GO:0072078) 1/11 0.1046863 1.0000000 0 0 9.0909091 20.5162457 GPC3
252 regulation of growth hormone secretion (GO:0060123) 1/11 0.1046863 1.0000000 0 0 9.0909091 20.5162457 KISS1
253 lung-associated mesenchyme development (GO:0060484) 1/11 0.1046863 1.0000000 0 0 9.0909091 20.5162457 FGF9
254 regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095) 1/11 0.1046863 1.0000000 0 0 9.0909091 20.5162457 GPC3
255 germ cell migration (GO:0008354) 1/11 0.1046863 1.0000000 0 0 9.0909091 20.5162457 DMRT1
256 response to folic acid (GO:0051593) 1/11 0.1046863 1.0000000 0 0 9.0909091 20.5162457 ABCG2
257 serotonin metabolic process (GO:0042428) 1/11 0.1046863 1.0000000 0 0 9.0909091 20.5162457 DDC
258 cell proliferation involved in kidney development (GO:0072111) 1/11 0.1046863 1.0000000 0 0 9.0909091 20.5162457 GPC3
259 mRNA modification (GO:0016556) 1/11 0.1046863 1.0000000 0 0 9.0909091 20.5162457 APOBEC2
260 skeletal muscle tissue regeneration (GO:0043403) 1/11 0.1046863 1.0000000 0 0 9.0909091 20.5162457 GJA1
261 basement membrane organization (GO:0071711) 1/11 0.1046863 1.0000000 0 0 9.0909091 20.5162457 RAMP2
262 granulocyte migration (GO:0097530) 2/55 0.1048020 1.0000000 0 0 3.6363636 8.2024799 PLA2G1B;CCL5
263 regulation of angiogenesis (GO:0045765) 4/179 0.1052574 1.0000000 0 0 2.2346369 5.0309424 CX3CR1;RAMP2;ALOX12;GPR124
264 neuropeptide signaling pathway (GO:0007218) 3/114 0.1063488 1.0000000 0 0 2.6315789 5.8974502 NPBWR1;SCG5;GPR124
265 response to virus (GO:0009615) 5/250 0.1065424 1.0000000 0 0 2.0000000 4.4784239 APOBEC3H;CCL5;CD207;IFIT1;OASL
266 negative regulation of leukocyte proliferation (GO:0070664) 2/56 0.1079976 1.0000000 0 0 3.5714286 7.9487379 SFTPD;SCGB1A1
267 regulation of transmembrane transport (GO:0034762) 6/327 0.1108102 1.0000000 0 0 1.8348624 4.0365800 GJA1;KCNJ6;KCNA3;KCNA4;KCNJ1;KCNK3
268 neurotransmitter secretion (GO:0007269) 2/57 0.1112189 1.0000000 0 0 3.5087719 7.7061583 SLC5A7;SLC6A13
269 UV protection (GO:0009650) 1/12 0.1136443 1.0000000 0 0 8.3333333 18.1223455 MFAP4
270 microglial cell activation (GO:0001774) 1/12 0.1136443 1.0000000 0 0 8.3333333 18.1223455 CX3CR1
271 extracellular fibril organization (GO:0043206) 1/12 0.1136443 1.0000000 0 0 8.3333333 18.1223455 MFAP4
272 chemical homeostasis within a tissue (GO:0048875) 1/12 0.1136443 1.0000000 0 0 8.3333333 18.1223455 SFTPD
273 peptidyl-glutamic acid carboxylation (GO:0017187) 1/12 0.1136443 1.0000000 0 0 8.3333333 18.1223455 PROS1
274 regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307) 1/12 0.1136443 1.0000000 0 0 8.3333333 18.1223455 GJA1
275 regulation of interleukin-13 production (GO:0032656) 1/12 0.1136443 1.0000000 0 0 8.3333333 18.1223455 SCGB1A1
276 positive regulation of synaptic transmission, GABAergic (GO:0032230) 1/12 0.1136443 1.0000000 0 0 8.3333333 18.1223455 GRIK1
277 citrulline metabolic process (GO:0000052) 1/12 0.1136443 1.0000000 0 0 8.3333333 18.1223455 PADI3
278 positive regulation of T cell apoptotic process (GO:0070234) 1/12 0.1136443 1.0000000 0 0 8.3333333 18.1223455 CCL5
279 iron coordination entity transport (GO:1901678) 1/12 0.1136443 1.0000000 0 0 8.3333333 18.1223455 ABCG2
280 regulation of development, heterochronic (GO:0040034) 1/12 0.1136443 1.0000000 0 0 8.3333333 18.1223455 FGF9
281 response to water (GO:0009415) 1/12 0.1136443 1.0000000 0 0 8.3333333 18.1223455 SNCG
282 neutrophil mediated immunity (GO:0002446) 1/12 0.1136443 1.0000000 0 0 8.3333333 18.1223455 PLA2G1B
283 regulation of platelet aggregation (GO:0090330) 1/12 0.1136443 1.0000000 0 0 8.3333333 18.1223455 ALOX12
284 toxin metabolic process (GO:0009404) 1/12 0.1136443 1.0000000 0 0 8.3333333 18.1223455 DDC
285 negative regulation by host of viral transcription (GO:0043922) 1/12 0.1136443 1.0000000 0 0 8.3333333 18.1223455 CCL5
286 body morphogenesis (GO:0010171) 1/12 0.1136443 1.0000000 0 0 8.3333333 18.1223455 GPC3
287 protein carboxylation (GO:0018214) 1/12 0.1136443 1.0000000 0 0 8.3333333 18.1223455 PROS1
288 linoleic acid metabolic process (GO:0043651) 1/12 0.1136443 1.0000000 0 0 8.3333333 18.1223455 ALOX12
289 synapsis (GO:0007129) 1/12 0.1136443 1.0000000 0 0 8.3333333 18.1223455 MEIOB
290 neuron-neuron synaptic transmission (GO:0007270) 2/58 0.1144652 1.0000000 0 0 3.4482759 7.4740853 GRID1;GRIK1
291 cyclic nucleotide metabolic process (GO:0009187) 2/58 0.1144652 1.0000000 0 0 3.4482759 7.4740853 NPPC;RAMP2
292 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway (GO:0090092) 4/186 0.1166797 1.0000000 0 0 2.1505376 4.6200488 DMRT1;PEG10;GPC3;FBN1
293 positive regulation of canonical Wnt signaling pathway (GO:0090263) 2/59 0.1177356 1.0000000 0 0 3.3898305 7.2519111 FGF9;LGR5
294 response to fibroblast growth factor (GO:0071774) 4/187 0.1183543 1.0000000 0 0 2.1390374 4.5648613 FGF9;CCL5;FGF18;SCGB1A1
295 regulation of chemotaxis (GO:0050920) 3/120 0.1191064 1.0000000 0 0 2.5000000 5.3193443 ROBO2;CCL5;GPR124
296 negative regulation of leukocyte activation (GO:0002695) 3/120 0.1191064 1.0000000 0 0 2.5000000 5.3193443 SFTPD;SCGB1A1;BPI
297 regulation of amine transport (GO:0051952) 2/60 0.1210294 1.0000000 0 0 3.3333333 7.0390725 SNCG;GRIK1
298 detection of light stimulus (GO:0009583) 3/121 0.1212860 1.0000000 0 0 2.4793388 5.2304234 OPN1SW;CNGA1;GPC3
299 cellular calcium ion homeostasis (GO:0006874) 5/261 0.1216875 1.0000000 0 0 1.9157088 4.0350552 KISS1;CD52;GJA1;CCL5;KCNK3
300 regulation of cell adhesion (GO:0030155) 6/336 0.1216895 1.0000000 0 0 1.7857143 3.7612194 SMOC2;ECM2;CCL5;ALOX12;DUSP26;JAM2
301 cell junction organization (GO:0034330) 4/189 0.1217348 1.0000000 0 0 2.1164021 4.4569531 GJA1;RAMP2;DLC1;CDH7
302 positive regulation of T cell activation (GO:0050870) 4/189 0.1217348 1.0000000 0 0 2.1164021 4.4569531 KLRK1;CCL5;TRAC;HLA-DQB2
303 positive regulation of antigen processing and presentation (GO:0002579) 1/13 0.1225132 1.0000000 0 0 7.6923077 16.1502800 HLA-DQB2
304 primary amino compound metabolic process (GO:1901160) 1/13 0.1225132 1.0000000 0 0 7.6923077 16.1502800 DDC
305 chronic inflammatory response (GO:0002544) 1/13 0.1225132 1.0000000 0 0 7.6923077 16.1502800 GJA1
306 negative regulation of actin filament bundle assembly (GO:0032232) 1/13 0.1225132 1.0000000 0 0 7.6923077 16.1502800 DLC1
307 mesenchymal cell proliferation (GO:0010463) 1/13 0.1225132 1.0000000 0 0 7.6923077 16.1502800 GPC3
308 peptidyl-proline hydroxylation (GO:0019511) 1/13 0.1225132 1.0000000 0 0 7.6923077 16.1502800 P4HA3
309 urate metabolic process (GO:0046415) 1/13 0.1225132 1.0000000 0 0 7.6923077 16.1502800 ABCG2
310 oocyte development (GO:0048599) 1/13 0.1225132 1.0000000 0 0 7.6923077 16.1502800 DMRT1
311 macrophage activation involved in immune response (GO:0002281) 1/13 0.1225132 1.0000000 0 0 7.6923077 16.1502800 CX3CR1
312 protein-chromophore linkage (GO:0018298) 1/13 0.1225132 1.0000000 0 0 7.6923077 16.1502800 OPN1SW
313 lipoxygenase pathway (GO:0019372) 1/13 0.1225132 1.0000000 0 0 7.6923077 16.1502800 ALOX12
314 regulation of cell maturation (GO:1903429) 1/13 0.1225132 1.0000000 0 0 7.6923077 16.1502800 NPPC
315 regulation of inhibitory postsynaptic membrane potential (GO:0060080) 1/13 0.1225132 1.0000000 0 0 7.6923077 16.1502800 GRIK1
316 renal absorption (GO:0070293) 1/13 0.1225132 1.0000000 0 0 7.6923077 16.1502800 KCNJ1
317 positive regulation of translational initiation (GO:0045948) 1/13 0.1225132 1.0000000 0 0 7.6923077 16.1502800 CCL5
318 vascular endothelial growth factor signaling pathway (GO:0038084) 1/13 0.1225132 1.0000000 0 0 7.6923077 16.1502800 FLT4
319 kidney development (GO:0001822) 3/122 0.1234802 1.0000000 0 0 2.4590164 5.1434622 ROBO2;KCNJ1;FBN1
320 regulation of immune effector process (GO:0002697) 5/264 0.1259849 1.0000000 0 0 1.8939394 3.9234726 KLRK1;CD8B;PROS1;CRTAM;IFIT1
321 signal release (GO:0023061) 3/124 0.1279118 1.0000000 0 0 2.4193548 4.9751966 MC4R;SLC5A7;SLC6A13
322 cytokine-mediated signaling pathway (GO:0019221) 6/342 0.1292261 1.0000000 0 0 1.7543860 3.5898106 CX3CR1;CCL5;LEPR;IFIT1;HLA-DQB2;OASL
323 regulation of T cell proliferation (GO:0042129) 3/125 0.1301487 1.0000000 0 0 2.4000000 4.8937858 CCL5;SFTPD;SCGB1A1
324 regulation of vasculogenesis (GO:2001212) 1/14 0.1312938 1.0000000 0 0 7.1428571 14.5022708 RAMP2
325 cell communication by electrical coupling (GO:0010644) 1/14 0.1312938 1.0000000 0 0 7.1428571 14.5022708 GJA1
326 superoxide anion generation (GO:0042554) 1/14 0.1312938 1.0000000 0 0 7.1428571 14.5022708 ALOX12
327 regulation of endothelial cell differentiation (GO:0045601) 1/14 0.1312938 1.0000000 0 0 7.1428571 14.5022708 ALOX12
328 regulation of non-canonical Wnt signaling pathway (GO:2000050) 1/14 0.1312938 1.0000000 0 0 7.1428571 14.5022708 GPC3
329 regulation of feeding behavior (GO:0060259) 1/14 0.1312938 1.0000000 0 0 7.1428571 14.5022708 MC4R
330 positive regulation of bone resorption (GO:0045780) 1/14 0.1312938 1.0000000 0 0 7.1428571 14.5022708 MC4R
331 arachidonic acid secretion (GO:0050482) 1/14 0.1312938 1.0000000 0 0 7.1428571 14.5022708 PLA2G1B
332 positive regulation of meiosis (GO:0045836) 1/14 0.1312938 1.0000000 0 0 7.1428571 14.5022708 DMRT1
333 Sertoli cell development (GO:0060009) 1/14 0.1312938 1.0000000 0 0 7.1428571 14.5022708 DMRT1
334 fibril organization (GO:0097435) 1/14 0.1312938 1.0000000 0 0 7.1428571 14.5022708 MFAP4
335 positive regulation of bone remodeling (GO:0046852) 1/14 0.1312938 1.0000000 0 0 7.1428571 14.5022708 MC4R
336 regulation of monocyte chemotaxis (GO:0090025) 1/14 0.1312938 1.0000000 0 0 7.1428571 14.5022708 CCL5
337 peptidyl-arginine modification (GO:0018195) 1/14 0.1312938 1.0000000 0 0 7.1428571 14.5022708 PADI3
338 icosanoid secretion (GO:0032309) 1/14 0.1312938 1.0000000 0 0 7.1428571 14.5022708 PLA2G1B
339 cellular response to zinc ion (GO:0071294) 1/14 0.1312938 1.0000000 0 0 7.1428571 14.5022708 KCNK3
340 negative regulation of interleukin-8 production (GO:0032717) 1/14 0.1312938 1.0000000 0 0 7.1428571 14.5022708 BPI
341 negative regulation of T cell receptor signaling pathway (GO:0050860) 1/14 0.1312938 1.0000000 0 0 7.1428571 14.5022708 UBASH3A
342 regulation of dephosphorylation (GO:0035303) 3/126 0.1323995 1.0000000 0 0 2.3809524 4.8141217 DLC1;SLC7A14;DUSP26
343 fatty acid oxidation (GO:0019395) 2/64 0.1344226 1.0000000 0 0 3.1250000 6.2711468 ACOXL;ALOX12
344 inorganic anion transport (GO:0015698) 3/127 0.1346640 1.0000000 0 0 2.3622047 4.7361558 SLC4A10;GABRD;CLCA4
345 antigen receptor-mediated signaling pathway (GO:0050851) 3/127 0.1346640 1.0000000 0 0 2.3622047 4.7361558 TRAC;SKAP1;HLA-DQB2
346 regulation of vasculature development (GO:1901342) 4/197 0.1356621 1.0000000 0 0 2.0304569 4.0560163 CX3CR1;RAMP2;ALOX12;GPR124
347 cellular divalent inorganic cation homeostasis (GO:0072503) 5/271 0.1362797 1.0000000 0 0 1.8450185 3.6772068 KISS1;CD52;GJA1;CCL5;KCNK3
348 amino acid transport (GO:0006865) 3/128 0.1369418 1.0000000 0 0 2.3437500 4.6598412 SLC6A13;SLC7A14;SLC38A4
349 lipid oxidation (GO:0034440) 2/65 0.1378216 1.0000000 0 0 3.0769231 6.0978319 ACOXL;ALOX12
350 cellular response to type I interferon (GO:0071357) 2/65 0.1378216 1.0000000 0 0 3.0769231 6.0978319 IFIT1;OASL
351 positive regulation of cAMP biosynthetic process (GO:0030819) 2/65 0.1378216 1.0000000 0 0 3.0769231 6.0978319 MC4R;RAMP2
352 interferon-gamma-mediated signaling pathway (GO:0060333) 2/65 0.1378216 1.0000000 0 0 3.0769231 6.0978319 HLA-DQB2;OASL
353 type I interferon signaling pathway (GO:0060337) 2/65 0.1378216 1.0000000 0 0 3.0769231 6.0978319 IFIT1;OASL
354 regulation of epithelial cell migration (GO:0010632) 3/129 0.1392329 1.0000000 0 0 2.3255814 4.5851326 FLT4;ALOX12;GPR124
355 positive regulation of secretion (GO:0051047) 5/273 0.1392883 1.0000000 0 0 1.8315018 3.6102742 KISS1;PLA2G1B;CRTAM;OR51E2;GRIK1
356 regulation of mitochondrial depolarization (GO:0051900) 1/15 0.1399869 1.0000000 0 0 6.6666667 13.1080425 ALOX12
357 chondrocyte development (GO:0002063) 1/15 0.1399869 1.0000000 0 0 6.6666667 13.1080425 FGF18
358 cellular response to dsRNA (GO:0071359) 1/15 0.1399869 1.0000000 0 0 6.6666667 13.1080425 IFIT1
359 extracellular matrix assembly (GO:0085029) 1/15 0.1399869 1.0000000 0 0 6.6666667 13.1080425 MFAP4
360 extracellular negative regulation of signal transduction (GO:1900116) 1/15 0.1399869 1.0000000 0 0 6.6666667 13.1080425 FBN1
361 DNA demethylation (GO:0080111) 1/15 0.1399869 1.0000000 0 0 6.6666667 13.1080425 APOBEC2
362 positive regulation of lymphocyte apoptotic process (GO:0070230) 1/15 0.1399869 1.0000000 0 0 6.6666667 13.1080425 CCL5
363 renal tubule morphogenesis (GO:0061333) 1/15 0.1399869 1.0000000 0 0 6.6666667 13.1080425 GPC3
364 positive regulation of smooth muscle cell migration (GO:0014911) 1/15 0.1399869 1.0000000 0 0 6.6666667 13.1080425 CCL5
365 positive regulation of meiotic cell cycle (GO:0051446) 1/15 0.1399869 1.0000000 0 0 6.6666667 13.1080425 DMRT1
366 extracellular regulation of signal transduction (GO:1900115) 1/15 0.1399869 1.0000000 0 0 6.6666667 13.1080425 FBN1
367 positive regulation of T-helper 1 type immune response (GO:0002827) 1/15 0.1399869 1.0000000 0 0 6.6666667 13.1080425 HLA-DQB2
368 renal system process involved in regulation of blood volume (GO:0001977) 1/15 0.1399869 1.0000000 0 0 6.6666667 13.1080425 GJA1
369 regulation of interleukin-5 production (GO:0032674) 1/15 0.1399869 1.0000000 0 0 6.6666667 13.1080425 SCGB1A1
370 dicarboxylic acid catabolic process (GO:0043649) 1/15 0.1399869 1.0000000 0 0 6.6666667 13.1080425 QPRT
371 negative regulation of platelet activation (GO:0010544) 1/15 0.1399869 1.0000000 0 0 6.6666667 13.1080425 ALOX12
372 negative regulation of interleukin-2 production (GO:0032703) 1/15 0.1399869 1.0000000 0 0 6.6666667 13.1080425 SFTPD
373 response to UV-B (GO:0010224) 1/15 0.1399869 1.0000000 0 0 6.6666667 13.1080425 MFAP4
374 nucleoside transport (GO:0015858) 1/15 0.1399869 1.0000000 0 0 6.6666667 13.1080425 GJA1
375 calcium ion homeostasis (GO:0055074) 5/274 0.1408035 1.0000000 0 0 1.8248175 3.5773538 KISS1;CD52;GJA1;CCL5;KCNK3
376 response to type I interferon (GO:0034340) 2/66 0.1412394 1.0000000 0 0 3.0303030 5.9312088 IFIT1;OASL
377 response to acid chemical (GO:0001101) 5/275 0.1423260 1.0000000 0 0 1.8181818 3.5447908 FABP3;OR51E2;SCGB1A1;SNCG;ABCG2
378 negative regulation of hydrolase activity (GO:0051346) 6/354 0.1449554 1.0000000 0 0 1.6949153 3.2734398 PROS1;SLC7A14;GPC3;LEPR;A2ML1;IFIT1
379 nervous system development (GO:0007399) 5/277 0.1453926 1.0000000 0 0 1.8050542 3.4807180 BEX1;DOK5;FGF18;DCX;GRIK1
380 regulation of developmental growth (GO:0048638) 3/133 0.1485253 1.0000000 0 0 2.2556391 4.3015042 GJA1;FGF9;HOPX
381 protein hydroxylation (GO:0018126) 1/16 0.1485935 1.0000000 0 0 6.2500000 11.9158813 P4HA3
382 positive regulation of cell adhesion mediated by integrin (GO:0033630) 1/16 0.1485935 1.0000000 0 0 6.2500000 11.9158813 CCL5
383 phosphatidylinositol acyl-chain remodeling (GO:0036149) 1/16 0.1485935 1.0000000 0 0 6.2500000 11.9158813 PLA2G1B
384 dentate gyrus development (GO:0021542) 1/16 0.1485935 1.0000000 0 0 6.2500000 11.9158813 FEZF2
385 cAMP biosynthetic process (GO:0006171) 1/16 0.1485935 1.0000000 0 0 6.2500000 11.9158813 RAMP2
386 epithelial cell maturation (GO:0002070) 1/16 0.1485935 1.0000000 0 0 6.2500000 11.9158813 GJA1
387 cochlea development (GO:0090102) 1/16 0.1485935 1.0000000 0 0 6.2500000 11.9158813 KCNK3
388 negative regulation of cardiac muscle tissue development (GO:0055026) 1/16 0.1485935 1.0000000 0 0 6.2500000 11.9158813 GJA1
389 behavioral response to pain (GO:0048266) 1/16 0.1485935 1.0000000 0 0 6.2500000 11.9158813 GRIK1
390 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway (GO:0051482) 1/16 0.1485935 1.0000000 0 0 6.2500000 11.9158813 KISS1
391 negative regulation of defense response to virus (GO:0050687) 1/16 0.1485935 1.0000000 0 0 6.2500000 11.9158813 IFIT1
392 establishment of skin barrier (GO:0061436) 1/16 0.1485935 1.0000000 0 0 6.2500000 11.9158813 ALOX12
393 myeloid leukocyte mediated immunity (GO:0002444) 1/16 0.1485935 1.0000000 0 0 6.2500000 11.9158813 PLA2G1B
394 regulation of protein kinase C signaling (GO:0090036) 1/16 0.1485935 1.0000000 0 0 6.2500000 11.9158813 FLT4
395 neuroblast proliferation (GO:0007405) 1/16 0.1485935 1.0000000 0 0 6.2500000 11.9158813 HHIP
396 cGMP biosynthetic process (GO:0006182) 1/16 0.1485935 1.0000000 0 0 6.2500000 11.9158813 NPPC
397 drug transmembrane transport (GO:0006855) 1/16 0.1485935 1.0000000 0 0 6.2500000 11.9158813 ABCG2
398 dendritic cell chemotaxis (GO:0002407) 1/16 0.1485935 1.0000000 0 0 6.2500000 11.9158813 CCL5
399 multicellular organismal aging (GO:0010259) 1/16 0.1485935 1.0000000 0 0 6.2500000 11.9158813 DDC
400 regulation of lymphocyte chemotaxis (GO:1901623) 1/16 0.1485935 1.0000000 0 0 6.2500000 11.9158813 CCL5
401 respiratory burst (GO:0045730) 1/16 0.1485935 1.0000000 0 0 6.2500000 11.9158813 CD52
402 fatty acid metabolic process (GO:0006631) 5/280 0.1500455 1.0000000 0 0 1.7857143 3.3871721 CH25H;FABP3;ACOXL;PLA2G1B;ALOX12
403 positive regulation of lymphocyte mediated immunity (GO:0002708) 2/69 0.1515988 1.0000000 0 0 2.8985507 5.4681675 KLRK1;CRTAM
404 extracellular matrix organization (GO:0030198) 6/359 0.1517582 1.0000000 0 0 1.6713092 3.1511980 SMOC2;MFAP4;RAMP2;ECM2;JAM2;FBN1
405 inorganic cation transmembrane transport (GO:0098662) 7/440 0.1531269 1.0000000 0 0 1.5909091 2.9853222 GPM6A;KCNJ6;KCNA3;CNGA1;KCNA4;KCNJ1;KCNK3
406 extracellular structure organization (GO:0043062) 6/360 0.1531358 1.0000000 0 0 1.6666667 3.1273836 SMOC2;MFAP4;RAMP2;ECM2;JAM2;FBN1
407 cellular metal ion homeostasis (GO:0006875) 6/361 0.1545190 1.0000000 0 0 1.6620499 3.1037753 KISS1;CD52;GJA1;CCL5;KCNK3;ABCG2
408 leukocyte mediated immunity (GO:0002443) 2/70 0.1550849 1.0000000 0 0 2.8571429 5.3250926 PLA2G1B;CRTAM
409 phosphatidylglycerol acyl-chain remodeling (GO:0036148) 1/17 0.1571144 1.0000000 0 0 5.8823529 10.8869493 PLA2G1B
410 forebrain neuron development (GO:0021884) 1/17 0.1571144 1.0000000 0 0 5.8823529 10.8869493 ROBO2
411 male meiosis I (GO:0007141) 1/17 0.1571144 1.0000000 0 0 5.8823529 10.8869493 MEIOB
412 trophectodermal cell differentiation (GO:0001829) 1/17 0.1571144 1.0000000 0 0 5.8823529 10.8869493 HOPX
413 phosphatidylserine acyl-chain remodeling (GO:0036150) 1/17 0.1571144 1.0000000 0 0 5.8823529 10.8869493 PLA2G1B
414 synaptic transmission, cholinergic (GO:0007271) 1/17 0.1571144 1.0000000 0 0 5.8823529 10.8869493 SLC5A7
415 fatty acid derivative transport (GO:1901571) 1/17 0.1571144 1.0000000 0 0 5.8823529 10.8869493 PLA2G1B
416 NAD biosynthetic process (GO:0009435) 1/17 0.1571144 1.0000000 0 0 5.8823529 10.8869493 QPRT
417 monocyte chemotaxis (GO:0002548) 1/17 0.1571144 1.0000000 0 0 5.8823529 10.8869493 CCL5
418 icosanoid transport (GO:0071715) 1/17 0.1571144 1.0000000 0 0 5.8823529 10.8869493 PLA2G1B
419 sex differentiation (GO:0007548) 1/17 0.1571144 1.0000000 0 0 5.8823529 10.8869493 DMRT1
420 neurotransmitter biosynthetic process (GO:0042136) 1/17 0.1571144 1.0000000 0 0 5.8823529 10.8869493 SLC5A7
421 regulation of G-protein coupled receptor protein signaling pathway (GO:0008277) 3/137 0.1580124 1.0000000 0 0 2.1897810 4.0403245 RAMP2;CCL5;CNGA1
422 positive regulation of developmental growth (GO:0048639) 2/71 0.1585864 1.0000000 0 0 2.8169014 5.1871985 FGF9;HOPX
423 renal system process (GO:0003014) 2/71 0.1585864 1.0000000 0 0 2.8169014 5.1871985 GJA1;KCNJ1
424 response to peptide hormone (GO:0043434) 6/364 0.1587019 1.0000000 0 0 1.6483516 3.0341663 MC4R;GJA1;FABP3;FGF9;PLA2G1B;FGF18
425 DNA modification (GO:0006304) 2/72 0.1621027 1.0000000 0 0 2.7777778 5.0542366 APOBEC2;APOBEC3H
426 positive regulation of cAMP metabolic process (GO:0030816) 2/72 0.1621027 1.0000000 0 0 2.7777778 5.0542366 MC4R;RAMP2
427 positive regulation of peptidase activity (GO:0010952) 3/139 0.1628250 1.0000000 0 0 2.1582734 3.9174379 PCOLCE2;DLC1;ALOX12
428 negative regulation of antigen receptor-mediated signaling pathway (GO:0050858) 1/18 0.1655504 1.0000000 0 0 5.5555556 9.9915545 UBASH3A
429 axonal fasciculation (GO:0007413) 1/18 0.1655504 1.0000000 0 0 5.5555556 9.9915545 FEZF2
430 indolalkylamine metabolic process (GO:0006586) 1/18 0.1655504 1.0000000 0 0 5.5555556 9.9915545 DDC
431 embryonic digestive tract development (GO:0048566) 1/18 0.1655504 1.0000000 0 0 5.5555556 9.9915545 FGF9
432 positive regulation of cGMP biosynthetic process (GO:0030828) 1/18 0.1655504 1.0000000 0 0 5.5555556 9.9915545 NPPC
433 catechol-containing compound biosynthetic process (GO:0009713) 1/18 0.1655504 1.0000000 0 0 5.5555556 9.9915545 DDC
434 negative regulation of T cell apoptotic process (GO:0070233) 1/18 0.1655504 1.0000000 0 0 5.5555556 9.9915545 CCL5
435 catecholamine biosynthetic process (GO:0042423) 1/18 0.1655504 1.0000000 0 0 5.5555556 9.9915545 DDC
436 regulation of dopamine secretion (GO:0014059) 1/18 0.1655504 1.0000000 0 0 5.5555556 9.9915545 SNCG
437 fibrinolysis (GO:0042730) 1/18 0.1655504 1.0000000 0 0 5.5555556 9.9915545 PROS1
438 positive regulation of chondrocyte differentiation (GO:0032332) 1/18 0.1655504 1.0000000 0 0 5.5555556 9.9915545 FGF18
439 DNA dealkylation (GO:0035510) 1/18 0.1655504 1.0000000 0 0 5.5555556 9.9915545 APOBEC2
440 negative regulation of transforming growth factor beta receptor signaling pathway (GO:0030512) 2/73 0.1656331 1.0000000 0 0 2.7397260 4.9259739 PEG10;FBN1
441 regulation of BMP signaling pathway (GO:0030510) 2/73 0.1656331 1.0000000 0 0 2.7397260 4.9259739 GPC3;FBN1
442 negative regulation of T cell activation (GO:0050868) 2/73 0.1656331 1.0000000 0 0 2.7397260 4.9259739 SFTPD;SCGB1A1
443 divalent inorganic cation homeostasis (GO:0072507) 5/291 0.1676310 1.0000000 0 0 1.7182131 3.0687119 KISS1;CD52;GJA1;CCL5;KCNK3
444 regulation of system process (GO:0044057) 6/371 0.1686521 1.0000000 0 0 1.6172507 2.8785729 KISS1;NPPC;GJA1;OR51E2;ALOX12;HOPX
445 negative regulation of response to external stimulus (GO:0032102) 4/215 0.1691759 1.0000000 0 0 1.8604651 3.3057044 ROBO2;PROS1;ALOX12;IFIT1
446 regulation of organ growth (GO:0046620) 2/74 0.1691769 1.0000000 0 0 2.7027027 4.8021906 GJA1;FGF9
447 blood vessel morphogenesis (GO:0048514) 2/74 0.1691769 1.0000000 0 0 2.7027027 4.8021906 GJA1;FLT4
448 regulation of peptidase activity (GO:0052547) 6/372 0.1700947 1.0000000 0 0 1.6129032 2.8570965 PCOLCE2;DLC1;PROS1;GPC3;ALOX12;A2ML1
449 response to toxic substance (GO:0009636) 3/142 0.1701252 1.0000000 0 0 2.1126761 3.7420149 DDC;CCL5;CYP2F1
450 neutrophil activation (GO:0042119) 1/19 0.1739024 1.0000000 0 0 5.2631579 9.2066381 CCL5
451 nucleotide transport (GO:0006862) 1/19 0.1739024 1.0000000 0 0 5.2631579 9.2066381 GJA1
452 reflex (GO:0060004) 1/19 0.1739024 1.0000000 0 0 5.2631579 9.2066381 GJA1
453 regulation of water loss via skin (GO:0033561) 1/19 0.1739024 1.0000000 0 0 5.2631579 9.2066381 ALOX12
454 regulation of cGMP biosynthetic process (GO:0030826) 1/19 0.1739024 1.0000000 0 0 5.2631579 9.2066381 NPPC
455 regulation of execution phase of apoptosis (GO:1900117) 1/19 0.1739024 1.0000000 0 0 5.2631579 9.2066381 DLC1
456 innate immune response in mucosa (GO:0002227) 1/19 0.1739024 1.0000000 0 0 5.2631579 9.2066381 PLA2G1B
457 regulation of interleukin-2 biosynthetic process (GO:0045076) 1/19 0.1739024 1.0000000 0 0 5.2631579 9.2066381 SFTPD
458 retinal ganglion cell axon guidance (GO:0031290) 1/19 0.1739024 1.0000000 0 0 5.2631579 9.2066381 ROBO2
459 cell-cell junction assembly (GO:0007043) 2/77 0.1798830 1.0000000 0 0 2.5974026 4.4557106 GJA1;RAMP2
460 regulation of defense response to virus (GO:0050688) 2/77 0.1798830 1.0000000 0 0 2.5974026 4.4557106 CD8B;IFIT1
461 multi-organism behavior (GO:0051705) 2/77 0.1798830 1.0000000 0 0 2.5974026 4.4557106 GRID1;SNCG
462 modulation by host of viral transcription (GO:0043921) 1/20 0.1821712 1.0000000 0 0 5.0000000 8.5140422 CCL5
463 modulation by host of symbiont transcription (GO:0052472) 1/20 0.1821712 1.0000000 0 0 5.0000000 8.5140422 CCL5
464 T cell mediated immunity (GO:0002456) 1/20 0.1821712 1.0000000 0 0 5.0000000 8.5140422 CRTAM
465 cellular biogenic amine biosynthetic process (GO:0042401) 1/20 0.1821712 1.0000000 0 0 5.0000000 8.5140422 DDC
466 positive regulation of cGMP metabolic process (GO:0030825) 1/20 0.1821712 1.0000000 0 0 5.0000000 8.5140422 NPPC
467 regulation of membrane repolarization (GO:0060306) 1/20 0.1821712 1.0000000 0 0 5.0000000 8.5140422 GJA1
468 negative regulation of endothelial cell apoptotic process (GO:2000352) 1/20 0.1821712 1.0000000 0 0 5.0000000 8.5140422 RAMP2
469 renal system process involved in regulation of systemic arterial blood pressure (GO:0003071) 1/20 0.1821712 1.0000000 0 0 5.0000000 8.5140422 GJA1
470 positive regulation of cardiac muscle cell proliferation (GO:0060045) 1/20 0.1821712 1.0000000 0 0 5.0000000 8.5140422 FGF9
471 nicotinamide nucleotide biosynthetic process (GO:0019359) 1/20 0.1821712 1.0000000 0 0 5.0000000 8.5140422 QPRT
472 neuromuscular synaptic transmission (GO:0007274) 1/20 0.1821712 1.0000000 0 0 5.0000000 8.5140422 SLC5A7
473 epithelial tube branching involved in lung morphogenesis (GO:0060441) 1/20 0.1821712 1.0000000 0 0 5.0000000 8.5140422 HHIP
474 sialylation (GO:0097503) 1/20 0.1821712 1.0000000 0 0 5.0000000 8.5140422 ST6GAL2
475 pyridine nucleotide biosynthetic process (GO:0019363) 1/20 0.1821712 1.0000000 0 0 5.0000000 8.5140422 QPRT
476 positive regulation of T cell migration (GO:2000406) 1/20 0.1821712 1.0000000 0 0 5.0000000 8.5140422 CCL5
477 regulation of amino acid transport (GO:0051955) 1/20 0.1821712 1.0000000 0 0 5.0000000 8.5140422 GRIK1
478 positive regulation of leukocyte mediated immunity (GO:0002705) 2/78 0.1834746 1.0000000 0 0 2.5641026 4.3478946 KLRK1;CRTAM
479 ovulation cycle process (GO:0022602) 2/78 0.1834746 1.0000000 0 0 2.5641026 4.3478946 ROBO2;KISS1
480 cation homeostasis (GO:0055080) 7/465 0.1855520 1.0000000 0 0 1.5053763 2.5356861 KISS1;CD52;GJA1;CCL5;SLC4A10;KCNK3;ABCG2
481 regulation of blood coagulation (GO:0030193) 2/79 0.1870767 1.0000000 0 0 2.5316456 4.2436366 PROS1;ALOX12
482 regulation of hemostasis (GO:1900046) 2/79 0.1870767 1.0000000 0 0 2.5316456 4.2436366 PROS1;ALOX12
483 response to peptide (GO:1901652) 6/384 0.1878023 1.0000000 0 0 1.5625000 2.6130713 MC4R;GJA1;FABP3;FGF9;PLA2G1B;FGF18
484 modulation of transcription in other organism involved in symbiotic interaction (GO:0052312) 1/21 0.1903576 1.0000000 0 0 4.7619048 7.8992886 CCL5
485 amine biosynthetic process (GO:0009309) 1/21 0.1903576 1.0000000 0 0 4.7619048 7.8992886 DDC
486 bile acid biosynthetic process (GO:0006699) 1/21 0.1903576 1.0000000 0 0 4.7619048 7.8992886 CH25H
487 dendritic cell migration (GO:0036336) 1/21 0.1903576 1.0000000 0 0 4.7619048 7.8992886 CCL5
488 granulocyte activation (GO:0036230) 1/21 0.1903576 1.0000000 0 0 4.7619048 7.8992886 CCL5
489 regulation of T-helper 1 type immune response (GO:0002825) 1/21 0.1903576 1.0000000 0 0 4.7619048 7.8992886 HLA-DQB2
490 regulation of interleukin-4 production (GO:0032673) 1/21 0.1903576 1.0000000 0 0 4.7619048 7.8992886 SCGB1A1
491 positive regulation of phospholipase activity (GO:0010518) 2/80 0.1906887 1.0000000 0 0 2.5000000 4.1427819 PLA2G1B;CCL5
492 negative regulation of DNA metabolic process (GO:0051053) 2/80 0.1906887 1.0000000 0 0 2.5000000 4.1427819 NPPC;APOBEC3H
493 retinoid metabolic process (GO:0001523) 2/81 0.1943101 1.0000000 0 0 2.4691358 4.0451846 OPN1SW;GPC3
494 pyrimidine-containing compound metabolic process (GO:0072527) 2/81 0.1943101 1.0000000 0 0 2.4691358 4.0451846 APOBEC2;APOBEC3H
495 positive regulation of viral process (GO:0048524) 2/81 0.1943101 1.0000000 0 0 2.4691358 4.0451846 CCL5;IFIT1
496 regulation of canonical Wnt signaling pathway (GO:0060828) 3/152 0.1950998 1.0000000 0 0 1.9736842 3.2254818 FGF9;GPC3;LGR5
497 positive regulation of cytosolic calcium ion concentration (GO:0007204) 3/152 0.1950998 1.0000000 0 0 1.9736842 3.2254818 KISS1;CD52;GJA1
498 receptor-mediated endocytosis (GO:0006898) 3/152 0.1950998 1.0000000 0 0 1.9736842 3.2254818 RAMP2;SFTPD;LRP1B
499 cellular cation homeostasis (GO:0030003) 6/389 0.1953866 1.0000000 0 0 1.5424165 2.5184188 KISS1;CD52;GJA1;CCL5;KCNK3;ABCG2
500 male meiosis (GO:0007140) 1/22 0.1984626 1.0000000 0 0 4.5454545 7.3507034 MEIOB
501 regulation of cGMP metabolic process (GO:0030823) 1/22 0.1984626 1.0000000 0 0 4.5454545 7.3507034 NPPC
502 positive regulation of cardiac muscle tissue growth (GO:0055023) 1/22 0.1984626 1.0000000 0 0 4.5454545 7.3507034 FGF9
503 central nervous system projection neuron axonogenesis (GO:0021952) 1/22 0.1984626 1.0000000 0 0 4.5454545 7.3507034 DCX
504 meiosis I (GO:0007127) 1/22 0.1984626 1.0000000 0 0 4.5454545 7.3507034 MEIOB
505 myofibril assembly (GO:0030239) 1/22 0.1984626 1.0000000 0 0 4.5454545 7.3507034 MYOZ1
506 apoptotic process involved in development (GO:1902742) 1/22 0.1984626 1.0000000 0 0 4.5454545 7.3507034 ROBO2
507 organic hydroxy compound metabolic process (GO:1901615) 7/476 0.2006601 1.0000000 0 0 1.4705882 2.3619745 CH25H;DDC;ADH1C;ADH1B;PLA2G1B;LEPR;ALOX12
508 cellular response to abiotic stimulus (GO:0071214) 4/232 0.2031974 1.0000000 0 0 1.7241379 2.7475468 MFAP4;GJA1;CNGA1;SNCG
509 positive regulation of MAPK cascade (GO:0043410) 6/395 0.2046385 1.0000000 0 0 1.5189873 2.4098887 KISS1;FGF9;PLA2G1B;FLT4;DIRAS2;FGF18
510 reactive oxygen species metabolic process (GO:0072593) 2/84 0.2052251 1.0000000 0 0 2.3809524 3.7705904 SFTPD;ALOX12
511 chloride transmembrane transport (GO:1902476) 2/84 0.2052251 1.0000000 0 0 2.3809524 3.7705904 GABRD;CLCA4
512 DNA catabolic process, exonucleolytic (GO:0000738) 1/23 0.2064868 1.0000000 0 0 4.3478261 6.8587782 MEIOB
513 endothelial cell differentiation (GO:0045446) 1/23 0.2064868 1.0000000 0 0 4.3478261 6.8587782 SCUBE1
514 cell-substrate adherens junction assembly (GO:0007045) 1/23 0.2064868 1.0000000 0 0 4.3478261 6.8587782 DLC1
515 focal adhesion assembly (GO:0048041) 1/23 0.2064868 1.0000000 0 0 4.3478261 6.8587782 DLC1
516 regulation of macrophage activation (GO:0043030) 1/23 0.2064868 1.0000000 0 0 4.3478261 6.8587782 BPI
517 detection of biotic stimulus (GO:0009595) 1/23 0.2064868 1.0000000 0 0 4.3478261 6.8587782 CRTAM
518 phosphatidylethanolamine acyl-chain remodeling (GO:0036152) 1/23 0.2064868 1.0000000 0 0 4.3478261 6.8587782 PLA2G1B
519 regulation of activin receptor signaling pathway (GO:0032925) 1/23 0.2064868 1.0000000 0 0 4.3478261 6.8587782 DMRT1
520 positive regulation vascular endothelial growth factor production (GO:0010575) 1/23 0.2064868 1.0000000 0 0 4.3478261 6.8587782 FLT4
521 drug transport (GO:0015893) 1/23 0.2064868 1.0000000 0 0 4.3478261 6.8587782 ABCG2
522 positive regulation of organic acid transport (GO:0032892) 1/23 0.2064868 1.0000000 0 0 4.3478261 6.8587782 GRIK1
523 negative regulation of organ growth (GO:0046621) 1/23 0.2064868 1.0000000 0 0 4.3478261 6.8587782 GJA1
524 regulation of T cell migration (GO:2000404) 1/23 0.2064868 1.0000000 0 0 4.3478261 6.8587782 CCL5
525 positive regulation of amine transport (GO:0051954) 1/23 0.2064868 1.0000000 0 0 4.3478261 6.8587782 GRIK1
526 regulation of coagulation (GO:0050818) 2/85 0.2088786 1.0000000 0 0 2.3529412 3.6847110 PROS1;ALOX12
527 female pregnancy (GO:0007565) 2/85 0.2088786 1.0000000 0 0 2.3529412 3.6847110 RAMP2;SCGB1A1
528 positive regulation of synaptic transmission (GO:0050806) 2/85 0.2088786 1.0000000 0 0 2.3529412 3.6847110 KISS1;GRIK1
529 cellular response to light stimulus (GO:0071482) 2/85 0.2088786 1.0000000 0 0 2.3529412 3.6847110 MFAP4;CNGA1
530 single organismal cell-cell adhesion (GO:0016337) 4/235 0.2094034 1.0000000 0 0 1.7021277 2.6612640 CCL5;ANXA9;JAM2;CDH7
531 regulation of reproductive process (GO:2000241) 2/86 0.2125388 1.0000000 0 0 2.3255814 3.6014667 NPPC;DMRT1
532 myeloid leukocyte activation (GO:0002274) 2/86 0.2125388 1.0000000 0 0 2.3255814 3.6014667 CX3CR1;CCL5
533 vascular process in circulatory system (GO:0003018) 2/86 0.2125388 1.0000000 0 0 2.3255814 3.6014667 NPPC;RAMP2
534 positive regulation of filopodium assembly (GO:0051491) 1/24 0.2144310 1.0000000 0 0 4.1666667 6.4156966 GPM6A
535 mucosal immune response (GO:0002385) 1/24 0.2144310 1.0000000 0 0 4.1666667 6.4156966 PLA2G1B
536 vascular endothelial growth factor receptor signaling pathway (GO:0048010) 1/24 0.2144310 1.0000000 0 0 4.1666667 6.4156966 FLT4
537 positive regulation of leukocyte apoptotic process (GO:2000108) 1/24 0.2144310 1.0000000 0 0 4.1666667 6.4156966 CCL5
538 gamma-aminobutyric acid signaling pathway (GO:0007214) 1/24 0.2144310 1.0000000 0 0 4.1666667 6.4156966 GABBR2
539 negative regulation of adenylate cyclase activity (GO:0007194) 1/24 0.2144310 1.0000000 0 0 4.1666667 6.4156966 GABBR2
540 regulation of fatty acid oxidation (GO:0046320) 1/24 0.2144310 1.0000000 0 0 4.1666667 6.4156966 FABP3
541 negative regulation of muscle cell apoptotic process (GO:0010656) 1/24 0.2144310 1.0000000 0 0 4.1666667 6.4156966 ALOX12
542 leukotriene biosynthetic process (GO:0019370) 1/24 0.2144310 1.0000000 0 0 4.1666667 6.4156966 PLA2G1B
543 cofactor transport (GO:0051181) 1/24 0.2144310 1.0000000 0 0 4.1666667 6.4156966 ABCG2
544 cGMP metabolic process (GO:0046068) 1/24 0.2144310 1.0000000 0 0 4.1666667 6.4156966 NPPC
545 pyridine-containing compound biosynthetic process (GO:0072525) 1/24 0.2144310 1.0000000 0 0 4.1666667 6.4156966 QPRT
546 negative regulation of viral transcription (GO:0032897) 1/24 0.2144310 1.0000000 0 0 4.1666667 6.4156966 CCL5
547 positive regulation of response to biotic stimulus (GO:0002833) 1/24 0.2144310 1.0000000 0 0 4.1666667 6.4156966 CRTAM
548 positive regulation of lymphocyte migration (GO:2000403) 1/24 0.2144310 1.0000000 0 0 4.1666667 6.4156966 CCL5
549 cellular ion homeostasis (GO:0006873) 6/402 0.2156295 1.0000000 0 0 1.4925373 2.2898409 KISS1;CD52;GJA1;CCL5;KCNK3;ABCG2
550 regulation of ion homeostasis (GO:2000021) 3/160 0.2156879 1.0000000 0 0 1.8750000 2.8761054 GJA1;PLA2G1B;ALOX12
551 diterpenoid metabolic process (GO:0016101) 2/87 0.2162053 1.0000000 0 0 2.2988506 3.5207517 OPN1SW;GPC3
552 regulation of protein secretion (GO:0050708) 3/161 0.2182939 1.0000000 0 0 1.8633540 2.8358630 PLA2G1B;CRTAM;OR51E2
553 regulation of ERK1 and ERK2 cascade (GO:0070372) 3/161 0.2182939 1.0000000 0 0 1.8633540 2.8358630 FLT4;FGF18;DUSP26
554 fatty acid derivative metabolic process (GO:1901568) 2/88 0.2198775 1.0000000 0 0 2.2727273 3.4424652 PLA2G1B;ALOX12
555 icosanoid metabolic process (GO:0006690) 2/88 0.2198775 1.0000000 0 0 2.2727273 3.4424652 PLA2G1B;ALOX12
556 membrane hyperpolarization (GO:0060081) 1/25 0.2222961 1.0000000 0 0 4.0000000 6.0149794 GRIK1
557 peptidyl-glutamic acid modification (GO:0018200) 1/25 0.2222961 1.0000000 0 0 4.0000000 6.0149794 PROS1
558 regulation of T cell receptor signaling pathway (GO:0050856) 1/25 0.2222961 1.0000000 0 0 4.0000000 6.0149794 UBASH3A
559 regulation of potassium ion transmembrane transporter activity (GO:1901016) 1/25 0.2222961 1.0000000 0 0 4.0000000 6.0149794 KCNJ1
560 negative regulation of cyclase activity (GO:0031280) 1/25 0.2222961 1.0000000 0 0 4.0000000 6.0149794 GABBR2
561 osteoclast differentiation (GO:0030316) 1/25 0.2222961 1.0000000 0 0 4.0000000 6.0149794 GPC3
562 positive regulation of heart growth (GO:0060421) 1/25 0.2222961 1.0000000 0 0 4.0000000 6.0149794 FGF9
563 response to iron ion (GO:0010039) 1/25 0.2222961 1.0000000 0 0 4.0000000 6.0149794 ABCG2
564 positive regulation of cartilage development (GO:0061036) 1/25 0.2222961 1.0000000 0 0 4.0000000 6.0149794 FGF18
565 regulation of autophagy (GO:0010506) 2/89 0.2235550 1.0000000 0 0 2.2471910 3.3665119 SOGA3;KIAA0408
566 regulation of phospholipase activity (GO:0010517) 2/89 0.2235550 1.0000000 0 0 2.2471910 3.3665119 PLA2G1B;CCL5
567 protein tetramerization (GO:0051262) 2/89 0.2235550 1.0000000 0 0 2.2471910 3.3665119 CCL5;TGM3
568 positive regulation of lymphocyte activation (GO:0051251) 4/243 0.2262091 1.0000000 0 0 1.6460905 2.4465772 KLRK1;CCL5;TRAC;HLA-DQB2
569 epithelial tube morphogenesis (GO:0060562) 2/90 0.2272373 1.0000000 0 0 2.2222222 3.2928009 GJA1;GPC3
570 positive regulation of lipase activity (GO:0060193) 2/90 0.2272373 1.0000000 0 0 2.2222222 3.2928009 PLA2G1B;CCL5
571 regulation of neurotransmitter levels (GO:0001505) 2/90 0.2272373 1.0000000 0 0 2.2222222 3.2928009 SLC5A7;SLC6A13
572 positive regulation of endocytosis (GO:0045807) 2/90 0.2272373 1.0000000 0 0 2.2222222 3.2928009 SFTPD;GPC3
573 macrophage activation (GO:0042116) 1/26 0.2300829 1.0000000 0 0 3.8461538 5.6512139 CX3CR1
574 indole-containing compound metabolic process (GO:0042430) 1/26 0.2300829 1.0000000 0 0 3.8461538 5.6512139 DDC
575 positive regulation of vasoconstriction (GO:0045907) 1/26 0.2300829 1.0000000 0 0 3.8461538 5.6512139 GJA1
576 leukocyte mediated cytotoxicity (GO:0001909) 1/26 0.2300829 1.0000000 0 0 3.8461538 5.6512139 CRTAM
577 regulation of defense response to virus by host (GO:0050691) 1/26 0.2300829 1.0000000 0 0 3.8461538 5.6512139 IFIT1
578 phosphatidylcholine acyl-chain remodeling (GO:0036151) 1/26 0.2300829 1.0000000 0 0 3.8461538 5.6512139 PLA2G1B
579 positive regulation of tissue remodeling (GO:0034105) 1/26 0.2300829 1.0000000 0 0 3.8461538 5.6512139 MC4R
580 negative regulation of lyase activity (GO:0051350) 1/26 0.2300829 1.0000000 0 0 3.8461538 5.6512139 GABBR2
581 negative regulation of response to biotic stimulus (GO:0002832) 1/26 0.2300829 1.0000000 0 0 3.8461538 5.6512139 IFIT1
582 organ or tissue specific immune response (GO:0002251) 1/26 0.2300829 1.0000000 0 0 3.8461538 5.6512139 PLA2G1B
583 antibacterial humoral response (GO:0019731) 1/26 0.2300829 1.0000000 0 0 3.8461538 5.6512139 PLA2G1B
584 positive regulation of calcium ion transport (GO:0051928) 2/91 0.2309240 1.0000000 0 0 2.1978022 3.2212458 PLA2G1B;CCL5
585 organic hydroxy compound biosynthetic process (GO:1901617) 3/166 0.2314186 1.0000000 0 0 1.8072289 2.6449282 CH25H;DDC;ALOX12
586 growth (GO:0040007) 5/329 0.2338375 1.0000000 0 0 1.5197568 2.2084028 GJA1;NDRG4;ST6GAL2;DCX;EMP1
587 monocarboxylic acid biosynthetic process (GO:0072330) 3/167 0.2340613 1.0000000 0 0 1.7964072 2.6086929 CH25H;PLA2G1B;ALOX12
588 positive regulation of secretion by cell (GO:1903532) 4/247 0.2347399 1.0000000 0 0 1.6194332 2.3470074 KISS1;PLA2G1B;CRTAM;OR51E2
589 secretion by cell (GO:0032940) 6/415 0.2365598 1.0000000 0 0 1.4457831 2.0841749 MC4R;SLC5A7;PROS1;CCL5;SLC6A13;SNCG
590 phosphatidylserine metabolic process (GO:0006658) 1/27 0.2377921 1.0000000 0 0 3.7037037 5.3198467 PLA2G1B
591 regulation of vascular permeability (GO:0043114) 1/27 0.2377921 1.0000000 0 0 3.7037037 5.3198467 RAMP2
592 negative regulation of chemotaxis (GO:0050922) 1/27 0.2377921 1.0000000 0 0 3.7037037 5.3198467 ROBO2
593 regulation of complement activation (GO:0030449) 1/27 0.2377921 1.0000000 0 0 3.7037037 5.3198467 PROS1
594 negative regulation of interferon-gamma production (GO:0032689) 1/27 0.2377921 1.0000000 0 0 3.7037037 5.3198467 SCGB1A1
595 regulation of vascular endothelial growth factor production (GO:0010574) 1/27 0.2377921 1.0000000 0 0 3.7037037 5.3198467 FLT4
596 negative regulation of lymphocyte apoptotic process (GO:0070229) 1/27 0.2377921 1.0000000 0 0 3.7037037 5.3198467 CCL5
597 regulation of platelet activation (GO:0010543) 1/27 0.2377921 1.0000000 0 0 3.7037037 5.3198467 ALOX12
598 cellular response to fatty acid (GO:0071398) 1/27 0.2377921 1.0000000 0 0 3.7037037 5.3198467 OR51E2
599 neurotransmitter metabolic process (GO:0042133) 1/27 0.2377921 1.0000000 0 0 3.7037037 5.3198467 SLC5A7
600 positive regulation of cell-substrate adhesion (GO:0010811) 2/93 0.2383085 1.0000000 0 0 2.1505376 3.0842782 SMOC2;ECM2
601 antigen processing and presentation of exogenous peptide antigen via MHC class II (GO:0019886) 2/93 0.2383085 1.0000000 0 0 2.1505376 3.0842782 HLA-DOA;HLA-DQB2
602 regulation of metal ion transport (GO:0010959) 4/250 0.2411890 1.0000000 0 0 1.6000000 2.2754791 GJA1;PLA2G1B;CCL5;KCNJ1
603 regulation of cell-cell adhesion (GO:0022407) 2/94 0.2420055 1.0000000 0 0 2.1276596 3.0187127 CCL5;ALOX12
604 antigen processing and presentation of peptide antigen via MHC class II (GO:0002495) 2/94 0.2420055 1.0000000 0 0 2.1276596 3.0187127 HLA-DOA;HLA-DQB2
605 regulation of lymphocyte proliferation (GO:0050670) 3/170 0.2420212 1.0000000 0 0 1.7647059 2.5036409 CCL5;SFTPD;SCGB1A1
606 regulation of calcium ion transport (GO:0051924) 3/171 0.2446846 1.0000000 0 0 1.7543860 2.4697984 GJA1;PLA2G1B;CCL5
607 antigen processing and presentation of exogenous peptide antigen (GO:0002478) 3/171 0.2446846 1.0000000 0 0 1.7543860 2.4697984 CD207;HLA-DOA;HLA-DQB2
608 regulation of mononuclear cell proliferation (GO:0032944) 3/171 0.2446846 1.0000000 0 0 1.7543860 2.4697984 CCL5;SFTPD;SCGB1A1
609 negative regulation of cytokine biosynthetic process (GO:0042036) 1/28 0.2454244 1.0000000 0 0 3.5714286 5.0170219 SFTPD
610 response to fluid shear stress (GO:0034405) 1/28 0.2454244 1.0000000 0 0 3.5714286 5.0170219 GJA1
611 positive regulation of BMP signaling pathway (GO:0030513) 1/28 0.2454244 1.0000000 0 0 3.5714286 5.0170219 GPC3
612 dopamine metabolic process (GO:0042417) 1/28 0.2454244 1.0000000 0 0 3.5714286 5.0170219 DDC
613 tissue regeneration (GO:0042246) 1/28 0.2454244 1.0000000 0 0 3.5714286 5.0170219 GJA1
614 antimicrobial humoral response (GO:0019730) 1/28 0.2454244 1.0000000 0 0 3.5714286 5.0170219 PLA2G1B
615 rhythmic process (GO:0048511) 4/252 0.2455112 1.0000000 0 0 1.5873016 2.2292267 ROBO2;KISS1;DDC;HLF
616 regulation of lymphocyte mediated immunity (GO:0002706) 2/95 0.2457050 1.0000000 0 0 2.1052632 2.9549968 KLRK1;CRTAM
617 metal ion homeostasis (GO:0055065) 6/422 0.2480835 1.0000000 0 0 1.4218009 1.9819764 KISS1;CD52;GJA1;CCL5;KCNK3;ABCG2
618 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II (GO:0002504) 2/96 0.2494068 1.0000000 0 0 2.0833333 2.8930625 HLA-DOA;HLA-DQB2
619 antigen processing and presentation of exogenous antigen (GO:0019884) 3/173 0.2500255 1.0000000 0 0 1.7341040 2.4038017 CD207;HLA-DOA;HLA-DQB2
620 cellular response to heat (GO:0034605) 1/29 0.2529808 1.0000000 0 0 3.4482759 4.7394545 STAC
621 central nervous system neuron axonogenesis (GO:0021955) 1/29 0.2529808 1.0000000 0 0 3.4482759 4.7394545 DCX
622 response to pH (GO:0009268) 1/29 0.2529808 1.0000000 0 0 3.4482759 4.7394545 GJA1
623 lipopolysaccharide-mediated signaling pathway (GO:0031663) 1/29 0.2529808 1.0000000 0 0 3.4482759 4.7394545 CCL5
624 regulation of defense response to virus by virus (GO:0050690) 1/29 0.2529808 1.0000000 0 0 3.4482759 4.7394545 CD8B
625 positive regulation of cardiac muscle tissue development (GO:0055025) 1/29 0.2529808 1.0000000 0 0 3.4482759 4.7394545 FGF9
626 regulation of protein activation cascade (GO:2000257) 1/29 0.2529808 1.0000000 0 0 3.4482759 4.7394545 PROS1
627 cardiac muscle cell action potential involved in contraction (GO:0086002) 1/29 0.2529808 1.0000000 0 0 3.4482759 4.7394545 GJA1
628 regulation of fibroblast growth factor receptor signaling pathway (GO:0040036) 1/29 0.2529808 1.0000000 0 0 3.4482759 4.7394545 HHIP
629 cerebral cortex cell migration (GO:0021795) 1/29 0.2529808 1.0000000 0 0 3.4482759 4.7394545 CX3CR1
630 NAD metabolic process (GO:0019674) 1/29 0.2529808 1.0000000 0 0 3.4482759 4.7394545 QPRT
631 terpenoid metabolic process (GO:0006721) 2/97 0.2531103 1.0000000 0 0 2.0618557 2.8328453 OPN1SW;GPC3
632 alcohol metabolic process (GO:0006066) 5/340 0.2542695 1.0000000 0 0 1.4705882 2.0137658 CH25H;ADH1C;ADH1B;PLA2G1B;LEPR
633 detection of external stimulus (GO:0009581) 3/175 0.2553840 1.0000000 0 0 1.7142857 2.3399779 OPN1SW;CNGA1;GPC3
634 neuron projection morphogenesis (GO:0048812) 3/175 0.2553840 1.0000000 0 0 1.7142857 2.3399779 GPM6A;GJA1;DCX
635 osteoblast differentiation (GO:0001649) 2/98 0.2568151 1.0000000 0 0 2.0408163 2.7742832 GJA1;FGF9
636 regulation of leukocyte proliferation (GO:0070663) 3/176 0.2580694 1.0000000 0 0 1.7045455 2.3088527 CCL5;SFTPD;SCGB1A1
637 regulation of epithelial cell proliferation (GO:0050678) 4/258 0.2585787 1.0000000 0 0 1.5503876 2.0969850 KRT4;FGF9;FLT4;GPC3
638 lens development in camera-type eye (GO:0002088) 1/30 0.2604618 1.0000000 0 0 3.3333333 4.4843302 GJA1
639 hair follicle morphogenesis (GO:0031069) 1/30 0.2604618 1.0000000 0 0 3.3333333 4.4843302 TGM3
640 endochondral ossification (GO:0001958) 1/30 0.2604618 1.0000000 0 0 3.3333333 4.4843302 FGF18
641 positive regulation of multicellular organismal metabolic process (GO:0044253) 1/30 0.2604618 1.0000000 0 0 3.3333333 4.4843302 MC4R
642 embryonic hindlimb morphogenesis (GO:0035116) 1/30 0.2604618 1.0000000 0 0 3.3333333 4.4843302 GPC3
643 central nervous system neuron development (GO:0021954) 1/30 0.2604618 1.0000000 0 0 3.3333333 4.4843302 ROBO2
644 cardiac muscle cell action potential (GO:0086001) 1/30 0.2604618 1.0000000 0 0 3.3333333 4.4843302 GJA1
645 positive regulation of glucose import (GO:0046326) 1/30 0.2604618 1.0000000 0 0 3.3333333 4.4843302 GPC3
646 regulation of rhodopsin mediated signaling pathway (GO:0022400) 1/30 0.2604618 1.0000000 0 0 3.3333333 4.4843302 CNGA1
647 axon extension (GO:0048675) 1/30 0.2604618 1.0000000 0 0 3.3333333 4.4843302 DCX
648 regulation of granulocyte chemotaxis (GO:0071622) 1/30 0.2604618 1.0000000 0 0 3.3333333 4.4843302 CCL5
649 replacement ossification (GO:0036075) 1/30 0.2604618 1.0000000 0 0 3.3333333 4.4843302 FGF18
650 neurotransmitter transport (GO:0006836) 2/99 0.2605209 1.0000000 0 0 2.0202020 2.7173172 SLC5A7;SLC6A13
651 single organism cell adhesion (GO:0098602) 4/259 0.2607703 1.0000000 0 0 1.5444015 2.0758538 CCL5;ANXA9;JAM2;CDH7
652 detection of abiotic stimulus (GO:0009582) 3/178 0.2634516 1.0000000 0 0 1.6853933 2.2481220 OPN1SW;CNGA1;GPC3
653 cell-matrix adhesion (GO:0007160) 2/100 0.2642273 1.0000000 0 0 2.0000000 2.6618910 ECM2;PPFIA2
654 unsaturated fatty acid metabolic process (GO:0033559) 2/100 0.2642273 1.0000000 0 0 2.0000000 2.6618910 PLA2G1B;ALOX12
655 defense response to bacterium (GO:0042742) 3/179 0.2661481 1.0000000 0 0 1.6759777 2.2184959 PLA2G1B;SFTPD;BPI
656 positive regulation of leukocyte activation (GO:0002696) 4/262 0.2673668 1.0000000 0 0 1.5267176 2.0139444 KLRK1;CCL5;TRAC;HLA-DQB2
657 regulation of response to wounding (GO:1903034) 5/347 0.2674975 1.0000000 0 0 1.4409222 1.9000649 PROS1;CCL5;SCGB1A1;ALOX12;HOPX
658 bicarbonate transport (GO:0015701) 1/31 0.2678683 1.0000000 0 0 3.2258065 4.2492255 SLC4A10
659 phosphatidic acid biosynthetic process (GO:0006654) 1/31 0.2678683 1.0000000 0 0 3.2258065 4.2492255 PLA2G1B
660 positive regulation of blood pressure (GO:0045777) 1/31 0.2678683 1.0000000 0 0 3.2258065 4.2492255 OR51E2
661 cellular response to alkaloid (GO:0071312) 1/31 0.2678683 1.0000000 0 0 3.2258065 4.2492255 DDC
662 regulation of endothelial cell apoptotic process (GO:2000351) 1/31 0.2678683 1.0000000 0 0 3.2258065 4.2492255 RAMP2
663 regulation of meiosis (GO:0040020) 1/31 0.2678683 1.0000000 0 0 3.2258065 4.2492255 DMRT1
664 regulation of Rho protein signal transduction (GO:0035023) 1/31 0.2678683 1.0000000 0 0 3.2258065 4.2492255 DLC1
665 modification by host of symbiont morphology or physiology (GO:0051851) 1/31 0.2678683 1.0000000 0 0 3.2258065 4.2492255 CCL5
666 phenol-containing compound biosynthetic process (GO:0046189) 1/31 0.2678683 1.0000000 0 0 3.2258065 4.2492255 DDC
667 regulation of smooth muscle cell migration (GO:0014910) 1/31 0.2678683 1.0000000 0 0 3.2258065 4.2492255 CCL5
668 negative regulation of interleukin-6 production (GO:0032715) 1/31 0.2678683 1.0000000 0 0 3.2258065 4.2492255 BPI
669 protein kinase B signaling (GO:0043491) 1/31 0.2678683 1.0000000 0 0 3.2258065 4.2492255 CCL5
670 phosphatidic acid metabolic process (GO:0046473) 1/31 0.2678683 1.0000000 0 0 3.2258065 4.2492255 PLA2G1B
671 regulation of collagen metabolic process (GO:0010712) 1/31 0.2678683 1.0000000 0 0 3.2258065 4.2492255 MFAP4
672 peptide cross-linking (GO:0018149) 1/31 0.2678683 1.0000000 0 0 3.2258065 4.2492255 TGM3
673 positive chemotaxis (GO:0050918) 1/31 0.2678683 1.0000000 0 0 3.2258065 4.2492255 CCL5
674 tube morphogenesis (GO:0035239) 2/101 0.2679339 1.0000000 0 0 1.9801980 2.6079506 GJA1;GPC3
675 taxis (GO:0042330) 4/263 0.2695726 1.0000000 0 0 1.5209125 1.9937909 CX3CR1;PLA2G1B;CCL5;SFTPD
676 chemotaxis (GO:0006935) 4/263 0.2695726 1.0000000 0 0 1.5209125 1.9937909 CX3CR1;PLA2G1B;CCL5;SFTPD
677 negative regulation of lymphocyte activation (GO:0051250) 2/102 0.2716403 1.0000000 0 0 1.9607843 2.5554444 SFTPD;SCGB1A1
678 multi-organism localization (GO:1902579) 1/32 0.2752010 1.0000000 0 0 3.1250000 4.0320428 IFIT1
679 negative regulation of striated muscle tissue development (GO:0045843) 1/32 0.2752010 1.0000000 0 0 3.1250000 4.0320428 GJA1
680 positive regulation of protein tyrosine kinase activity (GO:0061098) 1/32 0.2752010 1.0000000 0 0 3.1250000 4.0320428 CCL5
681 intracellular transport of virus (GO:0075733) 1/32 0.2752010 1.0000000 0 0 3.1250000 4.0320428 IFIT1
682 multi-organism transport (GO:0044766) 1/32 0.2752010 1.0000000 0 0 3.1250000 4.0320428 IFIT1
683 multi-organism intracellular transport (GO:1902583) 1/32 0.2752010 1.0000000 0 0 3.1250000 4.0320428 IFIT1
684 regulation of potassium ion transmembrane transport (GO:1901379) 1/32 0.2752010 1.0000000 0 0 3.1250000 4.0320428 KCNJ1
685 multicellular organismal water homeostasis (GO:0050891) 1/32 0.2752010 1.0000000 0 0 3.1250000 4.0320428 ALOX12
686 negative regulation of cytokine-mediated signaling pathway (GO:0001960) 1/32 0.2752010 1.0000000 0 0 3.1250000 4.0320428 CCL5
687 transport of virus (GO:0046794) 1/32 0.2752010 1.0000000 0 0 3.1250000 4.0320428 IFIT1
688 negative regulation of cAMP biosynthetic process (GO:0030818) 1/32 0.2752010 1.0000000 0 0 3.1250000 4.0320428 GABBR2
689 superoxide metabolic process (GO:0006801) 1/32 0.2752010 1.0000000 0 0 3.1250000 4.0320428 ALOX12
690 response to pain (GO:0048265) 1/32 0.2752010 1.0000000 0 0 3.1250000 4.0320428 GRIK1
691 regulation of synaptic transmission, GABAergic (GO:0032228) 1/32 0.2752010 1.0000000 0 0 3.1250000 4.0320428 GRIK1
692 regulation of lymphocyte migration (GO:2000401) 1/32 0.2752010 1.0000000 0 0 3.1250000 4.0320428 CCL5
693 regulation of T cell apoptotic process (GO:0070232) 1/32 0.2752010 1.0000000 0 0 3.1250000 4.0320428 CCL5
694 regulation of transforming growth factor beta receptor signaling pathway (GO:0017015) 2/103 0.2753461 1.0000000 0 0 1.9417476 2.5043233 PEG10;FBN1
695 cellular response to fibroblast growth factor stimulus (GO:0044344) 3/183 0.2769660 1.0000000 0 0 1.6393443 2.1046893 FGF9;CCL5;FGF18
696 antigen processing and presentation of peptide antigen (GO:0048002) 3/185 0.2823919 1.0000000 0 0 1.6216216 2.0504748 CD207;HLA-DOA;HLA-DQB2
697 negative regulation of cytokine production (GO:0001818) 3/185 0.2823919 1.0000000 0 0 1.6216216 2.0504748 SFTPD;SCGB1A1;BPI
698 peptide hormone processing (GO:0016486) 1/33 0.2824605 1.0000000 0 0 3.0303030 3.8309588 SCG5
699 positive regulation of reproductive process (GO:2000243) 1/33 0.2824605 1.0000000 0 0 3.0303030 3.8309588 DMRT1
700 histone deacetylation (GO:0016575) 1/33 0.2824605 1.0000000 0 0 3.0303030 3.8309588 HOPX
701 interaction with symbiont (GO:0051702) 1/33 0.2824605 1.0000000 0 0 3.0303030 3.8309588 CCL5
702 regulation of bone resorption (GO:0045124) 1/33 0.2824605 1.0000000 0 0 3.0303030 3.8309588 MC4R
703 response to progesterone (GO:0032570) 1/33 0.2824605 1.0000000 0 0 3.0303030 3.8309588 RAMP2
704 rhodopsin mediated signaling pathway (GO:0016056) 1/33 0.2824605 1.0000000 0 0 3.0303030 3.8309588 CNGA1
705 negative regulation of cyclic nucleotide biosynthetic process (GO:0030803) 1/33 0.2824605 1.0000000 0 0 3.0303030 3.8309588 GABBR2
706 negative regulation of muscle tissue development (GO:1901862) 1/33 0.2824605 1.0000000 0 0 3.0303030 3.8309588 GJA1
707 positive regulation of ion transport (GO:0043270) 3/186 0.2851085 1.0000000 0 0 1.6129032 2.0240089 PLA2G1B;CCL5;GRIK1
708 immune response-regulating cell surface receptor signaling pathway (GO:0002768) 6/444 0.2852710 1.0000000 0 0 1.3513514 1.6950213 IGHG4;FGF9;TRAC;FGF18;SKAP1;HLA-DQB2
709 skeletal system morphogenesis (GO:0048705) 2/106 0.2864567 1.0000000 0 0 1.8867925 2.3588071 HHIP;TBX4
710 response to transition metal nanoparticle (GO:1990267) 2/106 0.2864567 1.0000000 0 0 1.8867925 2.3588071 KCNK3;ABCG2
711 brain development (GO:0007420) 3/187 0.2878273 1.0000000 0 0 1.6042781 1.9979593 ROBO2;DCX;KCNK3
712 organic acid biosynthetic process (GO:0016053) 4/272 0.2895615 1.0000000 0 0 1.4705882 1.8226289 CH25H;PLA2G1B;PADI3;ALOX12
713 carboxylic acid biosynthetic process (GO:0046394) 4/272 0.2895615 1.0000000 0 0 1.4705882 1.8226289 CH25H;PLA2G1B;PADI3;ALOX12
714 positive regulation of defense response (GO:0031349) 4/272 0.2895615 1.0000000 0 0 1.4705882 1.8226289 GJA1;KLRK1;CCL5;CRTAM
715 positive regulation of cell activation (GO:0050867) 4/272 0.2895615 1.0000000 0 0 1.4705882 1.8226289 KLRK1;CCL5;TRAC;HLA-DQB2
716 dendrite morphogenesis (GO:0048813) 1/34 0.2896478 1.0000000 0 0 2.9411765 3.6443812 DCX
717 negative regulation of muscle organ development (GO:0048635) 1/34 0.2896478 1.0000000 0 0 2.9411765 3.6443812 GJA1
718 negative regulation of reproductive process (GO:2000242) 1/34 0.2896478 1.0000000 0 0 2.9411765 3.6443812 NPPC
719 response to cocaine (GO:0042220) 1/34 0.2896478 1.0000000 0 0 2.9411765 3.6443812 SNCG
720 negative regulation of tumor necrosis factor production (GO:0032720) 1/34 0.2896478 1.0000000 0 0 2.9411765 3.6443812 BPI
721 phosphatidylglycerol metabolic process (GO:0046471) 1/34 0.2896478 1.0000000 0 0 2.9411765 3.6443812 PLA2G1B
722 negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway (GO:0090101) 2/107 0.2901569 1.0000000 0 0 1.8691589 2.3127732 PEG10;FBN1
723 cholesterol metabolic process (GO:0008203) 2/107 0.2901569 1.0000000 0 0 1.8691589 2.3127732 CH25H;LEPR
724 positive regulation of behavior (GO:0048520) 2/107 0.2901569 1.0000000 0 0 1.8691589 2.3127732 GJA1;CCL5
725 positive regulation of growth (GO:0045927) 3/189 0.2932710 1.0000000 0 0 1.5873016 1.9470766 FGF9;ALOX12;HOPX
726 inorganic anion transmembrane transport (GO:0098661) 2/108 0.2938547 1.0000000 0 0 1.8518519 2.2679071 GABRD;CLCA4
727 positive regulation of innate immune response (GO:0045089) 3/190 0.2959955 1.0000000 0 0 1.5789474 1.9222277 KLRK1;CCL5;CRTAM
728 dendrite development (GO:0016358) 1/35 0.2967634 1.0000000 0 0 2.8571429 3.4709146 FEZF2
729 positive regulation of glucose transport (GO:0010828) 1/35 0.2967634 1.0000000 0 0 2.8571429 3.4709146 GPC3
730 insulin secretion (GO:0030073) 1/35 0.2967634 1.0000000 0 0 2.8571429 3.4709146 MC4R
731 regulation of antigen receptor-mediated signaling pathway (GO:0050854) 1/35 0.2967634 1.0000000 0 0 2.8571429 3.4709146 UBASH3A
732 negative regulation of purine nucleotide biosynthetic process (GO:1900372) 1/35 0.2967634 1.0000000 0 0 2.8571429 3.4709146 GABBR2
733 myeloid cell activation involved in immune response (GO:0002275) 1/35 0.2967634 1.0000000 0 0 2.8571429 3.4709146 CX3CR1
734 alditol phosphate metabolic process (GO:0052646) 1/35 0.2967634 1.0000000 0 0 2.8571429 3.4709146 PLA2G1B
735 regulation of filopodium assembly (GO:0051489) 1/35 0.2967634 1.0000000 0 0 2.8571429 3.4709146 GPM6A
736 metanephros development (GO:0001656) 1/35 0.2967634 1.0000000 0 0 2.8571429 3.4709146 ROBO2
737 negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556) 1/35 0.2967634 1.0000000 0 0 2.8571429 3.4709146 BPI
738 embryonic skeletal system development (GO:0048706) 1/35 0.2967634 1.0000000 0 0 2.8571429 3.4709146 FGF9
739 neuron projection extension (GO:1990138) 1/35 0.2967634 1.0000000 0 0 2.8571429 3.4709146 DCX
740 positive regulation of phagocytosis (GO:0050766) 1/35 0.2967634 1.0000000 0 0 2.8571429 3.4709146 SFTPD
741 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001240) 1/35 0.2967634 1.0000000 0 0 2.8571429 3.4709146 CX3CR1
742 negative regulation of signal transduction in absence of ligand (GO:1901099) 1/35 0.2967634 1.0000000 0 0 2.8571429 3.4709146 CX3CR1
743 cAMP metabolic process (GO:0046058) 1/35 0.2967634 1.0000000 0 0 2.8571429 3.4709146 RAMP2
744 negative regulation of nucleotide biosynthetic process (GO:0030809) 1/35 0.2967634 1.0000000 0 0 2.8571429 3.4709146 GABBR2
745 negative regulation of ERK1 and ERK2 cascade (GO:0070373) 1/35 0.2967634 1.0000000 0 0 2.8571429 3.4709146 DUSP26
746 cellular chemical homeostasis (GO:0055082) 6/452 0.2990968 1.0000000 0 0 1.3274336 1.6021964 KISS1;CD52;GJA1;CCL5;KCNK3;ABCG2
747 negative regulation of epithelial cell proliferation (GO:0050680) 2/110 0.3012423 1.0000000 0 0 1.8181818 2.1815278 KRT4;GPC3
748 cellular response to lipopolysaccharide (GO:0071222) 2/110 0.3012423 1.0000000 0 0 1.8181818 2.1815278 CX3CR1;CCL5
749 regulation of gluconeogenesis (GO:0006111) 1/36 0.3038081 1.0000000 0 0 2.7777778 3.3093308 LEPR
750 regulation of cell adhesion mediated by integrin (GO:0033628) 1/36 0.3038081 1.0000000 0 0 2.7777778 3.3093308 CCL5
751 negative regulation of response to cytokine stimulus (GO:0060761) 1/36 0.3038081 1.0000000 0 0 2.7777778 3.3093308 CCL5
752 regulation of catecholamine secretion (GO:0050433) 1/36 0.3038081 1.0000000 0 0 2.7777778 3.3093308 SNCG
753 negative regulation of cellular carbohydrate metabolic process (GO:0010677) 1/36 0.3038081 1.0000000 0 0 2.7777778 3.3093308 LEPR
754 placenta development (GO:0001890) 1/36 0.3038081 1.0000000 0 0 2.7777778 3.3093308 PEG10
755 negative regulation of cAMP metabolic process (GO:0030815) 1/36 0.3038081 1.0000000 0 0 2.7777778 3.3093308 GABBR2
756 chromosome organization involved in meiosis (GO:0070192) 1/36 0.3038081 1.0000000 0 0 2.7777778 3.3093308 MEIOB
757 positive regulation of organ growth (GO:0046622) 1/36 0.3038081 1.0000000 0 0 2.7777778 3.3093308 FGF9
758 protein deacetylation (GO:0006476) 1/36 0.3038081 1.0000000 0 0 2.7777778 3.3093308 HOPX
759 response to alkaloid (GO:0043279) 2/111 0.3049314 1.0000000 0 0 1.8018018 2.1399429 DDC;SNCG
760 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process (GO:0043280) 2/111 0.3049314 1.0000000 0 0 1.8018018 2.1399429 DLC1;ALOX12
761 synapse organization (GO:0050808) 2/111 0.3049314 1.0000000 0 0 1.8018018 2.1399429 GPM6A;SNCG
762 positive regulation of cell migration (GO:0030335) 4/280 0.3074995 1.0000000 0 0 1.4285714 1.6846883 FLT4;CCL5;ALOX12;GPR124
763 regulation of striated muscle tissue development (GO:0016202) 2/112 0.3086171 1.0000000 0 0 1.7857143 2.0993823 GJA1;FGF9
764 cellular response to insulin stimulus (GO:0032869) 3/195 0.3096393 1.0000000 0 0 1.5384615 1.8036111 FGF9;PLA2G1B;FGF18
765 positive regulation of mesenchymal cell proliferation (GO:0002053) 1/37 0.3107825 1.0000000 0 0 2.7027027 3.1585455 FGF9
766 anterior/posterior axis specification (GO:0009948) 1/37 0.3107825 1.0000000 0 0 2.7027027 3.1585455 GPC3
767 positive regulation of calcium ion transport into cytosol (GO:0010524) 1/37 0.3107825 1.0000000 0 0 2.7027027 3.1585455 PLA2G1B
768 negative regulation of cyclic nucleotide metabolic process (GO:0030800) 1/37 0.3107825 1.0000000 0 0 2.7027027 3.1585455 GABBR2
769 regulation of muscle tissue development (GO:1901861) 2/113 0.3122988 1.0000000 0 0 1.7699115 2.0598136 GJA1;FGF9
770 regulation of muscle organ development (GO:0048634) 2/114 0.3159765 1.0000000 0 0 1.7543860 2.0212059 GJA1;FGF9
771 isoprenoid metabolic process (GO:0006720) 2/114 0.3159765 1.0000000 0 0 1.7543860 2.0212059 OPN1SW;GPC3
772 cellular response to hormone stimulus (GO:0032870) 6/462 0.3165564 1.0000000 0 0 1.2987013 1.4938364 ROBO2;RAMP2;FGF9;PLA2G1B;FGF18;OR51E2
773 negative regulation of Ras protein signal transduction (GO:0046580) 1/38 0.3176875 1.0000000 0 0 2.6315789 3.0175977 DLC1
774 anion homeostasis (GO:0055081) 1/38 0.3176875 1.0000000 0 0 2.6315789 3.0175977 FABP3
775 regulation of muscle cell apoptotic process (GO:0010660) 1/38 0.3176875 1.0000000 0 0 2.6315789 3.0175977 ALOX12
776 water homeostasis (GO:0030104) 1/38 0.3176875 1.0000000 0 0 2.6315789 3.0175977 ALOX12
777 hindlimb morphogenesis (GO:0035137) 1/38 0.3176875 1.0000000 0 0 2.6315789 3.0175977 GPC3
778 leukocyte activation (GO:0045321) 5/373 0.3177926 1.0000000 0 0 1.3404826 1.5366707 CX3CR1;KLRK1;CD8B;CCL5;CRTAM
779 negative regulation of cell adhesion (GO:0007162) 2/115 0.3196498 1.0000000 0 0 1.7391304 1.9835291 ALOX12;JAM2
780 positive regulation of ERK1 and ERK2 cascade (GO:0070374) 2/115 0.3196498 1.0000000 0 0 1.7391304 1.9835291 FLT4;FGF18
781 positive regulation of cell motility (GO:2000147) 4/287 0.3232894 1.0000000 0 0 1.3937282 1.5738081 FLT4;CCL5;ALOX12;GPR124
782 cellular response to molecule of bacterial origin (GO:0071219) 2/116 0.3233184 1.0000000 0 0 1.7241379 1.9467545 CX3CR1;CCL5
783 ossification (GO:0001503) 2/116 0.3233184 1.0000000 0 0 1.7241379 1.9467545 NPPC;FGF18
784 social behavior (GO:0035176) 1/39 0.3245236 1.0000000 0 0 2.5641026 2.8856335 GRID1
785 heart morphogenesis (GO:0003007) 1/39 0.3245236 1.0000000 0 0 2.5641026 2.8856335 DLC1
786 positive regulation of cell-cell adhesion (GO:0022409) 1/39 0.3245236 1.0000000 0 0 2.5641026 2.8856335 CCL5
787 bone mineralization (GO:0030282) 1/39 0.3245236 1.0000000 0 0 2.5641026 2.8856335 GPC3
788 bile acid metabolic process (GO:0008206) 1/39 0.3245236 1.0000000 0 0 2.5641026 2.8856335 CH25H
789 positive regulation of striated muscle cell differentiation (GO:0051155) 1/39 0.3245236 1.0000000 0 0 2.5641026 2.8856335 HOPX
790 intraspecies interaction between organisms (GO:0051703) 1/39 0.3245236 1.0000000 0 0 2.5641026 2.8856335 GRID1
791 embryo implantation (GO:0007566) 1/39 0.3245236 1.0000000 0 0 2.5641026 2.8856335 SCGB1A1
792 tight junction assembly (GO:0070830) 1/39 0.3245236 1.0000000 0 0 2.5641026 2.8856335 RAMP2
793 protein deacylation (GO:0035601) 1/39 0.3245236 1.0000000 0 0 2.5641026 2.8856335 HOPX
794 negative regulation of small GTPase mediated signal transduction (GO:0051058) 1/39 0.3245236 1.0000000 0 0 2.5641026 2.8856335 DLC1
795 sterol biosynthetic process (GO:0016126) 1/39 0.3245236 1.0000000 0 0 2.5641026 2.8856335 CH25H
796 response to bacterium (GO:0009617) 3/201 0.3260385 1.0000000 0 0 1.4925373 1.6727460 PLA2G1B;SFTPD;BPI
797 secondary metabolic process (GO:0019748) 1/40 0.3312915 1.0000000 0 0 2.5000000 2.7618913 DDC
798 negative regulation of BMP signaling pathway (GO:0030514) 1/40 0.3312915 1.0000000 0 0 2.5000000 2.7618913 FBN1
799 ureteric bud development (GO:0001657) 1/40 0.3312915 1.0000000 0 0 2.5000000 2.7618913 ROBO2
800 cellular response to cytokine stimulus (GO:0071345) 6/471 0.3324065 1.0000000 0 0 1.2738854 1.4030529 CX3CR1;CCL5;LEPR;IFIT1;HLA-DQB2;OASL
801 negative regulation of locomotion (GO:0040013) 3/204 0.3342400 1.0000000 0 0 1.4705882 1.6116117 ROBO2;CX3CR1;DLC1
802 sterol metabolic process (GO:0016125) 2/119 0.3342935 1.0000000 0 0 1.6806723 1.8415730 CH25H;LEPR
803 positive regulation of cysteine-type endopeptidase activity (GO:2001056) 2/119 0.3342935 1.0000000 0 0 1.6806723 1.8415730 DLC1;ALOX12
804 regulation of leukocyte mediated immunity (GO:0002703) 2/120 0.3379407 1.0000000 0 0 1.6666667 1.8081412 KLRK1;CRTAM
805 positive regulation of cell division (GO:0051781) 2/120 0.3379407 1.0000000 0 0 1.6666667 1.8081412 FGF9;DMRT1
806 macromolecule deacylation (GO:0098732) 1/41 0.3379920 1.0000000 0 0 2.4390244 2.6456903 HOPX
807 negative regulation of cell-cell adhesion (GO:0022408) 1/41 0.3379920 1.0000000 0 0 2.4390244 2.6456903 ALOX12
808 cell-substrate junction assembly (GO:0007044) 1/41 0.3379920 1.0000000 0 0 2.4390244 2.6456903 DLC1
809 response to exogenous dsRNA (GO:0043330) 1/41 0.3379920 1.0000000 0 0 2.4390244 2.6456903 IFIT1
810 T cell proliferation (GO:0042098) 1/41 0.3379920 1.0000000 0 0 2.4390244 2.6456903 CRTAM
811 negative regulation of leukocyte apoptotic process (GO:2000107) 1/41 0.3379920 1.0000000 0 0 2.4390244 2.6456903 CCL5
812 regulation of synapse assembly (GO:0051963) 1/41 0.3379920 1.0000000 0 0 2.4390244 2.6456903 ROBO2
813 oligosaccharide metabolic process (GO:0009311) 1/41 0.3379920 1.0000000 0 0 2.4390244 2.6456903 ST6GAL2
814 regulation of chondrocyte differentiation (GO:0032330) 1/41 0.3379920 1.0000000 0 0 2.4390244 2.6456903 FGF18
815 response to zinc ion (GO:0010043) 1/41 0.3379920 1.0000000 0 0 2.4390244 2.6456903 KCNK3
816 positive regulation of wound healing (GO:0090303) 1/41 0.3379920 1.0000000 0 0 2.4390244 2.6456903 HOPX
817 multi-multicellular organism process (GO:0044706) 2/121 0.3415820 1.0000000 0 0 1.6528926 1.7754835 RAMP2;SCGB1A1
818 morphogenesis of an epithelium (GO:0002009) 4/296 0.3436708 1.0000000 0 0 1.3513514 1.4433392 GJA1;HHIP;GPC3;TBX4
819 positive regulation of cellular component movement (GO:0051272) 4/296 0.3436708 1.0000000 0 0 1.3513514 1.4433392 FLT4;CCL5;ALOX12;GPR124
820 positive regulation of mitosis (GO:0045840) 1/42 0.3446257 1.0000000 0 0 2.3809524 2.5364201 DMRT1
821 nucleotide biosynthetic process (GO:0009165) 3/208 0.3451691 1.0000000 0 0 1.4423077 1.5342129 NPPC;RAMP2;QPRT
822 regulation of lipase activity (GO:0060191) 2/122 0.3452170 1.0000000 0 0 1.6393443 1.7435771 PLA2G1B;CCL5
823 nucleoside phosphate biosynthetic process (GO:1901293) 3/209 0.3478993 1.0000000 0 0 1.4354067 1.5155629 NPPC;RAMP2;QPRT
824 positive regulation of multi-organism process (GO:0043902) 2/123 0.3488456 1.0000000 0 0 1.6260163 1.7123999 CCL5;IFIT1
825 cell killing (GO:0001906) 1/43 0.3511932 1.0000000 0 0 2.3255814 2.4335320 CRTAM
826 catechol-containing compound metabolic process (GO:0009712) 1/43 0.3511932 1.0000000 0 0 2.3255814 2.4335320 DDC
827 regulation of mesenchymal cell proliferation (GO:0010464) 1/43 0.3511932 1.0000000 0 0 2.3255814 2.4335320 FGF9
828 receptor internalization (GO:0031623) 1/43 0.3511932 1.0000000 0 0 2.3255814 2.4335320 RAMP2
829 negative regulation of carbohydrate metabolic process (GO:0045912) 1/43 0.3511932 1.0000000 0 0 2.3255814 2.4335320 LEPR
830 catecholamine metabolic process (GO:0006584) 1/43 0.3511932 1.0000000 0 0 2.3255814 2.4335320 DDC
831 regulation of organic acid transport (GO:0032890) 1/43 0.3511932 1.0000000 0 0 2.3255814 2.4335320 GRIK1
832 carbohydrate derivative transport (GO:1901264) 1/43 0.3511932 1.0000000 0 0 2.3255814 2.4335320 GJA1
833 regulation of cytokine production (GO:0001817) 6/482 0.3519100 1.0000000 0 0 1.2448133 1.3000578 FLT4;SFTPD;CRTAM;SCGB1A1;BPI;UBASH3A
834 cellular biogenic amine metabolic process (GO:0006576) 2/125 0.3560824 1.0000000 0 0 1.6000000 1.6521490 DDC;PLA2G1B
835 cellular amine metabolic process (GO:0044106) 2/125 0.3560824 1.0000000 0 0 1.6000000 1.6521490 DDC;PLA2G1B
836 vasculature development (GO:0001944) 1/44 0.3576952 1.0000000 0 0 2.2727273 2.3365317 FLT4
837 neutrophil chemotaxis (GO:0030593) 1/44 0.3576952 1.0000000 0 0 2.2727273 2.3365317 PLA2G1B
838 branching involved in ureteric bud morphogenesis (GO:0001658) 1/44 0.3576952 1.0000000 0 0 2.2727273 2.3365317 GPC3
839 mesonephric tubule development (GO:0072164) 1/44 0.3576952 1.0000000 0 0 2.2727273 2.3365317 ROBO2
840 epithelial cell differentiation (GO:0030855) 4/303 0.3595502 1.0000000 0 0 1.3201320 1.3503648 SCUBE1;KRT4;DMRT1;TGM3
841 purine ribonucleotide biosynthetic process (GO:0009152) 2/126 0.3596902 1.0000000 0 0 1.5873016 1.6230353 NPPC;RAMP2
842 negative regulation of Wnt signaling pathway (GO:0030178) 2/126 0.3596902 1.0000000 0 0 1.5873016 1.6230353 FGF9;GPC3
843 cellular response to radiation (GO:0071478) 2/126 0.3596902 1.0000000 0 0 1.5873016 1.6230353 MFAP4;CNGA1
844 regulation of Wnt signaling pathway (GO:0030111) 3/214 0.3615322 1.0000000 0 0 1.4018692 1.4262677 FGF9;GPC3;LGR5
845 positive regulation of locomotion (GO:0040017) 4/304 0.3618189 1.0000000 0 0 1.3157895 1.3376467 FLT4;CCL5;ALOX12;GPR124
846 mesonephric epithelium development (GO:0072163) 1/45 0.3641324 1.0000000 0 0 2.2222222 2.2449725 ROBO2
847 regulation of interleukin-2 production (GO:0032663) 1/45 0.3641324 1.0000000 0 0 2.2222222 2.2449725 SFTPD
848 regulation of humoral immune response (GO:0002920) 1/45 0.3641324 1.0000000 0 0 2.2222222 2.2449725 PROS1
849 substantia nigra development (GO:0021762) 1/45 0.3641324 1.0000000 0 0 2.2222222 2.2449725 FGF9
850 cellular response to interleukin-1 (GO:0071347) 1/45 0.3641324 1.0000000 0 0 2.2222222 2.2449725 CCL5
851 excretion (GO:0007588) 1/45 0.3641324 1.0000000 0 0 2.2222222 2.2449725 KCNJ1
852 neutrophil migration (GO:1990266) 1/45 0.3641324 1.0000000 0 0 2.2222222 2.2449725 PLA2G1B
853 calcium ion transport (GO:0006816) 3/215 0.3642542 1.0000000 0 0 1.3953488 1.4091675 GPM6A;RAMP2;CCL5
854 positive regulation of endopeptidase activity (GO:0010950) 2/128 0.3668834 1.0000000 0 0 1.5625000 1.5667361 DLC1;ALOX12
855 regulation of protein binding (GO:0043393) 2/128 0.3668834 1.0000000 0 0 1.5625000 1.5667361 IFIT1;HOPX
856 tissue homeostasis (GO:0001894) 2/129 0.3704685 1.0000000 0 0 1.5503876 1.5395146 SFTPD;KCNJ1
857 negative regulation of developmental growth (GO:0048640) 1/46 0.3705054 1.0000000 0 0 2.1739130 2.1584503 GJA1
858 positive regulation of tyrosine phosphorylation of STAT protein (GO:0042531) 1/46 0.3705054 1.0000000 0 0 2.1739130 2.1584503 CCL5
859 inner ear development (GO:0048839) 1/46 0.3705054 1.0000000 0 0 2.1739130 2.1584503 LGR5
860 leukocyte cell-cell adhesion (GO:0007159) 1/46 0.3705054 1.0000000 0 0 2.1739130 2.1584503 CCL5
861 respiratory gaseous exchange (GO:0007585) 1/46 0.3705054 1.0000000 0 0 2.1739130 2.1584503 SFTPD
862 regulation of binding (GO:0051098) 3/218 0.3724090 1.0000000 0 0 1.3761468 1.3593063 IFIT1;HOPX;RUNX1T1
863 positive regulation of protein catabolic process (GO:0045732) 2/130 0.3740455 1.0000000 0 0 1.5384615 1.5128889 GJA1;GPC3
864 response to glucocorticoid (GO:0051384) 2/130 0.3740455 1.0000000 0 0 1.5384615 1.5128889 SCGB1A1;ABCG2
865 positive regulation of homeostatic process (GO:0032846) 2/130 0.3740455 1.0000000 0 0 1.5384615 1.5128889 MC4R;PLA2G1B
866 circulatory system process (GO:0003013) 2/130 0.3740455 1.0000000 0 0 1.5384615 1.5128889 NPPC;RAMP2
867 fatty acid beta-oxidation (GO:0006635) 1/47 0.3768149 1.0000000 0 0 2.1276596 2.0765984 ACOXL
868 regulation of synaptic transmission, glutamatergic (GO:0051966) 1/47 0.3768149 1.0000000 0 0 2.1276596 2.0765984 GRIK1
869 neural precursor cell proliferation (GO:0061351) 1/47 0.3768149 1.0000000 0 0 2.1276596 2.0765984 HHIP
870 negative regulation of synaptic transmission (GO:0050805) 1/47 0.3768149 1.0000000 0 0 2.1276596 2.0765984 GRIK1
871 acid secretion (GO:0046717) 1/47 0.3768149 1.0000000 0 0 2.1276596 2.0765984 PLA2G1B
872 skeletal muscle cell differentiation (GO:0035914) 1/47 0.3768149 1.0000000 0 0 2.1276596 2.0765984 HLF
873 cellular response to UV (GO:0034644) 1/47 0.3768149 1.0000000 0 0 2.1276596 2.0765984 MFAP4
874 negative regulation of growth (GO:0045926) 3/221 0.3805444 1.0000000 0 0 1.3574661 1.3115190 GJA1;GPC3;SCGB3A1
875 purine nucleotide biosynthetic process (GO:0006164) 2/132 0.3811749 1.0000000 0 0 1.5151515 1.4613592 NPPC;RAMP2
876 cellular response to biotic stimulus (GO:0071216) 2/132 0.3811749 1.0000000 0 0 1.5151515 1.4613592 CX3CR1;CCL5
877 positive regulation of alpha-beta T cell activation (GO:0046635) 1/48 0.3830614 1.0000000 0 0 2.0833333 1.9990833 HLA-DQB2
878 natural killer cell activation (GO:0030101) 1/48 0.3830614 1.0000000 0 0 2.0833333 1.9990833 KLRK1
879 intrinsic apoptotic signaling pathway by p53 class mediator (GO:0072332) 1/48 0.3830614 1.0000000 0 0 2.0833333 1.9990833 ZNF385B
880 regulation of mRNA stability (GO:0043488) 1/48 0.3830614 1.0000000 0 0 2.0833333 1.9990833 SCGB1A1
881 regulation of homeostatic process (GO:0032844) 4/314 0.3844827 1.0000000 0 0 1.2738854 1.2176516 MC4R;GJA1;PLA2G1B;ALOX12
882 regulation of blood pressure (GO:0008217) 2/133 0.3847268 1.0000000 0 0 1.5037594 1.4364239 RAMP2;OR51E2
883 positive regulation of immune effector process (GO:0002699) 2/133 0.3847268 1.0000000 0 0 1.5037594 1.4364239 KLRK1;CRTAM
884 cellular response to lipid (GO:0071396) 4/315 0.3867452 1.0000000 0 0 1.2698413 1.2063355 CX3CR1;CCL5;OR51E2;ALOX12
885 amine metabolic process (GO:0009308) 2/134 0.3882699 1.0000000 0 0 1.4925373 1.4120217 DDC;PLA2G1B
886 lipid modification (GO:0030258) 2/134 0.3882699 1.0000000 0 0 1.4925373 1.4120217 ACOXL;ALOX12
887 cellular response to drug (GO:0035690) 1/49 0.3892456 1.0000000 0 0 2.0408163 1.9256015 DDC
888 positive regulation of fibroblast proliferation (GO:0048146) 1/49 0.3892456 1.0000000 0 0 2.0408163 1.9256015 PLA2G1B
889 response to dsRNA (GO:0043331) 1/49 0.3892456 1.0000000 0 0 2.0408163 1.9256015 IFIT1
890 synapse assembly (GO:0007416) 1/49 0.3892456 1.0000000 0 0 2.0408163 1.9256015 GPM6A
891 developmental cell growth (GO:0048588) 1/49 0.3892456 1.0000000 0 0 2.0408163 1.9256015 DCX
892 regulation of lymphocyte apoptotic process (GO:0070228) 1/49 0.3892456 1.0000000 0 0 2.0408163 1.9256015 CCL5
893 antigen processing and presentation (GO:0019882) 3/225 0.3913564 1.0000000 0 0 1.3333333 1.2508489 CD207;HLA-DOA;HLA-DQB2
894 inositol lipid-mediated signaling (GO:0048017) 2/136 0.3953292 1.0000000 0 0 1.4705882 1.3647595 FGF9;FGF18
895 phosphatidylinositol-mediated signaling (GO:0048015) 2/136 0.3953292 1.0000000 0 0 1.4705882 1.3647595 FGF9;FGF18
896 cellular modified amino acid biosynthetic process (GO:0042398) 1/50 0.3953682 1.0000000 0 0 2.0000000 1.8558758 PADI3
897 endothelial cell migration (GO:0043542) 1/50 0.3953682 1.0000000 0 0 2.0000000 1.8558758 GPR124
898 regulation of cell junction assembly (GO:1901888) 1/50 0.3953682 1.0000000 0 0 2.0000000 1.8558758 GJA1
899 negative regulation of protein binding (GO:0032091) 1/50 0.3953682 1.0000000 0 0 2.0000000 1.8558758 IFIT1
900 cell projection morphogenesis (GO:0048858) 3/228 0.3994350 1.0000000 0 0 1.3157895 1.2075055 GPM6A;GJA1;DCX
901 positive regulation of proteolysis (GO:0045862) 3/228 0.3994350 1.0000000 0 0 1.3157895 1.2075055 PCOLCE2;DLC1;ALOX12
902 response to lipopolysaccharide (GO:0032496) 3/228 0.3994350 1.0000000 0 0 1.3157895 1.2075055 CX3CR1;CCL5;SCGB1A1
903 positive regulation of phosphatidylinositol 3-kinase signaling (GO:0014068) 1/51 0.4014296 1.0000000 0 0 1.9607843 1.7896531 CCL5
904 regulation of potassium ion transport (GO:0043266) 1/51 0.4014296 1.0000000 0 0 1.9607843 1.7896531 KCNJ1
905 regulation of glucose import (GO:0046324) 1/51 0.4014296 1.0000000 0 0 1.9607843 1.7896531 GPC3
906 regulation of neurotransmitter secretion (GO:0046928) 1/51 0.4014296 1.0000000 0 0 1.9607843 1.7896531 SNCG
907 positive regulation of axonogenesis (GO:0050772) 1/51 0.4014296 1.0000000 0 0 1.9607843 1.7896531 ROBO2
908 regulation of RNA stability (GO:0043487) 1/51 0.4014296 1.0000000 0 0 1.9607843 1.7896531 SCGB1A1
909 negative regulation of response to wounding (GO:1903035) 2/138 0.4023514 1.0000000 0 0 1.4492754 1.3194631 PROS1;ALOX12
910 response to light stimulus (GO:0009416) 4/322 0.4025512 1.0000000 0 0 1.2422360 1.1303516 MFAP4;OPN1SW;GPC3;CNGA1
911 endocytosis (GO:0006897) 4/323 0.4048039 1.0000000 0 0 1.2383901 1.1199413 RAMP2;SFTPD;CLEC4F;LRP1B
912 regulation of hormone secretion (GO:0046883) 3/230 0.4048048 1.0000000 0 0 1.3043478 1.1795874 KISS1;CCL5;SCG5
913 negative regulation of peptidase activity (GO:0010466) 3/230 0.4048048 1.0000000 0 0 1.3043478 1.1795874 PROS1;GPC3;A2ML1
914 protein homooligomerization (GO:0051260) 3/230 0.4048048 1.0000000 0 0 1.3043478 1.1795874 SCUBE1;KCNA3;KCNA4
915 immune response-activating cell surface receptor signaling pathway (GO:0002429) 4/324 0.4070550 1.0000000 0 0 1.2345679 1.1096382 IGHG4;TRAC;SKAP1;HLA-DQB2
916 positive regulation of epithelial cell differentiation (GO:0030858) 1/52 0.4074306 1.0000000 0 0 1.9230769 1.7267012 ALOX12
917 defense response to Gram-positive bacterium (GO:0050830) 1/52 0.4074306 1.0000000 0 0 1.9230769 1.7267012 PLA2G1B
918 demethylation (GO:0070988) 1/52 0.4074306 1.0000000 0 0 1.9230769 1.7267012 APOBEC2
919 regulation of pH (GO:0006885) 1/52 0.4074306 1.0000000 0 0 1.9230769 1.7267012 SLC4A10
920 regulation of vasoconstriction (GO:0019229) 1/52 0.4074306 1.0000000 0 0 1.9230769 1.7267012 GJA1
921 regulation of excitatory postsynaptic membrane potential (GO:0060079) 1/52 0.4074306 1.0000000 0 0 1.9230769 1.7267012 GRIK1
922 regulation of phagocytosis (GO:0050764) 1/52 0.4074306 1.0000000 0 0 1.9230769 1.7267012 SFTPD
923 positive regulation of lipid biosynthetic process (GO:0046889) 1/52 0.4074306 1.0000000 0 0 1.9230769 1.7267012 FABP3
924 regulation of interleukin-8 production (GO:0032677) 1/52 0.4074306 1.0000000 0 0 1.9230769 1.7267012 BPI
925 positive regulation of protein transport (GO:0051222) 3/231 0.4074846 1.0000000 0 0 1.2987013 1.1659119 PLA2G1B;CRTAM;OR51E2
926 ribonucleotide biosynthetic process (GO:0009260) 2/140 0.4093351 1.0000000 0 0 1.4285714 1.2760304 NPPC;RAMP2
927 response to corticosteroid (GO:0031960) 2/140 0.4093351 1.0000000 0 0 1.4285714 1.2760304 SCGB1A1;ABCG2
928 multi-organism reproductive process (GO:0044703) 2/140 0.4093351 1.0000000 0 0 1.4285714 1.2760304 RAMP2;SCGB1A1
929 cell-substrate adhesion (GO:0031589) 2/140 0.4093351 1.0000000 0 0 1.4285714 1.2760304 ECM2;PPFIA2
930 adult behavior (GO:0030534) 2/141 0.4128121 1.0000000 0 0 1.4184397 1.2549827 SNCG;GRIK1
931 branching morphogenesis of an epithelial tube (GO:0048754) 2/141 0.4128121 1.0000000 0 0 1.4184397 1.2549827 HHIP;GPC3
932 forebrain development (GO:0030900) 1/53 0.4133717 1.0000000 0 0 1.8867925 1.6668075 DLC1
933 regulation of tyrosine phosphorylation of STAT protein (GO:0042509) 1/53 0.4133717 1.0000000 0 0 1.8867925 1.6668075 CCL5
934 pyridine nucleotide metabolic process (GO:0019362) 1/53 0.4133717 1.0000000 0 0 1.8867925 1.6668075 QPRT
935 regulation of protein tyrosine kinase activity (GO:0061097) 1/53 0.4133717 1.0000000 0 0 1.8867925 1.6668075 CCL5
936 nicotinamide nucleotide metabolic process (GO:0046496) 1/53 0.4133717 1.0000000 0 0 1.8867925 1.6668075 QPRT
937 lymphocyte mediated immunity (GO:0002449) 1/53 0.4133717 1.0000000 0 0 1.8867925 1.6668075 CRTAM
938 divalent metal ion transport (GO:0070838) 3/234 0.4155023 1.0000000 0 0 1.2820513 1.1259834 GPM6A;RAMP2;CCL5
939 homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156) 2/142 0.4162790 1.0000000 0 0 1.4084507 1.2343655 ROBO2;CDH7
940 digestive tract development (GO:0048565) 1/54 0.4192536 1.0000000 0 0 1.8518519 1.6097765 FGF9
941 negative regulation of nuclear division (GO:0051784) 1/54 0.4192536 1.0000000 0 0 1.8518519 1.6097765 DMRT1
942 peptide hormone secretion (GO:0030072) 1/54 0.4192536 1.0000000 0 0 1.8518519 1.6097765 MC4R
943 keratinocyte differentiation (GO:0030216) 1/54 0.4192536 1.0000000 0 0 1.8518519 1.6097765 TGM3
944 regulation of cartilage development (GO:0061035) 1/54 0.4192536 1.0000000 0 0 1.8518519 1.6097765 FGF18
945 ribose phosphate biosynthetic process (GO:0046390) 2/144 0.4231821 1.0000000 0 0 1.3888889 1.1943787 NPPC;RAMP2
946 positive regulation of epithelial cell proliferation (GO:0050679) 2/144 0.4231821 1.0000000 0 0 1.3888889 1.1943787 FGF9;FLT4
947 positive regulation of nuclear division (GO:0051785) 1/55 0.4250768 1.0000000 0 0 1.8181818 1.5554281 DMRT1
948 peptidyl-proline modification (GO:0018208) 1/55 0.4250768 1.0000000 0 0 1.8181818 1.5554281 P4HA3
949 arachidonic acid metabolic process (GO:0019369) 1/55 0.4250768 1.0000000 0 0 1.8181818 1.5554281 ALOX12
950 embryonic digit morphogenesis (GO:0042733) 1/55 0.4250768 1.0000000 0 0 1.8181818 1.5554281 GJA1
951 mesenchyme development (GO:0060485) 1/55 0.4250768 1.0000000 0 0 1.8181818 1.5554281 FGF9
952 heart looping (GO:0001947) 1/55 0.4250768 1.0000000 0 0 1.8181818 1.5554281 GJA1
953 divalent inorganic cation transport (GO:0072511) 3/238 0.4261388 1.0000000 0 0 1.2605042 1.0751978 GPM6A;RAMP2;CCL5
954 purine-containing compound biosynthetic process (GO:0072522) 2/146 0.4300432 1.0000000 0 0 1.3698630 1.1559858 NPPC;RAMP2
955 regulation of stress fiber assembly (GO:0051492) 1/56 0.4308418 1.0000000 0 0 1.7857143 1.5035968 DLC1
956 peptide secretion (GO:0002790) 1/56 0.4308418 1.0000000 0 0 1.7857143 1.5035968 MC4R
957 positive regulation of JAK-STAT cascade (GO:0046427) 1/56 0.4308418 1.0000000 0 0 1.7857143 1.5035968 CCL5
958 positive regulation of leukocyte chemotaxis (GO:0002690) 1/56 0.4308418 1.0000000 0 0 1.7857143 1.5035968 CCL5
959 DNA methylation or demethylation (GO:0044728) 1/56 0.4308418 1.0000000 0 0 1.7857143 1.5035968 APOBEC2
960 positive regulation of protein processing (GO:0010954) 3/240 0.4314322 1.0000000 0 0 1.2500000 1.0508061 PCOLCE2;DLC1;ALOX12
961 positive regulation of protein maturation (GO:1903319) 3/240 0.4314322 1.0000000 0 0 1.2500000 1.0508061 PCOLCE2;DLC1;ALOX12
962 cellular response to acid chemical (GO:0071229) 2/147 0.4334576 1.0000000 0 0 1.3605442 1.1373622 OR51E2;SNCG
963 response to hypoxia (GO:0001666) 3/241 0.4340724 1.0000000 0 0 1.2448133 1.0388512 NPPC;RAMP2;KCNK3
964 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains (GO:0002460) 1/57 0.4365494 1.0000000 0 0 1.7543860 1.4541294 CRTAM
965 actomyosin structure organization (GO:0031032) 1/57 0.4365494 1.0000000 0 0 1.7543860 1.4541294 MYOZ1
966 establishment of synaptic vesicle localization (GO:0097480) 1/57 0.4365494 1.0000000 0 0 1.7543860 1.4541294 DDC
967 synaptic vesicle transport (GO:0048489) 1/57 0.4365494 1.0000000 0 0 1.7543860 1.4541294 DDC
968 insulin receptor signaling pathway (GO:0008286) 2/148 0.4368612 1.0000000 0 0 1.3513514 1.1191078 FGF9;FGF18
969 response to molecule of bacterial origin (GO:0002237) 3/243 0.4393395 1.0000000 0 0 1.2345679 1.0154110 CX3CR1;CCL5;SCGB1A1
970 regulation of cell-substrate adhesion (GO:0010810) 2/149 0.4402537 1.0000000 0 0 1.3422819 1.1012136 SMOC2;ECM2
971 regulation of postsynaptic membrane potential (GO:0060078) 1/58 0.4422000 1.0000000 0 0 1.7241379 1.4068845 GRIK1
972 regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001239) 1/58 0.4422000 1.0000000 0 0 1.7241379 1.4068845 CX3CR1
973 response to decreased oxygen levels (GO:0036293) 3/245 0.4445880 1.0000000 0 0 1.2244898 0.9925803 NPPC;RAMP2;KCNK3
974 regulation of synaptic transmission (GO:0050804) 3/245 0.4445880 1.0000000 0 0 1.2244898 0.9925803 KISS1;SNCG;GRIK1
975 cellular response to nitrogen compound (GO:1901699) 5/438 0.4461310 1.0000000 0 0 1.1415525 0.9213957 DDC;FGF9;PLA2G1B;FGF18;IFIT1
976 positive regulation of osteoblast differentiation (GO:0045669) 1/59 0.4477942 1.0000000 0 0 1.6949153 1.3617314 NPPC
977 chondroitin sulfate metabolic process (GO:0030204) 1/59 0.4477942 1.0000000 0 0 1.6949153 1.3617314 GPC3
978 steroid hormone mediated signaling pathway (GO:0043401) 1/59 0.4477942 1.0000000 0 0 1.6949153 1.3617314 OR51E2
979 regulation of inflammatory response (GO:0050727) 3/247 0.4498174 1.0000000 0 0 1.2145749 0.9703403 PROS1;CCL5;SCGB1A1
980 cell part morphogenesis (GO:0032990) 3/248 0.4524247 1.0000000 0 0 1.2096774 0.9594361 GPM6A;GJA1;DCX
981 glycosaminoglycan catabolic process (GO:0006027) 1/60 0.4533326 1.0000000 0 0 1.6666667 1.3185487 GPC3
982 cellular defense response (GO:0006968) 1/60 0.4533326 1.0000000 0 0 1.6666667 1.3185487 CX3CR1
983 positive regulation of DNA replication (GO:0045740) 1/60 0.4533326 1.0000000 0 0 1.6666667 1.3185487 PLA2G1B
984 inner ear morphogenesis (GO:0042472) 1/60 0.4533326 1.0000000 0 0 1.6666667 1.3185487 FGF9
985 pyridine-containing compound metabolic process (GO:0072524) 1/61 0.4588157 1.0000000 0 0 1.6393443 1.2772240 QPRT
986 cholesterol homeostasis (GO:0042632) 1/61 0.4588157 1.0000000 0 0 1.6393443 1.2772240 FABP3
987 double-strand break repair via homologous recombination (GO:0000724) 1/61 0.4588157 1.0000000 0 0 1.6393443 1.2772240 MEIOB
988 kidney epithelium development (GO:0072073) 1/62 0.4642441 1.0000000 0 0 1.6129032 1.2376529 ROBO2
989 regulation of adenylate cyclase activity (GO:0045761) 1/62 0.4642441 1.0000000 0 0 1.6129032 1.2376529 GABBR2
990 embryonic heart tube morphogenesis (GO:0003143) 1/62 0.4642441 1.0000000 0 0 1.6129032 1.2376529 GJA1
991 regulation of cation channel activity (GO:2001257) 1/62 0.4642441 1.0000000 0 0 1.6129032 1.2376529 KCNJ1
992 recombinational repair (GO:0000725) 1/62 0.4642441 1.0000000 0 0 1.6129032 1.2376529 MEIOB
993 negative regulation of G-protein coupled receptor protein signaling pathway (GO:0045744) 1/62 0.4642441 1.0000000 0 0 1.6129032 1.2376529 CCL5
994 phosphatidylcholine metabolic process (GO:0046470) 1/62 0.4642441 1.0000000 0 0 1.6129032 1.2376529 PLA2G1B
995 regulation of actin filament bundle assembly (GO:0032231) 1/62 0.4642441 1.0000000 0 0 1.6129032 1.2376529 DLC1
996 sterol homeostasis (GO:0055092) 1/62 0.4642441 1.0000000 0 0 1.6129032 1.2376529 FABP3
997 stem cell differentiation (GO:0048863) 1/62 0.4642441 1.0000000 0 0 1.6129032 1.2376529 GPM6A
998 regulation of innate immune response (GO:0045088) 3/254 0.4679607 1.0000000 0 0 1.1811024 0.8968947 KLRK1;CCL5;CRTAM
999 regulation of alpha-beta T cell activation (GO:0046634) 1/63 0.4696183 1.0000000 0 0 1.5873016 1.1997381 HLA-DQB2
1000 modification of morphology or physiology of other organism involved in symbiotic interaction (GO:0051817) 1/63 0.4696183 1.0000000 0 0 1.5873016 1.1997381 CCL5
1001 positive regulation of endothelial cell proliferation (GO:0001938) 1/63 0.4696183 1.0000000 0 0 1.5873016 1.1997381 FLT4
1002 regulation of blood vessel size (GO:0050880) 1/63 0.4696183 1.0000000 0 0 1.5873016 1.1997381 NPPC
1003 neural nucleus development (GO:0048857) 1/63 0.4696183 1.0000000 0 0 1.5873016 1.1997381 FGF9
1004 regulation of neurotransmitter transport (GO:0051588) 1/63 0.4696183 1.0000000 0 0 1.5873016 1.1997381 SNCG
1005 energy reserve metabolic process (GO:0006112) 2/158 0.4702715 1.0000000 0 0 1.2658228 0.9549937 MC4R;LEPR
1006 epithelium development (GO:0060429) 3/256 0.4730965 1.0000000 0 0 1.1718750 0.8770968 ROBO2;GJA1;EMP1
1007 regulation of endopeptidase activity (GO:0052548) 4/354 0.4735741 1.0000000 0 0 1.1299435 0.8445728 DLC1;PROS1;ALOX12;A2ML1
1008 negative regulation of angiogenesis (GO:0016525) 1/64 0.4749389 1.0000000 0 0 1.5625000 1.1633893 CX3CR1
1009 fatty acid catabolic process (GO:0009062) 1/64 0.4749389 1.0000000 0 0 1.5625000 1.1633893 ACOXL
1010 regulation of tube size (GO:0035150) 1/64 0.4749389 1.0000000 0 0 1.5625000 1.1633893 NPPC
1011 regulation of synapse organization (GO:0050807) 1/64 0.4749389 1.0000000 0 0 1.5625000 1.1633893 ROBO2
1012 positive regulation of stem cell proliferation (GO:2000648) 1/64 0.4749389 1.0000000 0 0 1.5625000 1.1633893 FGF9
1013 meiotic nuclear division (GO:0007126) 1/64 0.4749389 1.0000000 0 0 1.5625000 1.1633893 MEIOB
1014 multicellular organismal development (GO:0007275) 5/453 0.4752146 1.0000000 0 0 1.1037528 0.8211796 ST6GAL2;HLF;LEPR;EMP1;TBX4
1015 epithelial cell migration (GO:0010631) 1/65 0.4802063 1.0000000 0 0 1.5384615 1.1285222 GPR124
1016 negative regulation of phosphatase activity (GO:0010923) 1/65 0.4802063 1.0000000 0 0 1.5384615 1.1285222 SLC7A14
1017 oxidoreduction coenzyme metabolic process (GO:0006733) 1/65 0.4802063 1.0000000 0 0 1.5384615 1.1285222 QPRT
1018 positive regulation of peptide hormone secretion (GO:0090277) 1/65 0.4802063 1.0000000 0 0 1.5384615 1.1285222 KISS1
1019 response to oxygen levels (GO:0070482) 3/259 0.4807580 1.0000000 0 0 1.1583012 0.8483297 NPPC;RAMP2;KCNK3
1020 tissue morphogenesis (GO:0048729) 4/358 0.4822501 1.0000000 0 0 1.1173184 0.8148519 GJA1;HHIP;GPC3;TBX4
1021 morphogenesis of a branching epithelium (GO:0061138) 2/162 0.4833031 1.0000000 0 0 1.2345679 0.8976684 HHIP;GPC3
1022 skeletal system development (GO:0001501) 2/162 0.4833031 1.0000000 0 0 1.2345679 0.8976684 FGF9;FBN1
1023 regulation of acute inflammatory response (GO:0002673) 1/66 0.4854212 1.0000000 0 0 1.5151515 1.0950581 PROS1
1024 negative regulation of cell division (GO:0051782) 1/66 0.4854212 1.0000000 0 0 1.5151515 1.0950581 DMRT1
1025 regulation of translational initiation (GO:0006446) 1/66 0.4854212 1.0000000 0 0 1.5151515 1.0950581 CCL5
1026 regulation of bone mineralization (GO:0030500) 1/66 0.4854212 1.0000000 0 0 1.5151515 1.0950581 GJA1
1027 regulation of phosphatidylinositol 3-kinase signaling (GO:0014066) 1/66 0.4854212 1.0000000 0 0 1.5151515 1.0950581 CCL5
1028 positive regulation of translation (GO:0045727) 1/66 0.4854212 1.0000000 0 0 1.5151515 1.0950581 CCL5
1029 dorsal/ventral pattern formation (GO:0009953) 1/66 0.4854212 1.0000000 0 0 1.5151515 1.0950581 HHIP
1030 negative regulation of blood vessel morphogenesis (GO:2000181) 1/66 0.4854212 1.0000000 0 0 1.5151515 1.0950581 CX3CR1
1031 multicellular organismal response to stress (GO:0033555) 1/66 0.4854212 1.0000000 0 0 1.5151515 1.0950581 GRIK1
1032 response to ammonium ion (GO:0060359) 1/66 0.4854212 1.0000000 0 0 1.5151515 1.0950581 SNCG
1033 cellular response to peptide hormone stimulus (GO:0071375) 3/261 0.4858368 1.0000000 0 0 1.1494253 0.8297501 FGF9;PLA2G1B;FGF18
1034 fibroblast growth factor receptor signaling pathway (GO:0008543) 2/163 0.4865301 1.0000000 0 0 1.2269939 0.8839957 FGF9;FGF18
1035 developmental growth (GO:0048589) 2/163 0.4865301 1.0000000 0 0 1.2269939 0.8839957 GJA1;DCX
1036 tube development (GO:0035295) 2/164 0.4897447 1.0000000 0 0 1.2195122 0.8705745 ROBO2;FGF9
1037 vasculogenesis (GO:0001570) 1/67 0.4905840 1.0000000 0 0 1.4925373 1.0629235 RAMP2
1038 aminoglycan catabolic process (GO:0006026) 1/67 0.4905840 1.0000000 0 0 1.4925373 1.0629235 GPC3
1039 protein secretion (GO:0009306) 1/67 0.4905840 1.0000000 0 0 1.4925373 1.0629235 SNCG
1040 cellular iron ion homeostasis (GO:0006879) 1/67 0.4905840 1.0000000 0 0 1.4925373 1.0629235 ABCG2
1041 cellular response to mechanical stimulus (GO:0071260) 1/67 0.4905840 1.0000000 0 0 1.4925373 1.0629235 GJA1
1042 positive regulation of peptide secretion (GO:0002793) 1/67 0.4905840 1.0000000 0 0 1.4925373 1.0629235 KISS1
1043 regulation of endocytosis (GO:0030100) 2/165 0.4929467 1.0000000 0 0 1.2121212 0.8573991 SFTPD;GPC3
1044 cytokine production (GO:0001816) 1/68 0.4956953 1.0000000 0 0 1.4705882 1.0320498 PLA2G1B
1045 regulation of leukocyte chemotaxis (GO:0002688) 1/68 0.4956953 1.0000000 0 0 1.4705882 1.0320498 CCL5
1046 glucose transport (GO:0015758) 1/68 0.4956953 1.0000000 0 0 1.4705882 1.0320498 PLA2G1B
1047 regulation of DNA metabolic process (GO:0051052) 3/265 0.4959228 1.0000000 0 0 1.1320755 0.7939642 NPPC;APOBEC3H;PLA2G1B
1048 negative regulation of cell migration (GO:0030336) 2/166 0.4961360 1.0000000 0 0 1.2048193 0.8444640 CX3CR1;DLC1
1049 regulation of membrane potential (GO:0042391) 3/266 0.4984290 1.0000000 0 0 1.1278195 0.7852941 GJA1;CNGA1;GRIK1
1050 hexose transport (GO:0008645) 1/69 0.5007555 1.0000000 0 0 1.4492754 1.0023729 PLA2G1B
1051 molting cycle process (GO:0022404) 1/69 0.5007555 1.0000000 0 0 1.4492754 1.0023729 TGM3
1052 positive regulation of cytokine secretion (GO:0050715) 1/69 0.5007555 1.0000000 0 0 1.4492754 1.0023729 CRTAM
1053 hair cycle process (GO:0022405) 1/69 0.5007555 1.0000000 0 0 1.4492754 1.0023729 TGM3
1054 alpha-amino acid biosynthetic process (GO:1901607) 1/69 0.5007555 1.0000000 0 0 1.4492754 1.0023729 PADI3
1055 action potential (GO:0001508) 1/69 0.5007555 1.0000000 0 0 1.4492754 1.0023729 GJA1
1056 hormone secretion (GO:0046879) 1/70 0.5057652 1.0000000 0 0 1.4285714 0.9738324 MC4R
1057 negative regulation of dephosphorylation (GO:0035305) 1/70 0.5057652 1.0000000 0 0 1.4285714 0.9738324 SLC7A14
1058 response to heat (GO:0009408) 1/70 0.5057652 1.0000000 0 0 1.4285714 0.9738324 STAC
1059 positive regulation of muscle cell differentiation (GO:0051149) 1/70 0.5057652 1.0000000 0 0 1.4285714 0.9738324 HOPX
1060 negative regulation of vasculature development (GO:1901343) 1/70 0.5057652 1.0000000 0 0 1.4285714 0.9738324 CX3CR1
1061 response to steroid hormone (GO:0048545) 4/369 0.5058127 1.0000000 0 0 1.0840108 0.7388497 RAMP2;OR51E2;SCGB1A1;ABCG2
1062 response to inorganic substance (GO:0010035) 4/370 0.5079318 1.0000000 0 0 1.0810811 0.7323331 SCGB1A1;SNCG;KCNK3;ABCG2
1063 negative regulation of cell motility (GO:2000146) 2/170 0.5087658 1.0000000 0 0 1.1764706 0.7950205 CX3CR1;DLC1
1064 MAPK cascade (GO:0000165) 2/170 0.5087658 1.0000000 0 0 1.1764706 0.7950205 DOK5;CCL5
1065 morphogenesis of a branching structure (GO:0001763) 2/170 0.5087658 1.0000000 0 0 1.1764706 0.7950205 HHIP;GPC3
1066 tissue remodeling (GO:0048771) 1/71 0.5107249 1.0000000 0 0 1.4084507 0.9463720 GJA1
1067 response to interleukin-1 (GO:0070555) 1/71 0.5107249 1.0000000 0 0 1.4084507 0.9463720 CCL5
1068 single-organism nuclear import (GO:1902593) 1/71 0.5107249 1.0000000 0 0 1.4084507 0.9463720 FGF9
1069 regulation of leukocyte apoptotic process (GO:2000106) 1/71 0.5107249 1.0000000 0 0 1.4084507 0.9463720 CCL5
1070 receptor metabolic process (GO:0043112) 1/71 0.5107249 1.0000000 0 0 1.4084507 0.9463720 RAMP2
1071 monosaccharide transport (GO:0015749) 1/71 0.5107249 1.0000000 0 0 1.4084507 0.9463720 PLA2G1B
1072 organophosphate ester transport (GO:0015748) 1/71 0.5107249 1.0000000 0 0 1.4084507 0.9463720 GJA1
1073 positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains (GO:0002824) 1/71 0.5107249 1.0000000 0 0 1.4084507 0.9463720 HLA-DQB2
1074 protein import into nucleus (GO:0006606) 1/71 0.5107249 1.0000000 0 0 1.4084507 0.9463720 FGF9
1075 biomineral tissue development (GO:0031214) 1/71 0.5107249 1.0000000 0 0 1.4084507 0.9463720 GPC3
1076 monocarboxylic acid metabolic process (GO:0032787) 5/473 0.5131956 1.0000000 0 0 1.0570825 0.7051778 CH25H;FABP3;ACOXL;PLA2G1B;ALOX12
1077 smoothened signaling pathway (GO:0007224) 1/72 0.5156351 1.0000000 0 0 1.3888889 0.9199388 HHIP
1078 regulation of fatty acid metabolic process (GO:0019217) 1/72 0.5156351 1.0000000 0 0 1.3888889 0.9199388 FABP3
1079 regulation of multicellular organism growth (GO:0040014) 1/72 0.5156351 1.0000000 0 0 1.3888889 0.9199388 NPPC
1080 regulation of calcium ion transport into cytosol (GO:0010522) 1/72 0.5156351 1.0000000 0 0 1.3888889 0.9199388 PLA2G1B
1081 negative regulation of purine nucleotide metabolic process (GO:1900543) 1/72 0.5156351 1.0000000 0 0 1.3888889 0.9199388 GABBR2
1082 regulation of biomineral tissue development (GO:0070167) 1/72 0.5156351 1.0000000 0 0 1.3888889 0.9199388 GJA1
1083 peptide transport (GO:0015833) 1/72 0.5156351 1.0000000 0 0 1.3888889 0.9199388 MC4R
1084 cellular response to peptide (GO:1901653) 3/273 0.5157953 1.0000000 0 0 1.0989011 0.7275222 FGF9;PLA2G1B;FGF18
1085 regulation of ossification (GO:0030278) 2/173 0.5181024 1.0000000 0 0 1.1560694 0.7602108 NPPC;GJA1
1086 positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway (GO:0090100) 1/73 0.5204962 1.0000000 0 0 1.3698630 0.8944830 GPC3
1087 regulation of cyclase activity (GO:0031279) 1/73 0.5204962 1.0000000 0 0 1.3698630 0.8944830 GABBR2
1088 positive regulation of adaptive immune response (GO:0002821) 1/74 0.5253088 1.0000000 0 0 1.3513514 0.8699580 HLA-DQB2
1089 nuclear import (GO:0051170) 1/75 0.5300734 1.0000000 0 0 1.3333333 0.8463198 FGF9
1090 regulation of fibroblast proliferation (GO:0048145) 1/75 0.5300734 1.0000000 0 0 1.3333333 0.8463198 PLA2G1B
1091 muscle cell development (GO:0055001) 1/75 0.5300734 1.0000000 0 0 1.3333333 0.8463198 RAMP2
1092 negative regulation of nucleotide metabolic process (GO:0045980) 1/75 0.5300734 1.0000000 0 0 1.3333333 0.8463198 GABBR2
1093 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:0002479) 1/75 0.5300734 1.0000000 0 0 1.3333333 0.8463198 CD207
1094 hormone transport (GO:0009914) 1/75 0.5300734 1.0000000 0 0 1.3333333 0.8463198 MC4R
1095 response to vitamin (GO:0033273) 1/75 0.5300734 1.0000000 0 0 1.3333333 0.8463198 ABCG2
1096 regulation of cellular ketone metabolic process (GO:0010565) 2/178 0.5334006 1.0000000 0 0 1.1235955 0.7061602 FABP3;LEPR
1097 regulation of JAK-STAT cascade (GO:0046425) 1/76 0.5347903 1.0000000 0 0 1.3157895 0.8235271 CCL5
1098 neural tube closure (GO:0001843) 1/76 0.5347903 1.0000000 0 0 1.3157895 0.8235271 DLC1
1099 modification of morphology or physiology of other organism (GO:0035821) 1/76 0.5347903 1.0000000 0 0 1.3157895 0.8235271 CCL5
1100 epidermal cell differentiation (GO:0009913) 1/76 0.5347903 1.0000000 0 0 1.3157895 0.8235271 TGM3
1101 regulation of viral transcription (GO:0046782) 1/76 0.5347903 1.0000000 0 0 1.3157895 0.8235271 CCL5
1102 tube closure (GO:0060606) 1/77 0.5394601 1.0000000 0 0 1.2987013 0.8015408 DLC1
1103 regulation of lyase activity (GO:0051339) 1/77 0.5394601 1.0000000 0 0 1.2987013 0.8015408 GABBR2
1104 regulation of DNA binding (GO:0051101) 1/77 0.5394601 1.0000000 0 0 1.2987013 0.8015408 RUNX1T1
1105 protein localization to plasma membrane (GO:0072659) 1/77 0.5394601 1.0000000 0 0 1.2987013 0.8015408 RAMP2
1106 axis specification (GO:0009798) 1/78 0.5440833 1.0000000 0 0 1.2820513 0.7803242 GPC3
1107 positive regulation of leukocyte migration (GO:0002687) 1/78 0.5440833 1.0000000 0 0 1.2820513 0.7803242 CCL5
1108 regulation of tumor necrosis factor production (GO:0032680) 1/78 0.5440833 1.0000000 0 0 1.2820513 0.7803242 BPI
1109 negative regulation of cellular component movement (GO:0051271) 2/183 0.5483655 1.0000000 0 0 1.0928962 0.6566265 CX3CR1;DLC1
1110 locomotory behavior (GO:0007626) 2/183 0.5483655 1.0000000 0 0 1.0928962 0.6566265 SNCG;FEZF2
1111 developmental growth involved in morphogenesis (GO:0060560) 1/79 0.5486603 1.0000000 0 0 1.2658228 0.7598427 DCX
1112 regulation of interferon-gamma production (GO:0032649) 1/79 0.5486603 1.0000000 0 0 1.2658228 0.7598427 SCGB1A1
1113 antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) 1/79 0.5486603 1.0000000 0 0 1.2658228 0.7598427 CD207
1114 regulation of carbohydrate biosynthetic process (GO:0043255) 1/79 0.5486603 1.0000000 0 0 1.2658228 0.7598427 LEPR
1115 behavior (GO:0007610) 5/494 0.5518315 1.0000000 0 0 1.0121457 0.6017334 MC4R;GRID1;SNCG;GRIK1;FEZF2
1116 regulation of tumor necrosis factor superfamily cytokine production (GO:1903555) 1/80 0.5531916 1.0000000 0 0 1.2500000 0.7400636 BPI
1117 multicellular organismal catabolic process (GO:0044243) 1/80 0.5531916 1.0000000 0 0 1.2500000 0.7400636 PLA2G1B
1118 regulation of cysteine-type endopeptidase activity involved in apoptotic process (GO:0043281) 2/186 0.5571827 1.0000000 0 0 1.0752688 0.6288839 DLC1;ALOX12
1119 small molecule biosynthetic process (GO:0044283) 4/394 0.5575014 1.0000000 0 0 1.0152284 0.5931881 CH25H;PLA2G1B;PADI3;ALOX12
1120 lymphocyte proliferation (GO:0046651) 1/81 0.5576776 1.0000000 0 0 1.2345679 0.7209558 CRTAM
1121 negative regulation of immune effector process (GO:0002698) 1/81 0.5576776 1.0000000 0 0 1.2345679 0.7209558 IFIT1
1122 platelet degranulation (GO:0002576) 1/81 0.5576776 1.0000000 0 0 1.2345679 0.7209558 PROS1
1123 phenol-containing compound metabolic process (GO:0018958) 1/81 0.5576776 1.0000000 0 0 1.2345679 0.7209558 DDC
1124 ethanolamine-containing compound metabolic process (GO:0042439) 1/81 0.5576776 1.0000000 0 0 1.2345679 0.7209558 PLA2G1B
1125 cellular response to organic cyclic compound (GO:0071407) 3/291 0.5589306 1.0000000 0 0 1.0309278 0.5997217 CCL5;OR51E2;IFIT1
1126 monocarboxylic acid catabolic process (GO:0072329) 1/82 0.5621188 1.0000000 0 0 1.2195122 0.7024903 ACOXL
1127 male gonad development (GO:0008584) 1/82 0.5621188 1.0000000 0 0 1.2195122 0.7024903 FGF9
1128 monovalent inorganic cation homeostasis (GO:0055067) 1/82 0.5621188 1.0000000 0 0 1.2195122 0.7024903 SLC4A10
1129 regulation of peptide hormone secretion (GO:0090276) 2/189 0.5658778 1.0000000 0 0 1.0582011 0.6025155 KISS1;CCL5
1130 negative regulation of protein kinase activity (GO:0006469) 2/189 0.5658778 1.0000000 0 0 1.0582011 0.6025155 CAMK2N1;DUSP26
1131 positive regulation of T cell proliferation (GO:0042102) 1/83 0.5665156 1.0000000 0 0 1.2048193 0.6846392 CCL5
1132 positive regulation of ossification (GO:0045778) 1/83 0.5665156 1.0000000 0 0 1.2048193 0.6846392 NPPC
1133 myeloid leukocyte differentiation (GO:0002573) 1/83 0.5665156 1.0000000 0 0 1.2048193 0.6846392 GPC3
1134 activation of cysteine-type endopeptidase activity involved in apoptotic process (GO:0006919) 1/83 0.5665156 1.0000000 0 0 1.2048193 0.6846392 DLC1
1135 amide transport (GO:0042886) 1/83 0.5665156 1.0000000 0 0 1.2048193 0.6846392 MC4R
1136 mononuclear cell proliferation (GO:0032943) 1/83 0.5665156 1.0000000 0 0 1.2048193 0.6846392 CRTAM
1137 cell-cell adhesion via plasma-membrane adhesion molecules (GO:0098742) 2/190 0.5687489 1.0000000 0 0 1.0526316 0.5940172 ROBO2;CDH7
1138 regulation of interleukin-6 production (GO:0032675) 1/84 0.5708685 1.0000000 0 0 1.1904762 0.6673766 BPI
1139 cell-cell adhesion (GO:0098609) 2/191 0.5716063 1.0000000 0 0 1.0471204 0.5856595 ROBO2;CDH7
1140 regulation of peptide secretion (GO:0002791) 2/192 0.5744500 1.0000000 0 0 1.0416667 0.5774397 KISS1;CCL5
1141 regulation of striated muscle cell differentiation (GO:0051153) 1/85 0.5751779 1.0000000 0 0 1.1764706 0.6506774 HOPX
1142 regulation of anion transport (GO:0044070) 1/85 0.5751779 1.0000000 0 0 1.1764706 0.6506774 GRIK1
1143 blood vessel development (GO:0001568) 1/85 0.5751779 1.0000000 0 0 1.1764706 0.6506774 GPC3
1144 embryonic morphogenesis (GO:0048598) 4/403 0.5753961 1.0000000 0 0 0.9925558 0.5485822 GJA1;FGF9;GPC3;TBX4
1145 lipid transport (GO:0006869) 2/193 0.5772801 1.0000000 0 0 1.0362694 0.5693551 FABP3;PLA2G1B
1146 epidermal growth factor receptor signaling pathway (GO:0007173) 2/193 0.5772801 1.0000000 0 0 1.0362694 0.5693551 FGF9;FGF18
1147 long-chain fatty acid metabolic process (GO:0001676) 1/86 0.5794443 1.0000000 0 0 1.1627907 0.6345183 ALOX12
1148 regulation of stem cell proliferation (GO:0072091) 1/86 0.5794443 1.0000000 0 0 1.1627907 0.6345183 FGF9
1149 response to amino acid (GO:0043200) 1/86 0.5794443 1.0000000 0 0 1.1627907 0.6345183 ABCG2
1150 visual perception (GO:0007601) 2/195 0.5828991 1.0000000 0 0 1.0256410 0.5535806 OPN1SW;CNGA1
1151 positive regulation of cell projection organization (GO:0031346) 2/195 0.5828991 1.0000000 0 0 1.0256410 0.5535806 ROBO2;GPM6A
1152 feeding behavior (GO:0007631) 1/87 0.5836680 1.0000000 0 0 1.1494253 0.6188770 MC4R
1153 dicarboxylic acid metabolic process (GO:0043648) 1/87 0.5836680 1.0000000 0 0 1.1494253 0.6188770 QPRT
1154 negative regulation of proteolysis (GO:0045861) 3/302 0.5841348 1.0000000 0 0 0.9933775 0.5340631 PROS1;GPC3;A2ML1
1155 ERBB signaling pathway (GO:0038127) 2/196 0.5856881 1.0000000 0 0 1.0204082 0.5458856 FGF9;FGF18
1156 activation of cysteine-type endopeptidase activity (GO:0097202) 1/88 0.5878495 1.0000000 0 0 1.1363636 0.6037322 DLC1
1157 regulation of endothelial cell proliferation (GO:0001936) 1/88 0.5878495 1.0000000 0 0 1.1363636 0.6037322 FLT4
1158 adult locomotory behavior (GO:0008344) 1/88 0.5878495 1.0000000 0 0 1.1363636 0.6037322 SNCG
1159 regulation of cysteine-type endopeptidase activity (GO:2000116) 2/197 0.5884633 1.0000000 0 0 1.0152284 0.5383154 DLC1;ALOX12
1160 positive regulation of MAP kinase activity (GO:0043406) 2/197 0.5884633 1.0000000 0 0 1.0152284 0.5383154 PLA2G1B;DIRAS2
1161 lymphocyte activation (GO:0046649) 3/304 0.5886188 1.0000000 0 0 0.9868421 0.5230032 KLRK1;CD8B;CRTAM
1162 cellular response to organonitrogen compound (GO:0071417) 4/411 0.5909584 1.0000000 0 0 0.9732360 0.5119315 DDC;FGF9;PLA2G1B;FGF18
1163 T cell activation (GO:0042110) 2/198 0.5912248 1.0000000 0 0 1.0101010 0.5308676 CD8B;CRTAM
1164 energy derivation by oxidation of organic compounds (GO:0015980) 2/198 0.5912248 1.0000000 0 0 1.0101010 0.5308676 MC4R;LEPR
1165 sensory perception of light stimulus (GO:0050953) 2/198 0.5912248 1.0000000 0 0 1.0101010 0.5308676 OPN1SW;CNGA1
1166 RNA modification (GO:0009451) 1/89 0.5919892 1.0000000 0 0 1.1235955 0.5890639 APOBEC2
1167 leukocyte proliferation (GO:0070661) 1/89 0.5919892 1.0000000 0 0 1.1235955 0.5890639 CRTAM
1168 cellular response to tumor necrosis factor (GO:0071356) 1/89 0.5919892 1.0000000 0 0 1.1235955 0.5890639 CCL5
1169 cellular transition metal ion homeostasis (GO:0046916) 1/89 0.5919892 1.0000000 0 0 1.1235955 0.5890639 ABCG2
1170 cellular modified amino acid metabolic process (GO:0006575) 2/199 0.5939726 1.0000000 0 0 1.0050251 0.5235399 PLA2G1B;PADI3
1171 positive regulation of chemotaxis (GO:0050921) 1/90 0.5960875 1.0000000 0 0 1.1111111 0.5748531 CCL5
1172 regulation of glucose transport (GO:0010827) 1/90 0.5960875 1.0000000 0 0 1.1111111 0.5748531 GPC3
1173 water-soluble vitamin metabolic process (GO:0006767) 1/90 0.5960875 1.0000000 0 0 1.1111111 0.5748531 QPRT
1174 carboxylic acid catabolic process (GO:0046395) 2/200 0.5967066 1.0000000 0 0 1.0000000 0.5163298 ACOXL;QPRT
1175 organic acid catabolic process (GO:0016054) 2/200 0.5967066 1.0000000 0 0 1.0000000 0.5163298 ACOXL;QPRT
1176 protein processing (GO:0016485) 2/201 0.5994269 1.0000000 0 0 0.9950249 0.5092351 DLC1;SCG5
1177 positive regulation of hormone secretion (GO:0046887) 1/91 0.6001449 1.0000000 0 0 1.0989011 0.5610815 KISS1
1178 negative regulation of canonical Wnt signaling pathway (GO:0090090) 1/91 0.6001449 1.0000000 0 0 1.0989011 0.5610815 GPC3
1179 adaptive immune response (GO:0002250) 1/91 0.6001449 1.0000000 0 0 1.0989011 0.5610815 CRTAM
1180 negative regulation of kinase activity (GO:0033673) 2/202 0.6021334 1.0000000 0 0 0.9900990 0.5022537 CAMK2N1;DUSP26
1181 signal transduction by phosphorylation (GO:0023014) 2/202 0.6021334 1.0000000 0 0 0.9900990 0.5022537 DOK5;CCL5
1182 iron ion homeostasis (GO:0055072) 1/92 0.6041617 1.0000000 0 0 1.0869565 0.5477319 ABCG2
1183 interaction with host (GO:0051701) 1/92 0.6041617 1.0000000 0 0 1.0869565 0.5477319 IFIT1
1184 aging (GO:0007568) 2/204 0.6075053 1.0000000 0 0 0.9803922 0.4886220 DDC;ALOX12
1185 regulation of cytokine biosynthetic process (GO:0042035) 1/93 0.6081384 1.0000000 0 0 1.0752688 0.5347880 SFTPD
1186 hormone-mediated signaling pathway (GO:0009755) 1/93 0.6081384 1.0000000 0 0 1.0752688 0.5347880 OR51E2
1187 meiotic cell cycle process (GO:1903046) 1/93 0.6081384 1.0000000 0 0 1.0752688 0.5347880 MEIOB
1188 regulation of glucose metabolic process (GO:0010906) 1/94 0.6120753 1.0000000 0 0 1.0638298 0.5222340 LEPR
1189 multicellular organismal metabolic process (GO:0044236) 1/94 0.6120753 1.0000000 0 0 1.0638298 0.5222340 PLA2G1B
1190 negative regulation of protein processing (GO:0010955) 3/316 0.6148691 1.0000000 0 0 0.9493671 0.4617208 PROS1;GPC3;A2ML1
1191 negative regulation of protein maturation (GO:1903318) 3/316 0.6148691 1.0000000 0 0 0.9493671 0.4617208 PROS1;GPC3;A2ML1
1192 regulation of cytokine-mediated signaling pathway (GO:0001959) 1/95 0.6159728 1.0000000 0 0 1.0526316 0.5100552 CCL5
1193 negative regulation of binding (GO:0051100) 1/95 0.6159728 1.0000000 0 0 1.0526316 0.5100552 IFIT1
1194 establishment of vesicle localization (GO:0051650) 1/95 0.6159728 1.0000000 0 0 1.0526316 0.5100552 DDC
1195 anatomical structure homeostasis (GO:0060249) 2/208 0.6180843 1.0000000 0 0 0.9615385 0.4626254 SFTPD;KCNJ1
1196 lipid homeostasis (GO:0055088) 1/96 0.6198314 1.0000000 0 0 1.0416667 0.4982372 FABP3
1197 fat cell differentiation (GO:0045444) 1/96 0.6198314 1.0000000 0 0 1.0416667 0.4982372 RUNX1T1
1198 regulation of T cell differentiation (GO:0045580) 1/97 0.6236514 1.0000000 0 0 1.0309278 0.4867667 HLA-DOA
1199 regeneration (GO:0031099) 1/97 0.6236514 1.0000000 0 0 1.0309278 0.4867667 GJA1
1200 negative regulation of extrinsic apoptotic signaling pathway (GO:2001237) 1/97 0.6236514 1.0000000 0 0 1.0309278 0.4867667 CX3CR1
1201 nucleosome assembly (GO:0006334) 1/97 0.6236514 1.0000000 0 0 1.0309278 0.4867667 NAP1L3
1202 coenzyme biosynthetic process (GO:0009108) 1/98 0.6274332 1.0000000 0 0 1.0204082 0.4756306 QPRT
1203 glycosaminoglycan biosynthetic process (GO:0006024) 1/99 0.6311772 1.0000000 0 0 1.0101010 0.4648167 GPC3
1204 cellular response to hypoxia (GO:0071456) 1/99 0.6311772 1.0000000 0 0 1.0101010 0.4648167 KCNK3
1205 cellular response to metal ion (GO:0071248) 1/99 0.6311772 1.0000000 0 0 1.0101010 0.4648167 KCNK3
1206 positive regulation of sequence-specific DNA binding transcription factor activity (GO:0051091) 2/214 0.6335421 1.0000000 0 0 0.9345794 0.4265691 BEX1;PLA2G1B
1207 aminoglycan biosynthetic process (GO:0006023) 1/100 0.6348838 1.0000000 0 0 1.0000000 0.4543133 GPC3
1208 response to estradiol (GO:0032355) 1/100 0.6348838 1.0000000 0 0 1.0000000 0.4543133 RAMP2
1209 fertilization (GO:0009566) 1/100 0.6348838 1.0000000 0 0 1.0000000 0.4543133 MEIOB
1210 organophosphate biosynthetic process (GO:0090407) 4/436 0.6373809 1.0000000 0 0 0.9174312 0.4131999 NPPC;RAMP2;PLA2G1B;QPRT
1211 negative regulation of cytoskeleton organization (GO:0051494) 1/101 0.6385533 1.0000000 0 0 0.9900990 0.4441090 DLC1
1212 regulation of response to cytokine stimulus (GO:0060759) 1/101 0.6385533 1.0000000 0 0 0.9900990 0.4441090 CCL5
1213 protein import (GO:0017038) 1/101 0.6385533 1.0000000 0 0 0.9900990 0.4441090 FGF9
1214 cellular response to decreased oxygen levels (GO:0036294) 1/101 0.6385533 1.0000000 0 0 0.9900990 0.4441090 KCNK3
1215 protein localization to nucleus (GO:0034504) 1/101 0.6385533 1.0000000 0 0 0.9900990 0.4441090 FGF9
1216 cellular component morphogenesis (GO:0032989) 4/437 0.6391657 1.0000000 0 0 0.9153318 0.4096948 GPM6A;GJA1;DMRT1;DCX
1217 positive regulation of neuron differentiation (GO:0045666) 2/217 0.6410868 1.0000000 0 0 0.9216590 0.4097607 ROBO2;FEZF2
1218 organic hydroxy compound transport (GO:0015850) 1/102 0.6421861 1.0000000 0 0 0.9803922 0.4341933 SLC5A7
1219 DNA catabolic process (GO:0006308) 1/102 0.6421861 1.0000000 0 0 0.9803922 0.4341933 MEIOB
1220 regulation of phosphatase activity (GO:0010921) 1/102 0.6421861 1.0000000 0 0 0.9803922 0.4341933 SLC7A14
1221 carbohydrate transport (GO:0008643) 1/102 0.6421861 1.0000000 0 0 0.9803922 0.4341933 PLA2G1B
1222 zymogen activation (GO:0031638) 1/102 0.6421861 1.0000000 0 0 0.9803922 0.4341933 DLC1
1223 peptidyl-tyrosine dephosphorylation (GO:0035335) 1/102 0.6421861 1.0000000 0 0 0.9803922 0.4341933 DUSP26
1224 immune response-activating signal transduction (GO:0002757) 4/440 0.6444860 1.0000000 0 0 0.9090909 0.3993656 IGHG4;TRAC;SKAP1;HLA-DQB2
1225 positive regulation of mitotic cell cycle (GO:0045931) 1/103 0.6457826 1.0000000 0 0 0.9708738 0.4245557 DMRT1
1226 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains (GO:0002822) 1/103 0.6457826 1.0000000 0 0 0.9708738 0.4245557 HLA-DQB2
1227 positive regulation of lipid metabolic process (GO:0045834) 1/103 0.6457826 1.0000000 0 0 0.9708738 0.4245557 FABP3
1228 response to radiation (GO:0009314) 4/442 0.6480044 1.0000000 0 0 0.9049774 0.3926315 MFAP4;OPN1SW;GPC3;CNGA1
1229 antigen processing and presentation of peptide antigen via MHC class I (GO:0002474) 1/104 0.6493431 1.0000000 0 0 0.9615385 0.4151866 CD207
1230 alcohol biosynthetic process (GO:0046165) 1/104 0.6493431 1.0000000 0 0 0.9615385 0.4151866 CH25H
1231 response to ketone (GO:1901654) 1/105 0.6528680 1.0000000 0 0 0.9523810 0.4060766 RAMP2
1232 negative regulation of endopeptidase activity (GO:0010951) 2/222 0.6533903 1.0000000 0 0 0.9009009 0.3834060 PROS1;A2ML1
1233 protein maturation (GO:0051604) 2/222 0.6533903 1.0000000 0 0 0.9009009 0.3834060 DLC1;SCG5
1234 membrane depolarization (GO:0051899) 1/106 0.6563576 1.0000000 0 0 0.9433962 0.3972165 GRIK1
1235 cellular amino acid biosynthetic process (GO:0008652) 1/106 0.6563576 1.0000000 0 0 0.9433962 0.3972165 PADI3
1236 regulation of cytokine secretion (GO:0050707) 1/106 0.6563576 1.0000000 0 0 0.9433962 0.3972165 CRTAM
1237 regulation of osteoblast differentiation (GO:0045667) 1/106 0.6563576 1.0000000 0 0 0.9433962 0.3972165 NPPC
1238 hematopoietic progenitor cell differentiation (GO:0002244) 1/106 0.6563576 1.0000000 0 0 0.9433962 0.3972165 APOBEC3H
1239 epithelial cell development (GO:0002064) 1/107 0.6598123 1.0000000 0 0 0.9345794 0.3885980 DMRT1
1240 positive regulation of JNK cascade (GO:0046330) 1/107 0.6598123 1.0000000 0 0 0.9345794 0.3885980 FLT4
1241 positive regulation of cell growth (GO:0030307) 1/107 0.6598123 1.0000000 0 0 0.9345794 0.3885980 ALOX12
1242 steroid biosynthetic process (GO:0006694) 1/108 0.6632325 1.0000000 0 0 0.9259259 0.3802127 CH25H
1243 maintenance of protein location (GO:0045185) 1/108 0.6632325 1.0000000 0 0 0.9259259 0.3802127 FBN1
1244 regulation of epithelial cell differentiation (GO:0030856) 1/109 0.6666184 1.0000000 0 0 0.9174312 0.3720527 ALOX12
1245 regulation of Ras protein signal transduction (GO:0046578) 1/109 0.6666184 1.0000000 0 0 0.9174312 0.3720527 DLC1
1246 response to ethanol (GO:0045471) 1/109 0.6666184 1.0000000 0 0 0.9174312 0.3720527 NPPC
1247 cellular response to oxygen levels (GO:0071453) 1/109 0.6666184 1.0000000 0 0 0.9174312 0.3720527 KCNK3
1248 axonogenesis (GO:0007409) 1/109 0.6666184 1.0000000 0 0 0.9174312 0.3720527 DCX
1249 cellular process involved in reproduction in multicellular organism (GO:0022412) 2/228 0.6677106 1.0000000 0 0 0.8771930 0.3542987 ROBO2;DMRT1
1250 regulation of leukocyte migration (GO:0002685) 1/110 0.6699705 1.0000000 0 0 0.9090909 0.3641106 CCL5
1251 cellular response to inorganic substance (GO:0071241) 1/110 0.6699705 1.0000000 0 0 0.9090909 0.3641106 KCNK3
1252 regulation of hormone levels (GO:0010817) 2/229 0.6700506 1.0000000 0 0 0.8733624 0.3496962 MC4R;SCG5
1253 response to tumor necrosis factor (GO:0034612) 1/111 0.6732890 1.0000000 0 0 0.9009009 0.3563789 CCL5
1254 regulation of peptide transport (GO:0090087) 2/231 0.6746907 1.0000000 0 0 0.8658009 0.3406934 KISS1;CCL5
1255 negative regulation of phosphorus metabolic process (GO:0010563) 4/458 0.6753226 1.0000000 0 0 0.8733624 0.3428513 GABBR2;CAMK2N1;SLC7A14;DUSP26
1256 negative regulation of phosphate metabolic process (GO:0045936) 4/458 0.6753226 1.0000000 0 0 0.8733624 0.3428513 GABBR2;CAMK2N1;SLC7A14;DUSP26
1257 regulation of mitosis (GO:0007088) 1/112 0.6765743 1.0000000 0 0 0.8928571 0.3488508 DMRT1
1258 cell activation involved in immune response (GO:0002263) 1/112 0.6765743 1.0000000 0 0 0.8928571 0.3488508 CX3CR1
1259 leukocyte activation involved in immune response (GO:0002366) 1/112 0.6765743 1.0000000 0 0 0.8928571 0.3488508 CX3CR1
1260 regulation of adaptive immune response (GO:0002819) 1/112 0.6765743 1.0000000 0 0 0.8928571 0.3488508 HLA-DQB2
1261 gonad development (GO:0008406) 1/112 0.6765743 1.0000000 0 0 0.8928571 0.3488508 FGF9
1262 regulation of cell shape (GO:0008360) 1/112 0.6765743 1.0000000 0 0 0.8928571 0.3488508 DLC1
1263 lipid catabolic process (GO:0016042) 2/232 0.6769910 1.0000000 0 0 0.8620690 0.3362908 ACOXL;PLA2G1B
1264 exocytosis (GO:0006887) 2/233 0.6792781 1.0000000 0 0 0.8583691 0.3319525 PROS1;CCL5
1265 peptide metabolic process (GO:0006518) 1/113 0.6798268 1.0000000 0 0 0.8849558 0.3415197 SCG5
1266 regulation of lipid biosynthetic process (GO:0046890) 1/113 0.6798268 1.0000000 0 0 0.8849558 0.3415197 FABP3
1267 protein-DNA complex assembly (GO:0065004) 1/113 0.6798268 1.0000000 0 0 0.8849558 0.3415197 NAP1L3
1268 regulation of cell division (GO:0051302) 2/234 0.6815520 1.0000000 0 0 0.8547009 0.3276775 DMRT1;FGF9
1269 double-strand break repair (GO:0006302) 1/114 0.6830467 1.0000000 0 0 0.8771930 0.3343790 MEIOB
1270 tube formation (GO:0035148) 1/114 0.6830467 1.0000000 0 0 0.8771930 0.3343790 DLC1
1271 regulation of axonogenesis (GO:0050770) 1/114 0.6830467 1.0000000 0 0 0.8771930 0.3343790 ROBO2
1272 positive regulation of lymphocyte proliferation (GO:0050671) 1/115 0.6862344 1.0000000 0 0 0.8695652 0.3274226 CCL5
1273 Fc receptor signaling pathway (GO:0038093) 3/352 0.6867026 1.0000000 0 0 0.8522727 0.3203301 IGHG4;FGF9;FGF18
1274 negative regulation of organelle organization (GO:0010639) 2/237 0.6882952 1.0000000 0 0 0.8438819 0.3152215 DMRT1;DLC1
1275 extracellular matrix disassembly (GO:0022617) 1/116 0.6893902 1.0000000 0 0 0.8620690 0.3206447 FBN1
1276 positive regulation of mononuclear cell proliferation (GO:0032946) 1/116 0.6893902 1.0000000 0 0 0.8620690 0.3206447 CCL5
1277 response to UV (GO:0009411) 1/117 0.6925144 1.0000000 0 0 0.8547009 0.3140395 MFAP4
1278 steroid metabolic process (GO:0008202) 2/240 0.6949213 1.0000000 0 0 0.8333333 0.3032972 CH25H;LEPR
1279 positive regulation of stress-activated MAPK cascade (GO:0032874) 1/118 0.6956073 1.0000000 0 0 0.8474576 0.3076017 FLT4
1280 regulation of DNA replication (GO:0006275) 1/118 0.6956073 1.0000000 0 0 0.8474576 0.3076017 PLA2G1B
1281 cell maturation (GO:0048469) 1/118 0.6956073 1.0000000 0 0 0.8474576 0.3076017 GJA1
1282 embryonic organ development (GO:0048568) 1/119 0.6986693 1.0000000 0 0 0.8403361 0.3013258 FGF9
1283 positive regulation of leukocyte proliferation (GO:0070665) 1/119 0.6986693 1.0000000 0 0 0.8403361 0.3013258 CCL5
1284 positive regulation of stress-activated protein kinase signaling cascade (GO:0070304) 1/119 0.6986693 1.0000000 0 0 0.8403361 0.3013258 FLT4
1285 epidermis development (GO:0008544) 1/120 0.7017006 1.0000000 0 0 0.8333333 0.2952070 EMP1
1286 nucleosome organization (GO:0034728) 1/120 0.7017006 1.0000000 0 0 0.8333333 0.2952070 NAP1L3
1287 regulation of cell projection assembly (GO:0060491) 1/120 0.7017006 1.0000000 0 0 0.8333333 0.2952070 GPM6A
1288 transition metal ion homeostasis (GO:0055076) 1/120 0.7017006 1.0000000 0 0 0.8333333 0.2952070 ABCG2
1289 negative regulation of defense response (GO:0031348) 1/120 0.7017006 1.0000000 0 0 0.8333333 0.2952070 IFIT1
1290 plasma membrane organization (GO:0007009) 1/121 0.7047016 1.0000000 0 0 0.8264463 0.2892403 RAMP2
1291 neuron development (GO:0048666) 1/121 0.7047016 1.0000000 0 0 0.8264463 0.2892403 ROBO2
1292 germ cell development (GO:0007281) 1/121 0.7047016 1.0000000 0 0 0.8264463 0.2892403 DMRT1
1293 response to temperature stimulus (GO:0009266) 1/122 0.7076726 1.0000000 0 0 0.8196721 0.2834211 STAC
1294 adenylate cyclase-modulating G-protein coupled receptor signaling pathway (GO:0007188) 1/122 0.7076726 1.0000000 0 0 0.8196721 0.2834211 MC4R
1295 regulation of gene expression, epigenetic (GO:0040029) 1/122 0.7076726 1.0000000 0 0 0.8196721 0.2834211 APOBEC2
1296 vitamin metabolic process (GO:0006766) 1/122 0.7076726 1.0000000 0 0 0.8196721 0.2834211 QPRT
1297 regulation of muscle cell differentiation (GO:0051147) 1/122 0.7076726 1.0000000 0 0 0.8196721 0.2834211 HOPX
1298 regionalization (GO:0003002) 2/247 0.7099322 1.0000000 0 0 0.8097166 0.2773974 HHIP;FEZF2
1299 cellular response to steroid hormone stimulus (GO:0071383) 1/123 0.7106138 1.0000000 0 0 0.8130081 0.2777449 OR51E2
1300 ameboidal-type cell migration (GO:0001667) 1/123 0.7106138 1.0000000 0 0 0.8130081 0.2777449 GPR124
1301 positive regulation of cell morphogenesis involved in differentiation (GO:0010770) 1/123 0.7106138 1.0000000 0 0 0.8130081 0.2777449 ROBO2
1302 regulation of lymphocyte differentiation (GO:0045619) 1/124 0.7135255 1.0000000 0 0 0.8064516 0.2722073 HLA-DOA
1303 mucopolysaccharide metabolic process (GO:1903510) 1/124 0.7135255 1.0000000 0 0 0.8064516 0.2722073 GPC3
1304 positive regulation of DNA metabolic process (GO:0051054) 1/124 0.7135255 1.0000000 0 0 0.8064516 0.2722073 PLA2G1B
1305 neuron projection guidance (GO:0097485) 3/367 0.7135377 1.0000000 0 0 0.8174387 0.2759019 ROBO2;DCX;FEZF2
1306 axon guidance (GO:0007411) 3/367 0.7135377 1.0000000 0 0 0.8174387 0.2759019 ROBO2;DCX;FEZF2
1307 phosphatidylinositol metabolic process (GO:0046488) 1/125 0.7164081 1.0000000 0 0 0.8000000 0.2668042 PLA2G1B
1308 positive regulation of NF-kappaB transcription factor activity (GO:0051092) 1/126 0.7192619 1.0000000 0 0 0.7936508 0.2615316 PLA2G1B
1309 activation of immune response (GO:0002253) 4/487 0.7210317 1.0000000 0 0 0.8213552 0.2686424 IGHG4;TRAC;SKAP1;HLA-DQB2
1310 circadian rhythm (GO:0007623) 1/127 0.7220870 1.0000000 0 0 0.7874016 0.2563855 DDC
1311 cofactor biosynthetic process (GO:0051188) 1/127 0.7220870 1.0000000 0 0 0.7874016 0.2563855 QPRT
1312 actin cytoskeleton organization (GO:0030036) 2/253 0.7223054 1.0000000 0 0 0.7905138 0.2571598 DLC1;MYOZ1
1313 calcium ion transmembrane transport (GO:0070588) 1/128 0.7248839 1.0000000 0 0 0.7812500 0.2513623 GPM6A
1314 response to metal ion (GO:0010038) 2/255 0.7263303 1.0000000 0 0 0.7843137 0.2507846 KCNK3;ABCG2
1315 generation of precursor metabolites and energy (GO:0006091) 3/375 0.7271132 1.0000000 0 0 0.8000000 0.2549385 MC4R;LEPR;RUNX1T1
1316 inflammatory response (GO:0006954) 3/376 0.7287745 1.0000000 0 0 0.7978723 0.2524396 GJA1;SCUBE1;CCL5
1317 positive regulation of protein serine/threonine kinase activity (GO:0071902) 2/257 0.7303060 1.0000000 0 0 0.7782101 0.2445850 PLA2G1B;DIRAS2
1318 positive regulation of response to wounding (GO:1903036) 1/130 0.7303939 1.0000000 0 0 0.7692308 0.2416702 HOPX
1319 negative regulation of MAPK cascade (GO:0043409) 1/130 0.7303939 1.0000000 0 0 0.7692308 0.2416702 DUSP26
1320 carbohydrate derivative biosynthetic process (GO:1901137) 3/377 0.7304279 1.0000000 0 0 0.7957560 0.2499667 NPPC;RAMP2;GPC3
1321 cellular lipid catabolic process (GO:0044242) 1/131 0.7331076 1.0000000 0 0 0.7633588 0.2369945 ACOXL
1322 regulation of protein transport (GO:0051223) 3/379 0.7337111 1.0000000 0 0 0.7915567 0.2450976 PLA2G1B;CRTAM;OR51E2
1323 signal transduction by p53 class mediator (GO:0072331) 1/132 0.7357941 1.0000000 0 0 0.7575758 0.2324280 ZNF385B
1324 negative regulation of protein phosphorylation (GO:0001933) 2/260 0.7361780 1.0000000 0 0 0.7692308 0.2356026 CAMK2N1;DUSP26
1325 regulation of protein catabolic process (GO:0042176) 2/260 0.7361780 1.0000000 0 0 0.7692308 0.2356026 GJA1;GPC3
1326 small molecule catabolic process (GO:0044282) 2/261 0.7381112 1.0000000 0 0 0.7662835 0.2326903 ACOXL;QPRT
1327 activation of MAPK activity (GO:0000187) 1/133 0.7384537 1.0000000 0 0 0.7518797 0.2279676 PLA2G1B
1328 humoral immune response (GO:0006959) 2/263 0.7419414 1.0000000 0 0 0.7604563 0.2269848 IGHG4;PLA2G1B
1329 pattern specification process (GO:0007389) 3/385 0.7433729 1.0000000 0 0 0.7792208 0.2310837 HHIP;GPC3;FEZF2
1330 reproductive structure development (GO:0048608) 2/265 0.7457238 1.0000000 0 0 0.7547170 0.2214339 FGF9;PEG10
1331 protein-DNA complex subunit organization (GO:0071824) 1/136 0.7462737 1.0000000 0 0 0.7352941 0.2151933 NAP1L3
1332 regulation of cellular carbohydrate metabolic process (GO:0010675) 1/137 0.7488283 1.0000000 0 0 0.7299270 0.2111281 LEPR
1333 neuron projection development (GO:0031175) 1/137 0.7488283 1.0000000 0 0 0.7299270 0.2111281 FEZF2
1334 regulation of ion transmembrane transporter activity (GO:0032412) 1/137 0.7488283 1.0000000 0 0 0.7299270 0.2111281 KCNJ1
1335 regulation of nuclear division (GO:0051783) 1/138 0.7513574 1.0000000 0 0 0.7246377 0.2071550 DMRT1
1336 positive regulation of peptidyl-tyrosine phosphorylation (GO:0050731) 1/139 0.7538610 1.0000000 0 0 0.7194245 0.2032714 CCL5
1337 regulation of heart contraction (GO:0008016) 1/140 0.7563396 1.0000000 0 0 0.7142857 0.1994748 HOPX
1338 regulation of transmembrane transporter activity (GO:0022898) 1/141 0.7587934 1.0000000 0 0 0.7092199 0.1957629 KCNJ1
1339 response to reactive oxygen species (GO:0000302) 1/141 0.7587934 1.0000000 0 0 0.7092199 0.1957629 SCGB1A1
1340 regulation of MAP kinase activity (GO:0043405) 2/273 0.7603837 1.0000000 0 0 0.7326007 0.2006829 PLA2G1B;DIRAS2
1341 response to alcohol (GO:0097305) 2/274 0.7621641 1.0000000 0 0 0.7299270 0.1982434 NPPC;RAMP2
1342 neurotrophin TRK receptor signaling pathway (GO:0048011) 2/274 0.7621641 1.0000000 0 0 0.7299270 0.1982434 FGF9;FGF18
1343 positive regulation of neuron projection development (GO:0010976) 1/144 0.7660082 1.0000000 0 0 0.6944444 0.1851128 ROBO2
1344 regulation of carbohydrate metabolic process (GO:0006109) 1/145 0.7683650 1.0000000 0 0 0.6896552 0.1817175 LEPR
1345 neurotrophin signaling pathway (GO:0038179) 2/278 0.7691720 1.0000000 0 0 0.7194245 0.1888062 FGF9;FGF18
1346 organ morphogenesis (GO:0009887) 3/405 0.7735836 1.0000000 0 0 0.7407407 0.1901641 HHIP;DLC1;TBX4
1347 regulation of JNK cascade (GO:0046328) 1/148 0.7752949 1.0000000 0 0 0.6756757 0.1719675 FLT4
1348 positive regulation of Rho GTPase activity (GO:0032321) 1/149 0.7775586 1.0000000 0 0 0.6711409 0.1688565 DLC1
1349 positive regulation of neurogenesis (GO:0050769) 2/283 0.7776798 1.0000000 0 0 0.7067138 0.1776964 ROBO2;FEZF2
1350 negative regulation of transferase activity (GO:0051348) 2/284 0.7793483 1.0000000 0 0 0.7042254 0.1755614 CAMK2N1;DUSP26
1351 actin filament organization (GO:0007015) 1/150 0.7797997 1.0000000 0 0 0.6666667 0.1658121 PLA2G1B
1352 anterior/posterior pattern specification (GO:0009952) 1/150 0.7797997 1.0000000 0 0 0.6666667 0.1658121 FEZF2
1353 negative regulation of cell growth (GO:0030308) 1/150 0.7797997 1.0000000 0 0 0.6666667 0.1658121 SCGB3A1
1354 peptidyl-tyrosine phosphorylation (GO:0018108) 1/152 0.7842147 1.0000000 0 0 0.6578947 0.1599160 FLT4
1355 maintenance of location (GO:0051235) 1/152 0.7842147 1.0000000 0 0 0.6578947 0.1599160 FBN1
1356 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger (GO:0007187) 1/153 0.7863891 1.0000000 0 0 0.6535948 0.1570612 MC4R
1357 regulation of transporter activity (GO:0032409) 1/153 0.7863891 1.0000000 0 0 0.6535948 0.1570612 KCNJ1
1358 myeloid cell differentiation (GO:0030099) 1/154 0.7885417 1.0000000 0 0 0.6493506 0.1542663 GPC3
1359 developmental maturation (GO:0021700) 1/154 0.7885417 1.0000000 0 0 0.6493506 0.1542663 GJA1
1360 peptidyl-tyrosine modification (GO:0018212) 1/154 0.7885417 1.0000000 0 0 0.6493506 0.1542663 FLT4
1361 cellular amino acid metabolic process (GO:0006520) 3/421 0.7956155 1.0000000 0 0 0.7125891 0.1629258 DDC;PLA2G1B;PADI3
1362 hormone metabolic process (GO:0042445) 1/158 0.7969382 1.0000000 0 0 0.6329114 0.1436570 SCG5
1363 Fc-epsilon receptor signaling pathway (GO:0038095) 2/295 0.7969918 1.0000000 0 0 0.6779661 0.1538379 FGF9;FGF18
1364 regulation of extrinsic apoptotic signaling pathway (GO:2001236) 1/161 0.8030171 1.0000000 0 0 0.6211180 0.1362604 CX3CR1
1365 protein dephosphorylation (GO:0006470) 1/161 0.8030171 1.0000000 0 0 0.6211180 0.1362604 DUSP26
1366 complement activation, classical pathway (GO:0006958) 1/162 0.8050029 1.0000000 0 0 0.6172840 0.1338947 IGHG4
1367 glycosaminoglycan metabolic process (GO:0030203) 1/162 0.8050029 1.0000000 0 0 0.6172840 0.1338947 GPC3
1368 response to nutrient (GO:0007584) 1/163 0.8069688 1.0000000 0 0 0.6134969 0.1315768 ABCG2
1369 actin filament-based process (GO:0030029) 2/303 0.8090320 1.0000000 0 0 0.6600660 0.1398791 DLC1;MYOZ1
1370 cellular response to transforming growth factor beta stimulus (GO:0071560) 1/166 0.8127489 1.0000000 0 0 0.6024096 0.1248994 CX3CR1
1371 response to estrogen (GO:0043627) 1/166 0.8127489 1.0000000 0 0 0.6024096 0.1248994 RAMP2
1372 response to transforming growth factor beta (GO:0071559) 1/166 0.8127489 1.0000000 0 0 0.6024096 0.1248994 CX3CR1
1373 regulation of vesicle-mediated transport (GO:0060627) 2/306 0.8133814 1.0000000 0 0 0.6535948 0.1350034 SFTPD;GPC3
1374 response to wounding (GO:0009611) 1/167 0.8146371 1.0000000 0 0 0.5988024 0.1227620 CX3CR1
1375 establishment of organelle localization (GO:0051656) 1/168 0.8165063 1.0000000 0 0 0.5952381 0.1206671 DDC
1376 positive regulation of I-kappaB kinase/NF-kappaB signaling (GO:0043123) 1/168 0.8165063 1.0000000 0 0 0.5952381 0.1206671 GJA1
1377 regulation of insulin secretion (GO:0050796) 1/169 0.8183568 1.0000000 0 0 0.5917160 0.1186135 CCL5
1378 regulation of stress-activated MAPK cascade (GO:0032872) 1/170 0.8201887 1.0000000 0 0 0.5882353 0.1166005 FLT4
1379 protein autophosphorylation (GO:0046777) 1/170 0.8201887 1.0000000 0 0 0.5882353 0.1166005 FLT4
1380 intrinsic apoptotic signaling pathway (GO:0097193) 1/170 0.8201887 1.0000000 0 0 0.5882353 0.1166005 ZNF385B
1381 regulation of establishment of protein localization (GO:0070201) 3/442 0.8218049 1.0000000 0 0 0.6787330 0.1332029 PLA2G1B;CRTAM;OR51E2
1382 aminoglycan metabolic process (GO:0006022) 1/171 0.8220022 1.0000000 0 0 0.5847953 0.1146270 GPC3
1383 regulation of stress-activated protein kinase signaling cascade (GO:0070302) 1/171 0.8220022 1.0000000 0 0 0.5847953 0.1146270 FLT4
1384 positive regulation of nervous system development (GO:0051962) 2/313 0.8231892 1.0000000 0 0 0.6389776 0.1243253 ROBO2;FEZF2
1385 regulation of Rho GTPase activity (GO:0032319) 1/174 0.8273342 1.0000000 0 0 0.5747126 0.1089348 DLC1
1386 complement activation (GO:0006956) 1/175 0.8290760 1.0000000 0 0 0.5714286 0.1071105 IGHG4
1387 response to mechanical stimulus (GO:0009612) 1/176 0.8308003 1.0000000 0 0 0.5681818 0.1053215 GJA1
1388 cellular amide metabolic process (GO:0043603) 1/177 0.8325073 1.0000000 0 0 0.5649718 0.1035668 SCG5
1389 glycerophospholipid biosynthetic process (GO:0046474) 1/178 0.8341972 1.0000000 0 0 0.5617978 0.1018458 PLA2G1B
1390 regulation of cell growth (GO:0001558) 2/322 0.8351215 1.0000000 0 0 0.6211180 0.1119119 SCGB3A1;ALOX12
1391 nucleobase-containing compound transport (GO:0015931) 1/180 0.8375262 1.0000000 0 0 0.5555556 0.0985015 GJA1
1392 positive regulation of protein kinase activity (GO:0045860) 3/456 0.8376406 1.0000000 0 0 0.6578947 0.1165566 PLA2G1B;CCL5;DIRAS2
1393 negative regulation of phosphorylation (GO:0042326) 2/325 0.8389352 1.0000000 0 0 0.6153846 0.1080750 CAMK2N1;DUSP26
1394 ATP catabolic process (GO:0006200) 2/327 0.8414333 1.0000000 0 0 0.6116208 0.1055954 KIF12;ABCG2
1395 positive regulation of cytokine production (GO:0001819) 2/327 0.8414333 1.0000000 0 0 0.6116208 0.1055954 FLT4;CRTAM
1396 cellular response to external stimulus (GO:0071496) 1/185 0.8455606 1.0000000 0 0 0.5405405 0.0906786 GJA1
1397 cellular component assembly involved in morphogenesis (GO:0010927) 1/186 0.8471194 1.0000000 0 0 0.5376344 0.0892009 MYOZ1
1398 ribonucleoside monophosphate catabolic process (GO:0009158) 2/332 0.8475264 1.0000000 0 0 0.6024096 0.0996586 KIF12;ABCG2
1399 purine ribonucleoside monophosphate catabolic process (GO:0009169) 2/332 0.8475264 1.0000000 0 0 0.6024096 0.0996586 KIF12;ABCG2
1400 microtubule-based movement (GO:0007018) 1/187 0.8486625 1.0000000 0 0 0.5347594 0.0877506 KIF12
1401 negative regulation of apoptotic signaling pathway (GO:2001234) 1/187 0.8486625 1.0000000 0 0 0.5347594 0.0877506 CX3CR1
1402 purine nucleoside monophosphate catabolic process (GO:0009128) 2/333 0.8487194 1.0000000 0 0 0.6006006 0.0985145 KIF12;ABCG2
1403 nucleoside monophosphate catabolic process (GO:0009125) 2/335 0.8510799 1.0000000 0 0 0.5970149 0.0962682 KIF12;ABCG2
1404 regulation of peptidyl-tyrosine phosphorylation (GO:0050730) 1/189 0.8517025 1.0000000 0 0 0.5291005 0.0849302 CCL5
1405 coagulation (GO:0050817) 3/472 0.8542469 1.0000000 0 0 0.6355932 0.1001282 SCUBE1;PROS1;JAM2
1406 blood coagulation (GO:0007596) 3/472 0.8542469 1.0000000 0 0 0.6355932 0.1001282 SCUBE1;PROS1;JAM2
1407 regulation of sequence-specific DNA binding transcription factor activity (GO:0051090) 2/338 0.8545582 1.0000000 0 0 0.5917160 0.0930004 BEX1;PLA2G1B
1408 negative regulation of cellular component organization (GO:0051129) 3/474 0.8562155 1.0000000 0 0 0.6329114 0.0982488 ROBO2;DMRT1;DLC1
1409 hemostasis (GO:0007599) 3/478 0.8600836 1.0000000 0 0 0.6276151 0.0945977 SCUBE1;PROS1;JAM2
1410 muscle contraction (GO:0006936) 1/195 0.8604625 1.0000000 0 0 0.5128205 0.0770693 GJA1
1411 DNA recombination (GO:0006310) 1/196 0.8618716 1.0000000 0 0 0.5102041 0.0758413 MEIOB
1412 protein activation cascade (GO:0072376) 1/196 0.8618716 1.0000000 0 0 0.5102041 0.0758413 IGHG4
1413 coenzyme metabolic process (GO:0006732) 1/196 0.8618716 1.0000000 0 0 0.5102041 0.0758413 QPRT
1414 positive regulation of kinase activity (GO:0033674) 3/480 0.8619834 1.0000000 0 0 0.6250000 0.0928245 PLA2G1B;CCL5;DIRAS2
1415 negative regulation of intracellular signal transduction (GO:1902532) 2/345 0.8623889 1.0000000 0 0 0.5797101 0.0858254 DLC1;DUSP26
1416 positive regulation of response to external stimulus (GO:0032103) 1/201 0.8687075 1.0000000 0 0 0.4975124 0.0700243 CCL5
1417 glycerolipid biosynthetic process (GO:0045017) 1/202 0.8700337 1.0000000 0 0 0.4950495 0.0689224 PLA2G1B
1418 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis (GO:0002433) 1/203 0.8713466 1.0000000 0 0 0.4926108 0.0678401 IGHG4
1419 Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096) 1/203 0.8713466 1.0000000 0 0 0.4926108 0.0678401 IGHG4
1420 Fc-gamma receptor signaling pathway (GO:0038094) 1/203 0.8713466 1.0000000 0 0 0.4926108 0.0678401 IGHG4
1421 lipid biosynthetic process (GO:0008610) 3/491 0.8720349 1.0000000 0 0 0.6109980 0.0836614 CH25H;PLA2G1B;ALOX12
1422 cell morphogenesis (GO:0000902) 1/204 0.8726464 1.0000000 0 0 0.4901961 0.0667769 DMRT1
1423 nucleocytoplasmic transport (GO:0006913) 1/204 0.8726464 1.0000000 0 0 0.4901961 0.0667769 FGF9
1424 Fc receptor mediated stimulatory signaling pathway (GO:0002431) 1/204 0.8726464 1.0000000 0 0 0.4901961 0.0667769 IGHG4
1425 chromosome organization (GO:0051276) 1/204 0.8726464 1.0000000 0 0 0.4901961 0.0667769 MEIOB
1426 platelet activation (GO:0030168) 1/205 0.8739330 1.0000000 0 0 0.4878049 0.0657325 PROS1
1427 phospholipid biosynthetic process (GO:0008654) 1/206 0.8752067 1.0000000 0 0 0.4854369 0.0647064 PLA2G1B
1428 positive regulation of cell development (GO:0010720) 2/358 0.8759198 1.0000000 0 0 0.5586592 0.0740116 ROBO2;FEZF2
1429 nuclear transport (GO:0051169) 1/209 0.8789515 1.0000000 0 0 0.4784689 0.0617347 FGF9
1430 single-organism behavior (GO:0044708) 2/362 0.8798311 1.0000000 0 0 0.5524862 0.0707322 SNCG;GRIK1
1431 regulation of leukocyte differentiation (GO:1902105) 1/210 0.8801748 1.0000000 0 0 0.4761905 0.0607785 HLA-DOA
1432 post-translational protein modification (GO:0043687) 1/211 0.8813857 1.0000000 0 0 0.4739336 0.0598388 PROS1
1433 negative regulation of nervous system development (GO:0051961) 1/211 0.8813857 1.0000000 0 0 0.4739336 0.0598388 ROBO2
1434 regulation of I-kappaB kinase/NF-kappaB signaling (GO:0043122) 1/213 0.8837712 1.0000000 0 0 0.4694836 0.0580080 GJA1
1435 alpha-amino acid metabolic process (GO:1901605) 1/213 0.8837712 1.0000000 0 0 0.4694836 0.0580080 PADI3
1436 positive regulation of intracellular transport (GO:0032388) 1/217 0.8883999 1.0000000 0 0 0.4608295 0.0545315 PLA2G1B
1437 positive regulation of cell cycle process (GO:0090068) 1/220 0.8917506 1.0000000 0 0 0.4545455 0.0520767 DMRT1
1438 ATP metabolic process (GO:0046034) 2/377 0.8935096 1.0000000 0 0 0.5305040 0.0597338 KIF12;ABCG2
1439 in utero embryonic development (GO:0001701) 1/222 0.8939287 1.0000000 0 0 0.4504505 0.0505087 GJA1
1440 regulation of neuron death (GO:1901214) 1/225 0.8971142 1.0000000 0 0 0.4444444 0.0482543 CCL5
1441 chordate embryonic development (GO:0043009) 1/226 0.8981547 1.0000000 0 0 0.4424779 0.0475278 GJA1
1442 cognition (GO:0050890) 1/227 0.8991848 1.0000000 0 0 0.4405286 0.0468135 TMPRSS11E
1443 glycerophospholipid metabolic process (GO:0006650) 1/229 0.9012140 1.0000000 0 0 0.4366812 0.0454203 PLA2G1B
1444 embryo development ending in birth or egg hatching (GO:0009792) 1/230 0.9022132 1.0000000 0 0 0.4347826 0.0447410 GJA1
1445 nucleic acid phosphodiester bond hydrolysis (GO:0090305) 1/230 0.9022132 1.0000000 0 0 0.4347826 0.0447410 MEIOB
1446 regulation of anatomical structure size (GO:0090066) 1/232 0.9041817 1.0000000 0 0 0.4310345 0.0434159 NPPC
1447 regulation of cell projection organization (GO:0031344) 2/391 0.9049630 1.0000000 0 0 0.5115090 0.0510799 ROBO2;GPM6A
1448 muscle system process (GO:0003012) 1/237 0.9089322 1.0000000 0 0 0.4219409 0.0402890 GJA1
1449 negative regulation of cell development (GO:0010721) 1/239 0.9107660 1.0000000 0 0 0.4184100 0.0391085 NPPC
1450 regulation of actin cytoskeleton organization (GO:0032956) 1/240 0.9116691 1.0000000 0 0 0.4166667 0.0385326 DLC1
1451 purine ribonucleoside monophosphate metabolic process (GO:0009167) 2/402 0.9131472 1.0000000 0 0 0.4975124 0.0452031 KIF12;ABCG2
1452 purine nucleoside monophosphate metabolic process (GO:0009126) 2/403 0.9138576 1.0000000 0 0 0.4962779 0.0447050 KIF12;ABCG2
1453 GTP catabolic process (GO:0006184) 1/243 0.9143243 1.0000000 0 0 0.4115226 0.0368601 DIRAS2
1454 regulation of neuron differentiation (GO:0045664) 2/405 0.9152623 1.0000000 0 0 0.4938272 0.0437257 ROBO2;FEZF2
1455 regulation of lipid metabolic process (GO:0019216) 1/245 0.9160501 1.0000000 0 0 0.4081633 0.0357895 FABP3
1456 negative regulation of protein modification process (GO:0031400) 2/407 0.9166456 1.0000000 0 0 0.4914005 0.0427687 CAMK2N1;DUSP26
1457 guanosine-containing compound catabolic process (GO:1901069) 1/246 0.9169000 1.0000000 0 0 0.4065041 0.0352670 DIRAS2
1458 regulation of cell morphogenesis (GO:0022604) 2/408 0.9173293 1.0000000 0 0 0.4901961 0.0422984 ROBO2;DLC1
1459 regulation of cell morphogenesis involved in differentiation (GO:0010769) 1/248 0.9185742 1.0000000 0 0 0.4032258 0.0342470 ROBO2
1460 positive regulation of cellular component biogenesis (GO:0044089) 1/249 0.9193986 1.0000000 0 0 0.4016064 0.0337492 GPM6A
1461 leukocyte differentiation (GO:0002521) 1/251 0.9210227 1.0000000 0 0 0.3984064 0.0327771 GPC3
1462 activation of protein kinase activity (GO:0032147) 1/252 0.9218225 1.0000000 0 0 0.3968254 0.0323026 PLA2G1B
1463 ribonucleoside monophosphate metabolic process (GO:0009161) 2/416 0.9226129 1.0000000 0 0 0.4807692 0.0387238 KIF12;ABCG2
1464 regulation of protein serine/threonine kinase activity (GO:0071900) 2/416 0.9226129 1.0000000 0 0 0.4807692 0.0387238 PLA2G1B;DIRAS2
1465 negative regulation of cell cycle process (GO:0010948) 1/254 0.9233980 1.0000000 0 0 0.3937008 0.0313760 DMRT1
1466 cofactor metabolic process (GO:0051186) 1/255 0.9241738 1.0000000 0 0 0.3921569 0.0309236 QPRT
1467 cellular protein complex assembly (GO:0043623) 1/256 0.9249419 1.0000000 0 0 0.3906250 0.0304783 CCL5
1468 regulation of small GTPase mediated signal transduction (GO:0051056) 1/256 0.9249419 1.0000000 0 0 0.3906250 0.0304783 DLC1
1469 regulation of actin filament-based process (GO:0032970) 1/257 0.9257022 1.0000000 0 0 0.3891051 0.0300400 DLC1
1470 GTP metabolic process (GO:0046039) 1/258 0.9264548 1.0000000 0 0 0.3875969 0.0296085 DIRAS2
1471 nucleoside monophosphate metabolic process (GO:0009123) 2/427 0.9293624 1.0000000 0 0 0.4683841 0.0343122 KIF12;ABCG2
1472 regulation of translation (GO:0006417) 1/264 0.9308139 1.0000000 0 0 0.3787879 0.0271575 CCL5
1473 protein glycosylation (GO:0006486) 1/264 0.9308139 1.0000000 0 0 0.3787879 0.0271575 ST6GAL2
1474 macromolecule glycosylation (GO:0043413) 1/264 0.9308139 1.0000000 0 0 0.3787879 0.0271575 ST6GAL2
1475 negative regulation of cell cycle (GO:0045786) 2/430 0.9311049 1.0000000 0 0 0.4651163 0.0332016 NPPC;DMRT1
1476 guanosine-containing compound metabolic process (GO:1901068) 1/269 0.9342494 1.0000000 0 0 0.3717472 0.0252832 DIRAS2
1477 posttranscriptional regulation of gene expression (GO:0010608) 2/438 0.9355556 1.0000000 0 0 0.4566210 0.0304177 CCL5;SCGB1A1
1478 small GTPase mediated signal transduction (GO:0007264) 2/439 0.9360924 1.0000000 0 0 0.4555809 0.0300870 DLC1;DIRAS2
1479 glycosylation (GO:0070085) 1/273 0.9368751 1.0000000 0 0 0.3663004 0.0238847 ST6GAL2
1480 regulation of neuron projection development (GO:0010975) 1/275 0.9381486 1.0000000 0 0 0.3636364 0.0232171 ROBO2
1481 embryo development (GO:0009790) 1/276 0.9387757 1.0000000 0 0 0.3623188 0.0228908 GJA1
1482 protein localization to membrane (GO:0072657) 1/276 0.9387757 1.0000000 0 0 0.3623188 0.0228908 RAMP2
1483 organelle assembly (GO:0070925) 1/278 0.9400110 1.0000000 0 0 0.3597122 0.0222531 MYOZ1
1484 positive regulation of cell cycle (GO:0045787) 1/278 0.9400110 1.0000000 0 0 0.3597122 0.0222531 DMRT1
1485 dephosphorylation (GO:0016311) 1/278 0.9400110 1.0000000 0 0 0.3597122 0.0222531 DUSP26
1486 sensory perception (GO:0007600) 2/457 0.9450631 1.0000000 0 0 0.4376368 0.0247281 OPN1SW;CNGA1
1487 phospholipid metabolic process (GO:0006644) 1/288 0.9458253 1.0000000 0 0 0.3472222 0.0193394 PLA2G1B
1488 response to oxidative stress (GO:0006979) 1/290 0.9469190 1.0000000 0 0 0.3448276 0.0188075 SCGB1A1
1489 response to nutrient levels (GO:0031667) 1/291 0.9474576 1.0000000 0 0 0.3436426 0.0185474 ABCG2
1490 establishment of protein localization to organelle (GO:0072594) 1/292 0.9479908 1.0000000 0 0 0.3424658 0.0182913 FGF9
1491 positive regulation of Ras GTPase activity (GO:0032320) 1/292 0.9479908 1.0000000 0 0 0.3424658 0.0182913 DLC1
1492 histone modification (GO:0016570) 1/293 0.9485186 1.0000000 0 0 0.3412969 0.0180389 HOPX
1493 covalent chromatin modification (GO:0016569) 1/296 0.9500701 1.0000000 0 0 0.3378378 0.0173039 HOPX
1494 glycerolipid metabolic process (GO:0046486) 1/296 0.9500701 1.0000000 0 0 0.3378378 0.0173039 PLA2G1B
1495 nuclear division (GO:0000280) 1/298 0.9510786 1.0000000 0 0 0.3355705 0.0168317 MEIOB
1496 response to extracellular stimulus (GO:0009991) 1/313 0.9580230 1.0000000 0 0 0.3194888 0.0137008 ABCG2
1497 sulfur compound metabolic process (GO:0006790) 1/314 0.9584494 1.0000000 0 0 0.3184713 0.0135154 GPC3
1498 multicellular organismal reproductive process (GO:0048609) 2/491 0.9588501 1.0000000 0 0 0.4073320 0.0171163 DMRT1;ABCG2
1499 single-organism cellular localization (GO:1902580) 2/496 0.9605755 1.0000000 0 0 0.4032258 0.0162188 RAMP2;FGF9
1500 organelle fission (GO:0048285) 1/325 0.9628649 1.0000000 0 0 0.3076923 0.0116437 MEIOB
1501 apoptotic signaling pathway (GO:0097190) 1/327 0.9636160 1.0000000 0 0 0.3058104 0.0113341 ZNF385B
1502 positive regulation of organelle organization (GO:0010638) 1/340 0.9681429 1.0000000 0 0 0.2941176 0.0095222 DMRT1
1503 regulation of Ras GTPase activity (GO:0032318) 1/349 0.9709441 1.0000000 0 0 0.2865330 0.0084488 DLC1
1504 regulation of cytoskeleton organization (GO:0051493) 1/350 0.9712398 1.0000000 0 0 0.2857143 0.0083377 DLC1
1505 cellular component disassembly (GO:0022411) 1/350 0.9712398 1.0000000 0 0 0.2857143 0.0083377 FBN1
1506 spermatogenesis (GO:0007283) 1/353 0.9721090 1.0000000 0 0 0.2832861 0.0080134 DMRT1
1507 male gamete generation (GO:0048232) 1/354 0.9723929 1.0000000 0 0 0.2824859 0.0079083 DMRT1
1508 regulation of apoptotic signaling pathway (GO:2001233) 1/356 0.9729521 1.0000000 0 0 0.2808989 0.0077024 CX3CR1
1509 gamete generation (GO:0007276) 1/390 0.9809052 1.0000000 0 0 0.2564103 0.0049435 DMRT1
1510 regulation of mitotic cell cycle (GO:0007346) 1/391 0.9810999 1.0000000 0 0 0.2557545 0.0048800 DMRT1
1511 regulation of intracellular transport (GO:0032386) 1/394 0.9816723 1.0000000 0 0 0.2538071 0.0046949 PLA2G1B
1512 protein localization to organelle (GO:0033365) 1/396 0.9820443 1.0000000 0 0 0.2525253 0.0045755 FGF9
1513 mRNA processing (GO:0006397) 1/397 0.9822274 1.0000000 0 0 0.2518892 0.0045170 APOBEC2
1514 DNA repair (GO:0006281) 1/403 0.9832880 1.0000000 0 0 0.2481390 0.0041819 MEIOB
1515 regulation of cellular response to stress (GO:0080135) 1/404 0.9834585 1.0000000 0 0 0.2475248 0.0041287 FLT4
1516 detection of chemical stimulus involved in sensory perception of smell (GO:0050911) 1/420 0.9859630 1.0000000 0 0 0.2380952 0.0033658 OR51E2
1517 microtubule-based process (GO:0007017) 1/437 0.9882116 1.0000000 0 0 0.2288330 0.0027136 KIF12
1518 detection of chemical stimulus involved in sensory perception (GO:0050907) 1/465 0.9911602 1.0000000 0 0 0.2150538 0.0019095 OR51E2
1519 transcription from RNA polymerase II promoter (GO:0006366) 1/470 0.9916034 1.0000000 0 0 0.2127660 0.0017940 HLF
1520 chromatin modification (GO:0016568) 1/475 0.9920246 1.0000000 0 0 0.2105263 0.0016858 HOPX
1521 regulation of cell cycle process (GO:0010564) 1/481 0.9925023 1.0000000 0 0 0.2079002 0.0015647 DMRT1
1522 positive regulation of GTPase activity (GO:0043547) 1/482 0.9925791 1.0000000 0 0 0.2074689 0.0015454 DLC1
1523 positive regulation of GTP catabolic process (GO:0033126) 1/483 0.9926551 1.0000000 0 0 0.2070393 0.0015263 DLC1
1524 detection of chemical stimulus (GO:0009593) 1/499 0.9937711 1.0000000 0 0 0.2004008 0.0012522 OR51E2

GO_Cellular_Component_2015

go_cellular %>%
  knitr::kable(
    format = "html", align = rep("c", ncol(go_cellular) + 1),
    row.names = TRUE
  ) %>%
  kableExtra::kable_styling() %>%
  kableExtra::scroll_box(height = "300px")
Term Overlap P.value Adjusted.P.value Old.P.value Old.Adjusted.P.value Odds.Ratio Combined.Score Genes
1 integral component of plasma membrane (GO:0005887) 26/1066 0.0000240 0.0153709 0 0 2.4390244 25.9470911 CX3CR1;RAMP2;HHIP;FLT4;GRIK1;GJA1;KLRK1;TSPAN7;GPC3;CNGA1;GABRD;JAM2;CLCA4;TRGC2;TMPRSS11A;CD52;GABBR2;SLC6A13;SYT13;TMPRSS11E;TMPRSS11F;OPN1SW;CD8B;BPI;LGR5;KCNK3
2 proteinaceous extracellular matrix (GO:0005578) 8/239 0.0028629 0.9175744 0 0 3.3472803 19.6013520 ADAMTSL1;SMOC2;ECM2;SFTPD;GPC3;SPARCL1;EMID1;FBN1
3 microfibril (GO:0001527) 2/9 0.0034202 0.7307895 0 0 22.2222222 126.1788209 MFAP4;FBN1
4 voltage-gated potassium channel complex (GO:0008076) 4/70 0.0053199 0.8525140 0 0 5.7142857 29.9217183 KCNJ6;KCNA3;KCNA4;KCNJ1
5 potassium channel complex (GO:0034705) 4/71 0.0055942 0.7171766 0 0 5.6338028 29.2170409 KCNJ6;KCNA3;KCNA4;KCNJ1
6 receptor complex (GO:0043235) 8/272 0.0061980 0.6621583 0 0 2.9411765 14.9515311 GABBR2;RAMP2;CD8B;GRID1;FLT4;LEPR;GRIK1;LRP1B
7 fibril (GO:0043205) 2/13 0.0072181 0.6609718 0 0 15.3846154 75.8640519 MFAP4;FBN1
8 extracellular matrix (GO:0031012) 9/348 0.0085495 0.6850315 0 0 2.5862069 12.3152028 ADAMTSL1;SMOC2;MFAP4;ECM2;SFTPD;GPC3;SPARCL1;EMID1;FBN1
9 interstitial matrix (GO:0005614) 2/15 0.0095900 0.6830217 0 0 13.3333333 61.9604467 SMOC2;ECM2
10 photoreceptor outer segment membrane (GO:0042622) 2/16 0.0108884 0.6979480 0 0 12.5000000 56.5006873 OPN1SW;CNGA1
11 MHC class II protein complex (GO:0042613) 2/18 0.0137022 0.7984648 0 0 11.1111111 47.6688727 HLA-DOA;HLA-DQB2
12 postsynaptic membrane (GO:0045211) 6/195 0.0138327 0.7388954 0 0 3.0769231 13.1714514 CNKSR2;GABBR2;CAMK2N1;GRID1;GRIK1;GABRD
13 extrinsic component of plasma membrane (GO:0019897) 3/52 0.0152014 0.7495468 0 0 5.7692308 24.1521154 SCUBE1;MYZAP;TGM3
14 ion channel complex (GO:0034702) 7/258 0.0153427 0.7024774 0 0 2.7131783 11.3332554 KCNJ6;GRID1;KCNA3;KCNA4;GRIK1;GABRD;KCNJ1
15 neuronal cell body (GO:0043025) 7/270 0.0191830 0.8197530 0 0 2.5925926 10.2504148 CNKSR2;KISS1;SLC5A7;GPM6A;DDC;CAMK2N1;SNCG
16 multivesicular body (GO:0005771) 2/23 0.0219305 0.8785902 0 0 8.6956522 33.2163252 GJA1;HLA-DQB2
17 transmembrane transporter complex (GO:1902495) 7/286 0.0252891 0.9535466 0 0 2.4475524 9.0005880 KCNJ6;GRID1;KCNA3;KCNA4;GRIK1;GABRD;KCNJ1
18 synaptic membrane (GO:0097060) 6/228 0.0273927 0.9754837 0 0 2.6315789 9.4670514 CNKSR2;GABBR2;CAMK2N1;GRID1;GRIK1;GABRD
19 transporter complex (GO:1990351) 7/291 0.0274425 0.9258227 0 0 2.4054983 8.6493612 KCNJ6;GRID1;KCNA3;KCNA4;GRIK1;GABRD;KCNJ1
20 extrinsic component of cytoplasmic side of plasma membrane (GO:0031234) 2/26 0.0276272 0.8854512 0 0 7.6923077 27.6073469 MYZAP;TGM3
21 cell surface (GO:0009986) 9/437 0.0321362 0.9809188 0 0 2.0594966 7.0800809 ROBO2;RAMP2;KLRK1;SCUBE1;KRT4;PLA2G1B;HHIP;ANXA9;GPR124
22 extracellular space (GO:0005615) 18/1120 0.0321818 0.9376619 0 0 1.6071429 5.5227100 PLA2G1B;PROS1;A2ML1;SOGA3;SLURP1;KISS1;IGHG4;NPPC;FABP3;SCUBE1;FGF9;CCL5;FGF18;SCGB1A1;SPARCL1;SCGB3A1;KIAA0408;FBN1
23 MHC protein complex (GO:0042611) 2/29 0.0338475 0.9433138 0 0 6.8965517 23.3509763 HLA-DOA;HLA-DQB2
24 clathrin-coated endocytic vesicle membrane (GO:0030669) 2/31 0.0382674 1.0000000 0 0 6.4516129 21.0526212 CD207;HLA-DQB2
25 extracellular matrix part (GO:0044420) 4/127 0.0388027 0.9949012 0 0 3.1496063 10.2339070 MFAP4;SMOC2;FGF9;FBN1
26 cell body (GO:0044297) 7/315 0.0395159 0.9742195 0 0 2.2222222 7.1801146 CNKSR2;KISS1;SLC5A7;GPM6A;DDC;CAMK2N1;SNCG
27 basement membrane (GO:0005604) 3/77 0.0420316 0.9978620 0 0 3.8961039 12.3480501 SMOC2;FGF9;FBN1
28 synapse part (GO:0044456) 8/395 0.0456112 1.0000000 0 0 2.0253165 6.2533689 CNKSR2;GABBR2;DDC;CAMK2N1;GRID1;GRIK1;GABRD;PPFIA2
29 extracellular region (GO:0005576) 23/1585 0.0456295 1.0000000 0 0 1.4511041 4.4798508 TMPRSS11A;PCOLCE2;PLA2G1B;HHIP;PROS1;FLT4;SFTPD;PRSS27;A2ML1;TMPRSS11E;TMPRSS11F;SLURP1;KISS1;IGHG4;MFAP4;FGF9;CD8B;CCL5;FGF18;LEPR;SCG5;HCG22;FBN1
30 early endosome membrane (GO:0031901) 2/39 0.0579156 1.0000000 0 0 5.1282051 14.6090715 CD8B;CD207
31 cation channel complex (GO:0034703) 4/147 0.0603096 1.0000000 0 0 2.7210884 7.6415355 KCNJ6;KCNA3;KCNA4;KCNJ1
32 trans-Golgi network membrane (GO:0032588) 2/42 0.0660116 1.0000000 0 0 4.7619048 12.9424984 LGR5;HLA-DQB2
33 extracellular vesicular exosome (GO:0070062) 35/2717 0.0677648 1.0000000 0 0 1.2881855 3.4674249 ROBO2;GPM6A;DDC;PCOLCE2;PROS1;QPRT;KIF12;ALOX12;SEC14L3;IGHG4;ISLR;GJA1;FGF9;GPC3;SNCG;ANXA9;TGM3;CLCA4;PPFIA2;GRID1;SLC6A13;A2ML1;CYS1;CNFN;DUSP26;SLURP1;CNKSR2;MFAP4;FABP3;SCGB1A1;SPARCL1;SCGB3A1;BPI;ZNF114;FBN1
34 ciliary membrane (GO:0060170) 2/43 0.0687896 1.0000000 0 0 4.6511628 12.4497769 OPN1SW;CNGA1
35 neuronal cell body membrane (GO:0032809) 1/8 0.0772681 1.0000000 0 0 12.5000000 32.0059307 CX3CR1
36 cell body membrane (GO:0044298) 1/8 0.0772681 1.0000000 0 0 12.5000000 32.0059307 CX3CR1
37 clathrin-coated vesicle membrane (GO:0030665) 2/48 0.0832284 1.0000000 0 0 4.1666667 10.3590263 CD207;HLA-DQB2
38 ionotropic glutamate receptor complex (GO:0008328) 2/49 0.0862189 1.0000000 0 0 4.0816327 10.0035323 GRID1;GRIK1
39 secretory granule (GO:0030141) 4/176 0.1005270 1.0000000 0 0 2.2727273 5.2212019 NPPC;PLA2G1B;SCGB1A1;SCG5
40 plasma membrane region (GO:0098590) 7/395 0.1023945 1.0000000 0 0 1.7721519 4.0385962 KISS1;GJA1;OPN1SW;DLC1;SLC4A10;CNGA1;ABCG2
41 extrinsic component of membrane (GO:0019898) 3/115 0.1084360 1.0000000 0 0 2.6086957 5.7954655 SCUBE1;MYZAP;TGM3
42 Golgi-associated vesicle membrane (GO:0030660) 1/12 0.1136443 1.0000000 0 0 8.3333333 18.1223455 GJA1
43 cytoplasmic membrane-bounded vesicle (GO:0016023) 8/492 0.1214544 1.0000000 0 0 1.6260163 3.4279944 NPPC;DDC;PLA2G1B;CD207;SFTPD;SCGB1A1;SCG5;SYT13
44 axolemma (GO:0030673) 1/13 0.1225132 1.0000000 0 0 7.6923077 16.1502800 ROBO2
45 fascia adherens (GO:0005916) 1/13 0.1225132 1.0000000 0 0 7.6923077 16.1502800 GJA1
46 axonal growth cone (GO:0044295) 1/13 0.1225132 1.0000000 0 0 7.6923077 16.1502800 GPM6A
47 external side of plasma membrane (GO:0009897) 4/191 0.1251565 1.0000000 0 0 2.0942408 4.3522307 SCUBE1;CD8B;FCRL6;HLA-DQB2
48 T cell receptor complex (GO:0042101) 1/14 0.1312938 1.0000000 0 0 7.1428571 14.5022708 CD8B
49 gap junction (GO:0005921) 1/15 0.1399869 1.0000000 0 0 6.6666667 13.1080425 GJA1
50 coated vesicle membrane (GO:0030662) 2/66 0.1412394 1.0000000 0 0 3.0303030 5.9312088 CD207;HLA-DQB2
51 axon part (GO:0033267) 3/133 0.1485253 1.0000000 0 0 2.2556391 4.3015042 ROBO2;GPM6A;SNCG
52 neuronal postsynaptic density (GO:0097481) 1/18 0.1655504 1.0000000 0 0 5.5555556 9.9915545 GRIK1
53 I band (GO:0031674) 1/19 0.1739024 1.0000000 0 0 5.2631579 9.2066381 MYZAP
54 anchored component of membrane (GO:0031225) 3/150 0.1900320 1.0000000 0 0 2.0000000 3.3211257 CD52;LYPD1;GPC3
55 cornified envelope (GO:0001533) 1/23 0.2064868 1.0000000 0 0 4.3478261 6.8587782 CNFN
56 side of membrane (GO:0098552) 4/235 0.2094034 1.0000000 0 0 1.7021277 2.6612640 SCUBE1;CD8B;FCRL6;HLA-DQB2
57 Golgi lumen (GO:0005796) 2/86 0.2125388 1.0000000 0 0 2.3255814 3.6014667 PROS1;GPC3
58 cortical actin cytoskeleton (GO:0030864) 1/24 0.2144310 1.0000000 0 0 4.1666667 6.4156966 MYZAP
59 connexon complex (GO:0005922) 1/24 0.2144310 1.0000000 0 0 4.1666667 6.4156966 GJA1
60 presynaptic active zone (GO:0048786) 1/25 0.2222961 1.0000000 0 0 4.0000000 6.0149794 PPFIA2
61 collagen trimer (GO:0005581) 2/91 0.2309240 1.0000000 0 0 2.1978022 3.2212458 SFTPD;EMID1
62 endocytic vesicle membrane (GO:0030666) 2/94 0.2420055 1.0000000 0 0 2.1276596 3.0187127 CD207;HLA-DQB2
63 integral component of lumenal side of endoplasmic reticulum membrane (GO:0071556) 1/28 0.2454244 1.0000000 0 0 3.5714286 5.0170219 HLA-DQB2
64 endocytic vesicle (GO:0030139) 2/96 0.2494068 1.0000000 0 0 2.0833333 2.8930625 SFTPD;CD207
65 postsynaptic density (GO:0014069) 2/98 0.2568151 1.0000000 0 0 2.0408163 2.7742832 CAMK2N1;GRIK1
66 ER to Golgi transport vesicle membrane (GO:0012507) 1/30 0.2604618 1.0000000 0 0 3.3333333 4.4843302 HLA-DQB2
67 lysosome (GO:0005764) 4/261 0.2651645 1.0000000 0 0 1.5325670 2.0343371 GJA1;RAMP2;SFTPD;SLC7A14
68 lytic vacuole (GO:0000323) 4/261 0.2651645 1.0000000 0 0 1.5325670 2.0343371 GJA1;RAMP2;SFTPD;SLC7A14
69 axon terminus (GO:0043679) 1/34 0.2896478 1.0000000 0 0 2.9411765 3.6443812 SNCG
70 late endosome (GO:0005770) 2/107 0.2901569 1.0000000 0 0 1.8691589 2.3127732 GJA1;HLA-DQB2
71 neuron projection membrane (GO:0032589) 1/35 0.2967634 1.0000000 0 0 2.8571429 3.4709146 ROBO2
72 rough endoplasmic reticulum (GO:0005791) 1/35 0.2967634 1.0000000 0 0 2.8571429 3.4709146 SCGB1A1
73 contractile fiber (GO:0043292) 1/36 0.3038081 1.0000000 0 0 2.7777778 3.3093308 GJA1
74 intercalated disc (GO:0014704) 1/37 0.3107825 1.0000000 0 0 2.7027027 3.1585455 GJA1
75 cell projection membrane (GO:0031253) 3/196 0.3123712 1.0000000 0 0 1.5306122 1.7809638 ROBO2;OPN1SW;CNGA1
76 membrane raft (GO:0045121) 3/200 0.3233045 1.0000000 0 0 1.5000000 1.6937411 GJA1;DLC1;KCNA3
77 apical plasma membrane (GO:0016324) 3/201 0.3260385 1.0000000 0 0 1.4925373 1.6727460 KISS1;GJA1;ABCG2
78 anchored component of plasma membrane (GO:0046658) 1/40 0.3312915 1.0000000 0 0 2.5000000 2.7618913 GPC3
79 vacuole (GO:0005773) 4/293 0.3368702 1.0000000 0 0 1.3651877 1.4854027 GJA1;RAMP2;SFTPD;SLC7A14
80 transport vesicle membrane (GO:0030658) 1/41 0.3379920 1.0000000 0 0 2.4390244 2.6456903 HLA-DQB2
81 presynaptic membrane (GO:0042734) 1/44 0.3576952 1.0000000 0 0 2.2727273 2.3365317 GRIK1
82 cell-cell contact zone (GO:0044291) 1/44 0.3576952 1.0000000 0 0 2.2727273 2.3365317 GJA1
83 neuron projection terminus (GO:0044306) 1/44 0.3576952 1.0000000 0 0 2.2727273 2.3365317 SNCG
84 lateral plasma membrane (GO:0016328) 1/46 0.3705054 1.0000000 0 0 2.1739130 2.1584503 GJA1
85 cell-cell adherens junction (GO:0005913) 1/47 0.3768149 1.0000000 0 0 2.1276596 2.0765984 GJA1
86 filopodium (GO:0030175) 1/48 0.3830614 1.0000000 0 0 2.0833333 1.9990833 GPM6A
87 platelet alpha granule lumen (GO:0031093) 1/48 0.3830614 1.0000000 0 0 2.0833333 1.9990833 PROS1
88 cortical cytoskeleton (GO:0030863) 1/50 0.3953682 1.0000000 0 0 2.0000000 1.8558758 MYZAP
89 cytoplasmic mRNA processing body (GO:0000932) 1/50 0.3953682 1.0000000 0 0 2.0000000 1.8558758 APOBEC3H
90 chloride channel complex (GO:0034707) 1/50 0.3953682 1.0000000 0 0 2.0000000 1.8558758 GABRD
91 cytoplasmic vesicle membrane (GO:0030659) 3/229 0.4021216 1.0000000 0 0 1.3100437 1.1934508 GJA1;CD207;HLA-DQB2
92 microtubule associated complex (GO:0005875) 2/138 0.4023514 1.0000000 0 0 1.4492754 1.3194631 DCX;KIF12
93 early endosome (GO:0005769) 2/141 0.4128121 1.0000000 0 0 1.4184397 1.2549827 GJA1;HLA-DQB2
94 kinesin complex (GO:0005871) 1/53 0.4133717 1.0000000 0 0 1.8867925 1.6668075 KIF12
95 coated pit (GO:0005905) 1/54 0.4192536 1.0000000 0 0 1.8518519 1.6097765 RAMP2
96 dendrite (GO:0030425) 3/236 0.4208286 1.0000000 0 0 1.2711864 1.1002496 CAMK2N1;GRID1;GRIK1
97 intermediate filament cytoskeleton (GO:0045111) 1/55 0.4250768 1.0000000 0 0 1.8181818 1.5554281 KRT4
98 cell-cell junction (GO:0005911) 4/335 0.4316984 1.0000000 0 0 1.1940299 1.0030187 GJA1;KIAA1462;SKAP1;JAM2
99 plasma membrane raft (GO:0044853) 1/58 0.4422000 1.0000000 0 0 1.7241379 1.4068845 DLC1
100 caveola (GO:0005901) 1/58 0.4422000 1.0000000 0 0 1.7241379 1.4068845 DLC1
101 vesicle membrane (GO:0012506) 3/249 0.4550271 1.0000000 0 0 1.2048193 0.9486727 GJA1;CD207;HLA-DQB2
102 secretory granule lumen (GO:0034774) 1/62 0.4642441 1.0000000 0 0 1.6129032 1.2376529 PROS1
103 transport vesicle (GO:0030133) 1/62 0.4642441 1.0000000 0 0 1.6129032 1.2376529 SYT13
104 endoplasmic reticulum membrane (GO:0005789) 5/449 0.4675027 1.0000000 0 0 1.1135857 0.8467150 GJA1;CYP2W1;CYP2A13;PROS1;CYP2F1
105 sarcolemma (GO:0042383) 1/63 0.4696183 1.0000000 0 0 1.5873016 1.1997381 ALOX12
106 nuclear matrix (GO:0016363) 1/64 0.4749389 1.0000000 0 0 1.5625000 1.1633893 RUNX1T1
107 blood microparticle (GO:0072562) 2/161 0.4800636 1.0000000 0 0 1.2422360 0.9115984 IGHG4;PROS1
108 lysosomal lumen (GO:0043202) 1/67 0.4905840 1.0000000 0 0 1.4925373 1.0629235 GPC3
109 cytoplasmic vesicle part (GO:0044433) 4/363 0.4930163 1.0000000 0 0 1.1019284 0.7792982 GJA1;PROS1;CD207;HLA-DQB2
110 vacuolar lumen (GO:0005775) 1/70 0.5057652 1.0000000 0 0 1.4285714 0.9738324 GPC3
111 endosome membrane (GO:0010008) 2/175 0.5242613 1.0000000 0 0 1.1428571 0.7380171 CD8B;CD207
112 vesicle lumen (GO:0031983) 1/76 0.5347903 1.0000000 0 0 1.3157895 0.8235271 PROS1
113 cytoplasmic membrane-bounded vesicle lumen (GO:0060205) 1/76 0.5347903 1.0000000 0 0 1.3157895 0.8235271 PROS1
114 vacuolar part (GO:0044437) 3/285 0.5448057 1.0000000 0 0 1.0526316 0.6392906 GPC3;HLA-DOA;HLA-DQB2
115 synaptic vesicle (GO:0008021) 1/86 0.5794443 1.0000000 0 0 1.1627907 0.6345183 DDC
116 intermediate filament (GO:0005882) 2/196 0.5856881 1.0000000 0 0 1.0204082 0.5458856 GJA1;KRT4
117 lysosomal membrane (GO:0005765) 2/196 0.5856881 1.0000000 0 0 1.0204082 0.5458856 HLA-DOA;HLA-DQB2
118 endosomal part (GO:0044440) 2/200 0.5967066 1.0000000 0 0 1.0000000 0.5163298 CD8B;CD207
119 Golgi membrane (GO:0000139) 3/308 0.5974940 1.0000000 0 0 0.9740260 0.5016341 GJA1;PROS1;HLA-DQB2
120 integral component of endoplasmic reticulum membrane (GO:0030176) 1/94 0.6120753 1.0000000 0 0 1.0638298 0.5222340 HLA-DQB2
121 leading edge membrane (GO:0031256) 1/95 0.6159728 1.0000000 0 0 1.0526316 0.5100552 ROBO2
122 vacuolar membrane (GO:0005774) 2/208 0.6180843 1.0000000 0 0 0.9615385 0.4626254 HLA-DOA;HLA-DQB2
123 keratin filament (GO:0045095) 1/98 0.6274332 1.0000000 0 0 1.0204082 0.4756306 KRT4
124 growth cone (GO:0030426) 1/99 0.6311772 1.0000000 0 0 1.0101010 0.4648167 GPM6A
125 site of polarized growth (GO:0030427) 1/102 0.6421861 1.0000000 0 0 0.9803922 0.4341933 GPM6A
126 cell cortex part (GO:0044448) 1/105 0.6528680 1.0000000 0 0 0.9523810 0.4060766 MYZAP
127 ciliary part (GO:0044441) 2/223 0.6558105 1.0000000 0 0 0.8968610 0.3783707 OPN1SW;CNGA1
128 occluding junction (GO:0070160) 1/108 0.6632325 1.0000000 0 0 0.9259259 0.3802127 JAM2
129 tight junction (GO:0005923) 1/108 0.6632325 1.0000000 0 0 0.9259259 0.3802127 JAM2
130 peroxisome (GO:0005777) 1/109 0.6666184 1.0000000 0 0 0.9174312 0.3720527 ACOXL
131 nuclear envelope (GO:0005635) 1/110 0.6699705 1.0000000 0 0 0.9090909 0.3641106 SCGB1A1
132 ribonucleoprotein granule (GO:0035770) 1/111 0.6732890 1.0000000 0 0 0.9009009 0.3563789 APOBEC3H
133 cytoplasmic ribonucleoprotein granule (GO:0036464) 1/111 0.6732890 1.0000000 0 0 0.9009009 0.3563789 APOBEC3H
134 mitochondrial outer membrane (GO:0005741) 1/118 0.6956073 1.0000000 0 0 0.8474576 0.3076017 GJA1
135 organelle envelope (GO:0031967) 1/123 0.7106138 1.0000000 0 0 0.8130081 0.2777449 SCGB1A1
136 microbody (GO:0042579) 1/123 0.7106138 1.0000000 0 0 0.8130081 0.2777449 ACOXL
137 envelope (GO:0031975) 1/123 0.7106138 1.0000000 0 0 0.8130081 0.2777449 SCGB1A1
138 organelle outer membrane (GO:0031968) 1/131 0.7331076 1.0000000 0 0 0.7633588 0.2369945 GJA1
139 outer membrane (GO:0019867) 1/137 0.7488283 1.0000000 0 0 0.7299270 0.2111281 GJA1
140 basolateral plasma membrane (GO:0016323) 1/138 0.7513574 1.0000000 0 0 0.7246377 0.2071550 SLC4A10
141 Golgi apparatus (GO:0005794) 7/865 0.7667659 1.0000000 0 0 0.8092486 0.2149152 CNKSR2;GJA1;KCNJ6;ST6GAL2;DUSP26;EMID1;JAKMIP2
142 axon (GO:0030424) 1/161 0.8030171 1.0000000 0 0 0.6211180 0.1362604 DDC
143 chromosome (GO:0005694) 1/166 0.8127489 1.0000000 0 0 0.6024096 0.1248994 MEIOB
144 contractile fiber part (GO:0044449) 1/167 0.8146371 1.0000000 0 0 0.5988024 0.1227620 MYZAP
145 actin cytoskeleton (GO:0015629) 1/193 0.8576013 1.0000000 0 0 0.5181347 0.0795938 MYOZ1
146 focal adhesion (GO:0005925) 2/352 0.8698337 1.0000000 0 0 0.5681818 0.0792348 GJA1;DLC1
147 cell-substrate adherens junction (GO:0005924) 2/358 0.8759198 1.0000000 0 0 0.5586592 0.0740116 GJA1;DLC1
148 microtubule (GO:0005874) 2/360 0.8778898 1.0000000 0 0 0.5555556 0.0723523 DCX;KIF12
149 cell-substrate junction (GO:0030055) 2/362 0.8798311 1.0000000 0 0 0.5524862 0.0707322 GJA1;DLC1
150 integral component of organelle membrane (GO:0031301) 1/211 0.8813857 1.0000000 0 0 0.4739336 0.0598388 HLA-DQB2
151 synapse (GO:0045202) 1/243 0.9143243 1.0000000 0 0 0.4115226 0.0368601 FRRS1L
152 cilium (GO:0005929) 1/243 0.9143243 1.0000000 0 0 0.4115226 0.0368601 CYS1
153 adherens junction (GO:0005912) 2/405 0.9152623 1.0000000 0 0 0.4938272 0.0437257 GJA1;DLC1
154 perinuclear region of cytoplasm (GO:0048471) 2/411 0.9193490 1.0000000 0 0 0.4866180 0.0409195 CX3CR1;SNCG
155 anchoring junction (GO:0070161) 2/419 0.9245113 1.0000000 0 0 0.4773270 0.0374654 GJA1;DLC1
156 transcription factor complex (GO:0005667) 1/268 0.9335761 1.0000000 0 0 0.3731343 0.0256466 BEX1
157 intracellular (GO:0005622) 4/730 0.9369519 1.0000000 0 0 0.5479452 0.0356840 SEC14L3;ZNF728;DCX;ZNF114
158 mitochondrial membrane (GO:0031966) 1/457 0.9904020 1.0000000 0 0 0.2188184 0.0021104 GJA1
159 cytosol (GO:0005829) 15/2529 0.9928792 1.0000000 0 0 0.5931198 0.0042386 DDC;ADH1C;STAC;ADH1B;QPRT;ALOX12;IFIT1;OASL;CH25H;GJA1;FABP3;DLC1;DCX;UBASH3A;ANXA9
160 mitochondrion (GO:0005739) 2/1269 0.9999686 1.0000000 0 0 0.1576044 0.0000049 DUSP26;ABCG2
161 nucleolus (GO:0005730) 2/1653 0.9999955 1.0000000 0 0 0.1209921 0.0000005 FGF18;OASL

GO_Molecular_Function_2015

go_molecular %>%
  knitr::kable(
    format = "html", align = rep("c", ncol(go_molecular) + 1),
    row.names = TRUE
  ) %>%
  kableExtra::kable_styling() %>%
  kableExtra::scroll_box(height = "300px")
Term Overlap P.value Adjusted.P.value Old.P.value Old.Adjusted.P.value Odds.Ratio Combined.Score Genes
1 voltage-gated potassium channel activity (GO:0005249) 6/86 0.0002244 0.2549732 0 0 6.9767442 58.6176657 KCNJ6;CNGA1;KCNA3;KCNA4;KCNJ1;KCNK3
2 potassium channel activity (GO:0005267) 6/118 0.0012087 0.6865446 0 0 5.0847458 34.1603669 KCNJ6;CNGA1;KCNA3;KCNA4;KCNJ1;KCNK3
3 channel activity (GO:0015267) 12/427 0.0012766 0.4834037 0 0 2.8103044 18.7266307 GPM6A;GJA1;KCNJ6;GRID1;KCNA3;CNGA1;KCNA4;GRIK1;GABRD;KCNJ1;CLCA4;KCNK3
4 passive transmembrane transporter activity (GO:0022803) 12/427 0.0012766 0.3625528 0 0 2.8103044 18.7266307 GPM6A;GJA1;KCNJ6;GRID1;KCNA3;CNGA1;KCNA4;GRIK1;GABRD;KCNJ1;CLCA4;KCNK3
5 iron ion binding (GO:0005506) 7/172 0.0017549 0.3987215 0 0 4.0697674 25.8239879 CH25H;CYP2W1;CYP2A13;P4HA3;ALOX12;CYP4F22;CYP2F1
6 ion channel activity (GO:0005216) 11/396 0.0022098 0.4183888 0 0 2.7777778 16.9857035 GPM6A;KCNJ6;GRID1;KCNA3;CNGA1;KCNA4;GRIK1;GABRD;KCNJ1;CLCA4;KCNK3
7 potassium ion transmembrane transporter activity (GO:0015079) 6/138 0.0026751 0.4341297 0 0 4.3478261 25.7555234 KCNJ6;CNGA1;KCNA3;KCNA4;KCNJ1;KCNK3
8 substrate-specific channel activity (GO:0022838) 11/406 0.0026774 0.3801896 0 0 2.7093596 16.0472995 GPM6A;KCNJ6;GRID1;KCNA3;CNGA1;KCNA4;GRIK1;GABRD;KCNJ1;CLCA4;KCNK3
9 alcohol dehydrogenase (NAD) activity (GO:0004022) 2/8 0.0026778 0.3379938 0 0 25.0000000 148.0692967 ADH1C;ADH1B
10 cytidine deaminase activity (GO:0004126) 2/8 0.0026778 0.3041944 0 0 25.0000000 148.0692967 APOBEC2;APOBEC3H
11 monooxygenase activity (GO:0004497) 5/99 0.0031830 0.3287152 0 0 5.0505051 29.0400857 CH25H;CYP2W1;CYP2A13;CYP4F22;CYP2F1
12 ligand-gated ion channel activity (GO:0015276) 6/145 0.0034178 0.3235552 0 0 4.1379310 23.4982656 KCNJ6;GRID1;CNGA1;GRIK1;KCNJ1;GABRD
13 ligand-gated channel activity (GO:0022834) 6/145 0.0034178 0.2986663 0 0 4.1379310 23.4982656 KCNJ6;GRID1;CNGA1;GRIK1;KCNJ1;GABRD
14 voltage-gated cation channel activity (GO:0022843) 6/149 0.0039058 0.3169247 0 0 4.0268456 22.3300765 KCNJ6;CNGA1;KCNA3;KCNA4;KCNJ1;KCNK3
15 MHC class II receptor activity (GO:0032395) 2/11 0.0051570 0.3905584 0 0 18.1818182 95.7708415 HLA-DOA;HLA-DQB2
16 gated channel activity (GO:0022836) 9/323 0.0053542 0.3801493 0 0 2.7863777 14.5723959 KCNJ6;GRID1;KCNA3;CNGA1;KCNA4;GRIK1;GABRD;KCNJ1;KCNK3
17 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen (GO:0016705) 6/163 0.0060252 0.4026243 0 0 3.6809816 18.8164667 CH25H;CYP2W1;CYP2A13;P4HA3;CYP4F22;CYP2F1
18 voltage-gated channel activity (GO:0022832) 6/189 0.0120086 0.7578743 0 0 3.1746032 14.0385224 KCNJ6;CNGA1;KCNA3;KCNA4;KCNJ1;KCNK3
19 voltage-gated ion channel activity (GO:0005244) 6/189 0.0120086 0.7179862 0 0 3.1746032 14.0385224 KCNJ6;CNGA1;KCNA3;KCNA4;KCNJ1;KCNK3
20 extracellular-glutamate-gated ion channel activity (GO:0005234) 2/18 0.0137022 0.7782852 0 0 11.1111111 47.6688727 GRID1;GRIK1
21 ionotropic glutamate receptor activity (GO:0004970) 2/19 0.0152144 0.8230292 0 0 10.5263158 44.0579974 GRID1;GRIK1
22 aromatase activity (GO:0070330) 2/21 0.0184420 0.9522790 0 0 9.5238095 38.0297462 CYP2A13;CYP2F1
23 metal ion transmembrane transporter activity (GO:0046873) 9/400 0.0196012 0.9681294 0 0 2.2500000 8.8473688 SLC5A7;GPM6A;KCNJ6;SLC6A13;KCNA3;CNGA1;KCNA4;KCNJ1;KCNK3
24 GABA receptor activity (GO:0016917) 2/22 0.0201544 0.9539738 0 0 9.0909091 35.4939443 GABBR2;GABRD
25 inward rectifier potassium channel activity (GO:0005242) 2/22 0.0201544 0.9158148 0 0 9.0909091 35.4939443 KCNJ6;KCNJ1
26 monovalent inorganic cation transmembrane transporter activity (GO:0015077) 8/343 0.0224125 0.9792545 0 0 2.3323615 8.8586258 SLC5A7;KCNJ6;SLC6A13;KCNA3;CNGA1;KCNA4;KCNJ1;KCNK3
27 fibroblast growth factor receptor binding (GO:0005104) 2/24 0.0237689 1.0000000 0 0 8.3333333 31.1614659 FGF9;FGF18
28 cation channel activity (GO:0005261) 7/285 0.0248727 1.0000000 0 0 2.4561404 9.0729396 GPM6A;KCNJ6;KCNA3;CNGA1;KCNA4;KCNJ1;KCNK3
29 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen (GO:0016712) 2/25 0.0256683 1.0000000 0 0 8.0000000 29.2999902 CYP2A13;CYP2F1
30 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen (GO:0016702) 2/25 0.0256683 0.9719727 0 0 8.0000000 29.2999902 P4HA3;ALOX12
31 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen (GO:0016701) 2/26 0.0276272 1.0000000 0 0 7.6923077 27.6073469 P4HA3;ALOX12
32 amino acid transmembrane transporter activity (GO:0015171) 3/66 0.0284510 1.0000000 0 0 4.5454545 16.1798713 SLC7A14;SLC6A13;SLC38A4
33 glutamate receptor activity (GO:0008066) 2/27 0.0296442 1.0000000 0 0 7.4074074 26.0628716 GRID1;GRIK1
34 coreceptor activity (GO:0015026) 2/27 0.0296442 0.9904662 0 0 7.4074074 26.0628716 RAMP2;CD8B
35 deaminase activity (GO:0019239) 2/29 0.0338475 1.0000000 0 0 6.8965517 23.3509763 APOBEC2;APOBEC3H
36 anion transmembrane transporter activity (GO:0008509) 6/245 0.0369668 1.0000000 0 0 2.4489796 8.0760842 SLC6A13;SLC7A14;SLC4A10;GABRD;CLCA4;SLC38A4
37 extracellular ligand-gated ion channel activity (GO:0005230) 3/74 0.0380556 1.0000000 0 0 4.0540541 13.2515162 GRID1;GRIK1;GABRD
38 SH2 domain binding (GO:0042169) 2/31 0.0382674 1.0000000 0 0 6.4516129 21.0526212 DLC1;SKAP1
39 symporter activity (GO:0015293) 4/130 0.0416931 1.0000000 0 0 3.0769231 9.7766739 SLC5A7;SLC6A13;SLC4A10;SLC38A4
40 beta-tubulin binding (GO:0048487) 2/35 0.0477172 1.0000000 0 0 5.7142857 17.3855107 GJA1;SNCG
41 heme binding (GO:0020037) 4/137 0.0488995 1.0000000 0 0 2.9197080 8.8116443 CYP2W1;CYP2A13;CYP4F22;CYP2F1
42 RNA polymerase II activating transcription factor binding (GO:0001102) 2/36 0.0501995 1.0000000 0 0 5.5555556 16.6208344 BEX1;DUSP26
43 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines (GO:0016814) 2/36 0.0501995 1.0000000 0 0 5.5555556 16.6208344 APOBEC2;APOBEC3H
44 delayed rectifier potassium channel activity (GO:0005251) 2/36 0.0501995 1.0000000 0 0 5.5555556 16.6208344 KCNA3;KCNA4
45 carboxylic acid binding (GO:0031406) 5/200 0.0508440 1.0000000 0 0 2.5000000 7.4474830 FABP3;DDC;PLA2G1B;P4HA3;ANXA9
46 organic acid binding (GO:0043177) 5/201 0.0517369 1.0000000 0 0 2.4875622 7.3671242 FABP3;DDC;PLA2G1B;P4HA3;ANXA9
47 heparin binding (GO:0008201) 4/140 0.0521854 1.0000000 0 0 2.8571429 8.4370074 SMOC2;ECM2;FGF9;PCOLCE2
48 sulfur compound binding (GO:1901681) 5/206 0.0563388 1.0000000 0 0 2.4271845 6.9814843 SMOC2;ECM2;FGF9;PCOLCE2;GPC3
49 tetrapyrrole binding (GO:0046906) 4/146 0.0591100 1.0000000 0 0 2.7397260 7.7489166 CYP2W1;CYP2A13;CYP4F22;CYP2F1
50 inorganic cation transmembrane transporter activity (GO:0022890) 9/497 0.0627487 1.0000000 0 0 1.8108652 5.0135933 SLC5A7;GPM6A;KCNJ6;SLC6A13;KCNA3;CNGA1;KCNA4;KCNJ1;KCNK3
51 protein phosphatase binding (GO:0019903) 3/94 0.0682467 1.0000000 0 0 3.1914894 8.5679557 FCRL6;FLT4;SKAP1
52 axon guidance receptor activity (GO:0008046) 1/8 0.0772681 1.0000000 0 0 12.5000000 32.0059307 ROBO2
53 intracellular cAMP activated cation channel activity (GO:0005222) 1/8 0.0772681 1.0000000 0 0 12.5000000 32.0059307 CNGA1
54 heme transporter activity (GO:0015232) 1/8 0.0772681 1.0000000 0 0 12.5000000 32.0059307 ABCG2
55 carboxylic acid transmembrane transporter activity (GO:0046943) 3/101 0.0807525 1.0000000 0 0 2.9702970 7.4743550 SLC6A13;SLC7A14;SLC38A4
56 excitatory extracellular ligand-gated ion channel activity (GO:0005231) 2/48 0.0832284 1.0000000 0 0 4.1666667 10.3590263 GRID1;GRIK1
57 organic acid transmembrane transporter activity (GO:0005342) 3/104 0.0863951 1.0000000 0 0 2.8846154 7.0639147 SLC6A13;SLC7A14;SLC38A4
58 potassium ion binding (GO:0030955) 1/9 0.0864991 1.0000000 0 0 11.1111111 27.1957962 KCNA4
59 phospholipase activator activity (GO:0016004) 1/9 0.0864991 1.0000000 0 0 11.1111111 27.1957962 CCL5
60 calcium-dependent phospholipase A2 activity (GO:0047498) 1/9 0.0864991 1.0000000 0 0 11.1111111 27.1957962 PLA2G1B
61 fatty acid transporter activity (GO:0015245) 1/9 0.0864991 1.0000000 0 0 11.1111111 27.1957962 FABP3
62 peptidyl-proline 4-dioxygenase activity (GO:0031545) 1/9 0.0864991 1.0000000 0 0 11.1111111 27.1957962 P4HA3
63 protein-glutamine gamma-glutamyltransferase activity (GO:0003810) 1/9 0.0864991 1.0000000 0 0 11.1111111 27.1957962 TGM3
64 opioid receptor activity (GO:0004985) 1/9 0.0864991 1.0000000 0 0 11.1111111 27.1957962 NPBWR1
65 serine-type endopeptidase activity (GO:0004252) 4/167 0.0869547 1.0000000 0 0 2.3952096 5.8499844 TMPRSS11A;PRSS27;TMPRSS11E;TMPRSS11F
66 solute:sodium symporter activity (GO:0015370) 2/50 0.0892415 1.0000000 0 0 4.0000000 9.6656385 SLC5A7;SLC6A13
67 calcium ion binding (GO:0005509) 11/698 0.0922616 1.0000000 0 0 1.5759312 3.7556440 SMOC2;SCUBE1;PLA2G1B;PROS1;PADI3;SPARCL1;ANXA9;TGM3;LRP1B;CDH7;FBN1
68 tubulin binding (GO:0015631) 5/241 0.0948925 1.0000000 0 0 2.0746888 4.8859139 GJA1;DCX;SNCG;KIF12;JAKMIP2
69 sodium:amino acid symporter activity (GO:0005283) 1/10 0.0956382 1.0000000 0 0 10.0000000 23.4718325 SLC6A13
70 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor (GO:0016634) 1/10 0.0956382 1.0000000 0 0 10.0000000 23.4718325 ACOXL
71 low-density lipoprotein receptor activity (GO:0005041) 1/10 0.0956382 1.0000000 0 0 10.0000000 23.4718325 LRP1B
72 hydrolase activity, acting on ether bonds (GO:0016801) 1/10 0.0956382 1.0000000 0 0 10.0000000 23.4718325 ALOX12
73 activating transcription factor binding (GO:0033613) 2/53 0.0984918 1.0000000 0 0 3.7735849 8.7463472 BEX1;DUSP26
74 cyclic nucleotide-gated ion channel activity (GO:0043855) 1/11 0.1046863 1.0000000 0 0 9.0909091 20.5162457 CNGA1
75 receptor antagonist activity (GO:0048019) 1/11 0.1046863 1.0000000 0 0 9.0909091 20.5162457 CCL5
76 outward rectifier potassium channel activity (GO:0015271) 1/11 0.1046863 1.0000000 0 0 9.0909091 20.5162457 KCNA3
77 alcohol transmembrane transporter activity (GO:0015665) 1/11 0.1046863 1.0000000 0 0 9.0909091 20.5162457 SLC5A7
78 toxic substance binding (GO:0015643) 1/11 0.1046863 1.0000000 0 0 9.0909091 20.5162457 HLA-DQB2
79 lipase activator activity (GO:0060229) 1/11 0.1046863 1.0000000 0 0 9.0909091 20.5162457 CCL5
80 intracellular cyclic nucleotide activated cation channel activity (GO:0005221) 1/11 0.1046863 1.0000000 0 0 9.0909091 20.5162457 CNGA1
81 S100 protein binding (GO:0044548) 1/11 0.1046863 1.0000000 0 0 9.0909091 20.5162457 KCNK3
82 long-chain fatty acid binding (GO:0036041) 1/11 0.1046863 1.0000000 0 0 9.0909091 20.5162457 FABP3
83 p53 binding (GO:0002039) 2/56 0.1079976 1.0000000 0 0 3.5714286 7.9487379 ZNF385B;DUSP26
84 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines (GO:0016813) 1/12 0.1136443 1.0000000 0 0 8.3333333 18.1223455 PADI3
85 cation:amino acid symporter activity (GO:0005416) 1/12 0.1136443 1.0000000 0 0 8.3333333 18.1223455 SLC6A13
86 receptor inhibitor activity (GO:0030547) 1/12 0.1136443 1.0000000 0 0 8.3333333 18.1223455 CCL5
87 gap junction channel activity (GO:0005243) 1/12 0.1136443 1.0000000 0 0 8.3333333 18.1223455 GJA1
88 monocarboxylic acid binding (GO:0033293) 2/59 0.1177356 1.0000000 0 0 3.3898305 7.2519111 FABP3;PLA2G1B
89 serine-type peptidase activity (GO:0008236) 4/188 0.1200394 1.0000000 0 0 2.1276596 4.5105013 TMPRSS11A;PRSS27;TMPRSS11E;TMPRSS11F
90 G-protein coupled peptide receptor activity (GO:0008528) 3/121 0.1212860 1.0000000 0 0 2.4793388 5.2304234 MC4R;CX3CR1;NPBWR1
91 enzyme inhibitor activity (GO:0004857) 6/336 0.1216895 1.0000000 0 0 1.7857143 3.7612194 CAMK2N1;PROS1;SCGB1A1;GPC3;SCG5;A2ML1
92 MHC class I protein binding (GO:0042288) 1/13 0.1225132 1.0000000 0 0 7.6923077 16.1502800 CD8B
93 alkali metal ion binding (GO:0031420) 1/13 0.1225132 1.0000000 0 0 7.6923077 16.1502800 KCNA4
94 exodeoxyribonuclease activity, producing 5’-phosphomonoesters (GO:0016895) 1/13 0.1225132 1.0000000 0 0 7.6923077 16.1502800 MEIOB
95 phospholipase inhibitor activity (GO:0004859) 1/13 0.1225132 1.0000000 0 0 7.6923077 16.1502800 SCGB1A1
96 exodeoxyribonuclease activity (GO:0004529) 1/13 0.1225132 1.0000000 0 0 7.6923077 16.1502800 MEIOB
97 peptidyl-proline dioxygenase activity (GO:0031543) 1/13 0.1225132 1.0000000 0 0 7.6923077 16.1502800 P4HA3
98 inorganic anion exchanger activity (GO:0005452) 1/13 0.1225132 1.0000000 0 0 7.6923077 16.1502800 SLC4A10
99 glycosaminoglycan binding (GO:0005539) 4/190 0.1234406 1.0000000 0 0 2.1052632 4.4042012 SMOC2;ECM2;FGF9;PCOLCE2
100 secondary active transmembrane transporter activity (GO:0015291) 4/191 0.1251565 1.0000000 0 0 2.0942408 4.3522307 SLC5A7;SLC6A13;SLC4A10;SLC38A4
101 serine hydrolase activity (GO:0017171) 4/191 0.1251565 1.0000000 0 0 2.0942408 4.3522307 TMPRSS11A;PRSS27;TMPRSS11E;TMPRSS11F
102 peptide receptor activity (GO:0001653) 3/123 0.1256888 1.0000000 0 0 2.4390244 5.0584047 MC4R;CX3CR1;NPBWR1
103 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds (GO:0016810) 3/123 0.1256888 1.0000000 0 0 2.4390244 5.0584047 APOBEC2;APOBEC3H;PADI3
104 collagen binding (GO:0005518) 2/62 0.1276839 1.0000000 0 0 3.2258065 6.6393466 ECM2;PCOLCE2
105 lipoprotein particle receptor activity (GO:0030228) 1/14 0.1312938 1.0000000 0 0 7.1428571 14.5022708 LRP1B
106 protein tyrosine kinase activator activity (GO:0030296) 1/14 0.1312938 1.0000000 0 0 7.1428571 14.5022708 CCL5
107 acyl-CoA dehydrogenase activity (GO:0003995) 1/15 0.1399869 1.0000000 0 0 6.6666667 13.1080425 ACOXL
108 monosaccharide binding (GO:0048029) 2/66 0.1412394 1.0000000 0 0 3.0303030 5.9312088 P4HA3;CD207
109 organic anion transmembrane transporter activity (GO:0008514) 3/130 0.1415370 1.0000000 0 0 2.3076923 4.5119861 SLC6A13;SLC7A14;SLC38A4
110 oxidoreductase activity, acting on CH-OH group of donors (GO:0016614) 3/131 0.1438539 1.0000000 0 0 2.2900763 4.4403596 ADH1C;ADH1B;HHIP
111 carbohydrate binding (GO:0030246) 5/278 0.1469365 1.0000000 0 0 1.7985612 3.4491988 KLRK1;P4HA3;CD207;SFTPD;CLEC4F
112 Rac GTPase activator activity (GO:0030675) 1/16 0.1485935 1.0000000 0 0 6.2500000 11.9158813 DLC1
113 MHC protein complex binding (GO:0023023) 1/16 0.1485935 1.0000000 0 0 6.2500000 11.9158813 HLA-DOA
114 steroid hydroxylase activity (GO:0008395) 1/16 0.1485935 1.0000000 0 0 6.2500000 11.9158813 CH25H
115 MHC class II protein complex binding (GO:0023026) 1/16 0.1485935 1.0000000 0 0 6.2500000 11.9158813 HLA-DOA
116 quinone binding (GO:0048038) 1/16 0.1485935 1.0000000 0 0 6.2500000 11.9158813 HHIP
117 drug transmembrane transporter activity (GO:0015238) 1/16 0.1485935 1.0000000 0 0 6.2500000 11.9158813 ABCG2
118 photoreceptor activity (GO:0009881) 1/16 0.1485935 1.0000000 0 0 6.2500000 11.9158813 OPN1SW
119 phosphatase binding (GO:0019902) 3/136 0.1556231 1.0000000 0 0 2.2058824 4.1036430 FCRL6;FLT4;SKAP1
120 cGMP binding (GO:0030553) 1/17 0.1571144 1.0000000 0 0 5.8823529 10.8869493 CNGA1
121 heparan sulfate proteoglycan binding (GO:0043395) 1/17 0.1571144 1.0000000 0 0 5.8823529 10.8869493 GPC3
122 peptide hormone receptor binding (GO:0051428) 1/17 0.1571144 1.0000000 0 0 5.8823529 10.8869493 NPPC
123 CCR chemokine receptor binding (GO:0048020) 1/17 0.1571144 1.0000000 0 0 5.8823529 10.8869493 CCL5
124 peptidase regulator activity (GO:0061134) 4/209 0.1576916 1.0000000 0 0 1.9138756 3.5351465 PCOLCE2;PROS1;GPC3;A2ML1
125 chloride channel activity (GO:0005254) 2/72 0.1621027 1.0000000 0 0 2.7777778 5.0542366 GABRD;CLCA4
126 lipase inhibitor activity (GO:0055102) 1/18 0.1655504 1.0000000 0 0 5.5555556 9.9915545 SCGB1A1
127 acetylcholine receptor activity (GO:0015464) 1/18 0.1655504 1.0000000 0 0 5.5555556 9.9915545 ANXA9
128 lipopolysaccharide binding (GO:0001530) 1/18 0.1655504 1.0000000 0 0 5.5555556 9.9915545 BPI
129 mannose binding (GO:0005537) 1/18 0.1655504 1.0000000 0 0 5.5555556 9.9915545 CD207
130 neurotransmitter receptor activity (GO:0030594) 2/74 0.1691769 1.0000000 0 0 2.7027027 4.8021906 NPBWR1;ANXA9
131 GABA-A receptor activity (GO:0004890) 1/19 0.1739024 1.0000000 0 0 5.2631579 9.2066381 GABRD
132 neurotransmitter:sodium symporter activity (GO:0005328) 1/19 0.1739024 1.0000000 0 0 5.2631579 9.2066381 SLC6A13
133 cofactor transporter activity (GO:0051184) 1/19 0.1739024 1.0000000 0 0 5.2631579 9.2066381 ABCG2
134 drug transporter activity (GO:0090484) 1/20 0.1821712 1.0000000 0 0 5.0000000 8.5140422 ABCG2
135 sialyltransferase activity (GO:0008373) 1/20 0.1821712 1.0000000 0 0 5.0000000 8.5140422 ST6GAL2
136 L-ascorbic acid binding (GO:0031418) 1/21 0.1903576 1.0000000 0 0 4.7619048 7.8992886 P4HA3
137 anion channel activity (GO:0005253) 2/80 0.1906887 1.0000000 0 0 2.5000000 4.1427819 GABRD;CLCA4
138 active transmembrane transporter activity (GO:0022804) 5/307 0.1945656 1.0000000 0 0 1.6286645 2.6661005 SLC5A7;SLC6A13;SLC4A10;ABCG2;SLC38A4
139 solute:cation symporter activity (GO:0015294) 2/82 0.1979403 1.0000000 0 0 2.4390244 3.9507064 SLC5A7;SLC6A13
140 chemoattractant activity (GO:0042056) 1/22 0.1984626 1.0000000 0 0 4.5454545 7.3507034 CCL5
141 phosphatidylserine binding (GO:0001786) 1/23 0.2064868 1.0000000 0 0 4.3478261 6.8587782 ANXA9
142 wide pore channel activity (GO:0022829) 1/23 0.2064868 1.0000000 0 0 4.3478261 6.8587782 GJA1
143 cytokine receptor activity (GO:0004896) 2/85 0.2088786 1.0000000 0 0 2.3529412 3.6847110 CX3CR1;LEPR
144 chloride transmembrane transporter activity (GO:0015108) 2/86 0.2125388 1.0000000 0 0 2.3255814 3.6014667 GABRD;CLCA4
145 neurotransmitter transporter activity (GO:0005326) 1/24 0.2144310 1.0000000 0 0 4.1666667 6.4156966 SLC6A13
146 anion:anion antiporter activity (GO:0015301) 1/24 0.2144310 1.0000000 0 0 4.1666667 6.4156966 SLC4A10
147 adenylyltransferase activity (GO:0070566) 1/24 0.2144310 1.0000000 0 0 4.1666667 6.4156966 OASL
148 transferase activity, transferring amino-acyl groups (GO:0016755) 1/24 0.2144310 1.0000000 0 0 4.1666667 6.4156966 TGM3
149 intracellular ligand-gated ion channel activity (GO:0005217) 1/24 0.2144310 1.0000000 0 0 4.1666667 6.4156966 CNGA1
150 dioxygenase activity (GO:0051213) 2/87 0.2162053 1.0000000 0 0 2.2988506 3.5207517 P4HA3;ALOX12
151 phospholipase activity (GO:0004620) 2/90 0.2272373 1.0000000 0 0 2.2222222 3.2928009 PLA2G1B;CCL5
152 RNA polymerase II transcription factor binding (GO:0001085) 2/90 0.2272373 1.0000000 0 0 2.2222222 3.2928009 BEX1;DUSP26
153 G-protein coupled chemoattractant receptor activity (GO:0001637) 1/26 0.2300829 1.0000000 0 0 3.8461538 5.6512139 CX3CR1
154 chemokine receptor activity (GO:0004950) 1/26 0.2300829 1.0000000 0 0 3.8461538 5.6512139 CX3CR1
155 fatty acid binding (GO:0005504) 1/26 0.2300829 1.0000000 0 0 3.8461538 5.6512139 FABP3
156 neuropeptide receptor binding (GO:0071855) 1/26 0.2300829 1.0000000 0 0 3.8461538 5.6512139 KISS1
157 MHC protein binding (GO:0042287) 1/27 0.2377921 1.0000000 0 0 3.7037037 5.3198467 CD8B
158 thyroid hormone receptor binding (GO:0046966) 1/27 0.2377921 1.0000000 0 0 3.7037037 5.3198467 OASL
159 proteoglycan binding (GO:0043394) 1/27 0.2377921 1.0000000 0 0 3.7037037 5.3198467 GPC3
160 microtubule binding (GO:0008017) 3/171 0.2446846 1.0000000 0 0 1.7543860 2.4697984 DCX;KIF12;JAKMIP2
161 phosphatidylinositol phospholipase C activity (GO:0004435) 1/28 0.2454244 1.0000000 0 0 3.5714286 5.0170219 CCL5
162 organic acid:sodium symporter activity (GO:0005343) 1/28 0.2454244 1.0000000 0 0 3.5714286 5.0170219 SLC6A13
163 alpha-tubulin binding (GO:0043014) 1/28 0.2454244 1.0000000 0 0 3.5714286 5.0170219 SNCG
164 peptidase inhibitor activity (GO:0030414) 3/173 0.2500255 1.0000000 0 0 1.7341040 2.4038017 PROS1;GPC3;A2ML1
165 phospholipase A2 activity (GO:0004623) 1/29 0.2529808 1.0000000 0 0 3.4482759 4.7394545 PLA2G1B
166 phospholipase C activity (GO:0004629) 1/30 0.2604618 1.0000000 0 0 3.3333333 4.4843302 CCL5
167 monocarboxylic acid transmembrane transporter activity (GO:0008028) 1/30 0.2604618 1.0000000 0 0 3.3333333 4.4843302 SLC6A13
168 quaternary ammonium group binding (GO:0050997) 1/31 0.2678683 1.0000000 0 0 3.2258065 4.2492255 SLC5A7
169 insulin receptor binding (GO:0005158) 1/32 0.2752010 1.0000000 0 0 3.1250000 4.0320428 DOK5
170 organic hydroxy compound transmembrane transporter activity (GO:1901618) 1/32 0.2752010 1.0000000 0 0 3.1250000 4.0320428 SLC5A7
171 peptide hormone binding (GO:0017046) 1/33 0.2824605 1.0000000 0 0 3.0303030 3.8309588 MC4R
172 lipase activity (GO:0016298) 2/105 0.2827547 1.0000000 0 0 1.9047619 2.4060489 PLA2G1B;CCL5
173 amino acid binding (GO:0016597) 2/107 0.2901569 1.0000000 0 0 1.8691589 2.3127732 DDC;ANXA9
174 peptide antigen binding (GO:0042605) 1/35 0.2967634 1.0000000 0 0 2.8571429 3.4709146 HLA-DQB2
175 scaffold protein binding (GO:0097110) 1/35 0.2967634 1.0000000 0 0 2.8571429 3.4709146 GJA1
176 carboxy-lyase activity (GO:0016831) 1/36 0.3038081 1.0000000 0 0 2.7777778 3.3093308 DDC
177 cyclic nucleotide binding (GO:0030551) 1/36 0.3038081 1.0000000 0 0 2.7777778 3.3093308 CNGA1
178 calcium-dependent phospholipid binding (GO:0005544) 1/36 0.3038081 1.0000000 0 0 2.7777778 3.3093308 ANXA9
179 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5’-phosphomonoesters (GO:0016796) 1/37 0.3107825 1.0000000 0 0 2.7027027 3.1585455 MEIOB
180 peptidase activator activity (GO:0016504) 1/37 0.3107825 1.0000000 0 0 2.7027027 3.1585455 PCOLCE2
181 oxygen binding (GO:0019825) 1/37 0.3107825 1.0000000 0 0 2.7027027 3.1585455 CYP2F1
182 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor (GO:0016616) 2/115 0.3196498 1.0000000 0 0 1.7391304 1.9835291 ADH1C;ADH1B
183 Rho GTPase activator activity (GO:0005100) 1/39 0.3245236 1.0000000 0 0 2.5641026 2.8856335 DLC1
184 protein homodimerization activity (GO:0042803) 8/653 0.3300879 1.0000000 0 0 1.2251149 1.3579128 NPPC;DMRT1;CCL5;QPRT;ANXA9;KCNK3;RUNX1T1;ABCG2
185 protein self-association (GO:0043621) 1/40 0.3312915 1.0000000 0 0 2.5000000 2.7618913 CCL5
186 inorganic anion transmembrane transporter activity (GO:0015103) 2/119 0.3342935 1.0000000 0 0 1.6806723 1.8415730 GABRD;CLCA4
187 SH3 domain binding (GO:0017124) 2/119 0.3342935 1.0000000 0 0 1.6806723 1.8415730 GJA1;SKAP1
188 phosphatidylinositol-4,5-bisphosphate binding (GO:0005546) 1/41 0.3379920 1.0000000 0 0 2.4390244 2.6456903 KCNJ1
189 growth factor receptor binding (GO:0070851) 2/121 0.3415820 1.0000000 0 0 1.6528926 1.7754835 FGF9;FGF18
190 protein kinase regulator activity (GO:0019887) 2/121 0.3415820 1.0000000 0 0 1.6528926 1.7754835 CAMK2N1;CCL5
191 receptor regulator activity (GO:0030545) 1/42 0.3446257 1.0000000 0 0 2.3809524 2.5364201 CCL5
192 neuropeptide receptor activity (GO:0008188) 1/43 0.3511932 1.0000000 0 0 2.3255814 2.4335320 NPBWR1
193 antigen binding (GO:0003823) 3/212 0.3560832 1.0000000 0 0 1.4150943 1.4612135 IGHG4;HLA-DOA;HLA-DQB2
194 cytokine activity (GO:0005125) 3/213 0.3588085 1.0000000 0 0 1.4084507 1.4436149 CCL5;SCGB3A1;SLURP1
195 3’-5’ exonuclease activity (GO:0008408) 1/45 0.3641324 1.0000000 0 0 2.2222222 2.2449725 MEIOB
196 sodium ion transmembrane transporter activity (GO:0015081) 2/128 0.3668834 1.0000000 0 0 1.5625000 1.5667361 SLC5A7;SLC6A13
197 protein tyrosine/serine/threonine phosphatase activity (GO:0008138) 1/46 0.3705054 1.0000000 0 0 2.1739130 2.1584503 DUSP26
198 chemokine activity (GO:0008009) 1/47 0.3768149 1.0000000 0 0 2.1276596 2.0765984 CCL5
199 anion:cation symporter activity (GO:0015296) 1/48 0.3830614 1.0000000 0 0 2.0833333 1.9990833 SLC6A13
200 protein heterodimerization activity (GO:0046982) 5/408 0.3869998 1.0000000 0 0 1.2254902 1.1633960 ROBO2;SCUBE1;DMRT1;JAM2;KCNK3
201 protein kinase activator activity (GO:0030295) 1/49 0.3892456 1.0000000 0 0 2.0408163 1.9256015 CCL5
202 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors (GO:0016706) 1/49 0.3892456 1.0000000 0 0 2.0408163 1.9256015 P4HA3
203 SH3/SH2 adaptor activity (GO:0005070) 1/50 0.3953682 1.0000000 0 0 2.0000000 1.8558758 SKAP1
204 carbon-carbon lyase activity (GO:0016830) 1/51 0.4014296 1.0000000 0 0 1.9607843 1.7896531 DDC
205 kinase regulator activity (GO:0019207) 2/141 0.4128121 1.0000000 0 0 1.4184397 1.2549827 CAMK2N1;CCL5
206 double-stranded RNA binding (GO:0003725) 1/53 0.4133717 1.0000000 0 0 1.8867925 1.6668075 OASL
207 transferase activity, transferring pentosyl groups (GO:0016763) 1/53 0.4133717 1.0000000 0 0 1.8867925 1.6668075 QPRT
208 modified amino acid binding (GO:0072341) 1/53 0.4133717 1.0000000 0 0 1.8867925 1.6668075 ANXA9
209 protein kinase inhibitor activity (GO:0004860) 1/54 0.4192536 1.0000000 0 0 1.8518519 1.6097765 CAMK2N1
210 kinase activator activity (GO:0019209) 1/55 0.4250768 1.0000000 0 0 1.8181818 1.5554281 CCL5
211 repressing transcription factor binding (GO:0070491) 1/55 0.4250768 1.0000000 0 0 1.8181818 1.5554281 HLA-DQB2
212 phosphatidylinositol bisphosphate binding (GO:1902936) 1/56 0.4308418 1.0000000 0 0 1.7857143 1.5035968 KCNJ1
213 oxidoreductase activity, acting on the CH-CH group of donors (GO:0016627) 1/56 0.4308418 1.0000000 0 0 1.7857143 1.5035968 ACOXL
214 steroid hormone receptor activity (GO:0003707) 1/57 0.4365494 1.0000000 0 0 1.7543860 1.4541294 OR51E2
215 pyridoxal phosphate binding (GO:0030170) 1/57 0.4365494 1.0000000 0 0 1.7543860 1.4541294 DDC
216 chemokine receptor binding (GO:0042379) 1/57 0.4365494 1.0000000 0 0 1.7543860 1.4541294 CCL5
217 kinase inhibitor activity (GO:0019210) 1/57 0.4365494 1.0000000 0 0 1.7543860 1.4541294 CAMK2N1
218 deoxyribonuclease activity (GO:0004536) 1/57 0.4365494 1.0000000 0 0 1.7543860 1.4541294 MEIOB
219 antiporter activity (GO:0015297) 1/62 0.4642441 1.0000000 0 0 1.6129032 1.2376529 SLC4A10
220 cargo receptor activity (GO:0038024) 1/62 0.4642441 1.0000000 0 0 1.6129032 1.2376529 LRP1B
221 hormone binding (GO:0042562) 1/62 0.4642441 1.0000000 0 0 1.6129032 1.2376529 MC4R
222 hormone receptor binding (GO:0051427) 2/160 0.4768118 1.0000000 0 0 1.2500000 0.9257918 NPPC;OASL
223 transmembrane receptor protein tyrosine kinase activity (GO:0004714) 1/65 0.4802063 1.0000000 0 0 1.5384615 1.1285222 FLT4
224 growth factor activity (GO:0008083) 2/163 0.4865301 1.0000000 0 0 1.2269939 0.8839957 FGF9;FGF18
225 signaling adaptor activity (GO:0035591) 1/67 0.4905840 1.0000000 0 0 1.4925373 1.0629235 SKAP1
226 extracellular matrix structural constituent (GO:0005201) 1/68 0.4956953 1.0000000 0 0 1.4705882 1.0320498 FBN1
227 endopeptidase inhibitor activity (GO:0004866) 2/166 0.4961360 1.0000000 0 0 1.2048193 0.8444640 PROS1;A2ML1
228 endopeptidase regulator activity (GO:0061135) 2/171 0.5118910 1.0000000 0 0 1.1695906 0.7832088 PROS1;A2ML1
229 peptide binding (GO:0042277) 2/172 0.5150033 1.0000000 0 0 1.1627907 0.7716070 MC4R;HLA-DQB2
230 core promoter proximal region sequence-specific DNA binding (GO:0000987) 2/176 0.5273210 1.0000000 0 0 1.1363636 0.7272111 DMRT1;FEZF2
231 exonuclease activity (GO:0004527) 1/75 0.5300734 1.0000000 0 0 1.3333333 0.8463198 MEIOB
232 amide binding (GO:0033218) 2/177 0.5303674 1.0000000 0 0 1.1299435 0.7165935 MC4R;HLA-DQB2
233 core promoter proximal region DNA binding (GO:0001159) 2/178 0.5334006 1.0000000 0 0 1.1235955 0.7061602 DMRT1;FEZF2
234 single-stranded DNA binding (GO:0003697) 1/76 0.5347903 1.0000000 0 0 1.3157895 0.8235271 MEIOB
235 microtubule motor activity (GO:0003777) 1/78 0.5440833 1.0000000 0 0 1.2820513 0.7803242 KIF12
236 small conjugating protein ligase binding (GO:0044389) 2/182 0.5453994 1.0000000 0 0 1.0989011 0.6661944 MC4R;HLA-DQB2
237 ubiquitin protein ligase binding (GO:0031625) 2/182 0.5453994 1.0000000 0 0 1.0989011 0.6661944 MC4R;HLA-DQB2
238 vitamin binding (GO:0019842) 1/80 0.5531916 1.0000000 0 0 1.2500000 0.7400636 P4HA3
239 protein transporter activity (GO:0008565) 1/81 0.5576776 1.0000000 0 0 1.2345679 0.7209558 RAMP2
240 acid-amino acid ligase activity (GO:0016881) 1/81 0.5576776 1.0000000 0 0 1.2345679 0.7209558 UBE2QL1
241 glycoprotein binding (GO:0001948) 1/81 0.5576776 1.0000000 0 0 1.2345679 0.7209558 GPC3
242 transmembrane receptor protein kinase activity (GO:0019199) 1/82 0.5621188 1.0000000 0 0 1.2195122 0.7024903 FLT4
243 steroid binding (GO:0005496) 1/82 0.5621188 1.0000000 0 0 1.2195122 0.7024903 PLA2G1B
244 lipid transporter activity (GO:0005319) 1/87 0.5836680 1.0000000 0 0 1.1494253 0.6188770 FABP3
245 endopeptidase activity (GO:0004175) 4/411 0.5909584 1.0000000 0 0 0.9732360 0.5119315 TMPRSS11A;PRSS27;TMPRSS11E;TMPRSS11F
246 alcohol binding (GO:0043178) 1/89 0.5919892 1.0000000 0 0 1.1235955 0.5890639 SLC5A7
247 phosphoric diester hydrolase activity (GO:0008081) 1/90 0.5960875 1.0000000 0 0 1.1111111 0.5748531 CCL5
248 phosphatidylinositol phosphate binding (GO:1901981) 1/91 0.6001449 1.0000000 0 0 1.0989011 0.5610815 KCNJ1
249 PDZ domain binding (GO:0030165) 1/96 0.6198314 1.0000000 0 0 1.0416667 0.4982372 GJA1
250 serine-type endopeptidase inhibitor activity (GO:0004867) 1/98 0.6274332 1.0000000 0 0 1.0204082 0.4756306 A2ML1
251 unfolded protein binding (GO:0051082) 1/101 0.6385533 1.0000000 0 0 0.9900990 0.4441090 SCG5
252 integrin binding (GO:0005178) 1/102 0.6421861 1.0000000 0 0 0.9803922 0.4341933 ECM2
253 protein tyrosine phosphatase activity (GO:0004725) 1/103 0.6457826 1.0000000 0 0 0.9708738 0.4245557 DUSP26
254 ATPase activity, coupled to transmembrane movement of substances (GO:0042626) 1/104 0.6493431 1.0000000 0 0 0.9615385 0.4151866 ABCG2
255 ATPase activity, coupled to movement of substances (GO:0043492) 1/105 0.6528680 1.0000000 0 0 0.9523810 0.4060766 ABCG2
256 calcium channel activity (GO:0005262) 1/108 0.6632325 1.0000000 0 0 0.9259259 0.3802127 GPM6A
257 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances (GO:0016820) 1/108 0.6632325 1.0000000 0 0 0.9259259 0.3802127 ABCG2
258 double-stranded DNA binding (GO:0003690) 1/109 0.6666184 1.0000000 0 0 0.9174312 0.3720527 HLF
259 G-protein coupled receptor binding (GO:0001664) 2/229 0.6700506 1.0000000 0 0 0.8733624 0.3496962 KISS1;CCL5
260 primary active transmembrane transporter activity (GO:0015399) 1/111 0.6732890 1.0000000 0 0 0.9009009 0.3563789 ABCG2
261 P-P-bond-hydrolysis-driven transmembrane transporter activity (GO:0015405) 1/111 0.6732890 1.0000000 0 0 0.9009009 0.3563789 ABCG2
262 carboxylic ester hydrolase activity (GO:0052689) 1/111 0.6732890 1.0000000 0 0 0.9009009 0.3563789 PLA2G1B
263 transcription factor binding (GO:0008134) 4/464 0.6851836 1.0000000 0 0 0.8620690 0.3259211 BEX1;DUSP26;HLA-DQB2;OASL
264 ligase activity, forming carbon-nitrogen bonds (GO:0016879) 1/117 0.6925144 1.0000000 0 0 0.8547009 0.3140395 UBE2QL1
265 structure-specific DNA binding (GO:0043566) 2/241 0.6971041 1.0000000 0 0 0.8298755 0.2994361 HLF;MEIOB
266 hormone activity (GO:0005179) 1/122 0.7076726 1.0000000 0 0 0.8196721 0.2834211 NPPC
267 growth factor binding (GO:0019838) 1/123 0.7106138 1.0000000 0 0 0.8130081 0.2777449 FLT4
268 receptor signaling protein activity (GO:0005057) 1/124 0.7135255 1.0000000 0 0 0.8064516 0.2722073 DOK5
269 Ras GTPase activator activity (GO:0005099) 1/124 0.7135255 1.0000000 0 0 0.8064516 0.2722073 DLC1
270 kinase binding (GO:0019900) 4/487 0.7210317 1.0000000 0 0 0.8213552 0.2686424 CAMK2N1;DCX;SKAP1;JAKMIP2
271 calcium ion transmembrane transporter activity (GO:0015085) 1/127 0.7220870 1.0000000 0 0 0.7874016 0.2563855 GPM6A
272 motor activity (GO:0003774) 1/132 0.7357941 1.0000000 0 0 0.7575758 0.2324280 KIF12
273 protein binding, bridging (GO:0030674) 1/134 0.7410867 1.0000000 0 0 0.7462687 0.2236102 SKAP1
274 cofactor binding (GO:0048037) 2/266 0.7475973 1.0000000 0 0 0.7518797 0.2187149 DDC;HHIP
275 nuclear hormone receptor binding (GO:0035257) 1/139 0.7538610 1.0000000 0 0 0.7194245 0.2032714 OASL
276 nucleotidyltransferase activity (GO:0016779) 1/140 0.7563396 1.0000000 0 0 0.7142857 0.1994748 OASL
277 protein tyrosine kinase activity (GO:0004713) 1/142 0.7612226 1.0000000 0 0 0.7042254 0.1921334 FLT4
278 binding, bridging (GO:0060090) 1/146 0.7706983 1.0000000 0 0 0.6849315 0.1783961 SKAP1
279 transferase activity, transferring glycosyl groups (GO:0016757) 2/280 0.7726084 1.0000000 0 0 0.7142857 0.1842735 ST6GAL2;QPRT
280 guanyl ribonucleotide binding (GO:0032561) 3/405 0.7735836 1.0000000 0 0 0.7407407 0.1901641 DIRAS2;SCG5;CNGA1
281 guanyl nucleotide binding (GO:0019001) 3/406 0.7750152 1.0000000 0 0 0.7389163 0.1883295 DIRAS2;SCG5;CNGA1
282 divalent inorganic cation transmembrane transporter activity (GO:0072509) 1/154 0.7885417 1.0000000 0 0 0.6493506 0.1542663 GPM6A
283 phospholipid binding (GO:0005543) 2/296 0.7985326 1.0000000 0 0 0.6756757 0.1520132 ANXA9;KCNJ1
284 isomerase activity (GO:0016853) 1/159 0.7989850 1.0000000 0 0 0.6289308 0.1411403 ALOX12
285 protein C-terminus binding (GO:0008022) 1/162 0.8050029 1.0000000 0 0 0.6172840 0.1338947 KCNK3
286 RNA polymerase II core promoter proximal region sequence-specific DNA binding (GO:0000978) 1/167 0.8146371 1.0000000 0 0 0.5988024 0.1227620 FEZF2
287 protein kinase binding (GO:0019901) 3/437 0.8158405 1.0000000 0 0 0.6864989 0.1397275 CAMK2N1;DCX;SKAP1
288 cell adhesion molecule binding (GO:0050839) 1/168 0.8165063 1.0000000 0 0 0.5952381 0.1206671 ECM2
289 phosphoprotein phosphatase activity (GO:0004721) 1/172 0.8237975 1.0000000 0 0 0.5813953 0.1126922 DUSP26
290 cysteine-type peptidase activity (GO:0008234) 1/172 0.8237975 1.0000000 0 0 0.5813953 0.1126922 CTSW
291 enzyme activator activity (GO:0008047) 3/446 0.8264580 1.0000000 0 0 0.6726457 0.1282104 PCOLCE2;DLC1;CCL5
292 lyase activity (GO:0016829) 1/177 0.8325073 1.0000000 0 0 0.5649718 0.1035668 DDC
293 phosphatidylinositol binding (GO:0035091) 1/178 0.8341972 1.0000000 0 0 0.5617978 0.1018458 KCNJ1
294 metallopeptidase activity (GO:0008237) 1/188 0.8501902 1.0000000 0 0 0.5319149 0.0863272 ADAMTSL1
295 transcription regulatory region sequence-specific DNA binding (GO:0000976) 2/340 0.8568359 1.0000000 0 0 0.5882353 0.0908876 DMRT1;FEZF2
296 nuclease activity (GO:0004518) 1/195 0.8604625 1.0000000 0 0 0.5128205 0.0770693 MEIOB
297 small GTPase regulator activity (GO:0005083) 1/195 0.8604625 1.0000000 0 0 0.5128205 0.0770693 DLC1
298 phosphoric ester hydrolase activity (GO:0042578) 2/360 0.8778898 1.0000000 0 0 0.5555556 0.0723523 CCL5;DUSP26
299 GTP binding (GO:0005525) 2/385 0.9002020 1.0000000 0 0 0.5194805 0.0546161 DIRAS2;SCG5
300 cytokine receptor binding (GO:0005126) 1/228 0.9002045 1.0000000 0 0 0.4385965 0.0461111 CCL5
301 ATPase activity (GO:0016887) 2/395 0.9080188 1.0000000 0 0 0.5063291 0.0488558 KIF12;ABCG2
302 transferase activity, transferring acyl groups (GO:0016746) 1/243 0.9143243 1.0000000 0 0 0.4115226 0.0368601 TGM3
303 chromatin binding (GO:0003682) 2/420 0.9251344 1.0000000 0 0 0.4761905 0.0370554 DMRT1;MEIOB
304 GTPase activator activity (GO:0005096) 1/265 0.9315150 1.0000000 0 0 0.3773585 0.0267709 DLC1
305 phosphatase activity (GO:0016791) 1/266 0.9322090 1.0000000 0 0 0.3759398 0.0263903 DUSP26
306 ATPase activity, coupled (GO:0042623) 1/272 0.9362286 1.0000000 0 0 0.3676471 0.0242263 ABCG2
307 zinc ion binding (GO:0008270) 8/1256 0.9391936 1.0000000 0 0 0.6369427 0.0399577 ADAMTSL1;APOBEC2;ADH1C;APOBEC3H;ADH1B;HHIP;PEG10;ZNF385B
308 RNA polymerase II regulatory region sequence-specific DNA binding (GO:0000977) 1/284 0.9435701 1.0000000 0 0 0.3521127 0.0204523 FEZF2
309 RNA polymerase II regulatory region DNA binding (GO:0001012) 1/288 0.9458253 1.0000000 0 0 0.3472222 0.0193394 FEZF2
310 GTPase regulator activity (GO:0030695) 1/310 0.9567174 1.0000000 0 0 0.3225806 0.0142733 DLC1
311 nucleoside-triphosphatase regulator activity (GO:0060589) 1/330 0.9647144 1.0000000 0 0 0.3030303 0.0108858 DLC1
312 olfactory receptor activity (GO:0004984) 1/420 0.9859630 1.0000000 0 0 0.2380952 0.0033658 OR51E2
313 ligase activity (GO:0016874) 1/431 0.9874621 1.0000000 0 0 0.2320186 0.0029274 UBE2QL1
314 ATP binding (GO:0005524) 6/1494 0.9978601 1.0000000 0 0 0.4016064 0.0008603 FLT4;UBE2QL1;KIF12;KCNJ1;ABCG2;OASL

Reproducibility

For reproducibility:

## datetime

Sys.time()
## [1] "2020-12-08 14:37:05 EST"
## session info

sessionInfo()
## R version 4.0.2 (2020-06-22)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: CentOS Linux 7 (Core)
## 
## Matrix products: default
## BLAS:   /share/pkg.7/r/4.0.2/install/lib/libopenblasp-r0.3.7.so
## LAPACK: /share/pkg.7/r/4.0.2/install/lib/liblapack.so.3.9.0
## 
## locale:
## [1] C
## 
## attached base packages:
## [1] parallel  stats4    stats     graphics  grDevices utils     datasets 
## [8] methods   base     
## 
## other attached packages:
##  [1] limma_3.46.0                affy_1.68.0                
##  [3] biomaRt_2.46.0              enrichR_2.1                
##  [5] kableExtra_1.3.1            knitr_1.30                 
##  [7] DESeq2_1.30.0               RColorBrewer_1.1-2         
##  [9] pheatmap_1.0.12             ggplot2_3.3.2              
## [11] dplyr_1.0.2                 readxl_1.3.1               
## [13] SummarizedExperiment_1.20.0 Biobase_2.50.0             
## [15] GenomicRanges_1.42.0        GenomeInfoDb_1.26.0        
## [17] IRanges_2.24.0              S4Vectors_0.28.0           
## [19] BiocGenerics_0.36.0         MatrixGenerics_1.2.0       
## [21] matrixStats_0.57.0          plyr_1.8.6                 
## [23] rmarkdown_2.5              
## 
## loaded via a namespace (and not attached):
##  [1] bitops_1.0-6           bit64_4.0.5            webshot_0.5.2         
##  [4] progress_1.2.2         httr_1.4.2             tools_4.0.2           
##  [7] R6_2.5.0               affyio_1.60.0          DBI_1.1.0             
## [10] colorspace_2.0-0       withr_2.3.0            tidyselect_1.1.0      
## [13] prettyunits_1.1.1      bit_4.0.4              curl_4.3              
## [16] compiler_4.0.2         preprocessCore_1.52.0  rvest_0.3.6           
## [19] xml2_1.3.2             DelayedArray_0.16.0    labeling_0.4.2        
## [22] scales_1.1.1           genefilter_1.72.0      askpass_1.1           
## [25] rappdirs_0.3.1         stringr_1.4.0          digest_0.6.27         
## [28] XVector_0.30.0         pkgconfig_2.0.3        htmltools_0.5.0       
## [31] dbplyr_2.0.0           highr_0.8              rlang_0.4.8           
## [34] rstudioapi_0.13        RSQLite_2.2.1          farver_2.0.3          
## [37] generics_0.1.0         BiocParallel_1.24.1    RCurl_1.98-1.2        
## [40] magrittr_2.0.1         GenomeInfoDbData_1.2.4 Matrix_1.2-18         
## [43] Rcpp_1.0.5             munsell_0.5.0          lifecycle_0.2.0       
## [46] stringi_1.5.3          yaml_2.2.1             zlibbioc_1.36.0       
## [49] BiocFileCache_1.14.0   grid_4.0.2             blob_1.2.1            
## [52] crayon_1.3.4           lattice_0.20-41        splines_4.0.2         
## [55] annotate_1.68.0        hms_0.5.3              locfit_1.5-9.4        
## [58] pillar_1.4.6           rjson_0.2.20           geneplotter_1.68.0    
## [61] XML_3.99-0.5           glue_1.4.2             evaluate_0.14         
## [64] BiocManager_1.30.10    vctrs_0.3.5            cellranger_1.1.0      
## [67] gtable_0.3.0           openssl_1.4.3          purrr_0.3.4           
## [70] assertthat_0.2.1       xfun_0.19              xtable_1.8-4          
## [73] survival_3.1-12        viridisLite_0.3.0      tibble_3.0.4          
## [76] AnnotationDbi_1.52.0   memoise_1.1.0          ellipsis_0.3.1